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<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGZ5</accession>
    <name>F0LGZ5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">tRNA (cytidine(56)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="6 10">2.1.1.206</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">tRNA ribose 2'-O-methyltransferase aTrm56</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_01227</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42968"/>
            <dbReference type="Rhea" id="RHEA-COMP:10308"/>
            <dbReference type="Rhea" id="RHEA-COMP:10309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.206"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the aTrm56 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.206" evidence="6 10"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01227"/>
    <dbReference type="EnsemblBacteria" id="ADT84203">
        <property type="protein sequence ID" value="ADT84203"/>
        <property type="gene ID" value="TERMP_01227"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01227"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1228"/>
    <dbReference type="eggNOG" id="arCOG01857">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123709_0_0_2"/>
    <dbReference type="OMA" id="VVHLTMY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00077">
        <property type="entry name" value="tRNA_methyltr_aTrm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002845">
        <property type="entry name" value="tRNA_mtfrase_aTrm56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42197">
        <property type="entry name" value="PTHR42197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01994">
        <property type="entry name" value="Trm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016123">
        <property type="entry name" value="UCP016123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="10">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="10">
        <location>
            <begin position="121"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT84203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="173" mass="19775" checksum="16E1A890F44A9CBF" modified="2011-05-03" version="1">MGHRPERDKRITTHVALTARAFGADGIIIAADEDEHVRESVEDVIKRWGGPFFIKFDPHWKRIMREWKGKIVHLTMYGIHVDDALPKIREHLRHGENILVVVGAEKVPREVYELAHYNVAIGNQPHSEVAALAVFLDRLLEGEGLRKEFENAKLKIIPQERGKKVIEVGKNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH16</accession>
    <name>F0LH16_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01248"/>
    <dbReference type="EnsemblBacteria" id="ADT84224">
        <property type="protein sequence ID" value="ADT84224"/>
        <property type="gene ID" value="TERMP_01248"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01248"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1250"/>
    <dbReference type="eggNOG" id="arCOG01791">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2748392_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="70" mass="7974" checksum="D7A8CBAE62746C8A" modified="2011-05-03" version="1">MGHEVVGVDIMDGFLEIALDFKNKFDIVLLLFTSFGYFSDEENFRVLKNVYAALKPSGHFVLDVPNTEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH18</accession>
    <name>F0LH18_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UbiE/COQ5 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467524.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01250"/>
    <dbReference type="EnsemblBacteria" id="ADT84226">
        <property type="protein sequence ID" value="ADT84226"/>
        <property type="gene ID" value="TERMP_01250"/>
    </dbReference>
    <dbReference type="GeneID" id="10041567"/>
    <dbReference type="KEGG" id="tba:TERMP_01250"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1252"/>
    <dbReference type="eggNOG" id="arCOG01790">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102060_0_0_2"/>
    <dbReference type="OMA" id="WIVIQES"/>
    <dbReference type="OrthoDB" id="49237at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="50"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="237" mass="27148" checksum="54AFF6F97C4F0920" modified="2011-05-03" version="1">MFRDLGETFEPTYKEKLWMYDPRSEAGKRRMEKQKALLGKFLPIKSGKALDIGCGMGISTFALEELGFEVTGIDVQEELVEKAKEIAGDIGYKAKFMVMDARKLDFPNESFDLVALLGNPLPHLSVYDFDRIVQEAFRVLKPGGALFIEYADWVKLLHDGYKHVLVEDPFISFHVSLDTTKGQVERLFINLEKGYFFRVKINVWAPWIVEFILRKAGFDVKSHYTSERIVVTIGVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH21</accession>
    <name>F0LH21_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01253"/>
    <dbReference type="EnsemblBacteria" id="ADT84229">
        <property type="protein sequence ID" value="ADT84229"/>
        <property type="gene ID" value="TERMP_01253"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01253"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1255"/>
    <dbReference type="eggNOG" id="arCOG00132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796010_0_0_2"/>
    <dbReference type="OMA" id="IDSFAWR"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="348" mass="38473" checksum="6C01F086BBEE0AA0" modified="2011-05-03" version="1">MYIQYFLLDLGLAKAKIGLVFSLALLMRAFGNIIGGKIADLLGYKRTLLVGYTIYAFPPLLFLLHNALFASLVYPIMSLGSGIGTPAKSLFIVEQTQRRKGLTYMLVQRVLPSIPPALTAPVGAKLYEMGKYYVAVFMGFFGLLISLLLLVFLKDTKRERAQNPFDFNLLRSKSFTDLLFLYSLDAFSTEAVQWIVPLYLRELGYSVLDYGFLISAQTLIIAFGGTFAGIFVDRFEPVNALGLSYLVVAMSLLAFSLGKGWILALAYLLWKTFGMIGFAALPLLIERYFSDIKASAFGTINAMTTLISIPAPSFGGVLLRFGVGVPFIFKAATNFVCFIWVKISLNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH49</accession>
    <name>F0LH49_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporte protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466309.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00033"/>
    <dbReference type="EnsemblBacteria" id="ADT83011">
        <property type="protein sequence ID" value="ADT83011"/>
        <property type="gene ID" value="TERMP_00033"/>
    </dbReference>
    <dbReference type="GeneID" id="26137885"/>
    <dbReference type="KEGG" id="tba:TERMP_00033"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.32"/>
    <dbReference type="eggNOG" id="arCOG03159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2550470_0_0_2"/>
    <dbReference type="OMA" id="ATMEKVH"/>
    <dbReference type="OrthoDB" id="121906at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="82" mass="8840" checksum="BFB5DB54D646DA01" modified="2011-05-03" version="1">MRTVIKGLIIIIILLAIALPFASNNPDGLEATMEKVGLEEHPVYEAPLDYGETWGQSIVMGLIGIILVFGVSYGLAKLIKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHF6</accession>
    <name>F0LHF6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467581.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01308"/>
    <dbReference type="EnsemblBacteria" id="ADT84283">
        <property type="protein sequence ID" value="ADT84283"/>
        <property type="gene ID" value="TERMP_01308"/>
    </dbReference>
    <dbReference type="GeneID" id="26136787"/>
    <dbReference type="KEGG" id="tba:TERMP_01308"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1309"/>
    <dbReference type="eggNOG" id="arCOG01285">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119412_2_2_2"/>
    <dbReference type="OMA" id="IYYGTKF"/>
    <dbReference type="OrthoDB" id="120594at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="135" mass="15801" checksum="4D96D657970DF589" modified="2011-05-03" version="1">MGKPMQVSRFWRHFKEKYRLVGSKCKKCGKIHFPPRQVCDECGSREMEEIQLSGRGKVISWTIVRNPPSGFEYYKPYPLALIELEEGPIILAQLTDVDPEEITFGMEVEMVTRKIREFNEDGIILYGYKFRPPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHG4</accession>
    <name>F0LHG4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetate--CoA ligase (ADP-forming)</fullName>
            <ecNumber evidence="2">6.2.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15081"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.2.1.13" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467589.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01316"/>
    <dbReference type="EnsemblBacteria" id="ADT84291">
        <property type="protein sequence ID" value="ADT84291"/>
        <property type="gene ID" value="TERMP_01316"/>
    </dbReference>
    <dbReference type="GeneID" id="26136797"/>
    <dbReference type="KEGG" id="tba:TERMP_01316"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1317"/>
    <dbReference type="eggNOG" id="arCOG01340">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007415_2_3_2"/>
    <dbReference type="OMA" id="ICVVPTF"/>
    <dbReference type="OrthoDB" id="15044at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014089">
        <property type="entry name" value="AcCoA-synth-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02717">
        <property type="entry name" value="AcCoA-syn-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="454" mass="49546" checksum="92AD9D0D8997E7A6" modified="2011-05-03" version="1">MTFDYFFKPKAIAVIGASNDPLKLGYEVFKNLKKYKEGRVYPVNVKDEVVQGVKAYKNVRNIPDEVDLAVIVVPKRFVKQTVIDCGEKGVKGIVLITAGFGETGEEGKREEKELVEIAHKYGMRIIGPNCVGIMNTHNDMNATFIMDAKRGDIAFVSQSGALGAGIVYKTVKEGIGFSKFISIGNMADVDFSELMEYLADDEESKAIALYIEGVKDGRKFMEAAKKVTKKKPVIVLKAGKSESGARAASSHTGSLAGSYKIYEAAFKQTGILVANTIDEMLSMARAFTQPLPKGNRVAIMTNAGGPGVLTADEIDKHGLKLANLEEETMQKLREFLPPMAAVKNPVDMIASARGEEYYKTAKLLLEDKNVDMLIAICVVPTFAGMTPTEHAEGVIRAVKEVNNGKPVLALFMAGYVSEPAKELLEKEGIPVYERPEDVGIAAYALWEIARRKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHH3</accession>
    <name>F0LHH3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467598.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01325"/>
    <dbReference type="EnsemblBacteria" id="ADT84300">
        <property type="protein sequence ID" value="ADT84300"/>
        <property type="gene ID" value="TERMP_01325"/>
    </dbReference>
    <dbReference type="GeneID" id="10041641"/>
    <dbReference type="KEGG" id="tba:TERMP_01325"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1326"/>
    <dbReference type="eggNOG" id="arCOG07509">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187363_0_0_2"/>
    <dbReference type="OMA" id="VPNEVWS"/>
    <dbReference type="OrthoDB" id="125302at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="76" mass="9176" checksum="10356D9787112B91" modified="2011-05-03" version="1">MTMQKGWTLKYHSKRDIEERLAFIKIYVEKLKENPDEVFRQQVRLVNSFLKAAKNYPLTKEAYLKIKGELRTKERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHK0</accession>
    <name>F0LHK0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multisubunit sodium/hydrogen antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_01352</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467625.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01352"/>
    <dbReference type="EnsemblBacteria" id="ADT84327">
        <property type="protein sequence ID" value="ADT84327"/>
        <property type="gene ID" value="TERMP_01352"/>
    </dbReference>
    <dbReference type="GeneID" id="44120411"/>
    <dbReference type="KEGG" id="tba:TERMP_01352"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1352"/>
    <dbReference type="eggNOG" id="arCOG08614">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2646114_0_0_2"/>
    <dbReference type="OMA" id="AVVKYAF"/>
    <dbReference type="OrthoDB" id="126964at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="8">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="82" mass="8860" checksum="A1F3C547F0D77FB8" modified="2011-05-03" version="1">MLGIIHELLLVLMVITALAVIEERDLVVAVVKYALLSLIFVLVLFQLKAPDVALSAIVVGAVIIGIFLFTIEEVEKSGGTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHM2</accession>
    <name>F0LHM2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps4</name>
        <name evidence="9" type="ordered locus">TERMP_00129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466404.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00129"/>
    <dbReference type="EnsemblBacteria" id="ADT83106">
        <property type="protein sequence ID" value="ADT83106"/>
        <property type="gene ID" value="TERMP_00129"/>
    </dbReference>
    <dbReference type="GeneID" id="10040447"/>
    <dbReference type="KEGG" id="tba:TERMP_00129"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.130"/>
    <dbReference type="eggNOG" id="arCOG04239">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089738_1_1_2"/>
    <dbReference type="OMA" id="ARQFITH"/>
    <dbReference type="OrthoDB" id="93256at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_A">
        <property type="entry name" value="Ribosomal_S4_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_S4/S9_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022802">
        <property type="entry name" value="Ribosomal_S4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="8">
        <location>
            <begin position="5"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="7">
        <location>
            <begin position="103"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="181" mass="21319" checksum="879F39F3DAC36625" modified="2011-05-03" version="1">MGDPKRQRKKYETPSHPWIKERLDRERVLMKKYALKNKKELWKHETQLKEFRRRARRLLAARGKQAEIERQQLLQRLTRLGLLPENAVLDDVLSLTIEDILERRLQTLVYKKGLARTIKQARQLIVHGHIEVNGQIIRSPSYLVLREEEDGITYAKTSPFAKESHPERVVIEQAKQAGEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHX7</accession>
    <name>F0LHX7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cadmium efflux system accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467675.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01402"/>
    <dbReference type="EnsemblBacteria" id="ADT84377">
        <property type="protein sequence ID" value="ADT84377"/>
        <property type="gene ID" value="TERMP_01402"/>
    </dbReference>
    <dbReference type="GeneID" id="26136897"/>
    <dbReference type="KEGG" id="tba:TERMP_01402"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1402"/>
    <dbReference type="eggNOG" id="arCOG01681">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_7_3_2"/>
    <dbReference type="OMA" id="YHVEHLR"/>
    <dbReference type="OrthoDB" id="111287at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="115" mass="13459" checksum="52D74DD02DF723FE" modified="2011-05-03" version="1">MTEVCKVYEEHLDKILKAREKLPEEELILEISDFFDALGNPTRLKILFALLEDELCTCDLSNITGLSVSAISHQLRILKDRKIVTYRKDGKNVFYRLDDEHIREILKVALKHMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI05</accession>
    <name>F0LI05_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NurA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01430"/>
    <dbReference type="EnsemblBacteria" id="ADT84405">
        <property type="protein sequence ID" value="ADT84405"/>
        <property type="gene ID" value="TERMP_01430"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01430"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1430"/>
    <dbReference type="eggNOG" id="arCOG00367">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_719269_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="51"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="382" mass="43155" checksum="E441F9D247A2CFCC" modified="2011-05-03" version="1">MIKQYRCDVFSKVDSYLKKLQSLKRDIRYYLDEEGLLRSSGEILEYRGIDPTVCGVDGAYAISKQIALDVVGIAAVAVEGLPPYEKRLWEKPHHIAKIFPVEHKSKTSTLATGLMFSYELELATKAPHNVVFIDGSLTTHLIKTGMSFSILDSEDIPSTLRDIYIERAEDTLKNYLKVVTSPKSDQVFAGVPKYSSRNEICMHLIENYPELLKVIPLNTYNDKALLSLILKPEEIVGPIRLQKYKEEGKWHLSGKTQMAKFIGPHYEDYVSRIISALEDLYVIYYKPSSSQPALRVEIPKNVAKNKARLSLVIKALQDQSKFPGIIEPYPLYLADLFVKHLGGALSEIKDIVLSDLAVLDLEMNPVDVLLAMHEYRSVGGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI23</accession>
    <name>F0LI23_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Archaeal histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466475.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00200"/>
    <dbReference type="EnsemblBacteria" id="ADT83177">
        <property type="protein sequence ID" value="ADT83177"/>
        <property type="gene ID" value="TERMP_00200"/>
    </dbReference>
    <dbReference type="GeneID" id="26135530"/>
    <dbReference type="KEGG" id="tba:TERMP_00200"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.201"/>
    <dbReference type="eggNOG" id="arCOG02144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192667_0_0_2"/>
    <dbReference type="OMA" id="CKHAGRK"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="67" mass="7421" checksum="C8C617AB778B7768" modified="2011-05-03" version="1">MAELPIAPIDRLIRKAGAERVSEEAAKVLAEYLEEYAIELSKKAVEFARHAGRKTVKAEDIKLAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI45</accession>
    <name>F0LI45_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466497.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00222"/>
    <dbReference type="EnsemblBacteria" id="ADT83199">
        <property type="protein sequence ID" value="ADT83199"/>
        <property type="gene ID" value="TERMP_00222"/>
    </dbReference>
    <dbReference type="GeneID" id="10040540"/>
    <dbReference type="KEGG" id="tba:TERMP_00222"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.222"/>
    <dbReference type="eggNOG" id="arCOG00701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_5_2"/>
    <dbReference type="OMA" id="NVPMEAI"/>
    <dbReference type="OrthoDB" id="51024at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="9"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="251" mass="28605" checksum="7EDF00D177B0C792" modified="2011-05-03" version="1">MPSWEENRVLILGHRGFMSKYPENSILAFVEAISAGADGIELDVWLTKDGKAIIMHDETLERTAKIKKKTKDVTLEEIKSADLGMGQRVPTLEEVFQVIPEDSLINIEIKDVDAAEESIKIVKKFDACDRVMISSFNIDALRKVREYSKDVRLGLLIDNEQIVPQIPKLKEELNLWSINAPMEGIPIIGFEKFKQALAWAKSLGLKVVLWTENDELFYVNDNLKRLVGFFDVVIVNDVVRMIDYLRSLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI89</accession>
    <name>F0LI89_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467717.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01444"/>
    <dbReference type="EnsemblBacteria" id="ADT84419">
        <property type="protein sequence ID" value="ADT84419"/>
        <property type="gene ID" value="TERMP_01444"/>
    </dbReference>
    <dbReference type="GeneID" id="10041760"/>
    <dbReference type="KEGG" id="tba:TERMP_01444"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1444"/>
    <dbReference type="eggNOG" id="arCOG03427">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120467_0_1_2"/>
    <dbReference type="OMA" id="VNSDFAT"/>
    <dbReference type="OrthoDB" id="122467at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EamA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="138" mass="15225" checksum="A700BEF2A27BB867" modified="2011-05-03" version="1">MTTYIFYALLSALFAALVAIFGKLGLENVDSTLATTIRAGVMFFFLLFFSLATGKLDLNLNTRFWIFIMLSGVAGALSWLFYFMALKNGNVSTVVAIDRLSIVFAVLFAWFIFKEEVTIRTLIGALLIVAGAIMVSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI96</accession>
    <name>F0LI96_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01451"/>
    <dbReference type="EnsemblBacteria" id="ADT84426">
        <property type="protein sequence ID" value="ADT84426"/>
        <property type="gene ID" value="TERMP_01451"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01451"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1451"/>
    <dbReference type="eggNOG" id="arCOG02508">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_292823_0_0_2"/>
    <dbReference type="OMA" id="GDDIACG"/>
    <dbReference type="OrthoDB" id="1070at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027552">
        <property type="entry name" value="CGP_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04288">
        <property type="entry name" value="CGP_CTERM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="676"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="766"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="853"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="940"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1005" mass="110331" checksum="E6AB995FE7349BEE" modified="2011-05-03" version="1">MCLRRKLSIPLVFLALFSFIIPEIYAGDADLTEAIPGAVIKDDEIIVGDRGDYLLMYEDEKGNLLYQFGRNYEIWDEITAGDVNGDGKAEIIHGDRDTDKLYILTRSGQILGKKNVGFEAGDDIACGDVNKDGKDEIIFADRNDWIKVYDENFNELSKFKIDFSDEDAIASGDIDGDGKDEIIWGDHSKNLIIVYDMYGNSIMSFSTDDYFDLTGRDEIAVGDVNLDGIEEIVVATRDKGNYGKSKGIHVFKVAEGKAYEISSFRIEYAKGDRMAIGDVNRDVVDEIVWASRTGKIKVYNYQGELLNGPNGFSSRFQHGAGLAVGDVDGNSITVGPPIHSTMSITNKVITVINAPPVDFDVINETGVFYATYMTKNTRTLSVSVKAVSDISLTVGVKLGVGLKGVGETELGLKTKVQQKFEATRGSEHVFSETYEITADMADAILHVSTDYDVYEFPIISPPELAVINGEQQYILVTVPKGKPHIHLSNYNSDIHRIGDITTYPTKPEDLPNYEVSNELFHYTIEAGEVGGGGGFYMKDANWKETKNTFSLSVSMEAKTSGKIGLFGSYEVNLQGNYGKSRITTHKVSISNETRVHIEYNGRIEDRDKWYNATAIAYLDSEDGHLVLEFIVPSMGSYYKTRSLSPLGFSYDQIKLISKPLPGNIIIPPLVLNMFSSSCKIDASHSSGKAPLKVDFQISTSGGGGVKNWTLSFGDGTVLRNTGNVSTLLSHTYSEEGNYRVTMNIENLWGYKANCSKEITVLPNKVPKAMFDISPSPAKVEDEVNFIDSSEDEDGSIVKWNWNFGDGTTSTERNPKHSYSSPGMYTVTLTIEDDSGMKASYSKGITINPKNQLPTADFTFLPKEPKTGETVNFVDKSHDSDGNIVSWNWDFGDGTTSTKREPIHTYSSPGNYTVKLVVKDDKGGEDEIAINIVVKVAPTLTETETTSSKTETPTESTPTSHSTTSTSTTSSSSASSPLPTETQTGTCGPAFLVALMLLSLVSRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LID6</accession>
    <name>F0LID6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane bound hydrogenase MbhH-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01491</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01491"/>
    <dbReference type="EnsemblBacteria" id="ADT84466">
        <property type="protein sequence ID" value="ADT84466"/>
        <property type="gene ID" value="TERMP_01491"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01491"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1491"/>
    <dbReference type="eggNOG" id="arCOG01537">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_5_2"/>
    <dbReference type="OMA" id="AFPVNFW"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="7">
        <location>
            <begin position="72"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="133"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="509" mass="54809" checksum="27D9FE9F3C9A0E92" modified="2011-05-03" version="1">MLPFLIIIPLFGAFSMPLVKLISEKLRDIWAVIISAVTLGVATDVFYTIWKTNQIVVYTLGATTPLGKGVGFPIRIVWEVDLLGALIAVTIAFVSLLAIIYSLEYMKHDTGLDKYYTLILILELGMLGIVITGDIFNFYVFLEIMSIASYALVAFRNDTWEGIEAGIKYMFVGSLASSFILLGIALLYGQYGTLTMAYLSQYITREPTFVSKVALAFILGGLLFKSGAVPVHMWLADAHPAAPSSISAMLSGLVIKAGGVYAIARILFSIYSISLNIKAIGWIVIFFACLTLIVGNAMAVVQTDMKRLFAFSSVGQIGYILLGIGIGIAAYGTKVGDVALAGAIYHTVNHAIMKALLFLVAGAVLHQVGTKNLNELSGLARRMPLTSFAFLVGAAAIIGLPPLNGFASKWLIYESSALYNPFLAAIAILGTAFCTAAYIRVLFTFFGKESEKVKAAKDPGKAMVIPMILLIIAVIIMGLLPWQINDTIMLPTAKMLEESGKYVLAVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIG2</accession>
    <name>F0LIG2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle 54 kDa protein</fullName>
            <shortName evidence="8">SRP54</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">srp54</name>
        <name evidence="10" type="ordered locus">TERMP_00259</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="8">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466534.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00259"/>
    <dbReference type="EnsemblBacteria" id="ADT83236">
        <property type="protein sequence ID" value="ADT83236"/>
        <property type="gene ID" value="TERMP_00259"/>
    </dbReference>
    <dbReference type="GeneID" id="10040577"/>
    <dbReference type="KEGG" id="tba:TERMP_00259"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.259"/>
    <dbReference type="eggNOG" id="arCOG01228">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_2"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="OrthoDB" id="25871at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="9">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="189"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="247"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="448" mass="50129" checksum="2D56BA998F0EA6B1" modified="2011-05-03" version="1">MALESLGKALNAALKKLARAGSVDEVLIKEVVRDIQRALIMSDVNVKLVLDLTKKIQKRALEEKPPAGVSRREHIIKIVYEELTNFLGKEAKPIEIKEKPTILLTVGIQGSGKTTTVAKLARYFQKRGYKVGLVCSDTWRPGAYHQLKQLVEPYSIEVFGDPNEKDAVRLAKEGVEYFKHKGVDIIIVDSAGRHKEEKSLIEEMKQISDAINPHEVILVIDGTIGQQAYSQALAFKEATPIGSIIVTKLDGSAKGGGALSAVVATGAPIKFIGVGERIDDLEPFDPKRFVSRLLGLGDIQGLLEKFEELSKAQELKEEDLEKFMRGKFNLKDMYAQLEAMSKMGPLKQILQMIPGLGYSLPDDVVRVSEQRLRKFKVIMDSMTEEELEHPEIINYSRIKRIARGSGTTVKDVKELLEQYNQMKKFFKSMNKRSLNRMMKRLGMGGFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIG6</accession>
    <name>F0LIG6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">V4R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466538.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00263"/>
    <dbReference type="EnsemblBacteria" id="ADT83240">
        <property type="protein sequence ID" value="ADT83240"/>
        <property type="gene ID" value="TERMP_00263"/>
    </dbReference>
    <dbReference type="GeneID" id="10040581"/>
    <dbReference type="KEGG" id="tba:TERMP_00263"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.263"/>
    <dbReference type="eggNOG" id="arCOG01693">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688150_0_0_2"/>
    <dbReference type="OMA" id="KGCNIAL"/>
    <dbReference type="OrthoDB" id="38758at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004096">
        <property type="entry name" value="V4R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02830">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00989">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V4R" evidence="1">
        <location>
            <begin position="329"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="394" mass="45547" checksum="887BE1B44ECA8837" modified="2011-05-03" version="1">MISTGIQRLDDILKGGIREEHSVMFSGLFDEDHRILMHQFVFSLLSQDYKVLLVEFKQTPRSLIEWVKEYGIDYSSFMESEKLRILDGYTNIYSKMTVSGKDMLPNPLDLPITTAIIRDILIKEKYDFLVIDDLSILYAVLSSKEEFFKIIVRFINSISLEHVSTVASFMEELTSPDYYSLLTLPFGYVISVKNGKIHVLKAPHPLSSVTYFTYVKTERGIQPYGEYYETVERLKESLFLDEEGMLWAGNERIQLVEENSEATLIEGLFEYLGEEEAKRFLYFWGRKSFQEIGKIYAKVHKSLRHVLEKIFDETKISGGGMLEILQFSNDMIVIKGKNLFPRMPNFGSQVHLHYAGALAQIVEEISGSEWEGHEVKCEAKGDSYCEFVIKRKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIN6</accession>
    <name>F0LIN6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00333"/>
    <dbReference type="EnsemblBacteria" id="ADT83310">
        <property type="protein sequence ID" value="ADT83310"/>
        <property type="gene ID" value="TERMP_00333"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00333"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.333"/>
    <dbReference type="eggNOG" id="arCOG00398">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117042_0_0_2"/>
    <dbReference type="OMA" id="WLKGLNY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="11"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="190" mass="21902" checksum="25D7DEFAB7ED2AC1" modified="2011-05-03" version="1">MAKTIQIRKFMLIDNAYKERILRGKKVTTIRYGKYEAKPGSEVYIVITPSDTAIAKAKIKGITKKKVKELTNEDAKRDGFKDVRELLRVLNKIYGELYGDDEITIIEFEVIKQFKEGVPLKWLKGLNYRDPYEIAKLYVENNLKISPDVDLIVKKVHEEGLKAAVKRYGPKRVRGALLKAYHELYAKGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIQ3</accession>
    <name>F0LIQ3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0215 protein TERMP_01530</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0215 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467803.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01530"/>
    <dbReference type="EnsemblBacteria" id="ADT84505">
        <property type="protein sequence ID" value="ADT84505"/>
        <property type="gene ID" value="TERMP_01530"/>
    </dbReference>
    <dbReference type="GeneID" id="10041846"/>
    <dbReference type="KEGG" id="tba:TERMP_01530"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1530"/>
    <dbReference type="eggNOG" id="arCOG00928">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095956_1_0_2"/>
    <dbReference type="OMA" id="LRLAHMI"/>
    <dbReference type="OrthoDB" id="103162at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00582">
        <property type="entry name" value="UPF0215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002802">
        <property type="entry name" value="DUF99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39518">
        <property type="entry name" value="PTHR39518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01949">
        <property type="entry name" value="DUF99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006380">
        <property type="entry name" value="UCP006380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="195" mass="22048" checksum="2365A174D94E25F5" modified="2011-05-03" version="1">MIRKVKPQIRVIGFDDGTFSFKSKVERNKTILIGVVMKGSQDVVGILCRWIEVDGRDATEKMIDAIVNSRFKDLRVIMLKGITYAGFNIVDIEKLSKETGLPVIVVIRKRPELKAMENALKKHFPDAEERIRLLRKGGEIKELIPGKLFYQAYGIEPKTAEEIIKITQKSSLIPEPLRLAHMIASAVMTGESKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIR0</accession>
    <name>F0LIR0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467810.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01537"/>
    <dbReference type="EnsemblBacteria" id="ADT84512">
        <property type="protein sequence ID" value="ADT84512"/>
        <property type="gene ID" value="TERMP_01537"/>
    </dbReference>
    <dbReference type="GeneID" id="26137049"/>
    <dbReference type="KEGG" id="tba:TERMP_01537"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1537"/>
    <dbReference type="eggNOG" id="arCOG01296">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_3_2"/>
    <dbReference type="OMA" id="VDNFPGY"/>
    <dbReference type="OrthoDB" id="41707at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="18"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="329" mass="36327" checksum="81BA9D15950FF11E" modified="2011-05-03" version="1">MFSLTGFSKGKEEKTTWDVVIIGAGPAGYTAAIYTARFGLETIIISKDLGGNMALTDLIENYPGFPEGISGSELNRRMYDQVRKYNVDVIFDEVERIEKGECPYYEGKCYWMVYTKNGRVYKAKTVIIAVGAEPRKLNIPGEKELTGRGVSYCATCDGPLFVGKEVIVVGGGNTALQEALYLHSIGVKVTLVHRRDKFRADKILQDRFKEAGIPAILNTVVIEIKGKEKVESVVLKNVKTGEVFEKKVDGVFIFIGYEPKTDFVKHLGITDEWGYIPVDMYMRTKAPGIFAAGDITNVFKQIAVAVGQGAIAANSAKEFIESWMEKNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIR6</accession>
    <name>F0LIR6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01543"/>
    <dbReference type="EnsemblBacteria" id="ADT84518">
        <property type="protein sequence ID" value="ADT84518"/>
        <property type="gene ID" value="TERMP_01543"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01543"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1543"/>
    <dbReference type="eggNOG" id="arCOG05839">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_679022_0_0_2"/>
    <dbReference type="OMA" id="NSHIGWY"/>
    <dbReference type="OrthoDB" id="64883at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027553">
        <property type="entry name" value="Heavy_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027556">
        <property type="entry name" value="Heavy_Cys_GCP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04289">
        <property type="entry name" value="heavy_Cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04292">
        <property type="entry name" value="heavy_Cys_CGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="402" mass="45222" checksum="8B90B5A453AD1602" modified="2011-05-03" version="1">MKRYAVAFILILALLPFAQACFSPTDNLAVEVYFNKPGIEYNLEPLTNAENVLIEDGRLIYHSHYDERVAVILWEDNGLHLRIEIPVKNWNSTVLSAKFTTPIIFPENSIEKAKELGWEVEGKHAFRRENILVQITPQKGRECSKDSDCSTGGCSGEICTTRENATKVVSICVYRDWYECLKLTSCGCVNGVCTWKPNGAFEQCLKEHGIDPNKVIKMPQADVYIAIYGQKELSEEKRAEIKELFSVLGISCVLENIKFEKRVTSMPEGIVNPYTFNFKEALRVEIEWLKESGILKISDEDIEEIVKVAKRGYAGYNSHIGWYETKDGKYAWIPYYESKDAKLVKCLGKPMTYQLPKGTVELGKPSPSQSPSTPKSPTSSAICGTGIVVLGVLLPLSLRRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ06</accession>
    <name>F0LJ06_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00375"/>
    <dbReference type="EnsemblBacteria" id="ADT83352">
        <property type="protein sequence ID" value="ADT83352"/>
        <property type="gene ID" value="TERMP_00375"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00375"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.375"/>
    <dbReference type="HOGENOM" id="CLU_3302925_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="39" mass="4175" checksum="755E99BBCCEE0116" modified="2011-05-03" version="1">MSLSFPLFSETLKTSFANNQGVKTILGDGGNAKESKRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ36</accession>
    <name>F0LJ36_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="7">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="7">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pheS</name>
        <name evidence="9" type="ordered locus">TERMP_00405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466680.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00405"/>
    <dbReference type="EnsemblBacteria" id="ADT83382">
        <property type="protein sequence ID" value="ADT83382"/>
        <property type="gene ID" value="TERMP_00405"/>
    </dbReference>
    <dbReference type="GeneID" id="10040723"/>
    <dbReference type="KEGG" id="tba:TERMP_00405"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.405"/>
    <dbReference type="eggNOG" id="arCOG00410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_2_2_2"/>
    <dbReference type="OMA" id="QIEGWVM"/>
    <dbReference type="OrthoDB" id="22747at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00282">
        <property type="entry name" value="Phe_tRNA_synth_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022917">
        <property type="entry name" value="Phe_tRNA_ligase_alpha_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="250"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="503" mass="58310" checksum="89183197A84C7133" modified="2011-05-03" version="1">MELSYHEKLTLIKLKDLRKAKFEDLVKETGLDQVAVMRAVLWLQSKGLAKLHEKKKKVVKLTETGKKYAEIGLPERRALMLLAERGRVTLKDLTEVLSEDELKPIIGILRKEGWATVKKEDGKLVLEVTEKGREALNLDRPIDKALKILAENGEVEAKEIEDLISLNELKRRKVAEDELKTEREVEITEKGLKLAEKGLELKEEISILTPELIKSGKWRNVEFKRFNIKAPVKRIYPGKKQPYRAFLDKIRRKLIEMGFIEMTVESLIETQFWNFDALFQPQNHPARDWTDTYQLKYPKYGFLPEEELVERVKASHEHGWITGSRGWGYRWDPRMAMMLMPRAHGTALSARQLAKDVQIPGKYFAIQRVFRPDVLDRTHLIEFNQVEGFVIGEDLTFKHLLGILKRFATEVAGAKKVKFLPDYYPFTEPSVQMSAKHPELGWVEFGGAGIFREEMTKPLGIDVPVIAWGIGIDRLAMFKLGIDDIRYLFSYDLKWLREAKIIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ80</accession>
    <name>F0LJ80_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-layer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="10041943"/>
    <dbReference type="KEGG" id="tba:TERMP_01627"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1627"/>
    <dbReference type="eggNOG" id="arCOG10106">
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    <dbReference type="HOGENOM" id="CLU_557387_0_0_2"/>
    <dbReference type="OMA" id="WVSNKAW"/>
    <dbReference type="OrthoDB" id="15293at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022651">
        <property type="entry name" value="S_layer_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05124">
        <property type="entry name" value="S_layer_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S_layer_C" evidence="1">
        <location>
            <begin position="330"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="487" mass="54763" checksum="04B310F53CB4B35C" modified="2011-05-03" version="1">MRKVLSVILSVLFLVSVAGAVQGFNFKVNSTNSIIVLPTTKIVNGQPLHIGEDAITGSKLGALLVLKGIREVTYSTYVDVPIEYHSVLIQDNNQYYKLNSVDMPDVGINVGDSPVGDTIVVAVNFSRVLYNDTIKKAQFNDKSVEIIFNENTTPLNLGGETAKIVSTVVDGKDTMYIYSYEENSGSKALGETLTINGWKIKFRDIDTEQEKTLVDISFPSGFVRTDTLYKNKYYILYVDANGDEDFEPFDSYPSARIQELLQAGIKKMLIISPTDFFVGIGGTRQVTYKYEYYEKVRMYQDGEVYEGQWIWDIDPTNNLFVLYLHVDPDNNFPKVVLDDGQMLKLPIDGLNIQPVFAKDENGEITGIAGYRFVRIDTVKRKVTVKTVKADVIDDVNKLIIEDTQLTKLPSDKNVIIVGGWVSNKAWKLLEQVYGSSTIQSIKDEIMNKGYVVKVLDNPNNPEYKVIILAGKDYTLTRKAVEEFMNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ91</accession>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="protein sequence ID" value="ADT84613"/>
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    </dbReference>
    <dbReference type="GeneID" id="26137164"/>
    <dbReference type="KEGG" id="tba:TERMP_01638"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1638"/>
    <dbReference type="eggNOG" id="arCOG05816">
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    </dbReference>
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    <dbReference type="OMA" id="DKGIDMS"/>
    <dbReference type="OrthoDB" id="115861at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018716">
        <property type="entry name" value="DUF2240"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09999">
        <property type="entry name" value="DUF2240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="132" mass="15424" checksum="430673C1FFD0DA2E" modified="2011-05-03" version="1">MKELKNAILYKGSNEFTKQELIGILVVKLRLMSVKEAKELIEGSIERGIIEERDGKLIINEEILEKEEKEEDIFTKMIAYIARKLGWSEFEVLEDIKKFSERYGTLDKRIVAYLYGVDKGIDMSKFKDKLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ92</accession>
    <name>F0LJ92_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01639"/>
    <dbReference type="EnsemblBacteria" id="ADT84614">
        <property type="protein sequence ID" value="ADT84614"/>
        <property type="gene ID" value="TERMP_01639"/>
    </dbReference>
    <dbReference type="GeneID" id="26137163"/>
    <dbReference type="KEGG" id="tba:TERMP_01639"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1639"/>
    <dbReference type="eggNOG" id="arCOG01943">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_13_1_2"/>
    <dbReference type="OMA" id="ICGTLAN"/>
    <dbReference type="OrthoDB" id="79386at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="178" mass="19917" checksum="3CC0FFCE8F419CC2" modified="2011-05-03" version="1">MEALIIVDMQKDFMPDGALPVPDGDKIIPKVEEYIKKFKEKGALIVATRDWHPPNHISFKEQGGPWPRHCVQNTEGAEFVVKLPEDAIIISKADKPDKEAYSGFEGTNLAETLRKRGIKKVYICGVATEYCVRATALDALKYGFEVYILKDAIKGINPEDEEKALKELEDQGAKIITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJB8</accession>
    <name>F0LJB8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01665"/>
    <dbReference type="EnsemblBacteria" id="ADT84640">
        <property type="protein sequence ID" value="ADT84640"/>
        <property type="gene ID" value="TERMP_01665"/>
    </dbReference>
    <dbReference type="GeneID" id="10041981"/>
    <dbReference type="KEGG" id="tba:TERMP_01665"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1664"/>
    <dbReference type="eggNOG" id="arCOG02444">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559766_0_0_2"/>
    <dbReference type="OrthoDB" id="81826at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018646">
        <property type="entry name" value="12TM_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09847">
        <property type="entry name" value="12TM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="486" mass="56317" checksum="4845F31F3B306F05" modified="2011-05-03" version="1">MEALVRELFFQEFRHRLDDYGTEKFRRFLKRAPLVQLSFTSTVFLIFSFVFLRAEKLLGESEIVFASLVSALLVFVVVISSFLVIEFLYSLARTRALQPLLLLPINVEFLPLKTWLKYYTIPLIFLFLPFFLKMLRYHWMALIVAMMWFIISIAIGWGFGCLIAIFSLRMRKIGILRDIFSLTLRVAFILFLTLFIFYGVIFPEIFKSVFQFRALSTYFFPIAQATTLVLSFQGILQWKVIMTYATLSFLILLFGNHLIMLHLIEERQISKIGKSFEAKLLPKMFSIIAKDVKLALRRSSSLFILLMPFIFLVPLTFLRDDRLVTWVLIIGSFAVITSLNVQILLMEEYKSGWFMFSLPINWKEFRNAKALTSFILFAPILLVSVVVAKVDISGSSLFLFIFGAFTNLLMAKVITLWLTRNMKDEYTLMPAYLTIGDTLVIFGLAFFLVNFPASLFYLLHGYIRIFAGVVFLALEGILMIILYKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJD0</accession>
    <name>F0LJD0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00419"/>
    <dbReference type="EnsemblBacteria" id="ADT83396">
        <property type="protein sequence ID" value="ADT83396"/>
        <property type="gene ID" value="TERMP_00419"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00419"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.419"/>
    <dbReference type="eggNOG" id="arCOG01051">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_1_2"/>
    <dbReference type="OMA" id="VINTCDY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="308" mass="33912" checksum="3614B9CAC5032EC2" modified="2011-05-03" version="1">MDKIIESFREAFGRALVEMGKENENVVVLDADVKGSTKTIYFEKAFPGRFFQIGISEQDLISTAAGFAIAGKIPIASAFAAFMMRAWEQIRNTVARDNLNVKIVTTHSGFSDFMDGSSHQCLEDIALMRVLPNMRVLVPADAYATRVLLEQMVESEGPFYMRLGRDYTVKVYDGEELKVGKAEILREGEDVFLIACGFMVSVALEVAEKLKDLSVGVADFHTIKPLDENTLLKIAKKVSLIVTLEEHSIFGGLGGAVAEVLSEKIPKRVIRIGAEEFGRSSRDYLALLDFYGLSADKIAKRIVKAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJH0</accession>
    <name>F0LJH0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="6" type="ordered locus">TERMP_00459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466734.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00459"/>
    <dbReference type="EnsemblBacteria" id="ADT83436">
        <property type="protein sequence ID" value="ADT83436"/>
        <property type="gene ID" value="TERMP_00459"/>
    </dbReference>
    <dbReference type="GeneID" id="10040777"/>
    <dbReference type="KEGG" id="tba:TERMP_00459"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.459"/>
    <dbReference type="eggNOG" id="arCOG01704">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_0_3_2"/>
    <dbReference type="OMA" id="LDMIVAN"/>
    <dbReference type="OrthoDB" id="56027at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="5">
        <location>
            <begin position="193"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="198"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="404" mass="44844" checksum="908DF783CB46FFF6" modified="2011-05-03" version="1">MLHHVKLIYATKSRKLVGRKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMSESAQKIIHPYAMEFATGNPVVTEITGFIEHVELCGEHENKADLVLVCPATANTISKIACGIDDTPVTTVVTTAFAHTPIMIAPAMHSSMYEHPIVKENIEKLKKLGVEFIGPKFEEGKAKVASIDEIVYRVIKKLHKKDLKGKRVLVTAGATREYIDPIRFITNKSSGKMGVALAEEADFRGAEVTLIKTKGSVPSFVGNQIEVETVEEMLHAIENELMSKKYDVVILAAAVSDFKPKEKAEKKIKSGQTLILELVPTPKIIQRVKEIQPDVFLVGFKAEYGVSEEELIAQARNQIEKAKSDVVIANKGEIAFGSEENEVYWVTKDKVEKFPRMNKRELAEKIWDKIVEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJJ4</accession>
    <name>F0LJJ4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ph1570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466758.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00483"/>
    <dbReference type="EnsemblBacteria" id="ADT83460">
        <property type="protein sequence ID" value="ADT83460"/>
        <property type="gene ID" value="TERMP_00483"/>
    </dbReference>
    <dbReference type="GeneID" id="10040801"/>
    <dbReference type="KEGG" id="tba:TERMP_00483"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.483"/>
    <dbReference type="eggNOG" id="arCOG05765">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1656975_0_0_2"/>
    <dbReference type="OMA" id="MLCEEKL"/>
    <dbReference type="OrthoDB" id="98954at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023110">
        <property type="entry name" value="PH1570-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036807">
        <property type="entry name" value="PH1570-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09638">
        <property type="entry name" value="Ph1570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ph1570" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="157" mass="18288" checksum="C8CF28E59E37EBB2" modified="2011-05-03" version="1">MQCEEKLEVFENGFADGKFNLRIEFYGSDARKILLAIIYELYLPDYGKEYVYPFECAKEFWGIYMDASEVEPEELKLGKPKFVSRAVMDKLEAILENIEAPREVKENISLEKAEIYKLKGGLLALGKNFLLDGIKNRLFIFNKPSARELLLKYIGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJK3</accession>
    <name>F0LJK3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TBPIP_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00492"/>
    <dbReference type="EnsemblBacteria" id="ADT83469">
        <property type="protein sequence ID" value="ADT83469"/>
        <property type="gene ID" value="TERMP_00492"/>
    </dbReference>
    <dbReference type="GeneID" id="26135993"/>
    <dbReference type="KEGG" id="tba:TERMP_00492"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.492"/>
    <dbReference type="eggNOG" id="arCOG05837">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1237956_0_0_2"/>
    <dbReference type="OMA" id="FWQFYKC"/>
    <dbReference type="OrthoDB" id="57281at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043112">
        <property type="entry name" value="TIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029125">
        <property type="entry name" value="TIP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038230">
        <property type="entry name" value="TIP_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15517">
        <property type="entry name" value="TBPIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TBPIP_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="224" mass="26462" checksum="E60864C7C883AD85" modified="2011-05-03" version="1">MKYSELDSRLRKVYSRIRTLDDYHWDLSGDKIIGRHKKSDLKIRIRVANSREEAEKLSEVKEGEGLDIVVVPNKGTFYIHNGTFIMTSKFLRGTLVDINDHIVWRGFKVVEQDGKLMQEDFYEYLGGRFIEHLKNNMTIGQDFVFWQFYKCEKCGKYVDIDSVRSHLKEHGIKIEDKDEMMYEVFEISIIDGKVYDKFGKEVKEDKLSEEAKDFIKETLESFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJL3</accession>
    <name>F0LJL3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467953.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01680"/>
    <dbReference type="EnsemblBacteria" id="ADT84655">
        <property type="protein sequence ID" value="ADT84655"/>
        <property type="gene ID" value="TERMP_01680"/>
    </dbReference>
    <dbReference type="GeneID" id="10041996"/>
    <dbReference type="KEGG" id="tba:TERMP_01680"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1679"/>
    <dbReference type="eggNOG" id="arCOG00271">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_9_1_2"/>
    <dbReference type="OMA" id="GVQAFYF"/>
    <dbReference type="OrthoDB" id="40281at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="146"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="282" mass="31541" checksum="CC257A29A8822171" modified="2011-05-03" version="1">MKRGYLLVFLAASMWGTLGIFAKLLYQFNLDTFTVVFYRVVIAFFLLLIYNSSKGLKIKKERLPFYAFYGFFSIFLFYVLYFYTVRISSVSLAVLLLYTAPIHSTILGYLVFKEKVTPTKSIALIMAVSGVLFVVNPNNERISILAIVLGLLSGVTYALYGVLGKMAVRNENPEEALLYTLGFGALFLIPFSNFKIPLNAVPYIFALAFFPTFLAYILYNTALREVEVSKASIIATIEPVVALILAYLVFNEVLTLKQLFGAALIIGGSMLIHLDDIIGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJN4</accession>
    <name>F0LJN4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">V-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_01701</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467974.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01701"/>
    <dbReference type="EnsemblBacteria" id="ADT84676">
        <property type="protein sequence ID" value="ADT84676"/>
        <property type="gene ID" value="TERMP_01701"/>
    </dbReference>
    <dbReference type="GeneID" id="10042017"/>
    <dbReference type="KEGG" id="tba:TERMP_01701"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1700"/>
    <dbReference type="eggNOG" id="arCOG04138">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025558_1_0_2"/>
    <dbReference type="OMA" id="MAVNIMA"/>
    <dbReference type="OrthoDB" id="14889at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="563"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT84676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="659" mass="75740" checksum="57E312809CD5D4C8" modified="2011-05-03" version="1">MFRPEEMVKIELISINRYKDRLLTYLHEEGVIEIRELDVEIAQKDVPNEFYRKATSYSIGISRLVEFLETYREEKKSGIKEFFFPPMKSKRKYKYKSIEDLVKDVERFLENIEPQIKQVESRISSINTEIERIKNNMAVLELLSALNIDISYLRPTEKIEIVVGFVDRDKYSPLIEELTKTLEGKVAYVSKELKARYLVVFAILKGDYERANPILAKYAFERIEVPEGKGTPREVMREYQHQLAEKEKELTKAEKEAKELARKYYDDVVFYQELMENERDKANILNNLVRTNMTFAMLGWLPRKDVPRVVEGIKRITEGKVYINIKEPTKEELEEVPIKLKNPKFIAPFEMLTEMFGVPKYNEIDPTPILAFTYSFFFGFMLTDFMYGLLIGTVAALLVKGHKHLKDGTWKFANILLWSAFFTMLMGIFFGSYFGNILDLAGFHVWRKLDAMRDALIVLEIALAIGIFHLFIGYTLGFIVKLKNRQIKEAVLEQLSWMLIILGVILFALSMVGIGNAEVAKVVFGAGFVLFAVSEFQSDLPIPMKLLMTISDFFGFVGNWLSYARLMALALATSGIAMVVNIIVQMIWGLRIGPVPLGIAVGLVVFIGGQIFSTAINALGAFVHALRLHYVEFFGTFYSGEGKRFEPFKSRREVSELEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJP6</accession>
    <name>F0LJP6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Histone acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">TERMP_01713</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467986.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01713"/>
    <dbReference type="EnsemblBacteria" id="ADT84688">
        <property type="protein sequence ID" value="ADT84688"/>
        <property type="gene ID" value="TERMP_01713"/>
    </dbReference>
    <dbReference type="GeneID" id="10042029"/>
    <dbReference type="KEGG" id="tba:TERMP_01713"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1712"/>
    <dbReference type="eggNOG" id="arCOG01361">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025983_2_1_2"/>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="OrthoDB" id="7724at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="PTHR11135:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="70"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="420"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADT84688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="589" mass="69065" checksum="3500A425DDC2D56D" modified="2011-05-03" version="1">MDAYRKACEEIARMIISGEIKSREELNKVKVRVARKYHLSKLPGNADILRVMSKDDREKFKDFLKKKPTRTISGVAVVAMMTKPFPCPHGRCIYCPGGPSEGSPQSYTGKEPSALRAIQSAYHPYIIMLRRLKQLYDIGHDIDKVEVIVQGGTFPAMDLDYQEWFIKNAFKAMNDFPYFRDVENLEEKLIRVLVKKDHSVFDEDPKFKAAWERTHKKKYYYLEDEQRKNEKAKVRMVGLTIETRPDWSFERHIDRMLAFGTTRVELGVQTVFNFIYERVKRGHTVEDVVRATQLLKDAGLKVNYHMMPGLPGSNFERDLKAFQIIFEDSRFKPDMLKIYPTLVTEDTILYKWYKEGKYRPYTTEEAVRLLVEVYKIIPKWVRVMRIQRDIPVPLIAAGVKHSNLGQLVFNELIREGIRPREIRFREVGHVMQKFGIQPEVEHIKLLREDYEASEGREIFLSFEDVKNDILIGFLRLRIPSEKAHRKEINCCPSAIVRELHVYGPLVPIGGRPKYEWQHRGYGRELLAEAEKIAREEFDVKKMLVISGVGVREYYRKFGYRKDGPYVSKRLDKSYADFEKSREFDAHLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJP7</accession>
    <name>F0LJP7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467987.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01714"/>
    <dbReference type="EnsemblBacteria" id="ADT84689">
        <property type="protein sequence ID" value="ADT84689"/>
        <property type="gene ID" value="TERMP_01714"/>
    </dbReference>
    <dbReference type="GeneID" id="10042030"/>
    <dbReference type="KEGG" id="tba:TERMP_01714"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1713"/>
    <dbReference type="eggNOG" id="arCOG04454">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037423_3_0_2"/>
    <dbReference type="OMA" id="HGLFWRG"/>
    <dbReference type="OrthoDB" id="40682at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="252" mass="27779" checksum="12B8709BBAE66855" modified="2011-05-03" version="1">MASRDEIVSFLDEYLNIKAFPDKSKNGLQVEGKSEVNTIAFAVDACLDTFVKAKAFKADMVIVHHGIVWGGVDYITGLIQKRLKFLLENDINLYVAHVPLDAHPEVGNNAQLLKLLDLEPKEPFGDYGGVTIGFIGEFEEPKPLPLIAQILVEKLKIDYVKSYEFGKQEIKRIGVISGAGGFAIEEAVKKNVDLFITGEFIHGSYRTAEDLRLSVLAAGHYATETLGVRALMPLLRGKFGVRTVFIDNPTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJV2</accession>
    <name>F0LJV2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribose ABC transport system RbsC-like permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466787.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00512"/>
    <dbReference type="EnsemblBacteria" id="ADT83489">
        <property type="protein sequence ID" value="ADT83489"/>
        <property type="gene ID" value="TERMP_00512"/>
    </dbReference>
    <dbReference type="GeneID" id="10040830"/>
    <dbReference type="KEGG" id="tba:TERMP_00512"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.512"/>
    <dbReference type="eggNOG" id="arCOG00260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_0_2_2"/>
    <dbReference type="OMA" id="FRMNLFN"/>
    <dbReference type="OrthoDB" id="57686at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="344" mass="36316" checksum="F7FBE286BFF781CD" modified="2011-05-03" version="1">MKADKLSNIIKPLLESLIAIIIGVVIGAVVLKVSGYSPVEAYVALVKGAVGSIYGWSMTLSSATPIILTGLTFAISARTGIFNIGAEGTVYFGAIAAIVFTNMFANPVLGLIGGIIAGILWALPAALLKVYRGVHEVISTIMLNWIAFYTALYLVLGPLANPNDPNKTLEVPTSARLPLLMKGSELSLAFIIAIVAAVITYYILWHTVLGFELRASGYNERAAQYGGINPKRAIIWSFVIGGIMSGLAGATEVMGRPPSYAISQGMANIYGYGFDGIGVSLVGRNHPIGIIFSGIFFGALKAGATYMQIDAGVPLEMVKVVQGIIVVAVAVPGLWDLVKKVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJX0</accession>
    <name>F0LJX0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00530"/>
    <dbReference type="EnsemblBacteria" id="ADT83507">
        <property type="protein sequence ID" value="ADT83507"/>
        <property type="gene ID" value="TERMP_00530"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00530"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.530"/>
    <dbReference type="eggNOG" id="arCOG02491">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_716933_0_0_2"/>
    <dbReference type="OMA" id="WKGHISS"/>
    <dbReference type="OrthoDB" id="61612at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="393" mass="44402" checksum="E45A9929C30BA83D" modified="2011-05-03" version="1">MKKRWIANFVLLLLALYSANYAKVISEKDPVLNTLWRLNFGNFEENIAGIKFIDSRIVVATSYRGIAKHAKNGHLIIVDEKGNVIGNTTLLHLVASFDASKRIIALGTANFKWLNESTFTFSPFYLIAYSPNGSELWRRKFNATSVSTAGDLIVARGYIKNGSIVRVFDIGGNELWSLDFGDKVTTNGKVVAVAEKGKIYLFSRNGKLIKAFNPWKGAVARMGLTDDGKLVVVFYSRDGQFLGVYDRNGNFLWGKTFLHVEDFAISQKYLLIYDGVLHIFDWSGRELWSNTKYHPLYPEIGIALGKIALSPDGKFIAYGNAGVKFIINPLFDRDKDGILDENDAIPINNGLFLRIVMTLIVGGLALWVNLWERKKEREEARKRYEEIKNRLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK12</accession>
    <name>F0LK12_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative adenylate kinase</fullName>
            <shortName evidence="2">AK</shortName>
            <ecNumber evidence="2">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466847.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00572"/>
    <dbReference type="EnsemblBacteria" id="ADT83549">
        <property type="protein sequence ID" value="ADT83549"/>
        <property type="gene ID" value="TERMP_00572"/>
    </dbReference>
    <dbReference type="GeneID" id="10040890"/>
    <dbReference type="KEGG" id="tba:TERMP_00572"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.573"/>
    <dbReference type="eggNOG" id="arCOG01038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079096_0_1_2"/>
    <dbReference type="OMA" id="QCEIFGT"/>
    <dbReference type="OrthoDB" id="110798at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="PTHR12595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="LID" evidence="2">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="180" mass="20089" checksum="1A504444E62F78A6" modified="2011-05-03" version="1">MIIAVSGTPGVGKTTVAKLLAEKLGYMYVDLKKFAIGHEIGEIKGDELEVEIDELAYFIEKELKGKNVVLDGHLSHLMPADQVIILRLHPKIIGERLKERGYSREKISENVEAELVDVCLVEAIDTHENVIEVDTTGKTPEQVVEEILDLLNKGVKKRVGIVDWTQVYEEVIPYLNLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK19</accession>
    <name>F0LK19_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01756"/>
    <dbReference type="EnsemblBacteria" id="ADT84731">
        <property type="protein sequence ID" value="ADT84731"/>
        <property type="gene ID" value="TERMP_01756"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01756"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1755"/>
    <dbReference type="eggNOG" id="arCOG03704">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_651550_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="421" mass="48330" checksum="5C65CBF6283EB6E0" modified="2011-05-03" version="1">MVLKNVDAWGSNAVEEMLDEIGVPYDVLSSSEFAPLTASYLINKYDVIIIESDQPQNFYDELAPEMGDIEEFVKAGKVLQVHAANWGWHGGVWKTPLPGGVEIVKSYSNYDYNVEKDLWYYSTFASHGYLINLPQDAKIITVQSDVSYSQGAPDYNKPSAVTYQYGKGLVFATGLTLEYSAKYRGAMWKEFLKEIIIGSLEFKPAKKVEYFDYAMMNYIWYMLYNRYTEKFDEMYKETEQYNITNSTIPQVAEYKSLAEKHYELGWQYGHPIKGHIQALPHMRRAYMNIKKAYVLLDYSLKGLKHWQALENNNLTALIQQNNDASTLYWVGGPLNGTYKGIENAKATWSRFLGGNNVTKVDVYNITLAKSEDGMTGIRAVVIVSTKEGKRIPLRYEIYFKDDSIIEEWWIIDPSVLEMAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK30</accession>
    <name>F0LK30_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01767"/>
    <dbReference type="EnsemblBacteria" id="ADT84742">
        <property type="protein sequence ID" value="ADT84742"/>
        <property type="gene ID" value="TERMP_01767"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01767"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1766"/>
    <dbReference type="eggNOG" id="arCOG02969">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_414839_0_0_2"/>
    <dbReference type="OMA" id="VWRTDIN"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M1" evidence="1">
        <location>
            <begin position="464"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="616" mass="71227" checksum="78E77D617F4D8D2A" modified="2011-05-03" version="1">MQTANLSYTYYKDWLHNSTKYFEIYYPEEIYEDPTLQSKLNMLLLGADSTYESYSKLFGIKPQRAKIYLYPSKDSLKSITGKNTLWFVDYRNREIHIALIEESGMYSSFEIVSALLEFAAGRKLPDVIAVGFGVLNFRISMSPQEKAAKYVSIEQLKSLDLRKEYNETLYAEAGDLLRYIADIHGTQALIKTLKDGNIPTVNEKDFLEFLEVEDHETSNIEKTIITLNISIEQKKFEGAITYNNVTSQPYIYFRRTPRINIKEIKVNGKSVDFIQSFTIVIPMKNFKKGSIEIKYSGDYSKIEKIAPKRGYIEGQIKKNTAFLRGAFLRPMLNSVELFNVIEVRAKTDRGIVVAPGELISSNVWRISFPSGFSGVIPVFAGEFKKMELMNGYLTVYYMGLDDKTAEGYANLTAEILEFGVEHFGKPGYGKVKVVYPKEISISSLMLDTLAYSHNPLRYKYGYTYEVAHWWVPGTVTFDRNMSQFWFNLAFPWYYSLKYAQNISQESYRELRNYGISKYHRATKYGEKDVPLTEVWKVWRTDINLYYAVGAYKGALVLEKLEEYTGREAFFQSLREFFEKYRFREGNLNDFVAILEKNSGKPVKELFQNLTANTGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK36</accession>
    <name>F0LK36_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01773"/>
    <dbReference type="EnsemblBacteria" id="ADT84748">
        <property type="protein sequence ID" value="ADT84748"/>
        <property type="gene ID" value="TERMP_01773"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01773"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1772"/>
    <dbReference type="eggNOG" id="arCOG14519">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209490_0_0_2"/>
    <dbReference type="OMA" id="WEEEDEW"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="54" mass="7275" checksum="B7A3C83D1C5F509F" modified="2011-05-03" version="1">MQPPKKKRVEEIEEEEFFEEEEFEEWEEDWEEEWEEESWEEDWEEEEDWEEEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK71</accession>
    <name>F0LK71_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468079.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01808"/>
    <dbReference type="EnsemblBacteria" id="ADT84783">
        <property type="protein sequence ID" value="ADT84783"/>
        <property type="gene ID" value="TERMP_01808"/>
    </dbReference>
    <dbReference type="GeneID" id="10042124"/>
    <dbReference type="KEGG" id="tba:TERMP_01808"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1807"/>
    <dbReference type="eggNOG" id="arCOG02174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008861_2_0_2"/>
    <dbReference type="OMA" id="LHFVSHF"/>
    <dbReference type="OrthoDB" id="5636at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004767">
        <property type="entry name" value="SecD/SecF-like_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00921">
        <property type="entry name" value="2A067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="718"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="186"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="614"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="752" mass="84178" checksum="7B4E39782925CC5A" modified="2011-05-03" version="1">MLKKLAKIIVEYRIAFGLVAVFLLVVSFYGIAQLKFETNLANQLPENLPAVQDYFTVQNEFQSNEVLIVVVKIKDIKEGGVYDIRDPQVIQGIYDLEQKLRQHEYITNTMSIADVYINVLGRLPKNREESKFVLNMLPEDVRNQLISSDYTTTLIIATMNREKNTQALVRVYNEIQNDIDSVKFPQNVEVVQTGTVGILYKFLLFMQHDMYLTMAIAFLFVASLLLYFYRSPIKAVIPLIPLIFGVIMTLGFMGILRIPLDIETTTVGAMLVGMGIDYGVHVTNRYYEERKKGRSIEEAAEESIAETGKALLGAALTTIAGFSALSISVLPGLRRLSLALIMGLGLAALNAVVITPAIIILEEDLRKLITGHYEIPETRSHSGFIAKVFELMGRTVRDNPWKFLALVFVITLFFGYGLTMVTTEVRFEKMIPQNIPEIQVMNDVRYEFGGEDELDVLVKADDVRDPNVVKAIYIFEQSVLSDSYYNNAVEAESIADVVIRKYGYIPEDKEKIQQALEEYQGTPLVSSDYSMTLIRFKGNFMGVSQDEFRKIIRAFEEEIQNSEFPPGIEVSLAGDTYLNYALDKLTNTELQRISTYGTLLVVLIVILLFRSAKLSIAMATPMFLGALWTIGFMGWAGIPFSQVLAGTISMIVGLGVDYGMHLTHRFMEELEEGNPYPIVTAVKSVGPGIFIGALTTAGGFLALLFGELTPMHDFGKTLAFGIFASMLASYLVTPALLQIFYGKQIKKRGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK95</accession>
    <name>F0LK95_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466851.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00576"/>
    <dbReference type="EnsemblBacteria" id="ADT83553">
        <property type="protein sequence ID" value="ADT83553"/>
        <property type="gene ID" value="TERMP_00576"/>
    </dbReference>
    <dbReference type="GeneID" id="10040894"/>
    <dbReference type="KEGG" id="tba:TERMP_00576"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.577"/>
    <dbReference type="eggNOG" id="arCOG00842">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_2_2"/>
    <dbReference type="OMA" id="NIREVRW"/>
    <dbReference type="OrthoDB" id="79594at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="182" mass="21898" checksum="2E8A0C81F0D8B188" modified="2011-05-03" version="1">MQRPIILTGRKVSLGVLLREDIPKVWLWYNDRDVRRYLSSPDAVFYFEDEMEWYERIRREKEKHRVFAVIENRSDSLVGLIGVHKINHKNGHAEIGYFLSKQYWGKRYATEAVGLALEYCFKWLNLRKVYARVYEYNVASQRVLEKNGFKLVGRLKKHVHIPEEGFADVLFYELFKDEWESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK99</accession>
    <name>F0LK99_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coenzyme F390 synthetase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466855.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00580"/>
    <dbReference type="EnsemblBacteria" id="ADT83557">
        <property type="protein sequence ID" value="ADT83557"/>
        <property type="gene ID" value="TERMP_00580"/>
    </dbReference>
    <dbReference type="GeneID" id="10040898"/>
    <dbReference type="KEGG" id="tba:TERMP_00580"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.581"/>
    <dbReference type="eggNOG" id="arCOG02620">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_638769_0_0_2"/>
    <dbReference type="OMA" id="DFVIIYH"/>
    <dbReference type="OrthoDB" id="17209at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="77"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="429" mass="48742" checksum="D26C256A383B749D" modified="2011-05-03" version="1">MSKLVVGKTALEHLEELRYTAKKAAETTEFWKEKFSKIDIESMTPETLASEVKNIHILPKDLYNTERVWPSYIKNYDIFYTIVRTSGTTGQPKRIPYTIDDKRRVARQFIPWFYEYFEKGDRIASFFPPLPSASGIMGYGAVEELGAKVAYFQIPIQFIRMPDLLINELRSIKPTVLFSLTTTAFLLGLKLPEDIRNDIRVILVGGETLTEELAKATLENFPNAMIIDALGMSEEGAVGYRIVTKKKTTNFSFPESIIVLESIEEEEYKEYHKIYVTKIMKEGELTGLPLFNYDAGDLARVENGEIKSILRIKDAISLAGATLYLDQIISIVHRYPFLIDFVIIYHPLSPSNPKPKAIIRVGYVGEKPAGIEDEIRSLIYEGNNPVRYEVEDSKQAELIIEAVPAEKVREGLPQKPGKTKRIFIVGKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKB6</accession>
    <name>F0LKB6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NPCBM_assoc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466872.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00597"/>
    <dbReference type="EnsemblBacteria" id="ADT83574">
        <property type="protein sequence ID" value="ADT83574"/>
        <property type="gene ID" value="TERMP_00597"/>
    </dbReference>
    <dbReference type="GeneID" id="10040915"/>
    <dbReference type="KEGG" id="tba:TERMP_00597"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.598"/>
    <dbReference type="eggNOG" id="arCOG02087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024113_0_0_2"/>
    <dbReference type="OMA" id="PQGWDVK"/>
    <dbReference type="OrthoDB" id="22571at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM_assoc" evidence="2">
        <location>
            <begin position="597"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="730" mass="80603" checksum="CB77D654083B583D" modified="2011-05-03" version="1">MKKLSTVMLLFLLLSSIAQAQPWIEVFQGKVKIGETLIVGKYQIKITQEKETLMPYAIIYKGNEIIKVAGLNDTIEAEKIRIIPGSFNPESEEVFLVVQYEPSLFNEIKPKAGLSFSVNGYSIKILNSSEESAELSINGAEIIVKSNTSRVYDKLAFVYNGEILRVYYADVSVKLEEKRDYEIYYPFESLNVKAGEEIRIPISIINNGNDELQLPVQVTSKPPSWDAKIIDGQSGYDVSEIILRPKSSAQLFLDVKIPEDSEGIETVTFAVGEEIGAVKISVTKESGMEVKVPILGVEAEAGDTLKLPVEIINKGKEKEVTLEVKGKPQNWNVYFMLNGQRVRSALLDKQLSFTLVIETPRNADLGMHSIAFSVNGIEKRVSVFIYRTHKGEPAKLILTVKDEDGNFVGKAEVTVGNETAFTDSYGKVELEVKSGKYLLVIEKEGYEKFEKIIKLEDGEEKSLDVTLVKLPYYFTVEGQGDIVQVKTGGIGTYTFTINNLGKNDDTYSLSCLGIPEEWSAEFYMNEIPIKNVQVDAGKSKDVLLRIIPPFNAQPGNYNITISIKSSSGIERTLSLMVKLVGEYRIELYPQTPMISVKAGSEGRAVVNLQNSGTAPITNVKFEVSAPQGWDVKVVPSSIPELKPMVFGGGNVKAIAVPSQHTSVQVIVKVPKTTPAGTYQITITAKGDQAQASTQITVRVTQSSKSAYLGILILLLTFGAVIWMMRRVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKC0</accession>
    <name>F0LKC0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="3">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">panB</name>
        <name evidence="7" type="ordered locus">TERMP_00601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3 6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466876.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00601"/>
    <dbReference type="EnsemblBacteria" id="ADT83578">
        <property type="protein sequence ID" value="ADT83578"/>
        <property type="gene ID" value="TERMP_00601"/>
    </dbReference>
    <dbReference type="GeneID" id="10040919"/>
    <dbReference type="KEGG" id="tba:TERMP_00601"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.602"/>
    <dbReference type="eggNOG" id="arCOG00584">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_2"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="OrthoDB" id="60112at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="3 5">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5 6">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="291" mass="32817" checksum="2AED5CD8CAD58BEB" modified="2011-05-03" version="1">MREITPRKIMEMKGKEKIAMVTAYDYPSALIADKAGIDIIFIGDSLGMVVYGEPNTLNVSMEQMIYHTRAVAKAVKRALVLADMPFMSYEVSIEEGLRNAARLIQAGADAVKIEGGYDHKKLVKRLVRAGIPVMGHTGLTPQRYLRLGGYRLIGETEEEIEEILRDAKALEKSGAFAVVLEFVLADVAKLVTEEVKIPTIGIGSGPYVDGQVLVWHDLLGIYENVPPFVKKYANLGSMIQLALEEYRTDVKEGKFPEPKHYWEFLDKEEFEKKKKRAIEKLMRNSLEFFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKC9</accession>
    <name>F0LKC9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoglutarate oxidoreductase, delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466885.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00610"/>
    <dbReference type="EnsemblBacteria" id="ADT83587">
        <property type="protein sequence ID" value="ADT83587"/>
        <property type="gene ID" value="TERMP_00610"/>
    </dbReference>
    <dbReference type="GeneID" id="10040928"/>
    <dbReference type="KEGG" id="tba:TERMP_00610"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.612"/>
    <dbReference type="eggNOG" id="arCOG00959">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_5_3_2"/>
    <dbReference type="OMA" id="CARMCPD"/>
    <dbReference type="OrthoDB" id="124457at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="85" mass="9592" checksum="EC09B60CCB022360" modified="2011-05-03" version="1">MADVEIKTEGYLTIGKTDQVEIDVDTFLCKGCGICVELCPRKVFEWSKELSEKGVHYPVPVHADKCVKCKLCELLCPDFAIAVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKD2</accession>
    <name>F0LKD2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoglutarate oxidoreductase, gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466888.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00613"/>
    <dbReference type="EnsemblBacteria" id="ADT83590">
        <property type="protein sequence ID" value="ADT83590"/>
        <property type="gene ID" value="TERMP_00613"/>
    </dbReference>
    <dbReference type="GeneID" id="10040931"/>
    <dbReference type="KEGG" id="tba:TERMP_00613"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.615"/>
    <dbReference type="eggNOG" id="arCOG01602">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_0_0_2"/>
    <dbReference type="OMA" id="KHSCLTQ"/>
    <dbReference type="OrthoDB" id="76505at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="9"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="170" mass="18182" checksum="48451573334D56DF" modified="2011-05-03" version="1">MQIRLAGIGGQGVVLAGVILGEAAAIEGLNVVQTQDYSSASRGGHSIADVIISKEPIYDLIVTKADVLVALAQLGYDTTKDSLRKDGLLIIDTDLVKPDREFIGAPFTRLAEEKTGLALTVNMVALGYLVAKTGVVKKESVEEAIRRRVPKGTEDINLKAFRVGYEEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKE4</accession>
    <name>F0LKE4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">MTNA-like protein</fullName>
            <shortName evidence="2">aMTNA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466900.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00625"/>
    <dbReference type="EnsemblBacteria" id="ADT83602">
        <property type="protein sequence ID" value="ADT83602"/>
        <property type="gene ID" value="TERMP_00625"/>
    </dbReference>
    <dbReference type="GeneID" id="10040943"/>
    <dbReference type="KEGG" id="tba:TERMP_00625"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.627"/>
    <dbReference type="eggNOG" id="arCOG01123">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_2_2"/>
    <dbReference type="OMA" id="RLWVDET"/>
    <dbReference type="OrthoDB" id="54988at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="353" mass="39462" checksum="7B519AA5798E7846" modified="2011-05-03" version="1">MKLKYKPEELTKLPRSVEYRDKKVYLIDQRLLPREFKVISLSTVEQVAKAIKTMQVRGAPAIGAAAAFGLALYAERSRAETKDEFFNGFYRAYEILKNTRPTAVNLFWALNRIKKLVEEHREDSLAEIKRLIVREAQKIADEDVEANLRMGHIGAEILPEGNVLTHCNAGSLATVHLGTVGAVLRVMHKEGKLNLLWVDETRPVLQGARLSAWEYHYDGIPLKLIADNMAGFVMQQGKVDAIIVGADRIVANGDFANKIGTYTLAVLAKEHGIPFFTVAPLSTIDMSLKSGEEIPIEERSREEVLTCGGCKIAPDVDVYNPAFDITPHKYLTAVITDKGVVYPPFERNLKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKI6</accession>
    <name>F0LKI6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84820">
        <property type="protein sequence ID" value="ADT84820"/>
        <property type="gene ID" value="TERMP_01845"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01845"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1844"/>
    <dbReference type="eggNOG" id="arCOG13984">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178226_0_0_2"/>
    <dbReference type="OMA" id="WIEVYST"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="70" mass="8498" checksum="A8FF96768286E9BD" modified="2011-05-03" version="1">MKRRKLKRIDDEFAEVIIQFFEMLLIEKKFKDEARLLFLMSENRKDWIEVYSTDVRQLVAVKLFSSADLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKL6</accession>
    <name>F0LKL6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468146.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01875"/>
    <dbReference type="EnsemblBacteria" id="ADT84850">
        <property type="protein sequence ID" value="ADT84850"/>
        <property type="gene ID" value="TERMP_01875"/>
    </dbReference>
    <dbReference type="GeneID" id="10042191"/>
    <dbReference type="KEGG" id="tba:TERMP_01875"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1874"/>
    <dbReference type="eggNOG" id="arCOG05407">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1352170_0_0_2"/>
    <dbReference type="OMA" id="FETITMS"/>
    <dbReference type="OrthoDB" id="88290at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="204" mass="23618" checksum="032E6A44F926161D" modified="2011-05-03" version="1">MEEQVIQWLREGRDDAQDIVDLPWNVKKIEEHFYIAEYPKMPFVLNILFSEEFVHLMVPFGLETTALPLEERLKIYHAMLVLNDKINLLKFTLSGINDEIILRVDLDRKTLGKAEFNDALTALLIGINELVRALKVEEDFAQAVFERIVLMLIDRIQRGATRDDLIKFLVVKVGMSKEEAEKFIDEILRSQGISKKKGIDIGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKM3</accession>
    <name>F0LKM3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01882"/>
    <dbReference type="EnsemblBacteria" id="ADT84857">
        <property type="protein sequence ID" value="ADT84857"/>
        <property type="gene ID" value="TERMP_01882"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01882"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1881"/>
    <dbReference type="eggNOG" id="arCOG04225">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_7_0_2"/>
    <dbReference type="OMA" id="HYGKGLP"/>
    <dbReference type="OrthoDB" id="78043at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="193" mass="21901" checksum="9AB636A1653D7225" modified="2011-05-03" version="1">MELRFRNLIFKIAQGDITRFRSEAIVNAANKYLEHGGGVAYAIARAAAGNVREYIRISKEAMREQIGRDWIEHGEVVVTPALRLEQYGIKYVIHTVGPYCGGRWDEDKKEKLKKAILGALRKADELKVRSIAFPAISAGIYGCPLEEVVRTFLETVEKFSGEADNVREVYLVLYSSEDYERALKVLEVEGRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKN1</accession>
    <name>F0LKN1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468161.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01890"/>
    <dbReference type="EnsemblBacteria" id="ADT84865">
        <property type="protein sequence ID" value="ADT84865"/>
        <property type="gene ID" value="TERMP_01890"/>
    </dbReference>
    <dbReference type="GeneID" id="10042206"/>
    <dbReference type="KEGG" id="tba:TERMP_01890"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1889"/>
    <dbReference type="eggNOG" id="arCOG07134">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1954765_0_0_2"/>
    <dbReference type="OMA" id="QWISVKL"/>
    <dbReference type="OrthoDB" id="109646at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036488">
        <property type="entry name" value="DUF1883-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="128" mass="15002" checksum="00D9564911C6C6AF" modified="2011-05-03" version="1">MRRGIVAALAMLIIIGIAVYGLISHYGSYTYQWKTNLNEYKMYHLLGDSILEGYVKANGKISVYIMTRENFEKMKQGEHFEYYKAWEHVKGVEFNNVKIPQGDYILVVKNEENKMQWISVKLREKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKQ2</accession>
    <name>F0LKQ2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Digeranylgeranylglycerophospholipid reductase</fullName>
            <shortName evidence="8">DGGGPL reductase</shortName>
            <ecNumber evidence="8">1.3.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2,3-bis-O-geranylgeranylglyceryl phosphate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Geranylgeranyl reductase</fullName>
            <shortName evidence="8">GGR</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_00654</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2</text>
            <dbReference type="Rhea" id="RHEA:64368"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="ChEBI" id="CHEBI:73125"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2</text>
            <dbReference type="Rhea" id="RHEA:64376"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:138139"/>
            <dbReference type="ChEBI" id="CHEBI:138140"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Reduction reaction proceeds via syn addition of hydrogen for double bonds.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466929.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00654"/>
    <dbReference type="EnsemblBacteria" id="ADT83631">
        <property type="protein sequence ID" value="ADT83631"/>
        <property type="gene ID" value="TERMP_00654"/>
    </dbReference>
    <dbReference type="GeneID" id="10040972"/>
    <dbReference type="KEGG" id="tba:TERMP_00654"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.656"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_0_0_2"/>
    <dbReference type="OMA" id="GMCRREV"/>
    <dbReference type="OrthoDB" id="31233at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045550">
        <property type="term" value="F:geranylgeranyl reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046467">
        <property type="term" value="P:membrane lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01287">
        <property type="entry name" value="DGGGPL_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023590">
        <property type="entry name" value="DGGGPL_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="9">
        <location>
            <begin position="5"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="207"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="286"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="11"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="290"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="397" mass="43995" checksum="8840527D260450EA" modified="2011-05-03" version="1">MELHYDVVVVGAGIAGPILSRNLAKKGYSVLMIDKKAEIGTPKRCGEGLGIEAFKKYDIPLDRRFINREIYGAAIYSPSGYRLEIRYDRVAGVILERKIFDKMLAYYAAKAGADVMAKTEAVGLIRKEGKIAGVKAKHEGEPLEIYADVIVAADGVESRVARWAGINSFLPPHEIDSAYEYEMIIENFEFDPDLIHLYFGNNIAPRGYVWIFPKDEDRANVGIGINGDNPKTAKYYLEKWLKENNIKGTKILEVNVGGVPVGGFLKELVKDNVVVVGDAARQVNPMHGGGMAEAMEAATIASKWIDKALSEENLELLKGYTEEWWAGEGQKLLRILKVRQISEKLSDDELDAAVQALSGADAEKIAAGDYKEVFKALIKHPRILLKPKMLKLLKEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKT8</accession>
    <name>F0LKT8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Archaemetzincin</fullName>
            <ecNumber evidence="1">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">amzA</name>
        <name evidence="2" type="ordered locus">TERMP_00690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable zinc metalloprotease whose natural substrate is unknown.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466965.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00690"/>
    <dbReference type="EnsemblBacteria" id="ADT83667">
        <property type="protein sequence ID" value="ADT83667"/>
        <property type="gene ID" value="TERMP_00690"/>
    </dbReference>
    <dbReference type="GeneID" id="10041008"/>
    <dbReference type="KEGG" id="tba:TERMP_00690"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.691"/>
    <dbReference type="eggNOG" id="arCOG00458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108521_2_0_2"/>
    <dbReference type="OMA" id="RSVYDCD"/>
    <dbReference type="OrthoDB" id="72411at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11375">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01842">
        <property type="entry name" value="Archaemetzincin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012962">
        <property type="entry name" value="Pept_M54_archaemetzincn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012091">
        <property type="entry name" value="Pept_M54_archaemetzncn_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910">
        <property type="entry name" value="PTHR15910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07998">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005785">
        <property type="entry name" value="Zn-prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="185" mass="21103" checksum="D94DE00B027F782B" modified="2011-05-03" version="1">MARLIVVPIVLEKIEKDVVVAVADYVEQFYSRFGLHAVILSEIGIDNFSVEYNWNRRQFLGRTFLPTLAQIKDTLRAGAALGITDADLYEKGLNFIFGLASPYLKVAIISLHRLRPEFYGEINNGELLKNRAIKEAMHELGHVFGLEHCPNPKCVMHFSNSILDTDLKSREYCDNCLKKLKEVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKU3</accession>
    <name>F0LKU3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-methylthioadenosine/S-adenosylhomocysteine deaminase</fullName>
            <shortName evidence="1">MTA/SAH deaminase</shortName>
            <ecNumber evidence="1">3.5.4.28</ecNumber>
            <ecNumber evidence="1">3.5.4.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mtaD</name>
        <name evidence="4" type="ordered locus">TERMP_00695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + H2O + S-adenosyl-L-homocysteine = NH4(+) + S-inosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:20716"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57985"/>
            <dbReference type="EC" id="3.5.4.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + H2O + S-methyl-5'-thioadenosine = NH4(+) + S-methyl-5'-thioinosine</text>
            <dbReference type="Rhea" id="RHEA:25025"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:48595"/>
            <dbReference type="EC" id="3.5.4.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.28" evidence="1"/>
    <dbReference type="EC" id="3.5.4.31" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466970.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00695"/>
    <dbReference type="EnsemblBacteria" id="ADT83672">
        <property type="protein sequence ID" value="ADT83672"/>
        <property type="gene ID" value="TERMP_00695"/>
    </dbReference>
    <dbReference type="GeneID" id="10041013"/>
    <dbReference type="KEGG" id="tba:TERMP_00695"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.696"/>
    <dbReference type="eggNOG" id="arCOG00695">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_1_2"/>
    <dbReference type="OMA" id="FCPVERL"/>
    <dbReference type="OrthoDB" id="40873at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090614">
        <property type="term" value="F:5'-methylthioadenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050270">
        <property type="term" value="F:S-adenosylhomocysteine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01281">
        <property type="entry name" value="MTA_SAH_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023512">
        <property type="entry name" value="Deaminase_MtaD/DadD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="46"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="427" mass="48365" checksum="A010B7DF2155900C" modified="2011-05-03" version="1">MGVLIKNGIMPNGKRGTIYIEDNRIEDINGEIRKDDFVINAQDKLILPAFYNTHTHLPMTFLRGIAEDMWLKDWLERVVWPAEKYINREYVYWGAMLGGLELIRSGIAAVADMYFFMDSVAKALELLGLRGVLGTTIFEFPSPDAKTPEEAFKIVERLVKKYKNHELIKPSIAPHSIYSCNLEILQQAKEIADRYGLLIQIHLSETRWEVYEVQKRYGKRPVELLESIGFLDKNLLSAHAVWLTKAEIKTLAKYGVKVSHNPISNLKLASGGVMPYPEMKEYGVLVTLGTDGVASNNSFDMFEEMKVFAISQKNHRWDPTIAKAEEVFKVATENGAKALGFKAGRIEKGYLADLMIIDINRPHLKPFYDPITLAVYSMRAGDVDGLIVNGKPLMLNKEILVVNEEKTIEKAEKKALKLYEKIVGVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKU4</accession>
    <name>F0LKU4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Methionine aminopeptidase</fullName>
            <shortName evidence="6">MAP</shortName>
            <shortName evidence="6">MetAP</shortName>
            <ecNumber evidence="6 7">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">map</name>
        <name evidence="9" type="ordered locus">TERMP_00696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="6 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="6 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="6 7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6 7">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6 7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466971.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00696"/>
    <dbReference type="MEROPS" id="M24.035"/>
    <dbReference type="EnsemblBacteria" id="ADT83673">
        <property type="protein sequence ID" value="ADT83673"/>
        <property type="gene ID" value="TERMP_00696"/>
    </dbReference>
    <dbReference type="GeneID" id="10041014"/>
    <dbReference type="KEGG" id="tba:TERMP_00696"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.697"/>
    <dbReference type="eggNOG" id="arCOG01001">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_7_0_2"/>
    <dbReference type="OMA" id="NEIAAHY"/>
    <dbReference type="OrthoDB" id="82853at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01975">
        <property type="entry name" value="MetAP_2_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028595">
        <property type="entry name" value="MetAP_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="8">
        <location>
            <begin position="7"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="296" mass="33156" checksum="B1D4D5DE0F7F63F2" modified="2011-05-03" version="1">MNEKIEKLIKAGEIAKQVRKEVIKLIKPGVSLYEIAEFVEKRIVELGGKPAFPCNLSLNELAAHYTPYKGDDTVLKEGDYLKVDLGVHIDGYIADTAVTVRVGMKEDDLMRAAREALENAVSVVRAGVKINEIGKVIEETIRGYGFNPIVNLSGHVIQRYKLHSGISIPNIYRPHDTYTLKEGEVLAIEPFATTGAGQVIEVPPALIFMFVRNRPVRMPQARILLNYIKKNFSTLPFAYRWVQDLMPEPQLRLALMQLEKAGAIYSYPILKEIRGGLVSQFEHTVIVEKDGAKVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKV9</accession>
    <name>F0LKV9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-cytosine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466986.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00711"/>
    <dbReference type="REBASE" id="29882">
        <property type="entry name" value="M.TbaMPORF711P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83688">
        <property type="protein sequence ID" value="ADT83688"/>
        <property type="gene ID" value="TERMP_00711"/>
    </dbReference>
    <dbReference type="GeneID" id="10041029"/>
    <dbReference type="KEGG" id="tba:TERMP_00711"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.713"/>
    <dbReference type="eggNOG" id="arCOG04157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006958_2_2_2"/>
    <dbReference type="OMA" id="EPFTGAN"/>
    <dbReference type="OrthoDB" id="58937at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="321" mass="37151" checksum="51C06A9E036DB184" modified="2011-05-03" version="1">MYTIIDLFAGAGGFSRGFKEAGFKILAAIENFAPKADTYKFNFPEVRMYVEDIKRIHTIDVMRDVGVPDVIIGGPPCEPYTAANLKRKENPLDRLYNDPIGQLVLHFIRFVKDFQPKIFVMEEVPQIMEGELKDALKYEFEKAGYDEIYFNVLDAQDYGTAQRRKRVFISNIRIKPKRVRGKLTVWDVIGDLPDPRLPEALEIPNHRYVPLSPRKQRKIMRLRWGMAMQKFGDSQRKFTNWVRLHPYKVAPTVKGGSRFIHPFDDRLLTVREQARLMGYPDYHIFLGGRDVQYDSVGEAVPPTVAKAIAEYVKEKLDEGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKY7</accession>
    <name>F0LKY7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01919"/>
    <dbReference type="EnsemblBacteria" id="ADT84894">
        <property type="protein sequence ID" value="ADT84894"/>
        <property type="gene ID" value="TERMP_01919"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01919"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1918"/>
    <dbReference type="HOGENOM" id="CLU_665021_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="413" mass="47127" checksum="2B4F2F1FBD61349C" modified="2011-05-03" version="1">MKMVWYLILIIGIFCFLLIHIYELKNSEKLGYNSLILQDAFLKGQLEKVLTVNGTLAKYHNSSYVINFTSGRIVVLKFSKNGLRKVVELKPVNRDVQGYKDLLFLTNGTTLEVYNLSKRKRILRIDADKVLLSNIVAYLRIKGSSYNLDYNTLKLEPVENDGIIFRTGRDIISISGGVIFKDGKVVSGYRGNFTKFLVLPNAYMVVSQNENYTDILLWDTRMERISTIYMDRIFWDAKIYNKTLFISAVHLAHNGTFEIVDRINLAIVDLKTLQGSVIEEKCLGFGAYNKRLCTLCIRNDVLRAETLSGRKCSFWDSPNLPILSVLAAGGNGFIFYELRFAYPTGYVGEYRNVYVIGRSLSLSAEEYYAPEPGENLKIPKVFYNDSPILKVASWESYFATVYKDGSVEVWKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL17</accession>
    <name>F0LL17_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468220.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01949"/>
    <dbReference type="EnsemblBacteria" id="ADT84924">
        <property type="protein sequence ID" value="ADT84924"/>
        <property type="gene ID" value="TERMP_01949"/>
    </dbReference>
    <dbReference type="GeneID" id="26137493"/>
    <dbReference type="KEGG" id="tba:TERMP_01949"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1948"/>
    <dbReference type="eggNOG" id="arCOG01953">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_2"/>
    <dbReference type="OMA" id="ATHHVAR"/>
    <dbReference type="OrthoDB" id="79669at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="9"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="375" mass="40475" checksum="0F7DAC00D9CD88F3" modified="2011-05-03" version="1">METLLMIAMMLATAKLLGWIFEKFGQPVVLGQILGGLIIGIFAESNEIIREFANLGVLLLLFLAGLESDLGEFKRVGKPSMFVAGVGVAVAFAFGFLVSLPFVELHEALLYGAIMTPTSVSITVRVLMELRRLRTKEGTTILAAAVVDDVLGILILTIVLSLLREGSVHYDAIIEILIEVAGFLAVFLYLGPVLAEKAFRKISRIDLPESTTTFAVIFLILFAYLAEHLNLASILGAYMVGLTIGQTNYRKQVENPVNTLGYSLFIPLFFVEVGMRIELTYILHAGLFAVIYASAAILSKILGCGFGAYLGGFDLKASLRIGVGMIPRLGVELAMLAIAMASGVVGADALTVAIFMVFVTTIITPPLLKWVYSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL22</accession>
    <name>F0LL22_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ordered locus">TERMP_01955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468225.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01955"/>
    <dbReference type="EnsemblBacteria" id="ADT84929">
        <property type="protein sequence ID" value="ADT84929"/>
        <property type="gene ID" value="TERMP_01955"/>
    </dbReference>
    <dbReference type="GeneID" id="10042270"/>
    <dbReference type="KEGG" id="tba:TERMP_01955"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1953"/>
    <dbReference type="eggNOG" id="arCOG00029">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_2_0_2"/>
    <dbReference type="OMA" id="MKAYQRQ"/>
    <dbReference type="OrthoDB" id="117225at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="36"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="117"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="182" mass="20360" checksum="EA2EAE5C89CBB521" modified="2011-05-03" version="1">MKDELIGMIFREKCIKFGHFILTSGKESNYYIDVKKLITNPKALKLIAKLMKSEAEKRKIEFDKVAGPELGAVPIATALSLETENPLLIVRKKKKEHGTGKQIEGDVKAGDKVLLVEDVTTTGGSVLRAAKILEKEGAKVVGIMVVVDREEGAKENIEKEGYTLIPLIKVRELFEYKEKYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL34</accession>
    <name>F0LL34_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468237.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01967"/>
    <dbReference type="EnsemblBacteria" id="ADT84941">
        <property type="protein sequence ID" value="ADT84941"/>
        <property type="gene ID" value="TERMP_01967"/>
    </dbReference>
    <dbReference type="GeneID" id="10042282"/>
    <dbReference type="KEGG" id="tba:TERMP_01967"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1965"/>
    <dbReference type="eggNOG" id="arCOG04132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543624_0_0_2"/>
    <dbReference type="OMA" id="NKYSHVH"/>
    <dbReference type="OrthoDB" id="36357at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016675">
        <property type="entry name" value="UCP016666"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09910">
        <property type="entry name" value="DUF2139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016666">
        <property type="entry name" value="UCP016666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="491" mass="54911" checksum="C357AED26B68A805" modified="2011-05-03" version="1">MNQLPNYRFPPRYGPEWGSGGIFGLRYHNGVLYFTVAFEAEAHFVKEDSHRIYEFELVGEKPTSGGDTYNAVDVVDEFIYFGGWVHAPAIYEGKGNEKATINFVNKYSHVHEYDTENDSIRLVWKESIHHPTDWAGEVSDIIYNPYTDELLLAREDGHQNLGIYALDRKKGEIKLLNSAPSPKGTIVHDTAFFGIGKNFAKGLEEIHALDMISGRWEKFKLGESIDGERYLHPHLGAMGSAYNRAFAFVRGGLFVGNPLNDEPFEFFRLFDFYTFYAPFRVNALPLDGGLVIAYNAHHDAIYKPRSPGEIRFAKLTNTIVGPSVLVYIAPPMVKIVGSFGARITSMEKANGKLLLGTNTTPNTGALDATPFDTGNKDIVVLDEKILQEKPPAVSFSIPLAYPSMAMQEGAGAFGGIPLDGYKDPRMVIYASKNNELTIYEYDLTLPPIEACSDKFDIKKGKNIIELNSFSGIVSFRLKEEDFKGKVRIELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL37</accession>
    <name>F0LL37_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468240.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01970"/>
    <dbReference type="EnsemblBacteria" id="ADT84944">
        <property type="protein sequence ID" value="ADT84944"/>
        <property type="gene ID" value="TERMP_01970"/>
    </dbReference>
    <dbReference type="GeneID" id="26137514"/>
    <dbReference type="KEGG" id="tba:TERMP_01970"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1968"/>
    <dbReference type="eggNOG" id="arCOG00159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_2"/>
    <dbReference type="OMA" id="FFAQKAF"/>
    <dbReference type="OrthoDB" id="57718at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="280" mass="32054" checksum="5BE0F42188E58AF0" modified="2011-05-03" version="1">MIPRYKIKSYIVSNLIAWLAGVIWLIPFLGVLMASLRPYEEIVNGWWHLHPFTITLKNYIEAFNHPMFPIGVGLKNSLIIAVPSAIVPLIVASLAAYAFARYSFPVKNYLFTFIVFLMALPQQMTVVPLYFLLRNLHLLNTFRGLILVHSAWGLAWITFFMRNYFSMLPTDVEEAAKIDGASDFTIFYRIVLPMALPGLISAAILQFTWVWSDFFLALVFLQNPAKYVATQRLPLLRGQYYVNWGVLTAASILVMIVPLFVYALFQKYYISGMVGWSTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL49</accession>
    <name>F0LL49_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Potassium efflux system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01982"/>
    <dbReference type="EnsemblBacteria" id="ADT84956">
        <property type="protein sequence ID" value="ADT84956"/>
        <property type="gene ID" value="TERMP_01982"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01982"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1979"/>
    <dbReference type="eggNOG" id="arCOG01568">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_1_0_2"/>
    <dbReference type="OMA" id="FMYFDKP"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="352" mass="39240" checksum="E9A0C15213203A19" modified="2011-05-03" version="1">MFNMTEIFLSSPLSEVTPIMLAKAAAVLLSGIIIANLIKRWIVGISRTTKYVWIINEDTGEAIRRLIIIIALIYSLDTIGVLSISIAGTTLSNLISAFLVFYFSYLIAKKSKDYLLIGGAKRGNLPEVQLKAKLFYYSLLTVAFLIALNIAGFTGKLTTIIAAAGITGIILGFSAQTVIANFISGIFMYFDKPLKIGDPVEVAGYSGVVNDIRILSTRIRTWDGVLVRIPNEKVFNSEIKNLQKFPARRVDVIIGIAYKEDVSRAIEVIKKTLEEMPLVLAEPEPAVYVDELADSSVNIYVKAWAPSEKWFDVRSTILEKLKKALEREGIEIPFPQRVNWFAEELRVKVEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL51</accession>
    <name>F0LL51_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468254.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01984"/>
    <dbReference type="EnsemblBacteria" id="ADT84958">
        <property type="protein sequence ID" value="ADT84958"/>
        <property type="gene ID" value="TERMP_01984"/>
    </dbReference>
    <dbReference type="GeneID" id="10042299"/>
    <dbReference type="KEGG" id="tba:TERMP_01984"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1981"/>
    <dbReference type="eggNOG" id="arCOG05755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_442570_0_0_2"/>
    <dbReference type="OMA" id="WDASEPI"/>
    <dbReference type="OrthoDB" id="12005at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="617" mass="68138" checksum="22835FC90EA8A58C" modified="2011-05-03" version="1">MKKSLLLVLFVAGLVLISGCIGGVKEKAVEEAKEKAESMIESHTMTQTHTESQGESESSYATWTTPWDAYNPISIGSEGYHITYIKYTFMVKTPEGERSYEVIKQRGYVKAHIYSDDNGKKDLGEYNLFAYYGKITPLNDPDMKGSLEYLILIKERTKDSDSYFLTPFPDFGAMMSGTTAVIEASYGGNYFYWSNPASIGKYSELPYTEGDLNTLMGAIPGTAFQGWTVMVSSAVWRGLEDHDLSKPDEYSFSFMGMGYSYKVSPDGTVTFDGKSFMVSNVEWSWAIGNVRGQGKARIAPALPVPVESEGTFSQMGGESYYSKISVEEMKFSKEFEGINVGIEHTTSPGESTGTDTQTGTQTETSTPKLSDNWKLGWDASKSISINGKEYLVKEVTFNVDYKLSGGEEKHFVITKGYREEELNGRSVYLLYAKVEISGESYEYRVYVEPGYLDEYTSGTLWIPSVYDLINGPDFVKVEITGPSCHYSIDEEGNIEGDMSCGMISEDFQKYNMVWSYPTGFYGGIYGDVLTYVTLTENGNGYTVEAGDSVAIGGMTFDTYKVTWNGLVQGGFAQGNGETVVAPELPFPVEVEASLTIPGAGGLYVHARLVDLKLEPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL52</accession>
    <name>F0LL52_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468255.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01985"/>
    <dbReference type="EnsemblBacteria" id="ADT84959">
        <property type="protein sequence ID" value="ADT84959"/>
        <property type="gene ID" value="TERMP_01985"/>
    </dbReference>
    <dbReference type="GeneID" id="10042300"/>
    <dbReference type="KEGG" id="tba:TERMP_01985"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1982"/>
    <dbReference type="eggNOG" id="arCOG04230">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068640_0_0_2"/>
    <dbReference type="OMA" id="LHAILCH"/>
    <dbReference type="OrthoDB" id="51434at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039967">
        <property type="entry name" value="MJ1020-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40517">
        <property type="entry name" value="PTHR40517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="48"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="256" mass="29593" checksum="203DE336CE602496" modified="2011-05-03" version="1">MYEKIKLLSEIKELMENDKLFEMFKKTFEDYEYYFNTTNYIVLNVYQFNDHGSIHVLLTARRALEILKIIKKFGIQTTAEKLGKPFKWSKFIVAFGALFHDIGNMIHRENHYLFSTILAEPIIEKLAKEFEEDDWLLLKALTLNAIYTHDEATQCTTIEGSCVTVADGCDMEQGRSRLVHKKDKVDIHSVSALAIEKVEIQEGDNKTPVVIDVKMRHLSGIFQVDEILTKKIRNSLLSGKVKIRIHAENQVLEKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL65</accession>
    <name>F0LL65_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Folate biosynthesis PTPS-III-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467014.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00739"/>
    <dbReference type="EnsemblBacteria" id="ADT83716">
        <property type="protein sequence ID" value="ADT83716"/>
        <property type="gene ID" value="TERMP_00739"/>
    </dbReference>
    <dbReference type="GeneID" id="10041057"/>
    <dbReference type="KEGG" id="tba:TERMP_00739"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.741"/>
    <dbReference type="eggNOG" id="arCOG02172">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111016_6_3_2"/>
    <dbReference type="OMA" id="KCEKLHG"/>
    <dbReference type="OrthoDB" id="104644at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006113">
        <property type="entry name" value="PTP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="115" mass="13470" checksum="2C514953DC94F6E3" modified="2011-05-03" version="1">MKARIRERFKFDAAHAVVINGEPEEIHGHTFRLEVVVEGELREGYIIDFLELRKIVESVIANLRHKNLNKFFENPTTENIALWIAQKVEEKLPPTIKLQKIVLWEGDENGVEFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLC3</accession>
    <name>F0LLC3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467072.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00797"/>
    <dbReference type="EnsemblBacteria" id="ADT83774">
        <property type="protein sequence ID" value="ADT83774"/>
        <property type="gene ID" value="TERMP_00797"/>
    </dbReference>
    <dbReference type="GeneID" id="26136250"/>
    <dbReference type="KEGG" id="tba:TERMP_00797"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.799"/>
    <dbReference type="eggNOG" id="arCOG05860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122702_0_0_2"/>
    <dbReference type="OMA" id="HHYYYIV"/>
    <dbReference type="OrthoDB" id="107742at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="104" mass="11957" checksum="975B03C3FD54FC05" modified="2011-05-03" version="1">MPKRVKFGHHYYYIVLPDELRDNKFRGKNVVLEGIVEDKPLIEFLPMELPSYRTTFRINGLKIEFSGTPHIGIGEQVKVYGRFVGDGIIAKAIETEKALYVSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLF5</accession>
    <name>F0LLF5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468280.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02010"/>
    <dbReference type="EnsemblBacteria" id="ADT84984">
        <property type="protein sequence ID" value="ADT84984"/>
        <property type="gene ID" value="TERMP_02010"/>
    </dbReference>
    <dbReference type="GeneID" id="10042325"/>
    <dbReference type="KEGG" id="tba:TERMP_02010"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2007"/>
    <dbReference type="eggNOG" id="arCOG04312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107892_1_0_2"/>
    <dbReference type="OMA" id="DEMIINY"/>
    <dbReference type="OrthoDB" id="118267at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041120">
        <property type="entry name" value="PIN_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18477">
        <property type="entry name" value="PIN_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="136" mass="15536" checksum="CA6D2EC1EC9C9B8C" modified="2011-05-03" version="1">MRKAWLVVPDTNFLLIPGQFGVDIIGELNRILDVKFEIVVPNIVLDELNVIEGKAKGKDLMAVRMAKKLAERFKVVEIGKFGEKPTDEQIFEFAVKNSNIVVCTNDKLLKKKLRERGIPVVYLRQKKILELEGMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLI6</accession>
    <name>F0LLI6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_02041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468311.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02041"/>
    <dbReference type="EnsemblBacteria" id="ADT85015">
        <property type="protein sequence ID" value="ADT85015"/>
        <property type="gene ID" value="TERMP_02041"/>
    </dbReference>
    <dbReference type="GeneID" id="10042356"/>
    <dbReference type="KEGG" id="tba:TERMP_02041"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2038"/>
    <dbReference type="eggNOG" id="arCOG02841">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_2"/>
    <dbReference type="OMA" id="VYQEIYY"/>
    <dbReference type="OrthoDB" id="7900at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="24"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="317"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="361"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT85015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="557" mass="63204" checksum="070958CD4E38D351" modified="2011-05-03" version="1">MSANIRDVLEESIKVSKNLKGDIALTIILFFVLSIFGYVQAMLMKNFIDSLVSLREFSTILKIGLALLVLAFLSYIGSFYGEFMLQRLGIKVLKIFSQDLVFSIHRAKLGKISGGDVIARFVSDLPELSLGLAGLIPGLSVQLINIAVATFTLYSLSPTMLLVAILIIPVNYTIYKKASKKSVEYSKRERESLSKVVTVTKTSIDNLFFIKRLDKYEYFEERFSMSLSEWLKNMTRFLRVRIFFQKSYYYTSNIARLVILLVGGWLATKGLISVGAIVAFTNYLPQFYEPLTNLANSFTYLNALIPYVERYKEIVNIEKEDLDKGHELKSIKSIECKNVSVGILSNVTLELKKNETIGIVGPIGSGKTTLALTLVRLYEPESGYILINGKDYRVYSLRSLRRRIYYLPSKDLIFDGTLKENLILGEEYQEDEVIHVLKIVGIDFAELDDYINSKALSEGQRQKIALARALLRKPDILILDEATNSLDVQNEAQVLKKIREFLKDSTLIIISHRLTALKNADKIFVLDRGKIIDSGKHDELYERCSLYRGLVEKSRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLJ8</accession>
    <name>F0LLJ8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA wyosine derivatives biosynthesis protein Taw3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">taw3</name>
        <name evidence="7" type="ordered locus">TERMP_02053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TYW3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468323.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02053"/>
    <dbReference type="EnsemblBacteria" id="ADT85027">
        <property type="protein sequence ID" value="ADT85027"/>
        <property type="gene ID" value="TERMP_02053"/>
    </dbReference>
    <dbReference type="GeneID" id="10042368"/>
    <dbReference type="KEGG" id="tba:TERMP_02053"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2050"/>
    <dbReference type="eggNOG" id="arCOG04156">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047426_2_0_2"/>
    <dbReference type="OMA" id="GKWHHYA"/>
    <dbReference type="OrthoDB" id="118297at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00266">
        <property type="entry name" value="TYW3_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022908">
        <property type="entry name" value="Taw3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSF111278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TYW3" evidence="6">
        <location>
            <begin position="11"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT85027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="196" mass="22373" checksum="BF34C5DF2CC92B9E" modified="2011-05-03" version="1">MFLYEKNFELQKRKAMESLSEALDKGLVDEDIIPLLEKINSLPNYFTTSSCSGRIAVMQMPEFGDKVNAEWLGKWHREVSPEEVLTAVKKHNSGMLWFMLHSPIIHVSAKTLEDAVELLNLAVNCGFKHSNIKSISHKKLVVEIRSTERMDVPLGENGALWVSEEYIAKIVNLANAQLRRAKEKLRKLEGEIEIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLJ9</accession>
    <name>F0LLJ9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468324.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02054"/>
    <dbReference type="EnsemblBacteria" id="ADT85028">
        <property type="protein sequence ID" value="ADT85028"/>
        <property type="gene ID" value="TERMP_02054"/>
    </dbReference>
    <dbReference type="GeneID" id="10042369"/>
    <dbReference type="KEGG" id="tba:TERMP_02054"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2051"/>
    <dbReference type="eggNOG" id="arCOG00792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_8_2_2"/>
    <dbReference type="OMA" id="YANDITF"/>
    <dbReference type="OrthoDB" id="9523at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004483">
        <property type="entry name" value="SMUBP-2/Hcs1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00376">
        <property type="entry name" value="TIGR00376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_11" evidence="1">
        <location>
            <begin position="170"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_12" evidence="2">
        <location>
            <begin position="425"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="652" mass="74459" checksum="C9BD492656CEECFB" modified="2011-05-03" version="1">MNIVRYINHLKELVELEREAEIEAMREEMRKLTGYEREKVGRAVLGLNGKIIGEEFGYKLVKYGRKQEIKTEISVGDLVVISRGNPLASDLIGTVTEKGKRFLVVALETVPSWALRNVRIDLYANDVTFKRQMENLERLSKSGKQALRFALGLEKPKESVEVEFKPFDKQLNESQRKAVSFALGGEDFFLIHGPFGTGKTRTLAEVILQEVKRGKKVLATAESNVAVDNLVERLWGKVKLVRLGHPSRVSKHLKESTLAYQVETHEKFRRVKELRSKAERLAMLRDQCTKPTPQWRRGLTDRQILRLAERGIGARGIPARVVKSMAQWIAFNEKVQKLYDEAKKLEEEIIREVISKADVVLSTNSSAALDFIKDINFDVAVVDEASQATIPSVLIPIAKAKKFILAGDHKQLPPTILSEEAKELSETLFEKLIKLYPSKAKMLEIQYRMNERLMEFPSREFYNGRIKAYDGVKNITLLDLGIRVFHFGEPWDSILNPKEPLVFVDTSKHPEKWERQRKGSLSRENPLEAKLVKEIVKRLLRMGIRPESIGVITPYDDQRDLISSLIENDEIEVKTVDGYQGREKEVIILSFVRSNKKGELGFLTDLRRLNVSLTRAKRKLIAIGDSETLGAHPTYKRFVEFVKKKGAFIPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLQ0</accession>
    <name>F0LLQ0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467125.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00850"/>
    <dbReference type="EnsemblBacteria" id="ADT83827">
        <property type="protein sequence ID" value="ADT83827"/>
        <property type="gene ID" value="TERMP_00850"/>
    </dbReference>
    <dbReference type="GeneID" id="10041168"/>
    <dbReference type="KEGG" id="tba:TERMP_00850"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.853"/>
    <dbReference type="eggNOG" id="arCOG04883">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087835_0_0_2"/>
    <dbReference type="OMA" id="YIATGTT"/>
    <dbReference type="OrthoDB" id="73943at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="271" mass="29037" checksum="D01142CF1F41DF75" modified="2011-05-03" version="1">MMRALVTLTPPESKRLIAKAVVALDEVQYALKHGFVYIATGTTAAYIAEEILGKKIEKEKWTVGVISKGRTCVTPKKTWPKHLVLYKGKPFEGDPVEALKEMGPEDVFIKGANAIDPNWNVAVFAAAPDGGTIGRTFGWTITKGVLTITPISLEKFVPTPVEYSAKITGIHSFDWGTGLYSALVPIPHAVPVTEVEAYDILANVDAIPIAAGGAGGAEGSVTLVLEGDDEDMKKAKEITKQIKGEPYLKPYTENCENCPFAKICGIGSGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLU5</accession>
    <name>F0LLU5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468340.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02070"/>
    <dbReference type="EnsemblBacteria" id="ADT85044">
        <property type="protein sequence ID" value="ADT85044"/>
        <property type="gene ID" value="TERMP_02070"/>
    </dbReference>
    <dbReference type="GeneID" id="10042385"/>
    <dbReference type="KEGG" id="tba:TERMP_02070"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2067"/>
    <dbReference type="eggNOG" id="arCOG03167">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041527_0_0_2"/>
    <dbReference type="OMA" id="QVSYLME"/>
    <dbReference type="OrthoDB" id="21850at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="44"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="254"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="443" mass="51152" checksum="A23D482F2CE6F408" modified="2011-05-03" version="1">MLRDEEILEALVPYNFWGKPQETGIEREEYLEKIETFCRAGNFIIAIIGPRRAGKTFLARQFLKRKISQGLNPKQTLYVNLEDPKFHAYLSLELLDEIYKIYKVYINDEDFSLIVLDEVQNLPNWERWVRSIAEKENAKVIVTGSTSSLLKTEVSGVLTGRSLTLEVFPLTFREFLSFRGLNLRSFAEIVANKIKIERLLAEYMEFGGFPQVVMVEDEYLKREILKELFEGIVIRDVAFRYGFKELNTVKLIAELAVNRFASLVSGSSLRNEVAGIVKRKVSPNFVIEVLNALEESYLIFRIPPLSYKVSDIKRHPRKLYVVDTGIINAVALRFSKNIGRLAGNIVALHLIKKFGKENVFYYKGNREVDFLIKEGLEVTKAIQVSWDLSESKKREVKGLVEAMEEFSLKEGTIVTSAYEGLEEIKEKRIRYIPLWKFLLLGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLV2</accession>
    <name>F0LLV2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02077"/>
    <dbReference type="EnsemblBacteria" id="ADT85051">
        <property type="protein sequence ID" value="ADT85051"/>
        <property type="gene ID" value="TERMP_02077"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02077"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2074"/>
    <dbReference type="eggNOG" id="arCOG02209">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3113261_0_0_2"/>
    <dbReference type="OMA" id="QNVPPRF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="50" mass="5506" checksum="4D259F1575797FAC" modified="2011-05-03" version="1">MQKIARGAGIVFAGTVISMFFGFLSRAVIARYFSTAEYGVFNLALTVWII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLY4</accession>
    <name>F0LLY4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468379.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02109"/>
    <dbReference type="EnsemblBacteria" id="ADT85083">
        <property type="protein sequence ID" value="ADT85083"/>
        <property type="gene ID" value="TERMP_02109"/>
    </dbReference>
    <dbReference type="GeneID" id="10042424"/>
    <dbReference type="KEGG" id="tba:TERMP_02109"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2106"/>
    <dbReference type="eggNOG" id="arCOG07235">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175270_3_1_2"/>
    <dbReference type="OMA" id="WKRISTI"/>
    <dbReference type="OrthoDB" id="126705at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="93" mass="11193" checksum="B07EF5523B25C052" modified="2011-05-03" version="1">MPNITLSIPPEIYEKMKKHKEIKWSEVARKAIIEYLEKVEKGGLEIPSEELLKMLGNDFRKRIKETPVEKYEEYYEKSRGAEWKRLKSFTTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLY8</accession>
    <name>F0LLY8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468383.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02113"/>
    <dbReference type="EnsemblBacteria" id="ADT85087">
        <property type="protein sequence ID" value="ADT85087"/>
        <property type="gene ID" value="TERMP_02113"/>
    </dbReference>
    <dbReference type="GeneID" id="10042428"/>
    <dbReference type="KEGG" id="tba:TERMP_02113"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2110"/>
    <dbReference type="eggNOG" id="arCOG00434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_2_2"/>
    <dbReference type="OMA" id="SRAWAWL"/>
    <dbReference type="OrthoDB" id="49734at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="34"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="309" mass="34812" checksum="3A0C0CED8E9FC406" modified="2011-05-03" version="1">MNGKEFLEKLKEEIHNAVVGKDDVIELLSVALLAEGHVILEGIPGVAKTTIAKSFANALGLKFSRIQLTPDLLPADILGTVYYDQRDGKFKIKKGPIFANIILADEINRAQPKTQSALLEAMQEKQVTIEGRTFPLEDPFLVIATKNPLEFEGVYNLPEAQIDRFMLHIKVGYPDKEEELTLLIRKDKGDFREVKQIFTRGQILTLINQAKKVKTSEDVLHYLYEIISKTRKDERLLIGASPRAAEHLLYASKALAFLRGRDYVIPDDIKEVAVSVLAHRLIVRAEYEIEGVKSEDIVREILDSVEVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM27</accession>
    <name>F0LM27_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467172.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00898"/>
    <dbReference type="EnsemblBacteria" id="ADT83874">
        <property type="protein sequence ID" value="ADT83874"/>
        <property type="gene ID" value="TERMP_00898"/>
    </dbReference>
    <dbReference type="GeneID" id="10041215"/>
    <dbReference type="KEGG" id="tba:TERMP_00898"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.899"/>
    <dbReference type="eggNOG" id="arCOG01354">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2490630_0_0_2"/>
    <dbReference type="OMA" id="LVFSIKI"/>
    <dbReference type="OrthoDB" id="113558at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="81" mass="9271" checksum="1B0A808986E0DAA3" modified="2011-05-03" version="1">MEIKANAEIIWQYNDERTAEAIARAIDVDNLNLPKNLKVKTYWEDCKVITKVKYSGEIESLIVALDDLVFSIKIAEDSLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM45</accession>
    <name>F0LM45_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA double-strand break repair Rad50 ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rad50</name>
        <name evidence="11" type="ordered locus">TERMP_00916</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per homodimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00916"/>
    <dbReference type="EnsemblBacteria" id="ADT83892">
        <property type="protein sequence ID" value="ADT83892"/>
        <property type="gene ID" value="TERMP_00916"/>
    </dbReference>
    <dbReference type="GeneID" id="10041233"/>
    <dbReference type="KEGG" id="tba:TERMP_00916"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.917"/>
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        <property type="taxonomic scope" value="Archaea"/>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR022982">
        <property type="entry name" value="Rad50_ATPase_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rad50_zn_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="10">
        <location>
            <begin position="395"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="181"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="606"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    </feature>
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        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="443"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        <location>
            <begin position="790"/>
            <end position="795"/>
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="883" mass="103724" checksum="3F202FA846FBB2CB" modified="2011-05-03" version="1">MRIEKIIVRDFRSHEFTKVTFTSGINLIIGQNGSGKSSLLDAILIGLYWPAKPKDLKKDSFLRVNGKSTEITIFFEKDGVRYQVHRNITRGIAFAKYYDGTWHYVTDANQKAVRDWMEKLIPYDIFVNAIYIRQGEIDAILESDESREKVVRKVLGLDKYENAYKNLLEVRKVIDSKIKGIEEYLNAMKNIDDMIKEAEKELSSAIRQINELSPQIPRLRREVEELEKKLDELDKLARELEKLKESKSGIEKSLEGINAKINSLAASIAERELKVKELDEKVKELEKIKPKAERYKELEEFYKEYSEIKAKAEKEVERYEGQISQIKERLEELEGRAEELEELQEKISKLDEQLGELEEYVKQYDEALRIKKTIESLRKRLSLSGEELKKLKAEIENAKQRKEEILREIEEIGEKKGELKNATSEKNKAILELRKAKGKCPVCGAELTEKHREDLIKKYTLEIESYAKEMEQLMRREKELRAELVKIEKILKKEKEVIANEEIFNQMQEHEKRLSKFNLKELEEKVKKHENLSAEKNKLEGRLRSIQEELKKKAALEKKKIYLERKISEIKANLYEYEVKLKNLGFEDIDTLKAEIGMLKPIYEKYLKLLNSQKELKAEKERLQRDKNELEILKEKKAGLEKALSEIKERLGELEKDYSKDEHERVRKEHIKKREALVKAETELENLEKRKEELIKNLENLKNEKENVKIKRKELEDLKKARERVQKLREKVRMFKNILKEDALAKVGEYASEIFEELTEEKYSGITVKAKESKVVLGVIYDGKERDLSFLSGGERIALGLAFRLALSLYLAGEIPLLIMDEPTPYLDDERRRRLVDIMERYLRKIPQVIIVSHDEELKDAADRVIRVRLENGVSRVEEVEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM56</accession>
    <name>F0LM56_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00927</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
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            <end position="28"/>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="121" mass="13452" checksum="2B75E97DD8A35B54" modified="2011-05-03" version="1">MNKLQKVFLICGIIEVLLGAVAIYSAYINTRVNPEDFDEAGGTWGQMIVFLGALTLFSIPAYDSKFVVFVILGTARLIGGMFFYLIIQELLKEGIPYTPFVAHALLFFLAMYGILLSFKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
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        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="150"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="397" mass="44697" checksum="1B25AB0B35B3FA2B" modified="2011-05-03" version="1">MIEVLKLLITFAFVIALIRLKIHVGVSIFAGSILLGILFGLTPLEFTKAFYHSSTSWSTVRLILIIVFIMAMTNVFSQIGYLKDMEKAIKELFPKAKYSLAMLPALIGLMPMPAGALVSAPMIEEVANKLSLKPEEKTLVNYWFRHVWEFSWPMYQAIIIASAILGITVREFSTKMFPLTILMILIGYFLILRPIKDESTKEGKKNEGAKLLLKTTYPILVIILISIVLGYDMVYGAFIGLMSALMPHFNKLNKKEIIKHAFQPKIIFLLLAVMYFKYLLQITNAVEALPKAILELNLPVVFVIILTPFIVGLMTGISFAYVGMAFPLLLPFFTGFDKIALAYLSGYMGMLFSPVHLCLVFSAEYYKAELRNVYRKLLVPGTILFTVGVLYTLLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMA7</accession>
    <name>F0LMA7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_02156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468426.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02156"/>
    <dbReference type="EnsemblBacteria" id="ADT85130">
        <property type="protein sequence ID" value="ADT85130"/>
        <property type="gene ID" value="TERMP_02156"/>
    </dbReference>
    <dbReference type="GeneID" id="10042471"/>
    <dbReference type="KEGG" id="tba:TERMP_02156"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2152"/>
    <dbReference type="eggNOG" id="arCOG00932">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053467_0_0_2"/>
    <dbReference type="OMA" id="DCFYCPL"/>
    <dbReference type="OrthoDB" id="85003at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040087">
        <property type="entry name" value="MJ0021-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43288:SF1">
        <property type="entry name" value="PTHR43288:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01108">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="20"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT85130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="360" mass="41239" checksum="BA13E6DF9439FCB4" modified="2011-05-03" version="1">MRESGYYSYVVGELPEGCKLCVKGAKLVLFTTGVCPRDCFYCPLSPWRREDVAYANERPIKSIDDIIEEAKIQEALGAGVTGGDPLARLDRTVEYIKVLKENFGEKFHIHLYTTGALATKENLEKLYDAGLDEIRFHPDLFNPNSKLFKVEIENMKNAFDFDWDVGGEVPAVPGHGEKIKWFAELLDKLGAKFLNINELEFSETNLRALINRGYQPISDESSAIKGSLELGLEILRWGEENTSLRYHLCTAKLKDAVQLKNRLKRMARNVAKPYMEITEDGTLKFAVAEYEDLDELYHLLVEEAEIPEEWLYLNREKGRIEMPIEVALELADAIEGDVKFYIVEEYPTWDRIEVERTPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMC2</accession>
    <name>F0LMC2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02171"/>
    <dbReference type="EnsemblBacteria" id="ADT85145">
        <property type="protein sequence ID" value="ADT85145"/>
        <property type="gene ID" value="TERMP_02171"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02171"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2166"/>
    <dbReference type="eggNOG" id="arCOG05781">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2204242_0_0_2"/>
    <dbReference type="OMA" id="FFWLYFT"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="107" mass="11921" checksum="BF2A3B3E18EA7304" modified="2011-05-03" version="1">MRVESKVSLVIYAMGALGGIISGVLSANANLGYIAGLLLYLLTPKVIKATIKDLPGELQDDNVLLRKSFWGFLLFWFYFTILVYNIVLPQQPVFYSNQSLLYNATKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMC7</accession>
    <name>F0LMC7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468446.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02176"/>
    <dbReference type="EnsemblBacteria" id="ADT85150">
        <property type="protein sequence ID" value="ADT85150"/>
        <property type="gene ID" value="TERMP_02176"/>
    </dbReference>
    <dbReference type="GeneID" id="10042491"/>
    <dbReference type="KEGG" id="tba:TERMP_02176"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2171"/>
    <dbReference type="eggNOG" id="arCOG05723">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_779923_0_0_2"/>
    <dbReference type="OMA" id="EREHETF"/>
    <dbReference type="OrthoDB" id="38332at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002760">
        <property type="entry name" value="O_anti_polymase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01901">
        <property type="entry name" value="O_anti_polymase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="341" mass="39093" checksum="3BD0919463028BD2" modified="2011-05-03" version="1">MKSLKLFSLAFFSYLLLMLCSHLVLKEYSASRSMLPLSLAVILIFYACFVVGYFRPPYLPSEAVWIVIFLLAVYFAQYVVLAPVGVVFLYLLLKYEPEFFRKFSWFVFLLGVGVIASIYLYAGIPFFEYQIRFRLTEVLTLSAYLLLTAIAFEQKERLRFLYFFVSSILLFMSTFRSLLVLMFLAYVIPYYLSGRIKMREILLGILVGMAVLILSGNLERFLVRVGFTFLIFENLVKISLPFGFYHGSLLLSYSPGRKIAFMFTLNRNIYSSFIFGQAVADFGIFGVIEAYLLGAILKYSERDISSLTVVLSLLIYLIEVGIDAFVLAILLFFGINLCPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LME7</accession>
    <name>F0LME7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NiFe hydrogenase metallocenter assembly HypD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468466.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02196"/>
    <dbReference type="EnsemblBacteria" id="ADT85170">
        <property type="protein sequence ID" value="ADT85170"/>
        <property type="gene ID" value="TERMP_02196"/>
    </dbReference>
    <dbReference type="GeneID" id="10042511"/>
    <dbReference type="KEGG" id="tba:TERMP_02196"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2191"/>
    <dbReference type="eggNOG" id="arCOG04428">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048562_1_0_2"/>
    <dbReference type="OMA" id="HVCGSHE"/>
    <dbReference type="OrthoDB" id="24633at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11750">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002780">
        <property type="entry name" value="Hyd_form_HypD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042243">
        <property type="entry name" value="HypD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042244">
        <property type="entry name" value="HypD_2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30149">
        <property type="entry name" value="PTHR30149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01924">
        <property type="entry name" value="HypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005622">
        <property type="entry name" value="Hydrgn_mat_hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00075">
        <property type="entry name" value="hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="370" mass="41495" checksum="3B7C9F769D1AA684" modified="2011-05-03" version="1">MEAFSVFRDKELAQKITRLIHKEAGKIGRVVKIMHVCGTHEDTVTRSGIRSLLPENVKIVSGPGCPVCITPVEDIVRMQEIMRKAYEEGERIILTTFGDMYKIPTPRGSFADLRSEGYDVRIVYSIYDAYKIAKNNPDRLVVHFSPGFETTTAPAAGMLNAVVEENVENFKIYSVHRLTPPAVEVLVRQGTAFDGLIDPGHVSTIIGVKGWEYITTEYGIPQVIAGFEPVDVLMGILMLLRMIRKGEVKIENEYTRVVKYDGNVEAQKLINKFFEVVDAKWRALGVIPKSGLELKNEYRNLEIRSYYDAEVPKLPDLEKGCLCGVILRGLALPPDCPHFGKTCTPRNPVGPCMVSYEGTCHIFYKYGALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMG6</accession>
    <name>F0LMG6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-hydroxybenzoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00969"/>
    <dbReference type="EnsemblBacteria" id="ADT83945">
        <property type="protein sequence ID" value="ADT83945"/>
        <property type="gene ID" value="TERMP_00969"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00969"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.972"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_12_2"/>
    <dbReference type="OMA" id="WYVVVIC"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="427" mass="47443" checksum="F140B1DC5ABA1887" modified="2011-05-03" version="1">MADQNLLPPNYQQIMQEFGISETQMGLVSTIFVATSALITLIWGFLSDIGRRKKLLVIGVLIGEIPCFLTAFVHSYWQLLLMRLFTGIGVGSIIPIGYSLIADMFEEEHRGRGYAYIQTAFGFGTLFGMIIAGLIASWRPPFIIASVPNFILAPLFYLIAEEPKRGGGEKVLKEVLERGYEYTYRLSWDAVKKSFQTKTNLLIFLQGLSGTVPWGVLMYWLVSFLIVTRGMAKDTATFVLLILGIATVIGTLIGGFVGDYFEGKMRGGRAIVTGLAIFLGMLAAIGIIIYPLPSQLSIKGWIVLALYSLLFLQLVSFAGPNVTAIISQVNLPEDRGTVFGVFNIIDNVGKALGPLFGGFLIETLRNAGYSNALAYEYALIIGSLFWIPCALVWLWIRKQYPEDRSRIQEILKKRAEEILRRGNYDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMI3</accession>
    <name>F0LMI3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00986"/>
    <dbReference type="EnsemblBacteria" id="ADT83962">
        <property type="protein sequence ID" value="ADT83962"/>
        <property type="gene ID" value="TERMP_00986"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00986"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.989"/>
    <dbReference type="eggNOG" id="arCOG05756">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_958535_0_0_2"/>
    <dbReference type="OMA" id="FESGDIM"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="289" mass="32130" checksum="697F990BCFB36BC1" modified="2011-05-03" version="1">MGRTLGLFLLFLGALILLKKFYPETLTYLAPYAHYIKASFWGVALICLGLYLLSKNKAWRTTISAIFILYVALYLVVPDVGTTSWYSIGEWFGEKIEEEMHTVGEFQASELIIQDIVAETKIISTDGNSIKVTSNLPIQGEISGDTLILKCTKICSKYKNGKLIVEAGKGLLKSLEISNTVGDYYINLEDNLSQIMIKNTVGRFSISQMRSEELYLSDFVGDFNIEIEECSQITMEDGIGDVTIDVPSEYKVVPIIRDSATKIETNSNESGTKTLKLIVDSVIGRVKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMN0</accession>
    <name>F0LMN0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467307.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01033"/>
    <dbReference type="EnsemblBacteria" id="ADT84009">
        <property type="protein sequence ID" value="ADT84009"/>
        <property type="gene ID" value="TERMP_01033"/>
    </dbReference>
    <dbReference type="GeneID" id="10041350"/>
    <dbReference type="KEGG" id="tba:TERMP_01033"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1036"/>
    <dbReference type="eggNOG" id="arCOG03661">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003442_1_0_2"/>
    <dbReference type="OMA" id="GQYWDAW"/>
    <dbReference type="OrthoDB" id="20900at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="6">
        <location>
            <begin position="526"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1007" mass="117779" checksum="871FC85DF025CF1D" modified="2011-05-03" version="1">MMGLAEIERKAFDLMATSIRKYEFIERWKFEGKTIKLPFQREAEPNTLVVFSREIEVPNDGLKWFLKVSMEGNALVKLDGTAYGTIDDVHTYIPIRPGKHKLELIVSPLSMFGYHKWRIKIDYAMLVGIMWEPYVLAQRLLDLVSFIEVIQEEDLKEALMKELSDILIRVKSVPNIKQITLLRMLLHDGGLGIKELKIGRFDVRDVRPDYMFLSAVYGIGAMKGKIEDIPKPRREHYLKEIDRILEELEDALTRLRRIFPKIGKAYAFAHSHIDAAWLWPYSETKQKILRTFSTIERLMRRYGITYIQSSAQYYEWLEELDKELFEKVKKYVREGKWILAGGMWVESDVQLIDGESLVRQFLYGQRYFLEKFGRIAKIGWLPDTFGFSASLPQIMKKSGIEVFATYKLLWNERNEFPYHAFIWKGIDGTEIPVHIMMSYKSSMTAKSLYKQWKRYKNKYEVPFLLYAYGYGDGGGGITWEMVEMMKHMNKVPHIPRIVKGYEDEYVAELKSCIDNMPTWEGELYVEVHRGTYTTNLKMKKYMADAESVLRSAEIWSSIAEILGLVEYPKEELEKLWKRVLLHQFHDVLPGSSIREVYDEAIADLKKVIREAEEIIHSVLERIAEREGNDLVFNDLPWERREVVEVNGEYYLLEAPPLGWKAFEPIEAKEGVKVREERDKIILENECLRAVINKDGELISLYDKENKREALRSTSNVLMAHIDTPGMWDAWDINEDFLIQGEKLKTLEKAKVVYQSPLIAVIKVVKGYGNSRVTQFIKLRKESKLLEFETKVDWRDKEILLKAWFNFNTHNWSSFYDIPYGVIERPAVRNTPWEQAKFEVPALRWADVCDGDYGVAIICTSRHGYTNWDSKIGLSLLKSPIYPNPWSDLGEGEFTYYIYPHKGDWFEGEVYKRALEVWSKLRVVKAERVKRKAKEFSFMRTDAVVGALKKAEDGNGYILRLYNPSKEEFEVELPREGIEMDMIELKELGNVGRKVKLEPFEIKTIKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMN3</accession>
    <name>F0LMN3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PutP-like proline/sodium symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_01036</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467310.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01036"/>
    <dbReference type="EnsemblBacteria" id="ADT84012">
        <property type="protein sequence ID" value="ADT84012"/>
        <property type="gene ID" value="TERMP_01036"/>
    </dbReference>
    <dbReference type="GeneID" id="10041353"/>
    <dbReference type="KEGG" id="tba:TERMP_01036"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1039"/>
    <dbReference type="eggNOG" id="arCOG01316">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_15_2_2"/>
    <dbReference type="OMA" id="YIAQRMM"/>
    <dbReference type="OrthoDB" id="8968at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005298">
        <property type="term" value="F:proline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031402">
        <property type="term" value="F:sodium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015824">
        <property type="term" value="P:proline transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11475">
        <property type="entry name" value="SLC5sbd_PutP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011851">
        <property type="entry name" value="Na/Pro_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="503" mass="54289" checksum="3F55FD37CD547057" modified="2011-05-03" version="1">MDIVVVSFVIYLVAMIAIGILTYRIGSESIEGYFLGKRRFGPFTIALTHQATAMSGYMFQGMPGKGYSLGFGSVWVPMASAGGPLVNFTILGKRLRRFTEKVGAITIPDFLEARYYDRSHSVRIISVAIIFIFLTAYTAAQTVAMGRTLEFLTGIPYKWGAIIGALTVLIYVLLGGFAAAVYTDVVQAVLMFIGAVVVPGLAIAKIGGFTIMYNKLNAIDPKLTNVWVAPVTLLGFLAIGYLGYLGQPQLHVRFMAIKDSKMLKYSLLAAVVWAVIALYGVTLGGVAARVLIPNIKPELSLMALTKEMLPPVFAGILIAAMAAAIMSSANSYLLVVASALARDIYNKMINPEADQEKLVWISRISVLVVSLLSIYLALGATETVFKLVLYAWAGLACSFGPVVILGLYWKRATKEGAIAGMIVGALTVIAWKQAGLSWHPWYEMIPGFVFSMIAIIVVSLLTKEPPKEIQEIVEYAAGKKVVIKGGAATPELKTLAGIVDELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMT0</accession>
    <name>F0LMT0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467357.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01083"/>
    <dbReference type="EnsemblBacteria" id="ADT84059">
        <property type="protein sequence ID" value="ADT84059"/>
        <property type="gene ID" value="TERMP_01083"/>
    </dbReference>
    <dbReference type="GeneID" id="10041400"/>
    <dbReference type="KEGG" id="tba:TERMP_01083"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1086"/>
    <dbReference type="eggNOG" id="arCOG10088">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091965_0_0_2"/>
    <dbReference type="OMA" id="AGWVTEF"/>
    <dbReference type="OrthoDB" id="61297at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043754">
        <property type="entry name" value="DUF5700"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18958">
        <property type="entry name" value="DUF5700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="264" mass="32009" checksum="5A5173C71188FF51" modified="2011-05-03" version="1">MLIDTFPTFLKHWDGTEESWLRYIQEYPELLEKIKWDYERYKMDWREYLKLLTKRNTDELKLAYENLLKVLPEVESEIRARFDIKDYNIVIYVGLENGAGWVTEFMGKPSILFGLEAIAELKWYDRLKGLIAHEFGHLVHWILRGEDIEKLEDEQIMWLYTEGFAQRIEDLITGRPWEVESEGWFEWCEEHEKLLKEEFLRRVKKGEALNPFFGSWYQLFGKQFLGYYLGYKFILKLEEKFSLEEIAKLEKEKIKGEILKFLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMV5</accession>
    <name>F0LMV5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467382.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01108"/>
    <dbReference type="EnsemblBacteria" id="ADT84084">
        <property type="protein sequence ID" value="ADT84084"/>
        <property type="gene ID" value="TERMP_01108"/>
    </dbReference>
    <dbReference type="GeneID" id="10041425"/>
    <dbReference type="KEGG" id="tba:TERMP_01108"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1111"/>
    <dbReference type="HOGENOM" id="CLU_1682790_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="156" mass="17738" checksum="F1FF88E7AC05600C" modified="2011-05-03" version="1">MEDDEKGLYVFFLIAGILMQLGVASMFYEFDYATNIKLGISVLEFFWPFFEASIVLSILTSLPALISRNKMSIIRAFALTQFLFIPLYFLIIMIDSILFFPRRGSLSLVNFLVGSLAFLFVNYGKIEKKKLTFGVFLSGIVYAALIYFAMFHGIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMX8</accession>
    <name>F0LMX8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative multiple sugar transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01131"/>
    <dbReference type="EnsemblBacteria" id="ADT84107">
        <property type="protein sequence ID" value="ADT84107"/>
        <property type="gene ID" value="TERMP_01131"/>
    </dbReference>
    <dbReference type="GeneID" id="10041448"/>
    <dbReference type="KEGG" id="tba:TERMP_01131"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1134"/>
    <dbReference type="eggNOG" id="arCOG00177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OMA" id="VYYKPKY"/>
    <dbReference type="OrthoDB" id="88924at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
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    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
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    </dbReference>
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        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="360" mass="40835" checksum="316264E1511BCECE" modified="2011-05-03" version="1">MVKITLENITKKFGDFTALDNINLKIDDREFMALLGPSGSGKSTLLYTIAGIYKPTSGRIYFDDRDVTEVPPKDRNVGLVFQNWALYPHMKVFDNIAFPLELRKAPKQEIEKKVIEVAKMLHIENLLDRYPWQLSGGQQQRVAIARALVKEPDVLLLDEPLSNLDALLRIEVRAELKRLQKELGITAVYVTHDQAEALAMADRIAVIREGKILQVGTPDEVYYKPKYKFVGGFLGNPPMNFVEAEVENDYLRVYESRIPVPGQYRGLIEKLGIKEVLLGFRPHDAEVVKGISEGLVGEVYSFEPLGREQIVTVSVDKAFVKVFAPEGEHFTFGEKVTVKIREDRIVLFDKKTEKALEFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMY9</accession>
    <name>F0LMY9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+) H(+) antiporter subunit A Na(+) H(+) antiporter subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467416.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01142"/>
    <dbReference type="EnsemblBacteria" id="ADT84118">
        <property type="protein sequence ID" value="ADT84118"/>
        <property type="gene ID" value="TERMP_01142"/>
    </dbReference>
    <dbReference type="GeneID" id="10041459"/>
    <dbReference type="KEGG" id="tba:TERMP_01142"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1145"/>
    <dbReference type="eggNOG" id="arCOG03079">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069132_2_0_2"/>
    <dbReference type="OMA" id="YETAVFF"/>
    <dbReference type="OrthoDB" id="97304at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MnhB" evidence="7">
        <location>
            <begin position="109"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="256" mass="27959" checksum="055D34D2FA42B5F0" modified="2011-05-03" version="1">MKKLIPLAVILVTIFALAYYIAPKLPQQTELRPLGEFYLENSYFGDYSAKSPEVVTSILWDYRGVDTLFETSVFFLAIIGSLTLFRLNKKQEKEAKQKPKEFNGGLTLVIKSVTKIIVAMILAVSASIALHGHLTPGGGFQGGSALAVAPLLIIAAYSKYALEEHGLDKTRALILRSIGLLGIALIALVPILSGGFIMQNQPVFPAELGGQLVSGSLIYYNFFEFLAVGAGFTAVFLLLAIPESVFRKFLRRVENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN93</accession>
    <name>F0LN93_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Resolvase/invertase-type recombinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
            <plasmid evidence="2 3">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747454.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02259"/>
    <dbReference type="EnsemblBacteria" id="ADT85232">
        <property type="protein sequence ID" value="ADT85232"/>
        <property type="gene ID" value="TERMP_02259"/>
    </dbReference>
    <dbReference type="GeneID" id="10549083"/>
    <dbReference type="KEGG" id="tba:TERMP_02259"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2253"/>
    <dbReference type="eggNOG" id="arCOG03162">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2949485_0_0_2"/>
    <dbReference type="OrthoDB" id="59998at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="59" mass="6786" checksum="AB2938CF28F8B432" modified="2011-05-03" version="1">MRIKAVVYSRVSTEEQNPKAQLEVVLQYAQERGYGVVKIFEEHISGSTDPLERPVFKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LNA3</accession>
    <name>F0LNA3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
            <plasmid evidence="3 4">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747464.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02269"/>
    <dbReference type="EnsemblBacteria" id="ADT85242">
        <property type="protein sequence ID" value="ADT85242"/>
        <property type="gene ID" value="TERMP_02269"/>
    </dbReference>
    <dbReference type="GeneID" id="10549093"/>
    <dbReference type="KEGG" id="tba:TERMP_02269"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2263"/>
    <dbReference type="eggNOG" id="ENOG502N5PX">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1507461_0_0_2"/>
    <dbReference type="OrthoDB" id="131014at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="157" mass="18270" checksum="3EBD9206428202E9" modified="2011-05-03" version="1">MKVRFRLFWIFVFVVSFVSVLLVYGIPTTPISENIDQALAECYQQLLILNKTLENVTKERDYYKSLYENISVNVTNFELIQIRNNINILNQRIEQLSSQVLSLKNSIRLTMRRYFVLGITFGSVFGSVVGTLVSINYYLKKAPEEKKKVKQSDEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LNA4</accession>
    <name>F0LNA4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0310 protein TERMP_02270</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
            <plasmid evidence="3 4">pTBMP1</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0310 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747465.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02270"/>
    <dbReference type="EnsemblBacteria" id="ADT85243">
        <property type="protein sequence ID" value="ADT85243"/>
        <property type="gene ID" value="TERMP_02270"/>
    </dbReference>
    <dbReference type="GeneID" id="10549094"/>
    <dbReference type="KEGG" id="tba:TERMP_02270"/>
    <dbReference type="eggNOG" id="arCOG02727">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148445_0_0_2"/>
    <dbReference type="OMA" id="RHINTIS"/>
    <dbReference type="OrthoDB" id="92589at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00771">
        <property type="entry name" value="UPF0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022996">
        <property type="entry name" value="UPF0310"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="2">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="143" mass="16883" checksum="36BCD79996E780E1" modified="2011-05-03" version="1">MAYWLCITNRDNWEVIKKENVWGVPKRHRNTIAKVKLGDKLVIYVKQERKDKQILEPKIVGIFEVVSEPYQDSTKIFKSPPHLNETYPLRVKIKPVKLGEVEFKPLIPKLKFITNKKKWSGHLMGKAMRELPEEDYKLIESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGW9</accession>
    <name>F0LGW9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosylhomocysteine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467475.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01201"/>
    <dbReference type="EnsemblBacteria" id="ADT84177">
        <property type="protein sequence ID" value="ADT84177"/>
        <property type="gene ID" value="TERMP_01201"/>
    </dbReference>
    <dbReference type="GeneID" id="10041518"/>
    <dbReference type="KEGG" id="tba:TERMP_01201"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1204"/>
    <dbReference type="eggNOG" id="arCOG00695">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_0_2"/>
    <dbReference type="OMA" id="TWLAHGI"/>
    <dbReference type="OrthoDB" id="40873at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="53"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="409" mass="45806" checksum="15F37D4B48044409" modified="2011-05-03" version="1">MKAILAKYILDVNGVREDMAVLIEGNKIYDVIPKDKLKEYDVDETFGGEKYLLIPGLINAHTHVAMTKFRGIGDDLPLDKWLNEVIWPMEKEWSKEEIHKWALIGIAEAIANGSTVINDHYFFADEIAKAAQKLGIRAFVGQTMLDLVEFPIAEPEDGFRFFKRWKDRDELVKPVLAPHATDTVSLDLLKEIKEFSENEKALIHMHVSQSREEVLRVKRREGILPVEYLKKAGVLNESFIGVHGVYLSEKEVGLYAKSGATLVHCAISLAKLEGSIAPIVDLWEKGGNIALGNDCAASNNSLDMIQEMKFAAILNKVRNHDPTKASAKDVFYWATLGGAKALKIKAGLIEKGYLADLVLININKLHFLPETNILSHLVYSAKGSDIEMVFVDGELIYQLGNFTKEQIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGX8</accession>
    <name>F0LGX8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagella protein FlaI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467484.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01210"/>
    <dbReference type="EnsemblBacteria" id="ADT84186">
        <property type="protein sequence ID" value="ADT84186"/>
        <property type="gene ID" value="TERMP_01210"/>
    </dbReference>
    <dbReference type="GeneID" id="10041527"/>
    <dbReference type="KEGG" id="tba:TERMP_01210"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1212"/>
    <dbReference type="eggNOG" id="arCOG01817">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005379_2_2_2"/>
    <dbReference type="OMA" id="CLEYGMS"/>
    <dbReference type="OrthoDB" id="9947at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="1">
        <location>
            <begin position="162"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="541" mass="62027" checksum="87E3EE833F32676C" modified="2011-05-03" version="1">MAEKFSDSLEVAMARNPHLRRYINSFVKQTGKFPEFHVQLSRSMKEIKYPNIIYPVGDPIFIHIYGDPKTERKYIVIEPRITSPQEEEKYELIKDKILEMAPTKRIPEDKEEFEMFLDSLFDEALSKVSKGGLFRRNTVNITREEAEKFRYLLKRDIVGIGPLEPLIRDPYIEDIHIIGANYVSLVHKIFESLPTNITFGDNIRLADYFKNLSERMGRPVSDKNPIVDGTLPDGSRINIIYSPDVSIKGPSATIRKFSATPLSVVQLVNWNTFSAEIAAYLWIALEYGMSIFVCGETASGKTTTLNSIIPFIKPNAKIYTAEDTPEVVVPHPTWQRLTTRERGPEESRVTLFDLLKAALRSRPNYIIVGEIRGAEGAIAFQAMQTGHPVLSTFHAGDIKKMIQRFTGSPINVPVTFIDNLNIAIFQQAVYVRGKFLRRVVSVVEIEGYYEELGGVATRNVFEWDSVSDRHIFRGMNNSYILERKIAEVAGYEDPKDIYNELFLRARIIKRMIELGIMDYYSVYREIKNFYEKGIEGLSFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH17</accession>
    <name>F0LH17_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01249"/>
    <dbReference type="EnsemblBacteria" id="ADT84225">
        <property type="protein sequence ID" value="ADT84225"/>
        <property type="gene ID" value="TERMP_01249"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01249"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1251"/>
    <dbReference type="eggNOG" id="arCOG02559">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_887454_0_0_2"/>
    <dbReference type="OMA" id="WENGWVE"/>
    <dbReference type="OrthoDB" id="49678at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="340" mass="37322" checksum="F404F4D670362089" modified="2011-05-03" version="1">MEEETVPAPGMSTKDCILIIGSVKNENYKIMLIKLNYEEELEWFKFFGGKDDWEGHSIAKVDDGYLIGGAVEGVATPDGGKSWKAYLAKVDGNGNKIWERKYRILGNECVYSIVPLDDGILLGGEVSGGSRRGFFVMKTDLKGDQLWKRTLGAWEDAIFGGIVEGRDGFTLIGSVKDTGWSVVAFELDEKGNTIKDRILGDGIALDVTDLNGKILITGDKNGEFWVSLIGKWETALGEGVGTAIQILSDGILVGGELDGSAIVTKLGFDGKLIWKKEFWENGWVEVVKRAEDRIFVAGVAVVPGYQEKEKTVKESKIQILVDYLARRTVEVVNILRGDMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH19</accession>
    <name>F0LH19_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01251"/>
    <dbReference type="EnsemblBacteria" id="ADT84227">
        <property type="protein sequence ID" value="ADT84227"/>
        <property type="gene ID" value="TERMP_01251"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01251"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1253"/>
    <dbReference type="eggNOG" id="arCOG01324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2271169_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="102" mass="11159" checksum="49857FF0F8B6737F" modified="2011-05-03" version="1">MLVEETGAIREEVQLVMLYCPLIIQGDGNKVRDYSSRGILGVEMEASALMSVASFRGVDLAVALAVSDELYKGKWNPGFGSKKLKRTERLLVKAALETLISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH25</accession>
    <name>F0LH25_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467531.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01257"/>
    <dbReference type="EnsemblBacteria" id="ADT84233">
        <property type="protein sequence ID" value="ADT84233"/>
        <property type="gene ID" value="TERMP_01257"/>
    </dbReference>
    <dbReference type="GeneID" id="10041574"/>
    <dbReference type="KEGG" id="tba:TERMP_01257"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1260"/>
    <dbReference type="eggNOG" id="arCOG00126">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1248335_0_0_2"/>
    <dbReference type="OMA" id="FPEYCLT"/>
    <dbReference type="OrthoDB" id="66517at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="221" mass="25408" checksum="7CB1EC4EA4B70149" modified="2011-05-03" version="1">MRVALIPMNVEAGNFEANWQEFKRRFEEALEHSPDIMVFPEYCLTGFDEWDFSGAKLYDEIVNRVSTLAKENSVYVILGLLEPYKRCVYNSALLFNRGGEVILKHRKFQEPMKFCTGNTVKTAKTEFGKFAIIICGDLYNKRILKWVKLKKPDYIFVPMEYSPDYGKLNEEDVEAMGKRVKLLSTKTFIVNSYPPGGAWVFDEEGKLLTSSKGKEILGVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH74</accession>
    <name>F0LH74_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00058"/>
    <dbReference type="EnsemblBacteria" id="ADT83036">
        <property type="protein sequence ID" value="ADT83036"/>
        <property type="gene ID" value="TERMP_00058"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00058"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.58"/>
    <dbReference type="eggNOG" id="arCOG10097">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573213_0_0_2"/>
    <dbReference type="OMA" id="GGCFAPD"/>
    <dbReference type="OrthoDB" id="72719at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="501" mass="58411" checksum="15A580677D90F9FE" modified="2011-05-03" version="1">MFFALLRNWKSIYSTFGYGISDELVWGGRMRKWVVLGVVVLLVFSSFGFVFAEQFQEVKDLQVKTEKCEGCSCQDFDVDKALSEVNAKIENLTKVINQEEAELQKLYAELNRTKSIETLEKIVKLEDKVQNIKHDLKAFERQKLSLELVKKYTRKTPYGLQVLYYKLPREDVLVKQYIEKVHPVREDVDLDWFIAFYRQAGELTFDEYIETDMKLRETLKAVKAGNATIEDALKLIQQRKEIWDRIYGYLEEKTKLETIKRLKELGKQQTIMKTIGIQPLGIDNIIYYSELGTRYVCSQVSIGGVLYCGGDNPLKDTLPPYYISPVEYRDLEPIAVWVGVYASDTPNSDYYLGQFCVYTFKKESELHYYWERARNYDVRAKSIQIKYFYDGIAYNPKTSEEQVANLIWQFECNANGCWLTSYRPHLPNPDNPYYIPNDNYRLYVYWRVLSSNCCKSGSSHDNPYGCLWANGHCGGCFAPDDSASQYFPHVDRPYQVDIPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH93</accession>
    <name>F0LH93_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sld5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466353.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00077"/>
    <dbReference type="EnsemblBacteria" id="ADT83055">
        <property type="protein sequence ID" value="ADT83055"/>
        <property type="gene ID" value="TERMP_00077"/>
    </dbReference>
    <dbReference type="GeneID" id="26137930"/>
    <dbReference type="KEGG" id="tba:TERMP_00077"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.77"/>
    <dbReference type="eggNOG" id="arCOG00552">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1615392_0_0_2"/>
    <dbReference type="OMA" id="IRNEWLG"/>
    <dbReference type="OrthoDB" id="92854at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld5" evidence="2">
        <location>
            <begin position="29"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="164" mass="19411" checksum="0293FECD0FC5C3EE" modified="2011-05-03" version="1">MFAGRTLIAVKLLKSFGDWKAGDMVLIEDWKAKELWESGIVEIIDEAEKVIGELDRVIAEEKENEPITPIPEGLYERAEFYIYYLENFIKENFEGNVDVLNVKMTRLANLKKKYYYLKKLRFNKILNAIMFRPNSLEVLSRLSPEERRVYLQISKIRNEWLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH94</accession>
    <name>F0LH94_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA replication helicase protein MCM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_00078</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00078"/>
    <dbReference type="EnsemblBacteria" id="ADT83056">
        <property type="protein sequence ID" value="ADT83056"/>
        <property type="gene ID" value="TERMP_00078"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00078"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.78"/>
    <dbReference type="eggNOG" id="arCOG00439">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03151">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03155">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03158">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_2"/>
    <dbReference type="OMA" id="VTPTHPF"/>
    <dbReference type="OrthoDB" id="3067at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="PTHR11630"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="7">
        <location>
            <begin position="279"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="9">
        <location>
            <begin position="613"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="8">
        <location>
            <begin position="902"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="MCM" evidence="7">
        <location>
            <begin position="924"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="9">
        <location>
            <begin position="1071"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="8">
        <location>
            <begin position="1334"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="domain" description="MCM" evidence="7">
        <location>
            <begin position="1349"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1226"/>
            <end position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1624" mass="185930" checksum="611487F3017C2C93" modified="2011-05-03" version="1">MMDKEEMISRFVNFLREYSDDKGSKVYLNKISDILTVTPKRSVSINWEHLNGFDPELAQELLENPEETLLAAEDALQIILQEEFFKKEPLKIHARFYNLPKTLLVKELGSEHINKLIQVEGIITRMSEVKPYVAKAVFVCKDCGNEMIRLQKPFAPLVKPNKCDQCGSKNLELDVDKSNFINLQTFRLQDRPESLKGGQMPRFVDAILLDDLVDTALPGDRVVITGILRVILEQREKRPIFKKILEVNHIEQISKEIEELEITPEDEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVTRQLPDGTKLRGESHVLLVGDPGVAKSQILRYVANLAPRAIYTSGKSSSAAGLTAAAVRDEFTGSWVLEAGVLVLADGGIACLHPDTRVLVDGKYKRIEELFEVENSYKAKSGDEIVDIEEKKLEVVAIDLSKMKTKRAISTVIRRKPWKGELTKIKLRSGNEITLTPDHLLIDGRTLEWKEAGKFKVGDLIVAPLKLPNVREKVYILDILPDEWKVKLTDEEKTELKREVLKRFRSFAEFNRYYGISKDFLSGKGTITVGKFREILKDFGIYEDWKKKPLAVGPHSRRERLKVAYITPELAYFLGFLYGDGWIKRNGSRVQVRIVQSKVHKKQIEAIRNVFHAFYEGDLREYERVTESEVAGNKISSKTITFHISSPLIAYIYEYLTKNALENIFVLDDEAAKAFIAGALDSDGCVSIKKSTKGRVIHVEFLLSNDIESDRAFALLLRRFDVYARIIPDKGVNRIRIAGREDVKNLLIAVRKYSVKVKEIPDMKHLVSSRSDKVPAEPVKQIARKIVERVPSTVLQKKGLWSTLYAYMKGGYLPSRAQLRKILKRLNDFLDEETKFKLNILITRDYFLDEIVSIERIPYDGYVYDLYVLDLHNFVAGGIVVHNCIDEFDKMSDRDRSAIHEALEQQSYHKDFELLLADGRKVKIGEFVDELIERNRDKVIVGKDTEILPVDDVYLLAYDLERMKVIKVKADRVSRHKAPEKFIRLRFSNGREIIVTPEHPIMVWENGKIVEKRADAVEKDDLVVGVKDYPLLGDLEGARDLALSLFTKSYRFKKSARLPPEVFKLKREELEEFLRTIWEIRGSIINGKPCIRFPNRGLAEDIQDILLMLGISSSIYESPTTITLIVHEKESVERLMRITGKAFGVQRSSEIIPGDLARRFLEVSKLLRVWISHKDRVKLYRDYVPRDVLLKYYNNAKAELERLKQVIEKQNYEPLLKIISTYRIYSKYGISPLSLKNLLRKGDKRALEIVLSEAKKVVEHAENILVQIGKILNSNIKFIKVIKVEEVENRDSEWVYDVTVEPYNLFVSHGLILHNTISISKAGITATLNARTTVIAAANPKHGRFNKMKPLPEQLDLPPTLLSRFDLIFVLIDEPNEKLDAEIASHILKVRKGEAEAITPKIPYDLLKKYIAYARKNIHPVLSREAMDEILHYYVKMRKGLKRTTEAEGVKPIPITARQLEALIRLAEAHARMRLSEIVTREDAREAIKLVEYTLRQIAVDEEGVMDISILEVGKSARKINKVDKLLEIIEALQDQSEYGAPIDDIIKEAMRAGIDKKEVRKLIEDLKANSRIYEPRNGYYKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHB1</accession>
    <name>F0LHB1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S19P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps19p</name>
        <name evidence="7" type="ordered locus">TERMP_00095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466371.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00095"/>
    <dbReference type="EnsemblBacteria" id="ADT83073">
        <property type="protein sequence ID" value="ADT83073"/>
        <property type="gene ID" value="TERMP_00095"/>
    </dbReference>
    <dbReference type="GeneID" id="26135411"/>
    <dbReference type="KEGG" id="tba:TERMP_00095"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.96"/>
    <dbReference type="eggNOG" id="arCOG04099">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097347_1_1_2"/>
    <dbReference type="OMA" id="VIRTHCR"/>
    <dbReference type="OrthoDB" id="99236at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_S19A/S15e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="132" mass="15340" checksum="59AEF510FC4B7436" modified="2011-05-03" version="1">MARKEFRYRGYTLEELLNMPLDKVAELFPARQRRSLKRGFSPEQKKLLRKIRLAKKGKYKKPIRTHCRDMVILPEMVGITIYVHNGKEFVPVEIKPEMIGHYLGEFALTRKRVQHGSPGVGATRSSMFVAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHE8</accession>
    <name>F0LHE8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01300"/>
    <dbReference type="EnsemblBacteria" id="ADT84275">
        <property type="protein sequence ID" value="ADT84275"/>
        <property type="gene ID" value="TERMP_01300"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01300"/>
    <dbReference type="HOGENOM" id="CLU_3039245_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="54" mass="6326" checksum="CF9FEA52D12CFBCB" modified="2011-05-03" version="1">MNALYVCKEKSGLFFKYIKVSLRTSMYRKSEESANIKSAGQRVKYIKPHEKNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHF4</accession>
    <name>F0LHF4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0219 protein TERMP_01306</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. UPF0219 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467579.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01306"/>
    <dbReference type="EnsemblBacteria" id="ADT84281">
        <property type="protein sequence ID" value="ADT84281"/>
        <property type="gene ID" value="TERMP_01306"/>
    </dbReference>
    <dbReference type="GeneID" id="10041622"/>
    <dbReference type="KEGG" id="tba:TERMP_01306"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1307"/>
    <dbReference type="eggNOG" id="arCOG01767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_7_0_2"/>
    <dbReference type="OMA" id="YAKHKGK"/>
    <dbReference type="OrthoDB" id="12601at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01409">
        <property type="entry name" value="UPF0219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004656">
        <property type="entry name" value="FabH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00748">
        <property type="entry name" value="HMG_CoA_syn_Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="223"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="350" mass="37980" checksum="575A9C050B36283E" modified="2011-05-03" version="1">MKRLLKPAKEVGIVGYGAYVPMFRIKNAEIGRVWGVNGFPIEEKAVNNLDEDALTIGIEAARNALKRAKIDPKLIRAIWFGSESKPYAVKPSATVIAEAIGATPDLDAADFEFACKAGTEALQAAIGFVGSGMAEYAMAIGADTAQGRPGDHLEFTAAAGGAAYIVGEKSSETLAYFEGSYSYVTDTPDFWRRQHEHYPRHGNRFTGEPAYFHHVISAAKGLMEELGLTVNDFDYAVFHQPNVKFPLTAAKILGIPIEKVKPGLLSGIIGNTYSGATLVGVSAVLDIAKPGERILWVSFGSGAGSDAFSLVVQDAIEEKRDLAPKTWDYINRKKYIDYALYVKHRGKLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHK6</accession>
    <name>F0LHK6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps5</name>
        <name evidence="8" type="ordered locus">TERMP_00112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts protein S4.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 6">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466388.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00112"/>
    <dbReference type="EnsemblBacteria" id="ADT83090">
        <property type="protein sequence ID" value="ADT83090"/>
        <property type="gene ID" value="TERMP_00112"/>
    </dbReference>
    <dbReference type="GeneID" id="10040431"/>
    <dbReference type="KEGG" id="tba:TERMP_00112"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.113"/>
    <dbReference type="eggNOG" id="arCOG04087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_0_1_2"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="OrthoDB" id="60954at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_A">
        <property type="entry name" value="Ribosomal_S5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_S5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="7">
        <location>
            <begin position="61"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="235" mass="26426" checksum="F80346DC3871ACB1" modified="2011-05-03" version="1">MSQDWREYAQRVLEEWQPRTKLGMLVKEGQITDIHEVFRKGYQIKEPEIVDVLLPEVNARENQQVLDIALTVRMTDSGRRVRFRVLAAVGNRDGYVGLGIGHGKEVGIAIRKAINYAKMNIIEIKRGCGSWECRCKRPHSVPFAVEGKEGSVRVKLMPGPRGLGLVIGDVGKKILTLAGVKDVWSQSFGETRTTVNFAKAVFDALYNTNRVAIKPEMIEKYGIVVGREMPQSFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHR1</accession>
    <name>F0LHR1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466443.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00168"/>
    <dbReference type="EnsemblBacteria" id="ADT83145">
        <property type="protein sequence ID" value="ADT83145"/>
        <property type="gene ID" value="TERMP_00168"/>
    </dbReference>
    <dbReference type="GeneID" id="10040486"/>
    <dbReference type="KEGG" id="tba:TERMP_00168"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.169"/>
    <dbReference type="eggNOG" id="arCOG04414">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170076_0_1_2"/>
    <dbReference type="OMA" id="RWIKVAM"/>
    <dbReference type="OrthoDB" id="131677at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="80" mass="9384" checksum="36931B7243098150" modified="2011-05-03" version="1">MNKIRGTIEIEFPSEEIAKIVYESVLFEHLSVPYRRSEIEFKREGNRIILHFTAQDNSALRGTLNSYLRWIKVAMDVAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHR4</accession>
    <name>F0LHR4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466446.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00171"/>
    <dbReference type="EnsemblBacteria" id="ADT83148">
        <property type="protein sequence ID" value="ADT83148"/>
        <property type="gene ID" value="TERMP_00171"/>
    </dbReference>
    <dbReference type="GeneID" id="26135503"/>
    <dbReference type="KEGG" id="tba:TERMP_00171"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.172"/>
    <dbReference type="eggNOG" id="arCOG01201">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_3_2_2"/>
    <dbReference type="OMA" id="INWSFHR"/>
    <dbReference type="OrthoDB" id="108083at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="107" mass="12486" checksum="E42B76EB75B0929A" modified="2011-05-03" version="1">MKDYKKIAEEFGREVSKLLGDQLVKVILFGSVARGKERENSDIDVLIIVRDNSWKIQQDVSGIVLKYLIKYGVYISVKVVTEEEFEIMRDMHSSFYHEVFREGIRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHY4</accession>
    <name>F0LHY4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA_binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467682.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01409"/>
    <dbReference type="EnsemblBacteria" id="ADT84384">
        <property type="protein sequence ID" value="ADT84384"/>
        <property type="gene ID" value="TERMP_01409"/>
    </dbReference>
    <dbReference type="GeneID" id="10041725"/>
    <dbReference type="KEGG" id="tba:TERMP_01409"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1409"/>
    <dbReference type="eggNOG" id="arCOG04227">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112567_1_2_2"/>
    <dbReference type="OMA" id="WYQARNF"/>
    <dbReference type="OrthoDB" id="99870at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="121" mass="13825" checksum="43365CCB03A0F4C2" modified="2011-05-03" version="1">MKVEGFEKIALVGASKNPAKYGNIILKDLLKKGFKVLPVNPNYDEIEGIRCYKSVEELPKDVDVIVFVIPPKACLQAVKRAVETGFKKLWFQPGAESEEIREFLESYNVDYSFYRCIMVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHY5</accession>
    <name>F0LHY5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EfeU-like ferrous iron transport permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467683.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01410"/>
    <dbReference type="EnsemblBacteria" id="ADT84385">
        <property type="protein sequence ID" value="ADT84385"/>
        <property type="gene ID" value="TERMP_01410"/>
    </dbReference>
    <dbReference type="GeneID" id="10041726"/>
    <dbReference type="KEGG" id="tba:TERMP_01410"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1410"/>
    <dbReference type="eggNOG" id="arCOG04330">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077905_0_1_2"/>
    <dbReference type="OMA" id="WYGTLLK"/>
    <dbReference type="OrthoDB" id="60388at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="284" mass="31295" checksum="9F08A25B371586D6" modified="2011-05-03" version="1">MIGQFLITFREALEAAIIVAVIIAYLKRTNRDNQIKEVWTGVGLSLLVSTMLGIIILKFYGGFEEKELFEGVASYIAVVVLTSMIYWMATKGKNIKAEIESKVSKAISPLALIGFTFIVVFREGLETVLFLTPFATQDLSGTLAGLVTGLIGALVLAYLIYGVGMKINLRTFFYYSSILLVFVAAGLAGYGTHELIEWGQEEGFNLGFLGEKAYDLGIPSDSVWSHKGAIGSVFAVLFGYSTKMEWGRVIVQFGYLIFGLYLVLRAYGKEPKLNAKRERLKTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI29</accession>
    <name>F0LI29_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospho-sugar mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466481.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00206"/>
    <dbReference type="EnsemblBacteria" id="ADT83183">
        <property type="protein sequence ID" value="ADT83183"/>
        <property type="gene ID" value="TERMP_00206"/>
    </dbReference>
    <dbReference type="GeneID" id="26135535"/>
    <dbReference type="KEGG" id="tba:TERMP_00206"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.206"/>
    <dbReference type="eggNOG" id="arCOG00768">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1182917_0_0_2"/>
    <dbReference type="OMA" id="NDMMTSY"/>
    <dbReference type="OrthoDB" id="58755at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="2">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="234" mass="26487" checksum="F4A5E2C7080A29E7" modified="2011-05-03" version="1">MEIYRSEKFNPEELALLGRAIGTVAQGTIIVGRDGRAISRYGKRALVVGIVSTGSTIMDVRLIPLIALKDFAHRKGLPLAYVYYHGGVRVEVSGLDVDEIKAIVESKNFIEAPPNDIGATVYYPNALDDFLHEIFKHHNFRVEGKALVDCMNTPAVLLFPRLNEHFGFEADLINDMMTSYLPPKPKEVFLQKLKKGEYDFGLRFKPEGIIELYKAGEEKSFGSMWKFLEYLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI32</accession>
    <name>F0LI32_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466484.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00209"/>
    <dbReference type="EnsemblBacteria" id="ADT83186">
        <property type="protein sequence ID" value="ADT83186"/>
        <property type="gene ID" value="TERMP_00209"/>
    </dbReference>
    <dbReference type="GeneID" id="26135538"/>
    <dbReference type="KEGG" id="tba:TERMP_00209"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.209"/>
    <dbReference type="eggNOG" id="arCOG01963">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104481_0_0_2"/>
    <dbReference type="OMA" id="ATNTGVW"/>
    <dbReference type="OrthoDB" id="87009at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="109"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="205" mass="22950" checksum="E3BB60BFD6190CD8" modified="2011-05-03" version="1">MEDMEEFEYQPRSVKDLFIEMKNIAELMVDLAYTSILFGDKEIAEEVVDLEERMDLLNYQMTLHAVLAARNVKEAEKVTSILQMANAIEDISNAAGDLAKMVLEGLELHPVIKEAILESEEVIAKIVVSPDSVLVGKTLGELDLATNTGVWVIAVRRGRRWIFGPDKDFKIKPHDVLIGRGTHTSVEHLKEIARGVIRVVGNERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI36</accession>
    <name>F0LI36_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00213"/>
    <dbReference type="EnsemblBacteria" id="ADT83190">
        <property type="protein sequence ID" value="ADT83190"/>
        <property type="gene ID" value="TERMP_00213"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00213"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.213"/>
    <dbReference type="eggNOG" id="arCOG02703">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1040598_0_0_2"/>
    <dbReference type="OMA" id="GCGAHAI"/>
    <dbReference type="OrthoDB" id="52812at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="50"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="267" mass="31067" checksum="0906032F791B4AF2" modified="2011-05-03" version="1">MNSEEKFKNEILPKIPLRNEPPLPNNWLQIEMLERFKVLQFAGIKEGMNILEIGCGAHAISTVPLAYMVGETGRVVAVDLARWTYFKEIIKSAGLWRRVIPMKIDAQNLPFPFKSFDLAVLIHGIRSLRNEETIVKVISEMLRVADEIFIAESLPIARTKGQETHLEMYNLREEIFEALYGRKDDLHYFQLEKLIEFVERAGGKIKECGTFEPNLPHFLAYIPRKYAEKIRDTRKREILLKKWESACEKLQKYGEEHPPVGWIKAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIL5</accession>
    <name>F0LIL5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HypE-like hydrogenase expression/formation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466587.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00312"/>
    <dbReference type="EnsemblBacteria" id="ADT83289">
        <property type="protein sequence ID" value="ADT83289"/>
        <property type="gene ID" value="TERMP_00312"/>
    </dbReference>
    <dbReference type="GeneID" id="10040630"/>
    <dbReference type="KEGG" id="tba:TERMP_00312"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.312"/>
    <dbReference type="eggNOG" id="arCOG00636">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041631_0_0_2"/>
    <dbReference type="OMA" id="RGMHDAT"/>
    <dbReference type="OrthoDB" id="34102at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="36"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="153"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="328" mass="36478" checksum="048EE6987321D090" modified="2011-05-03" version="1">MLPLGKIRSEVLNEIILDNLNIKDPKVFIGPREGFDAAVLEYSNENYLVIATDPVLGVPMEHFGFFTYHFAASDVAVFGAKPRWLVIDLLLSPGSTKEELAQIMGELNEECREYGTAVIGGHTGVYTTIKETTATTTALGLVKKEDLRLPLAKPGDDIIITKGIGIEFAVGAAYFKKEELKKFLTPAEIDKLREMYKLETVVPDALAVRKLVRGMHDATEGGLTALHEIADNSNVGFRVYYDKIYIPPLVKKVLEAFDVNPLTVSSTGTLVIISPRRNSSRIIEELSKNGIKAFIIGEFTEEKDRVLVKNSEEEEFPRFESDAYAEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIL6</accession>
    <name>F0LIL6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TilS-like tRNA(Ile)-lysidine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466588.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00313"/>
    <dbReference type="EnsemblBacteria" id="ADT83290">
        <property type="protein sequence ID" value="ADT83290"/>
        <property type="gene ID" value="TERMP_00313"/>
    </dbReference>
    <dbReference type="GeneID" id="10040631"/>
    <dbReference type="KEGG" id="tba:TERMP_00313"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.313"/>
    <dbReference type="eggNOG" id="arCOG00044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064237_0_0_2"/>
    <dbReference type="OMA" id="PYRMYEH"/>
    <dbReference type="OrthoDB" id="54396at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012122">
        <property type="entry name" value="ATPase_PP-loop_MJ1016"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036670">
        <property type="entry name" value="ATPase_UCP036670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiI" evidence="3">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="269" mass="31562" checksum="8E4275339BF38907" modified="2011-05-03" version="1">MLAEIIKETKQFAENTGLHKKKILLMFSGGKDSSLALYIMKKAGLDVSAITFFHKWSWRETLLWGMRFTEKLRVEHYLIDITEGLLKNSIGKKGPICIHCKKVMMRNAYWFAKINGFKVLAKGDNANDKIIGALLDQWKGDIRLSEIPRIGIPVFRPLIKYTAEEVEKLAKEAGIKPYRMYEYGRRRQWREGCPLQYIDKFEIIKQEYFNLAYEVNYEISKLARKYKVRMSVRVPSLKLMCHGCNEKILREADEIIRRFKNAAAWKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIL7</accession>
    <name>F0LIL7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466589.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00314"/>
    <dbReference type="EnsemblBacteria" id="ADT83291">
        <property type="protein sequence ID" value="ADT83291"/>
        <property type="gene ID" value="TERMP_00314"/>
    </dbReference>
    <dbReference type="GeneID" id="10040632"/>
    <dbReference type="KEGG" id="tba:TERMP_00314"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.314"/>
    <dbReference type="eggNOG" id="arCOG04344">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095018_3_0_2"/>
    <dbReference type="OMA" id="FVKFHAM"/>
    <dbReference type="OrthoDB" id="115659at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="122" mass="13656" checksum="77DD2AF6E1526D3D" modified="2011-05-03" version="1">MEEYGSGEVEKSKTSLGLEENIEAALAYVLGFLTGIIFLLLEKESDFVRFHAMQSTITFLGIFIIQRILMFIPFLGAILGMLLGLIGLILWILGIVKAYQGEYYKFPIVGDIAENQVRKMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIM2</accession>
    <name>F0LIM2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diadenylate cyclase</fullName>
            <shortName evidence="6">DAC</shortName>
            <ecNumber evidence="6">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="6">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dacZ</name>
        <name evidence="8" type="ordered locus">TERMP_00319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate cyclase family. DacZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466594.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00319"/>
    <dbReference type="EnsemblBacteria" id="ADT83296">
        <property type="protein sequence ID" value="ADT83296"/>
        <property type="gene ID" value="TERMP_00319"/>
    </dbReference>
    <dbReference type="GeneID" id="10040637"/>
    <dbReference type="KEGG" id="tba:TERMP_00319"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.319"/>
    <dbReference type="eggNOG" id="arCOG04453">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063222_0_0_2"/>
    <dbReference type="OMA" id="EVMKHSH"/>
    <dbReference type="OrthoDB" id="80301at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00840">
        <property type="entry name" value="DacZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014499">
        <property type="entry name" value="DAC_DacZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019073">
        <property type="entry name" value="UCP019073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="7">
        <location>
            <begin position="112"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="268" mass="29558" checksum="80A01DFC0348653C" modified="2011-05-03" version="1">MKKNGYTKILLNKALEIIKEIDAKALVLITPSFEGEIPEVEVPIILVGKDFDISDERVKKIPLPLSLGIKNVVNLISAFLVENNIISNGETFLYITPNTLGIRTVKRNIATTKGFFEEAQTVLQRLLEIAVELSLEGKEGYPVGTIFVVGDTKNVLKYSHQIVPNPFRGHKLNVLDKNIKGVIKEFATLDGAFIISNTGRIVAAGRYLDVDPKKLDVHLPPGLGSRHLAAAAISKKTKATAITLSESGVIRVFKNGEIILEYNPRMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIM4</accession>
    <name>F0LIM4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466596.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00321"/>
    <dbReference type="EnsemblBacteria" id="ADT83298">
        <property type="protein sequence ID" value="ADT83298"/>
        <property type="gene ID" value="TERMP_00321"/>
    </dbReference>
    <dbReference type="GeneID" id="10040639"/>
    <dbReference type="KEGG" id="tba:TERMP_00321"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.321"/>
    <dbReference type="eggNOG" id="arCOG01585">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OMA" id="HFRIKKL"/>
    <dbReference type="OrthoDB" id="97695at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="160" mass="18430" checksum="1E3C947484643B0C" modified="2011-05-03" version="1">MLQLDDLDRAILKLLKEDARLTISEISEKLNKPESTIHFRIKKLQERGIIGRYTIILGETLRPKHIAFLILRVEKPVIEDFLERYLEYITKTLAMLPNVLMVAKSEEDKIIALVGDETQEKLEKFIEDNIKTIPTLKEVLVFPVRTFKKGGEIIGFLAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIQ1</accession>
    <name>F0LIQ1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acylphosphate phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01528"/>
    <dbReference type="EnsemblBacteria" id="ADT84503">
        <property type="protein sequence ID" value="ADT84503"/>
        <property type="gene ID" value="TERMP_01528"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01528"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1528"/>
    <dbReference type="eggNOG" id="arCOG01674">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_1_2_2"/>
    <dbReference type="OMA" id="ISWCYIG"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="69" mass="7784" checksum="75122EBD90D84983" modified="2011-05-03" version="1">MQREARKLGVSGWVRNLPDGSVEAVIEGERERVEALIGWAHQGPIFARVTRVEVKWEEPKGEKGFRVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIR7</accession>
    <name>F0LIR7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enolase</fullName>
            <ecNumber evidence="7">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">eno</name>
        <name evidence="12" type="ordered locus">TERMP_01544</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell surface</location>
        </subcellularLocation>
        <text evidence="7">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467817.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01544"/>
    <dbReference type="EnsemblBacteria" id="ADT84519">
        <property type="protein sequence ID" value="ADT84519"/>
        <property type="gene ID" value="TERMP_01544"/>
    </dbReference>
    <dbReference type="GeneID" id="10041860"/>
    <dbReference type="KEGG" id="tba:TERMP_01544"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1544"/>
    <dbReference type="eggNOG" id="arCOG01169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_2"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="OrthoDB" id="23221at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="10">
        <location>
            <begin position="140"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="367"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="7">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT84519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="430" mass="46705" checksum="ED5927449BD584A5" modified="2011-05-03" version="1">MENPFEITAIVAREILDSRGNPTVEVDVYTPVAMGRAAVPSGASTGTHEALELRDGGRRFHGKGVRRAVENINKIIAPELIGMDVTLQRDIDMLMIELDGTENKSNLGANAILGVSLAVAKAAANTLGLPLYQYIGGTNAYVLPVPMSNVINGGVHAGNDLDFQEFMIMPVGAKSFKEGIQMISETYHTLKKILVEKYGKLAVNVGDEGGFAPPMKEVTEPLEALVRAIEETGYKVGDEIAFALDAASSEFYNAEKDKYIVGGKEYTRDELIDLYKELVSTYPIVSIEDPMHEEDFEGFAMVTRELGKKIQIVGDDIFVTNVKRLKKGIEMGAANALLLKVNQIGTLSEAIDAAYLAFRAGYGVVVSHRSGETEDATIADLAVAINAGQIKTGAPARSDRNAKYNQLIRIEEELEGIAYYPGKKFRNPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIT0</accession>
    <name>F0LIT0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketoisovalerate oxidoreductase VorB-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467830.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01557"/>
    <dbReference type="EnsemblBacteria" id="ADT84532">
        <property type="protein sequence ID" value="ADT84532"/>
        <property type="gene ID" value="TERMP_01557"/>
    </dbReference>
    <dbReference type="GeneID" id="26137245"/>
    <dbReference type="KEGG" id="tba:TERMP_01557"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1557"/>
    <dbReference type="eggNOG" id="arCOG01601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058423_0_0_2"/>
    <dbReference type="OMA" id="PCILEIG"/>
    <dbReference type="OrthoDB" id="29720at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="71"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="311" mass="34689" checksum="78A5FE546B9B0AFC" modified="2011-05-03" version="1">MEIPENIKKRLSIPFEENFYAGHTACQGCGAALGLRYVLKAYGKKAIFTIPACCSTIIAGPWPYSAFGAPLFHTAFETTGAVISGIEAALKAKGYKVKGKDGIMVVGWAGDGGTADIGLQALSGFLERGHDALYIMYDNEAYMNTGIQRSSSTPYGAWTTNTPGGKKHFLEKRHKKKVIDIVIAHKIPYAATASIAFPEDFMRKLKKAQEIPGPSFIQLFAPCPTGWRSPTDKSIELARLAVQTAYFPLFEYENGKYKINMPNPKKEPKPIEEFLKLQGRFKYMTKEDIEILQEWVLREWEELKKKAEVFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-05-16" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIT8</accession>
    <name>OGT_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="1">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ogt</name>
        <name type="ordered locus">TERMP_01565</name>
    </gene>
    <organism>
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467838.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F0LIT8"/>
    <dbReference type="SMR" id="F0LIT8"/>
    <dbReference type="STRING" id="391623.TERMP_01565"/>
    <dbReference type="EnsemblBacteria" id="ADT84540">
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    </dbReference>
    <dbReference type="GeneID" id="10041881"/>
    <dbReference type="KEGG" id="tba:TERMP_01565"/>
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        <property type="entry name" value="ATase"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MGMT_N"/>
    </dbReference>
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        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09153">
        <property type="entry name" value="DUF1938"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46767"/>
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    </dbReference>
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        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000417357" description="Methylated-DNA--protein-cysteine methyltransferase">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <sequence length="175" mass="20092" checksum="8AA790556207A181" modified="2011-05-03" version="1">MISIEKFEIFGREIWIAVFFEEKIDGVTFSLDGCEYLMERINSLKALLERRNVSVNLAEEKSDYPKIVYNVLVGDIENQDALRFLSFRGVTPFEKKVYEVLTKKVKRGSVITYGELAKMLSTSPRAVGNAMKRNPYPIIVPCHRVVLKSGLGDYTPKREYKQFLLEIEGVKGWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIU0</accession>
    <name>F0LIU0_THEBM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
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            <taxon>Euryarchaeota</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01567"/>
    <dbReference type="EnsemblBacteria" id="ADT84542">
        <property type="protein sequence ID" value="ADT84542"/>
        <property type="gene ID" value="TERMP_01567"/>
    </dbReference>
    <dbReference type="GeneID" id="10041883"/>
    <dbReference type="KEGG" id="tba:TERMP_01567"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1567"/>
    <dbReference type="eggNOG" id="arCOG11075">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1243080_0_0_2"/>
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    <dbReference type="OrthoDB" id="128484at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="222" mass="24644" checksum="0AC65CFCA37FA13F" modified="2011-05-03" version="1">MKREKLALLIYLSAFVISLYMLLSIGIVILTNEAIVLGKSVEGNTLLMMEIPTIALILLSLSYLKRKARFFAGISLFSAFVLMIVQRADIPIHVIPLAGLVLSLFALTVGFPKDKQQVSLSERMINIVIGIASIFALVRAWNFVWPNEVKPLIFLLGAIGALLMLFKNRVISSGGIPLLVTFYCSVTYALYALNHNLYGQIFWAASVVLIAYSLIPLRKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIZ9</accession>
    <name>F0LIZ9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
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            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00368"/>
    <dbReference type="EnsemblBacteria" id="ADT83345">
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        <property type="gene ID" value="TERMP_00368"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00368"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.368"/>
    <dbReference type="eggNOG" id="arCOG05840">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190385_1_0_2"/>
    <dbReference type="OMA" id="ILAKITW"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="70" mass="7761" checksum="3D61520982580A77" modified="2011-05-03" version="1">MFGYIFRERIKINLDKPMSIALLLLIFFMGVEAGRVKINAAELFATSVTFAVLTILGSLLFAVLLGGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ63</accession>
    <name>F0LJ63_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01610"/>
    <dbReference type="EnsemblBacteria" id="ADT84585">
        <property type="protein sequence ID" value="ADT84585"/>
        <property type="gene ID" value="TERMP_01610"/>
    </dbReference>
    <dbReference type="GeneID" id="10041926"/>
    <dbReference type="KEGG" id="tba:TERMP_01610"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1610"/>
    <dbReference type="eggNOG" id="arCOG03785">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1406038_0_0_2"/>
    <dbReference type="OMA" id="RENMIVV"/>
    <dbReference type="OrthoDB" id="78891at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="196" mass="22188" checksum="DE31FF140C49BA70" modified="2011-05-03" version="1">MKVYEPLMLAMPLAKWMSEFIIENKKLPTGDDVRKFLRYNNLEEICLDEGLVLHRGKFVLTLTFPAKEHIIVDIISSSGELSDALEVIAYHDRKLEAYVIEIIPANELEFEGNIGLEPVIIDDKGFELKSYPVLGHFEEEKDGVFLVIDSETYQRWGESGKLDICPICGAEGLAWRKNEAYCNSCGFGIKVKGGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ69</accession>
    <name>F0LJ69_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467889.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01616"/>
    <dbReference type="EnsemblBacteria" id="ADT84591">
        <property type="protein sequence ID" value="ADT84591"/>
        <property type="gene ID" value="TERMP_01616"/>
    </dbReference>
    <dbReference type="GeneID" id="10041932"/>
    <dbReference type="KEGG" id="tba:TERMP_01616"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1616"/>
    <dbReference type="eggNOG" id="arCOG01894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068832_0_0_2"/>
    <dbReference type="OMA" id="HIHISGI"/>
    <dbReference type="OrthoDB" id="51470at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="282" mass="32399" checksum="80B83698A39EED34" modified="2011-05-03" version="1">MKIRIDRLRFGTAGIPLSTPKPSTITGIQRVRELGLDAMELEFVRGVNISPEMAKKIKYVAQRHDVLLTAHAPYYINLNAAEKSKVEASKKRIIQSAERLHEAGGWSVVFHAGYYLKQPPETVYEKIKNEIKDIVRQLQDKGIEIWIRPELTGKPTQFGELKELIKLSQDVEMVLPAIDFAHAHARDKGKLNTAEEWREMLSLIEQELGREALDNMHIHVSGIHYTEKGEKHHLNLQESDLRWEDLLKVLKEFRVKGVVISESPNIEGDAILMKKKYERIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJB7</accession>
    <name>F0LJB7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467937.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01664"/>
    <dbReference type="EnsemblBacteria" id="ADT84639">
        <property type="protein sequence ID" value="ADT84639"/>
        <property type="gene ID" value="TERMP_01664"/>
    </dbReference>
    <dbReference type="GeneID" id="10041980"/>
    <dbReference type="KEGG" id="tba:TERMP_01664"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1663"/>
    <dbReference type="eggNOG" id="arCOG00111">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071987_0_0_2"/>
    <dbReference type="OMA" id="PTPINRY"/>
    <dbReference type="OrthoDB" id="52481at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="PTHR13393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="241" mass="27334" checksum="CDB1D824CE4AB117" modified="2011-05-03" version="1">MKMIGLKIEEALKIFPELQKYIKNGKLDFSSREARILYNKAVAKAVFDLKIEYHPKGLITPPISRYIFLKTFLRGGEKILEIGTGHSALMAIMAAKLFNCEAWATEIDEEFFEYAKRNIECNKVQVKLIKSKGQIIKGLIPEGEKFDVIFSAPPYYEKPTKGVLTPIEAVGGGEYGEKFSLKLLREAKDYLKPKGKVALFLPDKAPLLNAITQEAEKMGYRIRDIKFKAGTRVRHSLIFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJC7</accession>
    <name>F0LJC7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartokinase</fullName>
            <ecNumber evidence="1">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466691.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="SMR" id="F0LJC7"/>
    <dbReference type="STRING" id="391623.TERMP_00416"/>
    <dbReference type="EnsemblBacteria" id="ADT83393">
        <property type="protein sequence ID" value="ADT83393"/>
        <property type="gene ID" value="TERMP_00416"/>
    </dbReference>
    <dbReference type="GeneID" id="10040734"/>
    <dbReference type="KEGG" id="tba:TERMP_00416"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.416"/>
    <dbReference type="eggNOG" id="arCOG00861">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_6_3_2"/>
    <dbReference type="OMA" id="IPPRQAH"/>
    <dbReference type="OrthoDB" id="20371at2157"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011819">
        <property type="entry name" value="AspKin_pair"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02078">
        <property type="entry name" value="AspKin_pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="365" mass="40983" checksum="897F199A95BD20FD" modified="2011-05-03" version="1">MIYKLSAKSRVIIKFGGSSVRDSFSEALELVQKFHEGNEVVIVLSALKGVTDLLLKLAETRSPEILEELEEIHLGAIEKLGIELSIENEIKELRFILENEKRFPNRKAYVDYVLSFGERLSVKIFSKALEDEGIKSSPVDAFYLIETDGNFGNARVDLEKTKGNIWTIERLLEKGKIPVVTGFLGNFNGIRTTLGRGGSDYTASVLGYLLNARAVLIMSDVKGIYTADPRIVKNARIIPFISYEEALTASRLGMKALHERTIEPIKDRVPLILGKTSEWRLGTLVSDISFKMPIITYKTFRDTAEIGVVGAFHVDVEYPIVEHGRNFVCFLVERDNLEAALNEIHEVVLNESLSTSDDSELWTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJH9</accession>
    <name>F0LJH9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466743.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00468"/>
    <dbReference type="EnsemblBacteria" id="ADT83445">
        <property type="protein sequence ID" value="ADT83445"/>
        <property type="gene ID" value="TERMP_00468"/>
    </dbReference>
    <dbReference type="GeneID" id="26136017"/>
    <dbReference type="KEGG" id="tba:TERMP_00468"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.468"/>
    <dbReference type="eggNOG" id="arCOG04438">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085650_0_0_2"/>
    <dbReference type="OMA" id="DGGYCFV"/>
    <dbReference type="OrthoDB" id="118650at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016648">
        <property type="entry name" value="UCP016175_prenyltrans-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016175">
        <property type="entry name" value="UCP016175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="284" mass="32371" checksum="2E5873099E6296F9" modified="2011-05-03" version="1">MGSKLNELARYVNLNAVINYISKRRHEDGGYCFVSMLNETNINDTYYAVKIYDLLNLEIPEKEKTIEFLNSSAQPHRATVALAMAGEALAILGAEDLAREKLEYIFAKYNPLKGQFSVGLGGSEEFGAATPLESTYWVMRLVSLLNYKITDDMKEKIRDFIEGFRKGNGYGVNQPTVTMTYQAIYSLNVLGYPVPKTRFFEECEVYGGFTEVPMSLPPYLEPTFYAIRALKLLGRKPRYIKEHIRFIRALQNPNGGFRRSLELGISNFQNTYRALRALNDLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJJ3</accession>
    <name>F0LJJ3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466757.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00482"/>
    <dbReference type="EnsemblBacteria" id="ADT83459">
        <property type="protein sequence ID" value="ADT83459"/>
        <property type="gene ID" value="TERMP_00482"/>
    </dbReference>
    <dbReference type="GeneID" id="10040800"/>
    <dbReference type="KEGG" id="tba:TERMP_00482"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.482"/>
    <dbReference type="eggNOG" id="arCOG02642">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041771_2_0_2"/>
    <dbReference type="OMA" id="CFWVVQP"/>
    <dbReference type="OrthoDB" id="79655at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="346" mass="37966" checksum="D60DF9092F927C51" modified="2011-05-03" version="1">MKTESLVWLGISLIILFLVWRTVEPLISPIIFSLAIAYIFHPFHMRLSQKFGNKKSAVMLTAMMALLAGVLLIGAALWLRDVLNYLYVYIGDFFNWLLGVNLPFGIGESLHALSKTIPEKLGDILLGYTFSLPKFLLQAIVFLALFYAILTNSEFLAMEVYRLLPRENRELGIHLVERAKITLNAILRTWLMLSVLKGIFLTVGFVLFEITTVSGAIAAGILCIVLELLPVIGGWILWAIGAAYLIKTGNIALGVLFAVYGAVFISPIPDITIRPKLVAEGAKVSSVVALVGIFGGIMSFGIKGVIIGPVALGLLVTLLEEWKEQEKETLSKEPTQPSKARHSKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJM0</accession>
    <name>F0LJM0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467960.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01687"/>
    <dbReference type="EnsemblBacteria" id="ADT84662">
        <property type="protein sequence ID" value="ADT84662"/>
        <property type="gene ID" value="TERMP_01687"/>
    </dbReference>
    <dbReference type="GeneID" id="10042003"/>
    <dbReference type="KEGG" id="tba:TERMP_01687"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1686"/>
    <dbReference type="eggNOG" id="arCOG01672">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010991_1_0_2"/>
    <dbReference type="OMA" id="YNDTRYE"/>
    <dbReference type="OrthoDB" id="6885at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027552">
        <property type="entry name" value="CGP_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04288">
        <property type="entry name" value="CGP_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="27"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="930" mass="104223" checksum="276EA60A177F5B40" modified="2011-05-03" version="1">MKRSGILALLFVFVMLLGPLAAAEQGPAPDTVYISIRTNEETGITDVAKGDLDIFLWSVSGAKFKDLPADVLNNLKLIKTASGYWEITMNPVHDDDSPYLITVGEKKYFNPFAIREVRFAMNWLVSRQYIVQNILQGSGAPMIGGIRPSTGANPYFEPVYKALGISATADVAKAQKMVEEAMKKAADELAKQGHKLELKTDENGRQWWYFDGEPVTVKFIIRIEDRRKDEGLYVADLIEKFFHFKVQRLLWDRRKASSTVYLSDPKNYEWNLYTAGWVSTVNVKWPDDYTAFWYADWYGWLPAPVGWEYKPTLTVKDFIDYIGGPDKAVEALGLKYYVGDKLKELYDWTIDDVTKLLVLTSVKVNGKEYKLEEGNADQYWDLQKISMGLGIMDSIRMFTAETWEYFPVNKNRVKAIARDVSSGLWTRWSLITAETPDKVVNVAEYSATGALFMSAFNPVGGIDDVYASAIWRVVRDYPVYTDLSTGTYIPVRCDFKVERGPIKVPKTAVIWNATVKKWVSPYAGQEAKAKVTYDCKLGNWHDGQPMTMADFKYAIAFNYEWAYKNGDNDPYYDEKIANAFVDIAKQIKGYEFVDEDTIAVYTDYIHPIADDVIAANNAVWPTLPWQLLYAMSELVAKGQEYGASQKYSFSEEAEGVAQLDLLIKDHVADLRKVLEALKAKKAVPPSIANDVKDPTPGYDALIKWIDEHGNAVVSNGPFYIEKYDPDKIFVELKAFRDPTYPFSVDYWKQKLILAKLELAGVNVPTRVFTGDDLKIEVRANMVVEYPTEGTQPADKGFVYIEIRDENGNPVYTGEAKLTKAGVFEITVPGSETAKWEAGRYDIYVKGGLMEGVTSFTDKKTLIVIKKQVTSPSPSPSPSPSPSPSPTPSPSPSPSPSPSPSPSPTETKTGVCGPAALVGLALIPLLLRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJN6</accession>
    <name>F0LJN6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trk-like system potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a potassium transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467976.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01703"/>
    <dbReference type="EnsemblBacteria" id="ADT84678">
        <property type="protein sequence ID" value="ADT84678"/>
        <property type="gene ID" value="TERMP_01703"/>
    </dbReference>
    <dbReference type="GeneID" id="26137096"/>
    <dbReference type="KEGG" id="tba:TERMP_01703"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1702"/>
    <dbReference type="eggNOG" id="arCOG01957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_2_3_2"/>
    <dbReference type="OMA" id="QRCNVVI"/>
    <dbReference type="OrthoDB" id="116057at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="141"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="227" mass="25240" checksum="ABCBCA2A4B2D702A" modified="2011-05-03" version="1">MFVVIMGAGRVGYLVAKMLEAEGHDVTIIEMNKERAKELSLLINGLVIEGDATDQKTLEEANIKQADAFAALTGRDDANLLACILAKHLNPKVTTILRVSNPKNKEVFERVEDLKRYFDFVISPEEIAANYIFRSIVTPGFDRVLFPKEGAEIVQFKIDENSEVAEKVVKDLGLPKDSLIVAIYDEKGNLVIPSGDTKLPKKGQIVIFAKNNALKEIKSLIEKKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJQ1</accession>
    <name>F0LJQ1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467991.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01718"/>
    <dbReference type="EnsemblBacteria" id="ADT84693">
        <property type="protein sequence ID" value="ADT84693"/>
        <property type="gene ID" value="TERMP_01718"/>
    </dbReference>
    <dbReference type="GeneID" id="26137080"/>
    <dbReference type="KEGG" id="tba:TERMP_01718"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1717"/>
    <dbReference type="eggNOG" id="arCOG00915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_2"/>
    <dbReference type="OMA" id="PLVPYNA"/>
    <dbReference type="OrthoDB" id="20774at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="460" mass="50417" checksum="740596D27BDCE7B1" modified="2011-05-03" version="1">MSFNEFPKIVVKPPGPKAKELIEREKKVISSGLGVKLFPVVPERGYGALIEDVDGNVFIDFLAGAAAASTGYAHPELVKEVQEQVAKIQHSMIGYTYSKRAIEVAEILAEKAPIENPKILFGLSGSDAMDLTMKVARFATRKPWFIAFIGAYHGQTYGATSIAAFQSSQKRGFSPLVPNVVWIPYPNPYRNVWGINGYEEPDELINRFLDYLESYILAHVVPPDEVAALIAEPIQGDAGIVVPPENFFKELKKVLDEHGILLAMDEVQTGIGRTGKWFATEWFKVKPDFISFGKGVASGMGLSGVIGRAELMDMTSGSALLTPAANPVISAAAYATLKIIEEEKILENAQKVGAFIMKRLKEMQEKYDVIGDVRGKGLMIGVEIVKPDGKPDPELTGKICWRAFELGLILPSYGMFGNVIRITPPLVITEEIAEKGLEIMEQALKDALAGKVTHKVVTWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJQ7</accession>
    <name>F0LJQ7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467997.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01724"/>
    <dbReference type="EnsemblBacteria" id="ADT84699">
        <property type="protein sequence ID" value="ADT84699"/>
        <property type="gene ID" value="TERMP_01724"/>
    </dbReference>
    <dbReference type="GeneID" id="26137073"/>
    <dbReference type="KEGG" id="tba:TERMP_01724"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1723"/>
    <dbReference type="eggNOG" id="arCOG00818">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_9_3_2"/>
    <dbReference type="OMA" id="GFKDFDK"/>
    <dbReference type="OrthoDB" id="130137at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="80" mass="9319" checksum="03DF71275EB68B25" modified="2011-05-03" version="1">MVTVTRKYQVTIPKEVREALNIKAGDEVVFVKTKEGYVIMKFEDLLEEMTELSKDIDETTEEMREGLSKIFRRKADEDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJS3</accession>
    <name>F0LJS3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84715">
        <property type="protein sequence ID" value="ADT84715"/>
        <property type="gene ID" value="TERMP_01740"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01740"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1739"/>
    <dbReference type="HOGENOM" id="CLU_3148152_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="48" mass="5637" checksum="2F34ED52E8E72352" modified="2011-05-03" version="1">MIWSEKPLNSRLALTALLTLQQKAFIIQAFLYFYWGNKAKSRPVPIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJU9</accession>
    <name>F0LJU9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00509"/>
    <dbReference type="EnsemblBacteria" id="ADT83486">
        <property type="protein sequence ID" value="ADT83486"/>
        <property type="gene ID" value="TERMP_00509"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00509"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.509"/>
    <dbReference type="eggNOG" id="arCOG07148">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146473_0_0_2"/>
    <dbReference type="OMA" id="AYKRETV"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="138" mass="16416" checksum="6AC4D9CD59E4CA84" modified="2011-05-03" version="1">MITGDAKKITRIFLNAWLSNGMTFLAEHLPFDVKYPGNVFIGSLNEGIEFDGYLIYNLLSRPKNERARVYEWIKEHSNKLILIYETKYMKDSVLRYGIKELINYLIAYKRETLGFERIDVYKFEEGRVVEKKTYVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJV4</accession>
    <name>F0LJV4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466789.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00514"/>
    <dbReference type="EnsemblBacteria" id="ADT83491">
        <property type="protein sequence ID" value="ADT83491"/>
        <property type="gene ID" value="TERMP_00514"/>
    </dbReference>
    <dbReference type="GeneID" id="10040832"/>
    <dbReference type="KEGG" id="tba:TERMP_00514"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.514"/>
    <dbReference type="eggNOG" id="arCOG01005">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067263_0_0_2"/>
    <dbReference type="OMA" id="YLPERWY"/>
    <dbReference type="OrthoDB" id="59250at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="326" mass="35955" checksum="1D480916F4DA10DB" modified="2011-05-03" version="1">MRAKALILILILTSLLSPEVSAEKPLIVASIPPLAEIVKEVFGDSVDVVYIVPPGADPHQYQLTPEQIDLIKKADVVVTANGHLPAEQKMKQLKEEGTITADVLFAEDYGKYGFRFLPERWYNNKNNPHGIWLDPYNALAIAKATAEALSERYPQNRELYVRQYERFETKVLAIVKAYKALAENSTAIIELPSQQYALEWLGVKAVASIKPEAEVPAKSVDEMLKTANAVDFIAYSSKSPEALKNAAIELAQRSGKPLADITTIWVNKPYTEVLIENSKAIVSVLNQKTTPIQQTTKAENINVTYIILSLIVGISLGMAVGALIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJY0</accession>
    <name>F0LJY0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S cluster-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466815.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00540"/>
    <dbReference type="EnsemblBacteria" id="ADT83517">
        <property type="protein sequence ID" value="ADT83517"/>
        <property type="gene ID" value="TERMP_00540"/>
    </dbReference>
    <dbReference type="GeneID" id="10040858"/>
    <dbReference type="KEGG" id="tba:TERMP_00540"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.541"/>
    <dbReference type="eggNOG" id="arCOG01543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140144_0_0_2"/>
    <dbReference type="OMA" id="FECNEAC"/>
    <dbReference type="OrthoDB" id="108931at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="125" mass="14294" checksum="255BFF1D76FD82BA" modified="2011-05-03" version="1">MLRSELCIGCAACANACPFDAIGIVDNNKRVIHFSPEKCSNCSFECNDVCPTRAIERRPDKITLEFEYAFCLECGRRLMRTKKEAEYYAQQLLKMGEKVEFAFICDECKMKKISSVSDKYSGYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJY2</accession>
    <name>F0LJY2_THEBM</name>
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        <submittedName>
            <fullName evidence="2">Fe-S-cluster-containing hydrogenase components 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466817.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00542"/>
    <dbReference type="EnsemblBacteria" id="ADT83519">
        <property type="protein sequence ID" value="ADT83519"/>
        <property type="gene ID" value="TERMP_00542"/>
    </dbReference>
    <dbReference type="GeneID" id="10040860"/>
    <dbReference type="KEGG" id="tba:TERMP_00542"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.543"/>
    <dbReference type="eggNOG" id="arCOG01500">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_3_3_2"/>
    <dbReference type="OMA" id="MARMKFV"/>
    <dbReference type="OrthoDB" id="105930at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="168" mass="18778" checksum="3D63426775CB30CA" modified="2011-05-03" version="1">MARRILHVDYSLCIGCETCQSVCDFLHHGKPNIRIYYTESGLPIPINCRHCEKAPCMNVCPSNAIYKDTDGAVIIDPKKCIGCLMCLAVCPFGAPSYDARLKVVTKCDMCADRRRVGLEPACSEMCPAEAVFFGRPEEVEDEIRRRTAEKIARERISSTVMESIGRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK24</accession>
    <name>F0LK24_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01761"/>
    <dbReference type="EnsemblBacteria" id="ADT84736">
        <property type="protein sequence ID" value="ADT84736"/>
        <property type="gene ID" value="TERMP_01761"/>
    </dbReference>
    <dbReference type="GeneID" id="26137274"/>
    <dbReference type="KEGG" id="tba:TERMP_01761"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1760"/>
    <dbReference type="eggNOG" id="arCOG02177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086260_0_0_2"/>
    <dbReference type="OMA" id="PMYTREG"/>
    <dbReference type="OrthoDB" id="32299at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002749">
        <property type="entry name" value="DUF63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40700">
        <property type="entry name" value="PTHR40700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01889">
        <property type="entry name" value="DUF63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="264" mass="30932" checksum="7B7C19DF79AD0235" modified="2011-05-03" version="1">MLESIKEFFWIYFIRPMYTREGYNPYNTLVYAFLLGLGVIYSYKYIIKPLKIKVDEKLFWAVTPMVVFGATVRALVDGGVLKPNPLILTPGIFFTAFFLIVPALIADAKLKTYPKVTIAWGTILALYANYLLVTHVKSFKPYELTIFWTVIFILPVLIFYRFKPFEKMYLYPVLAHLFDIGSTVVAIHYYGYREVHWLENILVTKFGAFIYYPWILFILIVVYYGLKWLVPDEEERRYWYLAIYILGLGPAIRDPAQMILQLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK26</accession>
    <name>F0LK26_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TrmB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468035.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01763"/>
    <dbReference type="EnsemblBacteria" id="ADT84738">
        <property type="protein sequence ID" value="ADT84738"/>
        <property type="gene ID" value="TERMP_01763"/>
    </dbReference>
    <dbReference type="GeneID" id="10042079"/>
    <dbReference type="KEGG" id="tba:TERMP_01763"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1762"/>
    <dbReference type="eggNOG" id="arCOG00395">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2420204_0_0_2"/>
    <dbReference type="OMA" id="ASCENGK"/>
    <dbReference type="OrthoDB" id="123460at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="91" mass="10624" checksum="C8C5942A86B74F40" modified="2011-05-03" version="1">MRTHLLKASCENGKLILFLRIEIDLEHAYKVELTELERDVLEFILQNGEVTQKGLSNKFGKVRACRVIQNLEKKGLIERKKKGRTYVIRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK51</accession>
    <name>F0LK51_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elp3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468059.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01788"/>
    <dbReference type="EnsemblBacteria" id="ADT84763">
        <property type="protein sequence ID" value="ADT84763"/>
        <property type="gene ID" value="TERMP_01788"/>
    </dbReference>
    <dbReference type="GeneID" id="10042104"/>
    <dbReference type="KEGG" id="tba:TERMP_01788"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1787"/>
    <dbReference type="eggNOG" id="arCOG05825">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067819_1_0_2"/>
    <dbReference type="OMA" id="IYECCVM"/>
    <dbReference type="OrthoDB" id="63102at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Elp3" evidence="5">
        <location>
            <begin position="13"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="275" mass="31351" checksum="E284D0D192F4A105" modified="2011-05-03" version="1">MRKLKIYIPGIKFPSISLTGGYCSLNCAHCGKHYLEGMLKVTRSSLVEYCKSLEREGYVGCLLSGGLDNRLKVPLDKFAEEIKAIKRETKLKLNAHVGFIDEKDLGWIKYVDAVSLDFVGADEVIKRVYKIDKTVKDYLKILDILTENGVRVAPHITIGLDFGKIWWEYKAIDMLVEYPIDVLVLDVLIPTKGSEMENVEKPSVEESLEVVRYARERFDGELSIGCMRPLGKWRLEFDRGAILAGVDRITNPPRKVIEWAKTVREVEIIYECCVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK52</accession>
    <name>F0LK52_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468060.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01789"/>
    <dbReference type="EnsemblBacteria" id="ADT84764">
        <property type="protein sequence ID" value="ADT84764"/>
        <property type="gene ID" value="TERMP_01789"/>
    </dbReference>
    <dbReference type="GeneID" id="10042105"/>
    <dbReference type="KEGG" id="tba:TERMP_01789"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1788"/>
    <dbReference type="eggNOG" id="arCOG00968">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080487_1_0_2"/>
    <dbReference type="OMA" id="KTFVVEH"/>
    <dbReference type="OrthoDB" id="116150at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="RNA_MeTrfase_TK0422/Sfm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PTHR35517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="RNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="210" mass="24319" checksum="1E1F7DF57B7115FE" modified="2011-05-03" version="1">MPYLIIEHLEEISEWLWLEYKHVSEWWKDKLIFTNVREDEREKLAKLGSVLTESVTKFPFDRSKIIVLDLQAEEELKPEDINEDTIIVVGGILGDAVPRGRTKEFITSKMEGAKVRHIGKPQYSIDGAAIVAKLIADGKRLEEIEYEENPTIKLDEFSEITLHYAVPKLNGKLLLTPGLIELQKKELGYFDEEEISDEELEEFFEGKREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK91</accession>
    <name>F0LK91_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468099.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01828"/>
    <dbReference type="EnsemblBacteria" id="ADT84803">
        <property type="protein sequence ID" value="ADT84803"/>
        <property type="gene ID" value="TERMP_01828"/>
    </dbReference>
    <dbReference type="GeneID" id="10042144"/>
    <dbReference type="KEGG" id="tba:TERMP_01828"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1827"/>
    <dbReference type="eggNOG" id="arCOG03787">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_938822_0_0_2"/>
    <dbReference type="OrthoDB" id="50807at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="296" mass="33636" checksum="D839580B56CEBC25" modified="2011-05-03" version="1">MKKAVVLILLLMVLVGIYYKAGDYIASAYVSEVRLNLIGVSDNSVVFRMSLVVSNPITLDVRYAPHNLTLYYDDHPLAVVRTSSGVLAGGSKNVVIYEGKIPTETLKEWFYYYATHRWHSTLYVRGRIIVEFGPVKAPIYVHSKVADVSSNPFIEIINKEFPGRKENVGYYRLRYPSVKFSGVTWDGRTLRMKLTYINNSTSPILVQFPTYEFRANNITLGTTVTDSILIPGKSIVESEVAMDTQNIEKFLFLHFANGETTVFEISMEGAIKYLGITKRGKIFDIKFTYRTDIFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKD8</accession>
    <name>F0LKD8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA (Guanine37-N1)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466894.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00619"/>
    <dbReference type="EnsemblBacteria" id="ADT83596">
        <property type="protein sequence ID" value="ADT83596"/>
        <property type="gene ID" value="TERMP_00619"/>
    </dbReference>
    <dbReference type="GeneID" id="10040937"/>
    <dbReference type="KEGG" id="tba:TERMP_00619"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.621"/>
    <dbReference type="eggNOG" id="arCOG00033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022610_0_1_2"/>
    <dbReference type="OMA" id="HYYDIQH"/>
    <dbReference type="OrthoDB" id="55502at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040601">
        <property type="entry name" value="Trm5_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18093">
        <property type="entry name" value="Trm5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="3">
        <location>
            <begin position="83"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="330" mass="38261" checksum="A7D60ED99D04B0EA" modified="2011-05-03" version="1">MLGIRVHKHEGEKVRRKLIELDVLDKNYKVKREGDFLIFPIKERVEGFEIVETEFEPIEKRPHSYREVVDVPDYLRSLLPSSFDIIGDIAVIELSEELMEYGKQIGEAILKVHKHIKAVFAKGSAVSGEFRIRQLIHLAGEKRTETLHRENGIKLKLDVAKVYFSPRLATERMRIFKKAKEGEIVFDMFAGVGPYSILLAKKVRLVFACDINPWAVKYLEENKRLNKTPNVIPILGDVRKVAGQIKADRVIMNLPKFAHEFLREAMLSVKSGGIIHYYGFSHEDDLFGKHEEKIKTVARELGKKVKFLERRKVRPYAPYQYNIAIDFRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKF8</accession>
    <name>F0LKF8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3216 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466914.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00639"/>
    <dbReference type="EnsemblBacteria" id="ADT83616">
        <property type="protein sequence ID" value="ADT83616"/>
        <property type="gene ID" value="TERMP_00639"/>
    </dbReference>
    <dbReference type="GeneID" id="10040957"/>
    <dbReference type="KEGG" id="tba:TERMP_00639"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.641"/>
    <dbReference type="eggNOG" id="arCOG07142">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2299495_0_0_2"/>
    <dbReference type="OMA" id="AIERFIT"/>
    <dbReference type="OrthoDB" id="120330at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023108">
        <property type="entry name" value="DUF3216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038317">
        <property type="entry name" value="Pf1176-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11505">
        <property type="entry name" value="DUF3216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3216" evidence="1">
        <location>
            <begin position="5"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="95" mass="11109" checksum="9E8FF53E6C3A1A64" modified="2011-05-03" version="1">MHIMEELKTLCRELGEESLIPRIESFIALNKEFESKKGKEFVEVSILGFAEGILTTLKLKYPENEKVRSLLEKVSTQRKELDIKFRKPKPPIFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKI0</accession>
    <name>F0LKI0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Motifprokaryotic membrane lipoprotein lipid attachment site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468110.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01839"/>
    <dbReference type="EnsemblBacteria" id="ADT84814">
        <property type="protein sequence ID" value="ADT84814"/>
        <property type="gene ID" value="TERMP_01839"/>
    </dbReference>
    <dbReference type="GeneID" id="10042155"/>
    <dbReference type="KEGG" id="tba:TERMP_01839"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1838"/>
    <dbReference type="eggNOG" id="arCOG00153">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052600_0_0_2"/>
    <dbReference type="OMA" id="WDHTARI"/>
    <dbReference type="OrthoDB" id="14670at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="445" mass="49082" checksum="1DE64BD50E171BB7" modified="2011-05-03" version="1">MKKVKTMFGLFLVGLIVFAVAASGCIGGEKTTTPTGTQTTPTQSTTPAKIVWVSTQLAPPEERAFVKETLLANFKKQYGIDVDFIPMSYTDLSTRLAGEEKTGKVTIDVIGDLHGGLDYFNSQGWLMDLSKMPKLEGRTFITSFEKYATINGKKVYVPWMSATYVMVVNKKAFDYLPAGLTKDDVIKGTDKWTYDAFLAWAKNLYEKTGKPQVGFPAGPNGLFVRFLHGYLYPSFTGYEAKAFDSPEAVTMWNYLKELWKYVNPASTTWDAMSDPLLTGQVLIAWDHTARIKNAIQTKPDEFVVVPVPRGPKGRGFIVVLAGLAIPKGAPNPDAAWKLIDYLTKPETQVEVLKNVGFFPTVKEATNAIPEGPLKILAEGVTAQSSTPDALIVMIPNLGDKGGEFKNIYKEAFRRIVLQGEDPQKVISELGPKLLQLFKEKGIEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKL2</accession>
    <name>F0LKL2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468142.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01871"/>
    <dbReference type="EnsemblBacteria" id="ADT84846">
        <property type="protein sequence ID" value="ADT84846"/>
        <property type="gene ID" value="TERMP_01871"/>
    </dbReference>
    <dbReference type="GeneID" id="10042567"/>
    <dbReference type="KEGG" id="tba:TERMP_01871"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1870"/>
    <dbReference type="eggNOG" id="arCOG03786">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1346456_0_0_2"/>
    <dbReference type="OMA" id="REEYRCP"/>
    <dbReference type="OrthoDB" id="54198at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="227" mass="25934" checksum="1AD60D17E35454E5" modified="2011-05-03" version="1">MKLIPSIAYLRVQRQYFIGYSMPLAGWIGEHLLIRGSFPKPLFLKRALAKLGFSLAGENVDDETYVYFFTKKNLGLTAYFEPESALFVQLYPLNKRLSSGITIRAQHIEFYDQDVVSIEPAQKLPPKIRSIGINALILEDKVPISIPYWGMVHEDWENELKILVMLDEVFGELEEKEYRCPICFSPLRVEGSALKCDTCGFIFTAESDFDKVLSEFSLGVGEEEIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKL4</accession>
    <name>F0LKL4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase II small subunit</fullName>
            <shortName evidence="12">Pol II</shortName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Exodeoxyribonuclease small subunit</fullName>
            <ecNumber evidence="12">3.1.11.1</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">polB</name>
        <name evidence="15" type="ordered locus">TERMP_01873</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Heterodimer of a large subunit and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EC" id="3.1.11.1" evidence="12"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468144.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01873"/>
    <dbReference type="EnsemblBacteria" id="ADT84848">
        <property type="protein sequence ID" value="ADT84848"/>
        <property type="gene ID" value="TERMP_01873"/>
    </dbReference>
    <dbReference type="GeneID" id="10042189"/>
    <dbReference type="KEGG" id="tba:TERMP_01873"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1872"/>
    <dbReference type="eggNOG" id="arCOG04455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027850_1_0_2"/>
    <dbReference type="OMA" id="FIGPGNH"/>
    <dbReference type="OrthoDB" id="11652at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008852">
        <property type="term" value="F:exodeoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000738">
        <property type="term" value="P:DNA catabolic process, exonucleolytic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00325">
        <property type="entry name" value="DNApol_II_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011149">
        <property type="entry name" value="Pol2_small_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="PTHR10416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000803">
        <property type="entry name" value="Arc_Pol2_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_E_B" evidence="14">
        <location>
            <begin position="413"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADT84848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="677" mass="76243" checksum="125FB9A82F365B2C" modified="2011-05-03" version="1">MNELVKDLLSNRYLITPPAYFILSEYYRKNFTLAELIKFARTKNTFVIDERLAKEFLESKGLLSPLENFAKYIPKASVETKAETPSSIPGVPMEISISKGSKEISIQSAVGGEKTAKLGKMVEIPPQASDKTEIAHDIQELPSEKGTSISTGEPMENMVSETISTEIVEEEPTIEGGESFISTGAPSPEEYTGAGDEENGVKMKAVYGDYGVLVPLEEEEIPAEERRAYSIYEDFKVEPNESFEFVAKRIKAEYEIKFDVRNVKLKPPKAKNANGKEGEVVVKVYENYFKSRLKKLRRILRENPEVSGVIDIGKLSYINPEGEVTIIGLVNSKRETKKGFIFEVEDMTGIVKVFLGRDNEDYKKAFEVLPDSVVAFRGYYSKRGILFASKLYLPDVPLYKREKPPLEEKVYAVLISDIHVGSTKFCEKAFMKFLEWLNGNVESREEEEIVSRIKYMIIAGDVVDGIGIYPGQYNELAIPDIFDQYEALANLLANVPDHITMFIGPGNHDAARTALPQPEFYREYAKPLYELKNAVIISNPAVINLHGRDFLIVHGRGIEDVVSYIPGKSHLHPVEPMIELLKLRHVAPTFGGKVPIAPDPEDLLVIEEVPDLVQMGHVHVLDYQIYRGVFLINSATWQAQTEFQKMVNIVPTPARVPIIDIETARLKTVVDFSRWCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKV3</accession>
    <name>F0LKV3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00705"/>
    <dbReference type="EnsemblBacteria" id="ADT83682">
        <property type="protein sequence ID" value="ADT83682"/>
        <property type="gene ID" value="TERMP_00705"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00705"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.706"/>
    <dbReference type="eggNOG" id="arCOG05815">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082327_0_0_2"/>
    <dbReference type="OMA" id="WILMIAP"/>
    <dbReference type="OrthoDB" id="113576at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="311" mass="34183" checksum="3AC9ADDBA12511A9" modified="2011-05-03" version="1">MGAINAFAKTIETITKNPKLLLIPIIIALIIAPISAYLLKNYTALFTEEMQKNFEQKQEGNVIVEEHGSIIPKENMEKFMSYIKIIILLGILSALLNAIGQYAVVKGALTAEKGEEYSLIQLFVDGIKNMIQVFVVNVIIGLIIFVIIMVPLIPAFLMLAAGAMLKSEAFFMMVLFFVLLLELPLVFFLVGLGSMAVPIYVIKGSIGAAFECFSVAFKNKLSTLAFGILLLISVILIMVVPGSFMGLMALGSSGFTAQLLLNLIEAPFQALTQAVMSIGGLMLYLELTKEEKDLEEEILEEVQKELNEFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKW2</accession>
    <name>F0LKW2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00714"/>
    <dbReference type="EnsemblBacteria" id="ADT83691">
        <property type="protein sequence ID" value="ADT83691"/>
        <property type="gene ID" value="TERMP_00714"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00714"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.716"/>
    <dbReference type="eggNOG" id="arCOG04253">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061722_0_0_2"/>
    <dbReference type="OMA" id="VIQQGMN"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008482">
        <property type="entry name" value="DUF763"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38597">
        <property type="entry name" value="PTHR38597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05559">
        <property type="entry name" value="DUF763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="384" mass="43863" checksum="4B4D146DCAFB5B78" modified="2011-05-03" version="1">MMRKGIAELPLHGGHVPLWLAQRMKKLARLVLILLVDEYGTKGVLERLADPVWFQALNNLIGMDWDSSGSTTVTTGILKEVLSKEELGIKAAGGKGAKSRETPAQLREICEKYGLDSSEYVRISRLVAKVDTVALQTGYQLYHHVFFLDEEGNWAVVQQGMNPKVKLARRYHWFDNESFTLEPHKGISGIKLEYALNTVDKNTREYQKILLDIVKEDPRKLERELKTLTAVAKGYKPLVVYKPYEKLNLSDTVRRYKSLGQIELNQRALELARELSVKNYEEFLLLKGLGPSTLRALSLVLELVYDVHPSWRDPVTHPPDPFKFAYAVGGKDRVPFPIDKPTYDELISFLEKLVEKNPQERQIVKAVTKITKNWKPPEEDKKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL06</accession>
    <name>F0LL06_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable L-aspartate decarboxylase</fullName>
            <shortName evidence="4">ADC</shortName>
            <ecNumber evidence="4">4.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mfnA</name>
        <name evidence="6" type="ordered locus">TERMP_01938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family. MfnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468209.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01938"/>
    <dbReference type="EnsemblBacteria" id="ADT84913">
        <property type="protein sequence ID" value="ADT84913"/>
        <property type="gene ID" value="TERMP_01938"/>
    </dbReference>
    <dbReference type="GeneID" id="10042254"/>
    <dbReference type="KEGG" id="tba:TERMP_01938"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1937"/>
    <dbReference type="eggNOG" id="arCOG00027">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028929_2_1_2"/>
    <dbReference type="OMA" id="DPHKMGL"/>
    <dbReference type="OrthoDB" id="44488at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01610">
        <property type="entry name" value="MfnA_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020931">
        <property type="entry name" value="MfnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03812">
        <property type="entry name" value="tyr_de_CO2_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4 5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="386" mass="42754" checksum="CD994DAD58FD519A" modified="2011-05-03" version="1">MVTFPEKGMSEEEVLDELEKRLSEDLTFDSGKILGSMCTYPHPLAQKIISLYMDRNLGDPGLHVGSRKIEEEAVQMLGNLLHLNKAYGNIVSGGTEANILAVRAFRNIADIENPELILPESAHFSFLKASEMLKVKLVWAELNKDYSVNVRDIESKITDNTIGIVGIAGTTGLGVVDDIPALSDLAQDYGLPLHVDAAFGGFVIPFAKALGYDLPDFDFKLKGVQSVTIDPHKMGMVPIPAGGIIFRKKRFIDAISIPAPYLAGGKVFQATITGTRPGANALAVWALLKHLGFEGYKRIVKEAMELSRWFAGQIRTLKGAYLIREPMLNIVSFGTKELEKVEKELKRRGWGISAHRGYIRIVMMPHVKKEHLEEFLKDLKEILKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL11</accession>
    <name>F0LL11_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CARDB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468214.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01943"/>
    <dbReference type="EnsemblBacteria" id="ADT84918">
        <property type="protein sequence ID" value="ADT84918"/>
        <property type="gene ID" value="TERMP_01943"/>
    </dbReference>
    <dbReference type="GeneID" id="10042259"/>
    <dbReference type="KEGG" id="tba:TERMP_01943"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1942"/>
    <dbReference type="eggNOG" id="arCOG02532">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008925_0_0_2"/>
    <dbReference type="OrthoDB" id="619at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARDB" evidence="1">
        <location>
            <begin position="440"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="866" mass="95254" checksum="6C2E55075291008E" modified="2011-05-03" version="1">MKKGPSFVIVVLIVLGLVPAVSGLYGTKVLDGSLGDWGTLDYIATANDNGLAGANLNNLYVAWDDEYLYIMITTRNSQSWDLAYGIGIDVDPGTGNGYTGDMDAWGRRIGFGNGYAIDYEIYFWYSGGSGITADNFITWTGGGWDYKALADVGAGFAYTGDTSTGLQTLEVKIPWTALGGKPEKLALIAWIAGGGDSSAVSSVPWDPAMESLDEPYASWFNGDEWGDTDYFTNLAEIQIAPKTIDGNLSDWKNYEIVGVSTLDGPDGADLDKLYVSYDDQYLYIALTTNNTASWGIVYGFGLDVKDGGYTGDTDAWGRKIGFSRGVDYEIYFWYDAGNDKIGGGNFITWTGNGWEYQDVGSVVTYAATCGNGLQILEMAIPWSAIGGRTSELAIIAWVAGSFGGDSAVDTVPLDPDVDGNDWTDQDYLSNFAVIEIPIPKPELTVKLSSNVLDIEPWQPANLTVEVQNLGKVDAKNVKVELYDNDELLSSWIVNVSAESSVSLVYTYEYPGSWGTHVFKAVVDPENVIQEVNEENNIATLELEIGKAVKTQSDMINLGKYVWPRLYEKKYPIVQELLQNITRAKLPAKYQENLTKFQMQLNESLSMFNEGKEMIGIRNMELRGSLKIFAAYSRLLRIQREVEKFLSAVQGELLANKLTKKIDGNLDDWSPETLVYEDTTGFGQQGANLKALYVDYDDNFLYIALTTENKASWRIAYGFALDYKDGGYTGDTDGWGRKISFTRGVDAELYFWWFGEFFGEKGTDRIETMQLVLWNGTGWQYYNLQDIGFAAWTGSTNGLQTLEVAIPWDALGGKPAKIGIVAWITGANAGDSAVETLPDDPSVHDLDPGQEWTDADTISTFAEVTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL14</accession>
    <name>F0LL14_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01946"/>
    <dbReference type="EnsemblBacteria" id="ADT84921">
        <property type="protein sequence ID" value="ADT84921"/>
        <property type="gene ID" value="TERMP_01946"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01946"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1945"/>
    <dbReference type="eggNOG" id="arCOG02231">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046973_1_0_2"/>
    <dbReference type="OMA" id="SVYSFCM"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="4">
        <location>
            <begin position="45"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="495" mass="55322" checksum="53D7BC8848C105C7" modified="2011-05-03" version="1">MHTANLGKGYMVSFEEKFDVVIIGAGPAGLFAAYELAEKSDFKIAVIDEGGDIDQRVCPMYEVGYCVGCKPCHIMSGVGGAGGLSDGTINLRPDIGGDLTELTHDENYSWQLVWEVDQIFLRHGAPRRLYKGNEEQIREWERRAAQAGVKFIPIIQRHIGSDHTKEVIKSIKEYLESKGVKFILWTKVEEFRQSEVVARRRNRLFTIKARYIIVAPGRGGADWFHEVAQKIGLKARHGPIDVGVRVEVPAIVMEPITSINHDPKFHIYTDTYDDFVRTFCTNPYGFVVEERYDSYVGVNGHSMRDRKSNNTNFAFLSRIELTEPVEDTTAYGKSIAQLATTIGGGKPILQRLGDLRRGRRSTWARIRKSNVEPTLKHVTPGDIAMALPHRVVTNIIEGLEKLDKVIPGVASDHTLLYAPEIKYYAMRAEVNEDLETSIENIFAAGDGAGLSRDIVNAAATGLLAARGILKKEGNYTEKDFKKPGNWKKRIESLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL16</accession>
    <name>F0LL16_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01948</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468219.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01948"/>
    <dbReference type="EnsemblBacteria" id="ADT84923">
        <property type="protein sequence ID" value="ADT84923"/>
        <property type="gene ID" value="TERMP_01948"/>
    </dbReference>
    <dbReference type="GeneID" id="10042264"/>
    <dbReference type="KEGG" id="tba:TERMP_01948"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1947"/>
    <dbReference type="eggNOG" id="arCOG01953">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_2"/>
    <dbReference type="OMA" id="TTFSHEG"/>
    <dbReference type="OrthoDB" id="79669at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="10"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="380" mass="40175" checksum="453CA15E04428617" modified="2011-05-03" version="1">MDVFLELATILIAAKIFGYLATKIKMPAALGQLVGGIIIGPSILRFVSYSEEVHLISELGIVLLLFLAGLETDVEEFKRVGVPAFLVAVGGVAVPLILGYASALFFGYSKVQALFLGGVLTATSVGLTASILMEMKKLRGKEGTTILAAAVVDDVLGIIVLTILVALNTKGHVYIEDLLILLGEVAFFFAVSILLGTPAIKEALKLSSKIELPETVTAFALSITLIFAYIAEKFQIAGITGAYLAGLIIAQTDEARRITTKIMTIAYSLFVPVFLVSIGIKSDIGTLLHAGTFALIYALVGVFGKIVGCGAGALLAKFKPKEALRVGVGMIPRMEVALIMANVALTEGVFDQGIFSIPVTMVIITTLITPPLLKLAFARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL27</accession>
    <name>F0LL27_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01960"/>
    <dbReference type="EnsemblBacteria" id="ADT84934">
        <property type="protein sequence ID" value="ADT84934"/>
        <property type="gene ID" value="TERMP_01960"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01960"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1958"/>
    <dbReference type="HOGENOM" id="CLU_2434018_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="90" mass="10668" checksum="4F60BD5ADF379F65" modified="2011-05-03" version="1">MNGVQKLKEIRRIVKEELKHIPRGDEAQNMLRMIYWNARLNSLGKKPKFKNKEECLKYAIKVVQETYPGFSPQYDKEFFELDDTDTGDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL55</accession>
    <name>F0LL55_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468258.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01988"/>
    <dbReference type="EnsemblBacteria" id="ADT84962">
        <property type="protein sequence ID" value="ADT84962"/>
        <property type="gene ID" value="TERMP_01988"/>
    </dbReference>
    <dbReference type="GeneID" id="10042303"/>
    <dbReference type="KEGG" id="tba:TERMP_01988"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1985"/>
    <dbReference type="eggNOG" id="arCOG02698">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846264_0_0_2"/>
    <dbReference type="OMA" id="MWIESED"/>
    <dbReference type="OrthoDB" id="101317at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="294" mass="32348" checksum="52483A66083C4099" modified="2011-05-03" version="1">MILIGSSGNFREYESQRGIWVQISQGNEAYIAYFCTDDGYSTTVTVEQGSFASFNALTIRNQLGETLEARIELSNALLPSIDVELENGWVTLFDQEEYSFEGNVSVASDAPIGTYTVPITLYASWNNGDAEISTCPLKINVIAPQVELTKTLIDGNTTVHVKTNQSWTMRIEVTNYGSEKELVIRDVIPAELEVDLNRTSATNGTYTFTRQGIGNMGSTHMEWRVTVRKGESEYIDITVYTRLNPAGKQEFTSPGTYTLNEGAEIAGYGIKTDPITVEAVKEEDCCHHGGGCDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL89</accession>
    <name>F0LL89_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Reverse gyrase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Helicase</fullName>
                <ecNumber evidence="14">3.6.4.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">Topoisomerase</fullName>
                <ecNumber evidence="14">5.6.2.2</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">rgy</name>
        <name evidence="20" type="ordered locus">TERMP_00763</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14 15">Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 14">Monomer.</text>
    </comment>
    <comment type="domain">
        <text evidence="14">Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="14"/>
    <dbReference type="EC" id="5.6.2.2" evidence="14"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467038.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00763"/>
    <dbReference type="EnsemblBacteria" id="ADT83740">
        <property type="protein sequence ID" value="ADT83740"/>
        <property type="gene ID" value="TERMP_00763"/>
    </dbReference>
    <dbReference type="GeneID" id="10041081"/>
    <dbReference type="KEGG" id="tba:TERMP_00763"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.765"/>
    <dbReference type="eggNOG" id="arCOG01526">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002886_0_0_2"/>
    <dbReference type="OMA" id="GVATYYG"/>
    <dbReference type="OrthoDB" id="1837at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03361">
        <property type="entry name" value="TOPRIM_TopoIA_RevGyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01125">
        <property type="entry name" value="Reverse_gyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005736">
        <property type="entry name" value="Reverse_gyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034142">
        <property type="entry name" value="TOPRIM_RevGyr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040569">
        <property type="entry name" value="Znf_Rg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43505">
        <property type="entry name" value="PTHR43505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17915">
        <property type="entry name" value="zf_Rg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01054">
        <property type="entry name" value="rgy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 14 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 14 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 14 15" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="93"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="18">
        <location>
            <begin position="641"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type 1" evidence="14">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type 2" evidence="14">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Topoisomerase I" evidence="14">
        <location>
            <begin position="647"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1182"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="active site" description="For DNA cleavage activity" evidence="14">
        <location>
            <position position="957"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ADT83740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1216" mass="141474" checksum="B1BA410A831F4A5E" modified="2011-05-03" version="1">MKAIYREMCPNCEDRISDERLYKKHPCDVCLDREIQAEIYFDLITGIREALKLRRTLKHWENIYKLEKKLREIEDLFEKATGFNFWSAQKTWVKRLIKNKSFSIIAPTGMGKSVFGSFMALYYAKKKKKSYIVLPTTPLVVQTIKRVKTFAERAGIEINLAYYHGGMKKKEKEEMTEKIMSGDFDILITSAQWLARNFDEMLKDKRFDFIFVDDVDAFLKASKNIDRSLILLGFTEEIIQKAWEIIRLKKQMAKFLNGNSPDKQEQLKELNKQINKLEREIRKFKRENKIGVLIVASATGSARGDRIKLYRELLDFEVGSGRSALRNVVDSYLFPEKSIEEHVEELLTKLGKGGLIFVPIDQGISYAEKLTQYLQEKGFKVELVSARNKKGLEKFENEEIDYLVGVATYYGTIVRGLDLPHLIRYAIFTGVPKFRFSLDLEQPTIYRVLGLMSEVMEFLDEEDRREGERLYARLRRLIRNIPQFELMKIEEALAEGLPLEGFHSHVLEVFKQSVEFLRRVLKKEEVLKRIEEDPFVSLKEEEGKWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDNEKVFNGLKRQMRWRFAEFEMKPFEELNLEELLREIDSDREKVRLILAGKISEKTKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGDRMLTILASGGHMFDLVTTEGYHGVLIEERDGKLYFIPVYDTIKRCRDCGHQFVDWEERGVCPRCGSRNVRDALENVIAMREIAQEVDEILIGTDPDVEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKALNEARDVNEFRVNAQLVRRIEDRWIGFELSQKLWEVFESRNLSAGRVQTPVLGWVIQRYKEFVESETDFMALTLENGLSVTLEGVKDEVNEIIVEDVQIEEKEINPFPPYTTDTMLQDASRFLGFSAPHTMQLAQDLFELGLITYHRTDSTHVSNTGIEVAKEYISEEIGEEYFAPRKWGEEGAHECIRPTRPIDTGRLMQLLRDGIITLARGLTRDHFRLYDMIFKRFMASQMKAAKVLYEKAVIDARIAKTEIEGYVEIIFDGWTKLRAPPLKQLPRLEKGQKLKVIEVKKWRAPKVSLYTQGDLIALMKERKIGRPSTYAKIVKTLLDRHYVIETKGRKKLVPTELGTKVYHYLISKYKELVSEERTRQLEELMDLVEENKADYQEVLSNMYEEIKQYILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLF9</accession>
    <name>F0LLF9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP-dependent dephospho-CoA kinase</fullName>
            <ecNumber evidence="3">2.7.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Dephospho-coenzyme A kinase</fullName>
            <shortName evidence="3">DPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_02014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3'-dephospho-CoA + GTP = CoA + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61156"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP-dependent DPCK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468284.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02014"/>
    <dbReference type="EnsemblBacteria" id="ADT84988">
        <property type="protein sequence ID" value="ADT84988"/>
        <property type="gene ID" value="TERMP_02014"/>
    </dbReference>
    <dbReference type="GeneID" id="26137622"/>
    <dbReference type="KEGG" id="tba:TERMP_02014"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2011"/>
    <dbReference type="eggNOG" id="arCOG04076">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120795_1_0_2"/>
    <dbReference type="OMA" id="AIYDHKT"/>
    <dbReference type="OrthoDB" id="116732at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00590">
        <property type="entry name" value="Dephospho_CoA_kinase_GTP_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007164">
        <property type="entry name" value="GTP-dep_dephospho-CoA_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40732">
        <property type="entry name" value="PTHR40732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04019">
        <property type="entry name" value="DUF359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006533">
        <property type="entry name" value="UCP006533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="180" mass="20280" checksum="9F20CF02B3D2DA43" modified="2011-05-03" version="1">MCREFYFKLPFSLRSELKKPLGELVRGELPRPYILVKEKLEKAPYLITVGDVVTENVLKLGIKPSVAIYDHKTERNEYNPEIEFGAVILTANNPPATITKALLNAIRKSIELAKRGLNVYIKVHGEEDLAAIPAVLYAPFNALVVYGQPKEGIVLIKVTPECKRRCAEILRKMEVVYDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLG7</accession>
    <name>F0LLG7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468292.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02022"/>
    <dbReference type="EnsemblBacteria" id="ADT84996">
        <property type="protein sequence ID" value="ADT84996"/>
        <property type="gene ID" value="TERMP_02022"/>
    </dbReference>
    <dbReference type="GeneID" id="26137630"/>
    <dbReference type="KEGG" id="tba:TERMP_02022"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2019"/>
    <dbReference type="eggNOG" id="arCOG05790">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1313180_0_0_2"/>
    <dbReference type="OMA" id="AFDFYNP"/>
    <dbReference type="OrthoDB" id="85935at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="210" mass="24721" checksum="9A1CF4738F699200" modified="2011-05-03" version="1">MSDVVKDSVEVALELNEKEVYSHIAHESAEDIIRIISSLDAERAKNRGEVIYYQDDWDDLIRQRIQKGKRHTAFDFYNPALLNIWEAKVKYLKKVRNYVKLAMLGILAFLAVTIILSFFFDTPWFLVGVSALPLLIFFHSYRKEKLDFAYYQLTQFFIDELRELVLKHQLDSTRYKFKIFSYDYFGILTRKIGSSIFAIVKTGENMTNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLH1</accession>
    <name>F0LLH1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468296.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02026"/>
    <dbReference type="EnsemblBacteria" id="ADT85000">
        <property type="protein sequence ID" value="ADT85000"/>
        <property type="gene ID" value="TERMP_02026"/>
    </dbReference>
    <dbReference type="GeneID" id="10042341"/>
    <dbReference type="KEGG" id="tba:TERMP_02026"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2023"/>
    <dbReference type="eggNOG" id="arCOG05788">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034624_0_0_2"/>
    <dbReference type="OMA" id="KLWVWDD"/>
    <dbReference type="OrthoDB" id="101060at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="465" mass="51023" checksum="7DF9C8189964735B" modified="2011-05-03" version="1">MRRGQLLSIDALLSLVIVVMVVGVVINTNDMIKAEITNLVEWYDRANVANNMLDILTKSPGYPKDWDITNAPIRVLGLVSSNYPPSLAYNKILGLKERIQDGDPSVIDSLRNLSSGNDFMFEIYLRKYSISTSGFPITGIYIIVGAPNNNVNFRLSDSGNSPFDVVCGSVTLNGEPLSSSAGNILLDLTPGDVVEFIPLETVYVYSRGSLLGTIPPNAVVTVEVIDVGSNLQLRYNAATCQLQFTGIGRVYVQVKAYAPQDVNLTYDFTPVSNVTEPVLRIIMINGTIYAPNGTLYTYNDALSSMNNSQWIEVAERSLSMVKKVYKSNLTLTSAFSGVEPIIIGKLKLEIPNYAYLNVTLIGTEANASFLAVNGDSIVGVFAYKSGNITEAVIVENGTIVKKYSGSKGNVMIPLKDIFPEVNIAELYITSFEGTELFINTTWNLGVILEPRVESCRLKLWVWDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLH8</accession>
    <name>F0LLH8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purF</name>
        <name evidence="11" type="ordered locus">TERMP_02033</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468303.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02033"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="EnsemblBacteria" id="ADT85007">
        <property type="protein sequence ID" value="ADT85007"/>
        <property type="gene ID" value="TERMP_02033"/>
    </dbReference>
    <dbReference type="GeneID" id="10042348"/>
    <dbReference type="KEGG" id="tba:TERMP_02033"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2030"/>
    <dbReference type="eggNOG" id="arCOG00093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_3_1_2"/>
    <dbReference type="OMA" id="ENAQPTF"/>
    <dbReference type="OrthoDB" id="37299at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="5"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT85007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="442" mass="50041" checksum="1C0A8A45978260FB" modified="2011-05-03" version="1">MKEKCGIFAAKTENASRKAYYALLALQHRGQESAGISVWRNKIRTYKGLGLVAEVFRGHILNKLRSNISIGHVRYSTFGGLNEAHPLEVECCGKRLALVHNGTLTNYLPLRRKYEGEFEFKTSIDSELLGLIFLKNYSETKDEFEAMRMLFNEVKGAYSLAFLFDGKILVARDPLGFRPLAFGIGDGYYFASEDSALRMFDVETRDVKPGEVFVVSDDVENRVLTKKKHAHCVFEFIYFARPDSVIEGRTVYKARVEMGKQLAREDNINADIVIAVPDSGRAAAIGYSMESGIPYEEGLIKNRYIGRTFIMPTQFEREFKVRLKLSPVKEVIKDKRIILIDDSIVRGTTMKRIVAMLKKAGAKEVHVRIASPPIRYPCYMGIDIPTRHELIASWKSVKEIGKEIGADSLRYLSIEGLINAVELDDLCLACLNGIYPEWAFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLJ0</accession>
    <name>F0LLJ0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="6">IMP dehydrogenase</shortName>
            <shortName evidence="6">IMPD</shortName>
            <shortName evidence="6">IMPDH</shortName>
            <ecNumber evidence="6 12">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">guaB</name>
        <name evidence="14" type="ordered locus">TERMP_02045</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 12">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 12">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 11">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="6 12"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468315.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02045"/>
    <dbReference type="EnsemblBacteria" id="ADT85019">
        <property type="protein sequence ID" value="ADT85019"/>
        <property type="gene ID" value="TERMP_02045"/>
    </dbReference>
    <dbReference type="GeneID" id="10042360"/>
    <dbReference type="KEGG" id="tba:TERMP_02045"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2042"/>
    <dbReference type="eggNOG" id="arCOG00612">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_2_1_2"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="OrthoDB" id="58700at2157"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 12" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 12" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="6 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="99"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="156"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="6">
        <location>
            <begin position="334"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="6">
        <location>
            <begin position="357"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="6">
        <location>
            <begin position="381"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="6 7">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="247"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <begin position="294"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADT85019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="485" mass="52351" checksum="4DABB6CF5840E232" modified="2011-05-03" version="1">MGKFEQKFVNAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNIKLNIPILSAAMDTVTEWEMAVAMAREGGLGVIHRNMSIGEQVEMVKKVKKAERFIIEDVITISPDETLDYALFLMEKHDIDGLPVIKDGKVVGIVSKKDIAAKEGQKVKDIMTKEVITVEEDISVEEAMKIMVKNRIDRLPVVNKKGKLIGLITMSDLVLRKKFKNAVRDENGDLLVAAAVGPFDLKRALALDRAGADVIVIDTAHAHNLKAIKSMKEIRAKVDADLIVGNIANPKAVDDLTFADAIKVGIGPGSICTTRVVAGVGVPQITAIALVADRAGEYGIKVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGHMKTRKFVPEGVEGVVPYKGSVSEVLYQLIGGLRAGMGYVGAKNIQELKEKGEFVIITHAGLRESHPHDIFITNEAPNYPVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLM0</accession>
    <name>F0LLM0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467095.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00820"/>
    <dbReference type="EnsemblBacteria" id="ADT83797">
        <property type="protein sequence ID" value="ADT83797"/>
        <property type="gene ID" value="TERMP_00820"/>
    </dbReference>
    <dbReference type="GeneID" id="26136272"/>
    <dbReference type="KEGG" id="tba:TERMP_00820"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.822"/>
    <dbReference type="eggNOG" id="arCOG01141">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_3_2_2"/>
    <dbReference type="OMA" id="ADTHVPK"/>
    <dbReference type="OrthoDB" id="80065at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="172" mass="19954" checksum="D28DB3FE208FE98C" modified="2011-05-03" version="1">MVRIGILSDTHYPDKTSYLPNLIFEKFQEENVELIIHAGDLTSPSVKEVLENVAPVVAVRGNLDEPIFPEERILEVEELKIGIIHGHQFLSLDTQTLKYKALDMEVDILIFGHTHRFFYEVYEFMGKKIALLNPGSPTVPRRSDPTFVIAEIKDRNLNFNIFKPWKTQWQYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLP5</accession>
    <name>F0LLP5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467120.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00845"/>
    <dbReference type="EnsemblBacteria" id="ADT83822">
        <property type="protein sequence ID" value="ADT83822"/>
        <property type="gene ID" value="TERMP_00845"/>
    </dbReference>
    <dbReference type="GeneID" id="10041163"/>
    <dbReference type="KEGG" id="tba:TERMP_00845"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.848"/>
    <dbReference type="eggNOG" id="arCOG00509">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017490_0_0_2"/>
    <dbReference type="OMA" id="AFGLHYC"/>
    <dbReference type="OrthoDB" id="72715at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="248"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="393" mass="44143" checksum="49C14DB9261DD25C" modified="2011-05-03" version="1">MKAVKIVEDVYWVGVKDWNRRIFDSLIPLPEGTSYNAYLVVGREKTALIDTVNPGFERELEEKINEIVDVADIDYIVMNHAEPDHSGAIPYLLERNKKVILIATEKGANMAKAYYDVPDERIMVVKDGDTVSLGGKTLRFIEAPWLHWPETMFTYLVEDKILFPCDFFGAHLAGGFYDDDVPDLLTHAQRYFGEIMMPFSAMAKKALKKIEGLEIKIIAPSHGPIYRNPRRIIEAYKKWSSGETKEKVIIAYVSMWGANETMVRELAALLTAEGIDVKVYNLVSSDIGEIAKDLVDSRVIVLAAPTVLGGAHPLAIYAAYLVKALRPPAKYAVIMGSYGWHGRSKDSLLEVLKGSNIELLGSLEVRARPKNEDYEKLRRLALLIQEKVRGDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLT5</accession>
    <name>F0LLT5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467160.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00885"/>
    <dbReference type="EnsemblBacteria" id="ADT83862">
        <property type="protein sequence ID" value="ADT83862"/>
        <property type="gene ID" value="TERMP_00885"/>
    </dbReference>
    <dbReference type="GeneID" id="10041203"/>
    <dbReference type="KEGG" id="tba:TERMP_00885"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.888"/>
    <dbReference type="eggNOG" id="arCOG00895">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_9_0_2"/>
    <dbReference type="OMA" id="MVNTDAV"/>
    <dbReference type="OrthoDB" id="17570at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="238" mass="27557" checksum="2517FC552CC5E9AD" modified="2011-05-03" version="1">MKFSLIIPAYNEEKRILRTLNEYYAALKATFNEDFEIIIEMDGCTDRTPQVVRNFAQDKENVKILEFPKRLGKGGGLLQAFKVAKGEIIGFTDADGSTPAKEYIRLIRTINKGYDVIIGSRWLPESKVTIPQPLIRRILSRGFNLLVRLLFNLNIRDTQCGAKVFRREVIESAIPYIKIGGFAFDVELLYIAKTMGFKIKEEPIEWHNEKESKLNLKSVVPRMFIDIIKLRIRTIRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLT8</accession>
    <name>F0LLT8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467163.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00888"/>
    <dbReference type="EnsemblBacteria" id="ADT83865">
        <property type="protein sequence ID" value="ADT83865"/>
        <property type="gene ID" value="TERMP_00888"/>
    </dbReference>
    <dbReference type="GeneID" id="10041206"/>
    <dbReference type="KEGG" id="tba:TERMP_00888"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.891"/>
    <dbReference type="eggNOG" id="arCOG03812">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043492_0_0_2"/>
    <dbReference type="OMA" id="FQSTAFE"/>
    <dbReference type="OrthoDB" id="36364at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018650">
        <property type="entry name" value="STSV1_Orf64"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09852">
        <property type="entry name" value="DUF2079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="489" mass="57289" checksum="3711099147763684" modified="2011-05-03" version="1">MSENSTKDRKKVAKYILICAFIFILQLIYSILRYHVFFTSAFDLGIYIRKISHYGAKRIAFLGHSEPILLLILPLYELFPYAETLLILQALSVALSGLIFYKFANEILKNRDISFGLMLLYFLNPFLLGLIRYDFHPVSLALPFIFLTAYYLEKRKYKKALIASLFILSVKEDAGIALVSLGSYYLLKSNNFSLKVTIKKGLKLRFKREEWPLIILTLLGILWILLSIFILIPHYSARRHYGYTNRYSNPLSYLPEKIAYILLHGVFVGFIPYTFPPNIFLFGVPMLENLLSSRIYQIAIGYQYQYMVVPLLFIATTYAIKIKKLDWESIKKIILTSLLISVLFSPLIPPYGIEEYFPILYKDPRFPIPSEHDRMLKNVIDIISVTNLTVLPQPTIYPHMANRKETYLFYNQTNPPDILLLDPYIPLYCIQKDDTWCYDVHYFFELFNISKKYKLYTFKGIEIYVRYDKVNSDNIQKLLAKIRQVTSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLU3</accession>
    <name>F0LLU3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468338.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02068"/>
    <dbReference type="EnsemblBacteria" id="ADT85042">
        <property type="protein sequence ID" value="ADT85042"/>
        <property type="gene ID" value="TERMP_02068"/>
    </dbReference>
    <dbReference type="GeneID" id="10042383"/>
    <dbReference type="KEGG" id="tba:TERMP_02068"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2065"/>
    <dbReference type="eggNOG" id="arCOG00719">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2230512_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="105" mass="11895" checksum="4014B0C00E53DB9E" modified="2011-05-03" version="1">MLSNFAKVGKLELLKDILRDSIITKQILEEFNLGIERGILALSVKTGVLTPGEADQILRTMIKSVFYSPIESLEGVLKGNTPQPRIDFYGLYTIEVYEKKIRHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLV0</accession>
    <name>F0LLV0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468345.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02075"/>
    <dbReference type="EnsemblBacteria" id="ADT85049">
        <property type="protein sequence ID" value="ADT85049"/>
        <property type="gene ID" value="TERMP_02075"/>
    </dbReference>
    <dbReference type="GeneID" id="26137685"/>
    <dbReference type="KEGG" id="tba:TERMP_02075"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2072"/>
    <dbReference type="eggNOG" id="arCOG02217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175270_0_0_2"/>
    <dbReference type="OMA" id="RVNWAEE"/>
    <dbReference type="OrthoDB" id="131018at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039709">
        <property type="entry name" value="VapB3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42244">
        <property type="entry name" value="PTHR42244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="76" mass="8971" checksum="4495AC03F1C3B58A" modified="2011-05-03" version="1">MGNVISIRVPPEIKHEMDKLKGEVNWSEEIREFIKKRIKEYKKRKALQEVIAYIQTLPEAPKGTAQKLVREDRDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLW7</accession>
    <name>F0LLW7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468362.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02092"/>
    <dbReference type="EnsemblBacteria" id="ADT85066">
        <property type="protein sequence ID" value="ADT85066"/>
        <property type="gene ID" value="TERMP_02092"/>
    </dbReference>
    <dbReference type="GeneID" id="10042407"/>
    <dbReference type="KEGG" id="tba:TERMP_02092"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2089"/>
    <dbReference type="eggNOG" id="arCOG01377">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024306_0_0_2"/>
    <dbReference type="OMA" id="HPRIHET"/>
    <dbReference type="OrthoDB" id="6644at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="477" mass="55805" checksum="B122E0E3147AA6AE" modified="2011-05-03" version="1">MRNKKYRIAIIGLDGANKTTSKLIGIKSQLHDFVSTIPPYTPPAWTSIVTGVNPAKHGIIDFLKIDPRNFKSKLTTSYDVRYPRISEFLDVYGLRSILINLPMSYPFDGFRFRDNTIIVSDWAAPRQEIYPKKIKEKYNEYLIDPPHSWEKHKNNSREYAKLVEEFTNTRLTLYYELLEKHSWDLYFLVFSETDWFSHIFPQILEGKDTHLVSPVFRKIKKFIHDARDIADITFIVSDHGFEIKRKIFYVNQALARSGFIEYNEFKASLIRLGRRMLPPKIAKILMKKGITQMSHASNSQRRKAFFASHNTWGVYTTENSIKEQVKRALNSFPEISKVVSTEEIYTGPYLHLLPDLFIIPKKGVELSAELKRRLVEPIYKGDHEIHGVFSTYGEHIKDSIKFERLPRVYDIVPTILHIFGLPIPNDMDGRVLMEIFEEDSEFAKRKPKYVDPSYYEKNQEDEKLKKAIKNLKLKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLW9</accession>
    <name>F0LLW9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02094"/>
    <dbReference type="EnsemblBacteria" id="ADT85068">
        <property type="protein sequence ID" value="ADT85068"/>
        <property type="gene ID" value="TERMP_02094"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02094"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2091"/>
    <dbReference type="eggNOG" id="arCOG01403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_5_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="189"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="378" mass="43187" checksum="6D515D5CE49A62A0" modified="2011-05-03" version="1">MKVLLIVRNVLHPHDGPSSASYNTIKGLKTFQKVLEKNEISIDILSLDTTDNRSVDVSELESPNLNIINVKSIPLEAVFGEIYCVKMYSNKLHNTHNLVHSHVPFGAFFGIFNRLPTLLTVHGMVWKERKHITNKYAKVAYGYGNTFRIRKYADKVSKLIALSPYAKEEFISLGVDPDKIAIIENPISEEFFKVKKNEENIILYPANIIPLKNQLGFLRAVKLVENEVRDFKIIFAGSGDSNYIRILKDFVRRNEIRNVKFLGRVRYKQMLTLYSNASITVLLSFQETLPMVILEAMATGTPTLVSKILPNRYIVTPNKTGVLADPNNPENIAEKLRILIDDKKLRQKLGKNAKKEAEKRWKSKVIARKLLDLYLTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLX9</accession>
    <name>F0LLX9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02104"/>
    <dbReference type="EnsemblBacteria" id="ADT85078">
        <property type="protein sequence ID" value="ADT85078"/>
        <property type="gene ID" value="TERMP_02104"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02104"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2101"/>
    <dbReference type="eggNOG" id="arCOG11267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3338672_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="37" mass="4399" checksum="00CFD2512515DE5C" modified="2011-05-03" version="1">MINELKKKKYILERTFGLAKTKKSAKELRAEIYDDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM14</accession>
    <name>F0LM14_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hydro_57 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468409.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02139"/>
    <dbReference type="EnsemblBacteria" id="ADT85113">
        <property type="protein sequence ID" value="ADT85113"/>
        <property type="gene ID" value="TERMP_02139"/>
    </dbReference>
    <dbReference type="GeneID" id="10042454"/>
    <dbReference type="KEGG" id="tba:TERMP_02139"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2136"/>
    <dbReference type="eggNOG" id="arCOG03282">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473827_0_0_2"/>
    <dbReference type="OMA" id="HFHAYQP"/>
    <dbReference type="OrthoDB" id="4751at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="1">
        <location>
            <begin position="91"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="596" mass="69686" checksum="F06B10D6090FCEE8" modified="2011-05-03" version="1">MFQKFGYHFHAYQPGDIIYIHDGSGWDPIKYSERLSPVSLEIRDIEVKGRNWTRAVIKAYEYVDDTLLLLRKNSVSVDFEPFTLYMILEHKPKIYSQIVETLQNHVEVVPTVPFHPIMPHLSIFEQEILAKVSFDFYEPFIRDKSIVGFWLPENVITRKTAGIITEATEKKVVFLLDERQFIGLNIPQAKYSCNTYKCDGKTAFVFGRDHQLSDAFAFNTLDAEGLIRAVSEGRIDVFKENSGIPYLVFLSSDLEALLSNPQQLDKFLKWIKGLEERGVEAVNAVEFVRKKVSGEYRCLHGECSEQFKINVKDYSSWSDYYDLSIDGRTGDMRWTGVRREDNKVIHRWYKGEKVSQLWKFAFTKLFRELNRAVRFGVMDLIKKYSRADSNSIKEFLVRYARIFFREHYEYFDMDTSVDYVTEPVKDADPALTLKLGRIYYIMLLANHSCPRFWENIDTRVTFGNVIAISKALIELIELYMEENSERANFLLLEYMKLLAFPQLYYDYDLFRMKGLEGWETSEEAWFASLKSEVPNSRYNVVTRAALYAAKEDLPRDIRSAIESLYDLKQAVADTGHIPGEVHGRWENKEWCEHRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM46</accession>
    <name>F0LM46_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA double-strand break repair protein Mre11</fullName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mre11</name>
        <name evidence="8" type="ordered locus">TERMP_00917</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Nuclease activity is regulated by Rad50.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467191.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00917"/>
    <dbReference type="EnsemblBacteria" id="ADT83893">
        <property type="protein sequence ID" value="ADT83893"/>
        <property type="gene ID" value="TERMP_00917"/>
    </dbReference>
    <dbReference type="GeneID" id="10041234"/>
    <dbReference type="KEGG" id="tba:TERMP_00917"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.918"/>
    <dbReference type="eggNOG" id="arCOG00397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026621_5_1_2"/>
    <dbReference type="OMA" id="RWDFGDY"/>
    <dbReference type="OrthoDB" id="25870at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02044">
        <property type="entry name" value="Mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032885">
        <property type="entry name" value="Mre11_archaea-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="7">
        <location>
            <begin position="3"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="443" mass="51747" checksum="8A80809F1F09E465" modified="2011-05-03" version="1">MTFKFAHIADVHLGFEQYRLPYRAEEFREAFETAIKKAVEEKVDFILIAGDLFHRSNPSPQTIKDAIDILSIPKEDNIPVFAVEGNHDRTQKKISAYHLLESLGLIHLLGFSEEKKENEYQTTEKVNGKLIVKGVFEKGNKSIEIYGMKFMSAAWFERNKLSDYFKPDGDAILMLHQGIKEMMDKLYLETQRDYFEITLEDLPDGFLYYAMGHIHKRWQTSKGLGIVAYPGSLQRWDFGDYEIRYRWDGNKFSLQAGEDKGFLIVEDFKPRFIKLDVRPFYDIRIKANESVARRELKRLVAKIPNEAFLRVHIEWEKPFDVSFLHDVFKVRYLHIRTKFGKASLLKAKGTTASEFFTPMELKVIERVGEKDFEEFDEIIKLILEGIEDSTNADKKVVEKEETEEKLQKTEPRAEREIKVQKAEKKVKKAPPKKKSDILAWLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM52</accession>
    <name>F0LM52_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">8-amino-7-ketopelargonate synthase</fullName>
            <ecNumber evidence="7">2.3.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_00923</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42288"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78846"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="EC" id="2.3.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47" evidence="7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467197.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00923"/>
    <dbReference type="EnsemblBacteria" id="ADT83899">
        <property type="protein sequence ID" value="ADT83899"/>
        <property type="gene ID" value="TERMP_00923"/>
    </dbReference>
    <dbReference type="GeneID" id="10041240"/>
    <dbReference type="KEGG" id="tba:TERMP_00923"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.924"/>
    <dbReference type="eggNOG" id="arCOG00113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_0_2"/>
    <dbReference type="OMA" id="MDTHGFG"/>
    <dbReference type="OrthoDB" id="39668at2157"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010962">
        <property type="entry name" value="AONS_Archaea/Firmicutes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004723">
        <property type="entry name" value="AONS_Archaea/Proteobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00858">
        <property type="entry name" value="bioF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01825">
        <property type="entry name" value="gly_Cac_T_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="8">
        <location>
            <begin position="39"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604723-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="395" mass="43963" checksum="17C8E1EA39F2B7EE" modified="2011-05-03" version="1">MGKLDWITEELNELKEKGLYVRIRVLQSAQGPWVVVDGKKVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALITKKDNGVFISEELNHASIIDGMRLSGAPKVIYKHLDMEDLKKKLEETKNYKKKLIVTDGVFSMDGDLAPLPEIVELAEQYDAMVYVDDAHGEGVLGDHGRGIVDHYKLHDRVDFEMGTLSKAFGVIGGYVAGSEEAIEYLKQRGRPFLFSSALNPPDVAAAIAAVEILQHSDELVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHSKEDLQYVIDAFEDLGKKTGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM66</accession>
    <name>F0LM66_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="2">RPPK</shortName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="2">P-Rib-PP synthase</shortName>
            <shortName evidence="2">PRPP synthase</shortName>
            <shortName evidence="2">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prs</name>
        <name evidence="6" type="ordered locus">TERMP_00937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467211.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00937"/>
    <dbReference type="EnsemblBacteria" id="ADT83913">
        <property type="protein sequence ID" value="ADT83913"/>
        <property type="gene ID" value="TERMP_00937"/>
    </dbReference>
    <dbReference type="GeneID" id="26136382"/>
    <dbReference type="KEGG" id="tba:TERMP_00937"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.938"/>
    <dbReference type="eggNOG" id="arCOG00067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_2_2_2"/>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="OrthoDB" id="59314at2157"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_A">
        <property type="entry name" value="RibP_PPkinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037514">
        <property type="entry name" value="Rib-P_diPkinase_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="144"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="2">
        <location>
            <begin position="218"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="37"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="94"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="284" mass="31553" checksum="D74D6F57EB8B9556" modified="2011-05-03" version="1">MKVVLGSGAQHLKEEIRRKVQNYGKELLEVEIKKFPDGEKYVRVPGEGNRVIVVQSTHFPQDEHIIELLLLGDALKEKGFEKLIAVVPYLAYSRQDRVTKDGEPISVRAVMKTMGIYYDELYVFDLHNPKTLEFFPGKAVNLSPARAIADYFKDKLGEGIVLAPDKGALERAKAVAEILNVEFSHFEKKRISPTEVQMTPVDIDVTGKNVLIVDDIISTGGTMIRAANILRRMGAKKIYVVATHGVFAEGAIERVSRAVDELAVTNTIPTPVSKISIVKDILTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM68</accession>
    <name>F0LM68_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467213.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00939"/>
    <dbReference type="EnsemblBacteria" id="ADT83915">
        <property type="protein sequence ID" value="ADT83915"/>
        <property type="gene ID" value="TERMP_00939"/>
    </dbReference>
    <dbReference type="GeneID" id="10041256"/>
    <dbReference type="KEGG" id="tba:TERMP_00939"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.942"/>
    <dbReference type="eggNOG" id="arCOG04875">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113977_0_0_2"/>
    <dbReference type="OMA" id="FIIEHFD"/>
    <dbReference type="OrthoDB" id="71402at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007162">
        <property type="entry name" value="DUF366"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04017">
        <property type="entry name" value="DUF366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006503">
        <property type="entry name" value="UCP006503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="188" mass="21265" checksum="7F42CB47481B3356" modified="2011-05-03" version="1">MELLVIKDKRIDYDGSAIRSHWAYRNFGILGNSIVVFRGKCNVKVEEMIDIEDARAQKEIKSDDMIHYIIEIFAFPNVLLASALQKLFIAKICEFLSEYGVKTKRKGDDIYVEDKKLSISIATVSPVSIKIHIGINVEAKGTPKDVNAIGLREIGIGDIETFMEKSGKALQEEFNKVKKDSLKVRWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM74</accession>
    <name>F0LM74_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoaspartyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467219.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00945"/>
    <dbReference type="EnsemblBacteria" id="ADT83921">
        <property type="protein sequence ID" value="ADT83921"/>
        <property type="gene ID" value="TERMP_00945"/>
    </dbReference>
    <dbReference type="GeneID" id="10041262"/>
    <dbReference type="KEGG" id="tba:TERMP_00945"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.948"/>
    <dbReference type="eggNOG" id="arCOG04779">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_1_2_2"/>
    <dbReference type="OMA" id="YSRMRWK"/>
    <dbReference type="OrthoDB" id="66502at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="203"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="225"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="306" mass="32825" checksum="2EF6A7D6FB38E643" modified="2011-05-03" version="1">MVAIIVHGGAGTIKNEEKIPKAIKGVREAVLAGWKELKRGSALDAVEEAVKALEDNPIFNAGTGSVLTLDGRIEMDAAIMRGKTLEAGAVASIWGIKNPISVARKVMEKTDHVLLVGEGALKFARIMGFDEYDPITEERREQWKKLREKLLKEGTIPYWKKISELIKEHPEVLRSTVGAVAFDGEEVVAGTSTGGVFLKMFGRVGDTPIIGAGTYANELAGASCTGLGEVAIKLSLAKTAVDFVRLGLSAQKASEAAIEMATKYFGKDTMGIIMVDREGNVGFAKNTKHMSVAYLKDGMNEPFAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM75</accession>
    <name>F0LM75_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467220.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00946"/>
    <dbReference type="EnsemblBacteria" id="ADT83922">
        <property type="protein sequence ID" value="ADT83922"/>
        <property type="gene ID" value="TERMP_00946"/>
    </dbReference>
    <dbReference type="GeneID" id="26136395"/>
    <dbReference type="KEGG" id="tba:TERMP_00946"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.949"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_10_13_2"/>
    <dbReference type="OMA" id="TMFFDLG"/>
    <dbReference type="OrthoDB" id="22281at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="401" mass="43620" checksum="3E3307A9C99AA07B" modified="2011-05-03" version="1">MRTKDFPGDIWILHLSTFFFFLGIALVSPLISPLAILLGATPLIVGSIASVSSIVSFFLKPLGGFLGDRGWKFQVMMLGSGLGALAGVFYIASIPFGNLALFAVGRGIHGFAMALFFPSSLATAIELAPRGRVGETLGWRGMMFSFSNLIGPAIGGFVAEYLGFQAAFAFTVIVSLVALLFVFIAYKRDKNRIKTKREHKHEHVSYRLLLNSFFVAACFSLLFMSLAYSGTFTFLPALYKVLGLGTSAFGIYASIMGGFSLLTRVFGGREADRRGPIPVATFGFLLLLLAYIMLSLHPTPPLAYLSAIPLGMGFGFAVPSLQMMALAKLPQKIRTFGSSIYTMFFDLGYLAGPLVFGYIAQLKNSYEAVFPMFPLVTILSLIILQLPRFLKRDSQSKKGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LME8</accession>
    <name>F0LME8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NiFe hydrogenase metallocenter assembly HypC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468467.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02197"/>
    <dbReference type="EnsemblBacteria" id="ADT85171">
        <property type="protein sequence ID" value="ADT85171"/>
        <property type="gene ID" value="TERMP_02197"/>
    </dbReference>
    <dbReference type="GeneID" id="26137832"/>
    <dbReference type="KEGG" id="tba:TERMP_02197"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2192"/>
    <dbReference type="eggNOG" id="arCOG04427">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159381_2_2_2"/>
    <dbReference type="OMA" id="MCLAIPC"/>
    <dbReference type="OrthoDB" id="119258at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019812">
        <property type="entry name" value="Hydgase_assmbl_chp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01097">
        <property type="entry name" value="HUPF_HYPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="74" mass="8195" checksum="F68FF2A0BF84A9B4" modified="2011-05-03" version="1">MCLAVPAKVLEIKGKVAIVDFGGVKREARLDLLPNVEVGDYVIVHTGFAIEKLDDKTAKEILQAWEEVLKAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMF1</accession>
    <name>F0LMF1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_02200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468470.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02200"/>
    <dbReference type="EnsemblBacteria" id="ADT85174">
        <property type="protein sequence ID" value="ADT85174"/>
        <property type="gene ID" value="TERMP_02200"/>
    </dbReference>
    <dbReference type="GeneID" id="10042515"/>
    <dbReference type="KEGG" id="tba:TERMP_02200"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2195"/>
    <dbReference type="eggNOG" id="arCOG00198">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_2"/>
    <dbReference type="OMA" id="KALCQEI"/>
    <dbReference type="OrthoDB" id="68573at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT85174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="256" mass="28606" checksum="C5AD13AC3549EC08" modified="2011-05-03" version="1">MLEVKGLSFSYGDFSVEDICFEVKEGEILTLLGPNGSGKTTILKSIYGLLKPKKKCVFVDGKDFHSLSLKERAKLAGYVPQSHHPSFPYTVLDVVVMGLASQLGVFESPRKEHYQKALEKLKLIGMERFKDKPYTQLSGGQLQLVLIARALVQEPKVLLLDEPTAHLDFKNQVKVLGIVKRLAKEESISAVMTLHDPNLASLYSDRIALVKEGRIRALGKPTQILREEVLEEVYGVPICILEFNGFRLILPKMEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMF3</accession>
    <name>F0LMF3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CobN-like cobalt chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468472.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02202"/>
    <dbReference type="EnsemblBacteria" id="ADT85176">
        <property type="protein sequence ID" value="ADT85176"/>
        <property type="gene ID" value="TERMP_02202"/>
    </dbReference>
    <dbReference type="GeneID" id="10042517"/>
    <dbReference type="KEGG" id="tba:TERMP_02202"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2197"/>
    <dbReference type="eggNOG" id="arCOG03022">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002017_1_2_2"/>
    <dbReference type="OMA" id="YQFQGGL"/>
    <dbReference type="OrthoDB" id="344at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051116">
        <property type="term" value="F:cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10150">
        <property type="entry name" value="CobN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011953">
        <property type="entry name" value="Cobalto_CobN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02257">
        <property type="entry name" value="cobalto_cobN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1252" mass="142441" checksum="426C42C886ABAA12" modified="2011-05-03" version="1">MICLIIGYGARALPLLQEILREEGIKGIVLTDQNCERELDKVETAGVIFVYAHELPEIVKEKIRDSKAKVIACAGLESLTNVPEEVVIKAKTYYVLGGEKNLRNLIRFLAGLTGKAIEYEEPEEVPMHGIYHPDFGVFESLDKYLEVYKKRPLVGVLFWRSAWLYKEFKPIGELIKALEEEGFGVIPVFTYGKDSTTGLGREKSEAVEEFFMRDGKPIIEALVSLISFGTVDLKNLQKLNVPVFAPVRSYYQSLEEWEKSEQGVDYMTQVYGVIIPEVAGAIEPIFIAGTRNIEGYKVGEPYEEHMKYLAKRVKKWVELRKKPKSEVKIAIVLINPPCKGLEANIGVGLGLDVPESIVRLLHRLKEEGYYVGEDLPKSGKELIKLILEKKAISEFRWTSVEDIVKSGGAVDFVGLEEYLEWFNELPDDLRERIIKDWGKPEDVLAGKVDKALVGMVYDGKFVVPGIRFGNVFITPQPKFGCAGARCDGKVCRILHDPKIVPPHQWWAVYRWITRKFKADVMIHFGTHGYLEFRPGKGVGLSPSCVPEASLDEVPHLYVYVVSNPMEGVIAKRRGYATLIDHMYPPMGMAEVLDDLDSLLTQYAKAKSLGDEARRKKIYEQILEKAKENKLRIANPEDEEQAIEEIHRYVELMRGSQINLGLHIFGHPPKEPERLAEYIATAMAYDSYASPSIRRVIAEAVGIDYDEIRKNPLGTTNSFTNRELLEIFHKIAVKSLECLLKGESFGVIEEEIEKFGFKLKNKEKLEETFRKALEVAEKIIECEKEYEGFLKGLSGEHVEPGPSGAITRGKFEILPTGRNFYAVDPRTLPTKAAWQIGVETAQKLLKAYKEKHGRYPESVGQVLWSIDGYKADGEQIAQILYLIGVRPVWKGDVVAGLEVIPLEELGRPRIDVLVRISGIVRDTLPNYIYLIDEAIEKVVMLDEPLEMNYIKKHYIEHIKKLIELGKSFEEAQRFARFRVFSAPPGAYGAGVNLAVESSGWKSEEDLAKVWVQWSGYAYGKDAFGVEAHESLVLNLKEVDVINRNHISDEHDPTNCCCYFAYHGGFKTAVDALTGKNIEVVQTDTRDISDAKIVDMKVELERVVRAKLLNERWIEEMKKHGYRGASEFSKKILHLYGWEATTKLVEDWVFDEIAQKYVLNEEMRRWFEEHNPYAIEEIARRLIEAYERGLWKTSDELIEKLMEVYSEIEGILEESLGEGEVQGGTIEIYTAEDDEHWNEKIEEVDKIWSLVKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMK9</accession>
    <name>F0LMK9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467286.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01012"/>
    <dbReference type="EnsemblBacteria" id="ADT83988">
        <property type="protein sequence ID" value="ADT83988"/>
        <property type="gene ID" value="TERMP_01012"/>
    </dbReference>
    <dbReference type="GeneID" id="10041329"/>
    <dbReference type="KEGG" id="tba:TERMP_01012"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1015"/>
    <dbReference type="eggNOG" id="arCOG04212">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114051_2_3_2"/>
    <dbReference type="OMA" id="DERFAHT"/>
    <dbReference type="OrthoDB" id="124564at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025707">
        <property type="entry name" value="DNA_bp_PD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016702">
        <property type="entry name" value="DNA_bp_PD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="140" mass="15683" checksum="265FA0C1ED14B8EA" modified="2011-05-03" version="1">MRFSRGRNFMFRIPEGEEFLTFINKFAEKNNVLIGTVAAIGTLRNPKIGYFEEEKGKYKVIELSGTYELLSALGNISLKDGKPFAHIHVALGDKEGRVLGGHLIEGEVFVAEVIIHELLGEPLERKVQENGLALWDAEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LML6</accession>
    <name>F0LML6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467293.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01019"/>
    <dbReference type="MEROPS" id="M55.A01"/>
    <dbReference type="EnsemblBacteria" id="ADT83995">
        <property type="protein sequence ID" value="ADT83995"/>
        <property type="gene ID" value="TERMP_01019"/>
    </dbReference>
    <dbReference type="GeneID" id="10041336"/>
    <dbReference type="KEGG" id="tba:TERMP_01019"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1022"/>
    <dbReference type="eggNOG" id="arCOG04080">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086038_1_0_2"/>
    <dbReference type="OMA" id="ATGVTWP"/>
    <dbReference type="OrthoDB" id="72758at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027476">
        <property type="entry name" value="DppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007035">
        <property type="entry name" value="Peptidase_M55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036177">
        <property type="entry name" value="Peptidase_M55_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04951">
        <property type="entry name" value="Peptidase_M55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015853">
        <property type="entry name" value="Pep_DppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63992">
        <property type="entry name" value="SSF63992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="280" mass="31104" checksum="543E5F48FE4D4218" modified="2011-05-03" version="1">MKAFISIDLEGMPFVVSREHLFVKGALYNEARKIATKTTLIAAEALHEKGFDEIIIADSHGPMVNLLVEELPEYVELVRGFPRPLSMVAFAKESDIAMFLGYHAKAGTPYATFDHTYSGAAVDYFEINGVKVSEFLLNSYLLGEWDIPVVLVGGDAKLIEGDVKEFTPWAEGVVFKNALSRYAAKSPSLARLEKEIREAVDRAVEKFKRGEAKPLKTEKPVKAKLRFLGSEMADAAELLPTVKRLDGKTVEFEAKNVEETYKLFELLVFAAAGVRAIVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMT7</accession>
    <name>F0LMT7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation initiation factor 6</fullName>
            <shortName evidence="3">aIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eif6</name>
        <name evidence="4" type="ordered locus">TERMP_01090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467364.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01090"/>
    <dbReference type="EnsemblBacteria" id="ADT84066">
        <property type="protein sequence ID" value="ADT84066"/>
        <property type="gene ID" value="TERMP_01090"/>
    </dbReference>
    <dbReference type="GeneID" id="10041407"/>
    <dbReference type="KEGG" id="tba:TERMP_01090"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1093"/>
    <dbReference type="eggNOG" id="arCOG04176">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071894_1_0_2"/>
    <dbReference type="OMA" id="GEDTTGP"/>
    <dbReference type="OrthoDB" id="70525at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="PTHR10784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="228" mass="25092" checksum="BA544AFF073BE24F" modified="2011-05-03" version="1">MHIERLDFENSPYLGVFGVATDKVLLVREGLQEKKLNVLREVLKVPIIETSIMKSRIVGIFAAGNSNAIVVPYYIWDTELERINAALREYDLDIRIEPFLSKLTALGNLILANDKAALVSAKFTREEAKQLEDILGVEVERGIIAEFHAVGSVGVVTNKGGLVHPETTEEELEWLRDLFKVDIYLGTANQGVPFVGSCMLANSFGVVVGHLTTGPEIVKIEEALGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMU3</accession>
    <name>F0LMU3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01096"/>
    <dbReference type="EnsemblBacteria" id="ADT84072">
        <property type="protein sequence ID" value="ADT84072"/>
        <property type="gene ID" value="TERMP_01096"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01096"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1099"/>
    <dbReference type="eggNOG" id="ENOG502N5P5">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498426_0_0_2"/>
    <dbReference type="OMA" id="MIFPNTT"/>
    <dbReference type="OrthoDB" id="45892at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="562" mass="64821" checksum="74B5B3C6BBC4968E" modified="2011-05-03" version="1">MKKFKEVIMENRKVVEKCMTVILLSMLLLSPVSAHSTAWCEDCHQVLVANEGLFAYNGSDFIDLTWHLEAGISDPLDIREFISNLGVTTVGDVVLVYSNYHDSIYMGIYNGSIPIRMKPVVGWYSWKPRDFVFYSGSVFFVAETGSGPHYASDSVFQLNPRTLKVEKTWSLAWNARNTIAPENAGNTPYAWVHLGLDDNGKLWAKVDMIFPNTTVYYLYDGTNFVMTNETPKLHPYEPPNGPFKIEIQRGLMYYLPKFPPVYVPTRYILIENDRRKDVTDEIKKLAESVEPLYSLIGFWNEDEKEWVVVYDLYGLPLAYEVKGNCTVPLEIDYLPLASYLGYYVVLGNGTLSWKNYTVKTPMRMYFGHNTNYPWRKGYVSLELYQKNGHPVIVFPWEIWHNQTRKAKKGYFAYEITERGFVIINTTDKKELGKNLIPSSVLMGKWNNVTGTLIVDIPNKTAFLITDKEKIPVNFTVAKKTESVVVGNSTFLFITYYEAFILPPWIKPVNVNRMLELYREMDRKCLEEETKVSNGTTKSITFLTGIATIVIFVTLWRFWKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMU8</accession>
    <name>F0LMU8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01101"/>
    <dbReference type="EnsemblBacteria" id="ADT84077">
        <property type="protein sequence ID" value="ADT84077"/>
        <property type="gene ID" value="TERMP_01101"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01101"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1104"/>
    <dbReference type="eggNOG" id="arCOG05778">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1870846_0_0_2"/>
    <dbReference type="OMA" id="EHHVSMR"/>
    <dbReference type="OrthoDB" id="107270at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020948">
        <property type="entry name" value="P_starv_induced_PsiE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06146">
        <property type="entry name" value="PsiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="139" mass="16228" checksum="7A15D96B4D159325" modified="2011-05-03" version="1">MAKMEEEKVAQYTQVHKAFRKTLEICFDMVVMVFLFFILYLTMYSIYLNFKLTYKVAEPKLLIANVLVTIILIETYRILIIYLRQHRVSLTHILEVGIVALIQKLVVASDFRELDAIKLFAIAGLIFVLGYLYIKIGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMV0</accession>
    <name>F0LMV0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467377.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01103"/>
    <dbReference type="EnsemblBacteria" id="ADT84079">
        <property type="protein sequence ID" value="ADT84079"/>
        <property type="gene ID" value="TERMP_01103"/>
    </dbReference>
    <dbReference type="GeneID" id="10041420"/>
    <dbReference type="KEGG" id="tba:TERMP_01103"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1106"/>
    <dbReference type="eggNOG" id="arCOG10268">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_800818_0_0_2"/>
    <dbReference type="OrthoDB" id="104280at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="346" mass="40223" checksum="DB95FB4993872BE5" modified="2011-05-03" version="1">MGRALKALSILAAFAAVSFLLLKPNNIYLEVYYPGSLEYLGYKHGSFEFELVERSDEINIITVKDRIWTLIDEDLKNNPMYVRVNGDKFRAVLRFWHELPIKGEDLIYIASPYNFTELAVVHLPENYTLKGWEFEKGALILEIEPADRNEGRVIIHNEKLREVQAKIKYQYAPVFYTYRGRIIARGEVHERVPGVPLYIYPGEITQGIFPQHDLYDLINVKNILLSHYEVRLKQNETITVEGRILPAPWKFNYTRGVNAGKVRLEAYCGPDREEWEWSYLRRSLYEPEGLKIQITPEVFEIPVNGSAEFKVQITAEKDSLFCPLFIIAFADEGWKSWERVRIIVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMX7</accession>
    <name>F0LMX7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bifunctional IPC transferase and DIPP synthase</fullName>
            <ecNumber evidence="5">2.7.7.74</ecNumber>
            <ecNumber evidence="6">2.7.8.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_01130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol = bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:62573"/>
            <dbReference type="ChEBI" id="CHEBI:62576"/>
            <dbReference type="EC" id="2.7.8.34"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1D-myo-inositol 3-phosphate + CTP + H(+) = CDP-1L-myo-inositol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30647"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:62573"/>
            <dbReference type="EC" id="2.7.7.74"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the MobA family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.74" evidence="5"/>
    <dbReference type="EC" id="2.7.8.34" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467404.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01130"/>
    <dbReference type="EnsemblBacteria" id="ADT84106">
        <property type="protein sequence ID" value="ADT84106"/>
        <property type="gene ID" value="TERMP_01130"/>
    </dbReference>
    <dbReference type="GeneID" id="10041447"/>
    <dbReference type="KEGG" id="tba:TERMP_01130"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1133"/>
    <dbReference type="eggNOG" id="arCOG00673">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643435_0_0_2"/>
    <dbReference type="OMA" id="MVSYSTE"/>
    <dbReference type="OrthoDB" id="115624at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="NTP_transferase" evidence="10">
        <location>
            <begin position="6"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT84106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="428" mass="48114" checksum="57EEA2B0DB3C35A2" modified="2011-05-03" version="1">MTPKRAVILAAGLGTRLRKLTEETPKGLLKVAGREILYRTMKVLQELGVEEFIIVTNPKYETKFREFAKKNSFKVQIVINEHPEKGNGYSLYLAKDLVGEKFILVMSDHIYGKAFLERAVKGKGLIVDKAPKYTSVEEATKVRIKDSCVEDIGKHLKDFDAIDTGFFVLTPEIFDVADEILSEKGKAELSEIVKRAKLKVTSVSGFFWMDIDTPEDIKKARKLVIQSSVKGSGDGVISRHLNRKISTRISSFLVDYVTPNQMTVVTFLLGILSALLNFVSIPLAGILYQISSILDGVDGEIARASMKTSRFGGYVDSILDRYVDFAFLLTLAYVTIKEPLWWAIAVTAIFGSAMVSYSTERYKAAYGSDIYREIYTMRYLIGKRDERIFLTMLFCLAGQIKALFALLAVLTNLRIAATVWLVWKNKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMY1</accession>
    <name>F0LMY1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative perplasmic sugar binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467408.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01134"/>
    <dbReference type="EnsemblBacteria" id="ADT84110">
        <property type="protein sequence ID" value="ADT84110"/>
        <property type="gene ID" value="TERMP_01134"/>
    </dbReference>
    <dbReference type="GeneID" id="26136597"/>
    <dbReference type="KEGG" id="tba:TERMP_01134"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1137"/>
    <dbReference type="eggNOG" id="arCOG00152">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031522_0_0_2"/>
    <dbReference type="OMA" id="WTEWQTK"/>
    <dbReference type="OrthoDB" id="8229at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="541" mass="61001" checksum="BE80DD117F02E471" modified="2011-05-03" version="1">MKAKAVWLVAILLLGVIASGCIGGEKETATQTAGKVQLTGDFTKDVVAIGKVLEQNGINEVKFSAWGSGDPNSVMRVYGIVEAARRINKIWEDNGIKVKIVITDTHYVASFQDAYKEYLSKQPLGQAGDFFVNSYAFLPTLADEGYILDITDYANAYKSVIDDFYPSLIEASKYKGRLYGLPQDTEARPLYVRKDVAAKIGLDVNTLPEKVKSGEFTWSDVYYWAKKAKESGAAEWGLIHRKGSAHPDLIQFIFAFGGKLYDPNTGKLVVDVPAVYKWLYVEWKFAQDGLLPKDIMSWDWAKQIHPTIVEGKTLFDIGGTWYWTEWQTKQYYHGRGLKPEEVKEWFAYTLFPAGEKGDKPVTLSQPFIWMINSKAGAQNPKYDELKDVYHMLAFLMVIKASDPDINAIHSVISAHLPVRKEAAKLIKDEKWLNDLKNLNLDLDPTVKDNIKNIVQATVNPINAQFLADVSYMLEYTHLAPAHPKYPALADIFKEAVDKVLRGEMTPEDAVNYIIQKVNADPELKENVEIQGEIPKNWKFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMZ1</accession>
    <name>F0LMZ1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monovalent cation/proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467418.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01144"/>
    <dbReference type="EnsemblBacteria" id="ADT84120">
        <property type="protein sequence ID" value="ADT84120"/>
        <property type="gene ID" value="TERMP_01144"/>
    </dbReference>
    <dbReference type="GeneID" id="10041461"/>
    <dbReference type="KEGG" id="tba:TERMP_01144"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1147"/>
    <dbReference type="eggNOG" id="arCOG03082">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121334_0_2_2"/>
    <dbReference type="OMA" id="VAPIGSH"/>
    <dbReference type="OrthoDB" id="105926at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="119" mass="12565" checksum="403225AC964250F8" modified="2011-05-03" version="1">MSEVLFYLGALMIIIGGICDLFGALGLLRFPNFYIRLHAATVGTIGGAVVPLFGVGFLALGSDFLPHKYAIAGASFVTGIIVLLAAPAGAHALAYAAHRAKIVKWEPKCDHLAEVREND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN39</accession>
    <name>F0LN39_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467466.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01192"/>
    <dbReference type="EnsemblBacteria" id="ADT84168">
        <property type="protein sequence ID" value="ADT84168"/>
        <property type="gene ID" value="TERMP_01192"/>
    </dbReference>
    <dbReference type="GeneID" id="10041509"/>
    <dbReference type="KEGG" id="tba:TERMP_01192"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1195"/>
    <dbReference type="eggNOG" id="arCOG01310">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050811_0_0_2"/>
    <dbReference type="OMA" id="LWATGNY"/>
    <dbReference type="OrthoDB" id="48602at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027552">
        <property type="entry name" value="CGP_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04288">
        <property type="entry name" value="CGP_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="375" mass="40079" checksum="58E021FAEFF8DD9D" modified="2011-05-03" version="1">MKKLAVLLSVFVLFGLFGVAFASAATVAVDLAHGENDKYLAGDVIDRDTNETLAHGIVKTITDVKWAYFGDPAAADTLGIPHLGDKITADALKGVDMLIIGQPSSPFEPDEIQAIAEWFKQGGKVLWIAGDSDYGSGVQVQETVNALLDQLGIGHLRLDLCSVEDPVSNAGAGYRVVGIVNPDPNTPDASMITQGFKHGGKVLYHGPGVVAYVDDQGNWHTLTDNIPENVYRIVKTSKDGTIVENNDPPANAYMAGDTGVFPLLAVEFVKLDNGKQSLLIVSGESPYGDYEPTWAPKYHGVPLDGPTFVTNFIHWALKEASKVEEKPTETTTEKPTETEKPTETGTSAPATTSKTCGPAVLVGLALIPLLLRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN81</accession>
    <name>F0LN81_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="10" type="ordered locus">TERMP_02247</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="10 11">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
            <plasmid evidence="10 11">pTBMP1</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02247"/>
    <dbReference type="EnsemblBacteria" id="ADT85220">
        <property type="protein sequence ID" value="ADT85220"/>
        <property type="gene ID" value="TERMP_02247"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02247"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2241"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="TKMMHDK"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0614">Plasmid</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="117"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="213"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT85220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="301" mass="34098" checksum="373B855BB957A960" modified="2011-05-03" version="1">MYFGVDVGKCPSCGSSKLIYDYERGEIFCAVCGSIVTQDIVDLRQEWRAFDASQREKRSRTGAPESILLHDKGLSTDIGSDRNITGLMREKMYRLRKWQSRLRVSDAAERNLAFALSELDRIASQLKLPRHVEEEAARLYREAIRKGLIRGRSIESVIAACVYAACRLLKIPRTLDEIADIARVDKKEIARSFRFIARNLNLTPKKLFVKPTDYVNKFADELGLSEKVRRRAIELLEEAYNRGLTSGKSPAGLVAAALYIASLLEGEKRTQREVAEVARVTEVTVRNRYKELVEKLGLSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGU7</accession>
    <name>F0LGU7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466284.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00008"/>
    <dbReference type="EnsemblBacteria" id="ADT82986">
        <property type="protein sequence ID" value="ADT82986"/>
        <property type="gene ID" value="TERMP_00008"/>
    </dbReference>
    <dbReference type="GeneID" id="10040327"/>
    <dbReference type="KEGG" id="tba:TERMP_00008"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.7"/>
    <dbReference type="eggNOG" id="arCOG04084">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_800776_0_0_2"/>
    <dbReference type="OMA" id="FEYKVGW"/>
    <dbReference type="OrthoDB" id="26182at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT82986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="340" mass="38477" checksum="73D59C435CA72A68" modified="2011-05-03" version="1">MLIYDIPEVKRENKTTDIVKRTGVLSANNIHLTNYPGKPAAIFNPGLLIEGDTLTVYARMVTGYYMHPYSSAIVEFKIPVDDLDEVPRKRYEGKLIIIPDTEYDMWGVEDPRATIVNGEKVLVYCGLTKRYYTEELFRNLPVAAVYRDGSWKKIGAFKVKGAKVVGDKDAFLAEMNGLKMFQRPTIRENGTTKDLCVISEVPEDIFETSEPREIETYNGIVPIDKEKFEYKIGWGTPPLKVGKDEYLLILHAADMDAVYKAFAVLMNSNGKITAVTPHYIMEPREIYEKYGDRPHVVFPTGIARLDDEILIAYGAADSFIGIGKIDFSEIMSILDSNRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGW7</accession>
    <name>F0LGW7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466304.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00028"/>
    <dbReference type="EnsemblBacteria" id="ADT83006">
        <property type="protein sequence ID" value="ADT83006"/>
        <property type="gene ID" value="TERMP_00028"/>
    </dbReference>
    <dbReference type="GeneID" id="10040347"/>
    <dbReference type="KEGG" id="tba:TERMP_00028"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.27"/>
    <dbReference type="eggNOG" id="arCOG10076">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1544268_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="173" mass="19933" checksum="2C9BCD72CB6E7650" modified="2011-05-03" version="1">METSDTGEIKVLNITIAKWSPDRDSYISGNAVYLYGGFLGYCSDAFTYNISGFTIDIYILEDWTVDVLFNRTPRRVKTVAGETVTLVCPLVLLGGRLVIELEDMPENLTINVWLDDYRDRKVELRLYERWHLKNGSVQRGAYPPLKGIRTLSIEQVRNIIEKHGLFNIEDQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGX3</accession>
    <name>F0LGX3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagella protein FlaC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467479.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01205"/>
    <dbReference type="EnsemblBacteria" id="ADT84181">
        <property type="protein sequence ID" value="ADT84181"/>
        <property type="gene ID" value="TERMP_01205"/>
    </dbReference>
    <dbReference type="GeneID" id="10041522"/>
    <dbReference type="KEGG" id="tba:TERMP_01205"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1208"/>
    <dbReference type="eggNOG" id="arCOG05119">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123708_1_0_2"/>
    <dbReference type="OMA" id="NQINPFI"/>
    <dbReference type="OrthoDB" id="104764at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009205">
        <property type="entry name" value="FlaC_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05377">
        <property type="entry name" value="FlaC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018660">
        <property type="entry name" value="Archl_flaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="163" mass="19106" checksum="7737E1BC00762887" modified="2011-05-03" version="1">MSFSYLKNKFKKKNGGATQDDNVEIIRLDELNESEATEEKKKEEEELLNQVMTRINEIENDIPRIKVSIDTLKSQIQEVQEEVEKLNKTIKDVMMLYEVVSQEINPFKDQEKDNPLLNEIQELKRQLEELRTEIVQLKSDLKLLATHGIDLDEVIYEVISEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGY2</accession>
    <name>F0LGY2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01214"/>
    <dbReference type="EnsemblBacteria" id="ADT84190">
        <property type="protein sequence ID" value="ADT84190"/>
        <property type="gene ID" value="TERMP_01214"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01214"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1216"/>
    <dbReference type="eggNOG" id="arCOG00381">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989094_0_0_2"/>
    <dbReference type="OMA" id="EFYFIVG"/>
    <dbReference type="OrthoDB" id="54951at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="259"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="310" mass="35464" checksum="C646B39B8C7475B3" modified="2011-05-03" version="1">MSPVENQKSKRRKSALIIMLFVIFLLPFASSQGEYDYNIESYSIYFDIVNDNTIKETIEISLTANTNFSRYVFYSDYPIENPDAIVKINGEMKIVNVSVSKIVGGINAVYVKFPPVKKGDRITIKISFYSSGMLQNVQNKKQFAYYIRFNQPVNLFYVRLFIPKGYAILSPIIPSPDMVESSENRLVLEWRRENIKAGEEFYFIVGFSGEIKGFSPLWLVVIFVSAFAGGFFAGMLYKERKGKEKVEVLRSDEEKVIELLKNGPVLQSELVKKLGVSKAKVSLLLKDMEKKGLIERVKEGRSYLVRLKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH39</accession>
    <name>F0LH39_THEBM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84247">
        <property type="protein sequence ID" value="ADT84247"/>
        <property type="gene ID" value="TERMP_01271"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01271"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1274"/>
    <dbReference type="eggNOG" id="arCOG08607">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_210078_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="48" mass="5579" checksum="74EDD1CF01BAA014" modified="2011-05-03" version="1">MLARIVYYKLNSLPEEEIVVVNSFEKAVEIARRKIRMMGAVKVEVEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH81</accession>
    <name>F0LH81_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamate synthase small chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00065"/>
    <dbReference type="EnsemblBacteria" id="ADT83043">
        <property type="protein sequence ID" value="ADT83043"/>
        <property type="gene ID" value="TERMP_00065"/>
    </dbReference>
    <dbReference type="GeneID" id="10040384"/>
    <dbReference type="KEGG" id="tba:TERMP_00065"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.65"/>
    <dbReference type="eggNOG" id="arCOG01292">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_3_2"/>
    <dbReference type="OMA" id="QETQCEQ"/>
    <dbReference type="OrthoDB" id="83293at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006004">
        <property type="entry name" value="Glut_synth_NADPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01316">
        <property type="entry name" value="gltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="3">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="152"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="470" mass="51953" checksum="56290BB43A4EF884" modified="2011-05-03" version="1">MPKRQIIKERVPTPERPPEERNKDFFEVNLGYDFELAKKEAERCLQCPEKYAPCIKGCPVNINIPAFIAKIKEGDIRGALEVIWACNSLPAITGRVCPQEDQCEGVCVMGKVGDPINIGKLERFVADYAREKGIDAELLGEQIKGIKKNGRKVAVIGAGPAGLTCAAELAKMGYDVTIFEALHKPGGVLIYGIPEFRLPKQIVKKELENLKKLGVKIETNTLVGKTVTFDELREEYDAIFIGTGAGTPRFVKWEGINLNGIYSANEFLTRINLMKAYEFPEYDTPIKVGKRVAVIGGGNTAMDAARSALRLGAEVWILYRRTRKEMTARIEEIHHAEEEGVKFMFLVSPKRFIGDEHGNLKAIELEKMKLGEPDETGRRRPIPTGETFIMEFDTAVIAIGQTPNKTFFQTVPDLKVDSKGRIIVDGNLMTSIPGVFAGGDAIRGEATVILAMGDGRKAAKAIHEYLSKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHC8</accession>
    <name>F0LHC8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467553.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01280"/>
    <dbReference type="EnsemblBacteria" id="ADT84255">
        <property type="protein sequence ID" value="ADT84255"/>
        <property type="gene ID" value="TERMP_01280"/>
    </dbReference>
    <dbReference type="GeneID" id="10041596"/>
    <dbReference type="KEGG" id="tba:TERMP_01280"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1282"/>
    <dbReference type="eggNOG" id="arCOG05835">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_691909_0_0_2"/>
    <dbReference type="OMA" id="TGPAFWT"/>
    <dbReference type="OrthoDB" id="22091at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="5"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="397" mass="43947" checksum="AAE6E874975D2C86" modified="2011-05-03" version="1">MNRWRSVILNTIVMTAGFGTLTMMSVAKPDVIAHFGISSDAFDLQHIAYVFGLFVAFLLGHTRIYEGSFKRSVAIALSWAAVPQLLIPYAPNWYVAVFLRFIQGFVVTLVPLFSTQIARYFVAERPFAKGIILSGIFWGGVFGSMSAKYLIHAFGWKGGFLVTVLIMYAVLLIWWLFTEDFEIIHERGEAKINVWKLKFTWVLGFTFFPALWVIFTIVGFSASIAYDMGWTKAHVATLSTNLNISKAIWSIVFGYIGYLLSRKNPTSRGLFRAIVQVMVISYMLSFVGLIVYAKAMLSGNYTIALAAVWLVGTIQGTGPAFWTSAPATYPKSVYPRASFALGLISNTANIVAPSITDLLARHSVGLAFGELALMPLVGILTLIAVSRMKMPVEEFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHE7</accession>
    <name>F0LHE7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467572.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01299"/>
    <dbReference type="EnsemblBacteria" id="ADT84274">
        <property type="protein sequence ID" value="ADT84274"/>
        <property type="gene ID" value="TERMP_01299"/>
    </dbReference>
    <dbReference type="GeneID" id="26136779"/>
    <dbReference type="KEGG" id="tba:TERMP_01299"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1301"/>
    <dbReference type="eggNOG" id="arCOG00492">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_2"/>
    <dbReference type="OMA" id="MRLNFTY"/>
    <dbReference type="OrthoDB" id="51060at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="61"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="415" mass="47472" checksum="FE50946ABBB658EB" modified="2011-05-03" version="1">MEEMLQKKLESKVLDYESYFSEKALQMKASEIRELLKLVETSDVISMAGGLPNPATFPKEEIKQIAQEVIEEHADKALQYGTTKGFTPLRLKIAEWLRDRYGIPISKVDIMVVSGSQQALDLIGRTFINPGDLIVVEAPTYLAALNAFKYYEPNFIQIPLDDEGMRVDLLEEKLRKLKAENKKVKFVYTVPTFQNPAGVTMSEERRKYLVELASEYDFLVIEDDPYGELRYSGKPVPPIKKFDTEGRVFYFGTFSKILAPGFRLGWIAGEPHFIRKIEIAKQAVDLCTNPFGQVIAWKFLEKGLLEKHIPRIIKFYKPKRDAMLDALEDYMPEGVKWTKPEGGMFVWATVPESIDTKKMLEKAVAKGVAYVPGEAFFAYRDVKNTMRLNFTYVDEEKIKIGIQKLAETIKEELGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHE9</accession>
    <name>F0LHE9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribose 1,5-bisphosphate isomerase</fullName>
            <shortName evidence="3">R15P isomerase</shortName>
            <shortName evidence="3">R15Pi</shortName>
            <ecNumber evidence="3">5.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribulose 1,5-bisphosphate synthase</fullName>
            <shortName evidence="3">RuBP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate</text>
            <dbReference type="Rhea" id="RHEA:32243"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:68688"/>
            <dbReference type="EC" id="5.3.1.29"/>
        </reaction>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">Reaction proceeds via a cis-phosphoenolate intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.29" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467574.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01301"/>
    <dbReference type="EnsemblBacteria" id="ADT84276">
        <property type="protein sequence ID" value="ADT84276"/>
        <property type="gene ID" value="TERMP_01301"/>
    </dbReference>
    <dbReference type="GeneID" id="26136780"/>
    <dbReference type="KEGG" id="tba:TERMP_01301"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1302"/>
    <dbReference type="eggNOG" id="arCOG01124">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_2_1_2"/>
    <dbReference type="OMA" id="GDVIMTH"/>
    <dbReference type="OrthoDB" id="36100at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043917">
        <property type="term" value="F:ribose 1,5-bisphosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02230">
        <property type="entry name" value="R15P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005250">
        <property type="entry name" value="Ribulose_e2b2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00511">
        <property type="entry name" value="ribulose_e2b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="20"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="212"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="322" mass="36417" checksum="79ACB0B96F3D842D" modified="2011-05-03" version="1">MTLVKEVYEIAEKIKNMEIRGAGKIARSAALALQIQAEKSKAKTAEELWKELKEAAKLLHSTRPTAVSLPNALRYVMYRGKIAYQGRADLEQLRFIVINAAKEFIHNSEKAIERIAEFGAKRIEDGDIIMTHCHSKAAIGVMKKAWDDGKDIKVIVTETRPKWQGKLTAKELAEYGIPVIYVVDSAARHYMKMTDKVIMGADSITANGAVINKIGTALIALTAKEHRVWVMIAAETYKFHPETMLGQLVEIEMRDPHEVIPKEELETWPKNIEVWNPAFDVTPPEYVDVIITEKGVIPPYAAIDILKEEFGWAFKYTEPWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHI5</accession>
    <name>F0LHI5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatinine amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467610.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01337"/>
    <dbReference type="EnsemblBacteria" id="ADT84312">
        <property type="protein sequence ID" value="ADT84312"/>
        <property type="gene ID" value="TERMP_01337"/>
    </dbReference>
    <dbReference type="GeneID" id="10041653"/>
    <dbReference type="KEGG" id="tba:TERMP_01337"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1337"/>
    <dbReference type="eggNOG" id="arCOG04536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_3_1_2"/>
    <dbReference type="OMA" id="PCFLWSG"/>
    <dbReference type="OrthoDB" id="35243at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="236" mass="26887" checksum="4ECEF84CA8A3F197" modified="2011-05-03" version="1">MYMENLTWDEFNEIKKKIDTVILPIGSVEAHGKHLPLGTDVFAPVEIAKRVEAKLREKGKEILIAPPIWYGHSFVLDVFPGTINVKADTLRRYVRDVMAEFAEEGFRKIILLNGHGGNYYPLVEAAEEVARRYNVEVWLINWWIDFREDILSICSSQGHAGEDETSVILAIKPELVKMEKAEGEKRTSKVRKIRKDIALELFPNGVNDDPRGATKEKGEAILEVISKKIARFILED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHI8</accession>
    <name>F0LHI8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-hydroxybenzoate polyprenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467613.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01340"/>
    <dbReference type="EnsemblBacteria" id="ADT84315">
        <property type="protein sequence ID" value="ADT84315"/>
        <property type="gene ID" value="TERMP_01340"/>
    </dbReference>
    <dbReference type="GeneID" id="26136824"/>
    <dbReference type="KEGG" id="tba:TERMP_01340"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1340"/>
    <dbReference type="eggNOG" id="arCOG00476">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1060153_0_0_2"/>
    <dbReference type="OMA" id="INNCFDV"/>
    <dbReference type="OrthoDB" id="71004at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="264" mass="28802" checksum="2AA7130DDB47E450" modified="2011-05-03" version="1">MLRAMIKNTRIIDGKSFIGMGLLGLVISFKYNPDFKDAVLVLISLILYVAYAFAINNCFDVDTDLVNPQKRDKNPIANGELTFKNGIISSAVIGFLGILFAAFLGREELLIYVSMVLLATLYSAPPRLKALPVLDVVSHGIFFGAMPFFYGAFFDGVLTKYEIVIGLALLLYSFAMELRNHLEDYESDLAANLKTTPIVIGKALSEKLVVVFSGISIALLLAALNIPFGAFGIMIVGVRANYRTLDAVVIFLLALHALRVLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHK2</accession>
    <name>F0LHK2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multisubunit Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467627.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01354"/>
    <dbReference type="EnsemblBacteria" id="ADT84329">
        <property type="protein sequence ID" value="ADT84329"/>
        <property type="gene ID" value="TERMP_01354"/>
    </dbReference>
    <dbReference type="GeneID" id="26136838"/>
    <dbReference type="KEGG" id="tba:TERMP_01354"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1354"/>
    <dbReference type="eggNOG" id="arCOG03120">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125825_2_0_2"/>
    <dbReference type="OMA" id="LVNPFGW"/>
    <dbReference type="OrthoDB" id="128222at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34702">
        <property type="entry name" value="PTHR34702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="94" mass="10443" checksum="DFDF7473CD526F9A" modified="2011-05-03" version="1">MVEENILVNPFGWGVIVLISTSVMLMYRVLFGPTLPDRVVGLNTITTKVVVIIAILSVINKQYFLVDLAVVLLMVNAVGGLILAKYLERRGRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHN1</accession>
    <name>F0LHN1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps2</name>
        <name evidence="7" type="ordered locus">TERMP_00138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466413.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00138"/>
    <dbReference type="EnsemblBacteria" id="ADT83115">
        <property type="protein sequence ID" value="ADT83115"/>
        <property type="gene ID" value="TERMP_00138"/>
    </dbReference>
    <dbReference type="GeneID" id="10040456"/>
    <dbReference type="KEGG" id="tba:TERMP_00138"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.139"/>
    <dbReference type="eggNOG" id="arCOG04245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058171_3_0_2"/>
    <dbReference type="OMA" id="QQKTKDM"/>
    <dbReference type="OrthoDB" id="63341at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_A">
        <property type="entry name" value="Ribosomal_S2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023454">
        <property type="entry name" value="Ribosomal_S2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_S2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="PTHR11489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="201" mass="22990" checksum="8332DEA71DD6A901" modified="2011-05-03" version="1">MDEYLVPLDQYLAAGVHIGTQQKTKDMKKFIYRVRQDGLYVLDVRKTDERLRIAGKFLAKFEPDKVLAVSVRLYGQKPVKKFGEVTGARAIPGRFLPGTMTNPAVKNFFEPDVLIVTDPRADHQALKEAVEVGIPIVALVDTENLLSYVDLAIPTNNKGRKALALIYWILAREILYNRKEIENREDFKVPVEDFEMRIIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHP8</accession>
    <name>F0LHP8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466430.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00155"/>
    <dbReference type="EnsemblBacteria" id="ADT83132">
        <property type="protein sequence ID" value="ADT83132"/>
        <property type="gene ID" value="TERMP_00155"/>
    </dbReference>
    <dbReference type="GeneID" id="26135480"/>
    <dbReference type="KEGG" id="tba:TERMP_00155"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.156"/>
    <dbReference type="eggNOG" id="arCOG01042">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131306_1_1_2"/>
    <dbReference type="OMA" id="RTFCYAT"/>
    <dbReference type="OrthoDB" id="104786at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="151" mass="17497" checksum="5BCA54EA0478A2C0" modified="2011-05-03" version="1">MAKLQAHSVKIRTFIHATEDPEKVLEALETLFPEDLSPQDVDFEIIETEGYFGNPILVMDAEIRKSKNVRRFLENLKALLSEEDKAYLMEHAEEKVDETGTLYIRFDKQRAYLGEVKVTEGEDVIHVRIKVKAFPMKKESVVKSVKEWLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHQ8</accession>
    <name>F0LHQ8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L37Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ribosomal protein L43e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl37ae</name>
        <name evidence="3" type="ordered locus">TERMP_00165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00165"/>
    <dbReference type="EnsemblBacteria" id="ADT83142">
        <property type="protein sequence ID" value="ADT83142"/>
        <property type="gene ID" value="TERMP_00165"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00165"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.166"/>
    <dbReference type="eggNOG" id="arCOG04208">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141199_2_0_2"/>
    <dbReference type="OMA" id="ISTGIWQ"/>
    <dbReference type="OrthoDB" id="122290at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_L37Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_L37ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="84" mass="9045" checksum="3243623F80A6FB0A" modified="2011-05-03" version="1">MATKKVGSAGRFGPRYGLKIRRRVAAVEAKMKQKHTCPVCGRKAVRRISTGIWQCQKCGATFAGGAYLPVTPAGKVAKRIVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHT1</accession>
    <name>F0LHT1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbamoyltransferase</fullName>
            <ecNumber evidence="8">6.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TERMP_01356</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55636"/>
            <dbReference type="Rhea" id="RHEA-COMP:14247"/>
            <dbReference type="Rhea" id="RHEA-COMP:14392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:76913"/>
            <dbReference type="ChEBI" id="CHEBI:139126"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; [NiFe] hydrogenase maturation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carbamoyltransferase HypF family.</text>
    </comment>
    <dbReference type="EC" id="6.2.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467629.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01356"/>
    <dbReference type="EnsemblBacteria" id="ADT84331">
        <property type="protein sequence ID" value="ADT84331"/>
        <property type="gene ID" value="TERMP_01356"/>
    </dbReference>
    <dbReference type="GeneID" id="10041672"/>
    <dbReference type="KEGG" id="tba:TERMP_01356"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1356"/>
    <dbReference type="eggNOG" id="arCOG01187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009164_0_0_2"/>
    <dbReference type="OMA" id="VQHHYAH"/>
    <dbReference type="OrthoDB" id="6307at2157"/>
    <dbReference type="UniPathway" id="UPA00335"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046944">
        <property type="term" value="P:protein carbamoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004421">
        <property type="entry name" value="Carbamoyltransferase_HypF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041440">
        <property type="entry name" value="HypF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011125">
        <property type="entry name" value="Znf_HypF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17788">
        <property type="entry name" value="HypF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07503">
        <property type="entry name" value="zf-HYPF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006256">
        <property type="entry name" value="CMPcnvr_hdrg_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00143">
        <property type="entry name" value="hypF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="10">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="11">
        <location>
            <begin position="200"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT84331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="770" mass="86778" checksum="F015A4B86823F1A3" modified="2011-05-03" version="1">MKAYHIHVEGIVQGVGFRPFVYRIAHEHNLRGYVKNLGDAGVEIVVEGEEHDIKAFLHDLKYRAPPLAKIEKVKKREIPPQGFDNFYIEKSSQGGSGGDSIIPPDVSICEDCIRELFDPTNKRYMYPFIVCTNCGPRFTIIEDLPYDRINTTMREFEMCEFCESEYKDPLNRRYHAEPVCCPVCGPSYRLYTRDGEEIIGDPIKKTAELIDKGYIVAIKGIGGIHIACDATNEDVVEELRKRILRPQQPFALMAKDLETIESFAIVSDAEKEELLSYRKPIVALRKKEPFPLPEALAPGLHTIGVMLPYSGIHYLLFHYSKSPVYVMTSANYPGLPMVKDNDKAFKELKDLADYFLLHNRKILNRADDSVIRFVDGKRAVIRRSRGFVPLPIDIPFEFIGLAVGAELLNAFGFAKNRRVYPSQYIGNTSKVEVLEFMREAIAHFRKILRIKNLDLVISDLHPLYNTTKLAMEIAENEGVEFLQVQHHYAHIASVMAENKLDEIIGIAVDGVGYGVDGNTWGGEVIYMSYEDVERLAHIDYYPLPGGDLASYYPLRALVGILSKIYDIEEVKGVIQRCCPKAIDSLKYGKVEFNVILNQLAREINVSYASSTGRVLDAFAVMLNVAYRRTYEGEPAMKLESFAFRGKNDLGFSIPIDGEKIKVEEMFRQALEVKANPADIAYSVHLALGRAFGEIAVEKAREFGVKNVGVSGGVAYNELIVKTIRKIVERNGLKFYVTQEVPRGDNGINVGQAFLGGLYLEGYLSKEDLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHT3</accession>
    <name>F0LHT3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase accessory CooC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="245" mass="26990" checksum="74A4E6C01FD54CE1" modified="2011-05-03" version="1">MKILICGKGGCGKSTITAMLGKYLANKGHRVLIVDADESNPGLYRMLGLSKTKTLAEYLGGKQRVKAILDSPELPKTFEEIPEEILSKRENLSVISIGKIEDPGEGCACPYGVLAKKFLKNLQPKKGEIVLVDTEAGIEHFGRGIDLEVDVIVNVAELNLESIELSRKIEKLAEKAGLKHIFVLNKALPEVLDKVNVKPDVVIPFNQKFIYESLEGKEIEIVPQIEELWECISKLSAQDPQSEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHU5</accession>
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            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
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        <name evidence="2" type="ordered locus">TERMP_01370</name>
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        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
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            <taxon>Archaea</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
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            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 11836 / MP</strain>
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        <property type="project" value="InterPro"/>
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            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="243" mass="27049" checksum="1C3223DEE7E9BACD" modified="2011-05-03" version="1">MLEKEKEALAKRIAGEITLSSDPGKTMRKWREIFGISQTELAEYLGVSSSVISDYEGGRRKSPGASTIRKFVEALLEIDERRGGNVIKAFSKTLGSEFPTSAILDIREFALPVTVRDIVNAVKGEVAANIDLLDRPIYGYTVVDSIQAILEMSSEEFLKLYGWTTERALVFTKVTTGRSPMIAIRVQGLKPAVVVLHGVKKLDELAVKIAEKERVPLVVSKVETESELIMNLRKLVEKREKEL</sequence>
</entry>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
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        <property type="gene ID" value="TERMP_00199"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00199"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.200"/>
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    <dbReference type="Proteomes" id="UP000007478">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="47" mass="5434" checksum="31FAF35F56DD5496" modified="2011-05-03" version="1">MGMKEVEDVKKALSPIVEESREKHGDAVLNFSQSLVETYKFFRALFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI95</accession>
    <name>F0LI95_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BtpA family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01450"/>
    <dbReference type="EnsemblBacteria" id="ADT84425">
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    </dbReference>
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    <dbReference type="KEGG" id="tba:TERMP_01450"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1450"/>
    <dbReference type="eggNOG" id="arCOG01982">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005137">
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    </dbReference>
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        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00259">
        <property type="entry name" value="thylakoid_BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="261" mass="28882" checksum="0C0CB39A82A81135" modified="2011-05-03" version="1">MDFERKVLIGMVHLKPLPGSYLYNGDFGRVIEHAVNEAKKLEKAGFDAVMVENFGDVPFPKYVDKTTVAAFTVVAKAVREEVSLPLGINVLRNDAIAAYSIAYAVKADFIRVNVLSGIAYTDQGIIEGIAHELAKLRKLLPSRIKVFADVHVKHAYHFGEFEDALRDTVERGLADAVIISGKATGMEVDVEKLKKAKKISPVPVIVGSGTTYDNLPKLWKYADGFIVGTWIKKDGKTKNDIDFERAKNLIELAKNLRSSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIB7</accession>
    <name>F0LIB7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ADT84447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01472"/>
    <dbReference type="EnsemblBacteria" id="ADT84447">
        <property type="protein sequence ID" value="ADT84447"/>
        <property type="gene ID" value="TERMP_01472"/>
    </dbReference>
    <dbReference type="GeneID" id="10041788"/>
    <dbReference type="KEGG" id="tba:TERMP_01472"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1472"/>
    <dbReference type="eggNOG" id="arCOG01545">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_2_2"/>
    <dbReference type="OMA" id="FTWVERR"/>
    <dbReference type="OrthoDB" id="88886at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="322" mass="35410" checksum="3178F1661DB919F3" modified="2011-05-03" version="1">MTPETLFYAVAFPVLGVFLGLTYKGIDRRISARMTSRIGPPIRQPFWDVGKLLLKETVVPENAVKWLFNAMPILAFASSMTLLLYIPFGILKAPLEGYGDLIVILYLLTLQSLAMAVGGFSSGSPFSSVGAQREMVLMMSYEMPLAIVIIGFALLYKSFSLTTIASTPVWTMVSPVAALGVVLLFIALLVVTPAELAKLPFDIAEAETEIAEGMLAEYSGRNLALFYLSDAVRGFAMAAIEAVLFIPFTFSYVFGISLNGAMLYIVESLWFLFKVLIIYIAAVTIVRTSFGRFRIEQASRIFWVHVNLIALLGLALVWLGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIC1</accession>
    <name>F0LIC1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467749.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01476"/>
    <dbReference type="EnsemblBacteria" id="ADT84451">
        <property type="protein sequence ID" value="ADT84451"/>
        <property type="gene ID" value="TERMP_01476"/>
    </dbReference>
    <dbReference type="GeneID" id="10041792"/>
    <dbReference type="KEGG" id="tba:TERMP_01476"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1476"/>
    <dbReference type="eggNOG" id="arCOG05308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2103359_0_0_2"/>
    <dbReference type="OMA" id="DYILWYL"/>
    <dbReference type="OrthoDB" id="120936at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="113" mass="12842" checksum="811B6321425A564F" modified="2011-05-03" version="1">MISKLVTGSGYWSPLLWLAFLILFALIGYIIYSRGNPSYKKESEQVKPYLSGNAEPSKEKIQVRASDIYWGFIEALKEYYRVLQAIHTGDVRDYILWYLGVGTVILFLLVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIE9</accession>
    <name>F0LIE9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467777.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01504"/>
    <dbReference type="EnsemblBacteria" id="ADT84479">
        <property type="protein sequence ID" value="ADT84479"/>
        <property type="gene ID" value="TERMP_01504"/>
    </dbReference>
    <dbReference type="GeneID" id="26137015"/>
    <dbReference type="KEGG" id="tba:TERMP_01504"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1504"/>
    <dbReference type="eggNOG" id="arCOG01864">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_44_1_2"/>
    <dbReference type="OMA" id="YEPSIWL"/>
    <dbReference type="OrthoDB" id="122167at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="65" mass="7570" checksum="48A6B5A00CFAF4EE" modified="2011-05-03" version="1">MKNRLRELREARGLTQEELAKILGVTRQTIIAIEKGKYDPSLRLAFKIARFFGVKIEDIFIYEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIL9</accession>
    <name>F0LIL9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ferrous iron transport protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">TERMP_00316</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466591.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00316"/>
    <dbReference type="EnsemblBacteria" id="ADT83293">
        <property type="protein sequence ID" value="ADT83293"/>
        <property type="gene ID" value="TERMP_00316"/>
    </dbReference>
    <dbReference type="GeneID" id="10040634"/>
    <dbReference type="KEGG" id="tba:TERMP_00316"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.316"/>
    <dbReference type="eggNOG" id="arCOG00359">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013350_3_0_2"/>
    <dbReference type="OMA" id="PLGYDWK"/>
    <dbReference type="OrthoDB" id="27688at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="12">
        <location>
            <begin position="2"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT83293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="665" mass="73550" checksum="48150FB9C03468B6" modified="2011-05-03" version="1">MKKVIALAGNPNVGKTTLFNALTGLRQHVGNWPGVTVEKKEGIMKYKGREFLVVDLPGTYSLTAHSVDELIARNFILEGNADVIVDVVDSSCLMRNLFLTMEILEMGVKNVVIALNKIDLAEKKGIKFDFKKMEKVLGIPVVPTNAKDGTGIEELKKKIVAVADGKITVNPVVPVYDDIIEREISHISEILKETALAERYNLRWLAIKLLTRDEEVIKLVLSHLGHEKMDEILHHIGELEGHYKKSLDIIIANQKYEFIDNLIHQFVTHFAEQKEMLTDQLDRILTHPVYGMISLLAIFYLLFKFVFTVGTPLQESLDSFFGVLGDNIGRYIVNDTLRGLIVDGIIGGVGSVLSFFPLVFLLFVAMSLLEDSGYMARAAVVMERIMRKFNLPGKSFIPMILAFGCNVPAVMATRALDDERDRILTMIINPLVPCSARMVVITFLAGVFFERHKALVAISIYAISLGLALISALILSRFVIKGEESPFIIELPDYLIPSWKSVVIHSWERSKEFLKKAGTVILAGAVAIWYLSNYPQPVGTGLSYAEIIGRALEPVTKLMGLDWKAAVSLIFGIIAKENVIATYGVIYGIGGNEEALGVLMRQAMTPLQAFVLSLVTTLYLPCIATIAAIRAEGGTKWALVASLYNLILATVIGILVYHLGLFIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIQ9</accession>
    <name>F0LIQ9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467809.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01536"/>
    <dbReference type="EnsemblBacteria" id="ADT84511">
        <property type="protein sequence ID" value="ADT84511"/>
        <property type="gene ID" value="TERMP_01536"/>
    </dbReference>
    <dbReference type="GeneID" id="26137048"/>
    <dbReference type="KEGG" id="tba:TERMP_01536"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1536"/>
    <dbReference type="eggNOG" id="arCOG05730">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1514687_0_0_2"/>
    <dbReference type="OMA" id="MNYEEHV"/>
    <dbReference type="OrthoDB" id="103153at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="176" mass="19466" checksum="53ADF68A1E7384E3" modified="2011-05-03" version="1">MNYDEHVLGGIITYPLAVLTASLLRAYLNVPFQLSFMAMALGYAFYVLGSDLPDMDHPDALIHRGTKPIVAVAIGISAFLKFSEISITEYEWANLTIAWGVAVLFAFASWYIFSTIMPKHRGIVHSVGFACVYGLLGFALPVYGLGLHWEEGLFVGFAAFMGYLLHLILDKQVKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIU1</accession>
    <name>F0LIU1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01568"/>
    <dbReference type="EnsemblBacteria" id="ADT84543">
        <property type="protein sequence ID" value="ADT84543"/>
        <property type="gene ID" value="TERMP_01568"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01568"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1568"/>
    <dbReference type="eggNOG" id="arCOG04139">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1640051_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="161" mass="17500" checksum="4EAF54724ACDA169" modified="2011-05-03" version="1">MKICILGAGSIGSLFGAILARAGNDVTLIGREEHMRAINDKGLKIIGVEEFTVHPKAVTYAPEYEPDLIILATKSYSTAYALSCAKHCIGKKTWILSIQNGLGNEDLALKYTKNVLGGITTNGAMLEEWELLSGQVRDTKIGVYPKERQLLKSCKVFNDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIW1</accession>
    <name>F0LIW1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467861.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01588"/>
    <dbReference type="EnsemblBacteria" id="ADT84563">
        <property type="protein sequence ID" value="ADT84563"/>
        <property type="gene ID" value="TERMP_01588"/>
    </dbReference>
    <dbReference type="GeneID" id="10041904"/>
    <dbReference type="KEGG" id="tba:TERMP_01588"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1588"/>
    <dbReference type="eggNOG" id="arCOG02625">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065947_2_2_2"/>
    <dbReference type="OMA" id="YVVFHEM"/>
    <dbReference type="OrthoDB" id="115539at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="13"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="222" mass="26732" checksum="139FEF5CAD7FC983" modified="2011-05-03" version="1">MGLNYEVIVRNIKHSRIEIRPDGKIKVIVPPNQNPEELIKRKRGWIEKKLAEIEEFKKQFSQFSDKLLLNGEFYEIINGEKFSVNLKFKVVFLPDNDLRVLKRWLKNQLREELDFKVRLFASILGVKYRKIYIRFQRTKWASCSKKGNLSFNLMLMALPESLRDYIVIHELAHMRIPRHGSQFWGLIGEYYPEYKEAEKKLKTFWLALEWNEVWKKLRETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIZ3</accession>
    <name>F0LIZ3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00362"/>
    <dbReference type="EnsemblBacteria" id="ADT83339">
        <property type="protein sequence ID" value="ADT83339"/>
        <property type="gene ID" value="TERMP_00362"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00362"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.362"/>
    <dbReference type="eggNOG" id="arCOG01102">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134897_0_0_2"/>
    <dbReference type="OMA" id="TGIWMDY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="160" mass="18787" checksum="4DAEC9A74A33A10D" modified="2011-05-03" version="1">MKINELQALASALEIEKAELRFYIQMATKAKNEKAKNMFLFLAREEAEHWDIFEENLIRKVAETGEIPAAIREIVEELTPKYEGTLSEIKAVELGMQQEKATWEFYEKAAEEAEDKKVRELFRRLAKIEEAHYELLKAQYDSVMKTGIWMDYQDFSLEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ49</accession>
    <name>F0LJ49_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467869.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01596"/>
    <dbReference type="EnsemblBacteria" id="ADT84571">
        <property type="protein sequence ID" value="ADT84571"/>
        <property type="gene ID" value="TERMP_01596"/>
    </dbReference>
    <dbReference type="GeneID" id="10041912"/>
    <dbReference type="KEGG" id="tba:TERMP_01596"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1596"/>
    <dbReference type="eggNOG" id="ENOG502N594">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2766295_0_0_2"/>
    <dbReference type="OrthoDB" id="130850at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="69" mass="7751" checksum="FDB515981DA46E45" modified="2011-05-03" version="1">MDREASELRALLRMIRDFGGSASWPVLVNNCSKYGIPLLDLKPLLEIAKQRGLIKEEAGVYTLVRAVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ94</accession>
    <name>F0LJ94_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467914.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84616">
        <property type="protein sequence ID" value="ADT84616"/>
        <property type="gene ID" value="TERMP_01641"/>
    </dbReference>
    <dbReference type="GeneID" id="10041957"/>
    <dbReference type="KEGG" id="tba:TERMP_01641"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1641"/>
    <dbReference type="eggNOG" id="arCOG08595">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2204246_0_0_2"/>
    <dbReference type="OMA" id="LRGMMTL"/>
    <dbReference type="OrthoDB" id="116342at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="106" mass="12624" checksum="093057F70D773501" modified="2011-05-03" version="1">MEEEMLRKIDEYIKSGDEYFKEGNYRLAFRSYLEAMYSISVYIIYKDLGLLMPPGPALGMMKTRYPDVYGLIEKYIPYETRISGIDEELVRIIKSDVEKVYRELIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJA6</accession>
    <name>F0LJA6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neopullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467926.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01653"/>
    <dbReference type="EnsemblBacteria" id="ADT84628">
        <property type="protein sequence ID" value="ADT84628"/>
        <property type="gene ID" value="TERMP_01653"/>
    </dbReference>
    <dbReference type="GeneID" id="10041969"/>
    <dbReference type="KEGG" id="tba:TERMP_01653"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1652"/>
    <dbReference type="eggNOG" id="arCOG02948">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_6_2_2"/>
    <dbReference type="OMA" id="TPDWVKH"/>
    <dbReference type="OrthoDB" id="5581at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02857">
        <property type="entry name" value="E_set_CDase_PDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004185">
        <property type="entry name" value="Glyco_hydro_13_lg-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02903">
        <property type="entry name" value="Alpha-amylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="212"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="659" mass="77799" checksum="951211E0804B52E6" modified="2011-05-03" version="1">MYKIFGFKDDEYLGKVAEVEFSIPKSGSYAYLLGNFNAFNEGSFRMKEKRGRWSVTIELPEGIWYYAFSIDGVFILDPENEGRHTYKRHSYKFERTVNTATIFSGEKFYHSTSLIYVYSSEGATHIRLRAIKGAAKKVFLISDQKYEMEKKAQDDLFEYFEAVLPGKDELEYYFEIHTADGITDYGDFKVDFNEQRGRFKPPVWVFDRVFYQIMPDRFANGNPENDPNDCIELGIGHYGGDLEGIIKKLNHIEELGVNALYLTPIFESMTYHCYDIIDYFHVAEKFGGDKVFKRLINELKKRDIKLILDGVFHHTSFFHPYFQDILEKGKESKYRNFYRTLKFPVVSKDFLKTLHSSEPWLKKYRKLKESKWNYESFFLVWLMPRLNHENPEVRMFIRTVMRYWLERGADGWRLDVAHGVPPDVWREVKKDIPEDAYLIGEVMDDARLWLFDKFHGTMNYPLYEALLRFFIYDEITAEKFLNWLELLSVYYGPAEYTMYNFLDNHDVERFLGLVRDKRKYLCALTFLMTYKGIPAIYYGDEVGLENMNVPSMEASRTPMEWNANRWDKEILKATKDLINLRKTSKALQKGIFKPVKFKDKLLVYKRTLDNESILVAINYSEKKCHLSLPSSFELLFQNGYFNEANMRLGSFSSIVAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJC4</accession>
    <name>F0LJC4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KaiC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467944.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01671"/>
    <dbReference type="EnsemblBacteria" id="ADT84646">
        <property type="protein sequence ID" value="ADT84646"/>
        <property type="gene ID" value="TERMP_01671"/>
    </dbReference>
    <dbReference type="GeneID" id="10041987"/>
    <dbReference type="KEGG" id="tba:TERMP_01671"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1670"/>
    <dbReference type="eggNOG" id="arCOG01171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_2_0_2"/>
    <dbReference type="OMA" id="HSMKKYP"/>
    <dbReference type="OrthoDB" id="76011at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="249" mass="28326" checksum="8B116EFA13223305" modified="2011-05-03" version="1">MVESYVVRRVKSGIPGFDELIEGGFPENTTILVTGSTGTGKTTFGAQFIYKGAEEYGEPGVFVTLEERAKDLRREMLSFGWDFRKYEEQGLIAIVDGVSSSVGLPSEEKFALEDRFNIDNFLRYIYRVVKAINAKRLVIDSVPSIAFRLKEETQIREVLLKLNTILLEMGVTTILTTEAPDPSAGRISRYGIEEYIARGVVILDLQERNIELKRYLLIRKMRETKHSMRKYPFEITNSGIVVYPSGEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJD6</accession>
    <name>F0LJD6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ordered locus">TERMP_00425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466700.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00425"/>
    <dbReference type="EnsemblBacteria" id="ADT83402">
        <property type="protein sequence ID" value="ADT83402"/>
        <property type="gene ID" value="TERMP_00425"/>
    </dbReference>
    <dbReference type="GeneID" id="10040743"/>
    <dbReference type="KEGG" id="tba:TERMP_00425"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.425"/>
    <dbReference type="eggNOG" id="arCOG04134">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024321_0_0_2"/>
    <dbReference type="OMA" id="YEDHRMA"/>
    <dbReference type="OrthoDB" id="80060at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="155"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="403" mass="44320" checksum="4248053D3CB4AD93" modified="2011-05-03" version="1">MIEITPVKTLDGKIRAPPSKSYTHRALFLGLLSEGKTKIENPLICTDTLATLNAVRAFGARADWNFVESSGEVEPAKINAFESGTTARLAIGIGALADGRSVIDGKESLRKRPMEPLLRALNDLGVKTQSNGFLPVRVFGGEIREDYVRVDGSISSQFITALLILGAKVGLSIEVLNPVSKPYLEITLRTLKWANVKVERDDGIFHVHQGVKADHFSIPGDYSSASFFLVAGAIFGKVRVEGLDKEDVQADKLILDLLREFGAEIRTGKDYVEVERDELVGQEVDCRDFPDLFPILAVLGAYSEGKTVLRAKHLRYKESDRIRTMALNLAKMGAKVKELDDGLIISKSELRGTVLNPQNDHRIAMALTIAALGAKGKSLILNERCVEKSYPNFFKDLRGLIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJE4</accession>
    <name>F0LJE4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Histidine biosynthesis bifunctional protein HisIE</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <shortName evidence="15">PRA-CH</shortName>
                <ecNumber evidence="15">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Phosphoribosyl-ATP pyrophosphatase</fullName>
                <shortName evidence="15">PRA-PH</shortName>
                <ecNumber evidence="15">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">hisI</name>
        <name evidence="15" type="synonym">hisIE</name>
        <name evidence="17" type="ordered locus">TERMP_00433</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">In the C-terminal section; belongs to the PRA-PH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 15">In the N-terminal section; belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="15"/>
    <dbReference type="EC" id="3.6.1.31" evidence="15"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00433"/>
    <dbReference type="EnsemblBacteria" id="ADT83410">
        <property type="protein sequence ID" value="ADT83410"/>
        <property type="gene ID" value="TERMP_00433"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00433"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.433"/>
    <dbReference type="eggNOG" id="arCOG02676">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_3_1_2"/>
    <dbReference type="OMA" id="ERSCFHQ"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11534">
        <property type="entry name" value="NTP-PPase_HisIE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01019">
        <property type="entry name" value="HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023019">
        <property type="entry name" value="His_synth_HisIE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRA-CH" evidence="16">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-AMP cyclohydrolase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-ATP pyrophosphohydrolase" evidence="15">
        <location>
            <begin position="123"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ADT83410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="208" mass="24167" checksum="7F6D1E55DB69C0CD" modified="2011-05-03" version="1">MKELIEKVNWERNNGIVPVIVQDTKGEVLTLAYMNKEALMKTLETGYAHYYSRSQKRIRMKGEVSGNVQKVKEIRIDCDNDALLLIVEQVGVACHTGNYSCFYRKLGEPEKAVGGIDYSLTILRELEELIKQRKENPKEDSYTSRLFKEGKEKIYKKFGEEAIEVLVAEGRERIIYETADLLYHLLVLLAYNEISLGKVMEELRRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJE6</accession>
    <name>F0LJE6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8 10">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="5 8 10">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisA</name>
        <name evidence="11" type="ordered locus">TERMP_00435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="5 8 10"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466710.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00435"/>
    <dbReference type="EnsemblBacteria" id="ADT83412">
        <property type="protein sequence ID" value="ADT83412"/>
        <property type="gene ID" value="TERMP_00435"/>
    </dbReference>
    <dbReference type="GeneID" id="10040753"/>
    <dbReference type="KEGG" id="tba:TERMP_00435"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.435"/>
    <dbReference type="eggNOG" id="arCOG00618">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_1_2_2"/>
    <dbReference type="OMA" id="EWLHLVD"/>
    <dbReference type="OrthoDB" id="89881at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="229" mass="25303" checksum="98F25EB6CE119883" modified="2011-05-03" version="1">MKIYPAIDLMNGNAVRLYKGRKDKVKVYGDPVEIAKGFAEYVDKIHIVDLDGAFSGKPQNLGVVGRIIEKTGLRIQLGGGFRDYESIAKAYEIGVENVIIGTKAFDLEFLERVTQDFEGITVSLDAKGGKIAVKGWLEESSISVEEAYEMLRKYVKRFIYTAIEKDGTLTGIGSIERFWNNEEFIYAGGVSSVNDVIKLREIGFSGAIVGKALYEGKVTLEELLNVLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJE8</accession>
    <name>F0LJE8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Imidazoleglycerol-phosphate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466712.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00437"/>
    <dbReference type="EnsemblBacteria" id="ADT83414">
        <property type="protein sequence ID" value="ADT83414"/>
        <property type="gene ID" value="TERMP_00437"/>
    </dbReference>
    <dbReference type="GeneID" id="10040755"/>
    <dbReference type="KEGG" id="tba:TERMP_00437"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.437"/>
    <dbReference type="eggNOG" id="arCOG04398">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044308_2_1_2"/>
    <dbReference type="OMA" id="ARHGLFD"/>
    <dbReference type="OrthoDB" id="91418at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="176" mass="19842" checksum="8D92D3A1CD6AF422" modified="2011-05-03" version="1">MRRKTKETDIIVEIGVDGGIETGDRVFDHLLTALFFYMQQNVSIKASYDLRHHLWEDLGIVLGEELREKIKGRKIARFGSAIMPMDDALVLVAVDISRPYLNLELDIKESEKGFEVTLVREFLWALARTLNATIHMKQLAGVNAHHIIEAAFKGLGVALRQALSESERLESTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJH2</accession>
    <name>F0LJH2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF190 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0166 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466736.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00461"/>
    <dbReference type="EnsemblBacteria" id="ADT83438">
        <property type="protein sequence ID" value="ADT83438"/>
        <property type="gene ID" value="TERMP_00461"/>
    </dbReference>
    <dbReference type="GeneID" id="10040779"/>
    <dbReference type="KEGG" id="tba:TERMP_00461"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.461"/>
    <dbReference type="eggNOG" id="arCOG04967">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146749_0_1_2"/>
    <dbReference type="OMA" id="EHWNTLR"/>
    <dbReference type="OrthoDB" id="122737at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003793">
        <property type="entry name" value="DUF190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02641">
        <property type="entry name" value="DUF190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF190" evidence="2">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="126" mass="14325" checksum="CAE9E6CCA666B9EB" modified="2011-05-03" version="1">MVEVEHWNTLRLKIYIGENDSYKGKPLYKAIVERLREMGIAGATVYRGILGFGKKSKMHSADVLRLSTDLPIVIEAVDRGYKIEEAICKIKPMIKDGMITVEPVIVVWVGTEEEVRKFEDDAVRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJI6</accession>
    <name>F0LJI6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRISPR-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466750.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00475"/>
    <dbReference type="EnsemblBacteria" id="ADT83452">
        <property type="protein sequence ID" value="ADT83452"/>
        <property type="gene ID" value="TERMP_00475"/>
    </dbReference>
    <dbReference type="GeneID" id="10040793"/>
    <dbReference type="KEGG" id="tba:TERMP_00475"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.475"/>
    <dbReference type="eggNOG" id="arCOG03617">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054331_1_0_2"/>
    <dbReference type="OMA" id="WRIGLNE"/>
    <dbReference type="OrthoDB" id="53208at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010154">
        <property type="entry name" value="CRISPR-assoc_Cas7/Cst2/DevR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01905">
        <property type="entry name" value="DevR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01875">
        <property type="entry name" value="cas_MJ0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="316" mass="36035" checksum="6F82692049FCB8C3" modified="2011-05-03" version="1">MSEKVFEIAILGRALWELHSLNNEGNVGNVVEPRSVKIIDPNTGEAVTTDGISGEMLKHIHSEFMWLLDDKEYLCEACKVLHPERFNHVVNKNKSKFKSPKQVIEEAVKTCDICDVHGFMVEKPTVSRKSTVEFGWALGIPEVYRDIHLHARHAPGEKGKRQETEEGEREGGTQMIYHRPTRTGKYAIVTVFQPWRIGLNEARQDVYSYDGKRRKERYQLALKAYQLMFARPEGAMTTTRLPHVVDFEGVIVHSTKPVPVPVISPLKEDYKAEIKKIAETIEEIEVLEFKGVADFVEKIGTLLSKEPYEMNFGGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJJ7</accession>
    <name>F0LJJ7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00486"/>
    <dbReference type="EnsemblBacteria" id="ADT83463">
        <property type="protein sequence ID" value="ADT83463"/>
        <property type="gene ID" value="TERMP_00486"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00486"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.486"/>
    <dbReference type="eggNOG" id="arCOG05836">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1902044_0_0_2"/>
    <dbReference type="OMA" id="RRMDKHA"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038133">
        <property type="entry name" value="Ribo_III_sf_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021568">
        <property type="entry name" value="Ribonuclease_III_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11469">
        <property type="entry name" value="Ribonucleas_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="131" mass="14589" checksum="3F8987E9D29C6588" modified="2011-05-03" version="1">MPNMKYSKDFTDKNLSKFGDSLVNFIFSLALSEYLGYPSAGRVPNSSLALALERAKLSHLIPPRTDKHGKGDIAEAVIAYAWLEGKITVEEAAEIIKKNLSQDVLHFTRKKEVIGIAFGELLKVVKERLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJM8</accession>
    <name>F0LJM8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">atpB</name>
        <name evidence="11" type="ordered locus">TERMP_01695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467968.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01695"/>
    <dbReference type="EnsemblBacteria" id="ADT84670">
        <property type="protein sequence ID" value="ADT84670"/>
        <property type="gene ID" value="TERMP_01695"/>
    </dbReference>
    <dbReference type="GeneID" id="26137104"/>
    <dbReference type="KEGG" id="tba:TERMP_01695"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1694"/>
    <dbReference type="eggNOG" id="arCOG00865">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022916_0_0_2"/>
    <dbReference type="OMA" id="MLMMDSV"/>
    <dbReference type="OrthoDB" id="8899at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005724">
        <property type="entry name" value="ATPase_A1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01041">
        <property type="entry name" value="ATP_syn_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="10">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="9">
        <location>
            <begin position="132"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT84670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="462" mass="51867" checksum="979F2A7E02B022C6" modified="2011-05-03" version="1">MSGREYSTISKIYGPLMIVQGVKGVAYGEVVEIETESGERRKGQVLEAREDMAIVQVFEGTRDLDVKTTRVRFTGETLKVPVSMDMLGRVFSGIGKPIDGGPEIIPEDRRDVHGAPLNPVARAYPRDFIQTGISAIDGMNTLVRGQKLPIFSGSGLPHNQLAAQIARQAKVLGEEEQFAVVFAAMGITYEEANFFKKSFEETGAIERAVLFLNLADDPAIERIITPRMALTVAEYLAFDYDMQVLVILTDMTNYCEALREISAAREEVPGRRGYPGYLYTDLATIYERAGRVRGKKGSITQMPILTMPDDDITHPIPDLTGYITEGQIVLSRDLHRKGIYPPIDVLPSLSRLMKDGIGKGRTREDHPQLSQQLYAAYAEGRSLRDLVAVVGEEALSETDRKYLAFADRFEREFVAQAYDEDRSIEETLDLGWELLAMLPESELKRIEPKYIRKYHPKYRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJN2</accession>
    <name>F0LJN2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">V-ATPase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atpE</name>
        <name evidence="6" type="ordered locus">TERMP_01699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467972.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01699"/>
    <dbReference type="EnsemblBacteria" id="ADT84674">
        <property type="protein sequence ID" value="ADT84674"/>
        <property type="gene ID" value="TERMP_01699"/>
    </dbReference>
    <dbReference type="GeneID" id="10042015"/>
    <dbReference type="KEGG" id="tba:TERMP_01699"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1698"/>
    <dbReference type="eggNOG" id="arCOG00869">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105846_1_0_2"/>
    <dbReference type="OMA" id="YAGNIDC"/>
    <dbReference type="OrthoDB" id="93762at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="PTHR45715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="203" mass="23391" checksum="9ACB5D52E515E289" modified="2011-05-03" version="1">MEGAKLIIEEINREAEQKIRYILSEAEKQAEDIKAEAEKRARAKAEWILRKAQTQAEIEKQRIIANAKLEIRKKRLALQEEFINEVLRSLKERLANLPKDEYLGIVKDLMLQAVKELGEDRIRVSSNEATLQLIAEKLEEIKAFLNEKTGREIRIELGDKISTIGGVLVENADRTIRVDNTFEARIDRLESELRSRIAKVLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJR9</accession>
    <name>F0LJR9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease SbcD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468008.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01736"/>
    <dbReference type="EnsemblBacteria" id="ADT84711">
        <property type="protein sequence ID" value="ADT84711"/>
        <property type="gene ID" value="TERMP_01736"/>
    </dbReference>
    <dbReference type="GeneID" id="26137064"/>
    <dbReference type="KEGG" id="tba:TERMP_01736"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1735"/>
    <dbReference type="eggNOG" id="arCOG01150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075478_0_1_2"/>
    <dbReference type="OMA" id="IITKGNH"/>
    <dbReference type="OrthoDB" id="74433at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024173">
        <property type="entry name" value="Pesterase_MJ0037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000887">
        <property type="entry name" value="Pesterase_MJ0037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="20"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="217" mass="25044" checksum="109D8FB4A2406455" modified="2011-05-03" version="1">MEVERTFENLSIELETSRGKALVFADPHIAFELSRGLRIRTKFERKLAEFVKLKNPDFVIILGDIKEPLGINTFTKRLLLGFFSELRDFEVIITRGNHDGKIEEVLKNFENVKVVGYYTIDEMLFLHGHQILPPEAKFEKAFLGHIHPAVIIKFGSTAKRVKCFLRIEKFLILPTINPYIEGFDVREGIKMIPFLKNSKEGDAYLPEGTYIGRINFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJZ1</accession>
    <name>F0LJZ1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Diphthami_syn_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466826.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00551"/>
    <dbReference type="EnsemblBacteria" id="ADT83528">
        <property type="protein sequence ID" value="ADT83528"/>
        <property type="gene ID" value="TERMP_00551"/>
    </dbReference>
    <dbReference type="GeneID" id="26135906"/>
    <dbReference type="KEGG" id="tba:TERMP_00551"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.552"/>
    <dbReference type="eggNOG" id="arCOG00036">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010289_1_0_2"/>
    <dbReference type="OMA" id="EPLWGMD"/>
    <dbReference type="OrthoDB" id="101215at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="Alpha_ANH_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="PTHR12196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthami_syn_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="213" mass="24375" checksum="74DB2E204BF279F1" modified="2011-05-03" version="1">MRGVAFFSGGKDGLYATHLAERQGIEIPYLLALKTTIGISPHYENLSELKKLADAMNKKLLIFDMTKGSEGLAEFIASLDVDYIIAGDVLLEDHLKWVEWLAEKSGTRALEPLWGRDTLELAKEIINAGFEYSIIAVNKEKLSKEWLGYTFRSIGDLEKFLKENPNVDPVGEFAEFHTVVLKCPLFEKSFELKPEEVEEGERYWWLRFRLVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJZ8</accession>
    <name>F0LJZ8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0284 protein TERMP_00558</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0284 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00558"/>
    <dbReference type="EnsemblBacteria" id="ADT83535">
        <property type="protein sequence ID" value="ADT83535"/>
        <property type="gene ID" value="TERMP_00558"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00558"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.559"/>
    <dbReference type="eggNOG" id="arCOG04272">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053134_0_0_2"/>
    <dbReference type="OMA" id="TRWVAED"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01086">
        <property type="entry name" value="UPF0284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002805">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38811">
        <property type="entry name" value="PTHR38811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00303">
        <property type="entry name" value="TIGR00303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="333" mass="35922" checksum="9AB9AD89A04F8466" modified="2011-05-03" version="1">MMLVVLGNTEISTIPGISVAGATPELTKLTPPADAEYLFYEKPKIIDAIPVTPEGHPTPAIITKAAKELVDFPIVIVRGGTYLAPLVPHVHISDVVGRDFRREKALPEVEKIIENAKLFGEQLSKLNLREIVIGESTPGGTTTAQAVLWALGYDARTSSAAPSNPQSLKEQVIMEGFKRAGIEKGGFADEPLKALEEFGDPMMATVIGLSQGFKGNVVLAGGTQMLAIAALLKAKGEDLSRFMIATTKWVVNDESSTFKKTAKDIGIIYYYAELDFSKSRFKGLQDYERGYVKEGVGAGGAVWLAVKKGFTAEDVAKKVDELYERLMEIGGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK55</accession>
    <name>F0LK55_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Archaeosine tRNA-ribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; archaeosine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeosine synthase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468063.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01792"/>
    <dbReference type="EnsemblBacteria" id="ADT84767">
        <property type="protein sequence ID" value="ADT84767"/>
        <property type="gene ID" value="TERMP_01792"/>
    </dbReference>
    <dbReference type="GeneID" id="10042108"/>
    <dbReference type="KEGG" id="tba:TERMP_01792"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1791"/>
    <dbReference type="eggNOG" id="arCOG00990">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029831_0_0_2"/>
    <dbReference type="OMA" id="YPAAHYD"/>
    <dbReference type="OrthoDB" id="21064at2157"/>
    <dbReference type="UniPathway" id="UPA00393"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040777">
        <property type="entry name" value="DUF5591"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029402">
        <property type="entry name" value="TGT_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038250">
        <property type="entry name" value="TGT_C2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17884">
        <property type="entry name" value="DUF5591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14810">
        <property type="entry name" value="TGT_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="503"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="569" mass="65268" checksum="4319647159DF054F" modified="2011-05-03" version="1">MEILKHEGPGRLGLVRLKDKSFRTPALVNVDFTLSPFNSYFYPKAFSEYDFNLAPSIPISFYTPSEIVEKAFSRLIGVDYSNFNAFYLPAIRDVERLEKFLDEILANNSFDALYLGNSKVLVKDYRRFVQTLRMIREKDPNLMIITDLEPFFYPLAVYLGIDAFDTRSLKLYDFHKKSFTMYSPLLWDEGENSLEFAEKVISLVRKALEEGKLRYLVENFFYTQSHAGILRIADKEHGDYLEKYTPIQKDTVYFISDASQNRPEVKRWHQRVIERFVPPKAKLLLLFPCSAKKPYSRSRSHTLYRKALQEVLGSGIYKVHELILTSPFGVVPREWEWLAKYDIVVTGHWSEEEISSAAELLAKTLEKYPDIPIVAHLDEAYVEIAKRASEMSGKEIIFVPVKNGTTSRESIAALKKTLEELGLDLKAGKEDRTYRFYENIRKIFDFYFGIGAGDAVLPDDAQIKGSRMLRIFVDGRQTGTFQDGVISVTPYGMQRIYEATKSYYVRIDFDLRGDVFAVGVSEADEKIRPDDLVAVVRDEQVVAVGKALLSGEEMVKAKRGVAVKVKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK72</accession>
    <name>F0LK72_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468080.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01809"/>
    <dbReference type="EnsemblBacteria" id="ADT84784">
        <property type="protein sequence ID" value="ADT84784"/>
        <property type="gene ID" value="TERMP_01809"/>
    </dbReference>
    <dbReference type="GeneID" id="26137325"/>
    <dbReference type="KEGG" id="tba:TERMP_01809"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1808"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_2_2_2"/>
    <dbReference type="OMA" id="PLFGEYD"/>
    <dbReference type="OrthoDB" id="125556at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="75" mass="8575" checksum="DBD8A13696E0B670" modified="2011-05-03" version="1">MIAFILITTKTGKENEVAKNLKKISKVKEVYTLYGNYDVIAKVEVENLQRLNELGNEILKENKGILYTETLICAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK89</accession>
    <name>F0LK89_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH asnC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468097.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84801">
        <property type="protein sequence ID" value="ADT84801"/>
        <property type="gene ID" value="TERMP_01826"/>
    </dbReference>
    <dbReference type="GeneID" id="10042142"/>
    <dbReference type="KEGG" id="tba:TERMP_01826"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1825"/>
    <dbReference type="eggNOG" id="arCOG05868">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_898983_0_0_2"/>
    <dbReference type="OMA" id="DYEYYEV"/>
    <dbReference type="OrthoDB" id="39992at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="1">
        <location>
            <begin position="155"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="300" mass="35150" checksum="F97036FC4485D086" modified="2011-05-03" version="1">MSEVKIEEVEYLAEILEKSPRESLLKIAKREGIDYYKLKRLYNKYYGKYVHVSAIYDIAKLGLKSYVAFLSVPREEIRRVASEMSKNPFIPSIAAIFGFKNGISAVLHVPKDQTGLIDELLSRYSDDYEYYEVRAYPEKPKEFGEWNLSYDYAVLMDILKYDARTSPTKMSEILGKSRPTIRYMIKRLEETGIIRRYSALVDMTAYDRGFCGIADELSEKLLEKFKNYEILIGVLKPQGYLIEWYFSSKEDIGAKIFEFSRYVKKFAIYYFDLLEGIEPSYRFAERVKKDGSGYRSILEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK92</accession>
    <name>F0LK92_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="5">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468100.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01829"/>
    <dbReference type="EnsemblBacteria" id="ADT84804">
        <property type="protein sequence ID" value="ADT84804"/>
        <property type="gene ID" value="TERMP_01829"/>
    </dbReference>
    <dbReference type="GeneID" id="26137343"/>
    <dbReference type="KEGG" id="tba:TERMP_01829"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1828"/>
    <dbReference type="eggNOG" id="arCOG04184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_1_0_2"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="OrthoDB" id="94889at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <begin position="7"/>
            <end position="12"/>
        </location>
    </feature>
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        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="167"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="184" mass="21055" checksum="59FF572A84A77DC0" modified="2011-05-03" version="1">MKIVFITSNKGKVKEAQKYFDSIGVNIVQQKIEYPEIQAKELEEVVKFAIEWLKDKIDKPFFIDDSGLFIEALNGFPGVYSAYVFKTLGNEGILKLMEGVKNRKAYFKSVIGYYDGEIHIFKGIVNGRIGYTKRGNLGFGFDPIFIPEGFTKTFAEMTTEEKNKISHRGRALEAFSKWLKENLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKA9</accession>
    <name>F0LKA9_THEBM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="ADT83567">
        <property type="protein sequence ID" value="ADT83567"/>
        <property type="gene ID" value="TERMP_00590"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00590"/>
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    <dbReference type="eggNOG" id="arCOG01996">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="93" mass="10415" checksum="440748CC35236059" modified="2011-05-03" version="1">MFYAYLNLGELKTFFLLILPHGIFEIPAIIIAGAAGFKIPYELLRFALGKKEEIISEEDAKEFFKLFLISMILIFIAALIESTITAKIAESLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKB2</accession>
    <name>F0LKB2_THEBM</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ADT83570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT83570">
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    </dbReference>
    <dbReference type="GeneID" id="10040911"/>
    <dbReference type="KEGG" id="tba:TERMP_00593"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.594"/>
    <dbReference type="eggNOG" id="arCOG02436">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068384_1_0_2"/>
    <dbReference type="OMA" id="WCKTEIE"/>
    <dbReference type="OrthoDB" id="68949at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="323" mass="35822" checksum="94FE6CA05B3FF8E8" modified="2011-05-03" version="1">MKAINIAMKDFEVSIRTRKFQIIIALFTIISLGMIYSSKRLGISANLYKTPFQMLFLSSFSNAFNYSIASLGILLGATAINEEIEKGTLKLVASKPVYRDEIIAGKLLGGLLTLSVALALFYILTVAFALILGVLITGDDLMKFLATFPFSTLYGLVFLSLGLLVSTLIKKSKNALIMSIFLFVFFGFLLSIIAGVVAFAVAGLPPVPNIPENATNLSDEQLQEIFLKDQAYQAWLTKLTITAEKILYISPNYHYQEIIRILFGGKPQISDIVSALAYEQSVVEERSIVESLGLVWENITALLIMFIFPFAMAYVRFMKADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKB4</accession>
    <name>F0LKB4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466870.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00595"/>
    <dbReference type="EnsemblBacteria" id="ADT83572">
        <property type="protein sequence ID" value="ADT83572"/>
        <property type="gene ID" value="TERMP_00595"/>
    </dbReference>
    <dbReference type="GeneID" id="10040913"/>
    <dbReference type="KEGG" id="tba:TERMP_00595"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.596"/>
    <dbReference type="eggNOG" id="arCOG02436">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068384_1_0_2"/>
    <dbReference type="OMA" id="HSRKDVL"/>
    <dbReference type="OrthoDB" id="68949at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="305" mass="33413" checksum="F1A3EAA1F789F49E" modified="2011-05-03" version="1">MNPILNVAIKDLQESIKTKRLAITLAIFILAGIGMAYWLKSVMMNVPFSSGDEQFLSRAIRGNLLSTAKNFLAIFSMLIGADAINREIESGTIKVTLGHPIYRDQFILGKLLGRAVTVMFGFAIFSVVSTASMLIIGIPLNTDILLTFIKPLPFFVLFSLVYLSLGVLLSTAIKKPSTAIIVAIILPIFLEMVYPMVVSMVIAIKAFASGGASPQAIQEIVRKVQTFLMIQPGFHMENINNAIFYGMTSSQIATSGVAFQVSPQISGVSYVEALSLAWKNIVLLFVMMLIPFALAYLRFMKADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKD0</accession>
    <name>F0LKD0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxoglutarate oxidoreductase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of one alpha, one beta, one delta and one gamma chain.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466886.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00611"/>
    <dbReference type="EnsemblBacteria" id="ADT83588">
        <property type="protein sequence ID" value="ADT83588"/>
        <property type="gene ID" value="TERMP_00611"/>
    </dbReference>
    <dbReference type="GeneID" id="10040929"/>
    <dbReference type="KEGG" id="tba:TERMP_00611"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.613"/>
    <dbReference type="eggNOG" id="arCOG01607">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_0_1_2"/>
    <dbReference type="OMA" id="DFFQARW"/>
    <dbReference type="OrthoDB" id="34838at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="2">
        <location>
            <begin position="34"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="3">
        <location>
            <begin position="295"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="395" mass="44052" checksum="11C55C74AB280B7E" modified="2011-05-03" version="1">MIIQGDEPEQIRLLRKLYPKGNYFMQGDEAIAYGAIFAGCRFYAGYPITPASEIAETMARELPKVKGYYIQMEDEIGSIAAIIGASWTGLKSMTATSGPGFSLMQENLGYAIMTETPIVVVDVQRSGPSTGQATKGAQGDFFQARWGTHGDHPIVAISPISVEDSFWETIRAFNISEKLRIPVILLADGIIGHTREQIRIPDPEEVEIVYRKLPKDEEEAKYPFGDVDGSLVPPMPLFGHGYFTHVTGSTHKETGLRDVYTPEVHIKLVNRLHKKIEKHEKEIEKWEEYFTDDMEILVISWGVSARPSLGAVLKAREEGIKVGLFIPKTVHPFPGKKVKDLAKKVRAIIVPEMNLGQLILEVQRYVNDDVILKGVNKIGGIPLTVEEILREIRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKG6</accession>
    <name>F0LKG6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="10" type="ordered locus">TERMP_00647</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466922.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00647"/>
    <dbReference type="EnsemblBacteria" id="ADT83624">
        <property type="protein sequence ID" value="ADT83624"/>
        <property type="gene ID" value="TERMP_00647"/>
    </dbReference>
    <dbReference type="GeneID" id="26136047"/>
    <dbReference type="KEGG" id="tba:TERMP_00647"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.649"/>
    <dbReference type="eggNOG" id="arCOG04172">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_5_1_2"/>
    <dbReference type="OMA" id="QAIKLSM"/>
    <dbReference type="OrthoDB" id="65776at2157"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="291" mass="32514" checksum="3E694AD48976BD77" modified="2011-05-03" version="1">MIEGIYVPHVTPFDDNENINEEALRELIHYFENARVSGFVTLGSNGEFPYLNFEEKMRVLKIVCEETNLPVIAGVTENSTRETVKLAKEAWNLGVDALLIAPPYYFKPNEKELFAHYSAIAQSVEAPILIYNVPKFTGINIPIQVIEHLVEEYSNIIGIKDSSGSIGRIGELIRRLGEDMSILAGTADLIYPALALGAHGAVIAVANVAPRLCVELYTAFLEKKYERAKRLQLMINYLNEILVKRYNQISAIKEAMNMLGLNVGYPRMPSLLLDEQAVQEIEFALAEVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKH0</accession>
    <name>F0LKH0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466926.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00651"/>
    <dbReference type="EnsemblBacteria" id="ADT83628">
        <property type="protein sequence ID" value="ADT83628"/>
        <property type="gene ID" value="TERMP_00651"/>
    </dbReference>
    <dbReference type="GeneID" id="10040969"/>
    <dbReference type="KEGG" id="tba:TERMP_00651"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.653"/>
    <dbReference type="eggNOG" id="arCOG03004">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141446_2_0_2"/>
    <dbReference type="OMA" id="MIIMPAN"/>
    <dbReference type="OrthoDB" id="105481at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="47"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="106" mass="11894" checksum="13711015495457C6" modified="2011-05-03" version="1">MNAHPKVKKLKDMVEYQEGAVVSRTIIDKKTGTVTVFAFDKDQGLSEHTAPFDALVYILEGKAEVVISGKSYYLEEGDMIVMPANEPHALKAVDKFKMFLVMIKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKJ7</accession>
    <name>F0LKJ7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468127.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01856"/>
    <dbReference type="EnsemblBacteria" id="ADT84831">
        <property type="protein sequence ID" value="ADT84831"/>
        <property type="gene ID" value="TERMP_01856"/>
    </dbReference>
    <dbReference type="GeneID" id="10042172"/>
    <dbReference type="KEGG" id="tba:TERMP_01856"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1855"/>
    <dbReference type="HOGENOM" id="CLU_1324073_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="207" mass="23912" checksum="F4DBAEFA8165C6D4" modified="2011-05-03" version="1">MNRTNNRELNVFSFFVAVASIIATLVYQLINKEERELAREYALVAVYALFMAMSFALSYYYGDDSSKDNKLDSDLRIIAGAFLDGFLVTSLFVVVVEFLRQSFSNTVFTCALSFVIVLWFGCVLLSLYGKLDKSTISHYLSREYLLRICFIIFVALALIYYCNYPLIGTFLLAFFMKLTIDGYWEFKQTDIKDSRDKPNKDELESQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKJ9</accession>
    <name>F0LKJ9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TATA-box binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01858"/>
    <dbReference type="EnsemblBacteria" id="ADT84833">
        <property type="protein sequence ID" value="ADT84833"/>
        <property type="gene ID" value="TERMP_01858"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01858"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1857"/>
    <dbReference type="eggNOG" id="arCOG01764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060161_4_3_2"/>
    <dbReference type="OMA" id="CCTYEPE"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="PTHR10126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="174" mass="19763" checksum="E9E8DCB0D1C29FB2" modified="2011-05-03" version="1">MLIAMEYKIVNIVVSGHLGSQINLEKLLELDNFSYDPEYYHGGYLRLSNGLSVTIYRTGKYIIPGVKRLEDIEPSFDEMIRYLSKLIDVSNAEKPKIRNLVISGKLEEKLSLEELAIKLPNVEYDPEQFPGLILKFNKSLTVLLFNSGRFVVVGAKSLEEAENAIKKLKKLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKK7</accession>
    <name>F0LKK7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468137.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01866"/>
    <dbReference type="EnsemblBacteria" id="ADT84841">
        <property type="protein sequence ID" value="ADT84841"/>
        <property type="gene ID" value="TERMP_01866"/>
    </dbReference>
    <dbReference type="GeneID" id="10042182"/>
    <dbReference type="KEGG" id="tba:TERMP_01866"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1865"/>
    <dbReference type="eggNOG" id="arCOG01241">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_741069_0_0_2"/>
    <dbReference type="OMA" id="MASETIW"/>
    <dbReference type="OrthoDB" id="78666at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="418" mass="48787" checksum="2EBB6CFD79A4F913" modified="2011-05-03" version="1">MASETIWLRYKGNNVKYKFTSEDIEELLADHTKELSESSRKEIERYIWQFLHFTKTGELVKGKNPKAPEKVEVYEISEDILREYVDALSRAGYGESAKLKRMRYVKMMLRLLGAPAKVIEVLDAPLRKTKDAWIAKLEDDTPDVTIEDAREFFARLEKLFESGKLSESRYVKAVVFALLLFSTGRRVSEVAQTTVDMINIKLHQVKFDASKTKEGRLRNATGYFKIAFLTREAELALKFYLTKYGKEIEDRGGYLFIHQNKKYFKDTFLHKIIKENREIMKFEVSDGIHEFELKFFRKIFAQEWRRQAEAKGIANDRVLTAGRKIMGHSPVRDVHNMHYDALRISELWKYYKQIYYDLRVLTPKQRKLFGIDEGGSCKRVATPNRDYGIVASYYQIIAGSLIVPRKSQLAMNYLIIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKL7</accession>
    <name>F0LKL7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">DNA repair and recombination protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">radA</name>
        <name evidence="10" type="ordered locus">TERMP_01876</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the eukaryotic RecA-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468147.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01876"/>
    <dbReference type="EnsemblBacteria" id="ADT84851">
        <property type="protein sequence ID" value="ADT84851"/>
        <property type="gene ID" value="TERMP_01876"/>
    </dbReference>
    <dbReference type="GeneID" id="10042192"/>
    <dbReference type="KEGG" id="tba:TERMP_01876"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1875"/>
    <dbReference type="eggNOG" id="arCOG00415">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_0_0_2"/>
    <dbReference type="OMA" id="TFRIYLR"/>
    <dbReference type="OrthoDB" id="30130at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01123">
        <property type="entry name" value="Rad51_DMC1_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00348">
        <property type="entry name" value="RadA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011938">
        <property type="entry name" value="DNA_recomb/repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033925">
        <property type="entry name" value="Rad51_DMC1_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02236">
        <property type="entry name" value="recomb_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="8">
        <location>
            <begin position="115"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="9">
        <location>
            <begin position="296"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="144"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT84851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="355" mass="39283" checksum="5B0547C8B4871F00" modified="2011-05-03" version="1">MARKKKVETVDDEIKELEEFEELSIDAEVAKTSKKKKKEIKTLEDLPGVGPATAEKLREAGYDSLEAIAVASPIELKEIAGISEGAALKIIQAAREAANIGTFIRADEYFQRRQTIGRISTGSKSLDKLLGGGIETQAITEVFGEFGSGKTQIAHTLAVMVQLPPEEGGLNGSVIWIDTENTFRPERIRQIAENRGLDPDEVLKNIYVARAYNTNHQMLLVEKAEEIIKEKLNTDRPVKLMVVDSLTSHFRSEYVGRGALAERQQKLGKHLADLHRLANLYDIAIFVTNQVQARPDAFFGDPTRPIGGHILAHSATLRIYLRKGKAGKRIARLIDSPHLPEGEAAFRITDKGIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKV0</accession>
    <name>F0LKV0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466977.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00702"/>
    <dbReference type="EnsemblBacteria" id="ADT83679">
        <property type="protein sequence ID" value="ADT83679"/>
        <property type="gene ID" value="TERMP_00702"/>
    </dbReference>
    <dbReference type="GeneID" id="10041020"/>
    <dbReference type="KEGG" id="tba:TERMP_00702"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.703"/>
    <dbReference type="eggNOG" id="arCOG00950">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736956_0_0_2"/>
    <dbReference type="OMA" id="MYELTED"/>
    <dbReference type="OrthoDB" id="26127at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007549">
        <property type="entry name" value="DUF512"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045375">
        <property type="entry name" value="Put_radical_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04459">
        <property type="entry name" value="DUF512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19238">
        <property type="entry name" value="Radical_SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical_SAM_2" evidence="2">
        <location>
            <begin position="36"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="DUF512" evidence="1">
        <location>
            <begin position="243"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="354" mass="40649" checksum="061FE7121BCB8EB8" modified="2011-05-03" version="1">MYELTEDYKLRKITKFELDMVDERDDLLIIPPSSKAGPCGNDCVFCYLTQNPPQMIYRVAKHDTLNDPELERRVAYAREHYDLWIRVTDTSANVRFDENRIESLYNAGLDEIQISLHTTKKDVRIKLMHNRNAGKVIDLIPKIVEHFRMIADIILTPGYNVSDIGKILDDLDSFGVHEVRLFPVGVTRFSKTRALTREELLFVKSVALEKQKDLGIEIVIPPIFQALLGEFTTGLEPFDIEMNIPTYILTGELAYPEMKRLFPKLNVVMVRNEVFGGNIGTAGLLTGYDVLRAIKQLPEVDLGILLLPEVMFHGDITLDGWKREELFNRILIEKGYIVETALEPQEIPKILERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL09</accession>
    <name>F0LL09_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01941"/>
    <dbReference type="EnsemblBacteria" id="ADT84916">
        <property type="protein sequence ID" value="ADT84916"/>
        <property type="gene ID" value="TERMP_01941"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01941"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1940"/>
    <dbReference type="eggNOG" id="arCOG02291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1202655_0_0_2"/>
    <dbReference type="OMA" id="DTLCNTW"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="229" mass="27145" checksum="C1E823C11B1E855A" modified="2011-05-03" version="1">MVDLDDTLCNTWEAGKYTIIRLFPHLLRKRKFKALFYILTARYRELEQSRELLVLDLDKLLQRIMERVYSRVKREDLEEMLELVDRTFFSNLKLFPDAKYFLEELKKINAKLVLVTDSSTYWQRKKLEYLGIKDYFDGIIISGETGHSKLDPHNFLLARRMFPNEDEVYMVGDRDDTDMKGGKAVGAITILVKRGYFKGKRAKYADYVVKDLIEALEVIKREHEKRDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL72</accession>
    <name>F0LL72_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467021.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00746"/>
    <dbReference type="EnsemblBacteria" id="ADT83723">
        <property type="protein sequence ID" value="ADT83723"/>
        <property type="gene ID" value="TERMP_00746"/>
    </dbReference>
    <dbReference type="GeneID" id="10041064"/>
    <dbReference type="KEGG" id="tba:TERMP_00746"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.748"/>
    <dbReference type="eggNOG" id="arCOG01875">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1088213_0_0_2"/>
    <dbReference type="OMA" id="GHHRWAG"/>
    <dbReference type="OrthoDB" id="76894at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040867">
        <property type="entry name" value="DUF5603"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023098">
        <property type="entry name" value="SerK/SbnI_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18231">
        <property type="entry name" value="DUF5603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="243" mass="27719" checksum="8A4247B9CB753956" modified="2011-05-03" version="1">MGVEKVPKYDIPVKKVEYVFIELEKMKPHEQLVQKELEAFIESVTGSGVFWKPMLLAKVPGEDMYLIVDGHHRWAGLMKLGAKKAPSVILDYFSDDVKVYTWYPAFKGDLGKVLERLKKEGLTVEECEDAEELAEKGEIAFALVGKDKAFKILGGLKEQKIVSKVLDEMSVEGEIELIYYGLKEDAKEDMDKGEIDYVFIRKAPSKEEVMELVKRGEVFSPKTTRHVLPFIPDKIDVKLEDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL76</accession>
    <name>F0LL76_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467025.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00750"/>
    <dbReference type="EnsemblBacteria" id="ADT83727">
        <property type="protein sequence ID" value="ADT83727"/>
        <property type="gene ID" value="TERMP_00750"/>
    </dbReference>
    <dbReference type="GeneID" id="10041068"/>
    <dbReference type="KEGG" id="tba:TERMP_00750"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.752"/>
    <dbReference type="eggNOG" id="arCOG03270">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_399907_0_0_2"/>
    <dbReference type="OMA" id="DPLGNWH"/>
    <dbReference type="OrthoDB" id="10325at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="682" mass="76378" checksum="185FCF75A82C281B" modified="2011-05-03" version="1">MRRMALMLIGLLFLSTAPAVKSVSVPEYAGLSLIELGLKDSVVFGIYEIKFTDVDPYWTKAALDIYENGVKKATAVLGLGDSYYYPSSTNPLLRITLKWTQADRKTILIAIDSPLIKIASDVRLDEGDSYTLPAGFPSIKIKLVDAYDTSAKFTVYLPYTTLTKTVNENDGFGVAYKLTDEVSYYPYVFVFLKSSVKNSYATVDIYVPKYAATKLEIKKATAKETPTETKVEPTELVYDDILYVGEILTINYNSTIYKLRLNSIGYYSSLSLFDKNNKPLETFSVKEGGSYTSKKAPIRVEIPPNSVDLTYNRTYIKVYAPSGAEVPPIVREAKIKVDLSTNAKEMLLNSEELIVFVNVENQGRGKAFDVKVMAPLPNNFELKSGIGTWSLKTLDAFTKMPVLVYTLKPTQVGRYDLGKVKVEYYNEAGQKKVISSNEVKGIVVYSIPEISLSAEAFNGTWSNYITTQEKSIKLRFKVSAGKGNPEFEFIKNATLELILPDSIDGETTIKLGDIKAGEEKIVEGQYVVLKQAVSIIGAKLKYQDPLGNWHEEYFGNLLIINSIPPKVIVEEKVQKVYPKPEELPDYIKKTLDTLKDPTPLAQAIENITVSYLPKKPDYKTPLIVILLVLVVALGAATVNYRNKYEIVRSKLERRKKRPGGLPKKEEEEQEVKTPEFKKEESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL97</accession>
    <name>F0LL97_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00771"/>
    <dbReference type="EnsemblBacteria" id="ADT83748">
        <property type="protein sequence ID" value="ADT83748"/>
        <property type="gene ID" value="TERMP_00771"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00771"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.773"/>
    <dbReference type="eggNOG" id="arCOG00899">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048072_1_1_2"/>
    <dbReference type="OMA" id="EILRITW"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="270" mass="29838" checksum="CFDC154E879A42AC" modified="2011-05-03" version="1">MIGIAVALYYLSALIYALRWKVVLNAIGKNIPIIELLRITLSSIFVNNVTPMSRGGGEILRITWVAKKYKIPVAISTVSIVYERILEIFPIIFLAVMGISYFAHHAILIILSLFLVAVIVWLNWEKIVILSFKLLKIKLSHEELVNLLSLRKRASLTMMGVGLSFLVWFLDIMRLKVIALAFSWNPSIKFLAIISLANLIFGLMAFTPGGIGIVEGGLIGTLVYFGIPSTLAISITLIERFISYVMSSAVGFATLVVSGGAEIWKALKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLE9</accession>
    <name>F0LLE9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84978">
        <property type="protein sequence ID" value="ADT84978"/>
        <property type="gene ID" value="TERMP_02004"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02004"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2001"/>
    <dbReference type="eggNOG" id="arCOG01118">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143279_0_0_2"/>
    <dbReference type="OMA" id="MRVYTVY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="154" mass="17683" checksum="562DAB7C7AC86583" modified="2011-05-03" version="1">MEEKVSLTTRQIELLRKLYKEGKTIEVHTVEKTQDELAEELGITRQALSNHLKVLKELGYIRTGRGFIDLTGKALELLGERKGDVFVFVKIEPTKRKHVYDAIRKLKVRRIYRVTGDIDLIVEADKTKLDEILEEIASLDGVKETITHVVLETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLF4</accession>
    <name>F0LLF4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="8">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">aIF2-gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">eIF-2-gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eif2g</name>
        <name evidence="10" type="ordered locus">TERMP_02009</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimer composed of an alpha, a beta and a gamma chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468279.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02009"/>
    <dbReference type="EnsemblBacteria" id="ADT84983">
        <property type="protein sequence ID" value="ADT84983"/>
        <property type="gene ID" value="TERMP_02009"/>
    </dbReference>
    <dbReference type="GeneID" id="10042324"/>
    <dbReference type="KEGG" id="tba:TERMP_02009"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2006"/>
    <dbReference type="eggNOG" id="arCOG01563">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027154_0_1_2"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="OrthoDB" id="25592at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00119">
        <property type="entry name" value="eIF_2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
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        <property type="entry name" value="TIF2_gsu"/>
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        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
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        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03680">
        <property type="entry name" value="eif2g_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="8"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="24"/>
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        <ligand>
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            <label>1</label>
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        <location>
            <position position="45"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
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    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT84983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="410" mass="44862" checksum="677E351A90E36538" modified="2011-05-03" version="1">MAKKKFKQSEVNIGMVGHVDHGKTTLTKALTGIWTDTHSEELRRGITIKIGFADAEIRRCPSCGRYSTSPICPYCGAETEFERRVSFIDSPGHEALMTTMLAGASLMDGAILVIAANEPCPRPQTREHLMALQIIGNKNIIIAQNKIELVDKEKALENYRQIKEFIKGTVAENAPIIPISALHGANVDVLIKAIEDFIPTPKRDPNKPPKMLVLRSFDVNKPGTPPEKLIGGVIGGSIVQGKLKVGDEIEIRPGVPYEEHGRIKYEPITTEIVSLQAGGRFVEEAYPGGLVGVGTKLDPFLTKGDLMAGNVVGKPGKLPPVWEELRLEVHLLERVVGTEQELKVEPIKKREVLLLNVGTARTMGLVTGLGKDEIELKLQIPVCAEVGERVAISRQVGSRWRLIGYGFIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLG8</accession>
    <name>F0LLG8_THEBM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">TERMP_02023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
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    <dbReference type="EnsemblBacteria" id="ADT84997">
        <property type="protein sequence ID" value="ADT84997"/>
        <property type="gene ID" value="TERMP_02023"/>
    </dbReference>
    <dbReference type="GeneID" id="10042338"/>
    <dbReference type="KEGG" id="tba:TERMP_02023"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2020"/>
    <dbReference type="eggNOG" id="arCOG03822">
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    <dbReference type="OMA" id="LATQINI"/>
    <dbReference type="OrthoDB" id="94663at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Class3_signal_pept_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04021">
        <property type="entry name" value="Class_IIIsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="203" mass="21969" checksum="9837D97C3756E7DA" modified="2011-05-03" version="1">MKKAQISLEFMLIFGILLILLAYSINNITFSQKSQSNELLRVQVSLEAKSLANSISNTISQVYAQGPGSKATSYITLRYLRDENYLKKSFNLSGSPEIFITYLNGTYVGIVDTANNSLVTSGAGKNTFWSQSLYRTDLTGSAGFTPSGTAIYNGNIVNGILIANPAQLPTTLVIIVEWIPGNGNTWVLDMTAGELRITIDPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLK5</accession>
    <name>F0LLK5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02060"/>
    <dbReference type="EnsemblBacteria" id="ADT85034">
        <property type="protein sequence ID" value="ADT85034"/>
        <property type="gene ID" value="TERMP_02060"/>
    </dbReference>
    <dbReference type="GeneID" id="10042375"/>
    <dbReference type="KEGG" id="tba:TERMP_02060"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2057"/>
    <dbReference type="eggNOG" id="arCOG01377">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024306_0_0_2"/>
    <dbReference type="OMA" id="IPGRFYI"/>
    <dbReference type="OrthoDB" id="6644at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="467" mass="54273" checksum="7C67E0055033B273" modified="2011-05-03" version="1">MNEMLENVKKVFVIGLDSAPPELLFNRFLDELPNIKWLVERSIYGPMKSTIPAITIPAWMVMATGKTPGELGLYGFRHRKKGTYNDIWIAHSLMVKEKAVWHYITEKGKKSVLVGIPPSYPPKPVNGWLISCFITPDASVDYTYPKELKGEIERLVGEYIFDVVFRKENRDEVKEQLWEMTEKRFEVIRYLIQEKDWDYFEFVEIGLDRVHHAFWKYFDENHHLYPGNDNPYKNVIPDYYKLLDKEIGKTLKLLDLDETAVIIVSDHGIKAMKGAFAINQWLIEEGLLKIKNPEILKEGRQVRFNELKVDWSKTIAWAWGGYYSRVFLNVKGREPMGIIEPERYYQVRDEVAELIKSIRGPNGEKWNTKVFYPEEIYPVAKGDKPDMMVYLDDLNWRAAGTLGYESPYLLENDLGPDDAVHAEYGVFSLYLPGMSEAKRTQLTIYDFAPTVLKLFGMKKPLIGRSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLM4</accession>
    <name>F0LLM4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467099.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00824"/>
    <dbReference type="EnsemblBacteria" id="ADT83801">
        <property type="protein sequence ID" value="ADT83801"/>
        <property type="gene ID" value="TERMP_00824"/>
    </dbReference>
    <dbReference type="GeneID" id="10041142"/>
    <dbReference type="KEGG" id="tba:TERMP_00824"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.826"/>
    <dbReference type="eggNOG" id="arCOG06948">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_838416_0_0_2"/>
    <dbReference type="OMA" id="DTNLFYH"/>
    <dbReference type="OrthoDB" id="29231at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="110"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="332" mass="38974" checksum="A17EEACC11CC9465" modified="2011-05-03" version="1">MEIIIDKPEVQILLNLLPDDAVVSYPLYGNFPLLKFRREGYGYGIEALTQPEDFSRILSEKKDSFHDLPTYRDFHECVLASGILKYSNLDDFEKHLESYALLSKRVIFALDTNIFYHRFVSSYIPLQRYELAVVDVVIWEIEQSMNYKYHLGHINALKRILPNSYLLDEFHNRRMKKSRKAAYIALKEFKALKDRIIEVRRVHEESGTNDELIVKSLKQFDKETPSLVVLLTADIAMTDIAELEGVEYFLFEYPHEKISTHHATPYQMRTLLFNLAAVFGVIRVEDVLIFGEFGGKVKLNDLKLKFLKNSIYHEFTFHLKLSRKLKELKIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLN9</accession>
    <name>F0LLN9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IscU/NifU-like Fe-S cluster assembly scaffold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467114.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00839"/>
    <dbReference type="EnsemblBacteria" id="ADT83816">
        <property type="protein sequence ID" value="ADT83816"/>
        <property type="gene ID" value="TERMP_00839"/>
    </dbReference>
    <dbReference type="GeneID" id="10041157"/>
    <dbReference type="KEGG" id="tba:TERMP_00839"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.842"/>
    <dbReference type="eggNOG" id="arCOG02077">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1302638_0_0_2"/>
    <dbReference type="OMA" id="LKHVMNP"/>
    <dbReference type="OrthoDB" id="89731at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="17"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="216" mass="24287" checksum="593041E9043D67B3" modified="2011-05-03" version="1">MERFDGRKWDEKKRIGYSRKVLYYFLHPKNVGEIENPSVTAKAGSPACGDMIKLYLKIENDKIVDAKFRSYGCAANIATASVLTEMIIGKTVEEAKKIKFKDIVEELGGLPQIKYHCAVLAAEGLKQALAKWDVITGKRQIDEKFVKLILAAVIDPLTGESVLRGDKYKGCKIEGRKVKIMLNIPKDSPEAEVFEEQIREAFEGLDVDLEIEFTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLS8</accession>
    <name>F0LLS8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467153.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00878"/>
    <dbReference type="EnsemblBacteria" id="ADT83855">
        <property type="protein sequence ID" value="ADT83855"/>
        <property type="gene ID" value="TERMP_00878"/>
    </dbReference>
    <dbReference type="GeneID" id="10041196"/>
    <dbReference type="KEGG" id="tba:TERMP_00878"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.881"/>
    <dbReference type="eggNOG" id="arCOG05792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1493033_0_0_2"/>
    <dbReference type="OMA" id="YVRENAM"/>
    <dbReference type="OrthoDB" id="103861at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="188" mass="21654" checksum="8A2217D919DA0304" modified="2011-05-03" version="1">MGLFSFGSKKDKVRKMLETNQIEAVVEQALKDRKVINALFELLNEKNPGIVGDSLLALTNILERDKNLIIRNLRIEHFLKSFDLVKSRNSYVKENAMVFLSFLIKENPSLFTEFKNDVIAKTKDVLLSGDKNDKAFALLMIREFRIAELRPYVEELISVQEKVILPFEGMKWVPLGEIAKDVLRRLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLW5</accession>
    <name>F0LLW5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468360.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02090"/>
    <dbReference type="EnsemblBacteria" id="ADT85064">
        <property type="protein sequence ID" value="ADT85064"/>
        <property type="gene ID" value="TERMP_02090"/>
    </dbReference>
    <dbReference type="GeneID" id="10042405"/>
    <dbReference type="KEGG" id="tba:TERMP_02090"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2087"/>
    <dbReference type="eggNOG" id="arCOG03169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061108_0_0_2"/>
    <dbReference type="OMA" id="QYLRFSN"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="352" mass="40594" checksum="B8E6B51230393E86" modified="2011-05-03" version="1">MLFSRIKKSRNEMFDREYEFDKIVSAIKDGVPLIVVTGIRRVGKTTLVKVLLNEIDTPGVYIDARKLWSTHANISPNVIKKEILKSLNARKSYAPVMRLLKSLKSVTIAGSGVEFKDKNTDLIDVLDDIENSGERAVIIFDEAQYLRYSNYDYTALFASLNDSYENITLILTGSEIGVLEEFLGFNDRYSPLYKREHEIVHLDRFSRGESMQYLMKGFHETGMDVPDEEIRDAVEVLDGIVGWLREYGWLRYRGRSHGTAIDEVFQRAKSDIIDELSRYSRRYLTIMMAVSEGYNAWSSLKAYLERAEGKRINDGSLNTALRNLIKYGYLEKHGDEYRITDPVIERALRHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLW6</accession>
    <name>F0LLW6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polysacc_synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_02091</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468361.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02091"/>
    <dbReference type="EnsemblBacteria" id="ADT85065">
        <property type="protein sequence ID" value="ADT85065"/>
        <property type="gene ID" value="TERMP_02091"/>
    </dbReference>
    <dbReference type="GeneID" id="10042406"/>
    <dbReference type="KEGG" id="tba:TERMP_02091"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2088"/>
    <dbReference type="eggNOG" id="arCOG02209">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022017_5_1_2"/>
    <dbReference type="OMA" id="LFCTLVE"/>
    <dbReference type="OrthoDB" id="41033at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="342"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT85065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="509" mass="55789" checksum="F7ADF95E5BDC0566" modified="2011-05-03" version="1">MSEASQALHKIARGTGIIFAGTVISMFFGFLSRAIIAREFSKAEYGVFNLALTVLSIGLVIATLGFQNALPREVAFYREKEPGKVGRLISTAIAITAVSAVTTALLIFFLAGDISLIFREERLVSALRVIVLALPFSALTAVIISASRGFGRVREQVYFQNMVYSTVFLVLVAAGVAMGLPFGYVFFAYVAAQAVTLTALGADVRKSRLFTLRASFDLRIGRELVVFSLPLLFSGILAFIMNWTDTLMLGYYKGSEVVGLYNSAAPIARLIPIFLNSAGFLYAPIAAGLYAQGKVEEMGRTYQILTKWVFMLTLPIFSVMFLFPEATIGFFFGSKYVPAASALQILALGFMFHTFLGLNGLSLVVIGESKFIMLFNLISAMFNLLLNTLLIPVYGFEGAAVATVISYSTGNILVSSRLYQKTKIHPFSWNYVKPLAISFILLGIIKGLNLKVPSIWYAVPILVAFLGVYTLLVLLSRSIDKEDVELLLAVEKRLGVDLGIIKRVLRRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLX1</accession>
    <name>F0LLX1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468366.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02096"/>
    <dbReference type="EnsemblBacteria" id="ADT85070">
        <property type="protein sequence ID" value="ADT85070"/>
        <property type="gene ID" value="TERMP_02096"/>
    </dbReference>
    <dbReference type="GeneID" id="10042411"/>
    <dbReference type="KEGG" id="tba:TERMP_02096"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2093"/>
    <dbReference type="eggNOG" id="arCOG01403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_2_2"/>
    <dbReference type="OMA" id="VHAIDFF"/>
    <dbReference type="OrthoDB" id="83551at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="210"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="400" mass="45897" checksum="66C2B31F742CD220" modified="2011-05-03" version="1">MKILQICDHFKPAIDGVANYVYNLSNYLSKRHQITVLTSDVIEFQGIFRARKINIDHEKYNPNVEITRIPAKPPYFPYARGYYMLSYIAGVLKEMVGNVDVVHTHSYMLVHTDFVTFLVKVLSKHKKPLILTVHGYGRRSNRWLNLLSEFYNKSIGKWVLSKIDKIIVLDPRAKRYFIKIGVSPEKIVVIPNGIDYESLQSFKENVEKYKTHKGNVKTILYVGRLQKEKGVKELILAFNELLKKEKFNLNLLIVGDGPQRQELENLVRKLGIEDKVMFTGYLTGKPLLQAYYSADVFILPSKFEGVPTAILEAMATGLPIIATKVGGIPWIVKEERNGYLVDTSQVPSNLINTIIILISNQKQILKISTINKKDSQKYDWKNIAKNVEKTYIKVMFGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLY5</accession>
    <name>F0LLY5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468380.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02110"/>
    <dbReference type="EnsemblBacteria" id="ADT85084">
        <property type="protein sequence ID" value="ADT85084"/>
        <property type="gene ID" value="TERMP_02110"/>
    </dbReference>
    <dbReference type="GeneID" id="10042425"/>
    <dbReference type="KEGG" id="tba:TERMP_02110"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2107"/>
    <dbReference type="eggNOG" id="arCOG09616">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203612_0_0_2"/>
    <dbReference type="OMA" id="RNEWNRT"/>
    <dbReference type="OrthoDB" id="124124at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="63" mass="7766" checksum="FFFA484636E63E9B" modified="2011-05-03" version="1">MEEIEYIYGKNGKIKAVIVPIDLWEKIKAKFFDPSEFRGIYKDLKVDFERELRELREEWERDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLY7</accession>
    <name>F0LLY7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468382.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02112"/>
    <dbReference type="EnsemblBacteria" id="ADT85086">
        <property type="protein sequence ID" value="ADT85086"/>
        <property type="gene ID" value="TERMP_02112"/>
    </dbReference>
    <dbReference type="GeneID" id="10042427"/>
    <dbReference type="KEGG" id="tba:TERMP_02112"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2109"/>
    <dbReference type="eggNOG" id="arCOG02742">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052301_0_0_2"/>
    <dbReference type="OMA" id="VYPSNES"/>
    <dbReference type="OrthoDB" id="48221at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="181"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="428" mass="49620" checksum="16784648B03A5626" modified="2011-05-03" version="1">MKREDVLWTLAGISFLHGYLAGNVFSAIFGVGVSGYIVYSQRRFNPKIEVSKVFEERLEEGKRSKVVLKIKNLGSAVKIKVKEEAPREIKVEAPSEVVLMPGEEKFVEYFITPENKGEYELLTKIYVYDTSELYFDEIILGKYKIEVFPSVDSIREAAKEDYSIRLGEVYKKSILLGLESMELYGLREYLPGDDLRRIDWKASSRLGKLIVREFLKERESDVYIVLDATREMRKGVKRAKIDYASTLALHLATLLLKKNYSVGMIIYWDEGFKAIKPAKGRDQLDKIRNAIRFKPERGLLSFKSSISLKLSERGRRFLGKLFPKKRRSVAEALLNIKTPSYLILITDLMSNTSQLYRLMLMIRKKHKGIILSPNPILFYSGELDEETLKFLYEKYLEREKTVRKFNSVIPTIDLGPSDYLREIVRELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM02</accession>
    <name>F0LM02_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468397.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02127"/>
    <dbReference type="EnsemblBacteria" id="ADT85101">
        <property type="protein sequence ID" value="ADT85101"/>
        <property type="gene ID" value="TERMP_02127"/>
    </dbReference>
    <dbReference type="GeneID" id="10042442"/>
    <dbReference type="KEGG" id="tba:TERMP_02127"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2124"/>
    <dbReference type="eggNOG" id="arCOG09757">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100867_0_0_2"/>
    <dbReference type="OMA" id="FIIESHE"/>
    <dbReference type="OrthoDB" id="115621at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="242" mass="27729" checksum="D0C206C1286090C5" modified="2011-05-03" version="1">MKEKYYLIALIIVLSLSIVVLINIQNPSEGFSKVYFENLTVPEYIIPNKTYTMMFVIESHELYPVNYSFEVYVNDELIKQGKVAVNPGQRNEIPFEFSISKVSYEKVVLTHEQNIYFVNGLSLIVGNILRFQNLMSNMSADELLYLINHTPVMYDGSNNLTFILDVSRNISITQTRIIKNSAKIKEVYQFNMSKVGDESYKVVTSFLKTKYIPEPVIMKVVVKSSTGKVYQLSATIEVKGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM26</accession>
    <name>F0LM26_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Single-stranded-DNA-specific RecJ-like exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467171.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00897"/>
    <dbReference type="EnsemblBacteria" id="ADT83873">
        <property type="protein sequence ID" value="ADT83873"/>
        <property type="gene ID" value="TERMP_00897"/>
    </dbReference>
    <dbReference type="GeneID" id="10041214"/>
    <dbReference type="KEGG" id="tba:TERMP_00897"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.898"/>
    <dbReference type="eggNOG" id="arCOG00427">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042622_0_0_2"/>
    <dbReference type="OMA" id="AVGDMQE"/>
    <dbReference type="OrthoDB" id="45290at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="27"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="327"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="472" mass="52406" checksum="8E632FAC501FFA8D" modified="2011-05-03" version="1">MDKSGFLEKVREGAELIKMHIELGHTIRIISHRDADGITAGAILAKAIAREGGNFHLSIVKQLSEDLITELANEKQKIYVFSDLGSGSIKLIEKHLSDASVVIADHHPPEDGEIKNDNHILVNPTQFGADSVRDLSGSGVAYFVAREINEKNRDLSYLALVGAVGDMQEIDGQFHGMNLDIIEDAKELDLIEIRKEIRLYGRETRKLYQMLAYATNPEIPEITGDERKAIEFLRAKGFDPDMYYWQLREEEKKRFNDLIVIHLIKHGAGKEVIDRIIGDVVLIKVYKEGDPRHEAREFATLLNATGRLNAGTLGVAICLGDDDAFKAALKLVDEYKKEQIEARKYLIQNWNSSVIEKENVYVFYAGKNIKDTLVGIAANIAISSRLASPEKPVIILADSEEDESLVKGSARTTERALAKGYHLGEALRKVAEIIGGEGGGHAIAAGIRFPKDKLEEFAELINKALEEQTNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM36</accession>
    <name>F0LM36_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467181.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00907"/>
    <dbReference type="EnsemblBacteria" id="ADT83883">
        <property type="protein sequence ID" value="ADT83883"/>
        <property type="gene ID" value="TERMP_00907"/>
    </dbReference>
    <dbReference type="GeneID" id="26136352"/>
    <dbReference type="KEGG" id="tba:TERMP_00907"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.908"/>
    <dbReference type="eggNOG" id="arCOG13131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1352164_0_0_2"/>
    <dbReference type="OMA" id="LYSPLDM"/>
    <dbReference type="OrthoDB" id="88512at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="202" mass="23316" checksum="58B1FFF5D6BA7070" modified="2011-05-03" version="1">MELSPSVLVLLFLEDFARETNSIRKGVKYFEWQKRYNAYDVAYSIVGATLAKLIKDGYIQLELRKGLLGRKVLLTRIKSIPKKYGVVVEGINSMQAYKAVPLRSALFLSFPVSRFPAAFLGTYILRKELKDQDELKLREDPEVIKKKEELKAIFESFKMQNEELWKGIIKEVDKACDLVKGKEGITLYTPLDMLREKNESKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM60</accession>
    <name>F0LM60_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467205.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00931"/>
    <dbReference type="EnsemblBacteria" id="ADT83907">
        <property type="protein sequence ID" value="ADT83907"/>
        <property type="gene ID" value="TERMP_00931"/>
    </dbReference>
    <dbReference type="GeneID" id="10041248"/>
    <dbReference type="KEGG" id="tba:TERMP_00931"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.932"/>
    <dbReference type="eggNOG" id="arCOG05725">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1140609_0_0_2"/>
    <dbReference type="OMA" id="EHQMKFR"/>
    <dbReference type="OrthoDB" id="84883at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="252" mass="29616" checksum="47E49DC812573379" modified="2011-05-03" version="1">MDVEKLKELILKAEDIHKNFEKLFLRLYEYAGQNHPERVEEIILKLHELSEEKFEIASQIYRKTASIGGEIERVGKELQKNEHQMKFRLEEIMSLIGHAKESFSEKLKTKASLQRLFQFHRIYDYSVTQSLQRLSAEIEGLVLISEKEKKPPTSIIERLKKIEELEERLTTLTNLVFHLYSHPSWVYKIEESLKEWHSKGLLWVESRNVEQNTGIDREHVAQILDGLTLIGVVEKRKRGGESVYKLRGFGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMA9</accession>
    <name>F0LMA9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Archaeal Rqc2 homolog aRqcH</fullName>
            <shortName evidence="1">aRqcH</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rqcH</name>
        <name evidence="3" type="ordered locus">TERMP_02158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468428.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02158"/>
    <dbReference type="EnsemblBacteria" id="ADT85132">
        <property type="protein sequence ID" value="ADT85132"/>
        <property type="gene ID" value="TERMP_02158"/>
    </dbReference>
    <dbReference type="GeneID" id="10042473"/>
    <dbReference type="KEGG" id="tba:TERMP_02158"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2154"/>
    <dbReference type="eggNOG" id="arCOG01695">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003612_2_1_2"/>
    <dbReference type="OMA" id="MVYGKRN"/>
    <dbReference type="OrthoDB" id="69351at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00844_A">
        <property type="entry name" value="RqcH_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043681">
        <property type="entry name" value="RqcH_archaeal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="2">
        <location>
            <begin position="452"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="398"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="650" mass="75488" checksum="5B17EE9E7F91A01E" modified="2011-05-03" version="1">MKEEMSSVDIKYIVEELKSLKGARIDKIYHDGSEIRIKLHKAGEGRKDLIIEAGKRIHLTSYIREAPKMPSSFTMLLRKHLSGGFFDNIEQHDFDRIVKIRIGNYTLIAELFRKGNIILVDENNIIIGALRYEEFKDRAIKPKHEYKLPPARESPIEVSWERFLELIKSENVEIVRALARKLNMGGLYAEEILLRAEIDKKKKANELSEDDLRLIFEKMKEVFNAPKKPNIIYKDGTMIDVVPIELKWYENYEKKYFETFSEALDEYFGKITVEKAKIERTKRLEEKKRQILATLRRQEEQMKGFEAEMKKNQELGDLIYANFTFIDNLLREFSKAVEKLGWEEFKKRIEEGKKAGNKIALMVKSIDPKEKAVTIEIEGRKIKLYLNKSIGENAEIYYEKAKKAKHKLEGAKRAYEDTKKKLQEIEKLIEEEMKKELKVKKLEKRKKKWFEKFRWFISSEGFLVIGGKDATTNEMVVKRHMGDNDLYCHADVHGAPHVVIKDGQKAGEKTIFEACQFAVSMSKAWSEGVYSADAYWAYPNQVTKKAPSGEYLGKGAFMVYGKRNWYHGIPLKLAVGIINYEGEDLVMCGPVDALKAHTKRYIVIRPGDLKKSELVKKIKKIFERWGYKVAEEDIMAILPPGEGEIVEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMB5</accession>
    <name>F0LMB5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_02164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468434.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02164"/>
    <dbReference type="EnsemblBacteria" id="ADT85138">
        <property type="protein sequence ID" value="ADT85138"/>
        <property type="gene ID" value="TERMP_02164"/>
    </dbReference>
    <dbReference type="GeneID" id="10042479"/>
    <dbReference type="KEGG" id="tba:TERMP_02164"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2159"/>
    <dbReference type="eggNOG" id="arCOG04466">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006855_3_3_2"/>
    <dbReference type="OMA" id="NLWGFAY"/>
    <dbReference type="OrthoDB" id="11037at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="PTHR11616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT85138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="528" mass="58733" checksum="E809DCBB621C56EB" modified="2011-05-03" version="1">MEQRDRWATKLGLILAMAGNAIGLGNFWRFPYQLASNGGGAFMIPYFIALFFLGIPVMWIEWTTGRYGGKYGHGTLGPMFYLMARESVKPKTALIFGVIGGMLAFSVSSLLSSYYYQVIGWSAAYTYYSLTGAYFGQDTVKFFLNYVANLKAVIFFWGITMVLLGIAVGQGVSKGIERWVKVMMPLLYVFAILLVIRALTLGSPVKPEWSSIKGLEYIWTPNFTALKQNFFKISLAAAGQIFFTLSLGMGIIHNYASYLGPEDDVALSGLATVSLNEFAEVILGGSLAIPIAFAYLGPEQAIKGGVGLAYMALPNVFMHMPGGRIFGAMWFLLLWFAGFTSAIATYNYLVAMLEEDLKIDRKVGTWVVFVFLFLLGLPVALDSSLVYLSELDMWVGSYFLVLLGFFDVIVGVWLFKPDNFWEELHKGAFINVPEWFKPIIMYIAPLFMAVLLIGNTKDYYSMGALRFHVSKAYVENVLGGSYPDAVPLVLRARIVILIILIIGAIEAYLAIKKKYGEELEKNEVIIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMD0</accession>
    <name>F0LMD0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_02179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468449.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02179"/>
    <dbReference type="EnsemblBacteria" id="ADT85153">
        <property type="protein sequence ID" value="ADT85153"/>
        <property type="gene ID" value="TERMP_02179"/>
    </dbReference>
    <dbReference type="GeneID" id="10042494"/>
    <dbReference type="KEGG" id="tba:TERMP_02179"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2174"/>
    <dbReference type="eggNOG" id="arCOG00704">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02079">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03610">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001115_0_0_2"/>
    <dbReference type="OMA" id="VAFMIGN"/>
    <dbReference type="OrthoDB" id="27at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007280">
        <property type="entry name" value="Peptidase_C_arc/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04151">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="249"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="PPC" evidence="6">
        <location>
            <begin position="1437"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="7">
        <location>
            <begin position="1600"/>
            <end position="1679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT85153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1895" mass="209589" checksum="F1842D7924EB203B" modified="2011-05-03" version="1">MNKRTVSLLIVLLMILSAIPVALPVTLVSAENTPQVTHTITKVNAVAKEPEKTAPPITKIEPELLKILEGKVTVNVPEVNGEKLLPIHIVALSSIDSKLKGIQIVGKREIAGMVVYLALVPIKEEYKKVLLKIASLPEVEAVTRTNPFEPVGTFEEPDAKNSITTKTIQIRIPEIRRKIDLSKLEKFSVKKLKLPEIMKLREKSPLRRGELKITERESLNIENPIKPADYFAIYHHGSWNTWLNLGITGAGVNVAVIDSGVDFGNPDLQDAYAVETNPSSPYYGWPIAFSGHSMIWYLLFNYTFPTYIYSWYADTSIELPYFLVYGNVSIGYKGNFTTVFTSMSLANIENDAERAAFINETLAWMGVTNSSKILLVDDDGGWTLDEFYTAALDILGLNYTVYEVPYGSSGPNATVLSQYDAVIWFTGDTYQYTLTQNDTANLMAYLNNGGKLWLISQDLLEELPLNDTFVTDYLHVAGVDPDYPVPTIIKMANNTYKAKSIYYGFYGSLTDAFADFVFPDNESQVLAVGYEAIVGIQWIDPDTGNVTQITYMKFPMNETLGVPTKSGIFHFGFHPDIALWVDWNGGYIIVADPENATKYDTVYADITPMLVDAGSITLEYLDFNEDSGHTKDNPVIQVDFWDTFNDRFGQDGYADLSGGLIYFIADGVNPIPYEDVVSSNWGLPMPIPENGDLVAFMIGNVYVAGGDHGTLCAAAVGARGRTFYGLTFGNAIGAKIIAEGSLYQGGSWIDYVFFAVEGYDGIPGTGDEALVVSNSYGASSVIAKGYTWDDRFLYWITHFYAPQVSFFFAAGNGGPGYGTVTSEGASPGVITVGAAVEFGYRALFGYDDGPWGYELANYGDVVWFSNRGPNALGQVDPDVLAVGAYALGSLPLNEVGDGFWASDLWAGTSLATPMAAGIAALVYEAYYSAHGTWPTAEEVKEILMSTTKNVNHDVFSQGAGFLDAYRAVQAALNLDGIIVSPSMWQAGETEYPAFANVIYPGDSASHVFEVRNMNVSASKDVEVSAEVFQKIGEVEFNVTGNSWYMYRIDPFIPNGTDLMKITLYFDYDYFDTERDYSADAFPWFRVWDVTYVYDPESNTTVPTFNLLTQSLNEGTSISATLGNPLQKFHDGLYVQIRDVLRYYGKTDTYPAKLKLEFYKRVPWDWVAINTTTLTVPANGTATFMATVTVPLNASYGVYEGAIYLKYDRYETTIPVSVVVASPTPNFEFGGNTNASGLYDNSNVYGQFDWSWRYESGDWRLFYFNVSNAHNMTNAYLIADVSWDGIPTDINLHLLGPAEDGSLLPFSAIWPGIFGPYTLAEIGRSIDGYVGAGMFKLFTTSGTSREVIAAPASPGLHALWLHNVLFDGKQSYRTFSGKIGMASVTPGTWMESINSTEGKKSFIVHLPSSFGMLKATAAGLTAPIIYKDKLAPPTGSADYYTVTVKDATKLSITLTSLWDDLAGVDLDLYVYYNGQLVGASYTSTADEGVIIQLPASGTYTIEVYSWNNPTTNATYDLKILAIEQGDLQVESIKEIADGVYNVTVSYTMSSDKFENANTFYGTIYFGYDAAPMLIEVPVTLYKTTPEIIEEFGTVVIMQPYDLSLNLVPNEEIAEIGTTYTLTTFVSNYGPYDATEAVVNLYKDGELIDQVKLPEFAKGEVYKVEFNVPIDDAELHEYMVVLESPYDEESNVVYVKGVDKVEFSTYNTGNATVTSSFGGYAEITSTDVTNRKITITVDGDHGAVATLLINLPKDLHYYSVHVTDADLLSKELLTTPNSHILKVRIKLHSPATVNVDYMTTGEALQEMNFVWYMLYQRYSMKFNELYNKSIELGIDNETLQEALHYKELAEESYKEAWKFGNPLQGYIRSLPYMRKAYLNIKRAVEILSKAIEEAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMJ0</accession>
    <name>F0LMJ0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alanyl-tRNA synthetase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467267.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83969">
        <property type="protein sequence ID" value="ADT83969"/>
        <property type="gene ID" value="TERMP_00993"/>
    </dbReference>
    <dbReference type="GeneID" id="10041310"/>
    <dbReference type="KEGG" id="tba:TERMP_00993"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.996"/>
    <dbReference type="eggNOG" id="arCOG01256">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1656933_0_0_2"/>
    <dbReference type="OMA" id="AKWTASV"/>
    <dbReference type="OrthoDB" id="84200at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="151" mass="17533" checksum="A503D612CFA98565" modified="2011-05-03" version="1">MNELEVRTHTALHVVKGAVVKVLGEKAKWTASVYVNGNHGRLTVKFDRKPTQEEIAKIERMANEKVKENVPIHVYELPREEAEKRFGEDMYDLFPIPPEIKTLKVVVIENWNVNACNKQHTKTTREVGKIKIKKVRFRKSKELLEISFDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMJ2</accession>
    <name>F0LMJ2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_00995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467269.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00995"/>
    <dbReference type="EnsemblBacteria" id="ADT83971">
        <property type="protein sequence ID" value="ADT83971"/>
        <property type="gene ID" value="TERMP_00995"/>
    </dbReference>
    <dbReference type="GeneID" id="10041312"/>
    <dbReference type="KEGG" id="tba:TERMP_00995"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.998"/>
    <dbReference type="eggNOG" id="arCOG01434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_0_0_2"/>
    <dbReference type="OMA" id="RCECGEP"/>
    <dbReference type="OrthoDB" id="16594at2157"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="8">
        <location>
            <begin position="58"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="385" mass="42943" checksum="A33DAEA16D48D818" modified="2011-05-03" version="1">MLRCTACGREYSLRKPYQRCECGEPLELKLFEGFAGIGKSVWERFVQFFPFELDLDLSLGEGDTPLIRARKLSKELGIQLYLKNETVNPTWSFKDRGTFLGIHRALQLGFDKVGTVSTGNMAASVAAYASRAGLKAYILVSSYIAEEKLKQIAVYGAEVIKVRGDYGKLYYESLNLGQKLGIYFINSDDPFRIEGYKGISFEIVEEVMPDYVVVPTSSGGLIRGIIKGFLELKKSKLIDKLPMFVCVQAEGCSPIYKAFIEGKEKIERFENQHTIAHAIENPYPPSGNAVLRLLRKLNGMCVAVSDEEILKAQRMLAQEGVFVQPASATGIAAVKKLREEGRIKGDERVVSILTGAGLKTLHQLGRFEVRECEMKRLKDCLVGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMJ9</accession>
    <name>F0LMJ9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Adenylosuccinate lyase</fullName>
            <shortName evidence="9">ASL</shortName>
            <ecNumber evidence="5 9">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_01002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="5 9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467276.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01002"/>
    <dbReference type="EnsemblBacteria" id="ADT83978">
        <property type="protein sequence ID" value="ADT83978"/>
        <property type="gene ID" value="TERMP_01002"/>
    </dbReference>
    <dbReference type="GeneID" id="10041319"/>
    <dbReference type="KEGG" id="tba:TERMP_01002"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1005"/>
    <dbReference type="eggNOG" id="arCOG01747">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_0_1_2"/>
    <dbReference type="OMA" id="ASSCEKI"/>
    <dbReference type="OrthoDB" id="39322at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="10">
        <location>
            <begin position="360"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="453" mass="51633" checksum="A2905F63E3B5740E" modified="2011-05-03" version="1">MAVHPIDYRYGSEEMRKIWEEENKLQKLLDVEAALARAHAKVGNIPKKSAEVISEKANTKYVKLERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKDSLGIVLKDLRELRTILKELAKKHKHTACIGRTHGQHAVPTTYGMKFAIWLDEIQRHIERIEQAKERILVGQMSGAVGTMASFGEKGLQVQRLVMEDLGLKPARISNQIIQRDIYAELVMILALIASTLDKIALEVRNLQRTEILEVSEPFGKKQVGSSTMPHKRNPIRSEKICGLARIIYSNVIPALLNNPLWHERDLTNSSVERVILPETFMLLDEMLKNMKKVLSGLEFFPENIKRNLYLTNNLIMAEPLMLKLTEKGMGRQEAHEVVRQIAMKAFYEKRDLIEIAKENEVVREYLDDEDFKGLKPENYIGLAPQIVDGVIRYIEEIEQKEAQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMK3</accession>
    <name>F0LMK3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MinD-like P-loop ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467280.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01006"/>
    <dbReference type="EnsemblBacteria" id="ADT83982">
        <property type="protein sequence ID" value="ADT83982"/>
        <property type="gene ID" value="TERMP_01006"/>
    </dbReference>
    <dbReference type="GeneID" id="10041323"/>
    <dbReference type="KEGG" id="tba:TERMP_01006"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1009"/>
    <dbReference type="eggNOG" id="arCOG04073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067767_1_0_2"/>
    <dbReference type="OMA" id="GIGCVVI"/>
    <dbReference type="OrthoDB" id="50469at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="295" mass="32279" checksum="9AA2044E27064CDF" modified="2011-05-03" version="1">MQIVIASGKGGVGKSTVAASLIYLLKDRYKLIAVDADADAPNLHLLFGVKKWEEEKELTGAKVARIDQDTCIRCGICYERCPYESIKLVDGKYVVNELTCEGCGVCKLVCPVRGTITLEEVRSGVIRKTTTGYGFPLISAQLDVGRPNSGKLVTEEKEWAKKIMYEQELDHMIVDSAAGIGCQVIASVGGADVAILVAEPTPASLSDVKRVYKVVQHFREPAYLIINKADINPGFEGLYEFAEQEGIPILGEIPYDRAIPYSMTMLKPFVEAFPESKASKALKEIAKAVEDEILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMP0</accession>
    <name>F0LMP0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0179 protein TERMP_01043</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0179 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467317.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01043"/>
    <dbReference type="EnsemblBacteria" id="ADT84019">
        <property type="protein sequence ID" value="ADT84019"/>
        <property type="gene ID" value="TERMP_01043"/>
    </dbReference>
    <dbReference type="GeneID" id="26136494"/>
    <dbReference type="KEGG" id="tba:TERMP_01043"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1046"/>
    <dbReference type="eggNOG" id="arCOG04477">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121764_0_0_2"/>
    <dbReference type="OMA" id="CPSHEYC"/>
    <dbReference type="OrthoDB" id="108341at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00498">
        <property type="entry name" value="UPF0179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005369">
        <property type="entry name" value="UPF0179"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40699">
        <property type="entry name" value="PTHR40699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03684">
        <property type="entry name" value="UPF0179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006595">
        <property type="entry name" value="UCP006595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="142" mass="15972" checksum="F819E578E9B044A4" modified="2011-05-03" version="1">MVITLVGEKLAKPGVEFIYYGPADPCKTCRLARVCVGNLEPGRRYKVVRVRNIEHSCPLHEGKVRVVEVVEPSIEVAIEPRLAIVGSKIRINFVECDDPEKKDVIRPEGLFEGDAVKILEIVGEIECNGKKYKVVKVMREKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMQ1</accession>
    <name>F0LMQ1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partition smc-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01054"/>
    <dbReference type="EnsemblBacteria" id="ADT84030">
        <property type="protein sequence ID" value="ADT84030"/>
        <property type="gene ID" value="TERMP_01054"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01054"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1057"/>
    <dbReference type="eggNOG" id="arCOG00368">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_6_4_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="100" mass="11315" checksum="D911BFD881B3B70C" modified="2011-05-03" version="1">MTALAFVFAIQRYKPAPFYLFDEIDAHLDDANVKRVADLIKEASQHSQFIVITLRDVMMANAEKIIGVSMRDGISRVVSLSLEKAMEYLEKARQRNALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMR0</accession>
    <name>F0LMR0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467337.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01063"/>
    <dbReference type="EnsemblBacteria" id="ADT84039">
        <property type="protein sequence ID" value="ADT84039"/>
        <property type="gene ID" value="TERMP_01063"/>
    </dbReference>
    <dbReference type="GeneID" id="10041380"/>
    <dbReference type="KEGG" id="tba:TERMP_01063"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1066"/>
    <dbReference type="eggNOG" id="arCOG04116">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023387_0_0_2"/>
    <dbReference type="OMA" id="FADMRMA"/>
    <dbReference type="OrthoDB" id="19750at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="3">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="257"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="480"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="602" mass="68120" checksum="94A8C07999E9C7A0" modified="2011-05-03" version="1">MKVFVADTSVIVDGRLTQYLETLGEKVKVVIPEAVVAEIEHQANEGKAIGHVGLEELKKLRKMADGDKILLEFYGERPELWQIRRAKAGEIDHMVREVARELNAVLITGDQVQRDIAIAKGIEVVYLTGRKEVKHRLEDFFDEHTMSVHLKAGVKPLAKKGKPGEWHLVPIRDEPLTDEELEEIADDIVERAKRDPESFIELDEPGATVVQLRNYRIVIAKPPFADRIEITAVRPITKLSIEDYELSEKLLERLTDKAEGILIAGAPGEGKTTFAQALAEYYASMGKIVKTMEKPRDLQVSEEITQYTALGGRMEKTGDVLLLVRPDYTIFDEMRKTSDFKIYADLRLAGVGMIGVVHATKPIDAIQRFIGRVELGMIPQIVDTVIFIKAGRVDKVLTLEYKVKVPTGMTEEDLARPVIEVRDFDTGELEYEIYTYGEEISVVPVKKKEKPPAMKLAEKRLKQEIKKFLPDVYTEVELVSPHKAVIYADEFDIPAIIGKKGKRITEIEKRLGISIDVRSFDEKMKEMPKERIPVEVEEKKKQIVLRVSPDYAKRPLKFFGGEQYVFTATPSKKGIVKVSKNTPIGRELKRLLEAGIEIWASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMW1</accession>
    <name>F0LMW1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdopterin biosynthesis MoeA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467388.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01114"/>
    <dbReference type="EnsemblBacteria" id="ADT84090">
        <property type="protein sequence ID" value="ADT84090"/>
        <property type="gene ID" value="TERMP_01114"/>
    </dbReference>
    <dbReference type="GeneID" id="10041431"/>
    <dbReference type="KEGG" id="tba:TERMP_01114"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1117"/>
    <dbReference type="eggNOG" id="arCOG00217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_7_2_2"/>
    <dbReference type="OMA" id="GKPLMHG"/>
    <dbReference type="OrthoDB" id="51611at2157"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="184"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="400" mass="43462" checksum="554B85904E8525FE" modified="2011-05-03" version="1">MAFLKVVPLEEALKVINSFSLKPKIEEIKLEEALGRVLAEDIESPMDVPPFDRSTVDGYAVKSKDTWGAGETNPVKLKVVGEINAGDMPKIELKDGESAYISTGAPLPKGADAVIPFEEVDRENEWVVIYKPVYPDYGVMKAGADVPKGKLLLKKGTKLSFKETALLSAVGFEKVKVFAKPKVAVISTGNEIILPGKDLKYGQIYDINGRAISDAIRELGGEAYFLGIARDDRESLKEKILEGLKYDMIILSGGASGGIRDLTASIIEELGEIKVHGIAIQPGKPTIIGLIEGKPIFGLPGYPTSCLTNFTLLVAPLIKKLLGQSQEYRKVKKKLAHKVFSVKGRRQFLPVRIEDDKAVPILKGSGAVTSFIDADGFIEVPENVEILDEGEEVEVILFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMW4</accession>
    <name>F0LMW4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467391.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01117"/>
    <dbReference type="EnsemblBacteria" id="ADT84093">
        <property type="protein sequence ID" value="ADT84093"/>
        <property type="gene ID" value="TERMP_01117"/>
    </dbReference>
    <dbReference type="GeneID" id="10041434"/>
    <dbReference type="KEGG" id="tba:TERMP_01117"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1120"/>
    <dbReference type="eggNOG" id="arCOG05761">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535999_0_0_2"/>
    <dbReference type="OMA" id="DYSEYWK"/>
    <dbReference type="OrthoDB" id="14112at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="504" mass="58821" checksum="3331EF165E2F9961" modified="2011-05-03" version="1">MEDYVFKLLRFAGRREKLTPAKRVRDFQSKIQNSKNGEPVEVQGFLLLRQPPYAPKDALYYILSPLSPSELKKAGLRAYLILRITENSKVNARFRSGEYVKVSGIIDSYPYGNLRMIHVESLESANYSDYWLEYEEMALSKKEFEDLFMKTIYANYDLEKAVIYSLFASPIIVGTKKNWGEGVTFSVFKNEQKIILSVWETVRYLYSLFPMELHLRKDNKDSFVDPELDLDFVLFNPNNTNLKYYVPYNKKILSKEIPAPNWAVEYFENKNAVFLTPKRYSLLSPDDPLAYSSETPFILSEPIGYERNKELEELIPNVIITIFKEREKIASLSAGDEIMQKFRDRFERWIMKNRHEYGEKFDALMIKGMIFETNTRYLLSAHILGSIGRFKGKIDTGIIHDVLLINQEILDLWMNELPEKVILSAVETYERYISGDKRANTALNIFMDLEATSLDGTVSREEFYTALLEYGFKEAYAKEIIERLIAEGHLYEPFFGKLKMIKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMW6</accession>
    <name>F0LMW6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">30S ribosomal protein S28e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps28e</name>
        <name evidence="4" type="ordered locus">TERMP_01119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467393.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01119"/>
    <dbReference type="EnsemblBacteria" id="ADT84095">
        <property type="protein sequence ID" value="ADT84095"/>
        <property type="gene ID" value="TERMP_01119"/>
    </dbReference>
    <dbReference type="GeneID" id="26136573"/>
    <dbReference type="KEGG" id="tba:TERMP_01119"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1122"/>
    <dbReference type="eggNOG" id="arCOG04314">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178987_2_1_2"/>
    <dbReference type="OMA" id="MHGEASQ"/>
    <dbReference type="OrthoDB" id="121548at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_S28e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_S28e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="PTHR10769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="69" mass="7659" checksum="85903DB59165AE7F" modified="2011-05-03" version="1">MSDEGYAAEVIEIVGRTGVTGGVTQVKVRVLEGRDKGRVIRRNIKGPVRVGDIVILRETEREAREIKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMY7</accession>
    <name>F0LMY7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+) H(+) antiporter subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467414.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01140"/>
    <dbReference type="EnsemblBacteria" id="ADT84116">
        <property type="protein sequence ID" value="ADT84116"/>
        <property type="gene ID" value="TERMP_01140"/>
    </dbReference>
    <dbReference type="GeneID" id="10041457"/>
    <dbReference type="KEGG" id="tba:TERMP_01140"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1143"/>
    <dbReference type="eggNOG" id="arCOG03099">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086615_2_2_2"/>
    <dbReference type="OMA" id="YLYVNWI"/>
    <dbReference type="OrthoDB" id="98474at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34584">
        <property type="entry name" value="PTHR34584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019239">
        <property type="entry name" value="MrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="161" mass="18014" checksum="9F8B032A5906F952" modified="2011-05-03" version="1">MRGIIPTALLAFITYIIFTGSAKPFDLATGVVVAIGVGLLVGKYLVQSDAKALNPVRWLWLGIYFIWYMLVAEVKAHLDVMIRTITGSYTPGIVKVPIDVKTDYAKTLVANSITNTPGTVVVDLDDEYMYVNWINVTTEEPEKAKKEICEDFEKYAKKIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN07</accession>
    <name>F0LN07_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-specific phosphofructokinase</fullName>
            <ecNumber evidence="3">2.7.1.146</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ADP-dependent phosphofructokinase</fullName>
            <shortName evidence="3">ADP-Pfk</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pfkC</name>
        <name evidence="4" type="ordered locus">TERMP_01160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ADP + beta-D-fructose 6-phosphate = AMP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.146"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carbohydrate kinase PfkC family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.146" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467434.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01160"/>
    <dbReference type="EnsemblBacteria" id="ADT84136">
        <property type="protein sequence ID" value="ADT84136"/>
        <property type="gene ID" value="TERMP_01160"/>
    </dbReference>
    <dbReference type="GeneID" id="10041477"/>
    <dbReference type="KEGG" id="tba:TERMP_01160"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1163"/>
    <dbReference type="eggNOG" id="arCOG03370">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046643_0_0_2"/>
    <dbReference type="OMA" id="NRIFEFR"/>
    <dbReference type="OrthoDB" id="15153at2157"/>
    <dbReference type="UniPathway" id="UPA00109"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043844">
        <property type="term" value="F:ADP-specific phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008443">
        <property type="term" value="F:phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00561">
        <property type="entry name" value="ADP_PFKinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007666">
        <property type="entry name" value="ADP_PFK/GK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015990">
        <property type="entry name" value="ADP_PFK/GK_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011790">
        <property type="entry name" value="ADP_PFK_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208">
        <property type="entry name" value="PTHR21208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04587">
        <property type="entry name" value="ADP_PFK_GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015883">
        <property type="entry name" value="ADP-Pfk_glckin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02045">
        <property type="entry name" value="P_fruct_ADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51255">
        <property type="entry name" value="ADPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="460" mass="53128" checksum="A7420929D78D848F" modified="2011-05-03" version="1">MIDVFQDAQKLSLYLAYNVNVDAIVYLRKEHIEKLIRELGSENVRRRMEDYPREINEPIDFVARLIHALKTGKPMAVPLVNEEMHTWFDERFKYNVERIGGQVGIIANLLANLDFKKVIAYSPILAKRQAQMFVNKPNLLYPVVENGELVLKKPIEAYRENDPVKVNRIFEFRKGTRFKLGNEVIEVPHSGRFIVASRFESIRIETKEDLKPFLPKIGELVDGAILSGYQGIKKRYSDGKDANYYLRKAKEDIRLLKKNKDIKIHVEFASIQDRELRKKVIYNIFPLADSVGMDESEIAHILNSLGYPKLADRIFNYNRIEDTVLGGKIILDELNLEILQIHTIYYLMYITHKDNPLSEDELRQSLEIATTLAAARASLGDIKSPEDFKVGLRVPYNEYGEFVKLRFEEAKRKLRTREYKIVIIPTRLVKNPVSTVGLGDTISAGAFTSYLALLRRKGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN16</accession>
    <name>F0LN16_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zinc_ribbon_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467443.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01169"/>
    <dbReference type="EnsemblBacteria" id="ADT84145">
        <property type="protein sequence ID" value="ADT84145"/>
        <property type="gene ID" value="TERMP_01169"/>
    </dbReference>
    <dbReference type="GeneID" id="10041486"/>
    <dbReference type="KEGG" id="tba:TERMP_01169"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1172"/>
    <dbReference type="eggNOG" id="arCOG01917">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_978681_0_0_2"/>
    <dbReference type="OrthoDB" id="78924at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zinc_ribbon_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="284" mass="32753" checksum="1E73C7E8453BF574" modified="2011-05-03" version="1">MYCPKCGTQLDEEFDFCPVCGYDLRKVKEKIYSKKPMSNEFRVKFPETKCTVSVVGVSEDLRKYTGKGVEINLGSLTLEDTLKVFSQLPTEYPKKDIKDLKKGKKVPVTLTLDREEGTLFVYLNPDRTYMVQGGVRKLETAFDISYNASREEVQKIIRRFYTDKNIFNEWSEQIKGLKESRRVLFYASFLDDDGVYKDICVLNDGIAIGRVDNGELIGYEFFCPYELVKEIKFKKGWLSSGVEIRYRDPEKGKTRKVEVSIGNKDEYYGLKSTLEKVIPGKVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN40</accession>
    <name>F0LN40_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tyrS</name>
        <name evidence="9" type="ordered locus">TERMP_01193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467467.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01193"/>
    <dbReference type="EnsemblBacteria" id="ADT84169">
        <property type="protein sequence ID" value="ADT84169"/>
        <property type="gene ID" value="TERMP_01193"/>
    </dbReference>
    <dbReference type="GeneID" id="10041510"/>
    <dbReference type="KEGG" id="tba:TERMP_01193"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1196"/>
    <dbReference type="eggNOG" id="arCOG01886">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035267_1_1_2"/>
    <dbReference type="OMA" id="YIGFEIS"/>
    <dbReference type="OrthoDB" id="59062at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02009">
        <property type="entry name" value="Tyr_tRNA_synth_type4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023678">
        <property type="entry name" value="Tyr-tRNA-ligase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="251"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="375" mass="43258" checksum="C6F26A78B9C9E9EE" modified="2011-05-03" version="1">MDIEKKIELITRKPTEEVLTVKNLRQLLEMGVPLQHYIGFEISGYIHLGTGLMAGAKIADFQKAGIKTRIFLADWHSWINDKLGGDLETIQKVALTYFKEGMKQSIKVMGGDPDKVEFVLASEILEKGDYWQTVIDISKNVTLSRVMRSITIMGRQMGEAIDFAKLIYPMMQVADIFYQGVNIAHAGMDQRKAHVIAIEVAEKLKYHPLIWEGKKYKPVAVHHHLLLGLQEPPKWPIESEEEFKEIKAAMKMSKSKPYSAVFIHDSPEEIRQKLRKAFCPAREVRYNPVLDWAEHIIFREEPTEFTIHRPAKFGGDVTYTTFEELKKDFAEGKLHPLDLKNAVAEYLIELLKPVREYFEKHPEPLELMKEVKITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN53</accession>
    <name>F0LN53_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02219"/>
    <dbReference type="EnsemblBacteria" id="ADT85192">
        <property type="protein sequence ID" value="ADT85192"/>
        <property type="gene ID" value="TERMP_02219"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02219"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2213"/>
    <dbReference type="HOGENOM" id="CLU_3338673_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="37" mass="4437" checksum="C3C0A66E18401779" modified="2011-05-03" version="1">MNNETLMLRDILAERGLRSRNLEKFIRGLELFFVGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN61</accession>
    <name>F0LN61_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747422.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT85200">
        <property type="protein sequence ID" value="ADT85200"/>
        <property type="gene ID" value="TERMP_02227"/>
    </dbReference>
    <dbReference type="GeneID" id="10549051"/>
    <dbReference type="KEGG" id="tba:TERMP_02227"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2221"/>
    <dbReference type="HOGENOM" id="CLU_1393638_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="195" mass="22933" checksum="8D1F93DD8FCEA997" modified="2011-05-03" version="1">MKKVNSYSVKSSNIITNDIPPKINQNSLIDFRRKLTSLIVRDLFDVYLRNPYYKRPVLVFGPDILYVHFDKTFYVIEREIGKALNRWANLAQAFSLNELAPVKADRIVLNEFYTVPLYHETLRGILHEERTLTFLGNEPRKYTSSELREISRALLSSKGALFEFEMFSRIEKRNKETLVAKFYLFVPLEKGLEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN78</accession>
    <name>F0LN78_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747439.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02244"/>
    <dbReference type="EnsemblBacteria" id="ADT85217">
        <property type="protein sequence ID" value="ADT85217"/>
        <property type="gene ID" value="TERMP_02244"/>
    </dbReference>
    <dbReference type="GeneID" id="10549068"/>
    <dbReference type="KEGG" id="tba:TERMP_02244"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2238"/>
    <dbReference type="eggNOG" id="arCOG11753">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161131_0_0_2"/>
    <dbReference type="OMA" id="VADCWEC"/>
    <dbReference type="OrthoDB" id="135632at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="130" mass="14907" checksum="419E16133B18D9DB" modified="2011-05-03" version="1">MGAIGSFAEPRLIVGIKDLVNEKNERTRVYYTARGIKGRENGQLLFEALIEYLVADCWECVEKLASEEFDEIAQEHGFKVLAKEIEWDVPKARVLFGYVEIFKNDSLMKGLEEGFNWLKTDLDALFISLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGX5</accession>
    <name>F0LGX5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagella protein F-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467481.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01207"/>
    <dbReference type="EnsemblBacteria" id="ADT84183">
        <property type="protein sequence ID" value="ADT84183"/>
        <property type="gene ID" value="TERMP_01207"/>
    </dbReference>
    <dbReference type="GeneID" id="10041524"/>
    <dbReference type="KEGG" id="tba:TERMP_01207"/>
    <dbReference type="eggNOG" id="arCOG01824">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1575034_0_0_2"/>
    <dbReference type="OMA" id="HNGIYVS"/>
    <dbReference type="OrthoDB" id="106365at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42200">
        <property type="entry name" value="PTHR42200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="171" mass="19033" checksum="FC6E7F6ABAC2A9D0" modified="2011-05-03" version="1">MGFSVSASFALLLTVTLISFAIMYTAIDNTYSNVLDAIEDHANIVTITKSSQLYVSLYDYTTQLNVSVYDVIFNITNSGTTLSPPRWNFVYDGVLTSTNIDIENKQYIVPGDSLLLTVLNVPKTTDVHALVVVTETGCNLKFKWRWIWLNQTAGTGTVEVINSAWYCPREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGZ4</accession>
    <name>F0LGZ4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Archaetidylinositol phosphate synthase</fullName>
            <shortName evidence="1">AIP synthase</shortName>
            <ecNumber evidence="1">2.7.8.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol = CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:36823"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:74004"/>
            <dbReference type="ChEBI" id="CHEBI:74006"/>
            <dbReference type="EC" id="2.7.8.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.39" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01226"/>
    <dbReference type="EnsemblBacteria" id="ADT84202">
        <property type="protein sequence ID" value="ADT84202"/>
        <property type="gene ID" value="TERMP_01226"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01226"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1227"/>
    <dbReference type="eggNOG" id="arCOG00670">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080384_1_2_2"/>
    <dbReference type="OMA" id="DGNMARQ"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02242">
        <property type="entry name" value="AIP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044270">
        <property type="entry name" value="AIP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="174" mass="18863" checksum="6DA679985EC592B6" modified="2011-05-03" version="1">METIVRPLAKIGMTPNQLTVIGMLISLLAAYFFAMGEQRLAALTLIFGSLIDALDGTLARLTGKTSRFGAFLDSTTDRVSDGVVLFGIAYGGLVDWKIAFIALIGSYLVSYERCRAELAGSGTLAVGIAERAERLLILITAALFNRVDVGVYIVALLAWITAFQRLWEAKKRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH46</accession>
    <name>F0LH46_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetamidase/formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466306.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00030"/>
    <dbReference type="EnsemblBacteria" id="ADT83008">
        <property type="protein sequence ID" value="ADT83008"/>
        <property type="gene ID" value="TERMP_00030"/>
    </dbReference>
    <dbReference type="GeneID" id="10040349"/>
    <dbReference type="KEGG" id="tba:TERMP_00030"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.29"/>
    <dbReference type="eggNOG" id="arCOG01004">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032013_1_0_2"/>
    <dbReference type="OMA" id="GGNMDCR"/>
    <dbReference type="OrthoDB" id="104958at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="PTHR31891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="299" mass="32155" checksum="A1CA5C0E8E2E6207" modified="2011-05-03" version="1">MILIPKDKHVYSFGPSMKPAAKAKPGDIVVFETIDALGGQIQSEKDTIAQIDFSRVNPATGPLYVEGAERNKVLAVKILDIKVEEKGVIVTAPNAGVLGNIVKAPKTRICRIKHGIVHFGNIKIPAKPMIGVIGVAYDEEVPTGTPGKHGGNMDTNLIAKGTTLYLPIFRKGALLAIGDLHAVMADGEVCVSACEVSGSVKVEVDVLDGKLEWPLLETADAYYLLVSKEDINDAIQEGVKLGVEALAKANKLEWDEAYMLASLVMDVQISQIVDPAKTIRVRIPKEYVGLEAFLNTEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHA1</accession>
    <name>F0LHA1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_00085</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466361.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00085"/>
    <dbReference type="EnsemblBacteria" id="ADT83063">
        <property type="protein sequence ID" value="ADT83063"/>
        <property type="gene ID" value="TERMP_00085"/>
    </dbReference>
    <dbReference type="GeneID" id="10040404"/>
    <dbReference type="KEGG" id="tba:TERMP_00085"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.85"/>
    <dbReference type="eggNOG" id="arCOG01351">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_1_2_2"/>
    <dbReference type="OMA" id="LMFYGPG"/>
    <dbReference type="OrthoDB" id="102435at2157"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_3" evidence="10">
        <location>
            <begin position="10"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine_dh" evidence="9">
        <location>
            <begin position="156"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="333" mass="37140" checksum="26BD2E3F90045EA9" modified="2011-05-03" version="1">MTEVFLSFIGFGNVGRGVARVLIEKAEQFRIKYGLKFRIVSISDSKATIWDESGVDLKDALMVKETFGSLDKWGNDYEIYQMSPMEVVKEVESDVVVDVTNDVNAWKWHMEAFRHGRHVVTSNKPPLVFHFMELTQEAYMRRVNYRFEATVMAGTPIITLLQESLLGDEILSIRGVFNGTTTFILSQMERGLSFEEALKKAQELGIAERDPSTDIKGIDAAYKATILHNVAFYPISFEKLKIRGIAEISMREIERAKKEGKVIRLVAEVKKGEVSVEPKTVPKDSSLAVYGTQNVAVIETDLLGKLIVKGAGAGVKETASAVVSDIIKAVIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHA8</accession>
    <name>F0LHA8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl4</name>
        <name evidence="5" type="ordered locus">TERMP_00092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466368.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00092"/>
    <dbReference type="EnsemblBacteria" id="ADT83070">
        <property type="protein sequence ID" value="ADT83070"/>
        <property type="gene ID" value="TERMP_00092"/>
    </dbReference>
    <dbReference type="GeneID" id="26135408"/>
    <dbReference type="KEGG" id="tba:TERMP_00092"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.93"/>
    <dbReference type="eggNOG" id="arCOG04071">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026535_0_0_2"/>
    <dbReference type="OMA" id="WHQKVNV"/>
    <dbReference type="OrthoDB" id="65833at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_A">
        <property type="entry name" value="Ribosomal_L4_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_L4/L1e_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_L4_euk/arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019970">
        <property type="entry name" value="Ribosomall_L4-archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="PTHR19431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03672">
        <property type="entry name" value="rpl4p_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="255" mass="28753" checksum="41882F0C76B20554" modified="2011-05-03" version="1">MKVKVFSLNGEPIEEIELPKVFETPFRPDLIRRAVIASWTHRIQPQGRDPMAGKRRVTENIGKGHGMARVERIKTAPRFAAFVPFARGGRRAHPPKVEKIIWEDINRKEKKLALMSAIAATANYDLVRARGHIIDNVPQIPLIVEDELEKIGKTRETREIFKKLGIWDDIERAKKNTKVRAGKGKMRGRRYKKAKGPLIVVAKNEGIILGARNHPGVDVVLVDNLGVEVLAPGTHPGRLTIWTKGAIERLREIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHB7</accession>
    <name>F0LHB7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rps17</name>
        <name evidence="4" type="ordered locus">TERMP_00101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466377.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00101"/>
    <dbReference type="EnsemblBacteria" id="ADT83079">
        <property type="protein sequence ID" value="ADT83079"/>
        <property type="gene ID" value="TERMP_00101"/>
    </dbReference>
    <dbReference type="GeneID" id="26135417"/>
    <dbReference type="KEGG" id="tba:TERMP_00101"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.102"/>
    <dbReference type="eggNOG" id="arCOG04096">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_0_3_2"/>
    <dbReference type="OMA" id="KKYERYE"/>
    <dbReference type="OrthoDB" id="108145at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_A">
        <property type="entry name" value="Ribosomal_S17_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_S17_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019978">
        <property type="entry name" value="Ribosomal_S17_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="111" mass="12976" checksum="003D26A8D83B4CA0" modified="2011-05-03" version="1">MRDIGLRIQPPAEKCDDPKCPWHGHLKIHGRVFEGIVVSDKPRRTVTVERQYYHYLRKYERYELRRSKIHAHNPPCINAKAGDRVLIAETRPLSKTKHFVVVAVLQKAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHD4</accession>
    <name>F0LHD4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467559.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01286"/>
    <dbReference type="EnsemblBacteria" id="ADT84261">
        <property type="protein sequence ID" value="ADT84261"/>
        <property type="gene ID" value="TERMP_01286"/>
    </dbReference>
    <dbReference type="GeneID" id="26136769"/>
    <dbReference type="KEGG" id="tba:TERMP_01286"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1288"/>
    <dbReference type="eggNOG" id="arCOG00586">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_4_2"/>
    <dbReference type="OMA" id="RVWAVAN"/>
    <dbReference type="OrthoDB" id="72034at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="258" mass="28889" checksum="3136D01FAA3BC9C9" modified="2011-05-03" version="1">MAKVISIANQKGGVGKTTITMNLGFALANMGRRVLLVDIDPQFNLTFGLIGMEVLNYEDNNVGTLMTRESRVEDSIIEIRENLHLIPSHLNLSAKEIEIINAYNRERRLEKALKSVLPEYDYVLIDNPPSMGIFLVNSLTTSDYVLIPLELSYFGVIGMQLMFNLMKMIKEETNENLTLLGLIPNKFTRQTKVPATRLKELKETYPNAPLLTTIPKSVALEKAQSQGISIFEFEGDGRAAKAFLKLAKEVIALVEGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHE3</accession>
    <name>F0LHE3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Circadian clock KaiC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467568.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01295"/>
    <dbReference type="EnsemblBacteria" id="ADT84270">
        <property type="protein sequence ID" value="ADT84270"/>
        <property type="gene ID" value="TERMP_01295"/>
    </dbReference>
    <dbReference type="GeneID" id="10041611"/>
    <dbReference type="KEGG" id="tba:TERMP_01295"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1297"/>
    <dbReference type="eggNOG" id="arCOG01174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_4_1_2"/>
    <dbReference type="OMA" id="MGSHSIT"/>
    <dbReference type="OrthoDB" id="55361at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030665">
        <property type="entry name" value="KaiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039117">
        <property type="entry name" value="KaiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="KaiC" evidence="3">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_2" evidence="2">
        <location>
            <begin position="233"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="KaiC" evidence="3">
        <location>
            <begin position="235"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="452" mass="51248" checksum="CC2E5B88BFE5A348" modified="2011-05-03" version="1">MKTGIEFFDETIIREGFPEGSLIIVAGEPGTGKTIFTSTIIHNGLEKFGEKGMYISLSETKEDFYDEMKRLGMDFEKYEKSGLFRFMDLVTVTPDVIEKEIELIMKEILSFRPKRIVIDSITALTQLLGTEKTRIFLHTTLGRFIKSFGAVAFLIAEKPLGKETIGHGVEEFVVDGVIVLKYISLGEVRRRVMEIPKMRKRSIEKSQYEYVITDRGIEFLAIPELIRGQGDASEEKISTGIKELDAILDGGVYRGSITLIVGMTGTGKTTFGLHFAIANALQGRKAIYISFEESVGQLKRAARRYGMPVDEVLDKTLKMFSWVPEAKTPVHTFLKIREIIDEHKPEVLVIDSLTSLREHMNETELEKMLRYLSLIIKQYGVATYITLNAETDFETVPFTKASTLSDNIIGLKYVIKNELIERRLAVIKARGSNHSRKIHKYDITDKGVMIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHF8</accession>
    <name>F0LHF8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01310"/>
    <dbReference type="EnsemblBacteria" id="ADT84285">
        <property type="protein sequence ID" value="ADT84285"/>
        <property type="gene ID" value="TERMP_01310"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01310"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1311"/>
    <dbReference type="eggNOG" id="arCOG01863">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130237_0_0_2"/>
    <dbReference type="OMA" id="VQCEMCG"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004451">
        <property type="entry name" value="CHP00270"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00270">
        <property type="entry name" value="TIGR00270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="102"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="189" mass="22277" checksum="6305ECA594DEF3F6" modified="2011-05-03" version="1">MRERIEQEKVVLMGKAKPKICEICGAEIRGQGHTVKIEGAELLVCSNCYRKYGRKKPGTFSIMPTGREPRRTYKPKPRPQKRPYRERPLYTEDIVEDYAERVYQAIQRSKMSYEELSHKVGLSVNVLRRIAHGEYMPTIEEAKKLERYFKIKLIERVEEVHEEKISIPKDYEPTLGDIARIKIKKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHG1</accession>
    <name>F0LHG1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylpolyamine aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467586.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01313"/>
    <dbReference type="EnsemblBacteria" id="ADT84288">
        <property type="protein sequence ID" value="ADT84288"/>
        <property type="gene ID" value="TERMP_01313"/>
    </dbReference>
    <dbReference type="GeneID" id="10041629"/>
    <dbReference type="KEGG" id="tba:TERMP_01313"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1314"/>
    <dbReference type="eggNOG" id="arCOG00324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_8_2_2"/>
    <dbReference type="OMA" id="GRAMGFC"/>
    <dbReference type="OrthoDB" id="34461at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="1">
        <location>
            <begin position="19"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="334" mass="37538" checksum="961C98E6C1B885D8" modified="2011-05-03" version="1">MLRILYSSIFKEHKPLDYHPENPNRLDFAIEGLKAKNLWQNVVKPNPANIEEILEVHFENYVERIRKASQMGFHYIDPDTYVCEKTWNAAIYAFGAAREAALMALEEKGIYLALVRPPGHHAGKSGRAFYASTLGFCIFNNIAGAAKLLESLEGNALIIDFDVHHGNGTQEIFWNDANVVHIDLHERDIYPWSGYEWEVGGKDAEGTKINIPMTSYSGDDDYMYAWKEIVMPIVDVIKPKVILISAGFDAFKGDGLATIQLTEEFYRFAGASLSGYSLSVVLEGGYGIGLEKGLPAFVEGYIKGETGKEIIMPSYETLKVVGKVKEILREWWEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHH2</accession>
    <name>F0LHH2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467597.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01324"/>
    <dbReference type="EnsemblBacteria" id="ADT84299">
        <property type="protein sequence ID" value="ADT84299"/>
        <property type="gene ID" value="TERMP_01324"/>
    </dbReference>
    <dbReference type="GeneID" id="10041640"/>
    <dbReference type="KEGG" id="tba:TERMP_01324"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1325"/>
    <dbReference type="eggNOG" id="arCOG05472">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086890_0_0_2"/>
    <dbReference type="OMA" id="HARYVIV"/>
    <dbReference type="OrthoDB" id="64032at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="193" mass="22606" checksum="426D1CBB5697F50B" modified="2011-05-03" version="1">MGISITPHGIKITRELSELDNFVLDVVKLIEKYSPYVIVSGYVTILFGRSRGTEDVDFVVERIPKEEFIKFCRDAQGSGFEFINPEDCFGLYEMLDGRMSIRMARRGEIIPNAEIKFPKDFFHQEALKKRISVILNDKQIYISPIELQIAYKLYLGSDKDVEDAYYLYELFKENLNRRLLHDYAKRLDIEVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHH4</accession>
    <name>F0LHH4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01326"/>
    <dbReference type="EnsemblBacteria" id="ADT84301">
        <property type="protein sequence ID" value="ADT84301"/>
        <property type="gene ID" value="TERMP_01326"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01326"/>
    <dbReference type="HOGENOM" id="CLU_3283047_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="40" mass="4564" checksum="0340A87E45A6E48B" modified="2011-05-03" version="1">MRIFEQTHLDGISLKIVCCDKTQMRNKVLFSSAVLLLVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHJ2</accession>
    <name>F0LHJ2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <shortName evidence="10">AdoMetDC</shortName>
            <shortName evidence="10">SAMDC</shortName>
            <ecNumber evidence="10">4.1.1.50</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="10">S-adenosylmethionine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">S-adenosylmethionine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="10" type="primary">speH</name>
        <name evidence="11" type="ordered locus">TERMP_01344</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="10"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467617.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01344"/>
    <dbReference type="EnsemblBacteria" id="ADT84319">
        <property type="protein sequence ID" value="ADT84319"/>
        <property type="gene ID" value="TERMP_01344"/>
    </dbReference>
    <dbReference type="GeneID" id="26136828"/>
    <dbReference type="KEGG" id="tba:TERMP_01344"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1344"/>
    <dbReference type="eggNOG" id="arCOG00279">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125470_2_3_2"/>
    <dbReference type="OMA" id="FMCGACD"/>
    <dbReference type="OrthoDB" id="106151at2157"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006557">
        <property type="term" value="P:S-adenosylmethioninamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00464">
        <property type="entry name" value="AdoMetDC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042286">
        <property type="entry name" value="AdoMetDC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042284">
        <property type="entry name" value="AdoMetDC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="PTHR33866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="SSF56276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 10" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023285755" description="S-adenosylmethionine decarboxylase beta chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023285754" description="S-adenosylmethionine decarboxylase alpha chain" evidence="10">
        <location>
            <begin position="69"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="10">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="10">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="10">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="10">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="10">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT84319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="124" mass="13916" checksum="9FFE46DA56855299" modified="2011-05-03" version="1">MTQVTVDNPIGMHVVLDLYECDPQILDDIERIEEILTKAAEIANATIIDKRFHKFSPQGVSGVVVVSESHIAIHTWPEHGYAAVDVYTCGDHTMPLKASEYIIRALKCKRPTIVKLDRGLLFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHN4</accession>
    <name>F0LHN4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polbeta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466416.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00141"/>
    <dbReference type="EnsemblBacteria" id="ADT83118">
        <property type="protein sequence ID" value="ADT83118"/>
        <property type="gene ID" value="TERMP_00141"/>
    </dbReference>
    <dbReference type="GeneID" id="10040459"/>
    <dbReference type="KEGG" id="tba:TERMP_00141"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.142"/>
    <dbReference type="eggNOG" id="arCOG02107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_1_2_2"/>
    <dbReference type="OMA" id="RYYYDYL"/>
    <dbReference type="OrthoDB" id="115826at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="125" mass="14992" checksum="F75257235D8BD82A" modified="2011-05-03" version="1">MKIEDAVRRILDLDKEGKVKFIILYGSHARGEARKDSDVDLCIYYDGTKREAFEFRMKILGELPDNYDVQIFNLLPIFLRRECLKGVVLFCRDWGFLYDIAYKTIEEFEDFKRYYYDYIGLEAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHQ6</accession>
    <name>F0LHQ6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex component Rrp41</fullName>
            <ecNumber evidence="6">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rrp41</name>
        <name evidence="9" type="ordered locus">TERMP_00163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'-&gt;5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNase PH family. Rrp41 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00163"/>
    <dbReference type="EnsemblBacteria" id="ADT83140">
        <property type="protein sequence ID" value="ADT83140"/>
        <property type="gene ID" value="TERMP_00163"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00163"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.164"/>
    <dbReference type="eggNOG" id="arCOG01575">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_0_0_2"/>
    <dbReference type="OMA" id="KGKGQGW"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11366">
        <property type="entry name" value="RNase_PH_archRRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00591">
        <property type="entry name" value="Exosome_Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011807">
        <property type="entry name" value="Rrp41"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02065">
        <property type="entry name" value="ECX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6" id="KW-0271">Exosome</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="7">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="8">
        <location>
            <begin position="156"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="246" mass="27371" checksum="4E4550F85BC33DC6" modified="2011-05-03" version="1">MGKPEDIKLIDENGRRIDGRKKYELRPIKMEVGVLKNADGSAYIEWGKNKILAAVYGPREIHPKHLQRPDRAILRVRYNMAPFSVEERKKPGPDRRSVEISKVIRGALEPAIILELFPRTAIDVFIEVLQADAGTRVAGITAASLALADAGIPMKDLVSACAAGKIEGQIVLDLNKEEDNYGEADVPVAIMPIKNDITLLQMDGYLTREEFLEAVRLAIKGAKAVYQKQREALKEKYIKIAQEVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHT5</accession>
    <name>F0LHT5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH-type transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GbsR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467633.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01360"/>
    <dbReference type="EnsemblBacteria" id="ADT84335">
        <property type="protein sequence ID" value="ADT84335"/>
        <property type="gene ID" value="TERMP_01360"/>
    </dbReference>
    <dbReference type="GeneID" id="10041676"/>
    <dbReference type="KEGG" id="tba:TERMP_01360"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1360"/>
    <dbReference type="eggNOG" id="arCOG02795">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1674075_0_0_2"/>
    <dbReference type="OMA" id="RWGYDRT"/>
    <dbReference type="OrthoDB" id="95368at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026282">
        <property type="entry name" value="MJ1563"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006707">
        <property type="entry name" value="MJ1563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="157" mass="18397" checksum="C63925514D6BC929" modified="2011-05-03" version="1">MKGEDRESKKFIEIVERMMIRWGYTHTDGKVYALLLLNEKPLTINELVQLTGLSRSSVSTSLNKLARDYLVIVRKNGKTKLFYPIPAFLEKFLKQPKEILEKEVKPLKNIVSILMKKEQSFEQKVRFEEILSDLNALECVLSKIIKMEEEEVECFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHT6</accession>
    <name>F0LHT6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain heme biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467634.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01361"/>
    <dbReference type="EnsemblBacteria" id="ADT84336">
        <property type="protein sequence ID" value="ADT84336"/>
        <property type="gene ID" value="TERMP_01361"/>
    </dbReference>
    <dbReference type="GeneID" id="10041677"/>
    <dbReference type="KEGG" id="tba:TERMP_01361"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1361"/>
    <dbReference type="eggNOG" id="arCOG00940">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_0_2"/>
    <dbReference type="OMA" id="IVWNFTN"/>
    <dbReference type="OrthoDB" id="18533at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034391">
        <property type="entry name" value="Cmo-like_SPASM_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01387">
        <property type="entry name" value="BtrN-like_SPASM_domain_contain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="124"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="535" mass="60168" checksum="EB8FEA00A1BC89F2" modified="2011-05-03" version="1">MKGGSKSKGNQLTAALMAFKIILGNPLARLLIRPALKKYEIEGRKLPALYWALSIYAGESINCPLMIRFQAEIIKTLLKLGIKIAKGDEEAVKEALLRDPHIRRGIWVVLEGIARYGITVPQRLAGPFLIVWNFTNMCNLRCQHCYQRADKPLSSELSLKEKLNLVEQLDKAGVAAVALSGGEPTIHPHFLRIVRELSNRGIHTSVATNGWTFANKEEFKRAINAGIKYVEVSVDSANPERHDKFRGIPGSWEHAIKALENAVELGVSHGMATIMSKETFNEIDEILDLAESIGVKRVIFFNFVPTGRAERIVTKDLSPEEREEFMKEIYKQMKRRKIEILTTAPQYARVTFLISEGKSITPAHFYIGETNSVKTLAEFIGGCGAGRIYAGIEPDGTIVPCVFLPLPVGNIRTKPFKEIWDTSKIFNILRDRNNFTGTCRSCSYRNICGGCRARAYYYTLNLMGDDPGCIINRRIWDDILKHKKIRGITGINWVDENVAIRTPVLHLPSYYATLGIVGERSLRSNWEKTVKEIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHU4</accession>
    <name>F0LHU4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01369"/>
    <dbReference type="EnsemblBacteria" id="ADT84344">
        <property type="protein sequence ID" value="ADT84344"/>
        <property type="gene ID" value="TERMP_01369"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01369"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1369"/>
    <dbReference type="HOGENOM" id="CLU_3338670_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="37" mass="4377" checksum="F4CE4C2A1DDFBE30" modified="2011-05-03" version="1">MPKEVLIIFAVGWLRAIVVGLKRMLIFVQSFTQFYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHU9</accession>
    <name>F0LHU9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467647.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01374"/>
    <dbReference type="EnsemblBacteria" id="ADT84349">
        <property type="protein sequence ID" value="ADT84349"/>
        <property type="gene ID" value="TERMP_01374"/>
    </dbReference>
    <dbReference type="GeneID" id="10041690"/>
    <dbReference type="KEGG" id="tba:TERMP_01374"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1374"/>
    <dbReference type="HOGENOM" id="CLU_346363_0_0_2"/>
    <dbReference type="OMA" id="PPMPETN"/>
    <dbReference type="OrthoDB" id="9496at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="815" mass="88757" checksum="67286373770C6383" modified="2011-05-03" version="1">MSAVKKSLLGVALLLLLTVPQALSSKVLVWNTGGWILHPRFSPDGLYFSDYSGRLGLKTSETHFIFWRLPIMPNGMSVSDRIYISADWGPPAVFDPINDTVYIWSYPGVSFVHVFAVPGRAYYAGKINESGGIGVLTGNDLVFYDFSSAGIVKVYDTYATPEGIYFTAELNESPHGGIGLLQPENKTFILWRFPSNYSRLIPDGIVLGHDGFLYAAIMEGDATGLVRFSPENGSFFFKELSGRPLHVKAFGNRILLMASEGFLALIDPLNVTWTLESVLEGKEYRFETAFLGGPTKTENVTREEREIKPEYRDVVKEELNGIILYNILGTHDFGGGYVGEGGALVLVDELRPKVHLLYENGTVRAWVTPEDIFTAPVFLYVNEKLVRWGKEIVWNATFLAGEYNLTAVYFDGEDVYMNTTTVVSDLRPGLLWSRSVKVEGGTVIYGMASHPGVPVNVSGRVVWTDERGYFSFFVANATETETTPVEEERGPNHWSVALLIFAVPIGVAGAVLIGRKERKGYALVVIALILTALYFTVPKAPGEAGEEKPLTLSLIVVMPPGFYASNVTVIVDGENTGRTNSTGMLEVPIDYGLHEIRLLSGGAETRFEVAMAENRTLTVPFFPGVNATLTNGPGYAGFSASVGSVTLSSMHPGAYPSGPMKGGEAGGELSSNRCDLCKLKAAMVGAVEGEACKLCCLQSKNFGPAVVFNYYFHLVWAAIERFGCITPWPPMPETNSIVGGAAINSYADDLENSLPKPGWGSIHPCLSPLDGLDPANPGTICSALECADIKFDCNCYVTCFLGPFKMWDAYITCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHV6</accession>
    <name>F0LHV6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467654.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01381"/>
    <dbReference type="EnsemblBacteria" id="ADT84356">
        <property type="protein sequence ID" value="ADT84356"/>
        <property type="gene ID" value="TERMP_01381"/>
    </dbReference>
    <dbReference type="GeneID" id="10041697"/>
    <dbReference type="KEGG" id="tba:TERMP_01381"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1381"/>
    <dbReference type="eggNOG" id="arCOG10657">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2079544_0_0_2"/>
    <dbReference type="OMA" id="VRYTHPI"/>
    <dbReference type="OrthoDB" id="117716at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="115" mass="12873" checksum="4C249B72C21B4FDE" modified="2011-05-03" version="1">MKRLLFLFVVVFVLFLFFSVNQKSGQDAFVGVLIEGRPVNAENAEVLADTDCIPNEAYTTLTCTAIIQANDQIIKVRYTHPIKTPCLSKGDKVNISMKRDSTVEIIRLGKPSMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHW8</accession>
    <name>F0LHW8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01393"/>
    <dbReference type="EnsemblBacteria" id="ADT84368">
        <property type="protein sequence ID" value="ADT84368"/>
        <property type="gene ID" value="TERMP_01393"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01393"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1393"/>
    <dbReference type="HOGENOM" id="CLU_2204240_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="107" mass="11745" checksum="2CD4092AC47DE774" modified="2011-05-03" version="1">MSSFGTGGTGGTVLGYCLLYLLDFETSLSRCFIRCPNHMAITMNIINPAALPKMADTMTINTKSLTRPSRMSSSMNQCPMCTRIPPLPVETGRLCHYLTSFDIVLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHX4</accession>
    <name>F0LHX4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-heptaprenyl-1/4-naphthoquinone methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01399"/>
    <dbReference type="EnsemblBacteria" id="ADT84374">
        <property type="protein sequence ID" value="ADT84374"/>
        <property type="gene ID" value="TERMP_01399"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01399"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1399"/>
    <dbReference type="eggNOG" id="arCOG01792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092709_0_0_2"/>
    <dbReference type="OMA" id="NYMFDLI"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="9"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="195" mass="22087" checksum="8E32AD12E0A2887B" modified="2011-05-03" version="1">MDIKKGEIVLEIGFGTGHCLKKMAELVGKEGKVYGIDISSGMLEVSRKRLEKAGLLDRVELYCGDASKLPYEDNKFDAVFMSFTLELFDTPEIPEVLNEVRRVLKPGGRLGVVSMSKEGRGLLMRIYEWLHEKLPQYLDCRPIHLSQTLKDAGFLVMHEEVRRIFGLPIEIIIALKPGRKNHGRVAVRKGLRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHY6</accession>
    <name>F0LHY6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alkyl hydroperoxide reductase C</fullName>
            <ecNumber evidence="3">1.11.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_01411</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:62628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.11.1.26"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.11.1.26" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467684.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01411"/>
    <dbReference type="EnsemblBacteria" id="ADT84386">
        <property type="protein sequence ID" value="ADT84386"/>
        <property type="gene ID" value="TERMP_01411"/>
    </dbReference>
    <dbReference type="GeneID" id="10041727"/>
    <dbReference type="KEGG" id="tba:TERMP_01411"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1411"/>
    <dbReference type="eggNOG" id="arCOG00312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_21_3_2"/>
    <dbReference type="OMA" id="WWPKDFT"/>
    <dbReference type="OrthoDB" id="98508at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102039">
        <property type="term" value="F:alkylhydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="9">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT84386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="189" mass="21427" checksum="24D2232A2242C272" modified="2011-05-03" version="1">MVKVGEIVPDFEADAYLPEKDDIGKVKLSDYRGKWVVLAFYPADFTFVCPTELEELADYYEEFKKEGAEILSVSTDTAYVHKAWHDTSPAIKKIRYPMLADPAGKISRLFGTYIEDEGVSWRATFIIDPDGKVVHMEMHDLSIGRSAKEILRRLRASKYVREHPGQVCPASWEPGKETLKVSLDLVGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHY8</accession>
    <name>F0LHY8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467686.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01413"/>
    <dbReference type="EnsemblBacteria" id="ADT84388">
        <property type="protein sequence ID" value="ADT84388"/>
        <property type="gene ID" value="TERMP_01413"/>
    </dbReference>
    <dbReference type="GeneID" id="33334190"/>
    <dbReference type="GeneID" id="58919011"/>
    <dbReference type="KEGG" id="tba:TERMP_01413"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1413"/>
    <dbReference type="eggNOG" id="arCOG06386">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176022_4_1_2"/>
    <dbReference type="OrthoDB" id="131046at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021309">
        <property type="entry name" value="DUF2892"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11127">
        <property type="entry name" value="DUF2892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="65" mass="7052" checksum="5A45D9160D316F90" modified="2011-05-03" version="1">MERNEGTLDRLLRIVIGIVLLGIWAGMNVPYETVLLIVGLIALVTGLTGFCAIYKLLGISTCKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI26</accession>
    <name>F0LI26_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small primase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT83180">
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        <property type="gene ID" value="TERMP_00203"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00203"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.203"/>
    <dbReference type="eggNOG" id="arCOG01486">
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    <dbReference type="HOGENOM" id="CLU_140789_3_0_2"/>
    <dbReference type="OMA" id="VMILTDF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="94" mass="10930" checksum="D88410717BB3501A" modified="2011-05-03" version="1">MALRKLGVRAEIIRLSRLPLSEVALIASQYHEVMILTDLDRKGEELAKKLTQYLEGYKCRVDTETRKELKMIAKKDIKGIEDLYGLYTKVTLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI37</accession>
    <name>F0LI37_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00214"/>
    <dbReference type="EnsemblBacteria" id="ADT83191">
        <property type="protein sequence ID" value="ADT83191"/>
        <property type="gene ID" value="TERMP_00214"/>
    </dbReference>
    <dbReference type="GeneID" id="10040532"/>
    <dbReference type="KEGG" id="tba:TERMP_00214"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.214"/>
    <dbReference type="eggNOG" id="arCOG07154">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2165389_0_0_2"/>
    <dbReference type="OMA" id="LIEYYEW"/>
    <dbReference type="OrthoDB" id="126017at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="98" mass="11607" checksum="DB7144FADEF0D770" modified="2011-05-03" version="1">MATKIKNSEGVKLLINEVAKAVGVSPKELIEYYEWKANLKKLKTKKITRKEIQQVLNEWKSKRTGISEEKAIEIYYEAEEEIKRWKEIERKLKKLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI55</accession>
    <name>F0LI55_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466507.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00232"/>
    <dbReference type="EnsemblBacteria" id="ADT83209">
        <property type="protein sequence ID" value="ADT83209"/>
        <property type="gene ID" value="TERMP_00232"/>
    </dbReference>
    <dbReference type="GeneID" id="10040550"/>
    <dbReference type="KEGG" id="tba:TERMP_00232"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.232"/>
    <dbReference type="eggNOG" id="arCOG07627">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1025346_0_0_2"/>
    <dbReference type="OMA" id="VDKYMYS"/>
    <dbReference type="OrthoDB" id="134248at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="256" mass="29925" checksum="0E92DF03B6DD65BC" modified="2011-05-03" version="1">MKRGLAVLILVSLLVLAFGCMSTKPPTKESVAKAIEDVDRYEFQGELRDSGSKMINNFTSYIRGGFYYSREEAYWEIEIHEEKAVRYINETILGDLLYYSYILKAGGRIVEDSQVTETLQEYFDSIKDNTNITSPEDLKWKILKGSDPMKNPLYFIKELLENSNITKIEKTNKGHLIEFTFKIQKRYSNFGNVLYITNKGNGKMLIKNNLPIEAEISAMRIAQTNENHSTIRKYDLRISFFYEYKRPEWVRRVTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI73</accession>
    <name>F0LI73_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466525.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00250"/>
    <dbReference type="EnsemblBacteria" id="ADT83227">
        <property type="protein sequence ID" value="ADT83227"/>
        <property type="gene ID" value="TERMP_00250"/>
    </dbReference>
    <dbReference type="GeneID" id="10042537"/>
    <dbReference type="KEGG" id="tba:TERMP_00250"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.250"/>
    <dbReference type="eggNOG" id="arCOG01434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_0_2"/>
    <dbReference type="OMA" id="DDVNRFC"/>
    <dbReference type="OrthoDB" id="16594at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="1">
        <location>
            <begin position="76"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="348" mass="39372" checksum="F4B35567F448011B" modified="2011-05-03" version="1">MLKCQKCGKTYEKFRLVCECGGLLDVVMEFKGSFERLLKKEYLDVRRYLNFLPINEGVLPKLVLPITPTVEMDVENVKVLFKLEYLMPSGSFKDRGTYVTISKLKEEEIKEISIDSSGNAAISFALFGKAEGIKVHVFIPEHTSKGKKRILKLLGAEIHEIKGSRMEVHWKAREFKDAFYISHWYNPYFLEGTKIAAYEIFEQIGEVDYALVPTGSGTLFLGLYKGFKEIKNFEKAKMPKLIAVQAEGYESLCKRSKRKSKLAEGIAIPEPPRKEQMLKALKETEGFCMSVSDSEIDRAFNDLISMGFLIEPTSAVVFAAFKKLLERGEFEKGSKVLLPLTGSGLKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI94</accession>
    <name>F0LI94_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467722.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01449"/>
    <dbReference type="EnsemblBacteria" id="ADT84424">
        <property type="protein sequence ID" value="ADT84424"/>
        <property type="gene ID" value="TERMP_01449"/>
    </dbReference>
    <dbReference type="GeneID" id="10041765"/>
    <dbReference type="KEGG" id="tba:TERMP_01449"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1449"/>
    <dbReference type="eggNOG" id="arCOG07530">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402612_0_0_2"/>
    <dbReference type="OMA" id="HETSTPG"/>
    <dbReference type="OrthoDB" id="38108at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="683" mass="76398" checksum="4894A05E3A2DA666" modified="2011-05-03" version="1">MRLRIIFGSLVLIFLYTASLGPLSVSGLPKDEFNPIKDSMEALGIGITDFYNDTNLISISGMYTGKDGLNAKVTVKLRRYSSSEDVREAYDREINSPLSCLNARDEPAMLYSKKSTEGNPSCYRFSTMIRQEDSGKYYRSNPWFSYEKYVLSGNYLLAITIQGKWDNERYNDGNYSRVVCTHGANSDCWVEYDENAYANYLKLLDSLRRETEALSNSIGERVTGSALPLMAPKGSNTSTAGVNESPAEYSVRIYSPSDGAILKQLFEGYFTISLWADVRGKGAENLYAVVTLPDGSKRRVEVLGDSIADIISVDDPSIKGGILKVDLYGEINSAKKLLASDSVRVSFISKEVPGDGIDNDLDGLTDCDDPDIATCEACVQQKKLEWAESLMERHIDYLKRMIEATPGMRSVYEVYIDELHAIHDRYRDDPGRMAEEMNAYMEGKVYQNQKINDYLSIFKDDPEKRYQLRQIAIKYRYDPIARDIAMRNFIYENSKSEAEKTATMNAILTGVLNPPKWLVGGQYGSGGALDWAQFVATNFETAGNTVKLKGAEKVKFFTTPTKIYLVALDAKALMDHANEVKKMNLDERTKVSIIVLDGATKIGKLLDPTGYFGNMADATVGSLINLRKKIEERNQGWFTWNGYVLHETSTPGIYEDYETGKKFKRVGGGWLGGANFVEVSKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIB3</accession>
    <name>F0LIB3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467741.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01468"/>
    <dbReference type="EnsemblBacteria" id="ADT84443">
        <property type="protein sequence ID" value="ADT84443"/>
        <property type="gene ID" value="TERMP_01468"/>
    </dbReference>
    <dbReference type="GeneID" id="26136958"/>
    <dbReference type="KEGG" id="tba:TERMP_01468"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1468"/>
    <dbReference type="eggNOG" id="arCOG07114">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2985877_0_0_2"/>
    <dbReference type="OMA" id="DHYTLGY"/>
    <dbReference type="OrthoDB" id="127309at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="60" mass="6979" checksum="2CABCDF95830EF39" modified="2011-05-03" version="1">MVGFDHYTLGYLTFAFMSLTMLSGAFIFLNKNKKSFWVKMHIVLSVITYILMVLTILLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIC3</accession>
    <name>F0LIC3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467751.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01478"/>
    <dbReference type="EnsemblBacteria" id="ADT84453">
        <property type="protein sequence ID" value="ADT84453"/>
        <property type="gene ID" value="TERMP_01478"/>
    </dbReference>
    <dbReference type="GeneID" id="26136966"/>
    <dbReference type="KEGG" id="tba:TERMP_01478"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1478"/>
    <dbReference type="eggNOG" id="arCOG03072">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082058_2_1_2"/>
    <dbReference type="OMA" id="YTIGFKR"/>
    <dbReference type="OrthoDB" id="108209at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="123" mass="13295" checksum="CD5B0AF283E3CD67" modified="2011-05-03" version="1">MNGSIWVNFPFIVVALLLAVGFYTIGFKRNLIKVVIGIEILEGAVNLFLVALGYVKGGYAPIYTLAPPEAANPQNMVLPTPQALTLTSIVIGVAVSALMLAFAVNIYKRYGTLDVTKIRRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LID3</accession>
    <name>F0LID3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Energy-conserving NiFe-hydrogenase (Ferredoxin) beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467761.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01488"/>
    <dbReference type="EnsemblBacteria" id="ADT84463">
        <property type="protein sequence ID" value="ADT84463"/>
        <property type="gene ID" value="TERMP_01488"/>
    </dbReference>
    <dbReference type="GeneID" id="10041804"/>
    <dbReference type="KEGG" id="tba:TERMP_01488"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1488"/>
    <dbReference type="eggNOG" id="arCOG01552">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097415_1_0_2"/>
    <dbReference type="OMA" id="HYSIGIE"/>
    <dbReference type="OrthoDB" id="101801at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="1">
        <location>
            <begin position="35"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="172" mass="20174" checksum="1BE6AA608182A3D2" modified="2011-05-03" version="1">MTPEEFAERIKAKFEEISIRITENKLPHPRKRVWIEVDRERFKELVRFLKEVNPTAQFSIIIAEDRGDRLTAKYHWEMFWEQGESLSVIVGTSCPKNDPVLPTITDIFPSSLPYEREVQEFLGIKYEGIPDPRRLFLPDDFPEGIYPLRLDETGIKPDMVKNAGHPYRRGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIK7</accession>
    <name>F0LIK7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00304"/>
    <dbReference type="EnsemblBacteria" id="ADT83281">
        <property type="protein sequence ID" value="ADT83281"/>
        <property type="gene ID" value="TERMP_00304"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00304"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.304"/>
    <dbReference type="eggNOG" id="arCOG00726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121774_2_1_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="98" mass="11023" checksum="023CA3E82159DDCD" modified="2011-05-03" version="1">MALIEGANAIWKRCVLYQDIPLKTAEKLLGYLHSTKGIIIYEDPIEYLPKAEEIALENNVTVYDSLYIAQALKYGKLATSDEKQGKVAEKLGIVVFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIQ4</accession>
    <name>F0LIQ4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84506">
        <property type="protein sequence ID" value="ADT84506"/>
        <property type="gene ID" value="TERMP_01531"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01531"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1531"/>
    <dbReference type="HOGENOM" id="CLU_2204241_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="107" mass="11819" checksum="6ED8D8D2AD6CC051" modified="2011-05-03" version="1">MFLGMTGQMIRVIIGVKKVQEKAVSEGREFKEAFDMKRLVISMLIGATAGVLGIVSLYWGEQEITKEMALGLIAIGYSGTDFIEGLFRTKIQPMRKEKSTPSSTLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIS3</accession>
    <name>F0LIS3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor E</fullName>
            <shortName evidence="4">TFE</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">TFIIE subunit alpha homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Transcription initiation factor TFIIE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tfe</name>
        <name evidence="6" type="ordered locus">TERMP_01550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The winged helix domain is involved in binding to DNA in the preinitiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TFE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467823.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01550"/>
    <dbReference type="EnsemblBacteria" id="ADT84525">
        <property type="protein sequence ID" value="ADT84525"/>
        <property type="gene ID" value="TERMP_01550"/>
    </dbReference>
    <dbReference type="GeneID" id="10041866"/>
    <dbReference type="KEGG" id="tba:TERMP_01550"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1550"/>
    <dbReference type="eggNOG" id="arCOG04270">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100097_0_0_2"/>
    <dbReference type="OMA" id="DSGWLTY"/>
    <dbReference type="OrthoDB" id="75288at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01909">
        <property type="entry name" value="TFE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016481">
        <property type="entry name" value="TF_E_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="PTHR13097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006373">
        <property type="entry name" value="TF_E_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00373">
        <property type="entry name" value="TIGR00373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="171" mass="20456" checksum="939706EEB522CFDB" modified="2011-05-03" version="1">MPRRKNKELIEFAMDIGGEEAVEIIKALEKKGEATDEELAEMTGIRVNTVRKILYALYDHQLAEFRRTRDKETGWYYYYWHLETRRLPEIIRARKMQELKKLKQMLEEETSEIYYHCGTPGHPKLTFDEALEYEFQCPICGAMLMQYDNTKIVEELKKRIEQLEKELGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIU2</accession>
    <name>F0LIU2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01569"/>
    <dbReference type="EnsemblBacteria" id="ADT84544">
        <property type="protein sequence ID" value="ADT84544"/>
        <property type="gene ID" value="TERMP_01569"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01569"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1569"/>
    <dbReference type="eggNOG" id="arCOG04139">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2079966_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA_C" evidence="1">
        <location>
            <begin position="10"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="139" mass="15885" checksum="E49AB8EB2821EB3C" modified="2011-05-03" version="1">MPHDTQVSENIIGWKWIKALVNSAINPVGALLEVKNGFLLENEHLLAILMEIVKEGCRVAMQWGVEFEEHPLEILIDTLERTRENYNSMLQDLKRGKKTEIDYINGKIVEYAENIGLSAPMNNLLWALIKAKELLTQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIU8</accession>
    <name>F0LIU8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467848.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01575"/>
    <dbReference type="EnsemblBacteria" id="ADT84550">
        <property type="protein sequence ID" value="ADT84550"/>
        <property type="gene ID" value="TERMP_01575"/>
    </dbReference>
    <dbReference type="GeneID" id="10041891"/>
    <dbReference type="KEGG" id="tba:TERMP_01575"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1575"/>
    <dbReference type="eggNOG" id="arCOG02499">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02501">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02545">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03439">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03610">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG05189">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_240084_0_0_2"/>
    <dbReference type="OrthoDB" id="1563at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASH" evidence="1">
        <location>
            <begin position="286"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="CASH" evidence="1">
        <location>
            <begin position="569"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="CASH" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1727" mass="189893" checksum="85C599EA3CC082EA" modified="2011-05-03" version="1">MKKLGAFVIGILLVFSIMGTFYPVKGEGQCTPDNPCYITQCTMITQSGYYKLANDIVVNDISQLIPVNFDNEGNNAGLSCIAIYSEGVIIDGNGRKIILKIPMEERPPLALSAVYVESFETFAIAEEIKNLVIDGWDVGVDTGVSELRYTVEDIMNPSLEIVYSNHYVQFKIDAEKKTNFLLYNNTIRNTIVGIAIAGPVVSDPGILEGDVFGYLGDVLPTFSGLVENTFEDNIISVHISGTAAGGNVTVPFLIANNTVRRSYLGIYILTSVPAVREVGYFDKLPIATGPTLVNNEIVNNTQGVTIVASKRVGFINNSVRNNRFGVIIRGEKNLSKVINIEDEDNGILHCDVNCLSEYWIGITSNVTISGNEITNNTWGITISTAENLTISGNLIADNRDTYEEVSYTLPNGKEVGAYAIPSFSLYGIGLYLHNVSNSLIENNELFGNGIGPLTLEYLPFCDSCGYIADMARNHAPLGYIGALIDIEGENNTIRENYIHDNAGIGIYLRSRDELEKNVLVNDYISTIGTDGYFTDFEVKETTVNGRPVLMVKNAKNVLINNAGQVFVVNSSNVRIEGLEFQSYKATPVIVSGSSDVEIRAVNAKELEGIAGIYVQDSSGVRIVESNFERNYYASIGVRGSKDVLIEGNRFSENFGIPVLASGVEGLDIRENEAFSSGGGIVALNIENGRIADNRVHDAVMRKRLLGWSGEYYYDPVFGYYFYAVPVFERPYPWLPGINVGYSPIATVVVNGTGLEITSNEILENELAGIHVWNGKNVKITSNRVENNSRGGVILGLPVRTGKNIRVEEVIVRGNTFVNNGLSITGDYGSTFIDRLLIPEVPLVRNIRVEDNTVNGRPLVYLENEEGVEISNAGQVIAVNSTFTVKGLDVAFTDLPLLAIDSRVTIEDSSFQGRWGVAILRSNASIKNTRVEHGAEWVYYSYQDPVSEKIVNESTPLLSFGFHLVYSNATLLDVDVVSKVESNSSMTGIDVYAEPTRLYSPVSVKISGAKVENELTGIDVTAQDVEIMYSEIENSYIAINVKAYGKATIKGNGISNAAWGLCISPSKHGQVIIAENIIHNVEEAGINIGGKDDLSNFNVTGNEVRNSKYGLLVTVPYQGMGNGVISNNLFAENYYGLILGARTMENVEVHTNWLVNNTYGLTINAEKSEEVTVYNNYFDNYRDVYMSHTLGGVSFNTTVRPGRNIVGGPLIGGNYWERYDGTDENFDGVGDEPYQIAYGTYDYLPLIKFKPKSIGGEFPIIINEPGYYRLETDGENLSMEYAVLINASNVLLDGENHTLSGKELALYGVKVENTENVTVVNLNLKGWLLAGIYAENTVNARISGNTVTGNTAEGVDVRNSRGAEVSYNTIKDLTGDGVYLKDTVNSSISHNTVENAKGSGVELDTGSAGNLVWGNSISSGGVGFYLRPGSRSNVIFSNLVINNSLGVYVSNSKFNLIYNNYFDNARNVKVLGNVTNHWNVTKRGGTNILGGNLLGGNYWSELKDCEDKNLDGFCDVPYVIDDNNVDYLPLTVSSDTKPPEVEIIFPENTTYYQNVTEIKVRASDDHVVEKVMALVDGSIWVTMEFDGEYYIAKITLEEGHHAIEVYAYDAAGNVNSTRVEFTVEIKEIKTSIEDQETAQVSFAILTYLYYQWYQKAFEEFNVLYNSSSQNLDNETLARIKDLLVLAKKEYCWVEGHYQSLLQADVRALIHMRKAYLYIKKALELLGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIV5</accession>
    <name>F0LIV5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467855.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01582"/>
    <dbReference type="EnsemblBacteria" id="ADT84557">
        <property type="protein sequence ID" value="ADT84557"/>
        <property type="gene ID" value="TERMP_01582"/>
    </dbReference>
    <dbReference type="GeneID" id="26137218"/>
    <dbReference type="KEGG" id="tba:TERMP_01582"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1582"/>
    <dbReference type="eggNOG" id="arCOG02079">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_450291_0_0_2"/>
    <dbReference type="OrthoDB" id="3317at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="612" mass="70383" checksum="E12EEC735008911B" modified="2011-05-03" version="1">MKKLAIVLILMLITPSTIKAQPQKEEYLLTFSGYLGIGDVLTFGNYTLTVEDILTSPRTGIANTVLFKLRDNIVFNESEFSLQEGQEYQYKDVKIKLVVITLEDNPRALIRIYSKAVDVFYGDAHERSIFRYGPIKFMVLEIKNGTFLARYEKKGEVDYRYFGTGYYHWNELSIYVENITNKTVRLKIKAPKYAQYAIIRGAEIAIEKVDFGEVEIGSPFKLTITLRNVGNKNARFISVYLYSKEQIQEEQTQTLLPTITIPQFESSLPFAAYRESPIKYLEVLAPGEEKTVAFTLISSKNLKENVYPLYIRIEYQDEDGAKKSKEVQVGIPVEDRIRPKVIIEEFKIIPPIVQPDSNFTVRIKLRNIGNSVAKHVRVRVTGEKPEEEKQTAYPYFPSGGEAAQQEVDIFPIRKQSLLYFSEVNTTAEGKLYFKIKQVQRGIYPLYVTITYEDENGVVYKEETMFGVEVSAYPLLDLYIGNIWESGGKYNFEVYVVNEGKDVARGVTLDVTSKQLELFPIGQRYVGSIAGLDYDSVNFQILNKTIPKGEYVIHAKVYYKDEKGQEKTFEKDLVIRIPETLSYSERKPYEYYIGGGIILLFIIILLWRRKSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIW4</accession>
    <name>F0LIW4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPF0165 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467864.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01591"/>
    <dbReference type="EnsemblBacteria" id="ADT84566">
        <property type="protein sequence ID" value="ADT84566"/>
        <property type="gene ID" value="TERMP_01591"/>
    </dbReference>
    <dbReference type="GeneID" id="10041907"/>
    <dbReference type="KEGG" id="tba:TERMP_01591"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1591"/>
    <dbReference type="eggNOG" id="arCOG07152">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200885_0_1_2"/>
    <dbReference type="OMA" id="CKDIDYK"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008203">
        <property type="entry name" value="AF2212-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024069">
        <property type="entry name" value="AF2212-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01954">
        <property type="entry name" value="DUF104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="65" mass="7708" checksum="281B2C7D6140ED6A" modified="2011-05-03" version="1">MQVIEAIYEDGVLKPLKKLKLKEHSKVIIKIIDEEELEKILDSMVIEKVENIDYKKLKEAYYESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ05</accession>
    <name>F0LJ05_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">30S ribosomal protein S27e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps27e</name>
        <name evidence="5" type="ordered locus">TERMP_00374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3 4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466649.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00374"/>
    <dbReference type="EnsemblBacteria" id="ADT83351">
        <property type="protein sequence ID" value="ADT83351"/>
        <property type="gene ID" value="TERMP_00374"/>
    </dbReference>
    <dbReference type="GeneID" id="26135718"/>
    <dbReference type="KEGG" id="tba:TERMP_00374"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.374"/>
    <dbReference type="eggNOG" id="arCOG04108">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199465_0_0_2"/>
    <dbReference type="OMA" id="DCENEQV"/>
    <dbReference type="OrthoDB" id="129447at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_S27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_S27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="65" mass="7025" checksum="5ECD23F4787C8859" modified="2011-05-03" version="1">MALPKGLIPMPRSRFLRVKCIDCGNEQIVFSNPATKVRCLVCGATLVEPTGGKGIIKAKILEVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ18</accession>
    <name>F0LJ18_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466662.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00387"/>
    <dbReference type="EnsemblBacteria" id="ADT83364">
        <property type="protein sequence ID" value="ADT83364"/>
        <property type="gene ID" value="TERMP_00387"/>
    </dbReference>
    <dbReference type="GeneID" id="10040705"/>
    <dbReference type="KEGG" id="tba:TERMP_00387"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.387"/>
    <dbReference type="eggNOG" id="arCOG05037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014186_0_0_2"/>
    <dbReference type="OMA" id="FCKPFDI"/>
    <dbReference type="OrthoDB" id="55895at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="275" mass="31349" checksum="398E2611B8321B82" modified="2011-05-03" version="1">MADIGVIFYIEGLGNDRKALERAIEQVVKELKEETAIDVKRVNTEDIIENQEEDLLRYSAMVEVELEGSLRDVVDATMKYSPVVVEVLKPGRLEITAKELMKILGDVSLFMGKLMDQFGGLAAYPPLDQLPKPKIGYTEDEIEEFIVDERNIRYQFVIETYGKDKETVEETIMKAFYLEGCKINKFVVQVQEEREDKVYALVAAELLSSFETLMQLTAKYAPVAISILEPEIIDVTASELQNVLTDLAGFVHELVHRPLKKRLIEHDTIKFEISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ59</accession>
    <name>F0LJ59_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamin ABC transporter transmembrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467879.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01606"/>
    <dbReference type="EnsemblBacteria" id="ADT84581">
        <property type="protein sequence ID" value="ADT84581"/>
        <property type="gene ID" value="TERMP_01606"/>
    </dbReference>
    <dbReference type="GeneID" id="10041922"/>
    <dbReference type="KEGG" id="tba:TERMP_01606"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1606"/>
    <dbReference type="eggNOG" id="arCOG00163">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_5_2_2"/>
    <dbReference type="OMA" id="PLYLFQL"/>
    <dbReference type="OrthoDB" id="20616at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="53"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="342"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="540" mass="60620" checksum="8D9F0358FAAA363F" modified="2011-05-03" version="1">MRTKLILMIPITFLILFFYLPLISIIHEGLWDNGFTLKYLKAVLSNSYHRGIILFTIKQALASTLLTLALGLPGAYIFAKYDFPGKSFVKAILTVPFVMPSIMVALGFILLFGKQGFFTQLIGRDLGILYSWKAILIAHAFYNFPIVVRMVSSLWQRINPHYEEVAMSLGAKGFTLFRKVTLPMLLPGIFASSMLTFIFCFLSFSIPLILGGYKYATIEVDIFTSIMTLLDFKVGSALAIIQITLSFAFMYIYIKSLDMYAKAEEQRIFRQPQKLTLKELASLKGLLIGIYSLVVFIFIISPLLAVLYDSLIFQGKFSLEWYRRVFSAKYNPIFGANTLIAIKNSLLFGFSAVLLSTTIALIIAYALHRWQFKGKNIFEALVMLPLGSSAITLGLGYIRTFHKPPLELLGTWYIIVFAHTIIAYPFVLRAVSAVLRKIKPNLKEAALSLGAKEWQAFLKVELPLSLGGIIVGAIFAFAISIAELGATYMLYQPEYTTITIAVYRFLSARQWGSASALSVILMIVSAVSFMIIERIGEEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ62</accession>
    <name>F0LJ62_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IdeR/DtxR-like iron-dependent repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467882.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01609"/>
    <dbReference type="EnsemblBacteria" id="ADT84584">
        <property type="protein sequence ID" value="ADT84584"/>
        <property type="gene ID" value="TERMP_01609"/>
    </dbReference>
    <dbReference type="GeneID" id="10041925"/>
    <dbReference type="KEGG" id="tba:TERMP_01609"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1609"/>
    <dbReference type="eggNOG" id="arCOG02100">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_3_0_2"/>
    <dbReference type="OMA" id="SWDAIDR"/>
    <dbReference type="OrthoDB" id="110491at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="154" mass="18380" checksum="13685AA1C0CFC738" modified="2011-05-03" version="1">MEISKREEEYLEAMYLLYKRKGIIRIKDIAKKLRVRPPSVVDALKKLSEKGLVEYEKYDRILLTEKGREIAEKTYSKHLLLTEFFINILGIPPEIAEEDACQFEHYVHEITAERIREFAKYIQEQCPYVIKQFIKEHIEKEEKKSKDSSKVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ70</accession>
    <name>F0LJ70_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01617"/>
    <dbReference type="EnsemblBacteria" id="ADT84592">
        <property type="protein sequence ID" value="ADT84592"/>
        <property type="gene ID" value="TERMP_01617"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01617"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1617"/>
    <dbReference type="eggNOG" id="arCOG04138">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_775273_0_0_2"/>
    <dbReference type="OMA" id="QKPIKRM"/>
    <dbReference type="OrthoDB" id="107942at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="270"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="354" mass="42577" checksum="57296374934CA6E2" modified="2011-05-03" version="1">MEKALKEYEKRKKEAEDKQKRLKEQYTSKLLKKKKEILKNLEKLEKKEISKKIDDRIKKIVERERRSYVDTLRRTLERIENIEELGRFLPELSKLHISHGKYLLLVFEKEIYAINKLLKAVSEEYSEYIRKVSEISIEPIELDSILSDIEYARRQLENEEGDLRLLKNELGEKEREFKSKIAELEKELEKIESEIRTLNSLIAKDEIEIRSKISKLQKPIKRMRTGEKTANEILKDSSYGIEHPEEFLSFLIKIRSRLEGKYKQTADWILENLESKSKEIQERKRKLRELENKRAEILREKRKFESEIEAIKKQILEQERRIKRLKDKLLELEKELDESLSKLEKLLNTSIDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ74</accession>
    <name>F0LJ74_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467894.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01621"/>
    <dbReference type="EnsemblBacteria" id="ADT84596">
        <property type="protein sequence ID" value="ADT84596"/>
        <property type="gene ID" value="TERMP_01621"/>
    </dbReference>
    <dbReference type="GeneID" id="10041937"/>
    <dbReference type="KEGG" id="tba:TERMP_01621"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1621"/>
    <dbReference type="eggNOG" id="arCOG00132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046685_3_0_2"/>
    <dbReference type="OMA" id="WQAYFLK"/>
    <dbReference type="OrthoDB" id="59290at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="405" mass="45155" checksum="34BD590227554A70" modified="2011-05-03" version="1">MDVIKKYKVLYALMNTGFVGNILVIYYLAKGLTYTQIGIATAISTIGFFLFEVPTGVVGDKISRKKSVLIGLTLFPIGTIILIFLKNFPMLIAYSIITSLSVTFISGSLEAWLYDNLKHLGKEKEYRELMKEIKTITLPLSAITIVIGSLLAQEYGFKLPLILKLILEITTLMTALSIPEYEFKKPELAYHVHVLHSIKELMKPNLFWLIIMAITVTMSINQFRQYFEPYLGNILAQSLKTTIMETLGLLGLIEAIVKVLPKIIGVRLKEKWSAFAYSIAPVSIPILTALSVIYQNPVFIVILGVIATIINTAFAFNFGIELQVRISSEKRATLISLYSMISALIMAFFYGIYGFAVDKLGLAEARLVFALILSGIGLAFKGAQTIGILKEPLKLKHLQLHSKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJJ6</accession>
    <name>F0LJJ6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466760.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00485"/>
    <dbReference type="EnsemblBacteria" id="ADT83462">
        <property type="protein sequence ID" value="ADT83462"/>
        <property type="gene ID" value="TERMP_00485"/>
    </dbReference>
    <dbReference type="GeneID" id="26136000"/>
    <dbReference type="KEGG" id="tba:TERMP_00485"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.485"/>
    <dbReference type="eggNOG" id="arCOG01895">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_884604_0_0_2"/>
    <dbReference type="OMA" id="MQSGKTG"/>
    <dbReference type="OrthoDB" id="46548at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="268" mass="29636" checksum="95576A1E325D3517" modified="2011-05-03" version="1">MEIGVSIYPHFVNKDKSLPSVLADVKIKKYDFVQIFPHALGLIKNGEVVERKLRPVEAALKGVGINYIVRMPLSVNLRDHIYYSRHFKVAKAVVDVAIKLGAKIIVMQSGKTGRLDLEIEAIQQLADMAGKFGIKIALENTFSVKDTLYVVDNVDRENVGFALDVAHAFLSAQGDENKLLEDVKLGTEKTIILMIHDNFGKLTPQVEPEDALAYGVGDLHLLPGEGKIPFGKVLKLFGDVPLLLKVKDPDKFAKLPDKQTLIEILTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJN0</accession>
    <name>F0LJN0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">V-type ATP synthase subunit F</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">V-ATPase subunit F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpF</name>
        <name evidence="7" type="ordered locus">TERMP_01697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467970.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01697"/>
    <dbReference type="EnsemblBacteria" id="ADT84672">
        <property type="protein sequence ID" value="ADT84672"/>
        <property type="gene ID" value="TERMP_01697"/>
    </dbReference>
    <dbReference type="GeneID" id="26137102"/>
    <dbReference type="KEGG" id="tba:TERMP_01697"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1696"/>
    <dbReference type="eggNOG" id="arCOG04102">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135754_2_0_2"/>
    <dbReference type="OMA" id="QIPDKFG"/>
    <dbReference type="OrthoDB" id="113093at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00312">
        <property type="entry name" value="ATP_synth_F_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022944">
        <property type="entry name" value="ATPase_V1-cplx_fsu_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="102" mass="11607" checksum="E053B02B2C610D9B" modified="2011-05-03" version="1">MKIVLMGDRDTALGFKLAGVHEVYSFEETSLENERAKNKLKELIEREDVGIILITERLAQRIGIPDVAFPIILQIPDKFGSIFGEEQLREIVRKAIGVELKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJP0</accession>
    <name>F0LJP0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467980.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01707"/>
    <dbReference type="EnsemblBacteria" id="ADT84682">
        <property type="protein sequence ID" value="ADT84682"/>
        <property type="gene ID" value="TERMP_01707"/>
    </dbReference>
    <dbReference type="GeneID" id="10042023"/>
    <dbReference type="KEGG" id="tba:TERMP_01707"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1706"/>
    <dbReference type="eggNOG" id="arCOG00921">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1032961_0_0_2"/>
    <dbReference type="OMA" id="TRSEIHQ"/>
    <dbReference type="OrthoDB" id="85584at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022285">
        <property type="entry name" value="CHP03879_regulat_dom_put"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03879">
        <property type="entry name" value="near_KaiC_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="316" mass="37260" checksum="7D78A1DD9ACA1EE6" modified="2011-05-03" version="1">MTIEVPLNPLGRQEIHQLESILLFATLFRPEVIELIKDPAERLTWVDSLAVAAGAIAREKAGMTVSEIARELGRTEQTIRKHLRGESKAGELVRETYELIKQGKLDELIRTIEMIEKGGLKEVIAKEEYEKLMEEYEKLKLEYEKVKEELEKMKQTVELGSLEKAREEIEKLKKELEETKAALEKVKREKRELEKELSEAKVKLMELQAKRVDEDRIKELEEKLKAKEEEIEKLEKVVKELTLAKEELEKKVEEMEGLADELRKEKEELQKKVEELSRENEELKKKIDELEPYKIKFEELKEKIERLKEEIEKLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJP9</accession>
    <name>F0LJP9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467989.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84691">
        <property type="protein sequence ID" value="ADT84691"/>
        <property type="gene ID" value="TERMP_01716"/>
    </dbReference>
    <dbReference type="GeneID" id="26137082"/>
    <dbReference type="KEGG" id="tba:TERMP_01716"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1715"/>
    <dbReference type="eggNOG" id="arCOG05867">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186536_0_0_2"/>
    <dbReference type="OMA" id="MKIPFVI"/>
    <dbReference type="OrthoDB" id="121278at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010377">
        <property type="entry name" value="YabA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06156">
        <property type="entry name" value="YabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="86" mass="10527" checksum="F2157BB126932096" modified="2011-05-03" version="1">MLKEKICRDLYEEIERLERSIIELEDEIIELKAQLRAKTEEVTSLAIENQNLRYKLERLRRTHERLIEMLKKMNFPIIIINENEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJS0</accession>
    <name>F0LJS0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TrmB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468009.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01737"/>
    <dbReference type="EnsemblBacteria" id="ADT84712">
        <property type="protein sequence ID" value="ADT84712"/>
        <property type="gene ID" value="TERMP_01737"/>
    </dbReference>
    <dbReference type="GeneID" id="26137063"/>
    <dbReference type="KEGG" id="tba:TERMP_01737"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1736"/>
    <dbReference type="eggNOG" id="arCOG02243">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173773_0_0_2"/>
    <dbReference type="OMA" id="EHVLNLY"/>
    <dbReference type="OrthoDB" id="114229at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="110" mass="13057" checksum="75D63AA3101BFDD6" modified="2011-05-03" version="1">MSEIHEKLESLLRSLGIKKTEIRIYRLLLEKKVPMRITEIQKELGISERSVREHVLNLYRKGLLKRELIQKGWLGYVYTATSPAELLEKLKESIVKKINELEKELKEREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJX7</accession>
    <name>F0LJX7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfhydrogenase II subunit d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466812.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00537"/>
    <dbReference type="EnsemblBacteria" id="ADT83514">
        <property type="protein sequence ID" value="ADT83514"/>
        <property type="gene ID" value="TERMP_00537"/>
    </dbReference>
    <dbReference type="GeneID" id="10040855"/>
    <dbReference type="KEGG" id="tba:TERMP_00537"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.538"/>
    <dbReference type="eggNOG" id="arCOG02472">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053270_0_0_2"/>
    <dbReference type="OMA" id="GSWPEDI"/>
    <dbReference type="OrthoDB" id="44934at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="263" mass="29795" checksum="D13A7F57B6958F4A" modified="2011-05-03" version="1">MENRKIKIGFYALTSCYGCQLQFAMMDEILQLIDKAKIECWYMLSRDSSEEREVDIAFIEGSVSTKEEIELVKKIREKAKIVVAVGSCAVHGGVQSWGKEKELEQLWKTVYGDGKVKFEPKMAEPVEKFIKVDYKLYGCPPEKKDFLYALGTFLVGSWPEDIDYPVCVECRLRGNSCILIEKGEPCLGPVTVAGCDARCPAYGVACIGCRGAVGYDVAWFDSLAREFKKKGFTKEEILDRMRIFNAHNPKLEEMVNKIFEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK27</accession>
    <name>F0LK27_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01764</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01764"/>
    <dbReference type="EnsemblBacteria" id="ADT84739">
        <property type="protein sequence ID" value="ADT84739"/>
        <property type="gene ID" value="TERMP_01764"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01764"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1763"/>
    <dbReference type="eggNOG" id="arCOG01465">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1048153_0_0_2"/>
    <dbReference type="OMA" id="INAWRIL"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="38"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="271" mass="30430" checksum="5781AB20511DD16B" modified="2011-05-03" version="1">MMDINAMIKSIKVIKAFIFIQKEVFFSRRFDLLLQFISLGLNILFIGIFAKLITINANISQYGTPSYLDYLLIGSIIHNLVFLPKGSISSFVLGRIFPVLYNSPASLTAIFIGINAWRILWNLGLTLIITTIYVLFFGLTIHLNLGVVIVILSGVLLIFALDLFSAGFRIATKATQDPLNWFFNITAQLVSGLYFPPEALPKWLQPLSKIHPETYILQMGRLTMGGGYSLTQILPSLRNMLVITLIMLVLGYLMFSWGFNKARELGTLGHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK40</accession>
    <name>F0LK40_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468048.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01777"/>
    <dbReference type="EnsemblBacteria" id="ADT84752">
        <property type="protein sequence ID" value="ADT84752"/>
        <property type="gene ID" value="TERMP_01777"/>
    </dbReference>
    <dbReference type="GeneID" id="10042093"/>
    <dbReference type="KEGG" id="tba:TERMP_01777"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1776"/>
    <dbReference type="eggNOG" id="arCOG01182">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095575_1_0_2"/>
    <dbReference type="OMA" id="KNFTSAM"/>
    <dbReference type="OrthoDB" id="104998at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="216" mass="25195" checksum="6C7A3446582F4933" modified="2011-05-03" version="1">MIEHLISRNELRQFREFMKRKGIEELTFYSKGTTSLIFLGKFQGKRVIVKLERKDTPRKNFKREAEILKLLEGDDITPELIDYGIIGGKEYLVREFAEGKPLLYADLEKHHLIEIAKKTHKLDVLGIDHGQIQGGKHIIIGKSVWIIDFEKASTRRKPKNLTSAMAMLFLNENAISKRIREKFKINTEFLSELRKALKEYKENRDIERILSLLGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK48</accession>
    <name>F0LK48_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468056.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01785"/>
    <dbReference type="EnsemblBacteria" id="ADT84760">
        <property type="protein sequence ID" value="ADT84760"/>
        <property type="gene ID" value="TERMP_01785"/>
    </dbReference>
    <dbReference type="GeneID" id="26137298"/>
    <dbReference type="KEGG" id="tba:TERMP_01785"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1784"/>
    <dbReference type="eggNOG" id="arCOG04364">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108786_0_0_2"/>
    <dbReference type="OMA" id="RAAPICY"/>
    <dbReference type="OrthoDB" id="75704at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007501">
        <property type="entry name" value="DUF531"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04407">
        <property type="entry name" value="DUF531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006006">
        <property type="entry name" value="UCP006006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="180" mass="20346" checksum="556764DE642BC36B" modified="2011-05-03" version="1">MLTLALYNSYDPKKVHEAHLRAIARAAPICYAFDFHLALIGFPFNEKPLDLSEKISENTTIGEGGKYLLELAKKNKFHLLEFPKRGFPPQFGTIIATTRKPDEHKEISAIEVAKRALKGESFMLIVGLGRHGLPEEIFKLAEYHLDITDGKRISLETCTAIGSIPTKIRTLMEALKWKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKH1</accession>
    <name>F0LKH1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA topoisomerase 1</fullName>
            <ecNumber evidence="12">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">topA</name>
        <name evidence="15" type="ordered locus">TERMP_00652</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="12"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466927.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00652"/>
    <dbReference type="EnsemblBacteria" id="ADT83629">
        <property type="protein sequence ID" value="ADT83629"/>
        <property type="gene ID" value="TERMP_00652"/>
    </dbReference>
    <dbReference type="GeneID" id="10040970"/>
    <dbReference type="KEGG" id="tba:TERMP_00652"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.654"/>
    <dbReference type="eggNOG" id="arCOG01305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01527">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_5_2_2"/>
    <dbReference type="OMA" id="PECKYTR"/>
    <dbReference type="OrthoDB" id="14543at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005739">
        <property type="entry name" value="TopoI_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01057">
        <property type="entry name" value="topA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 12 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 12" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="14">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="12">
        <location>
            <begin position="197"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="590"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="12">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="12">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="12">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="12">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="12">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADT83629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="719" mass="82352" checksum="070B11FB26B72174" modified="2011-05-03" version="1">MVTLIIAEKPNVAKKIAYALAERKPIRKTLYGVPYYELSRDGKKIIVAPAVGHLYTLAPKTKTYGYPIFDIEWVPVYVAEKGKSYAKDYIKALRELAKRADEFIVACDYDTEGEVIGYTALKYACGVDPKKAKRMKFSALTKRDILKAWYNLEPTINFGMADAGIARHILDWYWGVNLSRALTHAIKRASGKWMILSTGRVQGPTLKFLVEREKEIANFKPTPYWVIKMTLEKNGKQYTATYEKERILDEEEAKRIVQEAKKGPAFVEKVEVKQQKRNPPHPFDLGTLQREAYSAFGYSPKKTLDIAQRLYEMGICSYPRTSSQKLPKNLNYKYIIQSLAKIPEYKPFAHELLGKPQLKPVEGQKDDPAHPAIYPTGELPKPGELTQEEKNIYDLIVRRFLAAFADPAVREIMKVIINSNNHHFILSGARTVKEGWLKIYGKYVSFDEVILPKFREGEPVKVIQIKREKKKTKPPARYSPASVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKKIRVTPLGMKVVEALEKNVPEIVSVELTREFEEKMDEIMKRKLSKDRVIEEARGQLIKILREFKAKELDIGKELMEKLLEREKNKKSKKKTAKELTAEEEEAIKNAVENHEKKSNNLIIVGKCPKCGGDLVVRYNRKTGKRFVGCSNWPSCDVTYPLLQRGKIIPTGKVCPECNAPVVKIKEGKKEYEVCLDMKCKKKMDKNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKH9</accession>
    <name>F0LKH9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-Acetyl-D-glucosamine ABC transport system, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468109.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01838"/>
    <dbReference type="EnsemblBacteria" id="ADT84813">
        <property type="protein sequence ID" value="ADT84813"/>
        <property type="gene ID" value="TERMP_01838"/>
    </dbReference>
    <dbReference type="GeneID" id="10042154"/>
    <dbReference type="KEGG" id="tba:TERMP_01838"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1837"/>
    <dbReference type="eggNOG" id="arCOG00157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_2"/>
    <dbReference type="OMA" id="LWYSVQS"/>
    <dbReference type="OrthoDB" id="42250at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="57"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="281" mass="31823" checksum="F989F436169CD87F" modified="2011-05-03" version="1">MKLRLPYLLLLPAVLYLVFFIGYPLVQALYLAFTQNGHFTLDNVRRTIGDPYFWQALKYTIALAVVIIPIQLFLALILAVVMNRTFKGKDLALYALIIPLTISDVAGGLIWYTMLTDAGFLNKLLLNLGLITQPIHFFGYEYRNMEFLAIVIEELWRATAIVFVIILAGLQMISKEYLEAAEVFGADYWTRMRKIVIPLLKPSIQSALIIRTLFAMQVFGVVWILAGRDIPVLAGEGFYQLTFIKDYGVASIYALTIAALSILLGAMYVKFLKAEYLEVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKK0</accession>
    <name>F0LKK0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0310 protein TERMP_01859</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0310 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468130.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01859"/>
    <dbReference type="EnsemblBacteria" id="ADT84834">
        <property type="protein sequence ID" value="ADT84834"/>
        <property type="gene ID" value="TERMP_01859"/>
    </dbReference>
    <dbReference type="GeneID" id="10042175"/>
    <dbReference type="KEGG" id="tba:TERMP_01859"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1858"/>
    <dbReference type="eggNOG" id="arCOG02727">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148445_0_0_2"/>
    <dbReference type="OMA" id="KPQYIRA"/>
    <dbReference type="OrthoDB" id="92589at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00771">
        <property type="entry name" value="UPF0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013989">
        <property type="entry name" value="Dev_and_cell_death_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022996">
        <property type="entry name" value="UPF0310"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51222">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="143" mass="16916" checksum="E91837F7EAD7FF82" modified="2011-05-03" version="1">MTYWLCITNRDNWEVIKKKNIWGVPKRHKNTIAKVKPGDKLVIYVKQERKDKQILEPKIVGIFEVMSEPYQDSTKIFKSPPHLNETYPLRVKIKAIKLGEVEFKPLIPKLNFITNKRKWSGHLMGKAMRELPEEDYKLIESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKK1</accession>
    <name>F0LKK1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NurA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468131.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01860"/>
    <dbReference type="EnsemblBacteria" id="ADT84835">
        <property type="protein sequence ID" value="ADT84835"/>
        <property type="gene ID" value="TERMP_01860"/>
    </dbReference>
    <dbReference type="GeneID" id="10042176"/>
    <dbReference type="KEGG" id="tba:TERMP_01860"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1859"/>
    <dbReference type="eggNOG" id="arCOG00367">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625034_0_0_2"/>
    <dbReference type="OMA" id="NIWLWKV"/>
    <dbReference type="OrthoDB" id="35597at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="57"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="436" mass="51008" checksum="AA2F483D2B423BCC" modified="2011-05-03" version="1">MSKFYDLFAKELRSKRDKWKKRYHSLPNTLEKFLRGKFNKFWKPVNLKDYERNPKEFNILAVDSSYQAESLKNGGIFYAVRALGISKDKEYRDLIVDFDYADGPVHNVTHFLQRKMEYLEIKVAADAIFDGFNGTILIDGSIYGRISHLIEEGPMSNDRGFFIEYYKEVMRLFKLAKENEVLLVGISKESRSRFFRDFLVKNLVSLDEIRGDVPLNEVFHLLSLALDQKRKAIKILDSLRRQYENIGLLDEVLKELLTPRPDYQLIDKFAQQPGYTIPLLLGPSARWLRGIEQIEKDPEGYIESHFPTLFSDPNFVSYAKVILKTIPDLPSIISMHVLPDVNDSPLRIDIPAFCLGNDVKLKEIGWPEPFTGTLDQIFEIIATGYGGLEFYNIWLWKVDREVKFHRHEFDELYFSKFKEAIGVEINARDYRRVRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKK8</accession>
    <name>F0LKK8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01867"/>
    <dbReference type="EnsemblBacteria" id="ADT84842">
        <property type="protein sequence ID" value="ADT84842"/>
        <property type="gene ID" value="TERMP_01867"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01867"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1866"/>
    <dbReference type="eggNOG" id="arCOG03890">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_350433_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="521"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="803" mass="93519" checksum="1372FB26996D7DEF" modified="2011-05-03" version="1">MKSSEPEEESFPLVEVDSEWNIIRINPEIAKSLFAKTVKTYYGLGKNYVAENLLHDEEKVEFLRRVYELFPYNYLAKSENGIPYYEYYSTAENIDADIVDHLQLIKIGEYHWEELDPHIAVRLITAHIRSSFGEFLKNKLSSRELKDVWIRLPKGRERVSLEFVKKFELGTLGYSIEDGEIWMALRRRSSASAVLLADFPPKVLEYVMIKLKKLAEEAVKQDYRKVRIYSETQPGSGTAAVIDVIIGHDNVIRFLEEHPKGAFHVKKRLEELGKSLDDVNYLLIGVYDNSISLKRALEDENCQYYFTEHNAYLVLTTEVQKELFGRIVDDWRGEIVEEYREKLNEITTSGKLFSQVSGIKGITVNIRENLLVRTLKGEITVKDVKDIMRDESIFLNLLPISEKILNETKRHNLRLLIFYPKKFDERIRKSIFLDQIERLRNGLLSNSFSSVDEVDLIPVSRDRSLDYHKTMLEAGLDKVRDYTLATIIFPEQYNKRDLELREFYNWLKKEFYDETKPLVFQGARVESVFGMYKRYAVPNIVLQMAAKLGVYPYSLETSSGYDYIIGIDYTYWHERDAVSVGGGAVVVSPSGLIEGIYPIAIPSKRESLDMKEILQEWFLKTVQNNPEIMKQGRVTVLISRDGMVPKYERNRIQEFLCEYSDELDMTIEAVEVRKRILTRIWSLDGPNTFYSPVKVGNYTYYMVNAHAGYPLRRKERKIYYSKPYLIGSLYRFQSGKVQPIHGSASRHLVESLIRLQKINYTTTKMDNVRLPLPIDVTHKLINFIRDVNMRVKRVGIPNSLFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKL0</accession>
    <name>F0LKL0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01869"/>
    <dbReference type="EnsemblBacteria" id="ADT84844">
        <property type="protein sequence ID" value="ADT84844"/>
        <property type="gene ID" value="TERMP_01869"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01869"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1868"/>
    <dbReference type="eggNOG" id="arCOG04793">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112310_0_0_2"/>
    <dbReference type="OMA" id="LYYVKTP"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="211" mass="24855" checksum="0CC3D334AB96509B" modified="2011-05-03" version="1">MNIMRSITQILLAEFGGKVITKEELEKFSTYLKVNDVDYLVNYLIQYGYIIRILRGLYYVKTPIEFSFKSSPTIYKLLSLGMNKITKNWYFGLFTALVLNGLTHEHYTTIFIINDKIARTKIIHINGTPVRIIKTKRELFNFGIIEKDDMKISDLEKTLLDFLYFGNYGTISKELALRIWREYKDSADWKKLKKYLEKYPESIAKVVDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKN9</accession>
    <name>F0LKN9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468169.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01898"/>
    <dbReference type="EnsemblBacteria" id="ADT84873">
        <property type="protein sequence ID" value="ADT84873"/>
        <property type="gene ID" value="TERMP_01898"/>
    </dbReference>
    <dbReference type="GeneID" id="10042214"/>
    <dbReference type="KEGG" id="tba:TERMP_01898"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1897"/>
    <dbReference type="eggNOG" id="arCOG05841">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808031_0_0_2"/>
    <dbReference type="OMA" id="FWIYPHE"/>
    <dbReference type="OrthoDB" id="91425at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="346" mass="40254" checksum="CAA62F5D5EA22DE8" modified="2011-05-03" version="1">MKRSLLSFFLVFWLFGAFLNASVTGEDYPLPGGDYNNIGIKASLYIDLNITLINTAPFPKFVIVNPYYNYIIYRENGEVLREIGNVSYITPALNTLNYLPGFWVNPYETLKVEVMVRDDNVIDLPLKEYKSAFPHSITIVYPNTTSVVYYVKTEKDVQNFFYGTVYPQLLLTPRYYFDVQTSFFGRDGDIKILKYDGEVTLVLQNIPNKYGLFRTLFAVGLPAVFENANHYGFTPEYTMRYSEYVSEFLPSFLGVKEEPKTQNVSKKEFNLYPLSNKLLSGKKIENIKQPKTKLESFDYPVWIVWLGSSPLEIKYHVSWNNDEKVNAIERQKEKALWFVLDRRNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKT2</accession>
    <name>F0LKT2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00684"/>
    <dbReference type="EnsemblBacteria" id="ADT83661">
        <property type="protein sequence ID" value="ADT83661"/>
        <property type="gene ID" value="TERMP_00684"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00684"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.685"/>
    <dbReference type="eggNOG" id="arCOG11751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2949483_0_0_2"/>
    <dbReference type="OrthoDB" id="131137at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="59" mass="6740" checksum="E2F0985183BD7B96" modified="2011-05-03" version="1">MGNDEGEGTIKNKRYILFPFFFGLAYGVGIFSVWWIFRLGRYLPDILDNLIVISANLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKT3</accession>
    <name>F0LKT3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)</fullName>
            <ecNumber evidence="2">2.5.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl diphosphate synthase</fullName>
            <shortName evidence="2">UDS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl pyrophosphate synthase</fullName>
            <shortName evidence="2">UPP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">uppS</name>
        <name evidence="3" type="ordered locus">TERMP_00685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27622"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:60388"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466960.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00685"/>
    <dbReference type="EnsemblBacteria" id="ADT83662">
        <property type="protein sequence ID" value="ADT83662"/>
        <property type="gene ID" value="TERMP_00685"/>
    </dbReference>
    <dbReference type="GeneID" id="26136086"/>
    <dbReference type="KEGG" id="tba:TERMP_00685"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.686"/>
    <dbReference type="eggNOG" id="arCOG01532">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_2_0_2"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="OrthoDB" id="50844at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="46"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="266" mass="31774" checksum="010346F3F3D1651B" modified="2011-05-03" version="1">MLIYRVISHIPHILFKPVYDLYERYLLEKVKANGRIPKHVAIIMDGNRRWARKLEKPPWYGHLFGSKKLEEILEWCRELNIKTLTVYAFSTENFKRSPEEVNALMNLFEQKFKELVHDERVHKYGIRVNVIGRRELLPENVRKAAEEAERATRKYSNYILNIALAYGGRSEIVDAIKRIVADIEDGNITKKDIDEELLKKYLYIPNMPDPDIVIRTGGEIRISNFLLYQIAYSELFFVDVYFPEFRKIDFLRIIREYQKRERRFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKU9</accession>
    <name>F0LKU9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">7,8 dihydropteroate synthase (Methanopterin)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466976.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00701"/>
    <dbReference type="EnsemblBacteria" id="ADT83678">
        <property type="protein sequence ID" value="ADT83678"/>
        <property type="gene ID" value="TERMP_00701"/>
    </dbReference>
    <dbReference type="GeneID" id="10041019"/>
    <dbReference type="KEGG" id="tba:TERMP_00701"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.702"/>
    <dbReference type="eggNOG" id="arCOG00503">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036012_0_0_2"/>
    <dbReference type="OMA" id="GHYDHTD"/>
    <dbReference type="OrthoDB" id="73329at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="273" mass="30397" checksum="4BCECB3CB954571A" modified="2011-05-03" version="1">MRITILFENHSGFKKGLFGGHGFSALVEHKRYKILVDTGVDGEILLRNMEALGIKPADIDYLFLTHGHYDHTEGLKALLGARRGKKLTIIAHPDIFAKRVALKPHLRDISLPFKREELEELGAEFILTRSPIQIVEGIYSSGEIERTTWDRTVGYRIESGKLVKDDVKDDIALILDLGDSVAVITGCGHSGVINIAMHSQKVMNKSIRALIGGFHLIGAKPELLEEITEKLKELKVEKIYAGHCTGFEAMGFFMTEFGRAFEPLYVGKVIELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL33</accession>
    <name>F0LL33_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468236.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01966"/>
    <dbReference type="EnsemblBacteria" id="ADT84940">
        <property type="protein sequence ID" value="ADT84940"/>
        <property type="gene ID" value="TERMP_01966"/>
    </dbReference>
    <dbReference type="GeneID" id="10042281"/>
    <dbReference type="KEGG" id="tba:TERMP_01966"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1964"/>
    <dbReference type="eggNOG" id="arCOG00014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_1_2"/>
    <dbReference type="OMA" id="NWRPTFW"/>
    <dbReference type="OrthoDB" id="40930at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="319" mass="35842" checksum="9B12B812B3B3A208" modified="2011-05-03" version="1">MIFSIGEILIDFIAKEEGSLKKVSTFEKHAGGAPANVTVGLVRLKTLAALISKVGADPFGEFLVEQLEKEGVNINYIRFDKEKHTGVVFVQLIGAKPEFILYDGVAYFNLKIDDIDFSFLEKASLLHFGSVLFAREPSRSTVFEVIKRAKGKIPISYDVNIRLDLWRGREEDMIKDIEKALSFADIVKIGDGELEFLENHGVDLESFNFKLMAVTKGERGSEIIHGEIKTEVPSYRVEPVDTTGAGDAFMAALLSALWHMDKLEHLELNEEELLRVGRFANLVAALSTLRRGAWSVPRAEELKEYKEAREVLIRTELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL73</accession>
    <name>F0LL73_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
            <shortName evidence="1">PGP</shortName>
            <shortName evidence="1">PGPase</shortName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dephosphorylation of 2-phosphoglycolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-phosphoglycolate + H2O = glycolate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58033"/>
            <dbReference type="EC" id="3.1.3.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal SPP-like hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467022.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00747"/>
    <dbReference type="EnsemblBacteria" id="ADT83724">
        <property type="protein sequence ID" value="ADT83724"/>
        <property type="gene ID" value="TERMP_00747"/>
    </dbReference>
    <dbReference type="GeneID" id="10042548"/>
    <dbReference type="KEGG" id="tba:TERMP_00747"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.749"/>
    <dbReference type="eggNOG" id="arCOG01213">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_2_0_2"/>
    <dbReference type="OMA" id="DTGYAYH"/>
    <dbReference type="OrthoDB" id="58398at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01419">
        <property type="entry name" value="GPH_hydrolase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006382">
        <property type="entry name" value="PGPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="233" mass="25459" checksum="EADE339868367295" modified="2011-05-03" version="1">MIKVISVDIDGTITYKDRRLHEEALRAIRLAESLGVKVMLVTGNTAGFAMGASILIGTTGPIIAEDGGVVADHNGNNRIYLGDMGECMILWSELKKRYPEAEMSHTMRYGERRAGLVLRRTISVGVVRELIKELGLNLVAVDSGYAIHVKQPWVNKGNGIKRACKILGIKPKEVAHIGDGENDLDAFEVVGYRVAVAQAPESLKRKADYITTKPYGEGGAEGILHVLKRFGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL81</accession>
    <name>F0LL81_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467030.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00755"/>
    <dbReference type="EnsemblBacteria" id="ADT83732">
        <property type="protein sequence ID" value="ADT83732"/>
        <property type="gene ID" value="TERMP_00755"/>
    </dbReference>
    <dbReference type="GeneID" id="26136207"/>
    <dbReference type="KEGG" id="tba:TERMP_00755"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.757"/>
    <dbReference type="eggNOG" id="arCOG05871">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2893452_0_0_2"/>
    <dbReference type="OMA" id="TELWWKL"/>
    <dbReference type="OrthoDB" id="126566at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="59" mass="7096" checksum="4AB55E9AA8C28852" modified="2011-05-03" version="1">MKEIFSKEGIFVEYKEKIVKLENGDMLIHTQESPTKLWWELKEVLKGKRVKVVVYEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLC2</accession>
    <name>F0LLC2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467071.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00796"/>
    <dbReference type="EnsemblBacteria" id="ADT83773">
        <property type="protein sequence ID" value="ADT83773"/>
        <property type="gene ID" value="TERMP_00796"/>
    </dbReference>
    <dbReference type="GeneID" id="10041114"/>
    <dbReference type="KEGG" id="tba:TERMP_00796"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.798"/>
    <dbReference type="eggNOG" id="arCOG04311">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039453_4_2_2"/>
    <dbReference type="OMA" id="YEKRDNI"/>
    <dbReference type="OrthoDB" id="96549at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="6">
        <location>
            <begin position="26"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="182" mass="21311" checksum="0B87724C846BD098" modified="2011-05-03" version="1">MLRLFIEAGKLKRLPRMGWLLRGVPNPESVADHSFRVAFITLFLAEDLRSRGIDVNVEKALKIALLHDLGESKITDLPLDAQRYVDKRKAEKKAVMELLLEVGEKSLEYFKLFEEYEEESSLEGRLVKFADKLEMTLQAYEYEVAGFGNLDEFWSALEYLKKSEFHKYFQELIEEVEKLRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLE1</accession>
    <name>F0LLE1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Replication factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468266.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01996"/>
    <dbReference type="EnsemblBacteria" id="ADT84970">
        <property type="protein sequence ID" value="ADT84970"/>
        <property type="gene ID" value="TERMP_01996"/>
    </dbReference>
    <dbReference type="GeneID" id="10042311"/>
    <dbReference type="KEGG" id="tba:TERMP_01996"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1993"/>
    <dbReference type="eggNOG" id="arCOG01510">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_777604_0_0_2"/>
    <dbReference type="OMA" id="WICPEHG"/>
    <dbReference type="OrthoDB" id="32957at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OB" evidence="3">
        <location>
            <begin position="73"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Rep_fac-A_C" evidence="4">
        <location>
            <begin position="195"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="355" mass="40422" checksum="A6C67050210B9147" modified="2011-05-03" version="1">MTVLTKEQIIELIRRQKKLSLNEIEEQIREIAQRDKISEHAAALLLAEQLGVNLEETAPLMYIADLVSGMRDVNIVGRILRKYGIREYTKRDGTKGQVASILIYDSTGKARVVLWDGKVGEYYNKLQVGDVIKVIDANVRESLAGIPELHVNFRSRIIVNPEDPRVEEIPPLEEVRTYSYSRRKIAELMGGEKFVELRGTIAKLYRVIVYDACPECRRKVDYDPGMNVWICPEHGEVKPLKMTVIDFGIDDSTGYIRATLFGEDAAELLGADPEEISEKLKELTEMGMTVKEAGRKLAEEEFYPLLGREIVIRGNVVEDRFLGMLLKASSWEDVDYRGEIERIKRELKGTLGEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLI4</accession>
    <name>F0LLI4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="4 9">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">purD</name>
        <name evidence="12" type="ordered locus">TERMP_02039</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="4 9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468309.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02039"/>
    <dbReference type="EnsemblBacteria" id="ADT85013">
        <property type="protein sequence ID" value="ADT85013"/>
        <property type="gene ID" value="TERMP_02039"/>
    </dbReference>
    <dbReference type="GeneID" id="10042354"/>
    <dbReference type="KEGG" id="tba:TERMP_02039"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2036"/>
    <dbReference type="eggNOG" id="arCOG04415">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027420_3_0_2"/>
    <dbReference type="OMA" id="KATVCKY"/>
    <dbReference type="OrthoDB" id="58022at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="108"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT85013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="432" mass="47870" checksum="A866FE90BE6BDD3D" modified="2011-05-03" version="1">MKVLLVGAGGRESAIAEALVKSGTKLYVVAKHVNPGIKRLAEWYGLAKETDVKKILDFALKWNVDLAFIGPEAPLEKGIVNLLEENGIPTVGPSKEAARLETNKAFARALMEKHKIPGRKLFKVFDDAKEMRAWVDDFGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEHLIKKDGKVLIEERTDGVEFTFQVFTDGKRVIPMPLVQDYPHAYEGDVGPITGGMGSYSCKDHLLPFITKEDYEKALNTLEKTIRAMRKEGIPYKGILYGQFMLAKDEPKIIEYNARFGDPEAMNVLPVLETPLLEIAEGIVDGNLKKAEFEKKAAVVKYIAPKGYPENPVRGVQIQVDEAKILESGAKIYYASIDENLTLLGSRALAVVGIADSLEEAEKIASAGIKHVKGEIFYRRDVGTRESVEKRIKIMRELRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLL0</accession>
    <name>F0LLL0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00810"/>
    <dbReference type="EnsemblBacteria" id="ADT83787">
        <property type="protein sequence ID" value="ADT83787"/>
        <property type="gene ID" value="TERMP_00810"/>
    </dbReference>
    <dbReference type="GeneID" id="10041128"/>
    <dbReference type="KEGG" id="tba:TERMP_00810"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.812"/>
    <dbReference type="eggNOG" id="arCOG01290">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015525_2_2_2"/>
    <dbReference type="OMA" id="CYARLYT"/>
    <dbReference type="OrthoDB" id="37613at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="27"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="265" mass="31030" checksum="638B6DEAEC476E14" modified="2011-05-03" version="1">MRIVKTKAKSIYTKSRIPGVDYVINQYVGCQFACKYCYAKFICKWKPYGEWGSWIEVKVNAPELARKYVEGGVVMSSISDPYQPIEAKVKLTRRVLQNMSKRTNLSILTKSPLVTRDVDIFRQFKNIEVGLTVNSFEGKEKKLFEPLTPIQRARINALKLLHEEGIKTYAFISPIIPGITDVEAIVRETKSYADYFFFEVLNLRASGKEFQQILRDNYPESYETMVNDEKFWRFIKQLKEEIKRLNVKTEGIEIHKRGWEFIQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLN5</accession>
    <name>F0LLN5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00835"/>
    <dbReference type="EnsemblBacteria" id="ADT83812">
        <property type="protein sequence ID" value="ADT83812"/>
        <property type="gene ID" value="TERMP_00835"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00835"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.838"/>
    <dbReference type="HOGENOM" id="CLU_3283044_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="40" mass="4430" checksum="080FBE0C9FDBDE2A" modified="2011-05-03" version="1">MADGEVIVLLFEIHRLANTPRITTAKTTPATILFIKITYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLP9</accession>
    <name>F0LLP9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467124.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83826">
        <property type="protein sequence ID" value="ADT83826"/>
        <property type="gene ID" value="TERMP_00849"/>
    </dbReference>
    <dbReference type="GeneID" id="10041167"/>
    <dbReference type="KEGG" id="tba:TERMP_00849"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.852"/>
    <dbReference type="eggNOG" id="arCOG10269">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1438180_0_0_2"/>
    <dbReference type="OMA" id="REFHIAW"/>
    <dbReference type="OrthoDB" id="102226at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="188" mass="21550" checksum="8532BA39C12EB0B0" modified="2011-05-03" version="1">MQKNKMIVVLFIMLIVLPLVAADDDYESEEAQFGGLAEVGFAVITAGIVLYSVVKRTPFIEYKKGHFFIAVNPEMPFLRLRAPLSLLDIHHLLVILGSLMTLPHFISCQDYSTPAGLTGLLLGFILLIENISGFYGRYLHAKVEKLRREISNPYLKEALKKFRRWREFHIAWTVVMYIILVLHVIFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLQ6</accession>
    <name>F0LLQ6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase chain B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467131.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00856"/>
    <dbReference type="EnsemblBacteria" id="ADT83833">
        <property type="protein sequence ID" value="ADT83833"/>
        <property type="gene ID" value="TERMP_00856"/>
    </dbReference>
    <dbReference type="GeneID" id="10041174"/>
    <dbReference type="KEGG" id="tba:TERMP_00856"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.859"/>
    <dbReference type="eggNOG" id="arCOG01554">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_2"/>
    <dbReference type="OMA" id="AGWVRKS"/>
    <dbReference type="OrthoDB" id="100307at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="1">
        <location>
            <begin position="25"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="190" mass="22473" checksum="30F0FFE1BA850F59" modified="2011-05-03" version="1">MVDWRLFEPLFEFARKRSLWIVAFCTGCGGIEMPPLMTSRYDLERFGMMPNPAPRMADLFLITGYVTPKTLKRIIITYEMQPDPKYVMAHGSCPLNGGIYWDAYNAIKHLDKYIPVDVYIAGCMPRPEAVMDGIKKIMEMIENGTADGWKRYKENYEYYKKNQDELFGEGWREKEARKWIPWLMDKRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLR7</accession>
    <name>F0LLR7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00867"/>
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    <dbReference type="eggNOG" id="arCOG00951">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR040088">
        <property type="entry name" value="MJ0103-like"/>
    </dbReference>
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        <property type="entry name" value="rSAM"/>
    </dbReference>
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        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="115"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="5">
        <location>
            <begin position="363"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="424" mass="48431" checksum="621AEB657B98A742" modified="2011-05-03" version="1">MANMIKIKLPHSYFEDLGESVRLVWRNTLYADFEKKILAKVIKKKYRVRPEITAEKGYLIIDNIDDPDVEKFVEFFISNNLGAFLKSRYTRREVIYIHEGMNVPLLGYNAFGLIDRGTNLIQVRGSSGCNLSCIFCSVDEGPYSRTRRIDYVVDIDYLMKWFDEVARFKGKGLEAHLDGQGEPLLYPFIVELVQALKEHPNVDVVSMQSNGVLLNDKLVEELAEAGLDRINLSVHSLDPEKAKMLMGMKNYDLNHVLEMAEALVNAGIDVLLAPVIIFGVNDNEAEAFIEFARKIGAGKRWPALGFQNYMPYKFGRNPAIARLVPFKKFYEWLRELEKKTGMKPLVLRPEHFGMHRRKFIPLAFRTGEVVKAEVVLPGRIEGEMLAVARNRLIEVINTNARVGDKIRVKIVRTRHGIYVGTPVK</sequence>
</entry>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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    <dbReference type="EnsemblBacteria" id="ADT83847">
        <property type="protein sequence ID" value="ADT83847"/>
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    </dbReference>
    <dbReference type="GeneID" id="10041188"/>
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    <dbReference type="PATRIC" id="fig|391623.17.peg.873"/>
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    <dbReference type="OMA" id="NSSYCNG"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007152">
        <property type="entry name" value="DUF354"/>
    </dbReference>
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        <property type="entry name" value="PTHR39662"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005357">
        <property type="entry name" value="UCP005357"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="359" mass="40254" checksum="833454642F44018D" modified="2011-05-03" version="1">MKIWIDIVNSPHAHFFKGIIKELEKRGHEILVTTREFDGLTDILDMLGIDYYVVGKHGGSTLEGKLLASAERQYKLAKLIIEEKPDLCAHKNSPEAPRIAYGLGIPTIGFVDNDTSIPVNKLMLPFTNRVIYPKAIDAYDLIRCGADANSLRPINGFPEIAHLYGFKPNTAPLKELGIEKYSYIVMRTEPIKANYFNGDAEKSILEDIIPLLPDLPIVLFPRTEEQAKRFKRFDNVIIPDHVTDSLSLLYYAKLMIGAGGTMNREALALGTPTISTYPGKLLAVTKWLISLGIKYHSTNPIEVASKAWEMVRKNGTYRNYIRSVVSTLENPVEVMIEEIETYEELGTFPPLQNSKAVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLW2</accession>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02087"/>
    <dbReference type="EnsemblBacteria" id="ADT85061">
        <property type="protein sequence ID" value="ADT85061"/>
        <property type="gene ID" value="TERMP_02087"/>
    </dbReference>
    <dbReference type="GeneID" id="10042402"/>
    <dbReference type="KEGG" id="tba:TERMP_02087"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2084"/>
    <dbReference type="eggNOG" id="arCOG06140">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2839549_0_0_2"/>
    <dbReference type="OMA" id="ADIYDEW"/>
    <dbReference type="OrthoDB" id="126032at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="65" mass="7468" checksum="803D547BE04E82FC" modified="2011-05-03" version="1">MGKVVITLNVPDGMEDVVKSILEREAKLIMKRLSRADFKNTFGILRGKKKSVENIEADIYDEWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLZ2</accession>
    <name>F0LLZ2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85091.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="10042432"/>
    <dbReference type="KEGG" id="tba:TERMP_02117"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="80" mass="9030" checksum="4B50DB2A14FC8EED" modified="2011-05-03" version="1">MDVEDYILLFLSFWILISALATKTVDVFLTLTLIGLLITLEVGGPFLSKEQKENMKPLIELLLIIFAIIVMKKVYEVLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM15</accession>
    <name>F0LM15_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
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            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468410.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02140"/>
    <dbReference type="EnsemblBacteria" id="ADT85114">
        <property type="protein sequence ID" value="ADT85114"/>
        <property type="gene ID" value="TERMP_02140"/>
    </dbReference>
    <dbReference type="GeneID" id="10042455"/>
    <dbReference type="KEGG" id="tba:TERMP_02140"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2137"/>
    <dbReference type="eggNOG" id="arCOG05803">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145830_0_0_2"/>
    <dbReference type="OMA" id="HTEWVSW"/>
    <dbReference type="OrthoDB" id="111093at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="137" mass="16365" checksum="19E203F39C492677" modified="2011-05-03" version="1">MIKKEEILKKAYQLGYFVGFYGHTEWVRWISKEKEQIYSTAKSLGIYEEVRKAYALGKDDGTKKREELLQKGLSIEPPEDQEEIKFILEDFMKEEKTEKHYLHFLKLSKITAKPEFLTNTELTKKPKFLKLPRFIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM17</accession>
    <name>F0LM17_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468412.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02142"/>
    <dbReference type="EnsemblBacteria" id="ADT85116">
        <property type="protein sequence ID" value="ADT85116"/>
        <property type="gene ID" value="TERMP_02142"/>
    </dbReference>
    <dbReference type="GeneID" id="10042457"/>
    <dbReference type="KEGG" id="tba:TERMP_02142"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2139"/>
    <dbReference type="eggNOG" id="arCOG05842">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2366378_0_0_2"/>
    <dbReference type="OMA" id="MNYVPLI"/>
    <dbReference type="OrthoDB" id="122307at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="94" mass="10824" checksum="5E9E2B69D67ABB52" modified="2011-05-03" version="1">MSELLEYLDMLASKMRYAEELYGIPINCVPIIIDKEIIVYDRRDGSIKRLSDKKRISKKELKKLEKEIIKNIESGKVDLYLTLTFGEDVGLGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM18</accession>
    <name>F0LM18_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468413.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02143"/>
    <dbReference type="EnsemblBacteria" id="ADT85117">
        <property type="protein sequence ID" value="ADT85117"/>
        <property type="gene ID" value="TERMP_02143"/>
    </dbReference>
    <dbReference type="GeneID" id="10042458"/>
    <dbReference type="KEGG" id="tba:TERMP_02143"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2140"/>
    <dbReference type="eggNOG" id="arCOG00535">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_5_2_2"/>
    <dbReference type="OMA" id="KVSKNHP"/>
    <dbReference type="OrthoDB" id="122080at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="73" mass="8518" checksum="D5CF2AE1783E35FD" modified="2011-05-03" version="1">MKVKIRLYGELALKFSPEFEVEIEENLTVGDLLKKLKISDQEYHILVNEKKVSKDHKLKENDYIKLLPVVYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM24</accession>
    <name>F0LM24_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homing endonuclease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00895"/>
    <dbReference type="EnsemblBacteria" id="ADT83871">
        <property type="protein sequence ID" value="ADT83871"/>
        <property type="gene ID" value="TERMP_00895"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00895"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.896"/>
    <dbReference type="eggNOG" id="arCOG03156">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1363711_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="1">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="200" mass="22779" checksum="66744A0DB36F349B" modified="2011-05-03" version="1">MDKGFAETFLNGVNSTFGFERDTSRVNRWYVEASNKELFMFLNKSIDKLIETAGNYPADFLRGFFDSEGYPIIEAKNRFRVMVGVANSNLETIGAVKDMLAQLGISSTIRRSNLIGQEVVIRGIKYTSNVDMYTLTVSRKADVKRFAELVGFSSSTKMKKLQFAIQLMDLPDDKAISKWHRLYYKTPRGYKLKNSTGKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM35</accession>
    <name>F0LM35_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prok-JAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467180.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00906"/>
    <dbReference type="EnsemblBacteria" id="ADT83882">
        <property type="protein sequence ID" value="ADT83882"/>
        <property type="gene ID" value="TERMP_00906"/>
    </dbReference>
    <dbReference type="GeneID" id="26136351"/>
    <dbReference type="KEGG" id="tba:TERMP_00906"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.907"/>
    <dbReference type="eggNOG" id="arCOG01139">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116578_1_0_2"/>
    <dbReference type="OMA" id="HPNEYMG"/>
    <dbReference type="OrthoDB" id="118690at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prok-JAB" evidence="6">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="122" mass="14268" checksum="8E537A2DE92A97AF" modified="2011-05-03" version="1">MKVKIRRELFEYLLQLARDFYPNEFGGFLREIDGIFEEVLIIPKGHFGKRSIFFDPWLLPHDENIKGTVHSHPTPYGRPSKADLHFFSKFGGIHIIIAYPFEKWSVKAYTSDGKEVKIEIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM39</accession>
    <name>F0LM39_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Archaeal Lon protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">TERMP_00910</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S16 family. Archaeal LonB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467184.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00910"/>
    <dbReference type="MEROPS" id="S16.A11"/>
    <dbReference type="EnsemblBacteria" id="ADT83886">
        <property type="protein sequence ID" value="ADT83886"/>
        <property type="gene ID" value="TERMP_00910"/>
    </dbReference>
    <dbReference type="GeneID" id="10041227"/>
    <dbReference type="KEGG" id="tba:TERMP_00910"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.911"/>
    <dbReference type="eggNOG" id="arCOG02160">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392630_0_0_2"/>
    <dbReference type="OMA" id="GLYFWNL"/>
    <dbReference type="OrthoDB" id="7657at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041699">
        <property type="entry name" value="AAA_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004663">
        <property type="entry name" value="Lon_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13654">
        <property type="entry name" value="AAA_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00764">
        <property type="entry name" value="lon_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="13">
        <location>
            <begin position="188"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="14">
        <location>
            <begin position="437"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADT83886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="639" mass="70334" checksum="DBCEA89A6CEDEDD8" modified="2011-05-03" version="1">MGEGEKKEDRIEPSQGYGERLDLGIEFQTTEEIKVPDKLIDQVIGQEHAVEVIKTAARQKRHVLLIGEPGTGKSMLGQAMAELLPTEELEDILVFPNPEDENMPRIKTVPACQGKRIVERYREKAKSQESIKSYLLLFVLFVVMIAVLMDPSPQTLLMGLFVVIISIMAISNLRLKNQVLVPKLLVDNCGKRKAPFVDATGAHAGALLGDVRHDPFQSGGLGTPAHERVEPGMIHRAHKGVLFIDEIATLSIKMQQSLLTAMQEKKFPITGQSELSSGAMVRTEPVPCDFVLVAAGNLDTVEKMHPALRSRIRGYGYEIYMRTTMPDTLENRKKLVQFVAQEVKKDGKIPHFTKDAVEEIVREAQKRAGRKGHLTLRLRDLGGVVRAAGDIAIREGAKYVTREHVLRALQLAKPLEKQLADWYIERKKEYQVIKVEGGEIGRVNGLAVIGEQSGIVLPIEAVVAPAASREEGKIIVTGKLGEIAKEAVQNVSAIIKRYKGEDISNYDIHVQFLQTYEGVEGDSASISVATAVISALEEVPVKQSVAMTGSLSVRGEVLPVGGVTPKIEAAIEAGIKKVIIPKANEKDVFLSPDKAEKIEIIPVETIDQVLEIALEESEKKEKLIKRIKEALPLYPSTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM44</accession>
    <name>F0LM44_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Single-stranded exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467189.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00915"/>
    <dbReference type="EnsemblBacteria" id="ADT83891">
        <property type="protein sequence ID" value="ADT83891"/>
        <property type="gene ID" value="TERMP_00915"/>
    </dbReference>
    <dbReference type="GeneID" id="10041232"/>
    <dbReference type="KEGG" id="tba:TERMP_00915"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.916"/>
    <dbReference type="eggNOG" id="arCOG00367">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665023_0_0_2"/>
    <dbReference type="OMA" id="LVYTNAM"/>
    <dbReference type="OrthoDB" id="45596at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016738">
        <property type="entry name" value="NurA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018871">
        <property type="entry name" value="UCP018871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="43"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="440" mass="50859" checksum="4D51A4B6BE661BAE" modified="2011-05-03" version="1">MYRLISKDQADKILNMLISELREAENALSGKIEWKPLPEKKESKVYAVDGSQGKARLSGTIIYTVASFAFGNGKSARLVYTNAMIYNHGISDQIIRLQMETLENKLGALVGTEEHMILMDGTLTGSLTRPPVYPESVRGITTVMETLGDKMLEDLIKDFIDRLDYHYYDLSRRLKEKRELYSGVILADDVIGDYSEFYKAMEGKEVVNYDGALKKLRDALRTNMPQDEIIKIAERLEEYTEPKTLTLEDAKNTIHVVLGYLEYLYSLEKLLQKELIYIAKSFYNRKITSKFGISAVDVPFLDAYLLKVYGEELPGYYVIYDPEKTEEKKRIAHRLPRVLRKYFPTVQEFIEKGVPSAYIRTMKGGVIYLLQSNRTIDDELIGKLLWHESSGYIRPLQRAHEGVKIEQRMFKAELEALMNYLKRKNKELRVFIKYGRSPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM83</accession>
    <name>F0LM83_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dolichol-phosphate mannose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467228.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00954"/>
    <dbReference type="EnsemblBacteria" id="ADT83930">
        <property type="protein sequence ID" value="ADT83930"/>
        <property type="gene ID" value="TERMP_00954"/>
    </dbReference>
    <dbReference type="GeneID" id="10041271"/>
    <dbReference type="KEGG" id="tba:TERMP_00954"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.957"/>
    <dbReference type="eggNOG" id="arCOG00896">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_622049_0_0_2"/>
    <dbReference type="OMA" id="GDLTPMY"/>
    <dbReference type="OrthoDB" id="17570at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="221"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="440" mass="49834" checksum="D0AC429114D959C1" modified="2011-05-03" version="1">MDIRLAIFDLDGTLIGAPMTFTEIKEKLREKLLEIGIPQEIIGDLTPMYENLFRIAEETGKDVNGLKKLLEELEVKRVYESFLFEGTKEILEFLKSQGIKLAIMTRNCRDATLKALEMHGIKDYFELILTRDDVSWREVKPNEMHIKRILEHFKVPSTKTVVIGDHGYDIIPAKKVGALSILITEHESGRMSFSIEEKADFEVPTMRELLSLFRRILNAYVVVPAYNEEHTIGKVLDDLLRYFKSEHIIVVNDGSRDKTEEIAKNRGVRILTHLVNRGLGGALGTGIRYALFKGAELIITFDADGQHLVEDALRVMKPVAEGKADLAIGSRLRGDISQMPFIKRFGNFVLDAITAVFAGRYVSDSQSGLRCFNRKCASKIKITCDRYAVSSEIIIEASKNKCRIVEVPIRAIYTEYAMKKGTNVFEGIKIALNLLFDKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMA0</accession>
    <name>F0LMA0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02149"/>
    <dbReference type="EnsemblBacteria" id="ADT85123">
        <property type="protein sequence ID" value="ADT85123"/>
        <property type="gene ID" value="TERMP_02149"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02149"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2146"/>
    <dbReference type="eggNOG" id="arCOG03805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063611_0_0_2"/>
    <dbReference type="OMA" id="EWFAPIG"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008553">
        <property type="entry name" value="DUF835"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05763">
        <property type="entry name" value="DUF835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DUF835" evidence="2">
        <location>
            <begin position="225"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="353" mass="40687" checksum="3AF324F90F357032" modified="2011-05-03" version="1">MGRGLSLVIKLIAALYLLYIARTRDRKSALIWGLAWLSAALSILFDIAGVNYLNSLFEALFASLLFCGVLMIINEEAFYFFTPGFYYVASVPFIITLYLIGIMHFGERSEWMMTIGVPYGLSGFYILLSGVLILPFSRVYRKKATFLAISLILYGAHEMDYPILRPVSWFAPIGFLLGAIFTFMVSYSVIQFVRTERFQEFPRRRKYEKSEGEIETGVLIIGEEKYREIRETLQNTKVLAFLRDLSNVPGRWEVYFITHITGKDFKTISPTNLAKMVELVNRYLRSMAETEQRGIIVIDCLEYLIMYNSFESIVKFLSLLRDFVLMYGGTLVLVTNPSVWSEKEWALLKRLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMP4</accession>
    <name>F0LMP4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467321.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01047"/>
    <dbReference type="EnsemblBacteria" id="ADT84023">
        <property type="protein sequence ID" value="ADT84023"/>
        <property type="gene ID" value="TERMP_01047"/>
    </dbReference>
    <dbReference type="GeneID" id="26136499"/>
    <dbReference type="KEGG" id="tba:TERMP_01047"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1050"/>
    <dbReference type="eggNOG" id="arCOG01195">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_3_3_2"/>
    <dbReference type="OMA" id="VITDREP"/>
    <dbReference type="OrthoDB" id="108083at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="101" mass="11943" checksum="038B64C11A59C144" modified="2011-05-03" version="1">MLEEVKRIILEESSKLGITVENVILFGSRARGNYRKDSDWDILIIVKEPLSRTEYRELWRRIYEKVELPADILIVSKKDFEKLKGLKGYVYYYASKEGVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMQ7</accession>
    <name>F0LMQ7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01060"/>
    <dbReference type="EnsemblBacteria" id="ADT84036">
        <property type="protein sequence ID" value="ADT84036"/>
        <property type="gene ID" value="TERMP_01060"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01060"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1063"/>
    <dbReference type="eggNOG" id="arCOG00304">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061999_1_1_2"/>
    <dbReference type="OMA" id="MMDLHTH"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="221" mass="24901" checksum="326790E0CCDB61E6" modified="2011-05-03" version="1">MKVFRMIDIHTHTQYSDGIGMIGDNVAEAEKKGLKLVGISDHVHYFTPKRLNTYISEIRQIKKDSEITVLAGIEANILATGVDITTEMAKKLDYVIASAHVWLDPGGIDAYLDLIKIAIQDENVDIIGHFGNVFPYIGYPSYEEYLEIVELAEEYGKAFEISSRYRVPELDFIKLCIRRGIKLTFASDAHIPSDVGAIRWSEKVFKKAGGTREDLLFSELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMR2</accession>
    <name>F0LMR2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467339.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01065"/>
    <dbReference type="EnsemblBacteria" id="ADT84041">
        <property type="protein sequence ID" value="ADT84041"/>
        <property type="gene ID" value="TERMP_01065"/>
    </dbReference>
    <dbReference type="GeneID" id="10041382"/>
    <dbReference type="KEGG" id="tba:TERMP_01065"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1068"/>
    <dbReference type="eggNOG" id="arCOG01225">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_3_0_2"/>
    <dbReference type="OMA" id="METFLFH"/>
    <dbReference type="OrthoDB" id="86220at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="PTHR21231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="PTHR21231:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="247" mass="28144" checksum="248DD8E3B9A466B1" modified="2011-05-03" version="1">MILTFVGTAGSGKTTITHTFGKYLEKEGYTVGYVNLDTGVKKLPYKPNIDVRETVTVEEIMKEGYGPNGAIVESYDRLMPHIERYITKILELERGKDYVLIDTPGQIETFLFHEFGVRLMENLPAPLVVYLFSPEVLRKPHDYCFVRFFALMIDLRLGSTTVPALNKVDLVDNLERHKQYLEDMEYLTSRLKLDSSTQGLLAYKLCTFLPEVSPPVRILYLSAKTGEGFDDLETIAYEHYCTCGDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMT8</accession>
    <name>F0LMT8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L31e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl31e</name>
        <name evidence="7" type="ordered locus">TERMP_01091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ribosomal protein L31e family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01091"/>
    <dbReference type="EnsemblBacteria" id="ADT84067">
        <property type="protein sequence ID" value="ADT84067"/>
        <property type="gene ID" value="TERMP_01091"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01091"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1094"/>
    <dbReference type="eggNOG" id="arCOG04473">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112570_3_2_2"/>
    <dbReference type="OMA" id="KEFATHH"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00410">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_L31e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_L31e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_L31e_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="PTHR10956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="SSF54575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="125" mass="14337" checksum="90C965E8902D1C24" modified="2011-05-03" version="1">MAIKVGDEVIFTVPIRKIKKIVPRWKRAPRAAKFVREFIARHAKAEEVVIAPEVNEKIWERGIEKPPSKLRVKVKVVEEEVEGKGKVRVAYVELPPGAKKTVKEEKKTEEKKEEEKEPEAQATES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMX0</accession>
    <name>F0LMX0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">infB</name>
        <name evidence="14" type="ordered locus">TERMP_01123</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9 10">Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01123"/>
    <dbReference type="EnsemblBacteria" id="ADT84099">
        <property type="protein sequence ID" value="ADT84099"/>
        <property type="gene ID" value="TERMP_01123"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01123"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1126"/>
    <dbReference type="eggNOG" id="arCOG01560">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03151">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002656_3_4_2"/>
    <dbReference type="OMA" id="DHGKCLL"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_A">
        <property type="entry name" value="IF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004544">
        <property type="entry name" value="TF_aIF-2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00491">
        <property type="entry name" value="aIF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 9 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="12">
        <location>
            <begin position="231"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="11">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="551"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="624"/>
            <end position="628"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="678"/>
            <end position="681"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADT84099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1144" mass="130312" checksum="C521719086C7F69B" modified="2011-05-03" version="1">MKRIRQPIIAVLGHVDHGKCLLPDEKIIVPELGEVTLKELFELGGEVIAKDWEKEIRKLNIEVHVVSQDGTIRRAKSPYIWRLKHRGKILRVKLKNWHSISVTPEHPFLTNKGWKRADQLKPGDYVAVPKRIEGNESYERFMEFVYSKILTKELIVKIGEDKLEKIRKHFREYKIYKVQKNVFRKEDIEKLNLNDSIEKIAFTPRVHRSGKPLYYLEMPKSMGEWKAVFYFAGVMFGDGSQEKIANNDEEVFERLKGLESLGVELVRVKRRTSYEIELRKAKNALLRLIKVLFEYPEEKKAHNIKVPKVLFIAPKGLVAEFVRGYFDADAYVSLKDARIEVTSASKEFIEKLTLVLLRFGILSKIYENKGYWTLIISGRRNLIEFRRHIGFTVRAKAERLDEIIKKSKKSELYPIQEELKRLRLLFGFTKSELNSEVSYYSKYESSELPSYEILKKILAAIRRGSKNLDTKLSTLEGSKIDHNYIKAFEADGLIKNGKLTELGKELVEVWKNKEFDSKDVDYIENIIENLAFIPVESVEEIEYDGYVYDLTTETHNFIANGILVHNTTLLDKIRKTNVAAKEAGGITQHIGATEVPIDVVKQIAGPLLKLWKGEIKLPGLLFIDTPGHEAFTSLRARGGSLADLAILIVDINEGFQPQTIESIEILRRYKTPFIVAANKIDRIKGWKIQEWEPFLVNIKKQDQRAVQELETKLWELIGKFYEMGFQANRFDRVQDFTRELAIVPISAKYGIGVPELLVLIAGLSQKYLEKKLKIEVEGPARGTILEVREEPGLGTTIDVIIYDGTLHKDDIIVVGGKDKAIVTKIRALLKPKPLDEIRDPRFRFDQVDEVVAAAGVKIAAPDLEEALAGSPVIACRSEEEIEKARQEILNQIKSVVISTDKVGVIVKADTLGSLEALSKELQEKNIPIRKADVGNISKTDVMEALSVKEEKPLYGVVLGFNVKVNEDAEEIAKAKGVPIFVGNIIYKIIEDYEAWVKAEEEKKKKELLAKTTFPGVIRLFPDERYVFRRSHPAIVGVEVLEGRIKPGYTLIKQNGQKVGTIKSIKSKNDFLQEAKKGEAVAIAIDGPIVGRHIHPGEILYVDLSRDDAIRLVKELRDMLDETDIKALKMIAKVKAREDPFWAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMY0</accession>
    <name>F0LMY0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467407.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01133"/>
    <dbReference type="EnsemblBacteria" id="ADT84109">
        <property type="protein sequence ID" value="ADT84109"/>
        <property type="gene ID" value="TERMP_01133"/>
    </dbReference>
    <dbReference type="GeneID" id="10041450"/>
    <dbReference type="KEGG" id="tba:TERMP_01133"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1136"/>
    <dbReference type="eggNOG" id="arCOG00157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_2"/>
    <dbReference type="OMA" id="VSFGMIV"/>
    <dbReference type="OrthoDB" id="42276at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="77"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="315" mass="35951" checksum="A7BCD1EB8B932213" modified="2011-05-03" version="1">MNKINKEKFTALSFFLSPMLLMVVLFYLIPLIMTVYISFTQMRNWNVERYLKDFVGLYNYERLFYMFQHDPTFKAVILTTVVFVGITLIINVFGGLALALATFFISEKPASSFRLLWLLPRMSPIAVYSLVWYYFFHGSEIGTLNSILMKLGVISQPIPWGQTVPWGAWSIIIFVNGLVGVSFGMIVFTSALNQIPRELVIAARVDGASAWEISRKILIPLTKWHFLYVLTWQFLSLLTTYPHIFLLVQWDLVNRDYGTTLALYVFNTAFGRGEQDQGLAAAAAVILSIIGVIGGFVTLKVLQFEKMMKRPRGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMZ5</accession>
    <name>F0LMZ5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ni-Fe-hydrogenase III large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467422.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01148"/>
    <dbReference type="EnsemblBacteria" id="ADT84124">
        <property type="protein sequence ID" value="ADT84124"/>
        <property type="gene ID" value="TERMP_01148"/>
    </dbReference>
    <dbReference type="GeneID" id="10041465"/>
    <dbReference type="KEGG" id="tba:TERMP_01148"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1151"/>
    <dbReference type="eggNOG" id="arCOG01547">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01551">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_3_1_2"/>
    <dbReference type="OMA" id="GYDAGFM"/>
    <dbReference type="OrthoDB" id="4328at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="1">
        <location>
            <begin position="25"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="2">
        <location>
            <begin position="274"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="2">
        <location>
            <begin position="450"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="537" mass="61110" checksum="8E2F403006B929F6" modified="2011-05-03" version="1">MIIEILKGNDAKILRHDEKVILALVPNDKLRTTAELLFKAGCYYATGVGVDERLLGVGFSMYHIFNCESEKRYVILKTVANNSKIPSITPIISGANWAEREAMDMVGIFFDEHPEPLRLILPDDWPEGVHPLRKEFHYNERPPRIEFKPPKKEKKPGVMEVPVGPYHPTLHEPEVFELHVKGEEIVGAVYRGFHVHRGLEKLAEERMTINQIPFLAERICGICGYTHNCAYAQAVEDAAKIEVPERALYIRTILLELERLHSHLLWFGVAFHLLGFDSGFMHTWRIREAFMDLAELLTGNRKTYGMNLIGGVRRDIDEEKKKKVLEIFEKTKKETKEVLDNAAGMKELISRMEGVGVLPKKEGREIGVVGPVARASGIDTDVRRDHPYAAYGDLEFKVPVYKEGDVLARFLVRYEETFESFWLIEQALDQLPQGDILNEDYELPEYAVGIGATEAPRGEDVHFVITEGGNKVYRWRPRAPTYNNLPAVPIMLMGEKLADAPIIIASIDPCFSCTDHMVIVDGEKVCRCSLDEYLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN13</accession>
    <name>F0LN13_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01166"/>
    <dbReference type="EnsemblBacteria" id="ADT84142">
        <property type="protein sequence ID" value="ADT84142"/>
        <property type="gene ID" value="TERMP_01166"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01166"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1169"/>
    <dbReference type="eggNOG" id="arCOG11818">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3323183_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="38" mass="4445" checksum="51482A40B63BDA90" modified="2011-05-03" version="1">MNVFSNTLELYEKFKPTPLVRLSLSDERGDVFCQVRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN58</accession>
    <name>F0LN58_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Programmed cell death toxin YdcE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
            <plasmid evidence="2 3">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747419.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02224"/>
    <dbReference type="EnsemblBacteria" id="ADT85197">
        <property type="protein sequence ID" value="ADT85197"/>
        <property type="gene ID" value="TERMP_02224"/>
    </dbReference>
    <dbReference type="GeneID" id="10549048"/>
    <dbReference type="KEGG" id="tba:TERMP_02224"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2218"/>
    <dbReference type="eggNOG" id="arCOG02120">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116617_1_0_2"/>
    <dbReference type="OMA" id="DDNKWLE"/>
    <dbReference type="OrthoDB" id="110340at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="146" mass="17134" checksum="169DEC438547D32C" modified="2011-05-03" version="1">MKLVMDTNVVLAVMIKPRGLAALLIELLDKEHFINYTSQEALEELQIKMAILEEEGKLSKNWLQVLANFLYGTEIIEPKEHFNLCRDEDDNKLLDIAYDAKVQVILTWDDDLLDLRDDKKVLRLKDHQVKILKPIEFLKEELRKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN76</accession>
    <name>F0LN76_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
            <plasmid evidence="2 3">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747437.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02242"/>
    <dbReference type="EnsemblBacteria" id="ADT85215">
        <property type="protein sequence ID" value="ADT85215"/>
        <property type="gene ID" value="TERMP_02242"/>
    </dbReference>
    <dbReference type="GeneID" id="10549066"/>
    <dbReference type="KEGG" id="tba:TERMP_02242"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2236"/>
    <dbReference type="eggNOG" id="arCOG02408">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1478984_0_0_2"/>
    <dbReference type="OMA" id="HIANNLE"/>
    <dbReference type="OrthoDB" id="94671at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="182" mass="20341" checksum="D02D26B0D7E87E32" modified="2011-05-03" version="1">MKAAVLIDGENVVMCLRDVVGGKVHLDKDINWKKFFKYLESLDYEVTIARIYANPFIFLKNPHIANNLEKMGIKVVLADSTMKENGPKSTTDATMIVDGISILYERPAIDAIVIVSGDRDFLPLAEKAKELGRTVLFAAFPDSTANVIKNRYQVINLLEFSVLNATFDNNIYPNIEEISVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN99</accession>
    <name>F0LN99_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02265"/>
    <dbReference type="EnsemblBacteria" id="ADT85238">
        <property type="protein sequence ID" value="ADT85238"/>
        <property type="gene ID" value="TERMP_02265"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02265"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2259"/>
    <dbReference type="HOGENOM" id="CLU_1615389_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="164" mass="19778" checksum="30CD89918C11ACA2" modified="2011-05-03" version="1">MEVVQTQIVGFLKPAMKSPTEEPKVEFRTALEFEAIAERKRRAFEKWHPIIKKTEFLVIREHLRAKDVYGKDYIEKVLNVQFLAEILENYKVKAQIIIYEAYFEVKFFHHLSKVKYRKIVQEINRVTLQELNERAQWDKKEKVLKVPRVKEKPIDELMEVEIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGU8</accession>
    <name>F0LGU8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00009"/>
    <dbReference type="EnsemblBacteria" id="ADT82987">
        <property type="protein sequence ID" value="ADT82987"/>
        <property type="gene ID" value="TERMP_00009"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00009"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.8"/>
    <dbReference type="eggNOG" id="arCOG10219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020529_0_0_2"/>
    <dbReference type="OMA" id="ITIKTFV"/>
    <dbReference type="OrthoDB" id="138231at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014628">
        <property type="entry name" value="Man6P_isomerase_Firm_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036894">
        <property type="entry name" value="PMI_Firm_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT82987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="282" mass="31875" checksum="097B5C3844E9BDCE" modified="2011-05-03" version="1">MFEFIEHSGDVIKKVWGTETWIFSAHPENPSVVEVRGEEYNFLDLLRKHREYILGNIECSDFPILVKIIDPNETLSVQVHPSEEDAKKLGENDHGKEEAWVVLSDRGFVYLGFEGDFSELEGDVIKKMHRVDVKRLDSINIPSGTLHALGAGTKVLEVSTNSNITYRVYDFGRGRELHLDKAKKVVKKRSLDELLLGSIRDKPLNTEFFRIEYLHLRGSKEFLVDSFVIIVCTAGKANITGKQEKTYIDSTKHVLVPGSIGRFVVEGNAELFIISPGKQCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGW3</accession>
    <name>F0LGW3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466300.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00024"/>
    <dbReference type="EnsemblBacteria" id="ADT83002">
        <property type="protein sequence ID" value="ADT83002"/>
        <property type="gene ID" value="TERMP_00024"/>
    </dbReference>
    <dbReference type="GeneID" id="10040343"/>
    <dbReference type="KEGG" id="tba:TERMP_00024"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.23"/>
    <dbReference type="eggNOG" id="arCOG01215">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063016_0_0_2"/>
    <dbReference type="OMA" id="GPEGWNE"/>
    <dbReference type="OrthoDB" id="58084at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050531">
        <property type="term" value="F:mannosyl-3-phosphoglycerate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051479">
        <property type="term" value="P:mannosylglycerate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006381">
        <property type="entry name" value="HAD-SF-IIB-MPGP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033980">
        <property type="entry name" value="MPG_Pase_thermophiles"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01142">
        <property type="entry name" value="C2.B.2:_Mannosyl-3-phosphoglyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01486">
        <property type="entry name" value="HAD-SF-IIB-MPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02461">
        <property type="entry name" value="osmo_MPG_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="245" mass="28380" checksum="7A3592276DDDD766" modified="2011-05-03" version="1">MRVIFLDLDKTLIGDDYSPEPAKQIIDELKRRGFRIIFNSSKTRAEQEYYRKALNVEDPFIVETGSAIYIPKNIFPFKFNFTRETQKYFIIELGESYRKIQNVLSEISWVFGLKYYGNSTIEEIMKFTGLPKHLAELAARREYSETIFRWRNEKFVDIIKSKGLTVSKGSRFYNVHGNTNKGKAAHVLLLLYSKLFGDVESYAVGDSFNDFPLFEVVDKAFIVGNLKHPEAVNISSIKEVLEVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGX4</accession>
    <name>F0LGX4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagella protein FlaD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467480.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01206"/>
    <dbReference type="EnsemblBacteria" id="ADT84182">
        <property type="protein sequence ID" value="ADT84182"/>
        <property type="gene ID" value="TERMP_01206"/>
    </dbReference>
    <dbReference type="GeneID" id="10041523"/>
    <dbReference type="KEGG" id="tba:TERMP_01206"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1209"/>
    <dbReference type="eggNOG" id="arCOG02964">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047519_0_0_2"/>
    <dbReference type="OMA" id="YYEIGWI"/>
    <dbReference type="OrthoDB" id="71124at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006752">
        <property type="entry name" value="Arch_fla_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016682">
        <property type="entry name" value="FlaD_prd_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04659">
        <property type="entry name" value="Arch_fla_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017066">
        <property type="entry name" value="FlaD_arch_prd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arch_fla_DE" evidence="1">
        <location>
            <begin position="145"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="266" mass="31372" checksum="4FF3C6E99E3A59B6" modified="2011-05-03" version="1">MITEIEIEERLKKLRGKIPNVLIEDLRERLLSKMDILTPEQVDKIIERILQTYSGQVERLIKLDKRVEEIGKHIEEIRSYLIEKKGIGRDQAIIEEMAVEEKLPPNYEEIDITNSEKVKKEEEIMEKSFEIPQEIKDVLAVSSNGKARLERIPQDMTSTMIALKWLGFLIDRVGMQNLENILEFYYEIGWISENVLNTLLKYANGTKPHHREPNWRPEDKLTIQDHLISLLFIERLRGVRITREILDSIEREMKVINRILEEVYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGZ3</accession>
    <name>F0LGZ3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glyceraldehyde 3-phosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467499.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01225"/>
    <dbReference type="EnsemblBacteria" id="ADT84201">
        <property type="protein sequence ID" value="ADT84201"/>
        <property type="gene ID" value="TERMP_01225"/>
    </dbReference>
    <dbReference type="GeneID" id="10041542"/>
    <dbReference type="KEGG" id="tba:TERMP_01225"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1226"/>
    <dbReference type="eggNOG" id="arCOG02291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_3_2"/>
    <dbReference type="OMA" id="AGFFKPH"/>
    <dbReference type="OrthoDB" id="93004at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011950">
        <property type="entry name" value="HAD-SF_hydro_IA_CTE7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02253">
        <property type="entry name" value="CTE7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="232" mass="26668" checksum="0D1AB03D6905649F" modified="2011-05-03" version="1">MIKAVFFDFVGTLLSKESEAVTHLKIMEEVLKNANAEINTKQLLEEYDHLTKEEFSKLAGKPYKPIRIIEVEITERLAKKYNFEVPEDFWQIHLKMHQLYGKLYPEVVETLKELRKRGYHVGLITDSDNDYLRAHLEALGIFDLFDSITTSEEAGFFKPHPKVFETALKKAGVKGEEAVYVGDNPLKDCVGARQVDMISILLDKTGEKRELWGECEFIISDLKEVLDIVSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH00</accession>
    <name>F0LH00_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type multidrug transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01232"/>
    <dbReference type="EnsemblBacteria" id="ADT84208">
        <property type="protein sequence ID" value="ADT84208"/>
        <property type="gene ID" value="TERMP_01232"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01232"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1233"/>
    <dbReference type="eggNOG" id="arCOG01465">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089201_0_0_2"/>
    <dbReference type="OMA" id="WAWELRW"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="30"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="263" mass="29636" checksum="F19DC3760267FE1C" modified="2011-05-03" version="1">MYLAKASLLTAKRYKIDWYGNVLMPILGVLPVIIAIWFGNKLGLLNFSSIIGTENLLEYYVLGIAYWNYIESVWSSIFSLREHMRIGQLEELILTPLKPWEYILGWSFLSFALTTVSSLPLILIALLLNVQHLNIEKLILAVLIFLISLIASFGFAFLIFGLTLVVKEGDEIVSLLGNAAPLLGGLYFPIAILPIPLRYLAYSLPFTWSLDLLRALLLSSKTILNIGSEIKVFLLLSFGYFALGTVSYILLERKMRKRGIHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH28</accession>
    <name>F0LH28_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467534.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84236">
        <property type="protein sequence ID" value="ADT84236"/>
        <property type="gene ID" value="TERMP_01260"/>
    </dbReference>
    <dbReference type="GeneID" id="10041577"/>
    <dbReference type="KEGG" id="tba:TERMP_01260"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1263"/>
    <dbReference type="eggNOG" id="arCOG03957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051317_0_0_2"/>
    <dbReference type="OMA" id="ETTHVES"/>
    <dbReference type="OrthoDB" id="80859at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01048">
        <property type="entry name" value="Ferritin_like_AB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019243">
        <property type="entry name" value="DUF2202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09968">
        <property type="entry name" value="DUF2202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2202" evidence="1">
        <location>
            <begin position="68"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="240" mass="26930" checksum="2709A2F5213CDCA8" modified="2011-05-03" version="1">MRKLLALFVIVILLGVVSSSGCVGETKTETATVTDTIPLTADTNGNVNTQELQSYIESLPAGELTEAEKDGLLYMVEEEKLAHDVYTKLYEKWGLQIFSNIAKSETTHVESVRMLLKKYNLPDPTADSKIGEFKNKKLQDLYNKLIEQGMKSEIDALKVGALIEEVDIIDLQERIAETNKLDIITVYENLMMGSRNHLRAFVSQLKNRGVTYEPQVLPKDEYEQIISSPMEKGQGMGEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH38</accession>
    <name>F0LH38_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Predicted metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01270"/>
    <dbReference type="EnsemblBacteria" id="ADT84246">
        <property type="protein sequence ID" value="ADT84246"/>
        <property type="gene ID" value="TERMP_01270"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01270"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1273"/>
    <dbReference type="eggNOG" id="arCOG01138">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116765_4_2_2"/>
    <dbReference type="OMA" id="GIFHSHL"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="JAB_MPN" evidence="6">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="122" mass="13909" checksum="41E31211F703535B" modified="2011-05-03" version="1">MILERAKESKIEICGFLLGKQQDDVIVVKEVIFTKNKLNSPTAFEIDPLEIVEVLDYADEKNLEPVGIFHSHLCKPIPSGRDIRGMKLWRNVWLIVDNKGSYGAFILKDGKIKEVEVEVIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH62</accession>
    <name>F0LH62_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466322.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00046"/>
    <dbReference type="EnsemblBacteria" id="ADT83024">
        <property type="protein sequence ID" value="ADT83024"/>
        <property type="gene ID" value="TERMP_00046"/>
    </dbReference>
    <dbReference type="GeneID" id="10040365"/>
    <dbReference type="KEGG" id="tba:TERMP_00046"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.47"/>
    <dbReference type="eggNOG" id="arCOG03792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102063_2_0_2"/>
    <dbReference type="OMA" id="EYESTTH"/>
    <dbReference type="OrthoDB" id="118713at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005489">
        <property type="entry name" value="DUF257"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03192">
        <property type="entry name" value="DUF257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="215" mass="25229" checksum="1A764B4953671850" modified="2011-05-03" version="1">MQKSIKEFLEKVQPGETILIEYSSIDHPEIVFYSITKWAEENGLPIVIHDVLDTFHIFVEHLKLNGYDVEFLKDVYVIKSGGMIQLGKIIRKVKLSDDIVVYTRNLHEILRELFTKIEKRPIIIIVLGAGKHLKRYEHQPRVLEYFFEVVTRKCLGNTNRITYLFGNPHLLRHDVKVELEEAPTRILELKEYGRKVVIKKSPYLSELMEELEVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH76</accession>
    <name>F0LH76_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00060"/>
    <dbReference type="EnsemblBacteria" id="ADT83038">
        <property type="protein sequence ID" value="ADT83038"/>
        <property type="gene ID" value="TERMP_00060"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00060"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.60"/>
    <dbReference type="HOGENOM" id="CLU_1700350_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="154" mass="17569" checksum="B7DB93F45B048E2F" modified="2011-05-03" version="1">MGVKIKELKIKKDRIMAGSGRRLYIFRVLHLSCLFGPFSEPLQVSNAAVVKGNTTYIISTDGIILLNNEGFLKAIQLQIPPTKVYADANWRYLALAWNKTICVFNSDLNPIYECKSFKNEITGVRLCGSYLTVCFKERIVKFKINQKIGKFVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHC0</accession>
    <name>F0LHC0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">30S ribosomal protein S4e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps4e</name>
        <name evidence="9" type="ordered locus">TERMP_00104</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466380.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00104"/>
    <dbReference type="EnsemblBacteria" id="ADT83082">
        <property type="protein sequence ID" value="ADT83082"/>
        <property type="gene ID" value="TERMP_00104"/>
    </dbReference>
    <dbReference type="GeneID" id="10040423"/>
    <dbReference type="KEGG" id="tba:TERMP_00104"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.105"/>
    <dbReference type="eggNOG" id="arCOG04093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060400_0_0_2"/>
    <dbReference type="OMA" id="FPVGLMD"/>
    <dbReference type="OrthoDB" id="89943at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="KOW_RPS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_S4e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_S4e_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_S4e_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_S4e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_S4e_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="PTHR11581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="44"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="248" mass="28402" checksum="8AFDE0AA582E95DF" modified="2011-05-03" version="1">MARKGAKRHLKRLAAPTQWYIERKAYKWAVRPRPGPHNMRTSIPLLYIVRDYLGYAKTAREARKILNEGKILVDGKARKDYKFPVGIMDVVSIPETGEHYRVLPNRIGKLILHPISEEEAKIKPLRITRKVMVKGGNLQIGFHDGTNYLVKLSSLTDEVKDRFKTSYTVFMKMPEREITEILPFEIGAYVFVTQGKNVARIGKIVEVRHFPAGWPDVVTIEDQEGELFDTLKEYAFVIGKDKPGISLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHC9</accession>
    <name>F0LHC9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467554.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01281"/>
    <dbReference type="EnsemblBacteria" id="ADT84256">
        <property type="protein sequence ID" value="ADT84256"/>
        <property type="gene ID" value="TERMP_01281"/>
    </dbReference>
    <dbReference type="GeneID" id="10041597"/>
    <dbReference type="KEGG" id="tba:TERMP_01281"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1283"/>
    <dbReference type="eggNOG" id="arCOG03458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140894_3_1_2"/>
    <dbReference type="OMA" id="HLHYIAG"/>
    <dbReference type="OrthoDB" id="114018at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="PTHR12608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="87" mass="9306" checksum="14CA70FC12C2B32B" modified="2011-05-03" version="1">MKEVLYVFVAIFLAELGDKTQLATIAFASKYGWAKAFTGAILGLALVNLIGAFVGEKIGEALPVEIIHKGAGVLFIIFGLLMFFGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHF5</accession>
    <name>F0LHF5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nonspecific lipid-transfer protein, acethyl CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467580.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01307"/>
    <dbReference type="EnsemblBacteria" id="ADT84282">
        <property type="protein sequence ID" value="ADT84282"/>
        <property type="gene ID" value="TERMP_01307"/>
    </dbReference>
    <dbReference type="GeneID" id="10041623"/>
    <dbReference type="KEGG" id="tba:TERMP_01307"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1308"/>
    <dbReference type="eggNOG" id="arCOG01278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_4_0_2"/>
    <dbReference type="OMA" id="PSLYAMM"/>
    <dbReference type="OrthoDB" id="44046at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="2">
        <location>
            <begin position="261"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="386" mass="41053" checksum="8172C8B5F13BA7FC" modified="2011-05-03" version="1">MKKAVIIGVGMTPVGEHWKTSLRDLAVEALLNAMDDANLDKVDSLYVGNMISGPFVEQENLGALIADWAGLGHIPAVKIEAACASGGAAVQEGAKAVMSGLEDVVAVVGVEKMTDAWPSDATRYLAYASDAEWELFHGASFVALNALVMRYYMHTYGYTEEDLALFAVNAHINGAKNPYAMFKKPIKVETVLRSPYIADPLKLFDASPVCDGAAAVIITTPEKAKELGIPKEKWVEIAGMGRAIDTINLANRKDLLRLKAAEVAAERAYKMAGIEAKDVDLFEVHDAFTIMAALSLEAVGAAERGKGAELAKEGQIAIDGDYPIQTMGGLKSRGHPVGATGVYQTVEAALQLRGEAPNQVPDAEIALTQNIGGTGSNITVTILRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHG7</accession>
    <name>F0LHG7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467592.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84294">
        <property type="protein sequence ID" value="ADT84294"/>
        <property type="gene ID" value="TERMP_01319"/>
    </dbReference>
    <dbReference type="GeneID" id="26136800"/>
    <dbReference type="KEGG" id="tba:TERMP_01319"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1320"/>
    <dbReference type="eggNOG" id="arCOG03461">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203610_0_0_2"/>
    <dbReference type="OrthoDB" id="127812at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="47" mass="5618" checksum="FECF6DB86ECB3692" modified="2011-05-03" version="1">MAVLKAIKVRDRDGEIFFRCPRCGMVFKRSKDYIKHINRAHGHLFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHL1</accession>
    <name>F0LHL1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00117</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466393.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00117"/>
    <dbReference type="EnsemblBacteria" id="ADT83095">
        <property type="protein sequence ID" value="ADT83095"/>
        <property type="gene ID" value="TERMP_00117"/>
    </dbReference>
    <dbReference type="GeneID" id="10040436"/>
    <dbReference type="KEGG" id="tba:TERMP_00117"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.118"/>
    <dbReference type="eggNOG" id="arCOG02673">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121274_0_0_2"/>
    <dbReference type="OMA" id="LGWYILC"/>
    <dbReference type="OrthoDB" id="94214at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038978">
        <property type="entry name" value="MJ0935"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42198">
        <property type="entry name" value="PTHR42198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="173" mass="20477" checksum="5063F1E5EBBB8307" modified="2011-05-03" version="1">MLEPIYAVLDKVFGPLLVSTHPLWVVTISGILLGAFFTLVNYFLVDQEKMKRLQKLSKEFQKEWNEAKKSGDEKKLRKLQQKQMELLKLQNEVMKDTFFKPMLVTMPIFWIFFGWMRRWYTEVVVVKLPFNFFLADFFHKSSALHANELGYIGWYILTSMVVGQVLRKLLDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHL2</accession>
    <name>F0LHL2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L34e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl34e</name>
        <name evidence="7" type="ordered locus">TERMP_00118</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466394.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00118"/>
    <dbReference type="EnsemblBacteria" id="ADT83096">
        <property type="protein sequence ID" value="ADT83096"/>
        <property type="gene ID" value="TERMP_00118"/>
    </dbReference>
    <dbReference type="GeneID" id="26135434"/>
    <dbReference type="KEGG" id="tba:TERMP_00118"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.119"/>
    <dbReference type="eggNOG" id="arCOG04168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118652_2_0_2"/>
    <dbReference type="OMA" id="SWRRKYV"/>
    <dbReference type="OrthoDB" id="119402at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00349">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_L34Ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_L34e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="PTHR10759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="89" mass="10506" checksum="4F758A24787866A2" modified="2011-05-03" version="1">MKPMYRSRSWRRKYVRTPGGRTVIHFERRKPKIAHCAMCGRPLNGIPRGRPSELRKLPKTKKRPERPMPHLCPSCMRKVMKAQVRAQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHN8</accession>
    <name>F0LHN8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isopentenyl-diphosphate delta-isomerase</fullName>
            <shortName evidence="7">IPP isomerase</shortName>
            <ecNumber evidence="7">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Isopentenyl diphosphate:dimethylallyl diphosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Type 2 isopentenyl diphosphate isomerase</fullName>
            <shortName evidence="7">IDI-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fni</name>
        <name evidence="9" type="ordered locus">TERMP_00145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the IPP isomerase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466420.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00145"/>
    <dbReference type="EnsemblBacteria" id="ADT83122">
        <property type="protein sequence ID" value="ADT83122"/>
        <property type="gene ID" value="TERMP_00145"/>
    </dbReference>
    <dbReference type="GeneID" id="10040463"/>
    <dbReference type="KEGG" id="tba:TERMP_00145"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.146"/>
    <dbReference type="eggNOG" id="arCOG00613">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065515_1_0_2"/>
    <dbReference type="OMA" id="WDWGIPT"/>
    <dbReference type="OrthoDB" id="42330at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02811">
        <property type="entry name" value="IDI-2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00354">
        <property type="entry name" value="Idi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="PTHR43665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003314">
        <property type="entry name" value="IPP_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02151">
        <property type="entry name" value="IPP_isom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_dh" evidence="8">
        <location>
            <begin position="11"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_dh" evidence="8">
        <location>
            <begin position="183"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="68"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="279"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="300"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="373" mass="41325" checksum="5489A8C59770C27E" modified="2011-05-03" version="1">MGKEELTIIRKFEHIEHCLKRQVEAHVTNQFENIHFVHTSLPEIDKDEIDLSVEFLGRKFDYPIMIAGMTGGTKGSQLAGRINKTLAKAAQELNIPMGVGSQRAMIRNPETWESYYVRDVAPDIFLIGNLGAPQFAETMPDRYGIEEALKAVETIQADALAIHMNPLQESVQPEGDTQYRGILKALAELKSEFPYPIIAKETGAGVSMEVAIKLESIGIDAVDVGGLGGTSWSGVEYYRAKDERSRNLALKFWDWGIPTAISVVEVKYATDLPIIATGGIRDGIMIAKALALGANLAGVALPLLKPAVKGDVEGVIRVLQRYIDELRNAMFLVGARDVEELRKVPLVITGFAKEWLEQRIDLAEFLRVRRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHR6</accession>
    <name>F0LHR6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466448.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00173"/>
    <dbReference type="EnsemblBacteria" id="ADT83150">
        <property type="protein sequence ID" value="ADT83150"/>
        <property type="gene ID" value="TERMP_00173"/>
    </dbReference>
    <dbReference type="GeneID" id="10040491"/>
    <dbReference type="KEGG" id="tba:TERMP_00173"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.174"/>
    <dbReference type="eggNOG" id="arCOG01565">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070736_0_0_2"/>
    <dbReference type="OMA" id="CHHNADP"/>
    <dbReference type="OrthoDB" id="47681at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="230"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="325" mass="36255" checksum="5D0455D219C0EE5B" modified="2011-05-03" version="1">MRGKIKLKRFLGEAKEKEYSFLLLCHHNADPDSLGSAIAFSRYLNSMGLNNRIGVAQSVSSYAKRLLSFAKVEKDPEVKEDVVIIFDTSSIEQLEPVEIPKDKFVIVIDHHIEKENPIKAHIRIVDSSRTSTAEIVWELLKYFNFYDEIAAKAILAGIATDTANFRYANAKTFKTVSEILERFPIQMGEIYNLTAPVSDENIDQAKRMAILKACQRMEIKKFRKYIIVTSKVSAYESLACKVFLQLGADVAIVGSEKKGVRISARAKEHLVKRGLHLGKIMEKVGPIIEGSGGGHAGAAGANGKRNLDEAIKFLVKEIEKFLRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHS3</accession>
    <name>F0LHS3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00180"/>
    <dbReference type="EnsemblBacteria" id="ADT83157">
        <property type="protein sequence ID" value="ADT83157"/>
        <property type="gene ID" value="TERMP_00180"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00180"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.181"/>
    <dbReference type="eggNOG" id="arCOG00722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154570_4_2_2"/>
    <dbReference type="OMA" id="RIQAYPY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="89" mass="10263" checksum="F4DC6516286CE3ED" modified="2011-05-03" version="1">MEVIKISVKRDIIESLKFYNKDLKDLEREAKVLLAIELFKEGVLSLEQAAEFAELPLQKFIDELKAHNVPILEYDESELEEELASVNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHV8</accession>
    <name>F0LHV8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467656.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01383"/>
    <dbReference type="EnsemblBacteria" id="ADT84358">
        <property type="protein sequence ID" value="ADT84358"/>
        <property type="gene ID" value="TERMP_01383"/>
    </dbReference>
    <dbReference type="GeneID" id="10041699"/>
    <dbReference type="KEGG" id="tba:TERMP_01383"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1383"/>
    <dbReference type="eggNOG" id="arCOG04347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_7_3_2"/>
    <dbReference type="OMA" id="VNWAARH"/>
    <dbReference type="OrthoDB" id="49237at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="43"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="202" mass="23143" checksum="3C5B6C07345C959C" modified="2011-05-03" version="1">MAETAKKYDRFSKFYDLFEALIESRAFSKYRRKALSLAKGKVLEVGVGTGKNLPYYPKDVEVIGIDFSKGMLEKAEKRRKELGLKNVRLLLMDAQNLEFEDNSFDTVVSTFVFCTVPDPIKGLREAYRVLKPGGRAIFLEHMKSESRLLNVPLYLMDPVMRALTGTSMVRETQKNIKKAGFKIERVENLFFDIVRLIIATKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHW7</accession>
    <name>F0LHW7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01392"/>
    <dbReference type="EnsemblBacteria" id="ADT84367">
        <property type="protein sequence ID" value="ADT84367"/>
        <property type="gene ID" value="TERMP_01392"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01392"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1392"/>
    <dbReference type="eggNOG" id="arCOG03682">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035393_0_0_2"/>
    <dbReference type="OMA" id="DFRERAN"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="145"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="492" mass="55253" checksum="81A3E74F82DFC44C" modified="2011-05-03" version="1">MKDLLRKSVIIELPPKVHAGEEIPLRIGFRNLLRGTINVEIDLGDLSRHLDLSSTRVYFRAVRPGEYVSQTVTAVPRGRGRVSAKVVVRSGMVSAKVKVRTEIIERTGIEPKTPVPAPVPVPAGNRQDSTGGTPRTPLEELFARYRKVEPIGEGGFARVYRAEKHDGSVVALKVPLSLTEEGGKTFLREVRNWSLLSHPNIVELYDYNIFPLPYLEMEYCETSLAKLEKPLSPEKAARIIFDVAEGLKYAHSKGVIHRDLKPSNILLKGGRAKVSDWGLSKLLKESRTTHTVSFTPLYAAPEQISSRFGGTDERTDVWQIGAVLYELLTGRPPFEGEDFVEVASKITLEEPVPPGQLNPDAKPLEPVVMKCLAKRKEERYQSVEELQRDLAEFLGKNYRENLSKSVSINDLSRSAYYAGELFLLYLKLNDLVNALKYADDLAHYARGEVREELLSLREQLRLRLENGLDVPEELVEKAEIIIHKIKLGFEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI13</accession>
    <name>F0LI13_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsZ</name>
        <name evidence="9" type="ordered locus">TERMP_00190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466465.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
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    <dbReference type="EnsemblBacteria" id="ADT83167">
        <property type="protein sequence ID" value="ADT83167"/>
        <property type="gene ID" value="TERMP_00190"/>
    </dbReference>
    <dbReference type="GeneID" id="10040508"/>
    <dbReference type="KEGG" id="tba:TERMP_00190"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.191"/>
    <dbReference type="eggNOG" id="arCOG02201">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_0_1_2"/>
    <dbReference type="OMA" id="GNPSIGQ"/>
    <dbReference type="OrthoDB" id="41117at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0003924">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 6 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="43"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="236"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="51"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="373" mass="39892" checksum="D0D8777BF4605995" modified="2011-05-03" version="1">MLKLIESAIERTSQEAGKVNEVQVPQSDVDEELRRILEQIQAKIYVVGVGGAGCNTINRMMEVGIQGAKVIAINTDAQDLLKVRAHKKILIGKDLTRGLGAGNNPKIGEEAAKESEKDIRDALEGADMVFITCGLGGGTGTGAAPIVAELAKKMGALTVSVVTLPFTVEGIRRIKNAEYGLERLRKNSDTVIVIPNDKLMEVAPNLPIHLAFKVADEILVQAVKGITELITKPGLVNLDFADVRAVMKDGGVAMIGIGESDSEKRALEAATQALNSPLLDVDISGAKGALISIAGSDVKLEEAQQIIELVTSKLDPEAQVIWGIQLDEELGKTIRVMVVVTGVSSPYAVVEEEATYFSEEGERKVIHLDLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI30</accession>
    <name>F0LI30_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83184.1"/>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
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    <dbReference type="EnsemblBacteria" id="ADT83184">
        <property type="protein sequence ID" value="ADT83184"/>
        <property type="gene ID" value="TERMP_00207"/>
    </dbReference>
    <dbReference type="GeneID" id="26135536"/>
    <dbReference type="KEGG" id="tba:TERMP_00207"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.207"/>
    <dbReference type="eggNOG" id="arCOG00666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="361" mass="40515" checksum="799E64A041F99B86" modified="2011-05-03" version="1">MQAVIMAGGKGTRLLPLTVYRPKPMIPFFNKPLMEYILRSLIDAGVDEIFVLVGYLKERIMDYFGDGSEFGVEIHYSNGENIKLGTAGATKKVVDKIEDTFIVASSDVLTNLDIKALYEYHKKKKALATIALSEVEDPTQYGIAIVDNENRIIRFKEKPKPEEAFSNLVNAGIYVFEPEVFDLIPPKTNFDYSLHLFPKMLEENLPLYGFPFKEYWNDVGRPSSYLQATEDVFLGKLRLPEIRVDTLKGNLEYGGAIVTGRRCKLRKFEVRGFAVLGNNVEIGRNVKIERSVIFSNVTIEEGAEIREAIIGENVYIGKGVEIEAGSVIGDNTVIEEFSKVGANVKIWVESRIGKESIILPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI35</accession>
    <name>F0LI35_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466487.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83189">
        <property type="protein sequence ID" value="ADT83189"/>
        <property type="gene ID" value="TERMP_00212"/>
    </dbReference>
    <dbReference type="GeneID" id="10040530"/>
    <dbReference type="KEGG" id="tba:TERMP_00212"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.212"/>
    <dbReference type="eggNOG" id="arCOG03818">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_638768_0_0_2"/>
    <dbReference type="OMA" id="GLFPQFW"/>
    <dbReference type="OrthoDB" id="30015at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="429" mass="46845" checksum="AFA4879EC14FC182" modified="2011-05-03" version="1">MEERTKWTIYLTFLVAGFATGIGTMGLFPQFWLQYGITGLTVYLIFTLFFTYLAILEAESTQKTAYHFVELYTKLTRTSGMIIAILLAIMVFLSYYTANTALILLSPFLGTGALGRLIAKLILLAVTFIIITRAKEKTFLIMAGGSALFVIFAVITAIAFKTKIPAENFYLDLVKGMIFARQPLSLALLRDAAIRALYGVGLGFAFYLMIGSFMGRNFNSKVIIGTGVAIQVFIGIIATFTVIYSVAPGTPGLLLTYATGGEEGSIKFMEALPHVLANYQILLLMIAMSLFFAGLTSIVPTAEIGLQITQMLTGLSREKAATYFISFVVLLGIIDSYPPVADMMLQAINVFIFIGAIFEIYPILTKLRRQKSPVEHAIATVGAVVFALLGIYVMISEIRIGGYRVVSTVIAIVLLIIGIAIKEFGKASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI78</accession>
    <name>F0LI78_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ARMT1-like_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00255"/>
    <dbReference type="EnsemblBacteria" id="ADT83232">
        <property type="protein sequence ID" value="ADT83232"/>
        <property type="gene ID" value="TERMP_00255"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00255"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.255"/>
    <dbReference type="eggNOG" id="arCOG04410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071520_1_0_2"/>
    <dbReference type="OMA" id="FLLKAKC"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014444">
        <property type="entry name" value="PH1575-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006593">
        <property type="entry name" value="UCP006593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="SSF111321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARMT1-like_dom" evidence="1">
        <location>
            <begin position="3"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="273" mass="31008" checksum="914740D4A0294D65" modified="2011-05-03" version="1">MLQCQRIAEFSTEDLEKRRGAMIFSSKLFADYFNENSIPAVVGSEIFLRLYEYLGVNDPFKGYKEMSNKLARKVADDLKRKLKIDLNTALKLAIAGNVIDFAVGYNPEKIEEDILEMIKEGLYIDESKKLFNTLKMSKILLYITDNCGEIYFDKLLLEKIREEFPKLEVYIAGKEDAIINDATVNDLKEAGIDKFGKIISTGTRIVGVPMNKVSRDFIEIFNKADVIIAKGQGNFETLSEIKDDRVFFLLKAKCKPVARELNVPQGAMICKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI85</accession>
    <name>F0LI85_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01440"/>
    <dbReference type="EnsemblBacteria" id="ADT84415">
        <property type="protein sequence ID" value="ADT84415"/>
        <property type="gene ID" value="TERMP_01440"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01440"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1440"/>
    <dbReference type="eggNOG" id="arCOG07113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155021_0_0_2"/>
    <dbReference type="OMA" id="MEELCEC"/>
    <dbReference type="OrthoDB" id="111487at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="91" mass="10594" checksum="3C8C169559E7BC49" modified="2011-05-03" version="1">MLIARPCTSMKAINITPEEKYDIDMEELCECLAERGFQIKRVTRFLALVKKKYDISVFPSGKVIVKDTDDKEEALKIAKEIYECMEPYRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIB1</accession>
    <name>F0LIB1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3'-phosphoadenosine 5'-phosphosulfate sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467739.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01466"/>
    <dbReference type="EnsemblBacteria" id="ADT84441">
        <property type="protein sequence ID" value="ADT84441"/>
        <property type="gene ID" value="TERMP_01466"/>
    </dbReference>
    <dbReference type="GeneID" id="10041782"/>
    <dbReference type="KEGG" id="tba:TERMP_01466"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1466"/>
    <dbReference type="eggNOG" id="arCOG00072">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_632571_0_0_2"/>
    <dbReference type="OMA" id="IVPWSGG"/>
    <dbReference type="OrthoDB" id="49767at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="1">
        <location>
            <begin position="236"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="423" mass="49127" checksum="2B44BA64B92BEF31" modified="2011-05-03" version="1">MFHVIVRARKDAKALQYINKRNYGGFLKVSSLGGGRKFNEVEDILEGLKDAPYIPILLFGEKERELARDITAYFFELRKPFYSRILRTKKVRNMRVDELYTHLEEIKARFRLGIEWNGAYKLNPENPLGIEINPDYDIYLAFGDRFGENMREILGIDIGSVSLVLRKLMNQEVYYSGSMKIAEVSKRIGEETEVLWKIPYTEEISLEDIIKANESYIRAFEKASESFLKQFEGYDIIVPWSGGKDSTAALILASKVFRDVTAVYVKMEYEMPQTDEYVEKLAKKLKVNIIESFVKMPVDKYGFPTHNNRWCTRMKVEALYNAIKEFDSPVLVIGDRDGESAKRRLKPPAIERKNEVLGTFLEVMPIKFWSGMMVQLYILMNGFDLHPLYYEGFYRLGCTICPSLADWEITLLKKRGEKNLPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIE3</accession>
    <name>F0LIE3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane bound hydrogenase MbhA-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467771.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01498"/>
    <dbReference type="EnsemblBacteria" id="ADT84473">
        <property type="protein sequence ID" value="ADT84473"/>
        <property type="gene ID" value="TERMP_01498"/>
    </dbReference>
    <dbReference type="GeneID" id="10041814"/>
    <dbReference type="KEGG" id="tba:TERMP_01498"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1498"/>
    <dbReference type="eggNOG" id="arCOG03099">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086615_2_2_2"/>
    <dbReference type="OMA" id="ALYVHWI"/>
    <dbReference type="OrthoDB" id="78706at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34584">
        <property type="entry name" value="PTHR34584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019239">
        <property type="entry name" value="MrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="166" mass="18679" checksum="B971A473BE904051" modified="2011-05-03" version="1">MSFIAAFVWSFVLWLVLTAGTKGMLWSPEEVVAGIMFSAIVAYSTKNIIGEKTARFLNPIRLLEFIVYSIGPLFWGMVKANFDVAYRVITGKIRPGIVRVPVELENDAQYTILSNSITLTPGTLTIDACPEEKALYVHWIYVKEEEPKSSEPVSGSFEKWARRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIG9</accession>
    <name>F0LIG9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466541.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00266"/>
    <dbReference type="EnsemblBacteria" id="ADT83243">
        <property type="protein sequence ID" value="ADT83243"/>
        <property type="gene ID" value="TERMP_00266"/>
    </dbReference>
    <dbReference type="GeneID" id="10042540"/>
    <dbReference type="KEGG" id="tba:TERMP_00266"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.266"/>
    <dbReference type="eggNOG" id="arCOG01143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1105255_0_0_2"/>
    <dbReference type="OMA" id="YEAIMRP"/>
    <dbReference type="OrthoDB" id="58063at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="251" mass="28514" checksum="CB0F1811B693D514" modified="2011-05-03" version="1">MRYVAVLANINGNFPALVKALGKIEELKENGYDIEKYYILGNIVGLFPYPKEILDVLDDLIKSNKVKLIRGEFDQIIAMSDPHAEGPDYIDNISLPEHVKIALKYTWEKLDHDGREFIRDLPVYLVDKIGDNDIFGVYGSPLNPFGGIVLPEQPTSYYEAIMRPVKEYEILLVASPKIPVNVMTRYGRIVCPGSIGFPPGKEHKATFALIDVDTLHVKFVEVDYDKRIVEDKIKKEGLPEELIRILYHGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIJ9</accession>
    <name>F0LIJ9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0235 protein TERMP_00296</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466571.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00296"/>
    <dbReference type="EnsemblBacteria" id="ADT83273">
        <property type="protein sequence ID" value="ADT83273"/>
        <property type="gene ID" value="TERMP_00296"/>
    </dbReference>
    <dbReference type="GeneID" id="10040614"/>
    <dbReference type="KEGG" id="tba:TERMP_00296"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.296"/>
    <dbReference type="eggNOG" id="arCOG04058">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130694_6_0_2"/>
    <dbReference type="OMA" id="IGKINEW"/>
    <dbReference type="OrthoDB" id="123783at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005228">
        <property type="entry name" value="CHP00251"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="PTHR13420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00251">
        <property type="entry name" value="TIGR00251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="92" mass="10184" checksum="68D9EEF58F2BE07C" modified="2011-05-03" version="1">MIKQIKDGVILLVHVQPNTKRNSIEGVDKWKGRIKVKVSAPPVGGKANKELTKFLSKLLGKEVVILRGETSREKDLLIKGATIEEVKEKLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIL2</accession>
    <name>F0LIL2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466584.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00309"/>
    <dbReference type="EnsemblBacteria" id="ADT83286">
        <property type="protein sequence ID" value="ADT83286"/>
        <property type="gene ID" value="TERMP_00309"/>
    </dbReference>
    <dbReference type="GeneID" id="26135650"/>
    <dbReference type="KEGG" id="tba:TERMP_00309"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.309"/>
    <dbReference type="eggNOG" id="arCOG02219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_3_5_2"/>
    <dbReference type="OMA" id="NEMIMID"/>
    <dbReference type="OrthoDB" id="106818at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="124" mass="14061" checksum="3AF3337A53DE8456" modified="2011-05-03" version="1">MDAILDTSVIIEVFKGNSKVVKSLPSEWVYGLSAITVFELYCGTLKEKEELMIEKLPKLHFDEKSAKIAGEIYRDLKKKGNLPPAKDLLIAANAIAHDKMLITCDKDFELFTEYGLKVRIIKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIS7</accession>
    <name>F0LIS7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate:ferredoxin oxidoreductase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467827.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01554"/>
    <dbReference type="EnsemblBacteria" id="ADT84529">
        <property type="protein sequence ID" value="ADT84529"/>
        <property type="gene ID" value="TERMP_01554"/>
    </dbReference>
    <dbReference type="GeneID" id="10041870"/>
    <dbReference type="KEGG" id="tba:TERMP_01554"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1554"/>
    <dbReference type="eggNOG" id="arCOG01601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058423_0_0_2"/>
    <dbReference type="OMA" id="ATGCMEV"/>
    <dbReference type="OrthoDB" id="29720at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="57"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="315" mass="34872" checksum="36940926FB31BADA" modified="2011-05-03" version="1">MAVRKPPITTREYWAPGHAACAGCGCAIIMRLATKAFSEAMEEKYGDPDAFAIAHATGCMEVVSAVFPYTAWKAPWIHVAFENAAAVASGVEAAWKKLGYKGKILAFGGDGGTADIGLQALSGMLERRHNVVYIMYDNEAYMNTGIQRSSSTPYGAWTTTSPPGKYSIGEDKPKKWVALIAAAHQIPYVATASIADPYDLYRKVKKAAKIDGPAFLQIHGPCVPGWRIPPEKTVEVAKLAIETGVWPLFEIENGDIRNIKFQRFPKDGKFKKPIEEYLKLQGRFKHLFKRPEAIQELKEQIKAMWRVLGKEVELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIT6</accession>
    <name>F0LIT6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nac</name>
        <name evidence="6" type="ordered locus">TERMP_01563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Contacts the emerging nascent chain on the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Interacts with the ribosome. Binds ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467836.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01563"/>
    <dbReference type="EnsemblBacteria" id="ADT84538">
        <property type="protein sequence ID" value="ADT84538"/>
        <property type="gene ID" value="TERMP_01563"/>
    </dbReference>
    <dbReference type="GeneID" id="10041879"/>
    <dbReference type="KEGG" id="tba:TERMP_01563"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1563"/>
    <dbReference type="eggNOG" id="arCOG04061">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146475_0_0_2"/>
    <dbReference type="OMA" id="PRKMKQM"/>
    <dbReference type="OrthoDB" id="105165at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00814">
        <property type="entry name" value="NAC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005231">
        <property type="entry name" value="NAC_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="HYPK_UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00264">
        <property type="entry name" value="TIGR00264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="5">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="113" mass="12940" checksum="465CC90CCD10E84C" modified="2011-05-03" version="1">MFPMKGMNPKQMKRMMKQLGIKMEELEGVKEVVIRFENKEIIIREPVVTAIVAMGEKSYQIVGKEEVREVVNIPEEDIKLVMEQTGVDYETAKKALEETKGDLAEAILKLQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIW8</accession>
    <name>F0LIW8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="8">SHMT</shortName>
            <shortName evidence="8">Serine methylase</shortName>
            <ecNumber evidence="8">2.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glyA</name>
        <name evidence="11" type="ordered locus">TERMP_00337</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466612.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00337"/>
    <dbReference type="EnsemblBacteria" id="ADT83314">
        <property type="protein sequence ID" value="ADT83314"/>
        <property type="gene ID" value="TERMP_00337"/>
    </dbReference>
    <dbReference type="GeneID" id="10040655"/>
    <dbReference type="KEGG" id="tba:TERMP_00337"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.337"/>
    <dbReference type="eggNOG" id="arCOG00070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_2"/>
    <dbReference type="OMA" id="SHPAGLI"/>
    <dbReference type="OrthoDB" id="22518at2157"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="10">
        <location>
            <begin position="8"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8 9">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="425" mass="47462" checksum="A41D708EB72D6E30" modified="2011-05-03" version="1">MSYTEYKDKVLEFVEMHEKWRASTINLIASENVTSPSVTRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVDLFCKLFKSDFADLRPISGTNANQAAFFGLTQPGDNVIVLHTSHGGHISHMPFGAAGMRGLNVFTWPFDNESFNIDVDKAAQLIREKEPKLVVFGGSLFPFPHPVKELAPVAKEVGAYVMYDAAHVLGLIAGGEFQDPLREGADIITSSTHKTFPGPQGGVILYKNFGEDVAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEALAEEGFNVIGEDQGYTKSHQVIVDVSDLHEAAGGWAAPLLEEAGIILNKNLLPWDPLEKVNTPSGLRIGVQEMTRVGMMEDDMKEIARFMRRVLIDKEDPKKVEKEVFEFRKQFQKVYYSFDYGLPMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIY4</accession>
    <name>F0LIY4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466628.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00353"/>
    <dbReference type="EnsemblBacteria" id="ADT83330">
        <property type="protein sequence ID" value="ADT83330"/>
        <property type="gene ID" value="TERMP_00353"/>
    </dbReference>
    <dbReference type="GeneID" id="26135697"/>
    <dbReference type="KEGG" id="tba:TERMP_00353"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.353"/>
    <dbReference type="eggNOG" id="arCOG01097">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095256_1_0_2"/>
    <dbReference type="OMA" id="AYAEFVH"/>
    <dbReference type="OrthoDB" id="82596at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="3">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="2">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="171" mass="19283" checksum="AAFBC5276EE3882B" modified="2011-05-03" version="1">MVVKREMTKKFLSEAYAGESQAHMRYMIFAEVAEKEGFPNIAKLFRAIAFAELVHARNHLKALGGVKDTVENLQVAIDGETFEVEEMYPAYKAVAELQGENEAVRSTTYALEAEKIHAELYRKAKELAKEKKDIEIKKVYICPVCGYTAVDEAPEKCPVCGVPKEKFVVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIY5</accession>
    <name>F0LIY5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_00354</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="7 8">Binds 1 Fe(3+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the rubredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
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        </ligand>
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            <position position="9"/>
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        </ligand>
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        </ligand>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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                <person name="Marteinsson V.T."/>
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            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="ADT83376.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="207" mass="24111" checksum="1F5FA276E5FAE9F0" modified="2011-05-03" version="1">MPIPTPSTVPAFRKKIESIQNEQPKKKKPKKKEFRLVYIKIETKESKTVGEAAKELEINFKGFSPARLIEPDETNLLLAVEKFLKNNPPRIYIVELTDGISRWFYVFPSVEKIKFEEKRAYRVFVVKKKDAVKEILRRIVSGEFSGRFKLDFLTLLQILIGFVPFIFAYMAGQNSLQDLFNYLLWAVAVISAIQGIKRGYKEKSWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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                <person name="Marteinsson V.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="82" mass="9073" checksum="D95E71B9D7D079B0" modified="2011-05-03" version="1">MPKDQLYEIFGEVISSKHFLKAFIITVAATFIMYFAAPAIVKALGKEDLLKALRVTLSALGAFVGFIISSILIEPKRIVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ73</accession>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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            </authorList>
            <dbReference type="PubMed" id="21217005"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="tba:TERMP_01620"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1620"/>
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        <property type="component" value="Chromosome"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="207" mass="23574" checksum="7604350589E3D8CD" modified="2011-05-03" version="1">MHKIKDEWGEFLVKLARRAIEEYLKSGKIIKPPKDTPEELWEKMGVFVTLNRHGVPKQTALRGCIGFPLPIYPLVEATIKAAIYAAVDDPRFPPVSLDEMNNIIIEVSVLTPPELIEGPPEERPKKIKVGRDGLIIEKGIYSGLLLPQVPIEWGWDEEEFLAETCWKAGLPPDCWLDPDTKVYKFTAEIFEEEYPRGPVKRKPLSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ97</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4152 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
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            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
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            <taxon>Thermococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01644"/>
    <dbReference type="EnsemblBacteria" id="ADT84619">
        <property type="protein sequence ID" value="ADT84619"/>
        <property type="gene ID" value="TERMP_01644"/>
    </dbReference>
    <dbReference type="GeneID" id="26137158"/>
    <dbReference type="KEGG" id="tba:TERMP_01644"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1644"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="64364at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025206">
        <property type="entry name" value="DUF4152"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13680">
        <property type="entry name" value="DUF4152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4152" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="227" mass="25353" checksum="C5CA5D1FF19C0609" modified="2011-05-03" version="1">MRIVSADTGGAVLDGAYEPIGLIATAAVLIEKPFKTATMSIVKYADPFNYDLSGREAIKDEVFLAIKLAKKVKPDVIHLDSSLGGIELRKLDDPTIDALRISDRGKAIWHELSKDLQPLAKRFWEDTGIEILAIGKDSVAVRIAEIYAGIYSAKWAIEYAREEGSIRIGLPRYMKVEIHESRIYGESLDPREGGLYGEIESNNEGIGWELYPNPVARTFMVLEVWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJB6</accession>
    <name>F0LJB6_THEBM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84638">
        <property type="protein sequence ID" value="ADT84638"/>
        <property type="gene ID" value="TERMP_01663"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01663"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1662"/>
    <dbReference type="eggNOG" id="ENOG502N5BP">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_201553_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="60" mass="6739" checksum="7A83388F1E828ECF" modified="2011-05-03" version="1">MLPCGKVVDHLSEDVIEMFEHYYGGIPIDDAECLLCPYADRIILDFGFVINVCIASKFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJI1</accession>
    <name>F0LJI1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol-phosphate mannose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00470"/>
    <dbReference type="EnsemblBacteria" id="ADT83447">
        <property type="protein sequence ID" value="ADT83447"/>
        <property type="gene ID" value="TERMP_00470"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00470"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.470"/>
    <dbReference type="eggNOG" id="arCOG00895">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_4_2"/>
    <dbReference type="OMA" id="CYNEAQN"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="190" mass="21499" checksum="B58EF003D6ED64AF" modified="2011-05-03" version="1">MPDFIDEIIVVDDGSEDRTSEVARELGAEVIRLEQNQGKGRAMSEGIKKANGDIIVFIDADGQHKPEEIIKLVEPILNGEADFVIGSRLIKAQGERPLIRKISNFITTSLIRLKLGINVRDTQSGFRAIRREFLPEIESKRYEVETEVLIKAVKKGARVKEVPVSMIYGIETGHFRLEDILRFLHSLVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJP5</accession>
    <name>F0LJP5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467985.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01712"/>
    <dbReference type="EnsemblBacteria" id="ADT84687">
        <property type="protein sequence ID" value="ADT84687"/>
        <property type="gene ID" value="TERMP_01712"/>
    </dbReference>
    <dbReference type="GeneID" id="10042028"/>
    <dbReference type="KEGG" id="tba:TERMP_01712"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1711"/>
    <dbReference type="eggNOG" id="arCOG02969">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032882_0_0_2"/>
    <dbReference type="OMA" id="HEVAHNW"/>
    <dbReference type="OrthoDB" id="25615at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M1" evidence="1">
        <location>
            <begin position="302"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="555" mass="64151" checksum="F306A19BC244C1E9" modified="2011-05-03" version="1">MKIHLIVVIILTTLIVMCISSHRTELRELQFSPTANAKRLFEASWENNTANESISLSIIFDGWNATIKGTQEIELSLSSSSVIPFLFENSSILRFDLEKIEVYGAKVSVKAFYDGKYGILLLNVTPTRSTQKIRLFYTSHYQPLLDINMRDPIEWHMRSTKDYFYIPPEAYMFLSKLRGKFTIKVLHYSTDYTLAGILKLRNGKYKPLLPEEDAFHTDGKRLYILLGRWNIYESTIKINDRNIKVIALTDEGNVTNALSKILKVYSSHLIPYPYDELIYIRFKGHRSEYEGYGLYGGALGTQFKRVIPHEVAHNWFAMYADLGILNEPFAVYTSSLYNLTSEQVDKWEGLCLSLKDKTPIARINGITRQNMNTLYQRGGFILRSLQFVVGNETFFKGLRELLGICHAKDCTQPEETLNLIKEIYENLTNKDLDWFFKEWFYTADYPNFTVSSLKVIQNGNYYRLILNITEKNGFAMPLEVKIVTPTENITKRIFVNGSAILGVELKEKPLRVIIDPNDWMINADGSNYRVNWENFMLEKIEKEAMELNGVEIVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJR1</accession>
    <name>F0LJR1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01728"/>
    <dbReference type="EnsemblBacteria" id="ADT84703">
        <property type="protein sequence ID" value="ADT84703"/>
        <property type="gene ID" value="TERMP_01728"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01728"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1727"/>
    <dbReference type="eggNOG" id="arCOG05821">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152350_0_0_2"/>
    <dbReference type="OMA" id="NLDWDEL"/>
    <dbReference type="OrthoDB" id="126532at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="125" mass="14574" checksum="E64F23A456B66422" modified="2011-05-03" version="1">MLRIMLDSALHVLLIFMYYSFLKTAIEVFTYKKPRKLLLLTISIFGVFISLYIDIFLGFFFLFIMLLITGLNSREAIVSALTAEFGFIIALVVVMFILTTIGTIYNIPGFRFEIRFEELLRYMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJS4</accession>
    <name>F0LJS4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01741"/>
    <dbReference type="EnsemblBacteria" id="ADT84716">
        <property type="protein sequence ID" value="ADT84716"/>
        <property type="gene ID" value="TERMP_01741"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01741"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1740"/>
    <dbReference type="HOGENOM" id="CLU_219928_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="38" mass="4322" checksum="7E068291C465400F" modified="2011-05-03" version="1">MYMFGFGVFESFFSCSPYGKLTILKLEDEEVGFLGFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJV0</accession>
    <name>F0LJV0_THEBM</name>
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        <submittedName>
            <fullName evidence="4">Bmp family protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00510"/>
    <dbReference type="EnsemblBacteria" id="ADT83487">
        <property type="protein sequence ID" value="ADT83487"/>
        <property type="gene ID" value="TERMP_00510"/>
    </dbReference>
    <dbReference type="GeneID" id="10040828"/>
    <dbReference type="KEGG" id="tba:TERMP_00510"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.510"/>
    <dbReference type="eggNOG" id="arCOG00258">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="LASMMKR"/>
    <dbReference type="OrthoDB" id="22162at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Bmp" evidence="3">
        <location>
            <begin position="60"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="439" mass="47612" checksum="39941C685A51EB2B" modified="2011-05-03" version="1">MKRSVLALFLIGVLAFSVVASGCIGGEKTTTPTQTQSSPATSSPTQTATEEKPKLKGAIAVVYDIGGRGDLSFNDMAYMGASKAAKDFGLELKEVQSKSESDYLPNLRLLAQSGKYDLIIAVGFMMTDAVKQVADEFPNQKFAIVDGFIPDKPNVVSILFKENEGSALAGALAGLIAANDGKDKVGIVLGIEIPVLYKFEGGYRFGIKWAEDYYKKKTGKDVNIEVLYTYTGSFTDPAKGKTAAQAQLGQGAWVIYQVAGAVGLGVFDAVSEYLKSQGKEMGPPFAIGVDSAQDWIKPGVIIASMMKRVDVGVYKAVEMVVKGKWKGGIMELGLADGGVGLSTIDDVKAMFNSLPEDVKKKKLEELGLKSEDELFAKLEQTRKQVPDWIWQAVDELKQKIISGEIVVPKAFNKEQIEAIRNAKTWQEMEELAKKWEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJV9</accession>
    <name>F0LJV9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466794.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00519"/>
    <dbReference type="EnsemblBacteria" id="ADT83496">
        <property type="protein sequence ID" value="ADT83496"/>
        <property type="gene ID" value="TERMP_00519"/>
    </dbReference>
    <dbReference type="GeneID" id="10040837"/>
    <dbReference type="KEGG" id="tba:TERMP_00519"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.519"/>
    <dbReference type="eggNOG" id="arCOG05823">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2550450_0_0_2"/>
    <dbReference type="OMA" id="PRPMIFE"/>
    <dbReference type="OrthoDB" id="129999at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="82" mass="9220" checksum="330390A4CF0583EC" modified="2011-05-03" version="1">MEPRPMILDDNPEIMPGGEDDVGEEAETVEQFFAKSQGNTLYFSYATTHAKITIGISHDSATLEEMVKAAKELINEFRKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJW7</accession>
    <name>F0LJW7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00527</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466802.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00527"/>
    <dbReference type="EnsemblBacteria" id="ADT83504">
        <property type="protein sequence ID" value="ADT83504"/>
        <property type="gene ID" value="TERMP_00527"/>
    </dbReference>
    <dbReference type="GeneID" id="10040845"/>
    <dbReference type="KEGG" id="tba:TERMP_00527"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.527"/>
    <dbReference type="eggNOG" id="arCOG04297">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_437379_0_0_2"/>
    <dbReference type="OMA" id="IAQMARY"/>
    <dbReference type="OrthoDB" id="17965at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="205"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="421"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="453"/>
            <end position="460"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="634" mass="73304" checksum="7ADCE4E07BA18D26" modified="2011-05-03" version="1">MILRGKVVGSEIPRFKHRWFGILEVETKGERYKLYMSGVAQWFVTGDEVEIHVKGKPKVKNGEKILDFDDYELYKFYQGDKIKVWPLWEREYEAKRYSPLTGELLYTYKIKAREATYESDFEAIAELEQYHYASQKEKVALWRCENGHVFESNTKQKCPVCGSEDVHILEIKGSTPASRFLILELENRKEYEPRILAYVRVDPPIPLMHRRLPNGEIEKNIREKVFPEDWFHPAFWPERIMKELYEELKKKYPKKVARSMLWEEAKWQALRESNTAGARIARVVVHPDYRSDGLGQLSVKAALEWIKERRIPEMRKRKHIVETIAQMARYNPFFEKVGFKFLWETASGRPVLFYPLSEEAKEYIERFLRDDPYAPKDGKLWRPSYGKVEPLKGSIVFKNVSKVFESELDIRGLPEEIQELLKAFGVRHRVIQRPVLRNLNFEIKPKELIVVVGASGAGKTTLLRLILGAAKGYWEEKYRPTGGEIEVPENVKVSVMIPGEFEPSFGSESILEHVYRKIRDLNAAVEVLNRSGLSDAVLYRAKFSELSTGQKERAKIASLLAEKPNLLLMDEFAAHLDTLTAMRVAKKVSEIIREAGITAVIITHRPEVVKALDPDKLLFVGYGTVRVSKGSAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJX5</accession>
    <name>F0LJX5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrogenase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466810.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00535"/>
    <dbReference type="MEROPS" id="A31.006"/>
    <dbReference type="EnsemblBacteria" id="ADT83512">
        <property type="protein sequence ID" value="ADT83512"/>
        <property type="gene ID" value="TERMP_00535"/>
    </dbReference>
    <dbReference type="GeneID" id="10040853"/>
    <dbReference type="KEGG" id="tba:TERMP_00535"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.536"/>
    <dbReference type="eggNOG" id="arCOG04429">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099037_1_0_2"/>
    <dbReference type="OMA" id="IRSAHFM"/>
    <dbReference type="OrthoDB" id="97767at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="149" mass="16662" checksum="6FD920DF950E8141" modified="2011-05-03" version="1">MRTLILALGNELMRDDGVGLKIGRILAEKGYNVLEVGTDIFKLQNYYNGEKRIVIVDAILSEKFEPGKIVHLKGEEVFEKLKAEIRSAHFMGAVDGLKLMMALDERLAKAEIHFIGIVAKEVELGMKLSKEVENAVPKVVELVEKIVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK22</accession>
    <name>F0LK22_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468031.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01759"/>
    <dbReference type="EnsemblBacteria" id="ADT84734">
        <property type="protein sequence ID" value="ADT84734"/>
        <property type="gene ID" value="TERMP_01759"/>
    </dbReference>
    <dbReference type="GeneID" id="10042075"/>
    <dbReference type="KEGG" id="tba:TERMP_01759"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1758"/>
    <dbReference type="eggNOG" id="arCOG05726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1297541_0_0_2"/>
    <dbReference type="OMA" id="RGHYRLN"/>
    <dbReference type="OrthoDB" id="99240at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="214" mass="24283" checksum="1BE0BF7A237D3BD9" modified="2011-05-03" version="1">MFFRPAGEEKRKVPLIEELSPLVGEVEEGSMVAVVTTDALSQTILQYSALANALNSGMTAYYLEPTNGFSLKLLNKLSENNENLFLGKVYTLDELSSALELVEDNSLVFVSNFSILENQSREKLIKMRRVVDEKSLFLVLSHNTLEINELDLNSEFKRLFVIPELFEHLLVLRTSGYRGHYRMNISVLKAPPEFVKNIGEHSIPIDKKAKMFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK42</accession>
    <name>F0LK42_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acylamino-acid-releasing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468050.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01779"/>
    <dbReference type="MEROPS" id="S09.071"/>
    <dbReference type="EnsemblBacteria" id="ADT84754">
        <property type="protein sequence ID" value="ADT84754"/>
        <property type="gene ID" value="TERMP_01779"/>
    </dbReference>
    <dbReference type="GeneID" id="10042095"/>
    <dbReference type="KEGG" id="tba:TERMP_01779"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1778"/>
    <dbReference type="eggNOG" id="arCOG01646">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_2_1_2"/>
    <dbReference type="OMA" id="YEMQLMA"/>
    <dbReference type="OrthoDB" id="3754at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="402"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="632" mass="73987" checksum="BEC0BABFC6504F8C" modified="2011-05-03" version="1">MSKIEWNEKTFAKFSYLGDVRISKDGKQIAYVLTKANLKDNKYENTIVIEDKSGVRKFIENASMPRFSPSGTKMSFVRPNEEKKTSELWLIDLRSMSAKKLMETKNILNVSWSSDDRRLLITGFKRREDEDFIFEDDVPVWFDNKGFFDGEKTTFWIYDTEGEEILDEFTADKFSSGIWHGEEIIYNVPHREDNKPQFFKFYDIYRYKDGESEKIFEKVSFTAIDSNGKEVLLIGKPKKEKLSEHDYLYLWNGREIRSLTERFVYNNWDGKLDAEGNVYFLSPREGRVSLYKLSEDELIPIVDENAWVMGFDVSNDGKVVLLKQTDTKLSEVFLWDGELKQITDYNGPILAKLKTRPIKHFRFKSLDLELDGWYIKPDIKEGEKAPVIVFVHGGPKGMYGYYFKYEMQLMADKGYYIVFVNPRGSNGYDEDFALRVLERTGLEDFQDIMNGIEEFFKLEPQADRGRVGITGISYGGFMTNWALTQSDLFKAGISENGISYWLTSYAFSDIGLWFDKEVIGDNPLENENYKKLSPLFYAQNVKAPILIIHSLEDYRCPLDQSVMFYHVLKDLGKEAYIAIFRKGAHGHSIRGSPRHRAKRYKLFMEFFERKLKRYEEGFDVEKILKEEKKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK50</accession>
    <name>F0LK50_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoate-protein ligase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468058.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01787"/>
    <dbReference type="EnsemblBacteria" id="ADT84762">
        <property type="protein sequence ID" value="ADT84762"/>
        <property type="gene ID" value="TERMP_01787"/>
    </dbReference>
    <dbReference type="GeneID" id="10042103"/>
    <dbReference type="KEGG" id="tba:TERMP_01787"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1786"/>
    <dbReference type="eggNOG" id="arCOG01939">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_5_0_2"/>
    <dbReference type="OMA" id="YAYLDDW"/>
    <dbReference type="OrthoDB" id="47035at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="28"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="249" mass="28616" checksum="2EA4BE74572CF426" modified="2011-05-03" version="1">MRFIPLIIARPEVQMAIDEAILKARIEGKVEDTVRLYVFKPSSITIGRFQSIEHDVNLRKCQELNIPVVRRITGGGSVFHDAYGEITYSVVLGEEFHPDLKDIHKSYRLIASPLIEALKELDIRAEFSGLNDIIANGKKISGSAQTRRKGVILQHGTFMYATRLDILASVLKVSKKKLADKGVKSIWERVTTVEREGIKLSRNDAYELLREKFFEEFPLEEGELTDYELELAEKLIEERYGRDEWNFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK87</accession>
    <name>F0LK87_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin converting factor, subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468095.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01824"/>
    <dbReference type="EnsemblBacteria" id="ADT84799">
        <property type="protein sequence ID" value="ADT84799"/>
        <property type="gene ID" value="TERMP_01824"/>
    </dbReference>
    <dbReference type="GeneID" id="10042140"/>
    <dbReference type="KEGG" id="tba:TERMP_01824"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1823"/>
    <dbReference type="eggNOG" id="arCOG00534">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089568_1_2_2"/>
    <dbReference type="OMA" id="WPLQRVS"/>
    <dbReference type="OrthoDB" id="62565at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="144" mass="16729" checksum="A7C333A05D5368E7" modified="2011-05-03" version="1">MLAKLFKKPEDFEVNKAIELVSSRKAGGIAIFLGKVREESHGRKVKKLIYEAYEDMALKEMEKIRKEAKEKFPIEEILIWHRYGELEVGENTILIVAAGKHRREAFEACMWAVNEVKKRVPIWKREVTDEGEFWIEGDKIIPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK93</accession>
    <name>F0LK93_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468101.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01830"/>
    <dbReference type="EnsemblBacteria" id="ADT84805">
        <property type="protein sequence ID" value="ADT84805"/>
        <property type="gene ID" value="TERMP_01830"/>
    </dbReference>
    <dbReference type="GeneID" id="26137344"/>
    <dbReference type="KEGG" id="tba:TERMP_01830"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1829"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OMA" id="IMECHMV"/>
    <dbReference type="OrthoDB" id="97695at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="150" mass="16875" checksum="C38124C5CA928BAF" modified="2011-05-03" version="1">MGEVLDKIDLKLLEELKKNARENIAALSKKLGIPRTTVHYRIKKLVEEGVIEKFTIKPNYKKLNLGTTAFILARYDPDSGLTQREVAERVATINGVYEVHIIAGEWDLLIKVRAASAEDIGKIVIDKLREIKGIDQTVTMVSFVTVKEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKA6</accession>
    <name>F0LKA6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">moaC</name>
        <name evidence="5" type="ordered locus">TERMP_00587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MoaC family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466862.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00587"/>
    <dbReference type="EnsemblBacteria" id="ADT83564">
        <property type="protein sequence ID" value="ADT83564"/>
        <property type="gene ID" value="TERMP_00587"/>
    </dbReference>
    <dbReference type="GeneID" id="10040905"/>
    <dbReference type="KEGG" id="tba:TERMP_00587"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.588"/>
    <dbReference type="eggNOG" id="arCOG01530">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074693_1_2_2"/>
    <dbReference type="OMA" id="IWDMVKS"/>
    <dbReference type="OrthoDB" id="104538at2157"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01419">
        <property type="entry name" value="MoaC_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_A">
        <property type="entry name" value="MoaC_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023047">
        <property type="entry name" value="Mo_CF_biosynth-C_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="4">
        <location>
            <begin position="13"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="109"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="156" mass="17487" checksum="CB1319F07AA380C8" modified="2011-05-03" version="1">MKLTHVDEKGVKMVEVGHKDVVFRKAIAKGKIRLKPETIKLIQEGKTKKGNVLAAAQIAGILAVKRTWEIIPLCHPIPLTGVDISFEFGEDYIEATCEVRAYYKTGVEMEALTGVSVALLTIWDMVKAVEKDEKGQYPVTRIYDIRVVEKIKGNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKC2</accession>
    <name>F0LKC2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps10</name>
        <name evidence="6" type="ordered locus">TERMP_00603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466878.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00603"/>
    <dbReference type="EnsemblBacteria" id="ADT83580">
        <property type="protein sequence ID" value="ADT83580"/>
        <property type="gene ID" value="TERMP_00603"/>
    </dbReference>
    <dbReference type="GeneID" id="26135856"/>
    <dbReference type="KEGG" id="tba:TERMP_00603"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.604"/>
    <dbReference type="eggNOG" id="arCOG01758">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_0_1_2"/>
    <dbReference type="OMA" id="QFEIRVH"/>
    <dbReference type="OrthoDB" id="107993at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_S10_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="102" mass="11710" checksum="6CEEF2D7D9E9E2D4" modified="2011-05-03" version="1">MQKARIKLASTNIKSLNEVADQIKQIAERTGVRMSGPIPLPTKRIRITTRKSPDGEGTATFDRFELRVHKRLIDIEADERAMRQIMRIRVPEDVTIEIELIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKD7</accession>
    <name>F0LKD7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|391623.17.peg.620"/>
    <dbReference type="eggNOG" id="arCOG01211">
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="NT_sf"/>
    </dbReference>
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        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="222" mass="26211" checksum="B591FE32060E8EBF" modified="2011-05-03" version="1">MEFLECIKKRIIQDDELKNELYSLILYGSFVRGDFLENVSDLDFFAVIIKDESIIPKLRQVLEDCTKEINAVEVDLAWEYLENISDPLRRGVPFKFLTIYQEDFLENHIVVYGKDIANILPKYKFENLLSWRIERILKLIERSKRNPKLMHILAGETARLLALINGAKSLRKKDIVNALEKIRDEEALEVYRAYLNGRKLKFDEGFLTRFIEARIDRIKKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKN2</accession>
    <name>F0LKN2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N6-adenine-specific RNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01891"/>
    <dbReference type="EnsemblBacteria" id="ADT84866">
        <property type="protein sequence ID" value="ADT84866"/>
        <property type="gene ID" value="TERMP_01891"/>
    </dbReference>
    <dbReference type="GeneID" id="10042207"/>
    <dbReference type="KEGG" id="tba:TERMP_01891"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000007478">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="69"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="365" mass="41266" checksum="4F5EEB42ECD47A97" modified="2011-05-03" version="1">MKFLLTTSQGIEDLAKKEVERLFESKGIKVSIEEKPFGVEGRLIAEVEESFYTDEKGKKREFSPATFLNENSRLLHRVIVEIASLKFKGIESQEPEKALREIYDFVYSLPIENYVKITESFAVRSFRKGEHEFTSVDIAKTVGSAIYDRLSRYGKPKVNLDHPSVIFRAELIDDVFFLGIDTTGDSSLHKRPWRVYDHPAHLKASIANAMTELAEVDGGSVIDPMCGSGTILIELALRGYEGRIIGIEKYKKHLRGARMNALAAGVLDRIEFIQGDATKLTQYADSVDFAISNLPYGLKIGKKSLIPKLYMEFFSELSKVLEKRGVFLTTEKKAIEEAFEENGFKILHHRLVGHGGLRVHLYVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKP6</accession>
    <name>F0LKP6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4129 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01905"/>
    <dbReference type="EnsemblBacteria" id="ADT84880">
        <property type="protein sequence ID" value="ADT84880"/>
        <property type="gene ID" value="TERMP_01905"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01905"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1904"/>
    <dbReference type="eggNOG" id="arCOG05832">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084679_0_0_2"/>
    <dbReference type="OMA" id="THWEHAR"/>
    <dbReference type="OrthoDB" id="73088at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="2">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="264" mass="30416" checksum="BE6210B884CA2487" modified="2011-05-03" version="1">MALIMSGQAKIEEIPKGSQNYYWVGLFFGIIVIAAGFIIIQILLSWQDLPTKRRNEGINQQIIVAIFAGTLMLSLPLLYMAYKAQLSPMVANNTTTQGVYVVNGSYHVTYYEKYFRNPVFQESSNVGVILYGVFGVVSATLVYLSMVFYKDLSAKRKIKKLKKEVQEFDKRLKEEGISFIGDPKDIVVKLYKNAVIWLEILGIPYRESWTHWEHAKRVRYKHDAYVELARLFEKAKYAPEKVTMEDAKRAYELYLIIKGEGHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKU0</accession>
    <name>F0LKU0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466967.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00692"/>
    <dbReference type="EnsemblBacteria" id="ADT83669">
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        <property type="gene ID" value="TERMP_00692"/>
    </dbReference>
    <dbReference type="GeneID" id="10041010"/>
    <dbReference type="KEGG" id="tba:TERMP_00692"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.693"/>
    <dbReference type="eggNOG" id="arCOG03827">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1006935_0_0_2"/>
    <dbReference type="OMA" id="RRIKNDY"/>
    <dbReference type="OrthoDB" id="79488at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="268" mass="30998" checksum="FC8BD7394283CE23" modified="2011-05-03" version="1">MVPKLNKFRKHLGKLTKGEKDDAIFGLVEAALKREDINAAISEVRRIKNDYYLFLGVRSIVKKIVQLAKKSINKFGSVLKHEKEAFREYLKELVILANSITEERLRAIVFADIAIAFYLIDESLEGDLALRTSLDLAEKLKDDDVTFEIVYSLVENDLLEKAAYAMNLVRNRKKLDVILSYMALHLYKEGREDDAAKVITHIQSDFHKVMALWKMAEFESKRDKKKAEEILKKAMELLKDIENPVLRFEAFVKIAELQEELAGRFRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKU5</accession>
    <name>F0LKU5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466972.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00697"/>
    <dbReference type="EnsemblBacteria" id="ADT83674">
        <property type="protein sequence ID" value="ADT83674"/>
        <property type="gene ID" value="TERMP_00697"/>
    </dbReference>
    <dbReference type="GeneID" id="10042545"/>
    <dbReference type="KEGG" id="tba:TERMP_00697"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.698"/>
    <dbReference type="eggNOG" id="arCOG00601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035203_0_0_2"/>
    <dbReference type="OMA" id="ETWGAIQ"/>
    <dbReference type="OrthoDB" id="45411at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014651">
        <property type="entry name" value="UCP036983_2CBS_MJ1404"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036983">
        <property type="entry name" value="UCP_2CBS_MJ1404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="136"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="214"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="392" mass="44646" checksum="F8D381A826267AB8" modified="2011-05-03" version="1">MVGILVEEVMTDKFAKIDVNAPLSEAIGIFEKEDPDLILVFDRSTYKGVVTQDLIIKSHLKWDPTKAKVKDVYKPAPVIKPRDDLSHAAKLMIETDLRSLPVGEDKTNIFGVISDLAILDRVIKEEFGKRKVKEFMTTDVITLKPDDTVAKALATMRDHAISRIPIVNEEGKLEGLVTLHDLIIRFIKPRFKAQYGELVGEKIPPFSTQLREVMIRGVITILPDATIREAVATMIDNRIDGLVVVNEENKVVGILTVKDLLLPISRMVEKEAKFYLQLGGDAHILSDFTRERIISDIKKFVDGYADVLGDEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFVATGETWGAIQAVHDALRAIERQILQKVELQRDLRYAKRFLDKLELWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKX2</accession>
    <name>F0LKX2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466999.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00724"/>
    <dbReference type="EnsemblBacteria" id="ADT83701">
        <property type="protein sequence ID" value="ADT83701"/>
        <property type="gene ID" value="TERMP_00724"/>
    </dbReference>
    <dbReference type="GeneID" id="10041042"/>
    <dbReference type="KEGG" id="tba:TERMP_00724"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.726"/>
    <dbReference type="eggNOG" id="arCOG01130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_2"/>
    <dbReference type="OMA" id="IHMEVGQ"/>
    <dbReference type="OrthoDB" id="32104at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="389" mass="43824" checksum="0D623B6C1376FAC3" modified="2011-05-03" version="1">MALSDVLERVNPSEIRKLFDLAQGIEGIISLGIGEPDFDTPEHIKEYAKEALDKGLTHYSPNAGISELREAVAEKLKRDNGIDADPKTQIMITVGANQALLMGFATFLKDGDEVLVPSPMFVSYAPAVILAGGKPVEVPTYEENEFRLNVDELERYVTSKTRALILNSPNNPTGSVLTKKDLEEIADFAVEHDLIILSDEVYEYFVYDGVRNHSIASLDGMFERTITINGFSKTFAMTGWRLGFVAAPEWIIEKMVRFQMYNATCPVTFVQYAAAKALRDERSWRAVEEMRREYDRRRQMVWKRLNEMGLPTVKPKGAFYIFPRIKDAGLTSKEFSELMIKEAKVVVVPGSAFGKAGEGYIRISYATAYEKLEEAMDRMEKVLKEKGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKX4</accession>
    <name>F0LKX4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proline--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="7">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proS</name>
        <name evidence="9" type="ordered locus">TERMP_00726</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467001.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00726"/>
    <dbReference type="EnsemblBacteria" id="ADT83703">
        <property type="protein sequence ID" value="ADT83703"/>
        <property type="gene ID" value="TERMP_00726"/>
    </dbReference>
    <dbReference type="GeneID" id="10041044"/>
    <dbReference type="KEGG" id="tba:TERMP_00726"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.728"/>
    <dbReference type="eggNOG" id="arCOG00402">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_4_2_2"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="14454at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="40"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="480" mass="55945" checksum="C2E2DDA48B434DC1" modified="2011-05-03" version="1">MKVERNKWQNNFSEWYNELIETAGIQDKRYPVKGMNIWLPYGLRIMRNIEKFIHEEMERTGHQEVLFPALIPETEFQKEAEHIAGFEGEVFWVTHAGHDPLDVRLILRPTSETAMYSMFALWIRSHADLPFKIYQIVNVYRYETKHTRPLIRVREISRFFEAHTAHDSFEDAERQIKEDLEIFDNLAKKLALPYIVSKRPEWDKFPGAYYSLGAEVVMPDGRTLQIGTMHNYKQNFAKAYNIMYEKEDGTHEYVHQTTYGMSERLLAAVIAVHGDDRGMVLPPTIAPIQVVIVPIPKKDSPYDVFAYAREIAEELKTAGIRVHVDERDIRPGRKFYDWELKGVPLRIEVGPRDVEGQKAVLARRDTLEKFTVERAELIEKVRETLDAIMDNLYARAKEFLDSHIKRVDTLEEAKEVFEDRRGVVEIPWCGEESCGLEMEEILDAKMLGIPYPEEEAKIEGKKCAHCGKDAKFIARFARTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKZ6</accession>
    <name>F0LKZ6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468199.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01928"/>
    <dbReference type="EnsemblBacteria" id="ADT84903">
        <property type="protein sequence ID" value="ADT84903"/>
        <property type="gene ID" value="TERMP_01928"/>
    </dbReference>
    <dbReference type="GeneID" id="10042244"/>
    <dbReference type="KEGG" id="tba:TERMP_01928"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1927"/>
    <dbReference type="eggNOG" id="arCOG00118">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_7_2_2"/>
    <dbReference type="OMA" id="IVNHGMY"/>
    <dbReference type="OrthoDB" id="37018at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="367" mass="40921" checksum="5E38E8EE66F2D2F6" modified="2011-05-03" version="1">MRQIPIAKPLIGDEEINAVVEVLKSGMLAYGDIVKAFEKEFAEYLGAKHGVATCNGTTALDVALKALKIKEGDEVITTPFTFIASANSILFQGAKPVFADIDPKTFNLDPNDVLEKINNKTRAILVVHLYGQPADIKVFKEIAEDYKLYLIEDCAQAHGAEFEGQKVGTFGDIAAFSFYPTKNMTTGEGGMIVTNDDELARRARLLINHGQTKKYYHEELGYNLRMTNIAATIGRVQLKKLDGWNAKRIENAKLLTEGISKIKGLTPPYVDPRVKHVFHQYVIRVEDDFPLNRDELAEKFRERGIGTGIHYPMPIHWQPLYQKLGYPKDCCPNAIEASKEVLSLPVHPAVSGEDIAYIIQTLKELSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL30</accession>
    <name>F0LL30_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468233.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01963"/>
    <dbReference type="EnsemblBacteria" id="ADT84937">
        <property type="protein sequence ID" value="ADT84937"/>
        <property type="gene ID" value="TERMP_01963"/>
    </dbReference>
    <dbReference type="GeneID" id="10042278"/>
    <dbReference type="KEGG" id="tba:TERMP_01963"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1961"/>
    <dbReference type="eggNOG" id="arCOG05775">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1954775_0_0_2"/>
    <dbReference type="OMA" id="EMRMEMF"/>
    <dbReference type="OrthoDB" id="102213at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="122" mass="14389" checksum="E155BBE6F769D9EC" modified="2011-05-03" version="1">MPAREMRMEMFLRALMRRDFNKAKSHLEKLEKMVGNDEWGRGYSKAINGFISALKDNDTDALIVQLVKEVDHEKAKQLLSHFKEILNQEFRDEYEKGYYTAWTELLTAYLSQKTLGVKRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL46</accession>
    <name>F0LL46_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468249.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01979"/>
    <dbReference type="EnsemblBacteria" id="ADT84953">
        <property type="protein sequence ID" value="ADT84953"/>
        <property type="gene ID" value="TERMP_01979"/>
    </dbReference>
    <dbReference type="GeneID" id="10042294"/>
    <dbReference type="KEGG" id="tba:TERMP_01979"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1976"/>
    <dbReference type="eggNOG" id="arCOG03792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102063_2_0_2"/>
    <dbReference type="OMA" id="RINPEVM"/>
    <dbReference type="OrthoDB" id="116351at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005489">
        <property type="entry name" value="DUF257"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03192">
        <property type="entry name" value="DUF257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="211" mass="23885" checksum="353803B897B7779B" modified="2011-05-03" version="1">MENDLDEIWDSIKFGETVLVEHSSLASPVKGLYHLIEWAKRKGYGVIVDDILDTLYLYRIHMKLAGYDESILDSITVIKEGGKVNVGSVVKRFPIEEPSVYEQEYGKIFSSVVKGKVINPVVGFEKLLFLANSKQDLLSMINITLSFCGNDKRIAFYFVNADMAERINPEVMPLLEEVATTVIRIIKEGTSHMFMVLKSVNENMEGMKVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL85</accession>
    <name>F0LL85_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467034.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00759"/>
    <dbReference type="EnsemblBacteria" id="ADT83736">
        <property type="protein sequence ID" value="ADT83736"/>
        <property type="gene ID" value="TERMP_00759"/>
    </dbReference>
    <dbReference type="GeneID" id="26136211"/>
    <dbReference type="KEGG" id="tba:TERMP_00759"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.761"/>
    <dbReference type="eggNOG" id="arCOG01700">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1168611_0_0_2"/>
    <dbReference type="OMA" id="DAHTDLM"/>
    <dbReference type="OrthoDB" id="72143at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="242" mass="27884" checksum="E50A8C9ACE3E9A8B" modified="2011-05-03" version="1">MVTFIPFGEKPNREGVMYVLNFLQKNKLIEDYMVVESNTIELLSERLPVDEAYIIGDHLATYGILQKLKPKAVISIDAHTDLMHDYLDHGSWLAYALSERIIEKASIIGPVLMIPTTEGTELWTRRVKIFPALPRSRKTRGKWKAYKSLKNHPIDEIIKDTKKYLGEEIYLTIDLDVLLPDYKIARFQHGELTLEELLNILEEIKRNFNIVAFDIAEISDKIKRSRLGKKALADVFQLLSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLC5</accession>
    <name>F0LLC5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467074.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00799"/>
    <dbReference type="EnsemblBacteria" id="ADT83776">
        <property type="protein sequence ID" value="ADT83776"/>
        <property type="gene ID" value="TERMP_00799"/>
    </dbReference>
    <dbReference type="GeneID" id="10041117"/>
    <dbReference type="KEGG" id="tba:TERMP_00799"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.801"/>
    <dbReference type="eggNOG" id="arCOG09827">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176751_0_0_2"/>
    <dbReference type="OrthoDB" id="126939at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="79" mass="9288" checksum="1F864C37A25E0FB3" modified="2011-05-03" version="1">MVLSFFRLLFLIPKLLWNLAGIKRTIRKSKRKFKRVLVKSGVPKELAEELANEYALPDDIISLKALVKIPKYLKYTRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLG4</accession>
    <name>F0LLG4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="9">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA wyosine derivatives biosynthesis protein Taw1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">taw1</name>
        <name evidence="11" type="ordered locus">TERMP_02019</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02019"/>
    <dbReference type="EnsemblBacteria" id="ADT84993">
        <property type="protein sequence ID" value="ADT84993"/>
        <property type="gene ID" value="TERMP_02019"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02019"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2016"/>
    <dbReference type="eggNOG" id="arCOG04174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007952_3_0_2"/>
    <dbReference type="OMA" id="HRCLQMT"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01921">
        <property type="entry name" value="TYW1_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023993">
        <property type="entry name" value="TYW1_archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="PTHR13930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03972">
        <property type="entry name" value="rSAM_TYW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="52"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT84993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="326" mass="37976" checksum="3AF620D51210E511" modified="2011-05-03" version="1">MENVKPNMPEEIARLFKKQHYALVGRHSGVKLCHWLKESIKHNRVCYKQKFYGIHSHRCLQMTPVLAWCTHNCVFCWRPMEGFLGTELPKPWDDPAFIVEESIKAQRKLLSGFGGIKDRINVKKYEEAQEPKHAAISLSGEPTLYPYIGDLVEEFHKRGFTTFIVTNGTVPEAIEQMKKEGKLPTQLYVSLTAPDIETYNRVNIPMIPDGWERIIKTLELMRDLPTRTVIRLTLVKGENMHNPKGYAELIMKAKPMFVEAKAYMFVGFSRNRLTINNMPKHEEIKAFAEELVKYLPGYHIEDEYQPSRVVLIMRDDISKEERFIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLG5</accession>
    <name>F0LLG5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468290.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02020"/>
    <dbReference type="EnsemblBacteria" id="ADT84994">
        <property type="protein sequence ID" value="ADT84994"/>
        <property type="gene ID" value="TERMP_02020"/>
    </dbReference>
    <dbReference type="GeneID" id="10042335"/>
    <dbReference type="KEGG" id="tba:TERMP_02020"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2017"/>
    <dbReference type="eggNOG" id="arCOG03396">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372862_0_0_2"/>
    <dbReference type="OMA" id="NGWGYIP"/>
    <dbReference type="OrthoDB" id="21164at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="PTHR11764"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="751" mass="84947" checksum="07298F4398622DEB" modified="2011-05-03" version="1">MKKRALSLMLVIFIITSYGLVGAKPILDGSVEFLTKTKNLANTTQEISLVLLALTSAQGKVDYNLIENITYIANILVSWQNPDGGWGYFKGSVSNVVDTSYAVIALSKVLHLYEKGTPEYSKIFHALDDGISFLLSSYSGSGWGYVPKTEPEFYPTVMAIWALGENGFRVDHPYIKRSLSYIANVEEYGIDKYKALALELLAFKSVGKDIDTNLVGEIKKALESENLSVSDRALLTYALVDYEDVNFDVAKALLILESLKKGQSTFYWSDEPKLFSQAHLFEASSYAALSFALISDKLSQGLENPFKTSCEALKSAQNPDGGWSYYYGFPSNEKATYYTLKALKLCYFRDPSIEKGLKWVRAKYEEDKLIARKNKEIYSPYVYALLTLLEFNMLNETEKDENIKLIESIQLDTGKWGDFLGPQPYDTALAIKALLALGVPSNSTEIQRAKNWLLSISKTGWGTYVDTGFYSYMLPPEVSVTLEVLEALAPISTKDELEPHLKWLLEQRTEDGGWANIREHYLIGVFQYKEKPTIELTIRAAELLAEFGYDYREDVLNWLMDKKHGGLWGDTVVDSALATQFLSQFKFIPKINLYDVIRLIPEQKFYVVYTDDRNLTAQQIKASIDKLFETNTTVEKFQGFGDANYIVLSDFGEFNIKDYNPYVKLEVDNETIHINGEEYSIKNTVVLIPGKTETGYILFVFYEKGLDDVVAKIFDSGLVKYLKGDALVVTYKDKNHDGVVDLDELTVKFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLH0</accession>
    <name>F0LLH0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02025"/>
    <dbReference type="EnsemblBacteria" id="ADT84999">
        <property type="protein sequence ID" value="ADT84999"/>
        <property type="gene ID" value="TERMP_02025"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02025"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2022"/>
    <dbReference type="eggNOG" id="arCOG05789">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2313929_0_0_2"/>
    <dbReference type="OMA" id="QITENPH"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="99" mass="10741" checksum="DAC34B742FC18DBC" modified="2011-05-03" version="1">MGVLTDDPRYSPLNSALETLNGLNPNLRVLKIETSQINDTITITVVLTTPYSAINNETLASAVENFIVRDLNMTTNLILSNGTLFYGDTAVNIAVRVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLI8</accession>
    <name>F0LLI8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit PurQ</fullName>
            <shortName evidence="1">FGAM synthase</shortName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formylglycinamide ribonucleotide amidotransferase subunit I</fullName>
            <shortName evidence="1">FGAR amidotransferase I</shortName>
            <shortName evidence="1">FGAR-AT I</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutaminase PurQ</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purQ</name>
        <name evidence="2" type="ordered locus">TERMP_02043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468313.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02043"/>
    <dbReference type="EnsemblBacteria" id="ADT85017">
        <property type="protein sequence ID" value="ADT85017"/>
        <property type="gene ID" value="TERMP_02043"/>
    </dbReference>
    <dbReference type="GeneID" id="10042358"/>
    <dbReference type="KEGG" id="tba:TERMP_02043"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2040"/>
    <dbReference type="eggNOG" id="arCOG00102">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_3_1_2"/>
    <dbReference type="OMA" id="LHFVCRD"/>
    <dbReference type="OrthoDB" id="90817at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00421">
        <property type="entry name" value="PurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01737">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="223" mass="24798" checksum="C307528D015A3CE0" modified="2011-05-03" version="1">MPKFAVIVFPGTNCDFETAEAIKKAGGKAERVWYKESLKDFDGVVLPGGFSYADYLRAGAISARAEIMEEVKELAKDGKPVLGICNGFQILTEAKLLSGALRPNKIPRFLCRWVYLRVADTETAFTGFYKEGEVIRMPIAHAEGNYYTNDLSKVRIVFQYSDENGNINEEANPNGSILNIAGISNEKGNVLGMMPHPERASDRWLGSEDGLRVFKSMVEYAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLK3</accession>
    <name>F0LLK3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfate adenylate transferase</fullName>
            <shortName evidence="7">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sat</name>
        <name evidence="10" type="ordered locus">TERMP_02058</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468328.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02058"/>
    <dbReference type="EnsemblBacteria" id="ADT85032">
        <property type="protein sequence ID" value="ADT85032"/>
        <property type="gene ID" value="TERMP_02058"/>
    </dbReference>
    <dbReference type="GeneID" id="10042373"/>
    <dbReference type="KEGG" id="tba:TERMP_02058"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2055"/>
    <dbReference type="eggNOG" id="arCOG04191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022950_1_1_2"/>
    <dbReference type="OMA" id="LQHMIIR"/>
    <dbReference type="OrthoDB" id="15586at2157"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00066">
        <property type="entry name" value="Sulf_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020792">
        <property type="entry name" value="SO4_adenylyltransferase_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_2" evidence="9">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase" evidence="8">
        <location>
            <begin position="164"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT85032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="379" mass="43789" checksum="9BFB7DA2FE51E459" modified="2011-05-03" version="1">MVSKPHGGKLVRRIAAPKTRERIIGEQREYPKAEVDHGRAIDLENIAHGIYSPLKGFLTSDDFQSVLDHMRLSDDTPWTIPIVLDVEKPEFEEGDAILLYYDDLPIARMHVEEIYTYDKKEFAQKVFKTTDPNHPGVAKVYGMGKYLVGGEIELLNELPNPFAKYTLRPVETRVLFKERGWKTIVAFQTRNVPHMGHEYVQKAALTFVDGLFINPVLGKKKRGDYRDEVIIKAYEVLFKHYYPRDAATLATVRYEMRYAGPREAIHHAIMRKNFGATHFIVGRDHAGVGDYYGPYEAWDLFDEFPDLGITPMFIREAFYCKRCGGMVNAKICPHSEEFHVRISGTKLRKMIMSGEKPPEYMMRPEVYEVIRSFENPFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLN1</accession>
    <name>F0LLN1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00831</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467106.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00831"/>
    <dbReference type="EnsemblBacteria" id="ADT83808">
        <property type="protein sequence ID" value="ADT83808"/>
        <property type="gene ID" value="TERMP_00831"/>
    </dbReference>
    <dbReference type="GeneID" id="10041149"/>
    <dbReference type="KEGG" id="tba:TERMP_00831"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.833"/>
    <dbReference type="eggNOG" id="arCOG05661">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166571_0_0_2"/>
    <dbReference type="OMA" id="IGDWIFF"/>
    <dbReference type="OrthoDB" id="114008at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="83" mass="9365" checksum="75CFD7CD8D383313" modified="2011-05-03" version="1">MVGGEIIGLMGMLLLVSSWVPQTIETIRTKQCPLNFRFILIYVTASTLLTIYSYIIGDWIFLMLNALAAFQSAVNLYVKVRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLN7</accession>
    <name>F0LLN7_THEBM</name>
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        <submittedName>
            <fullName evidence="7">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ordered locus">TERMP_00837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467112.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00837"/>
    <dbReference type="EnsemblBacteria" id="ADT83814">
        <property type="protein sequence ID" value="ADT83814"/>
        <property type="gene ID" value="TERMP_00837"/>
    </dbReference>
    <dbReference type="GeneID" id="10041155"/>
    <dbReference type="KEGG" id="tba:TERMP_00837"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.840"/>
    <dbReference type="eggNOG" id="arCOG01954">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_2"/>
    <dbReference type="OMA" id="TVRVMMD"/>
    <dbReference type="OrthoDB" id="79669at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="9"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="418" mass="45468" checksum="6BE2D37AA05AF3C5" modified="2011-05-03" version="1">MEPEWILFTIGVALIVGKIGDNIMERFELPGVLGEILMGMILGNLIYFGVISPEYLTLHSNETFEFLAKLGIIFLLFLGGLDTDMEMIKRTGKVATVSTLMGVFAPLIMGYFGLKLMGYPSREAFAGGVLLTATSIGITVRVMMDLGVLRSEVGAASLSASVMDDFLGIALIIFAVGTGSILGLIGKMTAFFIITGVVAWYSIDKYIRFSEWLHVEKGVLAMVLALMFLFSALAEKWFAAAIEGAFMAGLVLSKLPEGRKIAEDVKAIGYGFLIPIFFVYTGAMLDLKVFMSRDALALAAVLTSIAVIGKVVGRGIGAMMMGWNFKKSLQMGIGSIPRTEVALVDLMVAIHGGAIPQSDAQKFIAATLIFITVSVLITPPLLKWAFKEDVEKMKKEKAEIRKEKVKETKRKIAEIRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLP6</accession>
    <name>F0LLP6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467121.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00846"/>
    <dbReference type="EnsemblBacteria" id="ADT83823">
        <property type="protein sequence ID" value="ADT83823"/>
        <property type="gene ID" value="TERMP_00846"/>
    </dbReference>
    <dbReference type="GeneID" id="10041164"/>
    <dbReference type="KEGG" id="tba:TERMP_00846"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.849"/>
    <dbReference type="eggNOG" id="arCOG01472">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026706_1_0_2"/>
    <dbReference type="OMA" id="LCHPPKS"/>
    <dbReference type="OrthoDB" id="28706at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007380">
        <property type="entry name" value="DUF438"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04282">
        <property type="entry name" value="DUF438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF438" evidence="2">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="94"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="445" mass="51840" checksum="A38A833899F59281" modified="2011-05-03" version="1">MTELLKNREYKKEKMKELLKKIHSGEDVEKLKEEFKELLRSISPLEIPLIEQELVKEGISARDIAKMCDIHVELFREAVAGVEKEEIKDIPPGHPLHTLYEENREIMKDAEMLNLYASTLANTKDEKMRQEILGVLKGIANQLRAVGFTHYNREEMLIFPYLERRGITAVPTVLWTKHDEIRAMIKQLIEILNRENEMEWEQFVSKVKEKASELSRALVDMVFRENNILYPTLKALLSEGEWVAIKQQEEAIGYYKVKPGDEWKPRAKPLHPYEIDPTLTAEQILSLPKEVQMALRGQKLEGDRTKVKREGDLELDTGYLSPKEINAIFKHLPVDITFIDKDDRVRFFSGGDRIFTRTPSVIGRPVQLCHPPKSVHVVNKILRAFKEGKKDVAEFWIQMGGRFIHIRYFAVRDENGEYLGTLEVVQDVTEIRKLEGEKRLLDWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLS7</accession>
    <name>F0LLS7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467152.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00877"/>
    <dbReference type="EnsemblBacteria" id="ADT83854">
        <property type="protein sequence ID" value="ADT83854"/>
        <property type="gene ID" value="TERMP_00877"/>
    </dbReference>
    <dbReference type="GeneID" id="10041195"/>
    <dbReference type="KEGG" id="tba:TERMP_00877"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.880"/>
    <dbReference type="eggNOG" id="arCOG05132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188854_0_0_2"/>
    <dbReference type="OMA" id="LKWMAMN"/>
    <dbReference type="OrthoDB" id="131134at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010001">
        <property type="entry name" value="BofA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07441">
        <property type="entry name" value="BofA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="78" mass="8574" checksum="895749465BD2EC9C" modified="2011-05-03" version="1">MFQWLIFLVLLILAGYLVLKLTLAILKWMAMNTIIGLILVGIINFLGIAHIELNLVNLLIIAVGGVVGVFILLVLSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLV9</accession>
    <name>F0LLV9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_02084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468354.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02084"/>
    <dbReference type="EnsemblBacteria" id="ADT85058">
        <property type="protein sequence ID" value="ADT85058"/>
        <property type="gene ID" value="TERMP_02084"/>
    </dbReference>
    <dbReference type="GeneID" id="10042399"/>
    <dbReference type="KEGG" id="tba:TERMP_02084"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2081"/>
    <dbReference type="eggNOG" id="arCOG04188">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090940_1_1_2"/>
    <dbReference type="OMA" id="RGVFLEW"/>
    <dbReference type="OrthoDB" id="96034at2157"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT85058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="185" mass="21575" checksum="4B14D7EC2C7F1541" modified="2011-05-03" version="1">MPFEFKRLEIPDVILIKPKVFEDERGFFMETYKKPDFEKAGIKGEFVQDNHSKSKYGVLRGLHFQKEPYAQAKIVRCIRGVIYDVAVDLRKNSPTFGKYVGVILSEYNKYMLYIPRGFAHGFVVLSDVAEVVYKVDNVYAPDYEGGLIWNDPDVNIQWPVENPVVSEKDKRWPTLKELIEKDELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLY6</accession>
    <name>F0LLY6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468381.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02111"/>
    <dbReference type="EnsemblBacteria" id="ADT85085">
        <property type="protein sequence ID" value="ADT85085"/>
        <property type="gene ID" value="TERMP_02111"/>
    </dbReference>
    <dbReference type="GeneID" id="10042426"/>
    <dbReference type="KEGG" id="tba:TERMP_02111"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2108"/>
    <dbReference type="eggNOG" id="arCOG02225">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_0_0_2"/>
    <dbReference type="OMA" id="CEMEREY"/>
    <dbReference type="OrthoDB" id="99890at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="134" mass="15369" checksum="5C7708230D6B7609" modified="2011-05-03" version="1">MGKGYLIDTNILIYYLADAIPEGEINKVEDILKTSFNVSIITKIEFLGWRGHTDEGFKKAEEFISFARVIPLTDEIANLTIDLRRKYKIKLPDAVIAATALYHDLILVTRNEKDFWGIKGLEIYNPFKNYEGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM21</accession>
    <name>F0LM21_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase_M50 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00891</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467166.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00891"/>
    <dbReference type="MEROPS" id="M50.A04"/>
    <dbReference type="EnsemblBacteria" id="ADT83868">
        <property type="protein sequence ID" value="ADT83868"/>
        <property type="gene ID" value="TERMP_00891"/>
    </dbReference>
    <dbReference type="GeneID" id="26136336"/>
    <dbReference type="KEGG" id="tba:TERMP_00891"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.893"/>
    <dbReference type="eggNOG" id="arCOG00609">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03770">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028221_0_1_2"/>
    <dbReference type="OMA" id="AGWVGIL"/>
    <dbReference type="OrthoDB" id="89203at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044838">
        <property type="entry name" value="EGY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412">
        <property type="entry name" value="PTHR31412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="6">
        <location>
            <begin position="297"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="409" mass="44593" checksum="9D268BA54C211CF6" modified="2011-05-03" version="1">MPKGIYECIDCGYREVRESTEPLLERSCPNCGGDMVLVGFTEEIEAVEEPISQKLIQEIKKFYDIGGVLRQEANLLAFEVLSIKEENFEVVLRELESLGYWAALKRRGGKIVLYVFPAQHVKSENPLIGILLFVATLISTFGAGYLLSLGYVQALDQYNLPGIRNIYLNALAFSISIMAILGTHEMGHKIAATLHGVKSTFPYFIPFPSFIGTMGAVIRVKSPIPTRNAAIDLGVSGPLAGFLVALPVSIIGLKLSLVLPASIVNLKEGGIIFGTNLFFMILEKYFLHLGEGYVILFHPVAIAGWVGILVTFLNLVPAAQLDGGHIARAFLNEKMHAYLTFGLGFALIALSYLWVGWLIWGGIILLMGRIGNPGALDEVSPISFKRKILAVIALLIFVLSATPVPLSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM47</accession>
    <name>F0LM47_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TERMP_00918</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HerA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467192.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00918"/>
    <dbReference type="EnsemblBacteria" id="ADT83894">
        <property type="protein sequence ID" value="ADT83894"/>
        <property type="gene ID" value="TERMP_00918"/>
    </dbReference>
    <dbReference type="GeneID" id="10041235"/>
    <dbReference type="KEGG" id="tba:TERMP_00918"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.919"/>
    <dbReference type="eggNOG" id="arCOG00280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023842_2_0_2"/>
    <dbReference type="OMA" id="CLVSQRP"/>
    <dbReference type="OrthoDB" id="33242at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018538">
        <property type="entry name" value="HerA_barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033186">
        <property type="entry name" value="HerA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05872">
        <property type="entry name" value="DUF853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09378">
        <property type="entry name" value="HAS-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAS-barrel" evidence="11">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="DUF87" evidence="9">
        <location>
            <begin position="138"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="DUF853" evidence="10">
        <location>
            <begin position="423"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="363"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT83894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="577" mass="64986" checksum="2F1C740067E2AF39" modified="2011-05-03" version="1">MRVTEEVVGIVRGEATVTNYTFSAQPDAELRFGEFVVAQNREGEWVIGNIRKLENINWLLSGGKSTYHALQLDLEQYGDSIEANEELIATVRILGKIKVNGGKVEVLPNRVPIPNGRKVYRLSDEVLRAIYNPGVGYIEVGNLLLRESVPIYLNADELVSRHFAVLAVTGAGKSNTVAVMISQIVEKLRGTVVVLDPHGDYIKLKLPNTGKEYVKIIEAKIRPEEMDSEELADLIEVAKNATIQREFLAKAWETVKHDYPNLGGREIIEKLMETINDWIRHKEAKYWDGAKQSYLTEELKSERVDTLRGVVLRIRRFLRNYGALLTSEDLISQIEPGKANVIDLGPLDEGQMKVVVGKLLHAIFEARVDYEKARKKLERIKEELRESRVARTSKLDEEMKELEKTMKDIEAKSKALAEPILLIVEEAHIFAPQGEHNDAVRILSRIAREGRKFGVGLGIVSQRPNKLNEDVLSQTNTKIILRIVNPKDQDYVLKASEQLSSDLLSDIASLGKGEAVIVGQAIALPALVKIHNFKSKGGDYGGEDIGVVSRWLKRAEEEEREREIQQIYEDEGIEYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM51</accession>
    <name>F0LM51_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467196.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00922"/>
    <dbReference type="EnsemblBacteria" id="ADT83898">
        <property type="protein sequence ID" value="ADT83898"/>
        <property type="gene ID" value="TERMP_00922"/>
    </dbReference>
    <dbReference type="GeneID" id="25394630"/>
    <dbReference type="KEGG" id="tba:TERMP_00922"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.923"/>
    <dbReference type="eggNOG" id="arCOG03797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067022_1_0_2"/>
    <dbReference type="OMA" id="NPRRLEY"/>
    <dbReference type="OrthoDB" id="97271at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008553">
        <property type="entry name" value="DUF835"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05763">
        <property type="entry name" value="DUF835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF835" evidence="1">
        <location>
            <begin position="135"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="271" mass="30711" checksum="E4926C0B6445B086" modified="2011-05-03" version="1">MTILGALIAVAIEVALLIILAFSIKYRPVFIRHHPRLKKFYDYILLGFMVSTFAKLVFLPLDLGDMGLIVITSSERSMLNLLGNFFFIIGIFFIVLGWAHLIKTLTTKYILTPVVELGNGRVQVKVSPGLYICNIDKGYSAFLNLLKGRAGVIISRVPPEILRKRLNLEKTPILWLTKVEGGKTVHPHRLEFLLHTLVDFMKRDSTSKIILLDGLEYLVLENGFTPVFKFLTALKDHAVMNNTIIVVPIKMDAFDEKELSLLKREFGELNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM80</accession>
    <name>F0LM80_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome-activating nucleotidase</fullName>
            <shortName evidence="5">PAN</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Proteasomal ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Proteasome regulatory ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Proteasome regulatory particle</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pan</name>
        <name evidence="8" type="ordered locus">TERMP_00951</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467225.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00951"/>
    <dbReference type="EnsemblBacteria" id="ADT83927">
        <property type="protein sequence ID" value="ADT83927"/>
        <property type="gene ID" value="TERMP_00951"/>
    </dbReference>
    <dbReference type="GeneID" id="10041268"/>
    <dbReference type="KEGG" id="tba:TERMP_00951"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.954"/>
    <dbReference type="eggNOG" id="arCOG01306">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_2"/>
    <dbReference type="OMA" id="YNMTTFE"/>
    <dbReference type="OrthoDB" id="30571at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022623">
        <property type="term" value="C:proteasome-activating nucleotidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00553">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005937">
        <property type="entry name" value="26S_Psome_P45-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023501">
        <property type="entry name" value="Nucleotidase_PAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01242">
        <property type="entry name" value="26Sp45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="172"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="183"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="398" mass="45124" checksum="838C87A425AAB06F" modified="2011-05-03" version="1">MSDINDVVKSHDEYDDYIIYLKRRIRQLELQVRTLEADKERLERELSRLRMEMSRLRQPPAFAGTLLEILDDDRAIVQNYNGPRFVVRIAPWIEKEKLKPGSRVALDQRTMAVVEILPSPKDPSVLGFEVIDRPNVTYDDIGGLKKQLQELREAVELPLKHPELFEKVGIEPPKGVLLYGPPGCGKTLMAKALAREVNATFIRVVGSELVRKYIGEGARLVHELFELAKEKAPTIIFIDEIDAIGAKRLEETTGGEREVNRTLMQLLAELDGFDPRGNVKVIAATNRPDILDPALLRPGRFDRLIEVPLPDFAGRLEILKVHTRKMNLRNVDLRVIAEMTEGASGADLKAIATEAGMFAIRDRREYVTQEDFLKAVEKVFGSEQRLAQQIAMHEVMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM86</accession>
    <name>F0LM86_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_00957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467231.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00957"/>
    <dbReference type="MEROPS" id="M48.A10"/>
    <dbReference type="EnsemblBacteria" id="ADT83933">
        <property type="protein sequence ID" value="ADT83933"/>
        <property type="gene ID" value="TERMP_00957"/>
    </dbReference>
    <dbReference type="GeneID" id="26136406"/>
    <dbReference type="KEGG" id="tba:TERMP_00957"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.960"/>
    <dbReference type="eggNOG" id="arCOG01331">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042266_5_0_2"/>
    <dbReference type="OMA" id="WEDMPWL"/>
    <dbReference type="OrthoDB" id="62484at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="57"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="259" mass="29863" checksum="0FC6A4C008F42B06" modified="2011-05-03" version="1">MLRLIILAQILITVLYLGKFGLVVVFGSASMLLLMYLWVTRHSLKREHSKLKWEDMPWLYDGIARMANKAGIGMPYVYILDDYIPNAYSFGNSIVLSLGLFEVLDREQILGVAAHEIGHIKNGDTLIFPIIAYGRYFMLFLAGAISLIVHSTIAVLASLGLYMLYEIERLKFLKEREFKADETALYLLDRPFSLKEALEELKYYEDLRINVRASALPGIEPNIERKQKKSFMDTHPSYDERIWRILAEIEGAMFRDTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM91</accession>
    <name>F0LM91_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467236.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00962"/>
    <dbReference type="EnsemblBacteria" id="ADT83938">
        <property type="protein sequence ID" value="ADT83938"/>
        <property type="gene ID" value="TERMP_00962"/>
    </dbReference>
    <dbReference type="GeneID" id="10041279"/>
    <dbReference type="KEGG" id="tba:TERMP_00962"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.965"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_668386_0_0_2"/>
    <dbReference type="OMA" id="LCVGTHI"/>
    <dbReference type="OrthoDB" id="22281at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="27"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="410" mass="45232" checksum="8E8F978A8579597C" modified="2011-05-03" version="1">MKREKAVMQALRERVGKFNTKQKRRKNIVLFAIGMFLANVSWGMAFPYLSVYMRIIGGTMLFVGLLSVVFNITSTVFQYPFGYLSDRTQKRKPFIAFGVFSSGLIYVFMALVSSPILLLTLRAFQGALTSAMMPAHSALISELSTKVGSAFGFFSSVENAGYMLGNFLGSFIVEYFGIKGAFFVAFLFATLGTLFVLMISERVRPKKRDFGIIAVQEGRESDKVIFEGAAFRKFMRGNLRTFYISMLLVMIASGEVYSVLSVYFGELFGEKWVGVLFGIDSLAAAVSAVFIGRLIDRYGAKLFYVLSIAGYMAVFVGYIFATSLWLMVAICMVSGIKWSMTVSSASTYVALKVKTSEKAQAMGLLNAMMSLGWAIGPMLGGYLAGINFKLMFLSTLVPLSLALILAFKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM99</accession>
    <name>F0LM99_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468418.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02148"/>
    <dbReference type="EnsemblBacteria" id="ADT85122">
        <property type="protein sequence ID" value="ADT85122"/>
        <property type="gene ID" value="TERMP_02148"/>
    </dbReference>
    <dbReference type="GeneID" id="10042463"/>
    <dbReference type="KEGG" id="tba:TERMP_02148"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2145"/>
    <dbReference type="eggNOG" id="arCOG02078">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067052_1_1_2"/>
    <dbReference type="OMA" id="IACWPEL"/>
    <dbReference type="OrthoDB" id="67615at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002829">
        <property type="entry name" value="DUF116"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43801">
        <property type="entry name" value="PTHR43801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01976">
        <property type="entry name" value="DUF116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006594">
        <property type="entry name" value="UCP006594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="205" mass="22601" checksum="55B53ED16B87772B" modified="2011-05-03" version="1">MSLENTIAKLFALGADLSTRNAVRMALSLISEDEELTDQIYVELKNKAYKEDFAKIPAEKRAVFIPQCLRNIKECPAEFDSYGWKCTKCGKCVIGDIIEYGEKLGYRQFYITPGGSLVKKILKEKVPKGEIKAAIGIACWPELAEAAEKLAPLKIPLQAVPLLKAGCINTIVDIERVKDVLRIGIADGREKAELSASMVRKPAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMF5</accession>
    <name>F0LMF5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable molybdenum cofactor guanylyltransferase</fullName>
            <shortName evidence="4">MoCo guanylyltransferase</shortName>
            <ecNumber evidence="4">2.7.7.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GTP:molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Mo-MPT guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin-guanine dinucleotide synthase</fullName>
            <shortName evidence="4">MGD synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mobA</name>
        <name evidence="6" type="ordered locus">TERMP_02204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide</text>
            <dbReference type="Rhea" id="RHEA:34243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:71310"/>
            <dbReference type="EC" id="2.7.7.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MobA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.77" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468474.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02204"/>
    <dbReference type="EnsemblBacteria" id="ADT85178">
        <property type="protein sequence ID" value="ADT85178"/>
        <property type="gene ID" value="TERMP_02204"/>
    </dbReference>
    <dbReference type="GeneID" id="10042519"/>
    <dbReference type="KEGG" id="tba:TERMP_02204"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2199"/>
    <dbReference type="eggNOG" id="arCOG01872">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055597_2_2_2"/>
    <dbReference type="OMA" id="HENGYIE"/>
    <dbReference type="OrthoDB" id="78708at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061603">
        <property type="term" value="F:molybdenum cofactor guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00316">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="5">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="6"/>
            <end position="8"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT85178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="191" mass="21756" checksum="782786D2AFECC282" modified="2011-05-03" version="1">MIAAVLAGGKSRRFGDDKLLYKVDGKPIVMHTIERLLKAENIDDVVIVTCQEKKEDFEALGFRVLIDDLLVGPIGGIFVALKEVGDAFIAAGDLPLINPKFVDYIVERFYESKSLACIPMWANGYIEPLHAVYSKDFLPILKEQIKKGEYMIRKAVERVDPCYILIDDFPEEFKESFFNINTKHDLKRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMF7</accession>
    <name>F0LMF7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468476.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02206"/>
    <dbReference type="EnsemblBacteria" id="ADT85180">
        <property type="protein sequence ID" value="ADT85180"/>
        <property type="gene ID" value="TERMP_02206"/>
    </dbReference>
    <dbReference type="GeneID" id="10042521"/>
    <dbReference type="KEGG" id="tba:TERMP_02206"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2201"/>
    <dbReference type="eggNOG" id="arCOG03043">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_878843_0_0_2"/>
    <dbReference type="OMA" id="ALQECLY"/>
    <dbReference type="OrthoDB" id="70036at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="94"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="319" mass="37636" checksum="5AE4D2D3FB6D599D" modified="2011-05-03" version="1">MEEILKAIQEKDCKKVATLLYYKVDELSEEDLKEVLEKAEKLALECKDFELYKLVVYYYLEFLEIDKISEFEKLAEKEDTFEAKYHLADLYFLIGNLEKSLDLYRQLLEKETERGNKENIAKVYYNMALIHEELMEYDKALELMKKSEEILKELEREEDVLHIKIYRAYVTFEKGDIPTAKAELAKILPKVLNKPQLKAQIHLAFEEIFEEQDNYEAALQECLYAMIEAKEGEYFDIAFDALIDVIWQLMIEDEFEIIYNNIDMFTNAVPELKDFFEGIKAIALFKDGKVGREEVSEAVLKVKDRRLLDLLEFLGEAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMI8</accession>
    <name>F0LMI8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted glutamine amidotransferase class I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00991"/>
    <dbReference type="EnsemblBacteria" id="ADT83967">
        <property type="protein sequence ID" value="ADT83967"/>
        <property type="gene ID" value="TERMP_00991"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00991"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.994"/>
    <dbReference type="eggNOG" id="arCOG00088">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030756_2_0_2"/>
    <dbReference type="OMA" id="PTYHHQA"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="283" mass="31734" checksum="3DB5E35FBEA169E5" modified="2011-05-03" version="1">MKPIIGIVAQFDWETGALTINDMYVKRIKKAGGIPVAIPPLVGITDVLEAMDGLIFPEGPDIHPKYYGGELTTKIRNLDVQRDEFELTLIRAALERNLPILGIGRGAQALNVALGGTLYQDVVSEIPKAIKHDWTSGGRFLVHPSCKVHEVRIKTNSMLFEILKEKLNIEGTNEVFIGVNSFHHQAIRKLGDGIKPVAYADDGIIEGIEIPEKFAIGVQWLAEYMDEMQPLFDALVEKALEYKKGKIREEIKEEIIRQESETGKMAEEIVEEIIEELSESHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LML4</accession>
    <name>F0LML4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467291.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01017"/>
    <dbReference type="EnsemblBacteria" id="ADT83993">
        <property type="protein sequence ID" value="ADT83993"/>
        <property type="gene ID" value="TERMP_01017"/>
    </dbReference>
    <dbReference type="GeneID" id="10041334"/>
    <dbReference type="KEGG" id="tba:TERMP_01017"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1020"/>
    <dbReference type="eggNOG" id="arCOG00872">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002513_3_1_2"/>
    <dbReference type="OMA" id="HRAVGNY"/>
    <dbReference type="OrthoDB" id="3323at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12089">
        <property type="entry name" value="Hef_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041755">
        <property type="entry name" value="Hef_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="PTHR14025:SF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="341"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="770" mass="87957" checksum="551621C12C073040" modified="2011-05-03" version="1">MYLRRDLIQPRVYQEVIYAKCKDKNSLIVLPTGLGKTLIAMMIADYRLSKYGGKVLMLAPTKPLALQHRESFVRLFNLPPEKINVLTGELPPEQRAKIWERSIIITATPQTTENDLLVGRISLEDVVLLVFDEAHRAVGNYAYVYIAKEYMQQAKHPLILGLTASPGNDEEKIRQVLKNLYIEHVEVRTESSPDVRPYVQGIRFEWIKVELPGIYKEVRKLLREMLKDTLKPLAEAGLVDSYSPDIPKKDVLKAGQIINAEVAKGNYEIGKLMLHQAKAMKLHHAIELLETQGLTALRAYLKRLYEERQTKSNKELMSDPRMKKAVSLLIQARDLGLDHPKMDKLKELIKEQLEKKPNSKIIVFTNYRDTAKKIVKELVDMGIKVSRFVGQASRENDRGMSQKKQKEILDLFSQGIFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSIQRRGRTGRHKPGRVVILMAKGTRDEAYYWSSRHKEKQMIAVLKKVSEMIKKEKQASLLGFVKPKKEEEKEEITAEEEKEQRKAEVSKEEVYGKLPVRPIFVKKPKGIVIYVDSRELKSQVPKYLKELGAHIEVKTLDVGDYIVSEDVAVERKSANDFIQSIIDGRLFDQVKRLTEAYARPVIIIEGQLYGIRNVHPNAIRGALAAVTIDWGVPILFSTDAKETAQFIYLIAKREQEERKKEVAVRSEKKALTLADRQRLIVEGLPYVSATLAKRLLRHFGSVERVFTAKENELMEVEGIGEKIAREIRRVITAPYLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMP3</accession>
    <name>F0LMP3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fructose-bisphosphatase</fullName>
            <ecNumber evidence="1">3.1.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.11" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467320.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01046"/>
    <dbReference type="EnsemblBacteria" id="ADT84022">
        <property type="protein sequence ID" value="ADT84022"/>
        <property type="gene ID" value="TERMP_01046"/>
    </dbReference>
    <dbReference type="GeneID" id="26136497"/>
    <dbReference type="KEGG" id="tba:TERMP_01046"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1049"/>
    <dbReference type="eggNOG" id="arCOG01349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_5_0_2"/>
    <dbReference type="OMA" id="RWGDERY"/>
    <dbReference type="OrthoDB" id="99063at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="251" mass="27366" checksum="A7E652EC0995EECF" modified="2011-05-03" version="1">MYEWNEIALNIAKEVEKEILPFFGKPEGGKVIGVSPSGDKTKLIDKIAEDVVLNALKPLGVNIVSEEVGSIDVGSDYTVVVDPVDGSFNFIHGIPVFGFSFAVFKGNKPEYAMLYEFITKSVYEGISGEGAYLNGRPIHVRELNEKSIAISFYTRGRGVELINKVKRIRVLGAIAIELAYLAKGSLDGVLDIRDYVRPTDIAASALIAKEAGAIITDDTGKELKFELSASEKLNIIAVNDEKLLKLILESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMR1</accession>
    <name>F0LMR1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Septum site-determining MinD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NifH/BchL/ChlL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467338.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01064"/>
    <dbReference type="EnsemblBacteria" id="ADT84040">
        <property type="protein sequence ID" value="ADT84040"/>
        <property type="gene ID" value="TERMP_01064"/>
    </dbReference>
    <dbReference type="GeneID" id="10041381"/>
    <dbReference type="KEGG" id="tba:TERMP_01064"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1067"/>
    <dbReference type="eggNOG" id="arCOG00589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_3_2"/>
    <dbReference type="OMA" id="KDMAIHL"/>
    <dbReference type="OrthoDB" id="105856at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010224">
        <property type="entry name" value="MinD_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000392">
        <property type="entry name" value="NifH/frxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00142">
        <property type="entry name" value="Fer4_NifH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01969">
        <property type="entry name" value="minD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="6">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="245" mass="26323" checksum="52D41F9AAECF9931" modified="2011-05-03" version="1">MGRLISITSGKGGTGKTTTTANLAIALGKHGYKVCAIDADLTMANLSLIMGLDNVNITIHDVLAGEAKIDDAIYTTEYENVHVIPAAVDWEHVIKADPRNLPSIIKPLKSRFDFILIDCPAGLQMDAMSAMLSGEEAVIVTNPEISCITDSMKVGIVLKKAGLAILGFVLNRYGRSENDIPPEAAEEVMEIPLLAVIPEDPAIREATLEGVPVVAYKPKSEGAKAFMELAEKITRIAGYKARVMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMZ8</accession>
    <name>F0LMZ8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467425.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01151"/>
    <dbReference type="EnsemblBacteria" id="ADT84127">
        <property type="protein sequence ID" value="ADT84127"/>
        <property type="gene ID" value="TERMP_01151"/>
    </dbReference>
    <dbReference type="GeneID" id="10041468"/>
    <dbReference type="KEGG" id="tba:TERMP_01151"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1154"/>
    <dbReference type="eggNOG" id="arCOG10612">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200895_2_1_2"/>
    <dbReference type="OMA" id="FLRHIMR"/>
    <dbReference type="OrthoDB" id="131086at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019300">
        <property type="entry name" value="CooT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10133">
        <property type="entry name" value="CooT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="64" mass="7289" checksum="359C4444117AA370" modified="2011-05-03" version="1">MCQSKVIVFEDGKAEVVMTDVTLLEVKDGKIIVKNLLGKELVLEGYEIDYIDFISHKVYLRLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN04</accession>
    <name>F0LN04_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sugar fermentation stimulation protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sfsA</name>
        <name evidence="4" type="ordered locus">TERMP_01157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SfsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01157"/>
    <dbReference type="EnsemblBacteria" id="ADT84133">
        <property type="protein sequence ID" value="ADT84133"/>
        <property type="gene ID" value="TERMP_01157"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01157"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1160"/>
    <dbReference type="eggNOG" id="arCOG04115">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052299_1_0_2"/>
    <dbReference type="OMA" id="VTAHCPN"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00095">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005224">
        <property type="entry name" value="SfsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040452">
        <property type="entry name" value="SfsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041465">
        <property type="entry name" value="SfsA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30545">
        <property type="entry name" value="PTHR30545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03749">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17746">
        <property type="entry name" value="SfsA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00230">
        <property type="entry name" value="sfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SfsA_N" evidence="3">
        <location>
            <begin position="39"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="SfsA" evidence="2">
        <location>
            <begin position="108"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="256" mass="29188" checksum="3A9D3FAC60467CD1" modified="2011-05-03" version="1">MKLFAYITLRFLVTNLFNEEIQLISVILLKLPIIEGEFIKRINRFVGLVRIRGEVKKALITNTGRLEEFMIKGRKCFCIPKQGGKTDFILVAFEDKNSKGAVIDTRTQAKAFERAAELGLISWLKDCYIKKREVKVGASRLDYLLECSGEEIWVEMKSAVLREGEYAMYPDCPSLRGQKHIRELIKLREEGKRAMIVFIGALPEVRKFKPYAKGDPKIARLLKEAKAKGVEIRALSIALLPSGEVVLERDNLEVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN11</accession>
    <name>F0LN11_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="6">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiI</name>
        <name evidence="9" type="ordered locus">TERMP_01164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467438.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01164"/>
    <dbReference type="EnsemblBacteria" id="ADT84140">
        <property type="protein sequence ID" value="ADT84140"/>
        <property type="gene ID" value="TERMP_01164"/>
    </dbReference>
    <dbReference type="GeneID" id="10041481"/>
    <dbReference type="KEGG" id="tba:TERMP_01164"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1167"/>
    <dbReference type="eggNOG" id="arCOG00038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037952_4_0_2"/>
    <dbReference type="OMA" id="VIPVHIY"/>
    <dbReference type="OrthoDB" id="57901at2157"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00342">
        <property type="entry name" value="TIGR00342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="8">
        <location>
            <begin position="60"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="381" mass="43462" checksum="DAD0ECDC3CC660F7" modified="2011-05-03" version="1">MFNCVIIRYGEIGTKSKQTRRWFEQILVNNIKEALITEGVEYKSVLAKHGRIIVKTNEAKESLDVLKRVFGIVSLSPAMEVNAELEKINKTALKLFRKKKRELNLEKPKFRVTARRITKEFPLKSPEIQAKVGEYILENEEADVDLKNYDINVGIEIMEGKAYIFVDKIKAFGGLPIGTQGKVVVLLSGGIDSPVAAFLMMKRGCEVVPVHIYMGEKTLEKVRKIWNQLKKYHYGGKSDLIVIKPKERERVLRKLKELGRENYTCIFCKFMMVENADKIAREFGAKGIVMGDSLGQVASQTLENMYIVSQASDLPIYRPLIGLDKEEIVGIAKEIGTFELSTLPEDEVPFIPKHPVIRGSWEEFKKLYREIFGEEPKERGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN24</accession>
    <name>F0LN24_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467451.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01177"/>
    <dbReference type="EnsemblBacteria" id="ADT84153">
        <property type="protein sequence ID" value="ADT84153"/>
        <property type="gene ID" value="TERMP_01177"/>
    </dbReference>
    <dbReference type="GeneID" id="10041494"/>
    <dbReference type="KEGG" id="tba:TERMP_01177"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1180"/>
    <dbReference type="eggNOG" id="arCOG00624">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054505_0_0_2"/>
    <dbReference type="OMA" id="YLERDDW"/>
    <dbReference type="OrthoDB" id="45285at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="PTHR16228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="MgtE" evidence="7">
        <location>
            <begin position="55"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="MgtE" evidence="7">
        <location>
            <begin position="258"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="391" mass="43119" checksum="021D0B07DF3DD175" modified="2011-05-03" version="1">MTVFLDLKERLKEAYTATLASLVISLIIGFFGGTFLGKYFNKIRSAYPGILVILPGMMGLRGNVFGSMASRFSTMLYLGDLEPKIGEKRVLRNIVIAMMLSLIPVTILWMIGVIKGIRYHSFQILLIVISSTIFVSLLLGYFTAFVTIFSFKRGTDPDSVAAPLVASMGDLLTIPSLIAFILILEHSKTVFWTSNIGLILLLLFLVEISKVRRTELLEFKELFVIITLLALLSLISGFTLEKFSHLIQASVILGFAYPSLLSSFGNYGSVIAAKTSTKLHLGEIEKFFSVEPFLDILSLFATTPVIGSLINIFGIMLAKLILGSSVSFSLELALTYPLMALFIMFYSYTISYLLFKRDIDPDNVAIPLISNNSDIFGTIYAVLIAKLIVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN47</accession>
    <name>F0LN47_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747408.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT85186">
        <property type="protein sequence ID" value="ADT85186"/>
        <property type="gene ID" value="TERMP_02213"/>
    </dbReference>
    <dbReference type="GeneID" id="10549095"/>
    <dbReference type="KEGG" id="tba:TERMP_02213"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2207"/>
    <dbReference type="eggNOG" id="arCOG11560">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1088283_0_0_2"/>
    <dbReference type="OMA" id="KCHREYL"/>
    <dbReference type="OrthoDB" id="138336at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="255" mass="30066" checksum="1C0AC07A8B2CD6BD" modified="2011-05-03" version="1">MKFEVMEYPRTCKGCKNESFRVIKCHREYLKKLMENMRPVSLKVMKNFNRKAPDGRERDEKRMLTSILSGLIAEKLTANILNIVARCLRIDLDIQVDSENINVDTFNYEAHNDIKLTFFDKNITLEVRSSIPYALDFGRVLNEYFDILGPYLTSYKPKEYFKDYYIRVLFHYPGVKHRDIETFTDGVYNEKIQAYFVGGASREDMERLGKDISQKMKQKSAKYWGISPITRGRDAIEIISLIFDVEENEVERIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN79</accession>
    <name>F0LN79_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747440.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02245"/>
    <dbReference type="EnsemblBacteria" id="ADT85218">
        <property type="protein sequence ID" value="ADT85218"/>
        <property type="gene ID" value="TERMP_02245"/>
    </dbReference>
    <dbReference type="GeneID" id="10549069"/>
    <dbReference type="KEGG" id="tba:TERMP_02245"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2239"/>
    <dbReference type="eggNOG" id="arCOG10606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_549390_0_0_2"/>
    <dbReference type="OMA" id="PEAFFYT"/>
    <dbReference type="OrthoDB" id="20224at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="496" mass="58336" checksum="641BDCC4260F3FCA" modified="2011-05-03" version="1">MKYRDINMLNYKNLQEMEYIAALTDKVPYYDFETKRPRFIEKDKVQQLISELVKEGKFAEAKELMESSKKDYLKELEKNLTPKLLSLRISFPLWVKLYALALKHETSPSAILRRLLINAAKSLIEELNETGTITPRAYLLIKESLEGLEKLQERRTFNEDEEGRKYILIYEHEEPISVSDLKHIHYFLKRLVKAYVKRDNIPEEIVDLLFEKTVASDFETPEAFFYTYVGVFKENDEIFLRLGPEVNTLDFHYVVFEYPVRAIQEFPPEVVLKFHKKILFDAFVKCPHVIEKIKAKLERGEALTLDDYKSIFCHNFEKEIEILFREGTKPFIYPEEGQEFMHAEFLPYCFEDYPLPLFRMEFSERELKIDGIALKRKPSKNEVKENLERLRSIAKKAYYEAVGLSEEKVAEAKAKVEKGEIDEEVLEVLSVAKGVDAFLEYLLVKQEGGKDLLSAFSRSSEVFTTTFPKPLVRILELFHRKKVKEILEELILKELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN90</accession>
    <name>F0LN90_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
            <plasmid evidence="3 4">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02256"/>
    <dbReference type="EnsemblBacteria" id="ADT85229">
        <property type="protein sequence ID" value="ADT85229"/>
        <property type="gene ID" value="TERMP_02256"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02256"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2250"/>
    <dbReference type="HOGENOM" id="CLU_372861_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="139"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="745" mass="88202" checksum="118D69EC4CDB980D" modified="2011-05-03" version="1">MSRRKELLSTLSDISQILTFILTVSSIYILKIKLSRYMFNLFMYILLISILFLFCIYVIRLSMKKHKLSSYLNLMLNNLTKTQVPGILGLTVGDILKDEVFVDLPWKFLNKKEIRHDSLVLVIIDGMTMKNKSYLVLSNPGQGKSILLKKIFSKVKDQYKKNREFIPLFIEIRKISSFFEKHNNGKSFKTLLWKYLTEEEIPKFPLSYKEFENRINKGKIIFILDGLDEAPPSLLTSLNKDIEALGHCPLLISCRKNEYQLYVKNSELDQITEKIEILPMDYEKIETFVSNYIKYLYNLPEKNTMDKKINEPAGIISDFMDMLKNDKAILELAKYPLLLSMTIHLYLSEPQRLKHWNIYQLYFHYVTNIIAYETNKKQKHAKLDIDTKQKILTDLAGFLFKQNRTYFTIDELKEITNRFGVDVSLKDVKYNICNHSLIRSQGEHEYSFIHTSFQDYYTAKYIVKVLEYEKIKEGTEILKIHISSDIERFLKYMLKSLQKNAIEKVALSLKTIYNKIDLESINNNPKTKREISEIIMGKQQTAHYLAILIPYLSEDIKEDIENFLIGKLRTETNKFITRGIRVGLFRHANRKDILKEYLRLLEKDWEEREVNCGYYLMYYGDQVRSYIDLGKKDCENTVRNIIRHFLSINHKAGWPLDLITFRQCILQNEERRRLVISKGYLLEALYAIQKNLLEYMDDELTYNQLVKFINFLISLKDELEPETLSKIEDIKREIEKWRSKNGQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGV2</accession>
    <name>F0LGV2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466289.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00013"/>
    <dbReference type="EnsemblBacteria" id="ADT82991">
        <property type="protein sequence ID" value="ADT82991"/>
        <property type="gene ID" value="TERMP_00013"/>
    </dbReference>
    <dbReference type="GeneID" id="10040332"/>
    <dbReference type="KEGG" id="tba:TERMP_00013"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.12"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OMA" id="PEIVSCF"/>
    <dbReference type="OrthoDB" id="126249at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT82991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="150" mass="17250" checksum="51FD900BB887A89E" modified="2011-05-03" version="1">MPDLDEIDREILLLLKDNARMSLTDIAKKVGLSVMGVKNRIKKLEERGIIEGYSANISLSRLGYDIMAFVEISVEARVRREVAEALQKRKEVIELYEVTGTCDFMAKIVVRNMEELREFLAITLAKMEGIISTQTLLIIRNYRIKFDKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGX1</accession>
    <name>F0LGX1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467477.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01203"/>
    <dbReference type="EnsemblBacteria" id="ADT84179">
        <property type="protein sequence ID" value="ADT84179"/>
        <property type="gene ID" value="TERMP_01203"/>
    </dbReference>
    <dbReference type="GeneID" id="10041520"/>
    <dbReference type="KEGG" id="tba:TERMP_01203"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1206"/>
    <dbReference type="eggNOG" id="arCOG05058">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052780_0_0_2"/>
    <dbReference type="OMA" id="EPFRENY"/>
    <dbReference type="OrthoDB" id="43125at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="PTHR43675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="157"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="321" mass="37091" checksum="692064A9AE1B1B6E" modified="2011-05-03" version="1">MESLAKKIDKNISAMIQVAVLNILKLGMEYRIFNKLISKKHYLDILNMNSIKNKPLLKDLLDTYVEIGIVERTLNEIRMRDFSYTITFSRESISYIQPDWISVFEEMYKMITYSFISPEHPKILMDFDKDADFWDMRLSLEFNSTYRRLIASIGKLRDEMTVLDLGCGSVSPVEIGKLVGSNGKYVGVDFSPGMLSIAKSKIKELGLDWVILRELDIRTMIPRSKYDIIIMSFVLEYLPTLSLLKVIDTAMAALNEGGKLIIIEPFRENYPQIAAWEFFEKLTKEFTKFPSKSAIINSLEQTNYNFRLHEIGKSVLVVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGZ8</accession>
    <name>F0LGZ8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467504.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01230"/>
    <dbReference type="EnsemblBacteria" id="ADT84206">
        <property type="protein sequence ID" value="ADT84206"/>
        <property type="gene ID" value="TERMP_01230"/>
    </dbReference>
    <dbReference type="GeneID" id="10041547"/>
    <dbReference type="KEGG" id="tba:TERMP_01230"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1231"/>
    <dbReference type="eggNOG" id="arCOG04309">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059734_1_1_2"/>
    <dbReference type="OMA" id="EIPYQKA"/>
    <dbReference type="OrthoDB" id="71537at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="255" mass="28243" checksum="9869854E4ECEB5FE" modified="2011-05-03" version="1">MITLTTDFGTKGPYVGEMKGAILSINPKAMLIDITHSITRHSVLEGSFVMEQVVKYYPKDTVHIGVIDPGVGTERKALIIEGDQFLVVPDNGLATLPLKHINPTAAYEIDIKKMEAIIGRKISSTFHGRDVFGPAGALLDLGYEPSRLGKEISLDEIIKLDLKPKQKDGKWILKVIYIDDFGNVILNLEDYERPKYVEVEGLKIPYLDTYGQVKKGELLALPGSHDYLEIAVNQGSAAEVLGVKVGDELEVRLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH05</accession>
    <name>F0LH05_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467511.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01237"/>
    <dbReference type="EnsemblBacteria" id="ADT84213">
        <property type="protein sequence ID" value="ADT84213"/>
        <property type="gene ID" value="TERMP_01237"/>
    </dbReference>
    <dbReference type="GeneID" id="10041554"/>
    <dbReference type="KEGG" id="tba:TERMP_01237"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1239"/>
    <dbReference type="eggNOG" id="arCOG03167">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044680_0_0_2"/>
    <dbReference type="OMA" id="KIFLHNT"/>
    <dbReference type="OrthoDB" id="21850at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="49"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="435" mass="50353" checksum="B4F776093058FEA6" modified="2011-05-03" version="1">MVHPDDYITEHLLNLPTLLKPYNKPEKRELYDWLVSKINLYLKYGKADTILLLGIRGVGKTTLLAQLYFDAISKTNPNQVLYLPLDRLQAFGLSLLDVVEAYKRMIKPEKAVMLFDEAQYEESWDLKLKLLHDERKFLIVVTGSSAMRLRESPDLARRALHRELFPMTFREYYRLKTGESLPELMWKILNLEETELPPLRKEIAEYVRVGSMPLSLEMEEWEVYERLITMLDRVVYRDLREVHEFDAETLDKVFNLLYLIANPKAERFSYERLSRTLSLAKGTVIKLVNALEKAGIVQKIPIHGSLSKNIRRNPKIKFLAVPIKSALLYKAGININKEEVFASLLEDVVAFYLYLIAKAKKGRLSYEPSKGSADFVLELGSEKIVIEVGLGKEKKYQVERTMERVGAEKGIVIGKRYQIDEKVAFYPWQVFVAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH32</accession>
    <name>F0LH32_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467538.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01264"/>
    <dbReference type="EnsemblBacteria" id="ADT84240">
        <property type="protein sequence ID" value="ADT84240"/>
        <property type="gene ID" value="TERMP_01264"/>
    </dbReference>
    <dbReference type="GeneID" id="10041581"/>
    <dbReference type="KEGG" id="tba:TERMP_01264"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1267"/>
    <dbReference type="eggNOG" id="arCOG01205">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159724_1_0_2"/>
    <dbReference type="OMA" id="AGLPDYH"/>
    <dbReference type="OrthoDB" id="122104at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="118" mass="13840" checksum="FB8FA16745DE01B9" modified="2011-05-03" version="1">MANIRAWLLKKGKRRYNMIKNYEYYLPLIKKACEEVLGKCEVYVFGSVVEGKFTAGSDVDILIKVEKIPKNVKERASIIVEIEEKAGLPYDHPFELHLVDEEGFKWYVETLRVKFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH56</accession>
    <name>F0LH56_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_00040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466316.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00040"/>
    <dbReference type="EnsemblBacteria" id="ADT83018">
        <property type="protein sequence ID" value="ADT83018"/>
        <property type="gene ID" value="TERMP_00040"/>
    </dbReference>
    <dbReference type="GeneID" id="10040359"/>
    <dbReference type="KEGG" id="tba:TERMP_00040"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.39"/>
    <dbReference type="eggNOG" id="arCOG03819">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590028_0_0_2"/>
    <dbReference type="OMA" id="IHEFMTK"/>
    <dbReference type="OrthoDB" id="57041at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="438" mass="47562" checksum="D4AC71793255769A" modified="2011-05-03" version="1">MRKLTILIILLIVGYMVGIWTFLLFPQILIVGGMKALMLYIAISAVLAAVPYYSLEATKRSRYFFFEYLTKVSKTPGIGISLLMFIIIGASLILYYSSLGITSIVGKGNTLYVALAVVLSLLLSSLILFRAKEKSVVLMGWFAILFLIFTLISWYIIRNFALSVAEKAVPVQFALETLTGNIKSTHLSITFPLVIKIILLAFLGLGLGFGFYIVFGTFLPEETDSRALIGAGYVLQLLIGVLATYIVVYSLAVSFPGTAILYGHATINKATGYIVKIAAALTEIKSMQAKTVLYLLMISVYLAGMTTFIPLIETAGHIISESMQSSRNRAISVALTGVFAVSLILTSRYLRTLFLALFFSFLGIMVAVETLPLILSGNILSKRAKLYSSVVGICGLLVGISITVRTLSLGAWEKLGIVAGVVLLVPLLLNSVLLKTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH86</accession>
    <name>F0LH86_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfhydrogenase II subunit a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00070"/>
    <dbReference type="EnsemblBacteria" id="ADT83048">
        <property type="protein sequence ID" value="ADT83048"/>
        <property type="gene ID" value="TERMP_00070"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00070"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.70"/>
    <dbReference type="eggNOG" id="arCOG01549">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044556_0_0_2"/>
    <dbReference type="OMA" id="RICAICY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00508">
        <property type="entry name" value="NI_HGENASE_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="416" mass="46868" checksum="944AE4FF9E6134A7" modified="2011-05-03" version="1">MVILELGEFTRVEGNGKAEVIIENGEVKEARVKIVEGPRFFELLTLGRYYWDVPDLEARICAICYLAHSFASVLGIENAFGVKVPEEIQLLRELGLIGEILESHSLHLYLLVAPDLFGYPDAIRMASKHGEIVREGLALKAFGNYIREVIGGREIHGINVKPGGFGRYPTEDELEKIDKSCDALLRFAKRAVNIFATQEVFGAVPEYHVATDGYLYGEKLIASDGERFDYFEHIEEKSLPYSFAKQSHYKGSVFMTGALSRLMVKSDRLTPIAKELFEQHKEKLSRGYVSLNNLAQAIELVYSLERAKEIVSTLLDHGIKGENVPIEPKEGEGIGYVEAPRGVLIHHYRIDENGNITYSNIITPTALNHALMELSLYEEARKQYGTVDENFLKHKLEETVRAFDPCISCSVHFVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH97</accession>
    <name>F0LH97_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methylmalonyl-CoA decarboxylase, gamma chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00081"/>
    <dbReference type="EnsemblBacteria" id="ADT83059">
        <property type="protein sequence ID" value="ADT83059"/>
        <property type="gene ID" value="TERMP_00081"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00081"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.81"/>
    <dbReference type="eggNOG" id="arCOG05797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1954744_0_0_2"/>
    <dbReference type="OMA" id="DAWRLYG"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014497">
        <property type="entry name" value="MeMalonyl-CoA_deCOase_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005899">
        <property type="entry name" value="Na_pump_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04277">
        <property type="entry name" value="OAD_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018867">
        <property type="entry name" value="Na_decarb_PF0672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01195">
        <property type="entry name" value="oadG_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="126" mass="14431" checksum="BEF18BA77FBB89C4" modified="2011-05-03" version="1">MPAVTMQEFLEGLYITILGVTVVFTVLTILAIAMYAIGYLERRLVEKEKAKEAPVIKEEAKVEEKPKIEPKKLAVITAAILAYIAEKNAQLRPVPFKRKPSDTWRLYGLQSQMEEVEDFNYELGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHC4</accession>
    <name>F0LHC4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl6</name>
        <name evidence="5" type="ordered locus">TERMP_00108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466384.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00108"/>
    <dbReference type="EnsemblBacteria" id="ADT83086">
        <property type="protein sequence ID" value="ADT83086"/>
        <property type="gene ID" value="TERMP_00108"/>
    </dbReference>
    <dbReference type="GeneID" id="26135424"/>
    <dbReference type="KEGG" id="tba:TERMP_00108"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.109"/>
    <dbReference type="eggNOG" id="arCOG04090">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_0_0_2"/>
    <dbReference type="OMA" id="VFQDGIY"/>
    <dbReference type="OrthoDB" id="80629at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_A">
        <property type="entry name" value="Ribosomal_L6_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_L6_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019907">
        <property type="entry name" value="Ribosomal_L6P_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03653">
        <property type="entry name" value="uL6_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="4">
        <location>
            <begin position="13"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="4">
        <location>
            <begin position="97"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="184" mass="20859" checksum="A546C308906FE647" modified="2011-05-03" version="1">MPIDAWVREEVEIPEGVEVTVENNLVKVKGPKGELERELKYPGVKIFTEDGKVVIYKDFPRRKDIAIARTFKAHINNMIKGVTEGFTYKLKVVYSHFPVTVKVQGDKVIIENFLGEKAPRIAQILPGVKVKVQGQEIIVEGIDKEKVGQTAANIEQATRITKWDRRVFQDGIYIVEKAGKPIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHE2</accession>
    <name>F0LHE2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01294"/>
    <dbReference type="EnsemblBacteria" id="ADT84269">
        <property type="protein sequence ID" value="ADT84269"/>
        <property type="gene ID" value="TERMP_01294"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01294"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1296"/>
    <dbReference type="HOGENOM" id="CLU_2393058_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="101" mass="12179" checksum="A430BDA07439DB6F" modified="2011-05-03" version="1">MKIQKLQDIMDALSGWVEAAEIERNLKHAFLHDLEMFRKFLLTFLTRSTLNSINYYTLKAWESRIDALANEISRRKNPFFKLLYSRFKLSLDEFYRELGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHG0</accession>
    <name>F0LHG0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Box A-binding protein</fullName>
            <shortName evidence="6">BAP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">TATA sequence-binding protein</fullName>
            <shortName evidence="6">TBP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">TATA-box factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tbp</name>
        <name evidence="8" type="ordered locus">TERMP_01312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467585.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01312"/>
    <dbReference type="EnsemblBacteria" id="ADT84287">
        <property type="protein sequence ID" value="ADT84287"/>
        <property type="gene ID" value="TERMP_01312"/>
    </dbReference>
    <dbReference type="GeneID" id="26136793"/>
    <dbReference type="KEGG" id="tba:TERMP_01312"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1313"/>
    <dbReference type="eggNOG" id="arCOG01764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060161_4_3_2"/>
    <dbReference type="OMA" id="NCEYEPE"/>
    <dbReference type="OrthoDB" id="83880at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04518">
        <property type="entry name" value="TBP_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033711">
        <property type="entry name" value="TBP_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="PTHR10126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="1" evidence="6">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="6">
        <location>
            <begin position="102"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="190" mass="21415" checksum="5A0610555F277318" modified="2011-05-03" version="1">MVDMSKVKLRIENIVASVDLFTQLDLEKVIEICPNSKYNPEEFPGIICRFDEPKVALLVFSSGKLVVTGAKSVEDIERAVSKLVQMLSKIGTKFQRAPQIDIQNMVFSGDIGMEFNLDAVALVLPNCEYEPEQFPGVIYRVKEPRAVILLFSSGKIVCSGAKSEHDAWEAVRKLLRELEKYGLIEEEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHL7</accession>
    <name>F0LHL7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466399.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00123"/>
    <dbReference type="EnsemblBacteria" id="ADT83101">
        <property type="protein sequence ID" value="ADT83101"/>
        <property type="gene ID" value="TERMP_00123"/>
    </dbReference>
    <dbReference type="GeneID" id="10040442"/>
    <dbReference type="KEGG" id="tba:TERMP_00123"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.124"/>
    <dbReference type="eggNOG" id="arCOG03086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164851_6_2_2"/>
    <dbReference type="OMA" id="PMHRELK"/>
    <dbReference type="OrthoDB" id="129474at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="79" mass="8796" checksum="B80D72293358321E" modified="2011-05-03" version="1">MSRLPKLSGEEVIKVLVRKFGFKVSRQKGSHVVLVKYIDGRKIGTVVPLHEELKLGTLLGILKLAGVDKDEFIEVLNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHP1</accession>
    <name>F0LHP1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane-associated metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466423.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00148"/>
    <dbReference type="EnsemblBacteria" id="ADT83125">
        <property type="protein sequence ID" value="ADT83125"/>
        <property type="gene ID" value="TERMP_00148"/>
    </dbReference>
    <dbReference type="GeneID" id="10040466"/>
    <dbReference type="KEGG" id="tba:TERMP_00148"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.149"/>
    <dbReference type="eggNOG" id="arCOG05799">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335098_0_0_2"/>
    <dbReference type="OMA" id="WDEGTVM"/>
    <dbReference type="OrthoDB" id="99446at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021683">
        <property type="entry name" value="DUF3267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11667">
        <property type="entry name" value="DUF3267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="206" mass="22942" checksum="2B52B425ACE442AF" modified="2011-05-03" version="1">MDAPYSLRLNDYEGEIISLAFILFVLSGLVLSPLDFSINFASFWSVLHYLLLPLIFVVLTHEGLHALTARLFGAKVEFGISVFGKINLAPYTAVRTPLRKKKWMYIIIAPVLLSIIAYVLAFTLQSPWWGIVFVFNTSGLAGDLLILMILGKMPDDALIADEGVVMKSTHGFPGISRRVSMIIKIIALALLLYIILNFKVEVVVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHP5</accession>
    <name>F0LHP5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L15e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl15e</name>
        <name evidence="7" type="ordered locus">TERMP_00152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466427.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00152"/>
    <dbReference type="EnsemblBacteria" id="ADT83129">
        <property type="protein sequence ID" value="ADT83129"/>
        <property type="gene ID" value="TERMP_00152"/>
    </dbReference>
    <dbReference type="GeneID" id="26135479"/>
    <dbReference type="KEGG" id="tba:TERMP_00152"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.153"/>
    <dbReference type="eggNOG" id="arCOG04209">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080796_1_0_2"/>
    <dbReference type="OMA" id="KYMQELY"/>
    <dbReference type="OrthoDB" id="85023at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00256">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_L15e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020926">
        <property type="entry name" value="Ribosomal_L15e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_L15e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="PTHR11847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="194" mass="22631" checksum="DFC477EBFF021DA8" modified="2011-05-03" version="1">MGMYKYIREAWKSPKKSYVGQLLKVRMIKWRREPSVVRIERPTRLDRARSLGYQAKQGYVIVRVRVRRGGRKRPRWRGGRKPSKMGMVKYSPKKSLQWIAEEKAARKFPNLEVLNSYWVGEDGMYKWFEVIMVDPHHPVIKSDPKIAWIAMKVHKGRVFRGLTSAGKKSRGLRNKGKGAEKVRPSIRANKGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHZ2</accession>
    <name>F0LHZ2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fe-S cluster assembly SufD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467690.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01417"/>
    <dbReference type="EnsemblBacteria" id="ADT84392">
        <property type="protein sequence ID" value="ADT84392"/>
        <property type="gene ID" value="TERMP_01417"/>
    </dbReference>
    <dbReference type="GeneID" id="10041733"/>
    <dbReference type="KEGG" id="tba:TERMP_01417"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1417"/>
    <dbReference type="eggNOG" id="arCOG01715">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736928_0_0_2"/>
    <dbReference type="OMA" id="MSHHRED"/>
    <dbReference type="OrthoDB" id="104497at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="366" mass="40445" checksum="244DA731763EE130" modified="2011-05-03" version="1">MFIEREALKRLTYQKYGDSPTIKSYTKWKLFEENSPLKLPTEAKGGEVPIKGHIVLSGSDVEFSLPGGVELSEGTLGLSQPEESRILGFHFYALRKTYRLRITRDLVEPLVIVSHLSANAFISHHISIEAENVRAPIIIYDLTKEGTKSLVVELKAKNAELEVLTVGRHSSLSHYLLRASLGGGTRVKAFTVISAGEMSHHREDYSLEGAKSELILRGMPIAIGSSVDYLTNVLQYGERSKSETRVHGFSYENGWTVHRGVAKVLESARNSSSGVISQVTIMDEGSLGVSVPMLEVDTGEIESAFHSSAVRQFDEDALFYLRSRGLDSDEAMSLFVHGIGEALSSHLERLRSKARSNVRELIEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI08</accession>
    <name>F0LI08_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01433"/>
    <dbReference type="EnsemblBacteria" id="ADT84408">
        <property type="protein sequence ID" value="ADT84408"/>
        <property type="gene ID" value="TERMP_01433"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01433"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1433"/>
    <dbReference type="eggNOG" id="arCOG00021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054903_0_0_2"/>
    <dbReference type="OMA" id="EDRGPIC"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019293">
        <property type="entry name" value="ThiN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10120">
        <property type="entry name" value="ThiP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="301" mass="33967" checksum="D818E952BF12C31D" modified="2011-05-03" version="1">MGGEMKTPCVFWVEVIMPVLRAKVAQKLYEEGLTQAKIAEYLGITQAMVSKYLAGKYKKLEKDLENKLDEIAGEIANLILYGADRGEIIKFTSRKFFELFHSGFLCKYYAEYAGVEESVCREIFIATPSRSDVLERLNLALSELLQDEKFLQLIPEIRSNIAYALPEPKDFSDVAAVPGRITVVKGKAFALPPEFGVSRHTAKILLELSKVVPEIRSVINIKFNEKIEDALRKAGFKVESIEEKKRDEDKTVELIVQLFKEKGVLDAVIDKGAFGIEPCVYVFGRDPIEVVEKVKKLESHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI12</accession>
    <name>F0LI12_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="4">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dtdA</name>
        <name evidence="5" type="ordered locus">TERMP_00189</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DtdA deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466464.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00189"/>
    <dbReference type="EnsemblBacteria" id="ADT83166">
        <property type="protein sequence ID" value="ADT83166"/>
        <property type="gene ID" value="TERMP_00189"/>
    </dbReference>
    <dbReference type="GeneID" id="10040507"/>
    <dbReference type="KEGG" id="tba:TERMP_00189"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.190"/>
    <dbReference type="eggNOG" id="arCOG01616">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056464_1_0_2"/>
    <dbReference type="OMA" id="CYEATHH"/>
    <dbReference type="OrthoDB" id="84039at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00562">
        <property type="entry name" value="Deacylase_DtdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018033">
        <property type="entry name" value="Deacylase_DtdA_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007508">
        <property type="entry name" value="DtdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34667">
        <property type="entry name" value="PTHR34667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04414">
        <property type="entry name" value="tRNA_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016210">
        <property type="entry name" value="UCP016210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="272" mass="30597" checksum="04EE16B7D01FD77A" modified="2011-05-03" version="1">MKIIMTTKIDLASANIKQKLIENFGFKESDAKFDSNVVYKKGDILILTTNQEMIYYDYLDKEIERQLSIRPELIIFASRHSSKQKLPTLTTHVTGNWGKSMYGGRDNSLAIAQPTAMKLALLKMSELNDLGWMVCYEATHHGPSEVNVPSLFIEIGSSEKEWVNDRAGEILAETIMYVISNYLKKDFKVAIGIGGGHYAPKQTKVALSSELAFSHIAAKYAHPVSREMLLKSIERTAEQVEAIYVDWKGSKGETRQLARSLAEELGLEFIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI25</accession>
    <name>F0LI25_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466477.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00202"/>
    <dbReference type="EnsemblBacteria" id="ADT83179">
        <property type="protein sequence ID" value="ADT83179"/>
        <property type="gene ID" value="TERMP_00202"/>
    </dbReference>
    <dbReference type="GeneID" id="10040520"/>
    <dbReference type="KEGG" id="tba:TERMP_00202"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.202"/>
    <dbReference type="eggNOG" id="arCOG01356">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042889_0_0_2"/>
    <dbReference type="OMA" id="AHYFMPL"/>
    <dbReference type="OrthoDB" id="90547at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023980">
        <property type="entry name" value="CHP04013_B12-bd/rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04013">
        <property type="entry name" value="B12_SAM_MJ_1487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="160"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="424" mass="48699" checksum="30CD35551B33897B" modified="2011-05-03" version="1">MHEIAIRMTKRNHNAFVHLLGALESQGFDISGFLITKDFNEILKAKPKVVLYSFFTEEIWEVEKEVKILKEKFSPLLIAGGYHATAMPKHTLNVLGFDIAVIGEGEEVLYQLLTTLKRTKFKITKELLSIRGLAFYLNGEFVFTGFAKVDDFAKFPPFAESSFLIAPIEISRGCPFGCYYCQTPYIKGFKMRHRPIDQIVKYSKRMRDMRYITPNAFAYGSPGAILKLDKLEALLKALQPLRKEGRRLFYGTFPSEVRPEFVKPETLELLIKYADNRRLAIGAQSGDDVMLKAMHRLHTVRYVMEAVEYMIEYGIEPVVDFIVGLPNESEESQRKSIELMKWIMRKGGKVRAHYFMPLPGTPWARCKPSPLSEEMKKFLGRMAAKGKIEGAWGIQIQLSKKLQKLIEEFYEEPMSYVGKVNEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI31</accession>
    <name>F0LI31_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="8">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pckG</name>
        <name evidence="12" type="ordered locus">TERMP_00208</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00208"/>
    <dbReference type="EnsemblBacteria" id="ADT83185">
        <property type="protein sequence ID" value="ADT83185"/>
        <property type="gene ID" value="TERMP_00208"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00208"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.208"/>
    <dbReference type="eggNOG" id="arCOG05865">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028872_1_1_2"/>
    <dbReference type="OMA" id="GPTNNWV"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_N" evidence="11">
        <location>
            <begin position="31"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="10">
        <location>
            <begin position="247"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="223"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="387"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="274"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT83185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="628" mass="72576" checksum="F3DCADA736C7068C" modified="2011-05-03" version="1">MEITPIEYLKERLEPEQFKKIAAINNPELHEFLAKYIKLLNPSKIFVATDSKEDEEYIKKKAIEYGEEKPLATPGHTVHFDNYYDQARDKANTKILVPRGVDLGPFINTKDREEGLREIHELMKDIMVGKELFILFFVLGPKNSVFTIPAVQLTDSAYVAHSEFLLYRKGYEEFKRLGREAKFLKFVHSAGELDERKTSKNLDKRRIYIDLESETVYSVNTQYGGNTIGLKKLAFRLTIRRAVKEGWLSEHMFLMRVNGPEGRKTYFTGAFPSMCGKTSTSMIPWENIVGDDLAFIVDMKGEARGANVEAGVFGIIHGINKEDDPIIWEVLHSPNEIIFSNVLIKDGKPYWTGMGEEIPNEGENHSGKWWKGKKDAEGNEIPPSHKNARFTVRLDAFPNLDKEALDAPCGVKIGGMIYGGRDKDTWPPVREAFDWTHGVITMGAALESETTAATLGKEGVRQFNPMSILDFLSVPIGEYIQNYIRFGERLREKPKIFAVNYFLRDENGNWLNDKLDKAVWLKWMELRVHGDVDAIETPIGYIPKYEDLKRLFKQVLNKEYKREDYEKQFMIRVPELLAKIDRIEKIYREKVKDAPEVLFRVLEEERKRLLEARKKYGDYISPFQFERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI39</accession>
    <name>F0LI39_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="6">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gltX</name>
        <name evidence="10" type="ordered locus">TERMP_00216</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466491.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00216"/>
    <dbReference type="EnsemblBacteria" id="ADT83193">
        <property type="protein sequence ID" value="ADT83193"/>
        <property type="gene ID" value="TERMP_00216"/>
    </dbReference>
    <dbReference type="GeneID" id="10040534"/>
    <dbReference type="KEGG" id="tba:TERMP_00216"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.216"/>
    <dbReference type="eggNOG" id="arCOG04302">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_1_3_2"/>
    <dbReference type="OMA" id="MRFAPNP"/>
    <dbReference type="OrthoDB" id="8922at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="8">
        <location>
            <begin position="97"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="9">
        <location>
            <begin position="407"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="6">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="571" mass="66618" checksum="22ACCA2B74681397" modified="2011-05-03" version="1">MEELILKYALINAIQHNGKANPKAVIGKVLGSHPELRPKAREIVPLVNKIVEEVNKMGIKEQEAKLREIYPEFFEKKEEKHEEKKGLPPLPKAEKGKVVTRFAPNPDGAFHLGNARAAILSHEYARIYDGKFILRFDDTDPKVKRPELIFYEWIIEDLKWLGFRIDEIHYASDRLEIYYKYAEELIKMGKAYVCTCKPEEFRKLRDAGKPCPHRDEPVEIQLERWEKMLDGTYKEGEAVVRIKTDLNHPNPAVRDWPALRIIDNPDHPRTGDKYRVWPLYNFASAIDDHDLGVTHIFRGQEHAENETRQRYIYNYFGWEYPVTVHHGRLSIEGVILSKSKTRKGIQEGKYLGWDDPRLGTIRALKRRGILPEAIRELIISVGLKRSDTTISWDNLAAINRKLIDPVANRYFFVADPIPMYIKGFEEEFTAKVPLHPDHPEKGYRELKFTPEKPVYVSKDDLELLKKSEYIRLKDLFNVKLLEVSEEKIVAEFDSIEYEKAREHRWHMIHWVPEGKECEVIIPEGDELIVKKGLLEKDADVKVDDIVQFERFGFVRIDTIENGVVKAIFAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI50</accession>
    <name>F0LI50_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466502.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00227"/>
    <dbReference type="EnsemblBacteria" id="ADT83204">
        <property type="protein sequence ID" value="ADT83204"/>
        <property type="gene ID" value="TERMP_00227"/>
    </dbReference>
    <dbReference type="GeneID" id="10040545"/>
    <dbReference type="KEGG" id="tba:TERMP_00227"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.227"/>
    <dbReference type="eggNOG" id="arCOG00754">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_3_1_2"/>
    <dbReference type="OMA" id="WGVSKAN"/>
    <dbReference type="OrthoDB" id="9099at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="2">
        <location>
            <begin position="406"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="496" mass="55250" checksum="42AA19FEAF935B7C" modified="2011-05-03" version="1">MKTKVAIIGAGIVGASIARVLSKYENLEVHLIEKEADVGWGVSKANTALIHGGYDDDPDKYPMRAKLCIKGNRLWHQWVKELEIPHIWNGALIVALKDEDFDELERLLERGQRNGVPEMRIIDREELFHLEPNVNPNALGALYVPIVGQIGPIPAVIAIVENAVANGVKVHLETEVRRIKVENGEVRGVETNNGFIEADIVINAAGLYADEISKMAGIDYFEIHPRKGEYWIFDEGIPGPNHVLFPTPTPISKGVVVTTEISGHLMIGPNAQDLPKDYKEDTSTTREGLEEVWQKAQEIWPNLPPRWKVIRTFAGLRPEPTGGDFIIKAEEEVQGFINVAGIRSPGLTSAPAIGYEVRDIIERDLGIRLKEKEKWNPYRREITHFFMLQPNQINELVKKNPAYGRIVCRCNKVSEGDVLEAIDRMKFIGVKTPSVDSVKFRTKATTGTCQGSFCKVVIVNLLAKEYGIPPWKVTLKGKGSEIGIGDVKVLLRGEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI70</accession>
    <name>F0LI70_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps7</name>
        <name evidence="7" type="ordered locus">TERMP_00247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466522.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00247"/>
    <dbReference type="EnsemblBacteria" id="ADT83224">
        <property type="protein sequence ID" value="ADT83224"/>
        <property type="gene ID" value="TERMP_00247"/>
    </dbReference>
    <dbReference type="GeneID" id="26135585"/>
    <dbReference type="KEGG" id="tba:TERMP_00247"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.247"/>
    <dbReference type="eggNOG" id="arCOG04254">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063975_0_0_2"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="OrthoDB" id="80498at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_A">
        <property type="entry name" value="Ribosomal_S7_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_S5/S7_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026018">
        <property type="entry name" value="Ribosomal_S7_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="6">
        <location>
            <begin position="54"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="215" mass="24564" checksum="ABB93EEF47FABBD9" modified="2011-05-03" version="1">MAKPLQERFFIPKDLKVFGKWSTEDVVVNDPSLKPYINLEPRLLPHTHGRHAKKPFGKANVHIVERLINKVMRSGASSYKVAGHFMRREHRSLMSKKMKAYEVVKEAFEIIEKRTKQNPIQVLIRAIENAAPREDTTTVMFGGIRYHVAVDISPLRRLDVALRNIALGASAKCYRNKMSYAEALAEEIIAAANKDTKSYAYSKKEEIERIAQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI84</accession>
    <name>F0LI84_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467712.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01439"/>
    <dbReference type="EnsemblBacteria" id="ADT84414">
        <property type="protein sequence ID" value="ADT84414"/>
        <property type="gene ID" value="TERMP_01439"/>
    </dbReference>
    <dbReference type="GeneID" id="10041755"/>
    <dbReference type="KEGG" id="tba:TERMP_01439"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1439"/>
    <dbReference type="eggNOG" id="arCOG00065">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_2"/>
    <dbReference type="OMA" id="HKLCGPT"/>
    <dbReference type="OrthoDB" id="24071at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="18"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="396" mass="44068" checksum="E7B09DA7A94BF760" modified="2011-05-03" version="1">MRIPEDVRKDIPLTQEVIYFDNTATSLTPIPVVKAMDEYYLKYRANVHRGVHKLSQMATHKYEESRKIVADFIGAKFEEIVFTKNTSESLNLVALGLEWKKGDRIVTTPYEHHSDLLPWQRVARKYGAKLEIIEGDDEGNLDLSDAEKKIKGAKLVAVQHVSNALGVIHEVEEIGKMAKEEGAIFVVDAAQSVGHMEVDVRKIHADFLAFSGHKGPLGPTGIGVLYINEEMFDIFDPPLVGGGTIEDVDLCCYKLTAPPERYEAGTPNIGGAIGLAAGIKYIEKIGLDKIEKQEHKLVKRTTEGLTELEIPWYGPRNLKKHAGVVSFNVPPLHPHDVAAILDEHNIMVRSGHHCALPVMKRLGINGTVRASFHVYNSIEEVETFLGVMEELVKSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI90</accession>
    <name>F0LI90_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable phosphoglucosamine mutase</fullName>
            <ecNumber evidence="5">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glmM</name>
        <name evidence="11" type="ordered locus">TERMP_01445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467718.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01445"/>
    <dbReference type="EnsemblBacteria" id="ADT84420">
        <property type="protein sequence ID" value="ADT84420"/>
        <property type="gene ID" value="TERMP_01445"/>
    </dbReference>
    <dbReference type="GeneID" id="10041761"/>
    <dbReference type="KEGG" id="tba:TERMP_01445"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1445"/>
    <dbReference type="eggNOG" id="arCOG00767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_2"/>
    <dbReference type="OMA" id="KCSQVMY"/>
    <dbReference type="OrthoDB" id="58941at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03087">
        <property type="entry name" value="PGM_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_A">
        <property type="entry name" value="GlmM_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023666">
        <property type="entry name" value="GlmM_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="151"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="255"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="366"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT84420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="449" mass="49357" checksum="09845B04070BFD12" modified="2011-05-03" version="1">MGKYFGTSGIREIVNERLTPELALKVGKALGTYLGGGKVIVGIDTRTSGEMLKNALISGLLSTGVDVIDIGISPTPLTGFAIKLYEADAGVTITASHNPPEYNGIKVWQPNGMAYTSEMENELEKILESESFRKVAWNEIGKLSHADPKGEYIKKILDIIELETSYTVVLDSGNGAGSLVSPYLQRELGNRVISLNAHPSGYFVRELEPNAKSLEWLAKTVKVMKADVGIAHDGDADRIGVVDDQGNFVEYEVTLSLISGYMLRKFGKGRIITTVDAGFALDDYIMPLGGEVVRVKVGDVAVAEGIVKENAVFGGEPSGTWIIPQWNLTPDGIFAGALVLEMIDKLGPLSELAKEVPRYVTMRAKIPCPNEKKKKAMEIIEREALKSFEYEKLIDIDGIRIENSDWWILFRPSGTEPIMRITLEAHTKEKAEELMRKAKEVVERAIREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIA9</accession>
    <name>F0LIA9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467737.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01464"/>
    <dbReference type="EnsemblBacteria" id="ADT84439">
        <property type="protein sequence ID" value="ADT84439"/>
        <property type="gene ID" value="TERMP_01464"/>
    </dbReference>
    <dbReference type="GeneID" id="10041780"/>
    <dbReference type="KEGG" id="tba:TERMP_01464"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1464"/>
    <dbReference type="eggNOG" id="arCOG05882">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1485956_0_0_2"/>
    <dbReference type="OMA" id="TRMFVGH"/>
    <dbReference type="OrthoDB" id="103539at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="181" mass="21044" checksum="22594D012DBADF99" modified="2011-05-03" version="1">MGLFSSLIQRKFKNIAGRRYERILKEYKEFLLTEEEMRLPEIKSILMPLDRFIGEIPPEIYETLSAYNDVRVILVYIIDAHVFHVIEQTLGKDISEEFRRKEENDGKLLLEKIAKNFEDLGISPQVRLFFGDKGEDVIKLAEKHDMLVLSKAYGSEITKTHPLSPVVLKIVQHVDIPVIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIC7</accession>
    <name>F0LIC7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane bound hydrogenase MbhC-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467755.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01482"/>
    <dbReference type="EnsemblBacteria" id="ADT84457">
        <property type="protein sequence ID" value="ADT84457"/>
        <property type="gene ID" value="TERMP_01482"/>
    </dbReference>
    <dbReference type="GeneID" id="26136970"/>
    <dbReference type="KEGG" id="tba:TERMP_01482"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1482"/>
    <dbReference type="eggNOG" id="arCOG03082">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121334_0_6_2"/>
    <dbReference type="OMA" id="HMLAKAA"/>
    <dbReference type="OrthoDB" id="105926at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="116" mass="12787" checksum="49C22D111526D86F" modified="2011-05-03" version="1">MIEYVITVFLAIGVIFNFLASIGILRFPDVYTRIHAATKCTTFGTIFIVLATVVYSLYNWLPTHDPRWVTIGIHSALVVIFLVLTNPVGAHAIGRAARKSGIRPYGAVIDELEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIF1</accession>
    <name>F0LIF1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01506</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467779.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01506"/>
    <dbReference type="EnsemblBacteria" id="ADT84481">
        <property type="protein sequence ID" value="ADT84481"/>
        <property type="gene ID" value="TERMP_01506"/>
    </dbReference>
    <dbReference type="GeneID" id="10041822"/>
    <dbReference type="KEGG" id="tba:TERMP_01506"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1506"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="IMCAFLV"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="242" mass="26569" checksum="352072C9111FE8D2" modified="2011-05-03" version="1">MTAVKVENLEKDYGKVKALKGISFEVKEGEIFGLIGPNGAGKSTTLKILATLLVPTGGKAEVFGYDVVSKADEVRKLISYLPEEAGAYKNLTGYEYLEFMAKLYAKTGKSIEEMLKLGVKIAGLGERIHDKVATYSKGMTRKLLLARALMVMPKLAILDEPASGLDIINAYAIRQTIKRFAEEGVTFLISSHNMLEVEFLCDKVALINKGVIVEIGTPKELKEKYNAENLEEVFMKAVGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIH0</accession>
    <name>F0LIH0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00267"/>
    <dbReference type="EnsemblBacteria" id="ADT83244">
        <property type="protein sequence ID" value="ADT83244"/>
        <property type="gene ID" value="TERMP_00267"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00267"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.267"/>
    <dbReference type="eggNOG" id="arCOG05806">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_707168_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="336" mass="37725" checksum="935CA9C1D7590F63" modified="2011-05-03" version="1">MNIHLAILSVLRAVQLTFRNFIYGIHRGEIYAYIMLLGFIPFVASFYSNDPYLPYIALLFTISSFAFIYLFKKGLLGKPRKDEFHILLRYSSFAFLGTLSGVFLVQGPYFLSEKLGNALIAGKVSASLSAAFLLTYLPQVLQSAIMPLYSYKYGKEELNYVKLLAERTTELLSTFTAFVVFALLLVGREVISFLFGFNLGNEFYIALLAVEIYIAYNPSIVALNSTRYVKEGSFIATVGALVALITWIPLIRMLNEYGAVMGLLLGYLTILCGTAYLSHKKLKISPKSYKPLLFAIPLQLLVFTSKIVLFTGILLYMLTIKDKIKEGIKAFHGRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIH8</accession>
    <name>F0LIH8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Maltose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466550.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00275"/>
    <dbReference type="EnsemblBacteria" id="ADT83252">
        <property type="protein sequence ID" value="ADT83252"/>
        <property type="gene ID" value="TERMP_00275"/>
    </dbReference>
    <dbReference type="GeneID" id="10040593"/>
    <dbReference type="KEGG" id="tba:TERMP_00275"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.275"/>
    <dbReference type="eggNOG" id="arCOG07158">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006285_2_1_2"/>
    <dbReference type="OMA" id="EAYCIPF"/>
    <dbReference type="OrthoDB" id="29128at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="2">
        <location>
            <begin position="297"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="3">
        <location>
            <begin position="688"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="748" mass="86829" checksum="2C2A37DB5836D98D" modified="2011-05-03" version="1">MKFHFSFKEYDPKAEAVYGTILTLGNGYIGIRGEIELEPTIYGTTIAGVYDYAPYFYREIVNAPRVIGLQIFFNGEPISLSTQKILKYERELNIEDATLKTLIAIETQSRTRIEYESIRIVHGKIKNLILLKFKIKANEDGMLTIISPIKTNVVNPSYRNEIMVKHLNVMQMEDRENEIYAEVETLDGRYRIGIASSLISGTKAKRAVIKSADGIAEILTLSVKKNKTYEFIKYITILSSKTPTPNLREAVLQKLQIAKNSCFSRLYEEHKDYWKEIWKRAKIEIEGDKNAENGLNFSIFHLIQSMPIDSRISLTARGIHGFGYRGHIFWDTEIYALPFFMAVFPEKAREMLMYRYNNLNAARENAKMNGYSGAQFPWESADDGYEATPSVIPLDMMGKKVVKIYTGEEEHHITADIAYAVELYYKFTGDEEFMFRYGLEIILETARFWASRVEYDEKKGYVIKKVIGPDEYHEHVDNSFFTNLMARYNLLLAVKYFKIARRSGGEWSKTLKRINITEKEVQRWLEIAEKIYIPRQKNGVFEEFEGYFDLSDYTLDPYGLGEKRLPEEIRRNLRKTKIIKQADVIAAQYLLKDQFDLETIRKNFDYYIIRTTHASSLSMPPYAIVASWLDYEDLAYDYFMKCAFIDLHNLYGNTQDGFHLATAGGVWQIIFRGLCGIDINNEGVEINPKLPKKWKAVRLRFFFKKALLSLEVRKDSVRVKLLKGEEVKIRAFGRNAVVKRGKETILHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LII0</accession>
    <name>F0LII0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00277"/>
    <dbReference type="EnsemblBacteria" id="ADT83254">
        <property type="protein sequence ID" value="ADT83254"/>
        <property type="gene ID" value="TERMP_00277"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00277"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.277"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062979_1_0_2"/>
    <dbReference type="OMA" id="KRYVYSV"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="3">
        <location>
            <begin position="114"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="354" mass="40551" checksum="1CD3F9349FD02D59" modified="2011-05-03" version="1">MTMSTATLIEKLQELGLTKREAEVYLTIWTKNGATVKELLDSLDVHQPQLYNIIQSLIRKGFVKASAGRPRIYTATDIVSLIDVYKMKLDLLKETLKEELMKIRSRTEEEGPYISVVRSLEGVMSSVIETINSAEIEIRAEVPYNVFKEIKPYLLSALQRGVNLYLLVYPGKESFEEFQRFKNQVKIRTSELGNFLLVISDLSVAVYSKRRFFSPNKLPLSNSEIYGYEIQEKDLLLRLLNIHNNLWRKAKEIISWDYEPEAYPKTFLEFSIVLDEIEALFKLGYIPIVTVEGRNVKEGSPVKIVGRARSVNRSGIISNFVLETNDGEVTVGGFDAEVEDIEAQRVIIERIEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIK1</accession>
    <name>F0LIK1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyS</name>
        <name evidence="10" type="ordered locus">TERMP_00298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466573.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00298"/>
    <dbReference type="EnsemblBacteria" id="ADT83275">
        <property type="protein sequence ID" value="ADT83275"/>
        <property type="gene ID" value="TERMP_00298"/>
    </dbReference>
    <dbReference type="GeneID" id="10040616"/>
    <dbReference type="KEGG" id="tba:TERMP_00298"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.298"/>
    <dbReference type="eggNOG" id="arCOG00405">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_2_1_2"/>
    <dbReference type="OMA" id="EPSYGID"/>
    <dbReference type="OrthoDB" id="32623at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_A">
        <property type="entry name" value="Gly_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022960">
        <property type="entry name" value="Gly_tRNA_ligase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="4"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="210"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="437"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="370"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="195"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="205"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="322"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="441"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="570" mass="66494" checksum="AC700BAD5D50262C" modified="2011-05-03" version="1">MKIDKYEILSDLMRRRGFAWGSFEIYGGARGFYDYGPLGATIKRKIERKIREAFQREGFFELETPDITPEEVFIASGHVEKFVDPLVECTQCHTRYRADHLIEESLDIDVEGLSAEELTKIIKENGIKCPQCGGELGDVWYFNLMFETYIGPYKDKKGYLRPETAQGIFVNFKRLNAFARNKLPFGVFQIGKAYRNEISPRQGMIRLREFTQAEVEIFFNPKETEHPHFDEVKDEVVRLYPIEHQLKNLGMIEVTLEEAVKKGYVMNTFFAYYMAMVKRILLDIGIPEKAIRFRQQLPEERAHYSKDTWDVEIYSERFGWIECVGIAYRGDYDLSRHMKMSGADLTVMIHYDEPKTVKRLKVSLNMKRVGPKLKKDAKRINEKLKEMSEEELRKLVEELEEEGKVSIEGYELEKEDFIIKEVEEKITGEKIVPHVLEPSFGIDRPFYLLLENSLTIDEDGRIYLKIKKDMAPIEVAVLPLVAKEPLTTIAYNVFRTLQKAGFIAVYDEKDTIGRRYARYDEIGTPYCVTIDNQTPEDNTVTIRDRDTREQIRVKIDELPEKLKELIFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIM1</accession>
    <name>F0LIM1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466593.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00318"/>
    <dbReference type="EnsemblBacteria" id="ADT83295">
        <property type="protein sequence ID" value="ADT83295"/>
        <property type="gene ID" value="TERMP_00318"/>
    </dbReference>
    <dbReference type="GeneID" id="10040636"/>
    <dbReference type="KEGG" id="tba:TERMP_00318"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.318"/>
    <dbReference type="eggNOG" id="arCOG00666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_2_2"/>
    <dbReference type="OMA" id="PFLTHQL"/>
    <dbReference type="OrthoDB" id="61185at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="413" mass="46977" checksum="9B10D3AF8EF2E810" modified="2011-05-03" version="1">MKAVILAGGFGTRLRPISSTRPKPMVPVLGKPNLQYLLENLEKIKEIDEIILSVHYMRGEIREFIEEKMSDYPKDIRFVNDPMPLETGGALKNVEEYVSDEFLVIYGDVFTNFNFAELIESHKKNDGLITVALTKVYDPEKYGVVITDEEGKVVEFEEKPKRPKTNLVDAGIYVVDKEILKEIPRGKEVYFEREILPKFVSQGLVYGHKMPKENYWVDLGSPEDLFYAHQIALDEIAREDGYFTIKEDAEVPEDVEIQGPVYIDSGAKVGHGVKIKAYTYIGPNTIIEDKAYLKRSILIGSDIIKEKSEIKDSILGEGVVIGKNVILKEGAVVGDYAKVYDNLVIYGAKILPWKKVEEYEAYIRIKLDPTKVRPELTPDRCPLGLPECIYKKFRAIAGEKPPCDECIENQWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIM5</accession>
    <name>F0LIM5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466597.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00322"/>
    <dbReference type="EnsemblBacteria" id="ADT83299">
        <property type="protein sequence ID" value="ADT83299"/>
        <property type="gene ID" value="TERMP_00322"/>
    </dbReference>
    <dbReference type="GeneID" id="10040640"/>
    <dbReference type="KEGG" id="tba:TERMP_00322"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.322"/>
    <dbReference type="eggNOG" id="arCOG01723">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105244_2_0_2"/>
    <dbReference type="OMA" id="VKFRVNF"/>
    <dbReference type="OrthoDB" id="89705at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="PTHR21028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00318">
        <property type="entry name" value="cyaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="173" mass="20807" checksum="37BC2985A0CBCC60" modified="2011-05-03" version="1">MEIEVKFRVNFENIRRKIEDLGAKFVGEEIQEDLYFALPSKQLLRIRKIVNLDEVILGYKQIKDERNEEFDEIEVKVGDFEKMRVILKRLGFTEDVWVRKHRFVYKLGDITFELNKVEGLGDFLDIEVIAEDVQEAKRRIWEVAHMLGLREEDVEPRLYQEMLKEPLKHVRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIS9</accession>
    <name>F0LIS9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate:ferredoxin oxidoreductase delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotetramer of one alpha, one beta, one delta and one gamma chain.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467829.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01556"/>
    <dbReference type="EnsemblBacteria" id="ADT84531">
        <property type="protein sequence ID" value="ADT84531"/>
        <property type="gene ID" value="TERMP_01556"/>
    </dbReference>
    <dbReference type="GeneID" id="26137246"/>
    <dbReference type="KEGG" id="tba:TERMP_01556"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1556"/>
    <dbReference type="eggNOG" id="arCOG01605">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_1_1_2"/>
    <dbReference type="OMA" id="GSWRTFK"/>
    <dbReference type="OrthoDB" id="125632at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011898">
        <property type="entry name" value="PorD_KorD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43724">
        <property type="entry name" value="PTHR43724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02179">
        <property type="entry name" value="PorD_KorD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="105" mass="12014" checksum="A5FFF1A6895F0697" modified="2011-05-03" version="1">MAESPFKADIERVEKELTEKMTPGAIAYIPGSSVINKTGSWRVFKPEFNKDKCIRCFLCYTYCPEPAIYLDEENYPVFDYDYCKGCGICANECPTKAITMVREVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ02</accession>
    <name>F0LJ02_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466646.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00371"/>
    <dbReference type="EnsemblBacteria" id="ADT83348">
        <property type="protein sequence ID" value="ADT83348"/>
        <property type="gene ID" value="TERMP_00371"/>
    </dbReference>
    <dbReference type="GeneID" id="10040689"/>
    <dbReference type="KEGG" id="tba:TERMP_00371"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.371"/>
    <dbReference type="eggNOG" id="arCOG01105">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1399800_0_0_2"/>
    <dbReference type="OMA" id="PEHKRIM"/>
    <dbReference type="OrthoDB" id="98249at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="32"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="118"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="194" mass="23448" checksum="D2C5F6E05A6E75F2" modified="2011-05-03" version="1">MESPLEVYMKKAEIEEKVKEVLREVSKMPLKDILSYIIKGEKDATDLYTFLYENVPSRYLKEKFRQFMEVEISHDKKVTEIFNTLYPNEEPSDVPFESWTNVFKDREFKIKTLRDYLDILEVAMKSERLAEEVYLYVSKHIPNPEYKGLFIELAKDEHDHYEFLKQEYETYEKAKAEQDFQELIKELMKDKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ10</accession>
    <name>F0LJ10_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA helicase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466654.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00379"/>
    <dbReference type="EnsemblBacteria" id="ADT83356">
        <property type="protein sequence ID" value="ADT83356"/>
        <property type="gene ID" value="TERMP_00379"/>
    </dbReference>
    <dbReference type="GeneID" id="10040697"/>
    <dbReference type="KEGG" id="tba:TERMP_00379"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.379"/>
    <dbReference type="eggNOG" id="arCOG04881">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060249_0_0_2"/>
    <dbReference type="OMA" id="HAFTPWT"/>
    <dbReference type="OrthoDB" id="29545at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005287">
        <property type="entry name" value="CHP00375"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00375">
        <property type="entry name" value="TIGR00375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="421" mass="47972" checksum="D7F2ED81B0C57261" modified="2011-05-03" version="1">MHVDADLHIHSRYSKAVSKLMVFPVLAEYAKLKGLNVVGTGDILNHRWEEELLKHAEKVDEGTYEIKGVRFLLTAEVEDSRRVHHVLIFPSIDAVREMRECLRKHSKDIDSEGRPHLNLRGAEIADLANEFDVLIGPAHAFTPWTALYKEYDSLKECYENAEVHFLELGLSADSQMADMIKAHHRLTYLSNSDAHSPQPHRLGREFNRFEVKDATFEEIRKAILKRGGRKIILNAGLDPRLGKYHLTACSKCYAKYKLEDAKRLNWKCERCGGAIKKGVRDRILELADTRGRPKDRPPYLHLAPLAEIISMVTGKGIETKSVKAVWERLLREFGSEIKVLVDVPIESIAQLIGEDIAKAIWAFRNEKLIIIPGGGGKYGEIKLPDEIKRAKIQDLNSIEIKQEEVYYKPKQASILSFLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ72</accession>
    <name>F0LJ72_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine_BP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467892.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01619"/>
    <dbReference type="EnsemblBacteria" id="ADT84594">
        <property type="protein sequence ID" value="ADT84594"/>
        <property type="gene ID" value="TERMP_01619"/>
    </dbReference>
    <dbReference type="GeneID" id="26137183"/>
    <dbReference type="KEGG" id="tba:TERMP_01619"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1619"/>
    <dbReference type="eggNOG" id="arCOG04373">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137479_3_1_2"/>
    <dbReference type="OMA" id="AYGTNIE"/>
    <dbReference type="OrthoDB" id="126214at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00106">
        <property type="entry name" value="TIGR00106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="100" mass="11312" checksum="4AF64307E3050E83" modified="2011-05-03" version="1">MVIIEFVIVPLGELSLSKYVAEVIKLLEKKGVKYQLTPMGTIIEVPTVSEGLKVIEEAHELMFKLGAKRVSTTIRIDDRRDKKVKMEDKVESVLEKAREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJA4</accession>
    <name>F0LJA4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen synthase/ADP-glucose transglucosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467924.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01651"/>
    <dbReference type="EnsemblBacteria" id="ADT84626">
        <property type="protein sequence ID" value="ADT84626"/>
        <property type="gene ID" value="TERMP_01651"/>
    </dbReference>
    <dbReference type="GeneID" id="10041967"/>
    <dbReference type="KEGG" id="tba:TERMP_01651"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1650"/>
    <dbReference type="eggNOG" id="arCOG01420">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_3_2"/>
    <dbReference type="OMA" id="MPSRWEP"/>
    <dbReference type="OrthoDB" id="83551at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="4">
        <location>
            <begin position="2"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="253"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="456" mass="51632" checksum="FF94C621AA11D54D" modified="2011-05-03" version="1">MKILMLGFEYLPVKVGGLAEAITSIAETLAELGNEVLVFTPSHGFKEGKEYTSFKVDVSGHVWDVKVYERKQNGVRVFSISDPLLDNPDVYGPGWEGMLSKAVHFGKASVGLLNRIIENEGKPEVIHAHDWHTVFAAGLLKKYFQIHLVATIHRLNKSKVPAYYFHMANLGELAPYPDIDPEHTLCYIADLITTVSKSYLREEWAFFGMFEGKVTHVFNGIACDFWNEEFLENKDLPREERRKKILESLGLSDGIAFMFIGRFDKAQKGVDTLLRAIEILAEGYPQEFSKMRFIIIGKGDPELESWAHAMESRYPSNVKVITKMLKREFTRELYGSVDFVVVPSYFEPFGLVQMEAMCLGAIPIGSAVGGIKDTIVSLDEDEKNATGLLVPPRDAFALAHAMLKMAKLREENPELLKKMRVNGKRRAKEVFTWENACKRYLRAYKSDIDKAVSFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJC2</accession>
    <name>F0LJC2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467942.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01669"/>
    <dbReference type="EnsemblBacteria" id="ADT84644">
        <property type="protein sequence ID" value="ADT84644"/>
        <property type="gene ID" value="TERMP_01669"/>
    </dbReference>
    <dbReference type="GeneID" id="10041985"/>
    <dbReference type="KEGG" id="tba:TERMP_01669"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1668"/>
    <dbReference type="eggNOG" id="arCOG04020">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_712938_0_0_2"/>
    <dbReference type="OMA" id="SYLCLEC"/>
    <dbReference type="OrthoDB" id="56882at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="401" mass="44964" checksum="C134F36016C1CDA9" modified="2011-05-03" version="1">MVKSRVYVVVLILASLMMLGAAYIIGSEKYSNIEDAQKGDIVVFTGICVYSKGDFSVLTDGLETITIYKGLIEGKIYTIQGKVVNKKRKSVYPLRVTNGSTEELHLSYLSGVYWDDHSCYILTPQKVKLDRCLNVQKGAEIQAKGVIYGGTFYIISFEVGNFLKEPQDSFPYRVVGVVLDNRTPTIIWNGKEKIKVYLPYRFSLKLGDKVEILGIVRLYSTLTLYVNSIDDVKITGKAERKPIGEEEIGDIAHGSCQVTKAGKGLSLNCTDLKLYAYSARTGDIVEFEALRRERSLVCLNCSVKLPREKLGNSICTPEHEGVIKIEGRISWIRIYKNGFGLANITNDKCWILLKLRKSLNLELKENQTITAFGIYTTYRGKPALEVHSRDDVCLENSCLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJD1</accession>
    <name>F0LJD1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466695.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00420"/>
    <dbReference type="EnsemblBacteria" id="ADT83397">
        <property type="protein sequence ID" value="ADT83397"/>
        <property type="gene ID" value="TERMP_00420"/>
    </dbReference>
    <dbReference type="GeneID" id="10040738"/>
    <dbReference type="KEGG" id="tba:TERMP_00420"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.420"/>
    <dbReference type="eggNOG" id="arCOG01049">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062599_1_1_2"/>
    <dbReference type="OMA" id="FRGIPTM"/>
    <dbReference type="OrthoDB" id="64048at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="261" mass="29166" checksum="C2C37C9A93339060" modified="2011-05-03" version="1">MFKFSKEYKAKTVVKVDGVKFGEGFTIIAGPCSVETEEQIMKTAEFLSGLGVKVLRGGTFKPRTSPYSFQGHGEKALRWLKKAGEEFGLVTVSEVMDTGKVELVSKYVDILQIGTRNAQNFDLLKEVGKRDKPVILKRGFANTIQEWLYSAEYILAEGNENVILCERGIRTFETSTRFTLDISAVPVVKELSHLPIIVDPSHAAGKRSLVKPLSRAALAVGADGIMVEVHPKPEKAMSDSKQQLNFEEFKELLEDLRKWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJD8</accession>
    <name>F0LJD8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chorismate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466702.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00427"/>
    <dbReference type="EnsemblBacteria" id="ADT83404">
        <property type="protein sequence ID" value="ADT83404"/>
        <property type="gene ID" value="TERMP_00427"/>
    </dbReference>
    <dbReference type="GeneID" id="10040745"/>
    <dbReference type="KEGG" id="tba:TERMP_00427"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.427"/>
    <dbReference type="eggNOG" id="arCOG02098">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131518_3_0_2"/>
    <dbReference type="OMA" id="IRDEKRE"/>
    <dbReference type="OrthoDB" id="130328at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010958">
        <property type="entry name" value="Chorismate_mutase_highGC-bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01808">
        <property type="entry name" value="CM_M_hiGC-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="76" mass="9301" checksum="FD4665BC98677727" modified="2011-05-03" version="1">MERLNELRKKIDEIDKQIIELLEERVRIAKEIGEIKRELNLPIRDEKREEEVLRRAGKFKEVFEKIVEVCRDVQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJE1</accession>
    <name>F0LJE1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoserine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00430"/>
    <dbReference type="EnsemblBacteria" id="ADT83407">
        <property type="protein sequence ID" value="ADT83407"/>
        <property type="gene ID" value="TERMP_00430"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00430"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.430"/>
    <dbReference type="eggNOG" id="arCOG01158">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036368_4_5_2"/>
    <dbReference type="OMA" id="LTDFEFW"/>
    <dbReference type="OrthoDB" id="105892at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="196" mass="22199" checksum="9EC92E888A42EFC5" modified="2011-05-03" version="1">MEKIAFIDVEGTLTDFEFWNEIANYVENGDEIRALLHLGLTGKINWLQGFLMRIDLIRGLEISTVKKVSEKFKLKNRTIKTISYLKQDGFKIILISGMFKEVIGKELSKSKADIISNNLIVKNGIVVGANLNFIDKGSVVKRYRRQNVFVLAVGDGANDLPMFRWADIKICVGGNPVLRREADFCINDFTEIINVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJH5</accession>
    <name>F0LJH5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00464"/>
    <dbReference type="EnsemblBacteria" id="ADT83441">
        <property type="protein sequence ID" value="ADT83441"/>
        <property type="gene ID" value="TERMP_00464"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00464"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.464"/>
    <dbReference type="HOGENOM" id="CLU_3039243_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="54" mass="6669" checksum="5A005937882E6410" modified="2011-05-03" version="1">MDETPGELIKQLKRELALMKERYEKALKDQEILLRELERLREENEKLRKERSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJK1</accession>
    <name>F0LJK1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="11">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">thrS</name>
        <name evidence="13" type="ordered locus">TERMP_00490</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="11"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466765.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00490"/>
    <dbReference type="EnsemblBacteria" id="ADT83467">
        <property type="protein sequence ID" value="ADT83467"/>
        <property type="gene ID" value="TERMP_00490"/>
    </dbReference>
    <dbReference type="GeneID" id="10040808"/>
    <dbReference type="KEGG" id="tba:TERMP_00490"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.490"/>
    <dbReference type="eggNOG" id="arCOG00401">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029833_0_0_2"/>
    <dbReference type="OMA" id="DAHIFML"/>
    <dbReference type="OrthoDB" id="11656at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015011">
        <property type="entry name" value="Threonyl-tRNA_syn_edit_dom_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08915">
        <property type="entry name" value="tRNA-Thr_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="12">
        <location>
            <begin position="209"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT83467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="625" mass="73094" checksum="EB7E3C202B6BA17D" modified="2011-05-03" version="1">MRMLLIHSDYLEYEVKDKALKKPEEISEEQKKGRLDEVLAVFVSVEKVDEQNPEEVVEKAVAEIKDVASQVKAQNIFVYPFAHLSSELASPDAALKILKAVEEKLKEEGFNVKRAPFGYYKAFKLSCKGHPLAELSRTIVPGEVKKEEEVPEALKKEEELVSYWYILTPEGELVEVDKFDFTGHENLRKFANYEISKSRIAEKEPPHVKIMLEQELVDYEPGSDPGNLRYYPKGRLIKSLLEQYVTEKVIEYGAMEVETPIMYDFEHPALEKYLNRFPARQYIVKSGDKKYFLRFAACFGQFLIKKDATISYKHLPLRMYELTRYSFRREKRGELSGLRRLRAFTMPDMHTVAKDLKQAMEEFKKQYKLSMEVLKGVGLTPDDYEVAIRFTEDFWNENKDFVVELVKIIGKPVLIEMWKQRFFYFILKFEFNFVDNLDKAAALSTVQIDVENAERFGITYYDEDGKEKHPLILHCSPSGAIERVMYAILEKQAKLRNQGKKPMYPLWLSPIQVRVIPVNEDYLDYALYIAGKLEGARIRVDVDDTSDRLTKKIRKAEKEWIPYIIVVGENEKRQGIITVRKREDGKQYEMQLEDLIKEIKQRTEGFPYKPRPLPLLLSQRPKFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJL7</accession>
    <name>F0LJL7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467957.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01684"/>
    <dbReference type="EnsemblBacteria" id="ADT84659">
        <property type="protein sequence ID" value="ADT84659"/>
        <property type="gene ID" value="TERMP_01684"/>
    </dbReference>
    <dbReference type="GeneID" id="26137117"/>
    <dbReference type="KEGG" id="tba:TERMP_01684"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1683"/>
    <dbReference type="eggNOG" id="arCOG00181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="YEPAHPY"/>
    <dbReference type="OrthoDB" id="43111at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="319" mass="35715" checksum="870E7F33B4BE2325" modified="2011-05-03" version="1">MAKTVLEVKDLKMYYFTSRGVVKAVDNVSFELKKGEVLGLAGESGCGKSSLGFTLMGMPTPPGKIVGGSVKIDGREIVGLPEDVLRREIRWQKISMIFQGAMNALNPVYTIGYQMIEPLIYHKGMEKEEALDRAMKYLELVGLSPEIVYRYPHELSGGMKQRVVIATALILEPEVVIADEPTTALDVVVQAQIINLMKKLKKELGLSMIFITHDLSILAEISDRVAIMYAGKIIEIGDSQKIYYEPAHPYTQKLLAAIPRLHEDVDKLEFIPGQPPNLIKPPSGCRFHPRCPYAMQVCKEQEPELKEIDKDHYAACWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJM7</accession>
    <name>F0LJM7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">V-type ATP synthase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">V-ATPase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpD</name>
        <name evidence="8" type="ordered locus">TERMP_01694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467967.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01694"/>
    <dbReference type="EnsemblBacteria" id="ADT84669">
        <property type="protein sequence ID" value="ADT84669"/>
        <property type="gene ID" value="TERMP_01694"/>
    </dbReference>
    <dbReference type="GeneID" id="10042010"/>
    <dbReference type="KEGG" id="tba:TERMP_01694"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1693"/>
    <dbReference type="eggNOG" id="arCOG04101">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069688_2_1_2"/>
    <dbReference type="OMA" id="SKNIMGV"/>
    <dbReference type="OrthoDB" id="93236at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="215" mass="25170" checksum="0654348D3D297EB7" modified="2011-05-03" version="1">MPEMLKVKPTRMELLKLKRRIKLAEKGHKLLKEKQDALIMEFFTIYDEALNLRRELNQKIGEAFETLRLAEIDVGVLRLKEIALGVKPNKEVEIRKRNIMGVSVPLIEAESFKRKPDERGYTFVASSPRVDLAAEKFEEVLELAIRLAEVEETLKRLAKEIEKTKRRVNALEYIIIPRMQATVKFISQHLDEMERENFFRLKRVKAILEARAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJP4</accession>
    <name>F0LJP4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467984.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01711"/>
    <dbReference type="EnsemblBacteria" id="ADT84686">
        <property type="protein sequence ID" value="ADT84686"/>
        <property type="gene ID" value="TERMP_01711"/>
    </dbReference>
    <dbReference type="GeneID" id="10042027"/>
    <dbReference type="KEGG" id="tba:TERMP_01711"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1710"/>
    <dbReference type="eggNOG" id="arCOG02579">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126379_0_0_2"/>
    <dbReference type="OMA" id="ICRIYPF"/>
    <dbReference type="OrthoDB" id="85209at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="169" mass="19925" checksum="D87FD50498AB0CB2" modified="2011-05-03" version="1">MRFKPKPLKSDVKFKCKFCVDCCRGRFIYLTLYDIKRIAEHGHDPQDFVLFTAENGKIRFVLAYREWDLGCVFHDPETGKCRIHDYNPLVCRIYPFMVSHRPLGVEREEPFEYKGKKLWLYYDESCPGIGEGKEIITREEIAELGLNFKEEFDKTDLDGLSKILDEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJQ3</accession>
    <name>F0LJQ3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467993.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01720"/>
    <dbReference type="EnsemblBacteria" id="ADT84695">
        <property type="protein sequence ID" value="ADT84695"/>
        <property type="gene ID" value="TERMP_01720"/>
    </dbReference>
    <dbReference type="GeneID" id="10042036"/>
    <dbReference type="KEGG" id="tba:TERMP_01720"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1719"/>
    <dbReference type="HOGENOM" id="CLU_2327384_0_0_2"/>
    <dbReference type="OMA" id="LGIEFYY"/>
    <dbReference type="OrthoDB" id="131255at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="98" mass="11113" checksum="13F11C496B3CC10F" modified="2011-05-03" version="1">MNTRTLAPLYIFIGLMGITATLLYPGFYPPNPINPIFFSAFLIFGLHLYGVKKAVIYGMFLLLLLLSLGIEFYYLLNAQLKNATLFLITPYLWVSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJQ5</accession>
    <name>F0LJQ5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467995.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01722"/>
    <dbReference type="EnsemblBacteria" id="ADT84697">
        <property type="protein sequence ID" value="ADT84697"/>
        <property type="gene ID" value="TERMP_01722"/>
    </dbReference>
    <dbReference type="GeneID" id="10042038"/>
    <dbReference type="KEGG" id="tba:TERMP_01722"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1721"/>
    <dbReference type="eggNOG" id="arCOG01997">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079909_1_0_2"/>
    <dbReference type="OMA" id="IRMIFPQ"/>
    <dbReference type="OrthoDB" id="99403at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="203" mass="21674" checksum="DD46AA8A1EBD1612" modified="2011-05-03" version="1">MIGEILSASLLMLIMIDPSDKILLVSLLREDFHIEDIKQLIIRANLIGFILLIIFAVAGKIILQDIFHIDLNALKIAGGFVLFKIGLEALEGGGMVTLKKEKNILALAAVPVATPLIAGPAAITTAITLTAEYGIKVSASAILIAILLTALLMFVTLYMIENISKTTLGVFIRIIGLFTMAIGAQMMVEGVGGIFLRLLESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJW4</accession>
    <name>F0LJW4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00524"/>
    <dbReference type="EnsemblBacteria" id="ADT83501">
        <property type="protein sequence ID" value="ADT83501"/>
        <property type="gene ID" value="TERMP_00524"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00524"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.524"/>
    <dbReference type="eggNOG" id="arCOG00980">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073526_1_0_2"/>
    <dbReference type="OMA" id="IREFHRH"/>
    <dbReference type="OrthoDB" id="116879at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="301" mass="33829" checksum="9CC528C82194D276" modified="2011-05-03" version="1">MLMKVGRGDVVRLHYIGKVKETGEIFDTTYEEVAKEAGIYSEKGIYGPVPIAIGAGHVLKGLDEQLEGLEVGKKYTIEVPPEKAFGRRDPKLIKTFTLGQFRRQGIMPFPGLEVEIETESGKKLKGRVLSVSSGRVRVDFNHPLAGKTIIYEVEIVEKIEDPIEKVKALIELRLPMVDLSKVKIEVGEKDVKIDFSDVEIDKNTLILGEIILESDLKFIGYEQVEFKPTIDDLLKPPEVKVEEEIEKEVKEQKSGEEATEESKEEAEKKTEGVKESAEKTEEEKTAEVKEEKEEAKEEAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK08</accession>
    <name>F0LK08_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466843.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00568"/>
    <dbReference type="EnsemblBacteria" id="ADT83545">
        <property type="protein sequence ID" value="ADT83545"/>
        <property type="gene ID" value="TERMP_00568"/>
    </dbReference>
    <dbReference type="GeneID" id="10040886"/>
    <dbReference type="KEGG" id="tba:TERMP_00568"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.569"/>
    <dbReference type="eggNOG" id="arCOG00929">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047631_1_1_2"/>
    <dbReference type="OMA" id="RIHFRQA"/>
    <dbReference type="OrthoDB" id="80668at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="190" mass="20861" checksum="0114E7829FEDF172" modified="2011-05-03" version="1">MSRANVNFKKIAEVQRKLSKRIVEKPLDISRIKTIGAVDVSYKKGKAKAAFVLCSFPSCEILKAKVIETNVDFPYIPTFFFLRETRPVLLAIRGETFDVLLVEGHGKAHPRGYGLASHIGLLLKKPTIGIAKKPLRGYPEGSLVKVGKAYVSVGNLIDLNSAAKIVEMVNENGYPKPLKIADKLSKGAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK60</accession>
    <name>F0LK60_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468068.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01797"/>
    <dbReference type="EnsemblBacteria" id="ADT84772">
        <property type="protein sequence ID" value="ADT84772"/>
        <property type="gene ID" value="TERMP_01797"/>
    </dbReference>
    <dbReference type="GeneID" id="10042113"/>
    <dbReference type="KEGG" id="tba:TERMP_01797"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1796"/>
    <dbReference type="eggNOG" id="arCOG10032">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_827992_0_0_2"/>
    <dbReference type="OMA" id="YVQFNAT"/>
    <dbReference type="OrthoDB" id="59258at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027552">
        <property type="entry name" value="CGP_CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04288">
        <property type="entry name" value="CGP_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="368" mass="42528" checksum="9139FE8DBEAB99FE" modified="2011-05-03" version="1">MSERLKAGAILLIFFFSLGLINQAVAYPPQQIFDIQIFMTITESGTASVKMTAKLIDPYLLSYLNNLQKNDPQKAQKEFHDMVFSLIFLNLQEFIQSQTNKTVIITPQTGFIELHPNWTTTLNFKIYNYLILKNGTLKSAVYGPMRFIFKNKVLSYHWKKLTIIFPKNAYIINLAPVPKEMTENVAVWENGDYLPIIVLTFNETVFQKERAKKTKIIPFKEFLDNSTKVINLRYDPFAGTVTFNGSIIGMKPEQYHIAKLIDEFNMSMDLIKFDIKSTENGVTFSGEAKPMLQYKETLTKKVWNITIRLPFRFDKVNIKAPKDQSVQMIYEKTDNTIVNMVFEEKKICGPGVIVGLALFPLLLRKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK82</accession>
    <name>F0LK82_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TrkA-like system potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a potassium transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468090.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01819"/>
    <dbReference type="EnsemblBacteria" id="ADT84794">
        <property type="protein sequence ID" value="ADT84794"/>
        <property type="gene ID" value="TERMP_01819"/>
    </dbReference>
    <dbReference type="GeneID" id="10042135"/>
    <dbReference type="KEGG" id="tba:TERMP_01819"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1818"/>
    <dbReference type="eggNOG" id="arCOG01959">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_0_0_2"/>
    <dbReference type="OMA" id="IACQVAY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="4">
        <location>
            <begin position="189"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="388" mass="42703" checksum="E406BC682773AC28" modified="2011-05-03" version="1">MKVIVVGAGRTGFLIAKWLSMKHEVTVVDRNPRILDEISYALDVFTIPGDATLPETLKRAEVENADYVIATTDNDQTNIIVCSLSKTLGSPFTIARVKRIEYLKVWGHGRRTLGVDLMVCAAPLVAEGIVRVMEYPQLVFFRKLYGDIYVGMSSSHIKTPWSFKIDDKNIIIATKNMIERSFKKSKTKKVLILGAGETGRIVAKMLSAKGKEVKLVEDDFKKANEIADELDGVTVIAGNPFSDFLWSEENLSEADIAVVAFDQDYKCFFASALAKEKGIDRVFSMVHRSSHIPLFEKIGAISFSPELETAGKITAAVRGKAVLGVVTRPEFQVYALSGEFLEGTPLENLSGIPGPLFRDGRLVLPTPKMKIRKGDIVTVITEGGGMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKA0</accession>
    <name>F0LKA0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00581"/>
    <dbReference type="EnsemblBacteria" id="ADT83558">
        <property type="protein sequence ID" value="ADT83558"/>
        <property type="gene ID" value="TERMP_00581"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00581"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.582"/>
    <dbReference type="eggNOG" id="arCOG02620">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_800819_0_0_2"/>
    <dbReference type="OMA" id="GRIRFYQ"/>
    <dbReference type="OrthoDB" id="54794at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="353" mass="41417" checksum="2C129AC114709CE2" modified="2011-05-03" version="1">MRYAEVKEMYDDPFHLDESSAIQYLRNIFEFHFQNTPYWHAVEKKRGIDLDSIFEGSLEETVEKIFNSGLSIESDELRENWLGFLPRNYKGKLRFYQSSGTTGPRSFCHWDHEYVDLLVFYLRRALDEVYHLDETYNDSHQLRALLHGPYGWYQEEMSELVWSYGGILYFVATETEGLKKILEKEGIQAAMKYLAPLVRYTQRVLERDEINLIRTAVQLLDIFKPFGENLETIMLSGTSTTPEVIKHYQDYFENSVFIPLYGYFAFGDAIGVHRGKNIQYYPNYPFTVILPLVPENGRYRIAKYWERGLTGIIIARPEILIVKIEDELITRVPPIKPFEWDGFANPSREGVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKA5</accession>
    <name>F0LKA5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466861.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83563">
        <property type="protein sequence ID" value="ADT83563"/>
        <property type="gene ID" value="TERMP_00586"/>
    </dbReference>
    <dbReference type="GeneID" id="10040904"/>
    <dbReference type="KEGG" id="tba:TERMP_00586"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.587"/>
    <dbReference type="eggNOG" id="arCOG07080">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1582981_0_0_2"/>
    <dbReference type="OMA" id="FGKFIYI"/>
    <dbReference type="OrthoDB" id="97252at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="174" mass="20452" checksum="5541FC8ABDACA27D" modified="2011-05-03" version="1">MLFGKLISPRYHLRIWKLKFEKEKIKEGLRLRSIKFIEFHDNSYDAELKVDSLLASAVNEKYVYLMKFDDGNLLVISKKPLTKEGILKQDAYLVRDEATLKKLILSQSSKKAQILMEFQPFIVWFPIAVILVYLSKRISTLEFLLAFGGYFVIKKLLRILEYYILGVLQRIGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKE6</accession>
    <name>F0LKE6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466902.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00627"/>
    <dbReference type="EnsemblBacteria" id="ADT83604">
        <property type="protein sequence ID" value="ADT83604"/>
        <property type="gene ID" value="TERMP_00627"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="83" mass="9536" checksum="73BAE5782837D7A6" modified="2011-05-03" version="1">MGEELILAYGLGIPKTYRAIFKELGKAGIIDKNLQTVLESLVFYRNAIAHEYYDIDGEEIFEVINSLDAVRRFVKRVKEILQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKE7</accession>
    <name>F0LKE7_THEBM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
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            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="ADT83605">
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="50" mass="5928" checksum="15E02A7EBD4EF531" modified="2011-05-03" version="1">MFDIERIGKIISDIERFLSDLDSMEIKNVDDLRDRKTFYASSMLIFVILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKJ0</accession>
    <name>F0LKJ0_THEBM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="GeneID" id="10042165"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1665586_0_0_2"/>
    <dbReference type="OMA" id="LRYWASK"/>
    <dbReference type="OrthoDB" id="75696at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="145" mass="17453" checksum="F0934FB672D7EF47" modified="2011-05-03" version="1">MTKYLIKLKYIRPMKLLFEKEQKMAEFIPFLPIEGENKYVKGKIEGKARVFLPEFLDFARKLGFNIKGKVLEGENDENYLRLFVYAMVSQFVKSETERREIERTVMELPILALRYWASTFRNAYWEGGRKRVRRISKCFRVIYCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKK6</accession>
    <name>F0LKK6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">TERMP_01865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84840">
        <property type="protein sequence ID" value="ADT84840"/>
        <property type="gene ID" value="TERMP_01865"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01865"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1864"/>
    <dbReference type="HOGENOM" id="CLU_2550453_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="82" mass="9388" checksum="F2B1A419B92CB666" modified="2011-05-03" version="1">MGKIREHGTVKNLLDISKPTLIGNEVRKFSESELHEIISKALSSKGALFELNFTLTVEKHPKEGLILRHYIFVPLSRELEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKK9</accession>
    <name>F0LKK9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468139.1">
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01868"/>
    <dbReference type="EnsemblBacteria" id="ADT84843">
        <property type="protein sequence ID" value="ADT84843"/>
        <property type="gene ID" value="TERMP_01868"/>
    </dbReference>
    <dbReference type="GeneID" id="10042184"/>
    <dbReference type="KEGG" id="tba:TERMP_01868"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1867"/>
    <dbReference type="eggNOG" id="arCOG00369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1136106_0_0_2"/>
    <dbReference type="OMA" id="NQIERDY"/>
    <dbReference type="OrthoDB" id="78723at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="255" mass="30013" checksum="4AEEA27BD1683309" modified="2011-05-03" version="1">MHEFDKSIFKFLMSSGGTIASNLKPYLSLALEIYGVFEIISKFIQWRREVERKRRLRKSLASTFQKKLDKAKRDLEQLADDIAYAFGALFMYSTAIPPFEPKEKAQRIVNQIERDYKEMTKSMYELMKLVRRHRNMIIDALDLDETQILLLDGLATAFKNETPDIESLTDYLPLIVEEIQKSKKERQIFSQELGKQLGKFNSTYGLVTINHALGINRQYKQCFKKAARHGIREFLRRFNECRTRPKQKHLPPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKP2</accession>
    <name>F0LKP2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T2SSF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468172.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01901"/>
    <dbReference type="EnsemblBacteria" id="ADT84876">
        <property type="protein sequence ID" value="ADT84876"/>
        <property type="gene ID" value="TERMP_01901"/>
    </dbReference>
    <dbReference type="GeneID" id="10042217"/>
    <dbReference type="KEGG" id="tba:TERMP_01901"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1900"/>
    <dbReference type="eggNOG" id="arCOG01811">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077875_0_0_2"/>
    <dbReference type="OMA" id="NRMIITC"/>
    <dbReference type="OrthoDB" id="59695at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="102"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="302" mass="32987" checksum="717945195FE6E310" modified="2011-05-03" version="1">MVRVQITPYLVKITEKVIPKKLLKKYDLLLYSAGIAFRASEYLLMSFLISIIIGTVLSMLNSIYGVVAFIVTLISTIWVYPYWRIVKRIEDMEQMLPDAFFYLASSLRAGISFSEALEELTTAKFGALTEEFRKTVAEIKKGRPTVEALKAFALRNKKSPVIYRSMMIIIEALERGAPMADVLVSVGNDVREILRIKKERKASTGMQTMFFIIASGFVGPLILGVVSQVIAGLSGVGGSVILPISSIKNILLIFVALQAIISGIGIGVIREGKFLGGLKYSAVLAVVGVIVFNLAGSINLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKR7</accession>
    <name>F0LKR7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466944.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00669"/>
    <dbReference type="EnsemblBacteria" id="ADT83646">
        <property type="protein sequence ID" value="ADT83646"/>
        <property type="gene ID" value="TERMP_00669"/>
    </dbReference>
    <dbReference type="GeneID" id="10040987"/>
    <dbReference type="KEGG" id="tba:TERMP_00669"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.671"/>
    <dbReference type="eggNOG" id="arCOG05015">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061951_0_0_2"/>
    <dbReference type="OMA" id="RREKVPW"/>
    <dbReference type="OrthoDB" id="86760at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009452">
        <property type="term" value="P:7-methylguanosine RNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="376" mass="44496" checksum="9822BD37E186CBD9" modified="2011-05-03" version="1">MEEYIELAVEMIKKGFDERKIKARLPRENADEIIEIARARIRAKDKFSRRDLWMDLEGLRYATHEAVAEYRAKRVKPESIADVSCGIGIQLIFFAKYAEEAYAIDIDERKLFYAMKNAEKYGVKEKIKFIHGDSLSEEVIKQVNADVIFSDPARPPEMPERRLEDLLPSPLEIYEAYKHKTDAFIFDLPPQIRREKVPWKGEFEYIDLYGQLNRLTFYFEPLAKAERSAVLLPKGVRLESNPDLENIIEWSEPKEYLYEIPQSIDYADLINELFHTVKGKLYMLLREKRRVLATSDDEIKSEYFKRAYVITGIVKFHPLRINEFLRREGFGRATLRISIPDSEYWRFRRKVENNLKGERRAYIFQYKDKAIIAEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKS4</accession>
    <name>F0LKS4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466951.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00676"/>
    <dbReference type="EnsemblBacteria" id="ADT83653">
        <property type="protein sequence ID" value="ADT83653"/>
        <property type="gene ID" value="TERMP_00676"/>
    </dbReference>
    <dbReference type="GeneID" id="10040994"/>
    <dbReference type="KEGG" id="tba:TERMP_00676"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.677"/>
    <dbReference type="eggNOG" id="arCOG00555">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000809_3_2_2"/>
    <dbReference type="OMA" id="CIQSPKC"/>
    <dbReference type="OrthoDB" id="796at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="55"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="265"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="892" mass="104598" checksum="689B54836B0E5668" modified="2011-05-03" version="1">MIKELFSNLESEIVSVREFPPKEGIYGEFAFKNPEINQLVENLGFRLYKHQVEALKKLYSGRNIVVTTPTASGKSEIFRLAIFDNYLSNPQHTYLLIYPTRALINNQYEKFSLENFHFFQITKKMVNAKILTGDVEWNERRIILREKPRVIFTTPDMLHYNILRNLKDYEWLLKNLRYLVVDELHVYRGVFGTNAAYVFRRLLKALKRLGAKPQIITLSATLRNPKEFAEDFFGLEFEAVTGATNPFPKRYLILFEPRRLNEMQLLRAVVEKLAEKGVKTLVFFDSRKGTEKLMRFLLSSPAVYKTSTYKGTLPKNIRWEIERDFKEGRLLVLLTTNALELGIDIGDLDAVINYGIPPDGLFSLIQRFGRAGRLKKREAINGIVLRKNGLDYYYKEHLDELVERLEKGIIEYMPVNLKNRLVVKKHLHYLLTELKVLDWDELNDFEKAVAEELIKEKKAKLYENPLTGKKELRILRPAFSYSSIRTASDESYFLVLDEPWIRYKLLEKESLSDLLRFINWLKLKGYLIEEVDNPEYYRSLLPGMAYFSRGELYMAKDKLKIGKFHFIFAKQLNRFWEVETFASKREEVEILEIYKKKQFKDAEIYIGRLKVKHRYWGFAVKGKDTHLYLQELIKLREEGILKGEIYAPLVGGFEFTELSDEEWEILDWEKFAKVEFDEPLEREFETDGIWLVFPDKIREIAREEFHKFFRIALEKDQGDLAFSIYERLDRRKLFPELLGATTYYIRKTIGDVLEKAKSKDDELALAIKKMIDSKDGIGNGLHAIEHNMIKIAPIFTYVDSRELGGYSYESFPNPPHIGKPIVFIYDGNEGGFGLAEILYENAEKLMEKSFEHLKSCKCIDGCPLCVYSPKCGTFNEFLDKWQAMKIWEGVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKW3</accession>
    <name>F0LKW3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA m(1)G methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00715"/>
    <dbReference type="EnsemblBacteria" id="ADT83692">
        <property type="protein sequence ID" value="ADT83692"/>
        <property type="gene ID" value="TERMP_00715"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00715"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.717"/>
    <dbReference type="eggNOG" id="arCOG00967">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061952_0_0_2"/>
    <dbReference type="OMA" id="LNIRWED"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="RNA_MeTrfase_TK0422/Sfm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016742">
        <property type="entry name" value="tRNA_m1G_mtfrase_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="RNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018978">
        <property type="entry name" value="tRNA_m1G_mtfrase_arc_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="4">
        <location>
            <begin position="103"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="387" mass="44645" checksum="496D7A9668282F75" modified="2011-05-03" version="1">MRENLKNSLTMLKPMPMKKLSEIFAELLREKGINKIGMLSKRYRKSRNKLQDIALDVLEGKGAIVEVDEPTAIAWDLSGRRTGEAKYAYAPSCIAKKFKVVISPGDLRARLPNDCPYFIIDLMHWEKHTEKEKNKVALQAAQSYGVLRDYLWSELLALTWINEEFKEKAHFPLDRVTAYEGPTAEFLKEKGIDEVVLLDPRAEEVLSEEDFSVGAFIIGGIVDTGGTKKGTTAKIGEALESEGIKVRRRKIVLRGDIIGVPDRINHILKILLEMLVEGKSMEEAILTVQSPLHARWRLRKELPKHKRRYLIDGRKYLVVEKELFDEYSRWLNIRWEDFVQVLRELNFVALERKRIHHLNKIAVARIINGKLYRVILLKRAALLCYNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKY6</accession>
    <name>F0LKY6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="ADT84893">
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        <property type="gene ID" value="TERMP_01918"/>
    </dbReference>
    <dbReference type="GeneID" id="10042234"/>
    <dbReference type="KEGG" id="tba:TERMP_01918"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1917"/>
    <dbReference type="eggNOG" id="arCOG04219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027052_1_0_2"/>
    <dbReference type="OMA" id="IDPGTTT"/>
    <dbReference type="OrthoDB" id="9617at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007408">
        <property type="entry name" value="DUF460"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40707">
        <property type="entry name" value="PTHR40707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04312">
        <property type="entry name" value="DUF460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="417"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="661" mass="76056" checksum="0DFA137E9AD32BC7" modified="2011-05-03" version="1">MPILILGVDIISENPKRFAVVSWFNGRLEKKGEFTFYRLVRFIRAKRPDIIAMDNIHELGDELKKFLRALPQGTKLVQVTGRPGEQRSLWSLARENGIRVGDKFDPYEEAKVCALLASKGVGYEVLAFEDEVIIKVSRGRSQGKGGWSQDRYRRRVHNLIQNKVREIEEALRKADIPFDLEVEEKDYGLARGEFKVYASREELAGLIKPMHGGDVEIKINPVERKSLEFVPLKSEKAIQVRKSVIVGLDPGITVGIAALDLDGNIVAVYSERNMAVSDIVRFISDIGHPIILATDVNPAPGLVEKIARSFKAILYVPRESLRVEEKNELLRSLGISVDDDHQRDALAAAYKAYLRLKPKLEHVDAKLRELGLMKKSNEIKALVIQGYNLGEAIMKVKLRERPKEEIKALPEEESVDVTPYIEKIKELERTIEMLERENQELRAIIEEQKKKIEKLEDKLAYYDEEVRAKVIKSREIEIRDKRIAYLEKELREAKAIIEKLSRDLVLAKRMHLLELKGSAVPLKVLENLTWKEIERLERSAQIKKDDIIYVVNPSGAGKSIAEHLVEKGIRALISAKTLPDNVYGVLRENKVPVFYEDEIEVKRVDEFAIVDREELERAIEQKLAQWEEEDREKEIQEFLKLVEEYRIERIKELKRKAEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL00</accession>
    <name>F0LL00_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468203.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01932"/>
    <dbReference type="EnsemblBacteria" id="ADT84907">
        <property type="protein sequence ID" value="ADT84907"/>
        <property type="gene ID" value="TERMP_01932"/>
    </dbReference>
    <dbReference type="GeneID" id="10042248"/>
    <dbReference type="KEGG" id="tba:TERMP_01932"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1931"/>
    <dbReference type="eggNOG" id="arCOG01403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_4_2"/>
    <dbReference type="OMA" id="TVIYEAM"/>
    <dbReference type="OrthoDB" id="66448at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="92"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="206"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="403" mass="45746" checksum="DD3A4C0CA2EE54FA" modified="2011-05-03" version="1">MRIIFLASNFPDPVNKTWAPWNKSAVDSVLEFAEPIVIAPRPFAPPFSKFSKIPKYNRHFGYPVHYPRFLYLLPKSLFYCLTGESYRCFVGRYILKGVEQGNIQKPDVIHALHPYLDGYGSVPIAKKLKVPLVVTVHSPNNLKVCSKKVLSALEHADKIVAVAKFIVKKLEDIGISGEKIEYISLGVNTEEFKPLSEKDSQIVVSKYKIDPTDRVILYVGRLTKNKNIKTLLLAIWEVFRTSPKLRANTKIVIVGDGPERDSLQKLVKELGLSKNVIFTGLVSHDSRELRELYGIADIFVLPSFSEGKPVALYEAMSSGCAIIASNVGGIPEQVFDNINGFLIHPNDVNGLARKLIYLLENEKDLERMKRESRKLIFELGYTWEEYEKRIRQVYEYILNSQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL05</accession>
    <name>F0LL05_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalt-zinc-cadmium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468208.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01937"/>
    <dbReference type="EnsemblBacteria" id="ADT84912">
        <property type="protein sequence ID" value="ADT84912"/>
        <property type="gene ID" value="TERMP_01937"/>
    </dbReference>
    <dbReference type="GeneID" id="10042253"/>
    <dbReference type="KEGG" id="tba:TERMP_01937"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1936"/>
    <dbReference type="eggNOG" id="arCOG01474">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_3_2"/>
    <dbReference type="OMA" id="IEMHLIV"/>
    <dbReference type="OrthoDB" id="110591at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="208"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="286" mass="31765" checksum="D10101617C7CAD74" modified="2011-05-03" version="1">MREVYKPIWFSIIGNVLLALLKIAVGFMYSSLALISDGVHSLSDVVTSIIGFIGIRISSKPPDRSHPFGHSRFEPLFAFFMGLALLLVAYEIARDSIGRVLEGTSIEVNSIMLGVAVFSIIFKEGMTQYTLWVGKKLNNQILIADAYHHRSDVLSTIAVLIGLLAEKFGFRYGDSLAGLIVAIFIAKVALEIVMRNVNYLTGTSPPFEICERIKKIALSVDNVVGVHDLRAHYVGPKLHVELHIEVPPNLTLKEAHDVSEEVKRRIEELEEVEMAFVHVDIKGVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL28</accession>
    <name>F0LL28_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468231.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01961"/>
    <dbReference type="EnsemblBacteria" id="ADT84935">
        <property type="protein sequence ID" value="ADT84935"/>
        <property type="gene ID" value="TERMP_01961"/>
    </dbReference>
    <dbReference type="GeneID" id="10042276"/>
    <dbReference type="KEGG" id="tba:TERMP_01961"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1959"/>
    <dbReference type="eggNOG" id="arCOG02009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018751_2_0_2"/>
    <dbReference type="OMA" id="YTHRHYG"/>
    <dbReference type="OrthoDB" id="12448at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="156"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="530" mass="56948" checksum="F7F88F5FC3D4406E" modified="2011-05-03" version="1">MADFGVLSLLPPLVAIILAIWTKRVILALFAGVWIGGVMVSGWNPITGTTQTLDWIVGNAIDDWNAKILLFDFLIGAGVGLIYKSGGAMAIARALTRTVKTSRAASLMGWLLGVLVFFDDYTNTIIVGNTMRPITDRTRVSREMLAYIDDSTAAPVAGLALVSTWIGYEVGLIGDSFKDLGVSLGPYAAWLSSVPYRFYSIFAIILVFLVAYTHRHYGAMLHAEYRARTTGKVIRDGAKPLMTTEIDLGMPKEGGNVHTFIWPILTLVFVTLYGMWITGGGSETYASDGLMGVLSNSDPALALLWGSFAMVVVAFFLVLGFKIMTIEEAETAIVQGMKQMIIANTILLLAWSIKSATDAVGTADYVVSIASGVLSPGIVPLVIFLIAMFISFTTGTSWGTFSIMMPIAIPLAYHLSGQAGPVLFASIGAVFAGGIFGDHCSPISDTTIMSSMFSGSDHIDHVTTQIPYAVTAASVGIVLYLLFAIGVRTWAVLLPIGLILLVAAHWLLSEWYGKKYGIPHGKVPIYVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL31</accession>
    <name>F0LL31_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468234.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01964"/>
    <dbReference type="EnsemblBacteria" id="ADT84938">
        <property type="protein sequence ID" value="ADT84938"/>
        <property type="gene ID" value="TERMP_01964"/>
    </dbReference>
    <dbReference type="GeneID" id="10042279"/>
    <dbReference type="KEGG" id="tba:TERMP_01964"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1962"/>
    <dbReference type="eggNOG" id="arCOG00933">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023791_0_0_2"/>
    <dbReference type="OMA" id="RCDIHYA"/>
    <dbReference type="OrthoDB" id="13164at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034471">
        <property type="entry name" value="7_8-dihydro-6-hydroxymethylpte"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034474">
        <property type="entry name" value="Methyltransferase_Class_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43306">
        <property type="entry name" value="PTHR43306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00385">
        <property type="entry name" value="7_8-dihydro-6-hydroxymethylpte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01100">
        <property type="entry name" value="methyltransferase_(Class_D)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="133"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="583" mass="68055" checksum="CC6065E4AFC4F890" modified="2011-05-03" version="1">MSETVGEIPSGEKEFDELTKKVRDIIEYPELSEEEFQKLLKKASKGYGGSLPHKTYSLCPETRKVVPAVVWEKNGIVWITKKCPEGLITDAYYEDVEMYYKFREWKFDEKKLMSFNVENSGVNCPFDCGLCPRHRSHTNLLNIVLTNRCNLSCWYCFFYAKEGQPIYEPTLEQIRMMLRNAKRENPIGATAVQFTGGEPTLREDLIEIIRIAKEEGYDHIQLNTDGIRLAFEPELVKKIREAGVNTLYLSYDGMTPQTNWKNHWEIPLIFENVRKAGGPGIVLVPTTIRNVNDHELGAIINFGLNHLDIVRGVNFQPISLVGRVPKKERQRFRITIPGAIKKIEEQTNGAIAKEDWYPIPIAGHIAKFFESFAGSKYYMTSHFGCGAATYVFLDDDKVIPISRFLDVEGFVEFLEEKAEELSKWKKLGRLEKLKVGAEIFLKFKSFYDEKYAPKSFDVLDIIKNAFAHGTYDALGQFHYKTLFLGMMHFMDEYNYDVERVERCVIHYAMPDGRIVPFCTFNVIPELYRDKVQAQFSYSWEEWKAMHPDWEYKKDKYVRTREFVEKMKNSEIYRKTYIDIKQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL41</accession>
    <name>F0LL41_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01974"/>
    <dbReference type="EnsemblBacteria" id="ADT84948">
        <property type="protein sequence ID" value="ADT84948"/>
        <property type="gene ID" value="TERMP_01974"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01974"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1972"/>
    <dbReference type="HOGENOM" id="CLU_3228011_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="43" mass="4846" checksum="27A260B8163C8F27" modified="2011-05-03" version="1">MPTTLPGIGRFKTLTTISPRKRKPKIIANPLYMVHQDKLRGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL42</accession>
    <name>F0LL42_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Antiholin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01975"/>
    <dbReference type="EnsemblBacteria" id="ADT84949">
        <property type="protein sequence ID" value="ADT84949"/>
        <property type="gene ID" value="TERMP_01975"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01975"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1973"/>
    <dbReference type="eggNOG" id="arCOG03636">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113736_2_2_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005538">
        <property type="entry name" value="LrgA/CidA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33931">
        <property type="entry name" value="PTHR33931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03788">
        <property type="entry name" value="LrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="81" mass="8974" checksum="F423EEE7F52D0318" modified="2011-05-03" version="1">MILLTLALIFNVVKIEDVEKEAELFVKNMSIMFIPPGVGIVLYWGLIKSQAVPIFVALIVSFFVTIILTAKFVEFLGGKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL64</accession>
    <name>F0LL64_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="14">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="14">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">metG</name>
        <name evidence="18" type="ordered locus">TERMP_00738</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="14"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_013467013.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00738"/>
    <dbReference type="EnsemblBacteria" id="ADT83715">
        <property type="protein sequence ID" value="ADT83715"/>
        <property type="gene ID" value="TERMP_00738"/>
    </dbReference>
    <dbReference type="GeneID" id="10041056"/>
    <dbReference type="KEGG" id="tba:TERMP_00738"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.740"/>
    <dbReference type="eggNOG" id="arCOG00810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_1_2_2"/>
    <dbReference type="OMA" id="SDMHGTP"/>
    <dbReference type="OrthoDB" id="6590at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
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    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
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        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
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    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14 16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 14 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TRNA-binding" evidence="17">
        <location>
            <begin position="631"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="14">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="14">
        <location>
            <begin position="347"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
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        <location>
            <position position="159"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
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            <dbReference type="RuleBase" id="RU363039"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ADT83715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="731" mass="85402" checksum="04376447A3BDCD7E" modified="2011-05-03" version="1">MTRYMVTSALPYANGPIHAGHLAGAYLPADIFVRYLRLKGEDVIYICGTDEHGTPITFRALKEGKSPREIVDYYYEHIKTTFERAKISFDYFGRTELPVHYKVSQDFFLRALKNGHLVKKVTKQAYCEHDKMFLPDRYVIGTCPYCGAEEQRGDQCEVCGRPLTPEILINPRCNICGNPITFKDSAHYYIKMQDFQEKLRKWIESNEHWKPNVRNTVLGWIKEGLEERAITRDLNWGIPVPLEDKEMSGKVLYVWFEAPIGYISITIEYFKRIGKEEEWKKYWLANYDGEETRIIHFIGKDNIPFHAIFWPAFLMSYGKFEDKNGEFKWLLPYDIPANEYLNLEGKKFSTSRNWAIWVHEFLDEFPADYLRYYLTAIMPETRDSDFNFKDFKAKINEELVNILGNFVHRALTFVNRYFDGKVPERGELDELDRQAFEEIEKAFEEVGELIAKYRFKDALKRAMALATFGNRYFDYQQPWKTAKTDKLRTATTVNVSLQIVKALGIIIEPFLPDAGEKIWHLLNLEELKRWEFTEIPAGHKVRKAEILFRKVTDEDIILFIVKHIARGNPESAKLLLEKYYKMEDVVRVTLENFGEKRKEEAMAILKSIYGKKFEKKERMGGGKMEYVKFDDFAKLELRIGKVVEVKDHPNADKLYVLKVDLGEEVRQLVAGLKKYYSKEELLNRYVVVIANLEPKKLRGVESQGMLLAADDGENVALLMPDKEVKLGARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL70</accession>
    <name>F0LL70_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
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    <dbReference type="STRING" id="391623.TERMP_00744"/>
    <dbReference type="EnsemblBacteria" id="ADT83721">
        <property type="protein sequence ID" value="ADT83721"/>
        <property type="gene ID" value="TERMP_00744"/>
    </dbReference>
    <dbReference type="GeneID" id="10041062"/>
    <dbReference type="KEGG" id="tba:TERMP_00744"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.746"/>
    <dbReference type="eggNOG" id="arCOG02994">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170082_0_0_2"/>
    <dbReference type="OMA" id="GIGDTEY"/>
    <dbReference type="OrthoDB" id="105481at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="113" mass="13364" checksum="C4772F28E63AFA64" modified="2011-05-03" version="1">MKAEIKEFIDRGTYRKAPLFEGELPEGSYAQIVEIKPKQTVPKHYHEKQYELFYIISGQAKLGIEEREYDAKPGDIFLVKPKTVHWVVNKKEEPFRLFVIKLNYFGDDSVWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLB0</accession>
    <name>F0LLB0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467059.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00784"/>
    <dbReference type="EnsemblBacteria" id="ADT83761">
        <property type="protein sequence ID" value="ADT83761"/>
        <property type="gene ID" value="TERMP_00784"/>
    </dbReference>
    <dbReference type="GeneID" id="10041102"/>
    <dbReference type="KEGG" id="tba:TERMP_00784"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.786"/>
    <dbReference type="eggNOG" id="arCOG07447">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200172_0_0_2"/>
    <dbReference type="OMA" id="EMTRIDY"/>
    <dbReference type="OrthoDB" id="131844at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="73" mass="8431" checksum="C76CEEC8DC79F934" modified="2011-05-03" version="1">MPGPYFPSFYPEMTRIDYLIIGFWAVLVIVVASSLYMLKRSLDALLEEVKQTNSVAQQLRDQSKHINEVLQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLC7</accession>
    <name>F0LLC7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00801"/>
    <dbReference type="EnsemblBacteria" id="ADT83778">
        <property type="protein sequence ID" value="ADT83778"/>
        <property type="gene ID" value="TERMP_00801"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00801"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.803"/>
    <dbReference type="eggNOG" id="arCOG00743">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1754802_0_0_2"/>
    <dbReference type="OMA" id="IRHDPIA"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="151" mass="17548" checksum="70B126A6C6B56B79" modified="2011-05-03" version="1">MGTAMAENDDVEKLAEELKTLRKALDELMKSFELVSQLAQNYLRLINIYAQYGELSIDIVIPEIRHDPIAREIVKIVFDLKKANISQIARELKARRGKGSRNTVREKVELLLKLNVFEMVEGEKGKCYTLRKEVINKWFDLIGIPIRFDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLE0</accession>
    <name>F0LLE0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468265.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01995"/>
    <dbReference type="EnsemblBacteria" id="ADT84969">
        <property type="protein sequence ID" value="ADT84969"/>
        <property type="gene ID" value="TERMP_01995"/>
    </dbReference>
    <dbReference type="GeneID" id="10042573"/>
    <dbReference type="KEGG" id="tba:TERMP_01995"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1992"/>
    <dbReference type="eggNOG" id="arCOG02613">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045647_5_4_2"/>
    <dbReference type="OMA" id="YGFPEND"/>
    <dbReference type="OrthoDB" id="119127at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="191" mass="21843" checksum="2469CD1868099CF9" modified="2011-05-03" version="1">MGLIEDKALVEAALFVAGRPLSVKELSKALGIKSLDYLEKLIELIAAEYAERKSAIEVVRVLGDKYVMQVKQEYSQRVIHLMPKPDLRTGELKTLALIAYLQPIEQSKIIKLRGSQAYEHIKHLLQMGLIYAEPYERTKLLGTTQKFAELYGFPENDPLLIKEAFKKVVHAEYADLIEKLEKTEKDKNRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLK1</accession>
    <name>F0LLK1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate thymidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468326.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02056"/>
    <dbReference type="EnsemblBacteria" id="ADT85030">
        <property type="protein sequence ID" value="ADT85030"/>
        <property type="gene ID" value="TERMP_02056"/>
    </dbReference>
    <dbReference type="GeneID" id="10042575"/>
    <dbReference type="KEGG" id="tba:TERMP_02056"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2053"/>
    <dbReference type="eggNOG" id="arCOG00666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_4_0_2"/>
    <dbReference type="OMA" id="WYDIGSA"/>
    <dbReference type="OrthoDB" id="36958at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="331" mass="37719" checksum="516A0F7B9B977938" modified="2011-05-03" version="1">MKVLIMAGGYATRLWPITKDNPKALLPLGDRYIIDYILEKTKELGLEVYVSTNRFFAKYFEEWSRDKDVELLVEDTFHEEEKLGTIGALQEAISKLGLDDYLIIAGDNLFSFSLKDFLDKYNGKTLIAVYDVGDFELAKRYGVVLLEGDKVIDFEEKPVKPKSTLISTGVYVFPREIMGVIPQYLEEGNKDSPGYFIQWLLSKGTEIYAYKFDEYWYDIGSADSYLEALKTLLRESYIEEIQISPYAKIISPVVIKRGAKILGRSIIGPYAYIGEGCVVENSDISDSIIFKNTIIRNSTIWRSIIDEKCEIRNLELKKSLVGGHAKIQRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLK9</accession>
    <name>F0LLK9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HGSNAT_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00809"/>
    <dbReference type="EnsemblBacteria" id="ADT83786">
        <property type="protein sequence ID" value="ADT83786"/>
        <property type="gene ID" value="TERMP_00809"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00809"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.811"/>
    <dbReference type="eggNOG" id="arCOG04370">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067755_0_1_2"/>
    <dbReference type="OMA" id="AMASYHF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012429">
        <property type="entry name" value="HGSNAT_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07786">
        <property type="entry name" value="HGSNAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HGSNAT_cat" evidence="1">
        <location>
            <begin position="14"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="254" mass="29202" checksum="0CC047FD8859F108" modified="2011-05-03" version="1">MIRMFGSEIYSSGRFWEVDLARGIGIIMMVISNFITDLQYFLNYSGHQVFWKVFAYTTASIFVFISGLSFWISYSRSIKKNPRPYKKYLRRFAKLFGLGILITITTKVLLSSGTIYFGILHFLGVASLLAIPFYRFKEKNIFFGVFFLLGSLIISKIHANTIALLPLGITPSEFFTLDYFPIFPWLGVYLFGMAMGSLLYPEGMRRFNLDFPRILPVRFVCWAGRHTLKIYIVHQPVLVGLLLLIYGSLPNLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLQ2</accession>
    <name>F0LLQ2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467127.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00852"/>
    <dbReference type="EnsemblBacteria" id="ADT83829">
        <property type="protein sequence ID" value="ADT83829"/>
        <property type="gene ID" value="TERMP_00852"/>
    </dbReference>
    <dbReference type="GeneID" id="26136301"/>
    <dbReference type="KEGG" id="tba:TERMP_00852"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.855"/>
    <dbReference type="eggNOG" id="arCOG08369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2784322_0_0_2"/>
    <dbReference type="OMA" id="ECGNINV"/>
    <dbReference type="OrthoDB" id="121066at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="73" mass="8165" checksum="BE7F1FC95EDCB46F" modified="2011-05-03" version="1">MEAQVCEYCAGRHLNEIKALLEEKKYGVEIIKCIGLCAKYGCGRINVKIGEKEISVENFDDFIKALEGVKIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLV1</accession>
    <name>F0LLV1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468346.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02076"/>
    <dbReference type="EnsemblBacteria" id="ADT85050">
        <property type="protein sequence ID" value="ADT85050"/>
        <property type="gene ID" value="TERMP_02076"/>
    </dbReference>
    <dbReference type="GeneID" id="10042391"/>
    <dbReference type="KEGG" id="tba:TERMP_02076"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2073"/>
    <dbReference type="eggNOG" id="arCOG00726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121774_2_1_2"/>
    <dbReference type="OMA" id="ANTIWKA"/>
    <dbReference type="OrthoDB" id="116013at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="138" mass="16110" checksum="2A1FC4EC2950D731" modified="2011-05-03" version="1">MIVIDSSAFSKFLLKEEGWEKVIPYLDPGLEPHAVDMLIIETTNVIWKYMKKYRLITREQAIGLYKQIRKLIGEEVIILEPSEKYLQEALKIAIEYDISIYDSLFLAQAKNLKAELITSDKRQRDVAREIGMEVVYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLV5</accession>
    <name>F0LLV5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">dTDP-glucose 4,6-dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_02080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468350.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02080"/>
    <dbReference type="EnsemblBacteria" id="ADT85054">
        <property type="protein sequence ID" value="ADT85054"/>
        <property type="gene ID" value="TERMP_02080"/>
    </dbReference>
    <dbReference type="GeneID" id="10042395"/>
    <dbReference type="KEGG" id="tba:TERMP_02080"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2077"/>
    <dbReference type="eggNOG" id="arCOG01371">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03145">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024851_0_0_2"/>
    <dbReference type="OMA" id="HNTHVDR"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="5">
        <location>
            <begin position="241"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="4">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT85054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="696" mass="80420" checksum="6B53A73352FF17D7" modified="2011-05-03" version="1">MRVLVTGGAGFIGSNFIRYILEKHKDWEVINLDKLGYGSKLANLKDIENDPRYTFVKGDINDFELVKGIIKKVDAVVNFAAESVAENEFVAIHRHGRIRLVTFGELFEELSKTNKVIRDGKHEIIDVSGKNIKVLSFYNGYGAWFPLKKIIRHYYKGKLICLRQKWGEIYVTPNHSVYDVFGNLVSAESNPELLAIRRINYYPHEHKFKSPISTRAERNGHLRVTLDKVYTGKKLEALLRLLAAYISEGNATYNKANGSYSVVINNRDRDWLELLAEDYMLISNGSYSITKRKDSVYQLELKSKEFYQMCTDLCGKNAPEKRLPDFVYGLDRKYQIMFWETLLKGDGTYRKWSRDKTAEYTTVSRRLAAGLGLLLALMGIDYTYYISKPRRGNYTSYTIRTRLFYNVSTGKRELIEVEYEGYVYDLEVEKSHNFIAGVGNIVAHNTHVDRSISNPYAFIESNVLGVYTILEAIRKYNPEVRLVHVGTDEVYGDIIEGSFTEEDRLMPSSPYSASKAAGDMLVLGYARTYNLNASITRCTNNYGPYQFPEKLIPKTIIRASMGLKIPIYGTGQNVRDWLYVTDHCEAVELVLEKGEKREVYNISAGEEKTNLEVVKTILKLMGKDEDLIEFVEDRPGHDLRYSLDSTKIREQLGWKPKHNFKEGIKKTVEWYLSNEWWWRPLVDEKVLHPTPWKLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLW0</accession>
    <name>F0LLW0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468355.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02085"/>
    <dbReference type="EnsemblBacteria" id="ADT85059">
        <property type="protein sequence ID" value="ADT85059"/>
        <property type="gene ID" value="TERMP_02085"/>
    </dbReference>
    <dbReference type="GeneID" id="10042400"/>
    <dbReference type="KEGG" id="tba:TERMP_02085"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2082"/>
    <dbReference type="eggNOG" id="arCOG02217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175270_0_0_2"/>
    <dbReference type="OMA" id="KYVREDR"/>
    <dbReference type="OrthoDB" id="131018at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039709">
        <property type="entry name" value="VapB3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42244">
        <property type="entry name" value="PTHR42244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="73" mass="8804" checksum="EE6A40232C837A91" modified="2011-05-03" version="1">MEVVSFRIPPELKKKMKDVDINWSEEIRKFIEAKVREYRKKKALEEIDMMLANLSKTEKGTARKYLREDRDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLY9</accession>
    <name>F0LLY9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4350 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468384.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02114"/>
    <dbReference type="EnsemblBacteria" id="ADT85088">
        <property type="protein sequence ID" value="ADT85088"/>
        <property type="gene ID" value="TERMP_02114"/>
    </dbReference>
    <dbReference type="GeneID" id="10042429"/>
    <dbReference type="KEGG" id="tba:TERMP_02114"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2111"/>
    <dbReference type="eggNOG" id="arCOG01314">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069303_0_0_2"/>
    <dbReference type="OMA" id="YIDEAHH"/>
    <dbReference type="OrthoDB" id="57955at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025646">
        <property type="entry name" value="DUF4350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14258">
        <property type="entry name" value="DUF4350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4350" evidence="2">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="336" mass="37857" checksum="98AC681A07D5EC53" modified="2011-05-03" version="1">MRRVIYGLLITFGIFLLIMPLSIPIFTSSTDFSIFNTKWNGASSFGKVLYDNSKIIPIISPFNSIELGKKRGTLLILGPDMGYSTLEIDEIKKFLENGGTLVLIDDFGTGNQILKGLNLTARFSKVSFIDVFYSKNYNFPELVRILDPELGAGVDKLVLNVPSVILNAEGEIYTSKVALLGNNQREYPIMSELKYGKGKIVLFSDPSVFINDMFRENEKFIRNFAEYISSDVVYIDEAHHSSFNPYHMATLVIRRSFDRVKAFYVVLGVAVLALVIESGFAASLAEKSLTFLFNKLFKEEEKSLDEVINELKEEGYDEEVLRKIVREIKTGKKLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM25</accession>
    <name>F0LM25_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps15</name>
        <name evidence="7" type="ordered locus">TERMP_00896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467170.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00896"/>
    <dbReference type="EnsemblBacteria" id="ADT83872">
        <property type="protein sequence ID" value="ADT83872"/>
        <property type="gene ID" value="TERMP_00896"/>
    </dbReference>
    <dbReference type="GeneID" id="26136341"/>
    <dbReference type="KEGG" id="tba:TERMP_00896"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.897"/>
    <dbReference type="eggNOG" id="arCOG04185">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090139_2_0_2"/>
    <dbReference type="OMA" id="EEHPKDM"/>
    <dbReference type="OrthoDB" id="98179at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_S15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_S13/S15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_S15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="PTHR11885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S13_N" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="151" mass="17644" checksum="AB2D6F7F0C5769E8" modified="2011-05-03" version="1">MARIHARKRGKSGSKRPPRTAPPTWVEYTAEEVENLVIKLRKEGYSTAMIGTILRDQYGIPSVKLITGKKITKILEENGLAPEIPEDLMFLIKRAVNLRRHLEEHPKDIHSRRGLQLIESKIRRLVKYYRRTGKLPPKWRYDPEQAKLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM28</accession>
    <name>F0LM28_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S3Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosomal protein S1e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps3ae</name>
        <name evidence="5" type="ordered locus">TERMP_00899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467173.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00899"/>
    <dbReference type="EnsemblBacteria" id="ADT83875">
        <property type="protein sequence ID" value="ADT83875"/>
        <property type="gene ID" value="TERMP_00899"/>
    </dbReference>
    <dbReference type="GeneID" id="10041216"/>
    <dbReference type="KEGG" id="tba:TERMP_00899"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.900"/>
    <dbReference type="eggNOG" id="arCOG04186">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062507_1_0_2"/>
    <dbReference type="OMA" id="GQNAYTK"/>
    <dbReference type="OrthoDB" id="96138at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00359">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030838">
        <property type="entry name" value="30S_S3Ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_S3Ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_S3Ae_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="200" mass="23197" checksum="BB463877CC375A01" modified="2011-05-03" version="1">MARANPRKRAAAARDKWKLKQWYIVYAPEFFGSQEIGLTPADDPEKVKGRVIETTLKDLTGDFTKGHVKLYFQIYDVKGQNAYTKFKGHKLARSYIRSLVRRRTTRIDGIFNVTTKDGYKLRVMGMVIAIRRIQTSQERAIREIMRNIIYKKAEELPFTQFVLEAVTGKMASEIAKEAKKIYPLKRAEIRKIKVLAEPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM84</accession>
    <name>F0LM84_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467229.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00955"/>
    <dbReference type="EnsemblBacteria" id="ADT83931">
        <property type="protein sequence ID" value="ADT83931"/>
        <property type="gene ID" value="TERMP_00955"/>
    </dbReference>
    <dbReference type="GeneID" id="10041272"/>
    <dbReference type="KEGG" id="tba:TERMP_00955"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.958"/>
    <dbReference type="eggNOG" id="arCOG05092">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134280_4_0_2"/>
    <dbReference type="OMA" id="IAINERY"/>
    <dbReference type="OrthoDB" id="120805at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019277">
        <property type="entry name" value="DUF2304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10066">
        <property type="entry name" value="DUF2304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="121" mass="14098" checksum="8A16E5771AF9EA0F" modified="2011-05-03" version="1">MLAVQYIAIVTILGLMIYVLSKYGRRELEWKDFLFWEILLLIMLIITLKPIEISLEIKRVLGLGRGLDALFVVAIGISYLMIFKVYLAVDKAEREITELTRKIAIELREINEKLEEIKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM98</accession>
    <name>F0LM98_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Drug/metabolite transporter (DMT) permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
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            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
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        <source>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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</entry>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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        </source>
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</entry>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMF6</accession>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="306" mass="35125" checksum="FE6C20816301EA48" modified="2011-05-03" version="1">MDIRIAKLEDTRGIVDVHCSDIGEWYHYENGQRREPDSYDNLTLKERYLHGGPWMSIETCAIHLNNLLLNGQIPLVAEIEGRIVGELELFISKELINGRTRKVAHIDVLEVHREFRGQGIGRELVKAAEELARKEKCELLTVTPEKEAVGFYEKVGIKDILHKGCFISLNLSMLPNKDAKEINIREFSWKEVKDKEMILGKFQSSYDHWFTPFKDRIAGIDDALYFESGQIGGSYYILEGSFFGKDIATVYAWGDNIEELILQIGSRAKELGFREIRTSISEKDLEKIQAFQPKVLDRFVILAKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMK6</accession>
    <name>F0LMK6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467283.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01009"/>
    <dbReference type="EnsemblBacteria" id="ADT83985">
        <property type="protein sequence ID" value="ADT83985"/>
        <property type="gene ID" value="TERMP_01009"/>
    </dbReference>
    <dbReference type="GeneID" id="10041326"/>
    <dbReference type="KEGG" id="tba:TERMP_01009"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1012"/>
    <dbReference type="eggNOG" id="arCOG05115">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168730_0_0_2"/>
    <dbReference type="OMA" id="HVYVKID"/>
    <dbReference type="OrthoDB" id="116605at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="116" mass="13085" checksum="15F2D6431B9C1887" modified="2011-05-03" version="1">MKKMVTIIVLLIVGGAIATWSHIKEEKRVVVLQATFKMGGITYEGYKIQGDTLIFEFKRTGDVFTQAIVKKEVKVGIEDFPARVVVEVNTNGNVKRYEAELIFDGDDERVYKASEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMM5</accession>
    <name>F0LMM5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane-bound ClpP-class protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467302.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01028"/>
    <dbReference type="EnsemblBacteria" id="ADT84004">
        <property type="protein sequence ID" value="ADT84004"/>
        <property type="gene ID" value="TERMP_01028"/>
    </dbReference>
    <dbReference type="GeneID" id="10041345"/>
    <dbReference type="KEGG" id="tba:TERMP_01028"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1031"/>
    <dbReference type="eggNOG" id="arCOG01910">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024619_1_0_2"/>
    <dbReference type="OMA" id="QMDTPGG"/>
    <dbReference type="OrthoDB" id="38523at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="353"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="449" mass="48738" checksum="664B59749EDB7B6D" modified="2011-05-03" version="1">MRKVLLIVALFILLTPALAQAKTVYVAQIKGQITSYTYDQFDRYISEAERANANAIIIELDTPGGRGDAMQNIIQRIQTAKVPVIIYVYPSGAMAASAGTYIALGSHLIAMAPGTGIGACRPILGYSQNGSIIEAPAKITNFYVAYIKSLAEASGRNATIAEKFITEDLSLTPEEALKYHVIEVIAYDLNDLLNKADGMKTKLPVNGKYVTLSLKDAQVVYLRPTFKDQLITYITDPVVAYVLLTLGIWALILGFLSPGWHVPETAGAIMIALAIIGLGYFGYRSAGLLLIFLAIIFFIAEALTPTFGLFTVAGFISFVIGSIFLFSGGGGVDYLVSREVYSQLRLVIITIGILLAVFFAFGMAAVIRAHRRKAQTGKEEMIGLEGEVIEPLVPEGMIKIRGELWKAVSKTGEEINIGKKVRVVGMEGLKLIVVREKEKNVEEESKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMQ2</accession>
    <name>F0LMQ2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smc</name>
        <name evidence="5" type="ordered locus">TERMP_01055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01055"/>
    <dbReference type="EnsemblBacteria" id="ADT84031">
        <property type="protein sequence ID" value="ADT84031"/>
        <property type="gene ID" value="TERMP_01055"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01055"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1058"/>
    <dbReference type="eggNOG" id="arCOG00371">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_2_2_2"/>
    <dbReference type="OMA" id="HNKIAME"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02169">
        <property type="entry name" value="SMC_prok_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="4">
        <location>
            <begin position="520"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="169"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="659"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1087" mass="125998" checksum="AA0287D6F9F22E15" modified="2011-05-03" version="1">MPYIEKLEMKGFKSYGSRKVVVPFSKGFTAIVGANGSGKSNIGDAILFVLGGLSAKAMRATRISDLIFAGTKKEPPAKYAEVTIYFNNEDRGFPVDEDEVVIKRRVYPDGRSTYWLNGKRTSRSDILDILSAAMISPEGYNLVLQGDITKFIKMSPVERRMIIDEISGIAEYDAKKKKAMEELKQAEENLARVDLLIHEVKKQLDKLEKERNDALRYLDLKEKLEKAKVTLLVGEIKRLEKLIKESEERDKQIEKEAKEVEDKLKEIVKGILEKENLLAKIERELEEKSEDGILELTRKISDVKSKIEMAKKNIELAKKEIEESQRRLIKSKEELKKISEEIEKSKSAIQRWSKRKEKLLKEIEEKEKERNELIVKLGEIDKNFTIAKQEFDKVTEELENAKRDFYMKESDIKKFEEEIERLKSKIVQNNAKRLTLKNKIADLKTRIDEKKAELGEIEGKMQKRESQLRKVEKELEEKQQKLQKSIPELEKVKQELIRAEAQKEVSKNRALEALKKANIPGVYGSLAELIRIKDDNYFVAIDVALGSHADNVIVEDDRVAEKAIKFLKENRLGRLTFLPLNKIKPRSLKEAPLGIPAMDVVEYDPKFRNAVAFALGDTLIVNDMDEARGVGIGKVRMVTLGGELLERSGAIVGGYYKPRARLAVNTEELKKKVEALEREKEKLESEINALKVEYRGLERELFELRMKKSNVSKDLDVLQTEMDRLLKEDKLLSEEIKESEELIKALEKKIYDTKGELAKLKGKIERLEKKKDKLKKALDNPEARELNQKIREVEHEISKLREELSKVESKLESLDVRINEELLPRKADLEEEIEGLVNRINAFKQSIAKNEEDIAKLQEELKKLEEQESAVREELKALRDKREELKKEIIQLREEKDKLNNRLQELRIEANTLKIKIAQYNTQLQEKNRELKHHDTKLVKEIPLDLEKLREEIEQMEEEIKELEPVNMKAIEDFEIVERRYMELKSKRERLEAEKESILEFIDEIEAQKKNVFMTTLNAIARNFSELFAKLSPGGSARLILENPDDPFSGGLKLKQSCWKGGKENRSNERWRESFDGFGIRLCNPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMQ8</accession>
    <name>F0LMQ8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="1">dTTPase/UTPase</shortName>
            <ecNumber evidence="1">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="1">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467335.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01061"/>
    <dbReference type="EnsemblBacteria" id="ADT84037">
        <property type="protein sequence ID" value="ADT84037"/>
        <property type="gene ID" value="TERMP_01061"/>
    </dbReference>
    <dbReference type="GeneID" id="10041378"/>
    <dbReference type="KEGG" id="tba:TERMP_01061"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1064"/>
    <dbReference type="eggNOG" id="arCOG05007">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_0_2_2"/>
    <dbReference type="OMA" id="RIDGDFY"/>
    <dbReference type="OrthoDB" id="93677at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="186" mass="21179" checksum="2EB1F23468110FC4" modified="2011-05-03" version="1">MFILASQSPRRREILERFFENFKVVPSNADENVIEENPREKAIEVARKKAWEVYNRVGGTVVGADTIVVLENKVLGKPKNEKEAEKMLKLLSGKTHEVITGYCIIHEGKEITGFEVTKVKFRDLSEEEIEWYVSTGEPLDKAGAYAIQGKAAIFIEWIYGDFYNVVGLPIKVVLELKKLGFPLKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMT9</accession>
    <name>F0LMT9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L39e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl39e</name>
        <name evidence="6" type="ordered locus">TERMP_01092</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467366.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01092"/>
    <dbReference type="EnsemblBacteria" id="ADT84068">
        <property type="protein sequence ID" value="ADT84068"/>
        <property type="gene ID" value="TERMP_01092"/>
    </dbReference>
    <dbReference type="GeneID" id="26136547"/>
    <dbReference type="KEGG" id="tba:TERMP_01092"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1095"/>
    <dbReference type="eggNOG" id="arCOG04177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181948_4_0_2"/>
    <dbReference type="OMA" id="KMRYWRR"/>
    <dbReference type="OrthoDB" id="131584at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_L39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020083">
        <property type="entry name" value="Ribosomal_L39_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_L39e_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="SSF48662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00051">
        <property type="entry name" value="RIBOSOMAL_L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="51" mass="6311" checksum="C8717A9A159553E4" modified="2011-05-03" version="1">MARYKPLAKKLRLAKAAKQNRRVPVWVIVKTNRRVITHPKRRYWRRTKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMV8</accession>
    <name>F0LMV8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467385.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01111"/>
    <dbReference type="EnsemblBacteria" id="ADT84087">
        <property type="protein sequence ID" value="ADT84087"/>
        <property type="gene ID" value="TERMP_01111"/>
    </dbReference>
    <dbReference type="GeneID" id="26136562"/>
    <dbReference type="KEGG" id="tba:TERMP_01111"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1114"/>
    <dbReference type="eggNOG" id="arCOG02155">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174517_0_0_2"/>
    <dbReference type="OMA" id="DYIVVQR"/>
    <dbReference type="OrthoDB" id="112213at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="101" mass="11278" checksum="3B9FF30E0FD96F7A" modified="2011-05-03" version="1">MVKIKASKLRDVELITDTGIRLGWVYDLSFDEETGDLLVIVAEPDEDLDTSEFVTDHEGLLLIPISAVKSIGEVIIIDSSKLAVKSKLRRLRTVKERVQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN08</accession>
    <name>F0LN08_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Arylmalonate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467435.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01161"/>
    <dbReference type="EnsemblBacteria" id="ADT84137">
        <property type="protein sequence ID" value="ADT84137"/>
        <property type="gene ID" value="TERMP_01161"/>
    </dbReference>
    <dbReference type="GeneID" id="10041478"/>
    <dbReference type="KEGG" id="tba:TERMP_01161"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1164"/>
    <dbReference type="eggNOG" id="arCOG02004">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068086_5_1_2"/>
    <dbReference type="OMA" id="NTTMEME"/>
    <dbReference type="OrthoDB" id="75709at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015736">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="237" mass="26743" checksum="28CC6A872E74BCDD" modified="2011-05-03" version="1">MYGWRGRIGLIVPSSNTTMEMELHSALPEGVSLHTARMPLKGITEEELLKMSSLAIDSARLLKDADVDLILYGCTSGSFIGGINFEAELEEKIEREVNIPVVTTSTAVIEALKILDAQQIMVITPYTDEINQREKEFLEANEFEVLDIRGLGIVDNVQVGKLEPYEAYRMAKAMFIDDVDAVFISCTNLRTFEIIEPLEEDLGVPVVTSNQASLWLVLRELDIRERIPWLGRLFMEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN35</accession>
    <name>F0LN35_THEBM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01188"/>
    <dbReference type="EnsemblBacteria" id="ADT84164">
        <property type="protein sequence ID" value="ADT84164"/>
        <property type="gene ID" value="TERMP_01188"/>
    </dbReference>
    <dbReference type="GeneID" id="10041505"/>
    <dbReference type="KEGG" id="tba:TERMP_01188"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1191"/>
    <dbReference type="eggNOG" id="arCOG04458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1381451_0_0_2"/>
    <dbReference type="OMA" id="VLHITWD"/>
    <dbReference type="OrthoDB" id="89533at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007386">
        <property type="entry name" value="DUF447"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016733">
        <property type="entry name" value="UCP018747"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04289">
        <property type="entry name" value="DUF447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018747">
        <property type="entry name" value="UCP018747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="203" mass="23415" checksum="5B4D899A10D8C8D2" modified="2011-05-03" version="1">MEILDLFEEGKVYEVLLVTKSNVTPIGVVRRGDSLYFKLFWGKSFREIKEHPFGVIHITQDVELLIKAALNIPINAEFENTKVIPLKRIKNLSWVEGRIELKEAEIEDELGKSKVLKCKFIPLYGEIISAITKPLSRADFVLLEMAVHLTRLFVATRRHKVETAQKLYSKIWQGYQEYRRLGGKSELAEKIMGLALISVRWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN85</accession>
    <name>F0LN85_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
            <plasmid evidence="2 3">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747446.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02251"/>
    <dbReference type="EnsemblBacteria" id="ADT85224">
        <property type="protein sequence ID" value="ADT85224"/>
        <property type="gene ID" value="TERMP_02251"/>
    </dbReference>
    <dbReference type="GeneID" id="10549075"/>
    <dbReference type="KEGG" id="tba:TERMP_02251"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2245"/>
    <dbReference type="eggNOG" id="arCOG00373">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_992554_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="280" mass="32693" checksum="58841B6524133CF9" modified="2011-05-03" version="1">MKWHIGIGAIVFATLLVVSQVTPHDTTQETILMPLLQQLDDIHKDINKSITQMQTLKSSQESLNQIILQQQKEIQSLHAQLHKFNQTLRELEHVINTTAQRTEFKLMELEQIIEHTNENTNLVLRKISNNKNQTLPIEEKDIYKNGTAFTNLDIKEKLKEIFPKAKIITSDIVYITPPIENIDKLEIFINWTKIPELEYKAELNDCDDFAWRLYSESKTHYSLLALGVAYSKNHVFNIIIFKINSTNQLSVYIIEPQTGSIFPFNETLPEYYREIEYVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGU1</accession>
    <name>F0LGU1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">TERMP_00002</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466278.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00002"/>
    <dbReference type="MEROPS" id="M50.A07"/>
    <dbReference type="EnsemblBacteria" id="ADT82980">
        <property type="protein sequence ID" value="ADT82980"/>
        <property type="gene ID" value="TERMP_00002"/>
    </dbReference>
    <dbReference type="GeneID" id="10040321"/>
    <dbReference type="KEGG" id="tba:TERMP_00002"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2"/>
    <dbReference type="eggNOG" id="arCOG00614">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099718_0_0_2"/>
    <dbReference type="OMA" id="SEFRAWY"/>
    <dbReference type="OrthoDB" id="118207at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADT82980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="194" mass="21984" checksum="00DFAD5B6BC3FFCF" modified="2011-05-03" version="1">MIKDFKRQELEDLAISYIVLLILFSNFEIKNMPYVALAVLTAFVFHELAHRQVAKKYGYIAFYKRWDTGIVIALLLGIAGKIIFGHAIFFAALGAVYIYAPYQYWEDKEAEGWISLSGPLTNIIVGIVALILLKTLSLPLHALISLFYTAIVNFWIAFFNLLPFPPLDGYKVLKWNAGYWAVAIGIAYVLRSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGY7</accession>
    <name>F0LGY7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01219"/>
    <dbReference type="EnsemblBacteria" id="ADT84195">
        <property type="protein sequence ID" value="ADT84195"/>
        <property type="gene ID" value="TERMP_01219"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01219"/>
    <dbReference type="eggNOG" id="arCOG04026">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_205638_3_0_2"/>
    <dbReference type="OMA" id="KMMRAQT"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007166">
        <property type="entry name" value="Class3_signal_pept_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04021">
        <property type="entry name" value="Class_IIIsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="54" mass="6035" checksum="37861C9FBAB87B0B" modified="2011-05-03" version="1">MRRAQSALEYLFMVAVALILVAITLRVILSSVRSINGVISNYTATIREEIIQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH47</accession>
    <name>F0LH47_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466307.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00031"/>
    <dbReference type="EnsemblBacteria" id="ADT83009">
        <property type="protein sequence ID" value="ADT83009"/>
        <property type="gene ID" value="TERMP_00031"/>
    </dbReference>
    <dbReference type="GeneID" id="26137883"/>
    <dbReference type="KEGG" id="tba:TERMP_00031"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.30"/>
    <dbReference type="eggNOG" id="arCOG00202">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="DIVPLYC"/>
    <dbReference type="OrthoDB" id="92866at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005876">
        <property type="entry name" value="Co_trans_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01166">
        <property type="entry name" value="cbiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="263" mass="29538" checksum="9405710223C934CD" modified="2011-05-03" version="1">MIEIKSLHFSYGEREILRDINLEIKKGEIFGLLGPNGAGKSTLILHLNGILKPKKGEILVDGLNPVENPREVRKKVGIVFQDPNDQLFSPTVFEDVAFGPYNLGLRGKELEEKVYEALKVVGMESYADREIKHLSFGEKKRIAIATVLAMDPEILVFDEPFANLDFRGKEQVRTLIEQFRGEKTIILASHEAEYLTLCDRIALIDKGQIIKVGTPEDILGDVELLKAHNLEVPPLIELFLSLGLGMPKNLEDAIEMLRLRNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH55</accession>
    <name>F0LH55_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Translation initiation factor 5A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Hypusine-containing protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">eIF-5A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">eif5a</name>
        <name evidence="13" type="ordered locus">TERMP_00039</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Functions by promoting the formation of the first peptide bond.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466315.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00039"/>
    <dbReference type="EnsemblBacteria" id="ADT83017">
        <property type="protein sequence ID" value="ADT83017"/>
        <property type="gene ID" value="TERMP_00039"/>
    </dbReference>
    <dbReference type="GeneID" id="10040358"/>
    <dbReference type="KEGG" id="tba:TERMP_00039"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.38"/>
    <dbReference type="eggNOG" id="arCOG04277">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102600_3_0_2"/>
    <dbReference type="OMA" id="QIMDMET"/>
    <dbReference type="OrthoDB" id="98221at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00085">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022847">
        <property type="entry name" value="Transl_elong_IF5A_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="Transl_elong_IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="PTHR11673"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 11 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF-5a" evidence="12">
        <location>
            <begin position="70"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="modified residue" description="Hypusine" evidence="11">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT83017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="136" mass="15039" checksum="C8B16286D2F2F4A6" modified="2011-05-03" version="1">MGDKTKVQVSKLKPGRYIIIDGEPCRIVNITVSSPGKHGSAKARIEAVGVFDGKVRSIVKPTSAEVDVPIIDKRTGQIIAITPDTVQLMDMETYELFDVPIETGVNDEIKDQLKEGINVEYWETLGRVKIMKIKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH73</accession>
    <name>F0LH73_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466333.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00057"/>
    <dbReference type="EnsemblBacteria" id="ADT83035">
        <property type="protein sequence ID" value="ADT83035"/>
        <property type="gene ID" value="TERMP_00057"/>
    </dbReference>
    <dbReference type="GeneID" id="26137910"/>
    <dbReference type="KEGG" id="tba:TERMP_00057"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.57"/>
    <dbReference type="eggNOG" id="arCOG05793">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1406026_0_0_2"/>
    <dbReference type="OMA" id="HWLRIDE"/>
    <dbReference type="OrthoDB" id="68233at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="197" mass="22717" checksum="ABA9488B6CA772ED" modified="2011-05-03" version="1">MGVYIFTPEDLLRYGNITNEQLETIKNALLRKSDILVVGASRAGKTKLIEAMVHLIPDEWKIAVVTAYNEFKPFKENIEIINTEFDKKSVRTRTKEVIGEIKKLNPDYVVIDTLHTINVPLILGELIDDYAFIISSLILSRDVVSEVKHWLKIDDETLKRFELVIELYRDIKEGARKVNAIYKVVEEGKKIKLEKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH77</accession>
    <name>F0LH77_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466337.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00061"/>
    <dbReference type="EnsemblBacteria" id="ADT83039">
        <property type="protein sequence ID" value="ADT83039"/>
        <property type="gene ID" value="TERMP_00061"/>
    </dbReference>
    <dbReference type="GeneID" id="10040380"/>
    <dbReference type="KEGG" id="tba:TERMP_00061"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.61"/>
    <dbReference type="HOGENOM" id="CLU_688151_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="400" mass="46453" checksum="BA5AB6256FBD1DB6" modified="2011-05-03" version="1">MKLFKLFLLFLLFILVSVVIINQNTQEQKNKNEFSNVTSNDIFIHSFEHLENKTPLEGEFKPILTLPAWDFQGFEDRLFVYYNGTLKVYNVKSGKLLLNVTPVYDYYFSNRYAYIKTDNGSFVLDYETLRLAPIDTDKNVEYAFNLGNCRITAREKSILVNSQVFTFNSTPKVAFFPNGFVVYGLYKDRETRVIFFDERCNILNDTIISNYPLVCKVVDHKIFFIRRGLFAVNQSKFPKLKGEQVLHEYLSMSSVYLFNSKGQEIASLGMGGIIGFYNNTLYSFKVNPDYCDELIKFYLSNKSLKKQCFRVSHYSGWFVSQGTFGDFGDGFMAFAYWGFSGESGTAYNYLCVYVYDKRLNCIPYYSGTKRVSPIDEIKAWDRYFAIVPRGSEEVVVYEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHC6</accession>
    <name>F0LHC6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-aminobutyrate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467551.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01278"/>
    <dbReference type="EnsemblBacteria" id="ADT84253">
        <property type="protein sequence ID" value="ADT84253"/>
        <property type="gene ID" value="TERMP_01278"/>
    </dbReference>
    <dbReference type="GeneID" id="10041594"/>
    <dbReference type="KEGG" id="tba:TERMP_01278"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1280"/>
    <dbReference type="eggNOG" id="arCOG00916">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_2"/>
    <dbReference type="OMA" id="GMTTQIY"/>
    <dbReference type="OrthoDB" id="20774at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="443" mass="49526" checksum="F403948960F7EDE0" modified="2011-05-03" version="1">MKRDEIISRYSKVFPKAARVTYAPIVGVKAKNAKVWDIEGREYIDFLSDAAVQNVGHNNDRVVKAIKEQTDRLVHFTFIYGFPIEPLLLAEKLVEISPIKSAKVVLGLSGSDANDGAIKFARAYTGRRTLLGYLGSYYGATYGAMSITGLDFEIRALVGELSDIHYIPFPDCYRCPFGQERGKCHFECISYLEYKFEREVYAEGVAALFAEPIQGDAGMIVPPDDYFRKLKKILDEYGILLVVDEVQSGLGRTGKWFAIEHFGVTPDIITIAKPLGGGLPISAIIGRGEIMESLPALGHTFTLSGNPVTSRAALAVIEEIEEKNLLKRAEELGEYTMRRLKKMQKEHELIGDVRGKGLMIGIDLVKNRETKERAFDEAKKVVWRAYELGLILAFLHGNVLRIQPPLTIEKELLDEGLDKLEQAIEDVENGKVDDKVLKIVKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHD8</accession>
    <name>F0LHD8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">OMP decarboxylase</fullName>
            <shortName evidence="5">OMPDCase</shortName>
            <shortName evidence="5">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrF</name>
        <name evidence="8" type="ordered locus">TERMP_01290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the OMP decarboxylase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467563.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01290"/>
    <dbReference type="EnsemblBacteria" id="ADT84265">
        <property type="protein sequence ID" value="ADT84265"/>
        <property type="gene ID" value="TERMP_01290"/>
    </dbReference>
    <dbReference type="GeneID" id="10041606"/>
    <dbReference type="KEGG" id="tba:TERMP_01290"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1292"/>
    <dbReference type="eggNOG" id="arCOG00081">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067069_2_0_2"/>
    <dbReference type="OMA" id="EMSHPGA"/>
    <dbReference type="OrthoDB" id="54384at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01200_A">
        <property type="entry name" value="OMPdecase_type1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="PTHR32119:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="209" mass="22997" checksum="65B76FB5D35874D8" modified="2011-05-03" version="1">MIILALDVYERKRALKIAEETKDYLWAIKINWPLILGSGIGIIGELKEKTGLPVIADLKVADIPNTNKLIAKKVFDNGADYIIVHGFVGRDSVRAVMEEGSTIIVVEMSHPGAEEFMQPITDRLIEMANELKPFGVVAPGTRPERIRYIREKLDGDIKIFTPGIGAQGGKAKEALKAGADYIIVGRAIYNADNPREAVKSLWGELNAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHK4</accession>
    <name>F0LHK4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl19e</name>
        <name evidence="9" type="ordered locus">TERMP_00110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00110"/>
    <dbReference type="EnsemblBacteria" id="ADT83088">
        <property type="protein sequence ID" value="ADT83088"/>
        <property type="gene ID" value="TERMP_00110"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00110"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.111"/>
    <dbReference type="eggNOG" id="arCOG04089">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083919_1_1_2"/>
    <dbReference type="OMA" id="NRVWIDP"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01418">
        <property type="entry name" value="Ribosomal_L19e_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_L19/L19e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_L19/L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_L19/L19e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_L19/L19e_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033936">
        <property type="entry name" value="Ribosomal_L19e_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="RPL19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="PTHR10722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="SSF48140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L19e" evidence="8">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="150" mass="17999" checksum="5141B55AED9B72B4" modified="2011-05-03" version="1">MIIMRMQRRIAAEILKCGENRIWIDPERIEDVKSAITREDIKRLIKEGVIKKKPVKGQSTYRAKIRHEQRKKGRHRGPGSRKGKKTARMGKKERWIMTIRALRKELRKLKAEKKIDVHTYRRLYIRAKGGQFKNKHQLYLFLEEKGILKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHS5</accession>
    <name>F0LHS5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466457.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00182"/>
    <dbReference type="EnsemblBacteria" id="ADT83159">
        <property type="protein sequence ID" value="ADT83159"/>
        <property type="gene ID" value="TERMP_00182"/>
    </dbReference>
    <dbReference type="GeneID" id="10040500"/>
    <dbReference type="KEGG" id="tba:TERMP_00182"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.183"/>
    <dbReference type="eggNOG" id="arCOG01772">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055583_0_0_2"/>
    <dbReference type="OMA" id="WTPCISL"/>
    <dbReference type="OrthoDB" id="76035at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="402" mass="45283" checksum="E3CBC361156E97F9" modified="2011-05-03" version="1">MKVGVVFGVSEIADPKRFEKKASQFLTKLSEEFEVVGGTFISTKKEFKDLKEEIDFNKVDAIVLYPLTGGTENPLKEFAIYRKPVILFGDSFNNSIAAAVEIREYLRDRLIPSTLVTSYEELKAALLGYDDMKEILDKFLNLRLGLIGRISPWLINEKFELPYVHISLKKFYEYYESVTEAEGWKVIEDVIAKAREIKEPNREDLVKAGRIYVALKRIIEDYKLDGFTIGCFDLIGKIKATPCLALALFNAEGIPAACEGELNSLLGMAIIRKFFNKPAFMGNIADYGEDYIILAHCTAPLIAGYTLRSHFESGMGVGVEVDLPRKKASLLKIRGRKAVVASVMVAEREKSEQRCRTQLKLKIEDAKDFVDGTLGNHHLLVYADSEELADLLSELGFEVMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHU8</accession>
    <name>F0LHU8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467646.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01373"/>
    <dbReference type="EnsemblBacteria" id="ADT84348">
        <property type="protein sequence ID" value="ADT84348"/>
        <property type="gene ID" value="TERMP_01373"/>
    </dbReference>
    <dbReference type="GeneID" id="10041689"/>
    <dbReference type="KEGG" id="tba:TERMP_01373"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1373"/>
    <dbReference type="eggNOG" id="arCOG05802">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1700361_0_0_2"/>
    <dbReference type="OMA" id="PSDYGLR"/>
    <dbReference type="OrthoDB" id="89691at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="154" mass="17922" checksum="9E235A465165881C" modified="2011-05-03" version="1">MLGFLKRKKKEKFGPLIYLSEPTIIYHTQTEKVILKILEEKLGSNNVVLPSDYGLKGTSHMIKDAEFFVAVAIIGKFTSLVVNEIKIAQELGKKIYTLNIARKGEEVEYIFTEGIPDDIEWLTPKETNQLYEDFRGEEFSGFMKFFFGDRRREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHX6</accession>
    <name>F0LHX6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lead/cadmium/zinc and mercury transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467674.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01401"/>
    <dbReference type="EnsemblBacteria" id="ADT84376">
        <property type="protein sequence ID" value="ADT84376"/>
        <property type="gene ID" value="TERMP_01401"/>
    </dbReference>
    <dbReference type="GeneID" id="10041717"/>
    <dbReference type="KEGG" id="tba:TERMP_01401"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1401"/>
    <dbReference type="eggNOG" id="arCOG01576">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02763">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_2_2"/>
    <dbReference type="OMA" id="FAQPWET"/>
    <dbReference type="OrthoDB" id="21472at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00941">
        <property type="entry name" value="CDATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="7">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="691" mass="76151" checksum="03B389531649507B" modified="2011-05-03" version="1">MPKKLKLEGLDCASCAYEIEEALKKEGFEFALVNFTTKEAIIEGDIEKAKEIIKKVEPGVKIIEKEEHEHDHHHDHDDPKRMLYFIIPSLLLFAIGIVLRYYYNYDNPFVFGIFVVSYLLVGWKVLRNAFVNSIHGNVFDENFLIAIATLGAFAIHEYPEAVGVMLFYIVGEFFQDLAVNRSRRSIKALLALKAEYANLKVGDKIVRVKPEELKVGDIIVIKPGERVPVDGVIIEGSSSVDTSALTGESVPRTVKEGDEILSGMVNLSGLLTVKVTKELKESTISRILELVENASARKAKTEKFITRFAHYYTPAVVGLAMLIALVPPLVFGEPFSKWVYRALVLLVISCPCALVLSIPLGYFGGIGRAARDGILVKGSNFLDALSRAAIVAFDKTGTLTKGVFKVTKIETRNGFSEDEILRFAALAEAHSNHPIAKAIREAYGEEINEAEIKEYEEIAGHGVRAKIDGVEVMVGNDRLLHRFNIEHDTCRVKGTVAHVVINGKYAGYIIISDEIKDDAPLAVKELKRLGIKKVVMVTGDNRDVAEEIARQIGLDGFYAELLPEDKVKVIEELEKEKAPNEKIVFVGDGINDAPVLARADVGVAMGALGSDAAIETADVVIMDDKPSKLPRGIRIARKTQRIVWQNIIFALGVKLAFIGLGILGEATMWEAVFADVGVALIAVFNAMRILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI18</accession>
    <name>F0LI18_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Acidic ribosomal protein P0 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl10</name>
        <name evidence="2" type="synonym">rplP0</name>
        <name evidence="5" type="ordered locus">TERMP_00195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466470.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00195"/>
    <dbReference type="EnsemblBacteria" id="ADT83172">
        <property type="protein sequence ID" value="ADT83172"/>
        <property type="gene ID" value="TERMP_00195"/>
    </dbReference>
    <dbReference type="GeneID" id="26135525"/>
    <dbReference type="KEGG" id="tba:TERMP_00195"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.196"/>
    <dbReference type="eggNOG" id="arCOG04288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053173_0_0_2"/>
    <dbReference type="OMA" id="MAHVAEW"/>
    <dbReference type="OrthoDB" id="73593at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00280">
        <property type="entry name" value="Ribosomal_L10_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022909">
        <property type="entry name" value="50S_L10_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="RL10_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="RL10P_insert"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RL10P_insert" evidence="4">
        <location>
            <begin position="111"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="339" mass="36874" checksum="ED5DB9908B345E9E" modified="2011-05-03" version="1">MAHVAEWKKKEVERLAEIIKSHPVVALVDVAGVPAYPLSKMREKLRGKALLRVSRNTLIELAIKKAAKELGKPELEKLVDYIQGGAAILATEMNPFKLYKLLEESKTPAPAKPGVPVPRDVVVPAGPTPLSPGPVVGEMQALGIPARIERGKVTIQKDTVVLKAGEIITPQLANILNKLGIEPLEVGLNLLAAYEDGIIYTPEVLAIDEEEYINMLQQAYMHAFNLSVNIAYPTAQTIEAIIQKAFLNAKSVAVEAGYITKETAGDIFGKAFRVALLIAQQLPEELLDEKTKELLNQQAQLAVAAQPQPEEEKVEEVEEEEEEEASEEEALAGLGALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI43</accession>
    <name>F0LI43_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466495.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00220"/>
    <dbReference type="EnsemblBacteria" id="ADT83197">
        <property type="protein sequence ID" value="ADT83197"/>
        <property type="gene ID" value="TERMP_00220"/>
    </dbReference>
    <dbReference type="GeneID" id="10040538"/>
    <dbReference type="KEGG" id="tba:TERMP_00220"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.220"/>
    <dbReference type="eggNOG" id="arCOG00137">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038661_0_0_2"/>
    <dbReference type="OMA" id="PMVVDMT"/>
    <dbReference type="OrthoDB" id="22281at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="442" mass="49182" checksum="FC40D421F27CA76E" modified="2011-05-03" version="1">MNEKFSYKRIFILGFGFFGISIIWALYNAYVPIFLKDFALSSFIIGIVMVIDNVFAIVMLPYLGALSDKTRTRLGRRMPYILIGAPSAAIFFALIPVARAHKNLALMMGTIILMNFFMAVFRSPVIALMPDITPSRFRSQANGIINFMGGLGALFAYFGGKALYDINYALPFYVGAAMMLIANLLVVIFIKEPEEYRKPSKKKVNLWELLKKTSHESFGELKENLKDVFASQEKSLLFILLAIFLWFIAFNSLETFFTSYAKFELGIKESTGAFLLGLFALGFMVFSIPAGFIGGRIGRKKTITLGLFVIIAVMLIALYLGTQAASGKIEVNFVVKAFAALFLLGGFGWGMVNVNSLPMVVDMTTEEKVGGYTGLYYFFSMAANIFAPPLSGIAIDHFGYQSLLIFATMFFVLALIAVQFVRRGDIVGQKPQDIYELIPDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI49</accession>
    <name>F0LI49_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glpK</name>
        <name evidence="9" type="ordered locus">TERMP_00226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466501.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00226"/>
    <dbReference type="EnsemblBacteria" id="ADT83203">
        <property type="protein sequence ID" value="ADT83203"/>
        <property type="gene ID" value="TERMP_00226"/>
    </dbReference>
    <dbReference type="GeneID" id="10040544"/>
    <dbReference type="KEGG" id="tba:TERMP_00226"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.226"/>
    <dbReference type="eggNOG" id="arCOG00024">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_2"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="25345at2157"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="256"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="402"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="493" mass="55122" checksum="82EE9BD2D2532886" modified="2011-05-03" version="1">MGKFILSLDEGTTSARAIIFDRESSILGVGQYEFPQYYPKPGWVEHNPEEIWDAQLRAIKTALKNAKITPEQIAAIGVTNQRETTIIWDKNGKPVYNAIVWQCRRTAEMIEDIKRNYGEMIREKTGLVPDAYFSASKIKWLLDNVPGLREKAQKGEVMFGTVDTFLIYKLTGKHVTDYSNASRTMLFNIKKLEWDEELLEIFGIPDAILPEVKESSEIYGYTKKELFGVEIPVSGDAGDQQAALFGQACFDEGMVKATYGTGNFILVNTGDKIKYSQNLLTTIAWGLNGNISYALEGSVFITGAAVQWLRDGLKIINSAAETEELASKLASNDGVYFVPAFVGLGAPYWDQFARGLIIGITRGTTREHFARATLEAIAYLTKDVIGEMEKEVPIKELRVDGGATKNNFLMQFQADILGKTVIRPVVQETTALGAAYLAGLAVGYWESLEEIGELWKVEKVFEPKMNEKEREKLYRGWKEAVKRALGWARILGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI52</accession>
    <name>F0LI52_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466504.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00229"/>
    <dbReference type="EnsemblBacteria" id="ADT83206">
        <property type="protein sequence ID" value="ADT83206"/>
        <property type="gene ID" value="TERMP_00229"/>
    </dbReference>
    <dbReference type="GeneID" id="26135559"/>
    <dbReference type="KEGG" id="tba:TERMP_00229"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.229"/>
    <dbReference type="eggNOG" id="arCOG05739">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148086_0_0_2"/>
    <dbReference type="OMA" id="PRGKEWA"/>
    <dbReference type="OrthoDB" id="108928at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036593">
        <property type="entry name" value="CPE0013-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012460">
        <property type="entry name" value="DUF1667"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39450">
        <property type="entry name" value="PTHR39450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07892">
        <property type="entry name" value="DUF1667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160148">
        <property type="entry name" value="SSF160148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="121" mass="13548" checksum="A219B748720CCC6D" modified="2011-05-03" version="1">MTVYKFTCIICPLSCDIEVKVENGEIKEIKGYTCPRGKEWAIEEIKNPKRVVMSVIKVKNGNMPTVSVKTTKPIPKTKIPELMKLLAEIEVEAPIKVGQIILENPLGLDTKIVATREVERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI81</accession>
    <name>F0LI81_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-glucuronyl C5-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467709.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01436"/>
    <dbReference type="EnsemblBacteria" id="ADT84411">
        <property type="protein sequence ID" value="ADT84411"/>
        <property type="gene ID" value="TERMP_01436"/>
    </dbReference>
    <dbReference type="GeneID" id="10041752"/>
    <dbReference type="KEGG" id="tba:TERMP_01436"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1436"/>
    <dbReference type="eggNOG" id="arCOG07790">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040765_0_0_2"/>
    <dbReference type="OMA" id="GPWYLEY"/>
    <dbReference type="OrthoDB" id="21365at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047464">
        <property type="term" value="F:heparosan-N-sulfate-glucuronate 5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010598">
        <property type="entry name" value="C5-epim_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039721">
        <property type="entry name" value="C5-epimerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13174">
        <property type="entry name" value="PTHR13174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06662">
        <property type="entry name" value="C5-epim_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C5-epim_C" evidence="1">
        <location>
            <begin position="331"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="511" mass="59779" checksum="94D44CD0AD62B1C0" modified="2011-05-03" version="1">MKQVRIFTFLMIVILSSGCISVETSFHSHNHNYPIKVFVQIEEENAIFEIAKFELTVGNVTIDRLDTPVFVGRVGIDNGKVPIVFTVKGSLINWYGKSFKVKELLSTIFNATSYDEILITLKIYKEDDTFRVGIDEKKSGIIGRDVPEEVFLRPEEALLKRAKGTEFYGELKEEIRENERIRSKLLDEYKRTGNLTYLKSYRDSFYAVRVFGELAKWRRLSEVEYKILLAELKANNAYYSHYTSPTKDFSALVFSDDSPYYSTFRMKDSLNSSLPFIYYTGRGFNLYPVTAIHWAEIYFQRGQNEKALQILKELSWYAQYGEYNGKEYVLFKNYFHFENSSIPWVSGYAQGMGAGVYAIAYNLTGNETYLRIAKGLVNSFDLPPRMNGFVSHTKYGDWYLEYNYNSNELVLNGHIIALQGLYYYWQVTHDEKAWLLFQRGVQAVRNALPIFDTGSWSRYSNIHGDASEFYHRLHIRLLKWLYDVTGDKYFLEYARKWNDYLMIRGLKPEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI98</accession>
    <name>F0LI98_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UbiE/COQ5-like methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467726.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01453"/>
    <dbReference type="EnsemblBacteria" id="ADT84428">
        <property type="protein sequence ID" value="ADT84428"/>
        <property type="gene ID" value="TERMP_01453"/>
    </dbReference>
    <dbReference type="GeneID" id="10041769"/>
    <dbReference type="KEGG" id="tba:TERMP_01453"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1453"/>
    <dbReference type="eggNOG" id="arCOG01791">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_1_2_2"/>
    <dbReference type="OMA" id="CGVGRHS"/>
    <dbReference type="OrthoDB" id="49237at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="45"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="247" mass="28076" checksum="638862DCE3F092E7" modified="2011-05-03" version="1">MKKHEWEDFFDREARHYLKEPFTKHTKEEVEFLLNEFQLPKGAKILDVGCGVGRHSIELAKRGYRVTGIDISQGMLEEARKRAQKEGVEVEFIKADATKFKCEEEFDAAICLCEGAFSLIGSSDDPIEHDLAILKNIYESLKPGGKFILTALSALSRIKGASNEDITKGTFDPNTMTFFEEIEAPDGTKIPIRERVYVPTELYLMFKMVGFEVKAIWGGTAGRWGKRKVDFDDIEIMVIAEKPKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIA0</accession>
    <name>F0LIA0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclomaltodextrin glucanotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467728.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01455"/>
    <dbReference type="EnsemblBacteria" id="ADT84430">
        <property type="protein sequence ID" value="ADT84430"/>
        <property type="gene ID" value="TERMP_01455"/>
    </dbReference>
    <dbReference type="GeneID" id="10041771"/>
    <dbReference type="KEGG" id="tba:TERMP_01455"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1455"/>
    <dbReference type="eggNOG" id="arCOG02948">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_7_3_2"/>
    <dbReference type="OMA" id="LDIVCNH"/>
    <dbReference type="OrthoDB" id="5581at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="6">
        <location>
            <begin position="30"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy_C" evidence="5">
        <location>
            <begin position="422"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="710" mass="81036" checksum="C22737480F68F7E7" modified="2011-05-03" version="1">MRKLAVLLTLLLILPTVYAYQIPEKSVIYQIMVDRFYDGNKSNNHPFYDPTHSNYRLYWGGDLEGIIENLDYIKSLGISMVWLSPVNDNINRMASGSAPYHGYWTRDYKRIEEHFGNWRVFNTLVKEAEKRGICIIVDFVPNHSNPATDGEFGSLYDNGTFITNYYSDSKNATLNPYTGSLENIYHHNGNIKVWEGFELKYGNLFGLADFNQLNPWVDEYLKDGASLFVQSGVCGFRIDAVKHMDLGWLTQFYAHLYMQEPLFIFGEYYKLNFEKDDDMFYFYQYSNVSPQLSIPIRNDIVRTFAFGGSLKTLARELEEYYSHFVYPNKAVNFLDNHDLPRYLSEGKNLDRYHMALGLVMTLPGIPVIYYGDESYLVSKEGKGDPYNRPMMKFDNQTEAARIIRTLAELRKENNALAYGDFKTVYVDYNTWVFERKFGSEKVLVAVNKVNSKNLTLSLNWSDGIYRDVLYGVKMQVKAGKAEISAPKNKVLVFSYEGKQEKPLIGSITPYIAQPGQKLILGGAGFGKSGKVFIEGVRAEVLEWSDDMIVFKMPKLDARKAWVDVYVETDGKKSNRVKLRYLGGNEEAFLLVLNASNLTGQLWIKGNISELAEPIPLMRSKTGYYFQVVSLPVNTSFSVDLYSGLPWEKLEPLNVTLYGKSTNKTIILTRIKPIPKHTQTVTESAAQSPSTSICGTGLVLMLSLIVLFKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIC2</accession>
    <name>F0LIC2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Na(+) H(+) antiporter subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467750.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01477"/>
    <dbReference type="EnsemblBacteria" id="ADT84452">
        <property type="protein sequence ID" value="ADT84452"/>
        <property type="gene ID" value="TERMP_01477"/>
    </dbReference>
    <dbReference type="GeneID" id="26136965"/>
    <dbReference type="KEGG" id="tba:TERMP_01477"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1477"/>
    <dbReference type="eggNOG" id="arCOG01537">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_5_2"/>
    <dbReference type="OMA" id="KIPYFAF"/>
    <dbReference type="OrthoDB" id="28394at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="2">
        <location>
            <begin position="138"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="517" mass="56025" checksum="87CBD0C6193280DC" modified="2011-05-03" version="1">MIEHLPALMIAVPLFGAFIAPLFKKKQSIAAVWAIVITAVTVVLSLMLMYQVRLHGIIVYVFGADKPTLVLPSGYKVPIRIMFEIDGIGAFMAISATLMSFVGALYSYSHVKAESGLEKYYALLLLLEVGILGMVLTGDLFNLFVFLEIAGIAGSALVGFRNYRGEASEAGIKYLIVSAVASLMVLFAIGILYGEYGNLNLAYISRQVSLSTLDMIAFGLLFASFAMKCGSVPMHYWVPDAYTEVPAGINPVLLVSTYASLYALFRVSFTLFANVSISLERVGWIMSILGVLTMFIGVTMALVQKDVKRLMSYHAISQTGYMLLGVGVGLTVLHNSDALAEFGRTAMAGGIFHIINHIIYKSLLLMTAGALFYVTGTRNLNEMGGLARKMPITTLCFIVGAAAISGLPPFNGFASKFLIYESSYRLNPLLAVFAMVTSILTLASFVKVFASAFLGPPLEKFENVREVPRPMIVAMVILALLCILFGLFPDVVLNKIVYPAVDALINVAQYQSWGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LID2</accession>
    <name>F0LID2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane bound hydrogenase NiFe-hydrogenase large subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467760.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01487"/>
    <dbReference type="EnsemblBacteria" id="ADT84462">
        <property type="protein sequence ID" value="ADT84462"/>
        <property type="gene ID" value="TERMP_01487"/>
    </dbReference>
    <dbReference type="GeneID" id="10041803"/>
    <dbReference type="KEGG" id="tba:TERMP_01487"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1487"/>
    <dbReference type="eggNOG" id="arCOG01547">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_2"/>
    <dbReference type="OMA" id="ICSFSHN"/>
    <dbReference type="OrthoDB" id="4328at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00507">
        <property type="entry name" value="NI_HGENASE_L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="2">
        <location>
            <begin position="123"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="428" mass="48591" checksum="1ECB0D61A3F70CEA" modified="2011-05-03" version="1">MNEKIEYWVKIPIGPIHPALEEPEKFIITLDGERIINVDVKLGYNLRGLEWIAMRRNWIQVLYLAERICGICSFSHNHTYARAVEEMAGIEVPERAEYIRVIIGELERIHSHLLNLGVVAHTIGYDTVLHLSWLARERVMDILEDIGGNRVNYAGNMIGGVRRDIKDRHKRAILEMIQYYRQEVMPKVEEIFLYDPTVEARLRDSGVIPKRVAIEYSAQGPTARGSGIRKDVRYNEKLGVYPDLGVKPVTPKEFTGVVKGDVFDRMVVRVGEIWNSMEIIERALDQMPEGKIKAFPKDNLILVKLKKAEGEGIGRYEAPRGELIHYVRAEKGKDGPAKWKMREPTFPNLFAVARALVGEQLADVPVAIASIDPCLSCTDRVAVIDANTGKRKILTEVDLLKESIKKTKEINPNIKARPERIGIGRCML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIF4</accession>
    <name>F0LIF4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc transporter ZIP protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01509</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467782.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01509"/>
    <dbReference type="EnsemblBacteria" id="ADT84484">
        <property type="protein sequence ID" value="ADT84484"/>
        <property type="gene ID" value="TERMP_01509"/>
    </dbReference>
    <dbReference type="GeneID" id="10041825"/>
    <dbReference type="KEGG" id="tba:TERMP_01509"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1509"/>
    <dbReference type="eggNOG" id="arCOG00576">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015114_1_2_2"/>
    <dbReference type="OMA" id="MIFVVIE"/>
    <dbReference type="OrthoDB" id="62488at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="269" mass="29042" checksum="04F522376875560F" modified="2011-05-03" version="1">MLENFIQNIAGYILSASNGNIITIAFYAGLFVALMTSLGSLVAIFAKSLPEWSVEFSLSFAAGVMIVASFTSLILPAIESTNSFSPAGIGVFLGVVLIFGIDKLLPHEHIIKGYEGPKELKDKLKVVWLIIFAMVIHNLPEGLAVGTSIVYNLETGLVTALAIGIQDFPEGIVVALPLAVLQKRRLQPILIGVLSGVAEMIMAVLGALLFVKLNWLLPYGLGLAGGAMLYITVKEMIPEIYKKEENETLITIGFFLGFYVMLFLDSMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIH7</accession>
    <name>F0LIH7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00274"/>
    <dbReference type="EnsemblBacteria" id="ADT83251">
        <property type="protein sequence ID" value="ADT83251"/>
        <property type="gene ID" value="TERMP_00274"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00274"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.274"/>
    <dbReference type="eggNOG" id="arCOG03287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019216_1_0_2"/>
    <dbReference type="OMA" id="EIPHTPY"/>
    <dbReference type="OrthoDB" id="2738at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="2">
        <location>
            <begin position="9"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="GDE_C" evidence="1">
        <location>
            <begin position="230"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="647" mass="74465" checksum="BB87199847724CF1" modified="2011-05-03" version="1">MPKMTLALNGAFVLSDEKGDMNKHYHGFYAFDTRFVKNISLEIDKEMFLRHIEHDNLTAISHILIGGSVILLRKRELLNGWRYREELTFYNMSKEPAKIIPKYFFEVCFEDIFEVRGSHKPIKRKIIKKQTPKGIKYTYIGVDKIKRELEIKAEGFRFENNYLTSEIPLRPLEKKSISIEFSPKIHIKSAPFLIRSVFNFKFEQRVITNNIDVNNIFKTSLRDLASLTILTNHGLTVFAGIPYFMCLFGRDSIITSLFLLPYFPEYAKGTLKILSKLQGRKFDKKTLEESGKIPHEYRLGELSQAHLMPFAPYYGTVDSTPLYLILAGEYVRWTRDYNTVKELKDTLNKALEWIFMKLEEGDGYVRYSLASPYVQMNQGWKDSKEGVPDEHGEPTKPPIALVEVQGYVYKALLDMARLSDILEFEESTLKEEAKKLRRKFNTDFWMKKEKFYAIALNGNNKPSKVISSNPGHLLFTGIAEHEKEIAERLFEKDMFSGWGIRTLSSKERAYNPFSYHNGSVWAHDNALIALGLAKIGETEKAAFLADKFLKAANLMNYQLPELFSGVRSEIPLPIPRANAPQAWSAASPFAFLTAMLGLTPEGVSANPQLPEHLEKIEIKKVIIGGIKYRITIEKKDEQIRFEMNKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LII2</accession>
    <name>F0LII2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MalF-like maltose/maltodextrin ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466554.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00279"/>
    <dbReference type="EnsemblBacteria" id="ADT83256">
        <property type="protein sequence ID" value="ADT83256"/>
        <property type="gene ID" value="TERMP_00279"/>
    </dbReference>
    <dbReference type="GeneID" id="26135622"/>
    <dbReference type="KEGG" id="tba:TERMP_00279"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.279"/>
    <dbReference type="eggNOG" id="arCOG00157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_2"/>
    <dbReference type="OMA" id="NPDYGSI"/>
    <dbReference type="OrthoDB" id="42250at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="89"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="313" mass="35257" checksum="E200629084A9E2B4" modified="2011-05-03" version="1">MFSKFSSFYEKGRNKEIVAGLSLISVAVVLNLVFGYFAMIFAFYLSFFKWDYIGQMQFVGLKNFEIVIRDLIRGFHGAPYLLSPFYTGLKNILIYTAIVVPIQTFLAVVLAAFANQKIRGQQFFKVSYFLPATTSSVIVALIFIWLFMKNGFINYALAHIIPGFQPIDWINDRNYLLLAIAMVAIWGTSGHFMVSFLAAMQAIPREIYEAAMLDGAGPIRRFFFITIPMLRPMIVYVVVMGLIGALQMFDLAWVMAGANGGPGGAGYTVALDIYNEAFTRIRPGVAAAKSWFLFAIIFTTTYLFQKKYGRAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LII3</accession>
    <name>F0LII3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MalG-like maltose/maltodextrin ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466555.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00280"/>
    <dbReference type="EnsemblBacteria" id="ADT83257">
        <property type="protein sequence ID" value="ADT83257"/>
        <property type="gene ID" value="TERMP_00280"/>
    </dbReference>
    <dbReference type="GeneID" id="26135623"/>
    <dbReference type="KEGG" id="tba:TERMP_00280"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.280"/>
    <dbReference type="eggNOG" id="arCOG00159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_2"/>
    <dbReference type="OMA" id="FNSMAAY"/>
    <dbReference type="OrthoDB" id="57718at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="77"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="282" mass="31850" checksum="8788A24CE7C63ACF" modified="2011-05-03" version="1">MTPKEREKLIRRIWIVITYVVLITFALVYLMPFIRSLVASFMTWAQASRYPPEWIPHPFTLENYEKLFRLELFPRWIRNTALYAGLIVAGNILFASMAGYAFARLKFPGRDAIFSALLSLLMIPMFVTLVPNYIIIYKLGLIDNIFGLSLLGLTNVSSIFLMRQYFMSLSNEIFEAARLDGCGPIKAFFYIALPLARPALGAVAVYQFLGSWNAFIGPLIFLRSPENFTLPVGLSFAFQRSMWTEYTPIIAGSLVASAPTIILFLVLNKYLIRGIVITGGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIM7</accession>
    <name>F0LIM7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hydro_114 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466599.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00324"/>
    <dbReference type="EnsemblBacteria" id="ADT83301">
        <property type="protein sequence ID" value="ADT83301"/>
        <property type="gene ID" value="TERMP_00324"/>
    </dbReference>
    <dbReference type="GeneID" id="10040642"/>
    <dbReference type="KEGG" id="tba:TERMP_00324"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.324"/>
    <dbReference type="eggNOG" id="arCOG07957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067038_1_0_2"/>
    <dbReference type="OMA" id="WPDERWI"/>
    <dbReference type="OrthoDB" id="62350at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_114" evidence="1">
        <location>
            <begin position="52"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="313" mass="35996" checksum="02233BC4929E971E" modified="2011-05-03" version="1">MKRYLTFMTFAFISLQTLVYASFAVYYGDVSPTNIDELSKFNLLILSPLVEENYIKELKSKNIIVVGYLSLATIGGWEPWAGEVPDSVIIGHWETWNERETDFSSPQWRDIVLNKAVPYILSKGFDGVFLDNLDYVDKYPEKREAMVELIKAIREKYPDIVIVANRGFSIAEEITPYVDYILFEDFITYYDFNGNKYKIYQDADLQWVLAQAEMLKKLKAKVLALSYADLDNEKQVEEFSKIVCKYAGEYGFEVYMADITLQRIGLNPCENFTKSQVPSSEAKIGEENKNICGSGAILLVIFLPRSLRELILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIM8</accession>
    <name>F0LIM8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding and nucleic acid-binding protein YchF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466600.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00325"/>
    <dbReference type="EnsemblBacteria" id="ADT83302">
        <property type="protein sequence ID" value="ADT83302"/>
        <property type="gene ID" value="TERMP_00325"/>
    </dbReference>
    <dbReference type="GeneID" id="10040643"/>
    <dbReference type="KEGG" id="tba:TERMP_00325"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.325"/>
    <dbReference type="eggNOG" id="arCOG00357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037276_1_0_2"/>
    <dbReference type="OMA" id="QIDCACA"/>
    <dbReference type="OrthoDB" id="51913at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="MMR_HSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="MMR_HSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="397" mass="44444" checksum="83F791AFBC2DC256" modified="2011-05-03" version="1">MEIGVVGKPNVGKSTFFSAATLVDVQIANYPFTTIEANVGVSYVIAEHPCKELGCAPNPQNYEYRDGLALIPIKMIDVAGLVPGAHEGRGLGNKFLDDLRMASALIHIVDASGKTDAEGQPTDYHDPVKDIEFLEKEINYWIYGILKKNWEKFAKRVKLQHLNLARAIADQLTGIGVSEEDILEALHKTNLSNDPTKWSDEDLYNFVSELRRINKPIIIAANKADMASDEQIKRLIEEGKKRNYIVVPTSAAAELTLRKAAKAGYIDYLPGQSDFKILKPLSPKQQRALELIKEKVLDRFGSTGVQEVINKAVFELLQLIPVYPVEDEHKLTDSFGNVLPHVFLMKKGSTPRDLAFKVHTDLGRTFLYAVNARTRRRVGEDYELQFNDIIKIVATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIP1</accession>
    <name>F0LIP1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467791.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01518"/>
    <dbReference type="EnsemblBacteria" id="ADT84493">
        <property type="protein sequence ID" value="ADT84493"/>
        <property type="gene ID" value="TERMP_01518"/>
    </dbReference>
    <dbReference type="GeneID" id="26137029"/>
    <dbReference type="KEGG" id="tba:TERMP_01518"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1518"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_1_1_2"/>
    <dbReference type="OMA" id="TCPVVHF"/>
    <dbReference type="OrthoDB" id="125556at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="80" mass="8805" checksum="4072CE9D29B4AB20" modified="2011-05-03" version="1">MVRAYVLLTVEIGKVEKVIEELKRIPGVTKADAVTGPYDAIIHIEAADLGELTRKILHDIHNIDGVIDTTTAIVVELEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIQ8</accession>
    <name>F0LIQ8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467808.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01535"/>
    <dbReference type="EnsemblBacteria" id="ADT84510">
        <property type="protein sequence ID" value="ADT84510"/>
        <property type="gene ID" value="TERMP_01535"/>
    </dbReference>
    <dbReference type="GeneID" id="10041851"/>
    <dbReference type="KEGG" id="tba:TERMP_01535"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1535"/>
    <dbReference type="eggNOG" id="arCOG00472">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_686286_0_0_2"/>
    <dbReference type="OMA" id="LHYEFKL"/>
    <dbReference type="OrthoDB" id="20262at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="67"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="402" mass="46640" checksum="B998B5A1A8018091" modified="2011-05-03" version="1">MEKPSTLKVYPSPSYEVYGLSRNPFGELASEGIEDIESIHVYQEVDMKLSMIISEVIGNKSSIAFSIVGPLGMGKTQRLKSIAKAISERGGKAIYVKVDTNDILKITRDLFNSMKPPKSRTNIFLENLSRKLGFIDRLEKMLSSTQEYKSRDIAEMLTKELGKYPYSALLLDELENMQSAREQEKIQFFEMLRHFISNMPPGCIVAFACIPEAYEEYTKIFPAFFMRLHYEFKLRPMSLEETFELVKKRLNKVRIRDTDDPIYPFTEEAIKLIHELGKGNPRQILRLLHYVLSEASKHKFDPIDDYVVTTILEEPKNLEEYLTRIPKDYRDLVEAIVYKFNGGPVSYIQVAKEVKKPGIQVYEHLEELIRLGFLIGDPKGNYKVPDYVRRFLEQEKKEEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIR2</accession>
    <name>F0LIR2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxin-like ECF transporter substrate-specific component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467812.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01539"/>
    <dbReference type="EnsemblBacteria" id="ADT84514">
        <property type="protein sequence ID" value="ADT84514"/>
        <property type="gene ID" value="TERMP_01539"/>
    </dbReference>
    <dbReference type="GeneID" id="10041855"/>
    <dbReference type="KEGG" id="tba:TERMP_01539"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1539"/>
    <dbReference type="eggNOG" id="arCOG05752">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084705_1_0_2"/>
    <dbReference type="OMA" id="TIYAPFT"/>
    <dbReference type="OrthoDB" id="91944at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="200" mass="21292" checksum="723AD53624D265E0" modified="2011-05-03" version="1">MEFEVIGTYAKPILALAVLAYFAYIFVIKKEEFKKAQVVAISAVMTALVTVATIVIQVPTPPTRGYINLGDTMVMLSGVLFGPLIGAFAGGFGSALADAITGYAHWAPFTLIIKGLEGLVVGYIAYKREDFTGILIGTIIGGFIMVSGYFLVEVFFYGYPSALVEVPGNTLQAVSGIIVGGGIGYIIKRGYPDIMNLIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIR5</accession>
    <name>F0LIR5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01542"/>
    <dbReference type="EnsemblBacteria" id="ADT84517">
        <property type="protein sequence ID" value="ADT84517"/>
        <property type="gene ID" value="TERMP_01542"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01542"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1542"/>
    <dbReference type="eggNOG" id="arCOG04609">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873242_0_0_2"/>
    <dbReference type="OrthoDB" id="103734at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025645">
        <property type="entry name" value="DUF4349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14257">
        <property type="entry name" value="DUF4349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="312" mass="36025" checksum="27EFD2B2980652D3" modified="2011-05-03" version="1">MHKRNIGIVLLVVVIIVAGFVVSKVFQSGASLKVGNEPEYQPPLYEEKGWDIEAKRVTSTQTMAYAPTYTKPTATQASVGVTNNEKPKEVIQRLKKDYYVIIQDENPEKVTEEIKAEVYSLGGYIISERLTRGQDRTVYYLEFRVPNTAKNENKVGTLLQRYNVKSLRLDTQDVTSKYNQILAEIESLEAEKKKLLEFYNLSKDVDDLLRIEYRISEINSRLNYLYLQKDYYEKVTDYITYHITIESKEKPVFEIDLDFRKTIYQAVAILIMIIRGILALLIIISPFAVLYLVGRRLYKKYGIRASEGVGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIT1</accession>
    <name>F0LIT1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxoisovalerate:ferredoxin oxidoreductase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of one alpha, one beta, one delta and one gamma chain.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467831.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01558"/>
    <dbReference type="EnsemblBacteria" id="ADT84533">
        <property type="protein sequence ID" value="ADT84533"/>
        <property type="gene ID" value="TERMP_01558"/>
    </dbReference>
    <dbReference type="GeneID" id="10041874"/>
    <dbReference type="KEGG" id="tba:TERMP_01558"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1558"/>
    <dbReference type="eggNOG" id="arCOG01608">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002569_5_0_2"/>
    <dbReference type="OMA" id="MKSNYIS"/>
    <dbReference type="OrthoDB" id="29908at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="3">
        <location>
            <begin position="262"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="392" mass="44192" checksum="8F576A6C6EA128EC" modified="2011-05-03" version="1">MPKKVVSGNYAAAYAAKHARVEVVAAYPITPQTSIIEKIAEFIANGEANIQYVPVESEHSAMAACIGASAAGARAFTATSAQGLALMHEMLHWASGARLPIVMVDVNRAMAPPWSVWDDQTDSLAQRDTGWMQFYAENNQEVYDGVLMAFKVAEHKKVNLPVMIIESAFILSHTYDIVDMPPQEEIDEFLPPREPLYTLTDFDNPIAVGALATPADYYEFRYKIEKAMEEARKVIKEVGKEFGERFGRDYSQMIELYRTEDAEFVFMGMGSLMGTVKEAVDLLRKEGYKVGAAKVRWFRPFPKEELYELAKNVDGIAVLDRNFSFGQEGILFNEAKGVLYNTDAHPIMKNYIVGLGGRDFTVNDIRAIAKNMKEIIEKGRLDREIEWYHLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIT4</accession>
    <name>F0LIT4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Low-affinity inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential transporter for phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467834.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01561"/>
    <dbReference type="EnsemblBacteria" id="ADT84536">
        <property type="protein sequence ID" value="ADT84536"/>
        <property type="gene ID" value="TERMP_01561"/>
    </dbReference>
    <dbReference type="GeneID" id="10041877"/>
    <dbReference type="KEGG" id="tba:TERMP_01561"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1561"/>
    <dbReference type="eggNOG" id="arCOG02267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_0_1_2"/>
    <dbReference type="OMA" id="YISMWII"/>
    <dbReference type="OrthoDB" id="40216at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="320" mass="33044" checksum="8DD3AAF62119D1F3" modified="2011-05-03" version="1">MDGIVIAALAVGFYIAWNIGANDSANAMGTAVGAGVLSFRQATFTIAVFVLLGAYLKGYKVMKTVGKGIVPEGYLTIEMAIIALLAAGVWVTIATIKGLPVSTTQAIVGGVVGVGLAIHAPIRWFTLSKIAAAWVVSPIVAGILAMILYKFYGYLINQMRSLGRIELLYKWLAVLGGSYMAFNFGANEVANATGPLVGAGFLEPRVAGIFGALSLALGSLTFSYAVMYTVGKKITALGPASAFAAQFGSAIAVSLANILGLPVSSSQAIVGGVVGVGIITGEGIDKSTIKDIIFGWVATPTTAIIIALIIFHIFRFAGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIV4</accession>
    <name>F0LIV4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrolide export ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467854.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01581"/>
    <dbReference type="EnsemblBacteria" id="ADT84556">
        <property type="protein sequence ID" value="ADT84556"/>
        <property type="gene ID" value="TERMP_01581"/>
    </dbReference>
    <dbReference type="GeneID" id="10041897"/>
    <dbReference type="KEGG" id="tba:TERMP_01581"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1581"/>
    <dbReference type="eggNOG" id="arCOG00922">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="ADRANDW"/>
    <dbReference type="OrthoDB" id="67630at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="231" mass="25828" checksum="F78416C9D07058FF" modified="2011-05-03" version="1">MERRIVLETVDLVKNYYIGRKIVVPALRGVSLKIYEGEFVAIIGPSGSGKTTLLNMLGLLDRPTSGKVYIDGIDVSNLNDNQLSEIRLRKIGFVFQYYNLVPILTALENVELPMLLAGVPRKKRIKRAKELLKSVGLEKFMHHKPNEMSGGQQQRVAIARALANDPSIVLADEPTGNLDTQTSKEIIALMKRINLERGTTFVIVTHDVEVAKEAERILQIRDGKISEVKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIV7</accession>
    <name>F0LIV7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Archaeal ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467857.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84559">
        <property type="protein sequence ID" value="ADT84559"/>
        <property type="gene ID" value="TERMP_01584"/>
    </dbReference>
    <dbReference type="GeneID" id="10041900"/>
    <dbReference type="KEGG" id="tba:TERMP_01584"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1584"/>
    <dbReference type="eggNOG" id="arCOG03166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041137_3_0_2"/>
    <dbReference type="OMA" id="QIANFCY"/>
    <dbReference type="OrthoDB" id="21452at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="304"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="452" mass="53481" checksum="4214165EE973218E" modified="2011-05-03" version="1">MIRKFVNRKEELELLENLWKKEGLVFVLVYGRRRVGKTRLLEEFSKDKERIFVIFEDKPREYNFDLLSKKISELLGVSIKIRDFPSLLRLLKTLKRGRLLLILDELSYLIRREEGILSELSRAIEENRDLNALIVVSGSYVSLMEKEFFRYSSPIYGRTDANIKVAPLKFKHLFEWFEGLKTEDLFKIYAVTNGTPKYLEFFSGENIEEEIIDNFFNPSSFLFREARALLSEELRELSIYLAILEAIAKGNTKVTQIANFCYLKENQVVPYLRVLSELGIVKRIVPIFGKRGVYEIADNYFLFWSRFVNPYYEEIESGFVNAALEDFKANFNQFLGKAFERLAQELLIELSKKNLLPFSFTKIGRWWHRGEEIDLVALNEQERKALFVEVKWKDLTLRETERILNDLRRKAELVGLKDYENYFGIVAKRLDKKDKLDRNILALDLRDFERIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIW0</accession>
    <name>F0LIW0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0310 protein TERMP_01587</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0310 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467860.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01587"/>
    <dbReference type="EnsemblBacteria" id="ADT84562">
        <property type="protein sequence ID" value="ADT84562"/>
        <property type="gene ID" value="TERMP_01587"/>
    </dbReference>
    <dbReference type="GeneID" id="10042564"/>
    <dbReference type="KEGG" id="tba:TERMP_01587"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1587"/>
    <dbReference type="eggNOG" id="arCOG02727">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148445_0_0_2"/>
    <dbReference type="OMA" id="EKNVWGV"/>
    <dbReference type="OrthoDB" id="92589at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00771">
        <property type="entry name" value="UPF0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013989">
        <property type="entry name" value="Dev_and_cell_death_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022996">
        <property type="entry name" value="UPF0310"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51222">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="143" mass="16778" checksum="CAE99F2C6159297E" modified="2011-05-03" version="1">MACWLCITNRDNWEVIKKKNVWGVPKRHKNTIAKVKPGDKLVIYVKQERKDKQILEPKIVGIFEVVSEPYQDSTKIFKSPPHLNETYPLRVKIKPVKLGEVEFKPLIPKLKFITNKKKWSGHLMGKAMRELPEEDYKLIESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIW2</accession>
    <name>F0LIW2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type I site-specific deoxyribonuclease</fullName>
            <ecNumber evidence="3">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">TERMP_01589</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HsdR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467862.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01589"/>
    <dbReference type="REBASE" id="29887">
        <property type="entry name" value="TbaMPORF1595P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84564">
        <property type="protein sequence ID" value="ADT84564"/>
        <property type="gene ID" value="TERMP_01589"/>
    </dbReference>
    <dbReference type="GeneID" id="10041905"/>
    <dbReference type="KEGG" id="tba:TERMP_01589"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1589"/>
    <dbReference type="eggNOG" id="arCOG00878">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005762_0_0_2"/>
    <dbReference type="OMA" id="KCARFHQ"/>
    <dbReference type="OrthoDB" id="2473at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004473">
        <property type="entry name" value="Restrct_endonuc_typeI_HsdR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00348">
        <property type="entry name" value="hsdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="257"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="851"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT84564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="979" mass="116300" checksum="8E5E1D06DBE25D2C" modified="2011-05-03" version="1">MTEWEQCEKPTIERLTSLGWQYKRGTEILEDEKEPLLTSRLKRAIMKINEVSEKEAEEAITFLKTVPFGVEGSRRILEYLKDGVPVKDEETGEPKRLMLIDYKNPENNEFLVANQVGYPFKTKIPDMILYINGIPIVLIECKRLKKDWKEAYRQIKRYEKEMPELFKYVQFSIAIGDRVVYFPNVPWLEDVSVYEWKGESFDDLDNIMEILIPANLLDILKYFIFYREDKGVITKVLPRYMQFRATNKIVERAVKYAKGETERNKGLIWHWQGSGKTLTMIFSAYKIKRLLGNPTIFFIVDRRELEKQLSDELKSIGLSFEVVGSIPKLKEILMHSDGKRGIFVTLIHKFREDELKELREQLKKESRRRKTIMNRKDVIAFIDEGHRTQYGELAATMRSILKNASFFAFTGTPISKKYRDTYATFGYKDEPYLDRYFIIDSIRDGFTVKIAYQARLEDEVRLRKEDLEAFLASKLEEIPEEYREKVEEKLKKKLNAIKIFLKNPKRIEKIAEDIAKHYKESVEPFKAIVVAVDREACVLYKKALDKFLPSEYSEIVMTFNQNDPQIIQEYFNELTRKYRTKDQEEIREEIVTSFKKKEFPKILIVTDMLLTGFDAPILQTMYLDKPLKEHRLLQAIARTNRPFFKNGENIKAFGLIVDYVGIFKELKRALAIYDEVDIKGVAYKLDEIKEELRKKISEALALFDGIELKRDRDTIMKAVLILFQKQKGSEFQRLYREIRYYYKLLREDKTEFKNVFSWLTEVYYAYNSKVNGLDPEIEQKMDAFFKEALKFIHETIDIEKLRTDFPIIELDEEFLKKIMRSTSKEQAFYDLLFAVRHYINTHRGPLTSDLVEQVERIVERWRSKKEEIEKLYEELFTVAQKIQQRTKEREELGLTELEYALVMVLKKHVKTNTAQLISDVKELLNETESLRFPRWKEKADVVSELSRKVMLFIVRKYNRRYGDLFKTRDDILEVLKRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIX0</accession>
    <name>F0LIX0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00339"/>
    <dbReference type="EnsemblBacteria" id="ADT83316">
        <property type="protein sequence ID" value="ADT83316"/>
        <property type="gene ID" value="TERMP_00339"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00339"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.339"/>
    <dbReference type="eggNOG" id="arCOG07571">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2565917_0_0_2"/>
    <dbReference type="OrthoDB" id="104989at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="81" mass="9561" checksum="FB2F0DD42EA2AF47" modified="2011-05-03" version="1">MIYRLKNGNWEKVKLGIFFTLEGYEIMPGESWTQEIRLVYFDESTWNSYPLPPGRYKIIKEALGIGVEGKLTLEVEFEIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIX3</accession>
    <name>F0LIX3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Proliferating cell nuclear antigen homolog</fullName>
            <shortName evidence="3">PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcn</name>
        <name evidence="8" type="ordered locus">TERMP_00342</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466617.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00342"/>
    <dbReference type="EnsemblBacteria" id="ADT83319">
        <property type="protein sequence ID" value="ADT83319"/>
        <property type="gene ID" value="TERMP_00342"/>
    </dbReference>
    <dbReference type="GeneID" id="10040660"/>
    <dbReference type="KEGG" id="tba:TERMP_00342"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.342"/>
    <dbReference type="eggNOG" id="arCOG00488">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_1_0_2"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="OrthoDB" id="70433at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PTHR11352:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PCNA_C" evidence="7">
        <location>
            <begin position="143"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="250" mass="27865" checksum="0D4D016A471A039C" modified="2011-05-03" version="1">MPFEIVFDGAKDFATLIATASNLIDEAAFKVTEDGISMRAMDPSRVVLIDLNLPAGIFSKYEVDGEETIGVNMDHFKKILKRGKSKDILILKKGEENFLEVTLQGTATRTFRLPLIEVEELELELPELPFTAKAVVLGEVLKEAVKDASLVSDSLKFIARENEFIMKAEGETNEVEIKLTLEDEGLLDLEVQEETKSAYGISYLADMVKGIGKADEVIIQFGNDMPLQMDYPVRDEGKLTFLLAPRVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIX5</accession>
    <name>F0LIX5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dehydrogenase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00344</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00344"/>
    <dbReference type="EnsemblBacteria" id="ADT83321">
        <property type="protein sequence ID" value="ADT83321"/>
        <property type="gene ID" value="TERMP_00344"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00344"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.344"/>
    <dbReference type="eggNOG" id="arCOG01491">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_13_3_2"/>
    <dbReference type="OMA" id="CPLDCPD"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00932">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="630" mass="72750" checksum="11F3DEA67E52E6D8" modified="2011-05-03" version="1">MRDCYDTCSIISEIRRGKLFVRGNPKHPITQGFLCPKGALLPKWFYGEERLRVPLIREGKRGAGKFREATWSEAISLVADKIKETIEKYGSESILVYNYAGDRGIVNFYFPMRLFHYLNASFLDYGICDRAGQEALKDVYGTAVGLDPEELKNQKLIVYWGINAFWTNLHGFMLAKKYGLEIWAVDVLKTETAKRSNKFFQIKPNTDVLFALGIARIIIENELYDVDFIRKNVYGFDEFKNYVKKIDLDFVSRETGVEKEQIEEFAFEYAEKRGVIHIGYGFQRSLAGGEAVRTISLLPALVGHEFGFIYDMKTIDKSYAEGAFLRTKPVKRIPQMKLAEYIEMGEIKFLYVYNSNPLASLPNQNRLRKALKESDIFVVVHDIFLTDTALFADVVLPANTFFERLDIADSYYHRYVALNEPVTRLYGKSNREVTVMLAKALGIDNPYLYETEEAIIRKILQQNDLSWEELRKKGFLKVPEKPRKYYTPSGKIEFYSQRAVKRGLSPFPQYTPLKRDYPLQLLSPTYRMTITSQYHNTYGIIDPYLYMNPKDAEERGIKNGDLVEVYNEYGRIKTAVKLTEDVPKGVVVLYKAFWISKLGWNVNVLTADSTVEKYGNASAYHSTWVDVRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ17</accession>
    <name>F0LJ17_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyruvate-formate lyase-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_00386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466661.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00386"/>
    <dbReference type="EnsemblBacteria" id="ADT83363">
        <property type="protein sequence ID" value="ADT83363"/>
        <property type="gene ID" value="TERMP_00386"/>
    </dbReference>
    <dbReference type="GeneID" id="10040704"/>
    <dbReference type="KEGG" id="tba:TERMP_00386"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.386"/>
    <dbReference type="eggNOG" id="arCOG00946">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044176_1_0_2"/>
    <dbReference type="OMA" id="YHFYPGS"/>
    <dbReference type="OrthoDB" id="39920at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="67"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="348" mass="40251" checksum="0854E9B45868C5CB" modified="2011-05-03" version="1">MREAMYWEPLESNRVRCHLCPLNCIIDEGKRGSCRVRENIGGRLYTLNYGMISSMAADPVEKKPLFHFYPGSCAFSIGTVGCNMHCKHCQNWEISQADERFPYLQNATPEGIVSLAKHYECESIAYTYNEPTIWYEFVLDTAKIAKKAGLNNILVTNGYINEEPFRELAPYIDAMNIDIKAFDDKFYMKIASVPTGEPSRRIAKIAKKEFGIHVELTYLIIPTLNDKEDEIRAFARWVVEEIGDDTPVHFSRFFPHYKLLNLPPTPIKTIEMAYRVAKEEGLKFVYVGNIPGHFGEHTYCPKCGKPLIVRWGFTIEEYHIKDGKCEYCGEPIPIIGEYKKRHYRGMWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ50</accession>
    <name>F0LJ50_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467870.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01597"/>
    <dbReference type="EnsemblBacteria" id="ADT84572">
        <property type="protein sequence ID" value="ADT84572"/>
        <property type="gene ID" value="TERMP_01597"/>
    </dbReference>
    <dbReference type="GeneID" id="10041913"/>
    <dbReference type="KEGG" id="tba:TERMP_01597"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1597"/>
    <dbReference type="eggNOG" id="arCOG01004">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_537126_0_0_2"/>
    <dbReference type="OMA" id="MPDSHNA"/>
    <dbReference type="OrthoDB" id="17853at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="433" mass="46349" checksum="9759C2E03A1D08E6" modified="2011-05-03" version="1">MVVEDEVFNDLQTNGIIGPHSKMLGPVADGGRIVFLTAPGCWGPMITPTIKGGHEVNIPVAVEGAKVGDGIVIKIKSVRVLSKAASSGVDTTRKGSFVGDPYVAKKCPSCNEPWPEFEVEGIGEDAVRCKHCGSPASPFKMVNGYTMVFDHGLGIGVTVDKKTAEEIAKNAWEWHALPKNSKQVPILIFAKADIVGVPSRIRPFLGQLGTVPAVDIPDSHNAGDFGYFLIDAPHPYAITKEDYETKLTDGHLDVDAVREGTIVIAPVKVDGGGVYAGDAHAMQGDGEVAGHTTDVTAESVVEVSVVKNMNLDGPILLPPEEDLPPLAKPWRKDEWDNVQKLAKRFGIEVEPVAPVQIIGSGPNINDAAMDGFKRAAKLFGMSVEEIRNRVTISGAVEIGRLPGIVQVSMQVPLRLLEKLGIDELVVKHYGLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ51</accession>
    <name>F0LJ51_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-glucoside-regulated ABC transport system permease component 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467871.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01598"/>
    <dbReference type="EnsemblBacteria" id="ADT84573">
        <property type="protein sequence ID" value="ADT84573"/>
        <property type="gene ID" value="TERMP_01598"/>
    </dbReference>
    <dbReference type="GeneID" id="10041914"/>
    <dbReference type="KEGG" id="tba:TERMP_01598"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1598"/>
    <dbReference type="eggNOG" id="arCOG00159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_2"/>
    <dbReference type="OMA" id="YIVFQRQ"/>
    <dbReference type="OrthoDB" id="46692at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="274" mass="29891" checksum="205042020F91FB6C" modified="2011-05-03" version="1">MKVKPLRILMYAVLIFLAFGYLLPIWSAVTTSTKTGEQVALTTPIQLVLPPYFGAYKIAFESLKRPIINSLVFTTFATIFSTVLGSLAGFTLAKLLRGSVSKKLLILITFGVFLPYQSILIPLVRLISRLGLYNTIPGLVLTHTAYGIPITTLLFTNYYYEIPDELVEAAKVDGASAAGIYTKIILPLSMPAFVVTAIYQFTSIWNDYLFGVVLTRGEEAMPATVMLANLKGSFVANWNVQMAGALIVALPTLIIMIALGKYLIRGYTSGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ85</accession>
    <name>F0LJ85_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467905.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01632"/>
    <dbReference type="EnsemblBacteria" id="ADT84607">
        <property type="protein sequence ID" value="ADT84607"/>
        <property type="gene ID" value="TERMP_01632"/>
    </dbReference>
    <dbReference type="GeneID" id="10041948"/>
    <dbReference type="KEGG" id="tba:TERMP_01632"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1632"/>
    <dbReference type="eggNOG" id="arCOG00429">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018957_0_0_2"/>
    <dbReference type="OMA" id="IGYGPDF"/>
    <dbReference type="OrthoDB" id="1910at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="133"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="742" mass="83412" checksum="350EDDEB4F3796F5" modified="2011-05-03" version="1">MAVKDCPECHGTGKVKVGEKECEVCNGWGYVPADFKLDEHLKGYKNLDYFGVDEEVDEIPCPECHGKGIVPVYDACPTCGGTGRVLACDICGKVKEPWEPGMETTWVCPECERKFKIVYILDKTCDYEDVEIGRIYKGVIDRVERFGVFVKLNPHVVGLIKRKDLLGGKEYKPGMEILVQVLDVRPEKREIDFIESALRQYKEVIVRKELPVTPIEQLSEELAGKTVRIRGKIIQVQVTGGPTVFTITDGTGITWAAAFEAPGVRAYPNINVGDIVEIIGKVSFHAGEIQIEISDMSRLWGPEAAEVKKRIEEELDKKAQPEDVGFLVESEVLEKLKPKIMKAAFMIRRAIYEGRPILLRHHADTDGYVSGLALESAIVPLLKEVSPDPEAEWHLFKRRPSRAPFYELEDVLKDIIFAVEDSMKFGEPLPLVVIVDNGGTTEDIPAYRRLKAYGVPIVVIDHHDPRDFISEDKAAVDEWVDVHVNPHLVKRGYYELTAGMLATELARFINPKVEDKIKHLPAIAGTGDRSKAPEFEQYLKIAKETKGLEEEDLKKIAEVIDHEAYYWKFMDGKGIIEEILLLTGNLQRHRKLIDAIYPEVKAKQEKVLKASLPHVKSIVLPNGIRFNTIDIELYAPKFEYPSPGKLSGLIHDHFKEKYGEDSPILTLAYGPDFAVIRASDGMAAYNFDLNEIIKVLQQKIPDAGVEGGGHSYAGSIKFFEGKRKEVLEEFAKQVVKLKKNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJB3</accession>
    <name>F0LJB3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_01660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467933.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01660"/>
    <dbReference type="EnsemblBacteria" id="ADT84635">
        <property type="protein sequence ID" value="ADT84635"/>
        <property type="gene ID" value="TERMP_01660"/>
    </dbReference>
    <dbReference type="GeneID" id="10041976"/>
    <dbReference type="KEGG" id="tba:TERMP_01660"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1659"/>
    <dbReference type="eggNOG" id="arCOG00767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_2"/>
    <dbReference type="OMA" id="VDCGNGM"/>
    <dbReference type="OrthoDB" id="58941at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03087">
        <property type="entry name" value="PGM_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="149"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="250"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="375"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT84635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="452" mass="50307" checksum="9341438A63E7E13D" modified="2011-05-03" version="1">MKLFGTAGIRGPIDSKVTPELALSVGKALGTYINSGKVVIGRDARTSSVMLENALISGLLSTGCDVIELGLIPTPMLAWATNKLGDAGVMITASHNPPTDNGIKVFNENGVEFYLEQEEELERIIFSQSYKIAKWDEIGKVKKLDLKERYINAVLKFVEHETNLTVLYDGANGTGSMIAPYLLREMGARVISINAHLDGHFPGRKPEPRYENIAYLGDLVRQLGVDLAIAQDGDADRIAVFDEKGNYIPEDTLIALFAKLYVEENKGGVVVTSINTSFRIDKVVRDAGGKVYRVPLGQLHDGIKKYHAIFAAEPWKFIHPKFGMWIDSFVTMGLLIKLIDEEKRPLSEIVKEIPQYPLIKKNVKCPDELKPKVMEVARNELERKLKDEIKEVLTISGVRFNLKDGSWVLVRPSGTEPKIRVVVEGQTEKKMRELFELAYGIVSKAVESLKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJE5</accession>
    <name>F0LJE5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="4">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">ImGP synthase subunit HisF</fullName>
            <shortName evidence="4">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hisF</name>
        <name evidence="6" type="ordered locus">TERMP_00434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the HisA/HisF family.</text>
    </comment>
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        <property type="reaction ID" value="UER00010"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:histidine biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <location>
            <position position="17"/>
        </location>
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        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="257" mass="28349" checksum="2836B03C59468029" modified="2011-05-03" version="1">MSWVIEMLAKRIIAALDIKEGRVVKGIKFQNIRDAGDPIELAKRYEEEGIDEIVFLDITASFEKRRILLDLVKRIAEEIYVPFTVGGGIRSVEEIREIIKSGADKVFLNTAAVENPKLVSEAAKVVGSANLVIAIDAKWNSKYWEVYTHGGRKARGLDAIEWAKEVERLGAGEILLTSMDTDGTQQGFDIPLTKAIVEAVDIPVIASGGAGSPEHFYEAFKIGAEAALAASIFHYGKYTVRELKEYLAKKGVPIRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJF8</accession>
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        <submittedName>
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    </protein>
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            <taxon>Thermococcus</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="ADT83424">
        <property type="protein sequence ID" value="ADT83424"/>
        <property type="gene ID" value="TERMP_00447"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|391623.17.peg.447"/>
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        <property type="component" value="Chromosome"/>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="DUF364" evidence="1">
        <location>
            <begin position="109"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="250" mass="28385" checksum="C58DA090D73DB21E" modified="2011-05-03" version="1">MILRKLKKEALRIIDEDFTIVDFSFALPYTYVVIEGKRGKSLGVAMTLPEEIQMYSNEIEDVDVRKFIEKLDSLNIIERTLAIATINAVSQYYIDLSRTKNEDAVELLDDSIEKVAVIGNMHPIVKTLKERGFDVYVFERNLKLWDRETLSDSLEHWLLPEMDAVIVSGSALVNATLDMILERSKKAKLIVLTGPTAQLLPELLRGSGVTHLASMKVLNIERALTKLKLGTFRGFEKENKKYIIEVPEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJI5</accession>
    <name>F0LJI5_THEBM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
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        <property type="gene ID" value="TERMP_00474"/>
    </dbReference>
    <dbReference type="GeneID" id="10040792"/>
    <dbReference type="KEGG" id="tba:TERMP_00474"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.474"/>
    <dbReference type="eggNOG" id="arCOG10382">
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    </dbReference>
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    <dbReference type="OMA" id="YVESKEQ"/>
    <dbReference type="OrthoDB" id="107893at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="109" mass="12608" checksum="850C0C259A198DCB" modified="2011-05-03" version="1">MSKLAELFENEAIKDFGKALRRALRIGEDYSSLVELEYVESKEQFVEAIKRFLRRYETLAKKGYKGKPLTRPKETSLVELMRLVDEYGVKLVRSALISYTLVKGGEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJJ1</accession>
    <name>F0LJJ1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">TERMP_00480</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83457">
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        <property type="gene ID" value="TERMP_00480"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00480"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.480"/>
    <dbReference type="eggNOG" id="arCOG13133">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3057322_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="53" mass="6175" checksum="E41C7DCB5DFD02F6" modified="2011-05-03" version="1">MLLSILLESYWNTLKEIEEAIRYLMTFNSLGVLLEQGGILPYFPNKSIRTLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJK8</accession>
    <name>F0LJK8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467948.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01675"/>
    <dbReference type="EnsemblBacteria" id="ADT84650">
        <property type="protein sequence ID" value="ADT84650"/>
        <property type="gene ID" value="TERMP_01675"/>
    </dbReference>
    <dbReference type="GeneID" id="10041991"/>
    <dbReference type="KEGG" id="tba:TERMP_01675"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1674"/>
    <dbReference type="eggNOG" id="arCOG05859">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_504929_0_0_2"/>
    <dbReference type="OMA" id="EWEDGRI"/>
    <dbReference type="OrthoDB" id="51935at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="541" mass="61608" checksum="F269FE85CE2429D8" modified="2011-05-03" version="1">MKRVTLIIAITLFLLPLASAQFIVFSSQGEILVLSGDYTEGTFILKNDQNFDFKIVSFRKYVVLDERLNRVEGFRLELQKTIYNEWTSGETREISYKLFVNESVKPGNYQIVLTFWGFLESGDIYIITAKIPVKVIDKPLIFEEAITYVKERPFSSNYVLNGETVVVSSHIKNLKNSIIPLKASTYLERNGKKYLLVTKTVNLTKGDNIVRFEIPIPYDLPSGNYKLVYLLEYPGGTYSFSKEYYIQFGVELSALSLKSTQVMEDFENEAYVTLTSERDIKVNVTLLTYDKNGELLHKYAETVQLQKGTNIVRFSLPSAPPGEVKVLVKVTYDGIFLGERSATYHVMAYPKIDSVTYRILYNGKVEFTVAIMNENSKKIEGVLHYKITAANETLYKGLKDITLFPGENKVRLEFTLPEGEAEYQFVLSAFGKNTIKEGTVYIEKQTPTQTLSSPSSSSTIKTKETTSQLIGGEHKEKKTWVMYLVGILIAAVLTAVLIGLVKSDKKKKRKRPRPKKKSPLGKYKRPKIPKFVEKRELPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJL2</accession>
    <name>F0LJL2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Glutamine synthetase</fullName>
            <ecNumber evidence="5 10">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TERMP_01679</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Oligomer of 12 subunits arranged in the form of two hexagons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="5 10"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467952.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01679"/>
    <dbReference type="EnsemblBacteria" id="ADT84654">
        <property type="protein sequence ID" value="ADT84654"/>
        <property type="gene ID" value="TERMP_01679"/>
    </dbReference>
    <dbReference type="GeneID" id="26137122"/>
    <dbReference type="KEGG" id="tba:TERMP_01679"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1678"/>
    <dbReference type="eggNOG" id="arCOG01909">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_1_3_2"/>
    <dbReference type="OMA" id="PHPHEFE"/>
    <dbReference type="OrthoDB" id="47310at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="11">
        <location>
            <begin position="97"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="7">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT84654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="440" mass="50321" checksum="9A7CC22A011A3DE6" modified="2011-05-03" version="1">MNEIKSMTMMERRKIKFLQLIFVDINGVPKGMEVPIERYEEAISDGISFDGSSIPGFQGIEDSDLIFKADPSTYAEIPWEGVARVYGFIYKDDKPYHADPRGILKSVSDELAKEGLKVYIGPEPEFYLFRKNGTWELQLPDVGGYFDIINLDKAKDVKREIALYMPYFGLTPEVLHHEVGAGQHEIDFRFSDALGTADNIISFKYVVKAVAESHGLYATFMPKPIYGMPGNGMHLHISLWKDEENLFVGEDGLSETALYFIGGILKHAKALAALTNPTVNSYKRLVPGYEAPVYVSWGYRNRSALIRVPAYKGKGARIEYRCPDPSANPYLAFAAIIEAGLDGIKHKIEPFAYVEENVYEMDREKRIETGIETLPSSLKEALDELEKDKIVRKALGKAYRNFKEYKEREWGEYIEYLKKRNIPLETKEVTEWELERYFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJN3</accession>
    <name>F0LJN3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">V-type ATP synthase subunit K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467973.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01700"/>
    <dbReference type="EnsemblBacteria" id="ADT84675">
        <property type="protein sequence ID" value="ADT84675"/>
        <property type="gene ID" value="TERMP_01700"/>
    </dbReference>
    <dbReference type="GeneID" id="26137099"/>
    <dbReference type="KEGG" id="tba:TERMP_01700"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1699"/>
    <dbReference type="eggNOG" id="arCOG02455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126047_0_0_2"/>
    <dbReference type="OMA" id="NFIQLGA"/>
    <dbReference type="OrthoDB" id="111693at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="96"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="161" mass="15828" checksum="24549883FDBAE75F" modified="2011-05-03" version="1">MDPIVYVALGMALAAGIAGAASSFGVGIAGAAAAGAVAEDEKNFKNALILEGLPMTQSIYGLITLFLIALVSGILGGSFKFAATTQENIIKSAILLGAGLTVGLTGLSAIPQGIIASAGIGAVAKNPKTFTQGIIFAAMAETMAIFGLVGALILIVTGVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJW8</accession>
    <name>F0LJW8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolyl endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466803.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00528"/>
    <dbReference type="MEROPS" id="S09.002"/>
    <dbReference type="EnsemblBacteria" id="ADT83505">
        <property type="protein sequence ID" value="ADT83505"/>
        <property type="gene ID" value="TERMP_00528"/>
    </dbReference>
    <dbReference type="GeneID" id="10040846"/>
    <dbReference type="KEGG" id="tba:TERMP_00528"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.528"/>
    <dbReference type="eggNOG" id="arCOG01647">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011290_1_1_2"/>
    <dbReference type="OMA" id="KSGHMGA"/>
    <dbReference type="OrthoDB" id="3853at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="419"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="619" mass="71055" checksum="72A56646FCB4F35D" modified="2011-05-03" version="1">MEDPYLWMENLNDERVLKFIEEENKRFREFIEDLPEKLIDDVRKYYYLPNIWEAQITKRGTFVKINEAGRQLIKLLETGEIIVDSKKLEEELGDEILLQGFTVDRDGKRLAYNFSIGGADEGITRIVNLETGEIIEEIKPSLWNIVFLDDGYYFARFYRKEKTPDGISAPAERIFLKKGEDEVMVSGEGFGSGYFMNLHKSTDGKWAMLTVTFGWNKADIYLGPIDEPEKWRKVYSSDVPAHPIDVINGKLYIYTRKGRGLGKVIAIENGKVEEIIPEDEFPLEWAVIVNDKILAGYLVHASSKLKVFTLEGELIDGISFKMPAQVYPLDNDGEQVLLRYESFTVPYRLYRFRDRLELIDEIKVEGEFEVSEDFATSKDGTRVHYFMVKKKGTKSDKAWVFGYGGFNIALLPRFVPQVIPFIERGGTFVMTNLRGGSEYGEEWHRQGMRENKQNVFDDFIAVLEKLKREGYKVAAWGRSNGGLLVSAVLVQRPDVMDAALIGYPVIDMLRFHKLYIGSVWIPEYGNPDEPKDRKFLLKYSPYHNVKPQKYPPTLIYTGLHDDRVHPAHALKFAKKLKDVGAPVYLRVETKSGHMGASPETRIKELADLLAFVIKVLGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJX8</accession>
    <name>F0LJX8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfhydrogenase II subunit g</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00538</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="4">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00538"/>
    <dbReference type="EnsemblBacteria" id="ADT83515">
        <property type="protein sequence ID" value="ADT83515"/>
        <property type="gene ID" value="TERMP_00538"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00538"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.539"/>
    <dbReference type="eggNOG" id="arCOG02199">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_1_1_2"/>
    <dbReference type="OMA" id="NTARYGK"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="291" mass="32829" checksum="2792BA0E08A2673A" modified="2011-05-03" version="1">MMTTTQIVHGDNPYALEKVKVLKVYKLTDKEKLFLFRFEDPEIAETWTFKPGQFVQLTIPGVGEVPISICSSPMRKGFFELCIRKAGRVTTVVHRLQPGDTVLVRGPYGNGFPVDEWEGMDLLLIAAGLGTAPLRSVFLYAMDNRWKYGNITFINTARYGKDLLFYKELEAMKDLAESENVKIIQSVTRDPEWPGLKGRPQNFIVEANTNPKKTAVAICGPPRMYKAVFESLINYGYRPENIFVTLERRMKCGIGKCGHCNVGTSTSWKYICKDGPVFGYFDIISTPGLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJY6</accession>
    <name>F0LJY6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00546"/>
    <dbReference type="EnsemblBacteria" id="ADT83523">
        <property type="protein sequence ID" value="ADT83523"/>
        <property type="gene ID" value="TERMP_00546"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00546"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.547"/>
    <dbReference type="HOGENOM" id="CLU_1017883_0_0_2"/>
    <dbReference type="OrthoDB" id="134902at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="273" mass="31700" checksum="AACFE00F43AD99CA" modified="2011-05-03" version="1">MIVLATKHKGNRMWERGYLQGFFSANERTAKMWRQLIEYIHPEGEKALEKYEDLERKRVFGASEGAAKPIVKHDLAEATKLSLWLKIFGEAAASILGITPHKLFTIILLEDVDSHLQPWKHHDEDPLGINWYLIIEEALKESRYTEEYLGRKIAEEELKKLEEVAKVIAKFVDAWGPDNINHAQIWLAEGSNMDDLEEFIKKYAKDPEKAFQYLEELRQVMHKCIKPKGLVDRRQKVESSALLEIRRELQSLKEENKKLQKGNGRAKKGNPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJY7</accession>
    <name>F0LJY7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Archaeal ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466822.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00547"/>
    <dbReference type="EnsemblBacteria" id="ADT83524">
        <property type="protein sequence ID" value="ADT83524"/>
        <property type="gene ID" value="TERMP_00547"/>
    </dbReference>
    <dbReference type="GeneID" id="10040865"/>
    <dbReference type="KEGG" id="tba:TERMP_00547"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.548"/>
    <dbReference type="eggNOG" id="arCOG03166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041137_3_0_2"/>
    <dbReference type="OMA" id="GMIRKIF"/>
    <dbReference type="OrthoDB" id="21452at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="321"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="466" mass="55357" checksum="C1CF124200465256" modified="2011-05-03" version="1">MFYNRKAELEKLEKIYAHPGSTFVVIYGRRRVGKTALVREFLKNKLGLYFFVGEKDEAMLIEEYLKEIENVLGEHFPSYFTPRFSSLEELFEFLLDFSKEQKLIVVFDEFQNFRSVKPSFFSSLQKLWDMKNEANLILIAVGSYVGMMKRIFMDNKEPLFGRVDEWIKLRPFDFWTAYDFVNTFANVPPNHFVELYSALGGMPRYLLYLKRYYTGNVAETLNNLFFDEFAPLREEGLNTLKLEFGRFYRSYFSILEAVSLGYATPKEISDKTGLKLLTVGKYLSELTNHYEYLRREVPVTEDPRKTRKVSYRVADEFFNFWFRFVYHNYTYLEEGNLDLVLDDLERNFPAFVGKTYERIAFEFVKRINLGFKPLRVGSWWHKGEEIDVVAYNRENIALFEVKWSDLRKIDVSRILRNLKRKSKLLPLTGSLRLGVIARTIEDKEHFLENGFLVFDLEDLMMKKKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK39</accession>
    <name>F0LK39_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010884736.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="SMR" id="F0LK39"/>
    <dbReference type="STRING" id="391623.TERMP_01776"/>
    <dbReference type="EnsemblBacteria" id="ADT84751">
        <property type="protein sequence ID" value="ADT84751"/>
        <property type="gene ID" value="TERMP_01776"/>
    </dbReference>
    <dbReference type="GeneID" id="33322128"/>
    <dbReference type="KEGG" id="tba:TERMP_01776"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1775"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_2_2_2"/>
    <dbReference type="OMA" id="MIVYGPY"/>
    <dbReference type="OrthoDB" id="125556at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="75" mass="8602" checksum="67F8C97935354FC1" modified="2011-05-03" version="1">MVTAFILMVTAAGKEREVMEKLLAMPEVKEAYVVYGEYDLIVKVETDTLKDLDQFITEKIRKMPEIQMTSTMIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK74</accession>
    <name>F0LK74_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-archaeol synthase</fullName>
            <ecNumber evidence="6">2.7.7.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">carS</name>
        <name evidence="7" type="ordered locus">TERMP_01811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:25690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="ChEBI" id="CHEBI:58838"/>
            <dbReference type="EC" id="2.7.7.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CDP-archaeol synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.67" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468082.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="SMR" id="F0LK74"/>
    <dbReference type="STRING" id="391623.TERMP_01811"/>
    <dbReference type="EnsemblBacteria" id="ADT84786">
        <property type="protein sequence ID" value="ADT84786"/>
        <property type="gene ID" value="TERMP_01811"/>
    </dbReference>
    <dbReference type="GeneID" id="10042127"/>
    <dbReference type="KEGG" id="tba:TERMP_01811"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1810"/>
    <dbReference type="eggNOG" id="arCOG04106">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105710_0_0_2"/>
    <dbReference type="OMA" id="GKTWRGT"/>
    <dbReference type="OrthoDB" id="124973at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043338">
        <property type="term" value="F:CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01117">
        <property type="entry name" value="CDP_archaeol_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032690">
        <property type="entry name" value="CarS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002726">
        <property type="entry name" value="CarS_archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39650">
        <property type="entry name" value="PTHR39650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01864">
        <property type="entry name" value="CarS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="168" mass="18730" checksum="9D26BC70334AA21B" modified="2011-05-03" version="1">MNPLFEALWYILPAYFANASPVIFKGKTPMDFGKEFIDGKRLLGDGKTWRGFFGGLLTGIFISIIQYHITPNFYGSFAVALKLGFALSLGALIGDLIGSFVKRRVGMERGYPAVGLDQWGFLIAALIFAYPIKTLSTGQVLFLLAVTPFIHWFANVFAYKMGWKSVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK83</accession>
    <name>F0LK83_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TrkH-like system potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_01820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468091.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01820"/>
    <dbReference type="EnsemblBacteria" id="ADT84795">
        <property type="protein sequence ID" value="ADT84795"/>
        <property type="gene ID" value="TERMP_01820"/>
    </dbReference>
    <dbReference type="GeneID" id="10042136"/>
    <dbReference type="KEGG" id="tba:TERMP_01820"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1819"/>
    <dbReference type="eggNOG" id="arCOG04145">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030708_0_2_2"/>
    <dbReference type="OMA" id="GSMNHFS"/>
    <dbReference type="OrthoDB" id="13996at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004772">
        <property type="entry name" value="TrkH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006247">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="489" mass="53946" checksum="52EE93DCD6626A95" modified="2011-05-03" version="1">MKLKETLALLGEIMLLFSISFLAPLTVALYYKTPISPFLIPMVMSLIIGGFLRSLGAGEEIGIREAFLLVSLAWLSIAVLGALPYILAGEGSIANPLNALFESMSGFTTTGATVVVDFSIHSKAILFWRQLTQWLGGMGIVVLAIAILPRLSVGGSELMSLEAPGPQLEKLTPHIKNTARIFWGIYVGLTAMETLILITLHYIGIAPKMTPYMALVHSFTTMSTGGFSPLSQSIKAFSPAVQWIITIFMILAGANFALFWYLMRKDYRIIRNEEFRWYIFAILGLSLLTVPYLEHQFNLNFITAFRYSIFQVASIVTTTGYATMNFSRWVFPAQFILFFAMFLGGSSGSTAGSIKIVRWVTALKAIKRELSLSFHPKSLMNVKLGGIVVGERSIRSALAFIALYFIIFSVSSLFVILNGASVNLNPTDAMSAVAATLGNIGPGIGKIGPMANYLIFPPQTRALMIVLMWFGRLEIVTVLVLFTRSYWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKD6</accession>
    <name>F0LKD6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00617"/>
    <dbReference type="EnsemblBacteria" id="ADT83594">
        <property type="protein sequence ID" value="ADT83594"/>
        <property type="gene ID" value="TERMP_00617"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00617"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.619"/>
    <dbReference type="eggNOG" id="arCOG03113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097039_4_2_2"/>
    <dbReference type="OMA" id="FMLQSID"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="127" mass="14189" checksum="5E87613A45EFABD6" modified="2011-05-03" version="1">MLTPNVNYALVFILPAETRANASIHMFFMLQSIDVIFLNSAREVVDFKKAKPWRVYIPREAAKYIIEGPHGIIKALDVAIGDKLSWIVEDEKEKAVPSPSNVINGVSFKKINGTISLAEPKPKLKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKF9</accession>
    <name>F0LKF9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466915.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00640"/>
    <dbReference type="EnsemblBacteria" id="ADT83617">
        <property type="protein sequence ID" value="ADT83617"/>
        <property type="gene ID" value="TERMP_00640"/>
    </dbReference>
    <dbReference type="GeneID" id="10040958"/>
    <dbReference type="KEGG" id="tba:TERMP_00640"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.642"/>
    <dbReference type="eggNOG" id="arCOG01978">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041129_0_0_2"/>
    <dbReference type="OMA" id="DMIDLGM"/>
    <dbReference type="OrthoDB" id="58231at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005236">
        <property type="entry name" value="Dihydropt_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045406">
        <property type="entry name" value="DUF6513"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20123">
        <property type="entry name" value="DUF6513"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00284">
        <property type="entry name" value="TIGR00284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="141"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="506" mass="57489" checksum="058F0D15D9D33AB9" modified="2011-05-03" version="1">MKILLVTGKLAEPLVRKYGKDCDVFVAPVSVAAFLTPKLIAHYLKKAGIKSEDHDLILIPGLVRGSAQIIEDELGIPTFKGPKYAFDLPQVLKALREGFKLSKEVPADDLFQRDALKKVEDIKNKTKNKVYIKRALKKPYNFLIGNLPVGFDFPHRILAEIVDAPELSVDETVDKAVYYLESGADIIDIGMVSGETNLEFIEVIPEVRDALRERGYDVPVSFDSLNTKEIERALDYADLFLSIDESNLEEIVIEKPVVLIPTNQKKGFFPRDPHERVEFLEMLKEKAIDLGYKRIIPDLILEHIPNLARSITAFQLYRERNPDDVLLAGVGNVVELIDADSVGINAVMAGFAKELKISLLLTTEVSPKCRGAVKELRRALDMMLFDMPKDLGFDLLILKEKRSEKVEYEIKSPIIKAKEKEVKLEDIYFRISTKKGKIWVIAHRGSEQILTIVGEEPNAIIDTILEHFQISPRHAFYLGRELERAKTALKLKRSYIQEVELFKEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKG5</accession>
    <name>F0LKG5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466921.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00646"/>
    <dbReference type="EnsemblBacteria" id="ADT83623">
        <property type="protein sequence ID" value="ADT83623"/>
        <property type="gene ID" value="TERMP_00646"/>
    </dbReference>
    <dbReference type="GeneID" id="10040964"/>
    <dbReference type="KEGG" id="tba:TERMP_00646"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.648"/>
    <dbReference type="eggNOG" id="arCOG00016">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065902_3_1_2"/>
    <dbReference type="OMA" id="IINPVAN"/>
    <dbReference type="OrthoDB" id="98664at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019140">
        <property type="term" value="F:inositol 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010264">
        <property type="term" value="P:myo-inositol hexakisphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031094">
        <property type="entry name" value="MIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43085:SF13">
        <property type="entry name" value="PTHR43085:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="282" mass="32412" checksum="4B99BF21EE3ECDEF" modified="2011-05-03" version="1">MKCLIVGHLTHDIILRGNVRIERIGGGVYYSALVLSPFCDVEIITKVGKDFPKEWLRELKERGIWITLLPSKYTTTYELRYLDENTRILRLLSKADSFRVSEIPTDNWDIILLNPVANEISGEIVKKMRGFISIDVQGFVRSFENGKVGLKKTNASFLSNAKIVHADVNEFEMLDEIDNKPEVMLISNGADRGEAVYRGERYHFEPIKMSVAETTGAGDSFLAYFSYFYKQYPFMKALKMTVSFTAFFLKYRTPFFDFDEARENAKNVKVEKIVTDEETSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKR0</accession>
    <name>F0LKR0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ExtraCellular Mutant Ecm15p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466937.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00662"/>
    <dbReference type="EnsemblBacteria" id="ADT83639">
        <property type="protein sequence ID" value="ADT83639"/>
        <property type="gene ID" value="TERMP_00662"/>
    </dbReference>
    <dbReference type="GeneID" id="26136062"/>
    <dbReference type="KEGG" id="tba:TERMP_00662"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.664"/>
    <dbReference type="eggNOG" id="arCOG04373">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137479_3_1_2"/>
    <dbReference type="OMA" id="TPMGTVF"/>
    <dbReference type="OrthoDB" id="126214at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00106">
        <property type="entry name" value="TIGR00106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="93" mass="10284" checksum="68FBAF95FF3C9895" modified="2011-05-03" version="1">MAVAEICLFPLGTDTPSVGNYLEPVIEEIRRSGLKYMVCPMGTVVEGNIDSILRLIKRCHEVIFKAGAKRVVISVKIDDRIDKPITIESKLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKR5</accession>
    <name>F0LKR5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466942.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00667"/>
    <dbReference type="EnsemblBacteria" id="ADT83644">
        <property type="protein sequence ID" value="ADT83644"/>
        <property type="gene ID" value="TERMP_00667"/>
    </dbReference>
    <dbReference type="GeneID" id="26136067"/>
    <dbReference type="KEGG" id="tba:TERMP_00667"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.669"/>
    <dbReference type="eggNOG" id="arCOG05824">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2802469_0_0_2"/>
    <dbReference type="OMA" id="PEEHINY"/>
    <dbReference type="OrthoDB" id="129360at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="68" mass="8172" checksum="8A8B83037D131A52" modified="2011-05-03" version="1">MDKKLDEFIGSPIKVRQEKARKNNKKKRLRMTKLDNFLPEEHINYFKALRIGSKRIRNVKISEISNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKS5</accession>
    <name>F0LKS5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466952.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00677"/>
    <dbReference type="EnsemblBacteria" id="ADT83654">
        <property type="protein sequence ID" value="ADT83654"/>
        <property type="gene ID" value="TERMP_00677"/>
    </dbReference>
    <dbReference type="GeneID" id="26136076"/>
    <dbReference type="KEGG" id="tba:TERMP_00677"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.678"/>
    <dbReference type="eggNOG" id="arCOG03107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083552_1_1_2"/>
    <dbReference type="OMA" id="VTVDHQR"/>
    <dbReference type="OrthoDB" id="88642at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015796">
        <property type="entry name" value="Impact_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00257">
        <property type="entry name" value="IMPACT_YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="141"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="205" mass="22638" checksum="92919A021BCE23F6" modified="2011-05-03" version="1">MSYKTLRGIGTAELVIKKSVFIGYASPANSEEEAKAFIAKIKAHHRDAAHNVSAYLINDGKSFALRYDDDGEPKGSAGKPVLKVIQNKGLSNVVVVVTRYFGGIKLGYGGLVKAYSDAASLAIENAGISEIFETERFETVFPYNLYHTVKETVEKNGGKVVDEEYGERVRFTVEIRKGEAGSLMNLLIEKTRGRIKLRPLFMRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKW6</accession>
    <name>F0LKW6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466993.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00718"/>
    <dbReference type="EnsemblBacteria" id="ADT83695">
        <property type="protein sequence ID" value="ADT83695"/>
        <property type="gene ID" value="TERMP_00718"/>
    </dbReference>
    <dbReference type="GeneID" id="10041036"/>
    <dbReference type="KEGG" id="tba:TERMP_00718"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.720"/>
    <dbReference type="eggNOG" id="arCOG01791">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_1_2_2"/>
    <dbReference type="OMA" id="FFSSIMY"/>
    <dbReference type="OrthoDB" id="49237at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="45"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="250" mass="29243" checksum="1CBED8F8965E87FE" modified="2011-05-03" version="1">MHELYTVLAEYYDVIYRRRAKRVGEEIDFVEEIFKNDAKREVKKVLDLACGTGIPTVELARRGYEVVGLDLHEEMLRVARRKAQELGLNIEFIHGDALDINFENEFDAVTMFFSSIMYFDENAIKQLFNSVIKALKPGGVFVADWSNLCFLQFDRAPTIWEEKNGDETVITTSWKEIENATQRFHLKYLVQILKPNGTIRAFHVHEVLNAYTPREIRLLAEKYFSEVKIYGDMKRNLGKNAYRFWLVGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKY2</accession>
    <name>F0LKY2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5615 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01914"/>
    <dbReference type="EnsemblBacteria" id="ADT84889">
        <property type="protein sequence ID" value="ADT84889"/>
        <property type="gene ID" value="TERMP_01914"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01914"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1913"/>
    <dbReference type="eggNOG" id="arCOG07904">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3021157_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041049">
        <property type="entry name" value="DUF5615"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18480">
        <property type="entry name" value="DUF5615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5615" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="55" mass="6327" checksum="277BBB5555C68003" modified="2011-05-03" version="1">MKFLADENIPLKVVKKLREEGFDIISITELNPGISDEKVAEISQNEDRVLVTFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL13</accession>
    <name>F0LL13_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA(U54)-2-thioribothymidine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468216.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01945"/>
    <dbReference type="EnsemblBacteria" id="ADT84920">
        <property type="protein sequence ID" value="ADT84920"/>
        <property type="gene ID" value="TERMP_01945"/>
    </dbReference>
    <dbReference type="GeneID" id="10042261"/>
    <dbReference type="KEGG" id="tba:TERMP_01945"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1944"/>
    <dbReference type="eggNOG" id="arCOG00042">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_1_1_2"/>
    <dbReference type="OMA" id="CLHINLG"/>
    <dbReference type="OrthoDB" id="57500at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00269">
        <property type="entry name" value="TIGR00269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="307" mass="35582" checksum="621F42E6F1F2B334" modified="2011-05-03" version="1">MKCKFCEKKAFIKLHYPKMYLCREHFIEYFERKVKRTIEKYKLLKRDERILVVVSGGKDSAVVSYVLKKLGYNIECLYINLGIGEYSAKSEEYAKKQCEMINAKLHIVRVRELLGAGIGELKTSRPTCSYCGITKRYIFNKFAYDNGFDVIVTGHNLDDEASFIFGNIMNWNTQYLAKQGPLLPGEGKFVKKVKPLYEVTEREVVAYALAVGIDYMVEECPHARGATTLSYKEILNDMEEKRPGTKINFVKGYLRKRHLFEQEIEEVEFKECKVCGMPALGEKCSFCKVWRLEKPIDFRIKPQISST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL57</accession>
    <name>F0LL57_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00731</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467006.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00731"/>
    <dbReference type="EnsemblBacteria" id="ADT83708">
        <property type="protein sequence ID" value="ADT83708"/>
        <property type="gene ID" value="TERMP_00731"/>
    </dbReference>
    <dbReference type="GeneID" id="26136139"/>
    <dbReference type="KEGG" id="tba:TERMP_00731"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.733"/>
    <dbReference type="eggNOG" id="arCOG00751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_843637_0_0_2"/>
    <dbReference type="OMA" id="FVEMFTD"/>
    <dbReference type="OrthoDB" id="49905at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="120"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="351" mass="39820" checksum="BA58DDB34DA72B14" modified="2011-05-03" version="1">MRIAKRALGKIVAIYITVMLILVLTAGVTANHLLKERAKDLAAYGIGMKNPVLYEQIKREAAEEGVEPWEYIYEHLLLEKYGLSKNPFIMGIQLLLNKGEPLKTQIDKRKERELSLSRATLVTLTVMLSSVALIVAFGVIFGMKLANHPRLLEIIEGITRLFNGLPSWWIGVLLIVIFAVKLNVLPTGGLFTPKPLYGVAYVVDLVKHLILPIMTLFLVFIWEFMSIVARETQKEMYQPYIQTERAKGIPEKLIYRKHILRNIGIVLSSFTAQKFMEMFTDYLVIDYLFGLMGLGLVLKNSFVREIIPNVGVQITFNFYLFFATTLIIATISFGVSLFLEFLKGVIDPRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL59</accession>
    <name>F0LL59_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467008.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00733"/>
    <dbReference type="EnsemblBacteria" id="ADT83710">
        <property type="protein sequence ID" value="ADT83710"/>
        <property type="gene ID" value="TERMP_00733"/>
    </dbReference>
    <dbReference type="GeneID" id="10041051"/>
    <dbReference type="KEGG" id="tba:TERMP_00733"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.735"/>
    <dbReference type="eggNOG" id="arCOG10087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1674074_0_0_2"/>
    <dbReference type="OMA" id="DAPYGFY"/>
    <dbReference type="OrthoDB" id="112119at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="157" mass="17766" checksum="FC792A327B0F9D1A" modified="2011-05-03" version="1">MKREQLKFLLINLLALAVLQPGAVAFANFDAPYGFLKDLSAWLEAYIGVMPLIVIYAVWDREKLGKKVIGGYLIFTALLMSLSYYLSKLVVADINPSFSFKDFLILCPVSTLLALMLFIPSLVHIHRLYYSYDLPLVIAELLVVLAVFLVYTKLRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL62</accession>
    <name>F0LL62_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467011.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00736"/>
    <dbReference type="EnsemblBacteria" id="ADT83713">
        <property type="protein sequence ID" value="ADT83713"/>
        <property type="gene ID" value="TERMP_00736"/>
    </dbReference>
    <dbReference type="GeneID" id="10041054"/>
    <dbReference type="KEGG" id="tba:TERMP_00736"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.738"/>
    <dbReference type="eggNOG" id="arCOG05807">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07974">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_627933_0_0_2"/>
    <dbReference type="OMA" id="MLHDINE"/>
    <dbReference type="OrthoDB" id="72283at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="436" mass="49910" checksum="5866F36BF2E20811" modified="2011-05-03" version="1">MKMSMKTLLVLFIGALIPLSTAWAATNTTAVSNVLVVNATNVTNTTPVNMTNVTNTTTKNTSAVQAYNLLLILDKVANYTAGLMAELNASNVTISNYTLDLYSQAETARAQAWELYNTGNYSESINASMNALYLYKEAIEELTDYYEEHKEKKMEEQYEYYELIMDAKEELQRAREYFPYVEKVIAEAKAEGLNVTYVMELYNETKAAYMVVAQDLASGNVTALKADLEYAEELMDKLEDAVEELQEQIVSAKADEISQAFMEKLQEQMKLMNELLAMLQNSTINATYLQENLMELQTMYEQFNALVESGQYEEALDMLHDINEELKEIIEDTKEIEREYKEEIEEKGEHKDEKDSEDEYEDDHKKTDEHKDEYTSDESEDDQNGNYEEQSDNDDGNTGNYEEQESHDEDNGQHEDSEDNNGDGEHNGEDESEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLC4</accession>
    <name>F0LLC4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP-binding Era-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467073.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00798"/>
    <dbReference type="EnsemblBacteria" id="ADT83775">
        <property type="protein sequence ID" value="ADT83775"/>
        <property type="gene ID" value="TERMP_00798"/>
    </dbReference>
    <dbReference type="GeneID" id="10041116"/>
    <dbReference type="KEGG" id="tba:TERMP_00798"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.800"/>
    <dbReference type="eggNOG" id="arCOG00354">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1472124_0_0_2"/>
    <dbReference type="OMA" id="VGGTTKM"/>
    <dbReference type="OrthoDB" id="79086at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="188" mass="21461" checksum="2A56093C01503160" modified="2011-05-03" version="1">MIKVAIIGAENVGKSTLMNALLGKRVSETAEIPGTTKSIIRKTFGKIKIPKTMKNPFGGADEFVLIDTAGLFDPKYEFRGKVLSEEKFKEILDEITSADIIIHMIDAQYGLHRGMEKLHHILKFRYEKPIIVVINKIDLVPRERVEELRQIVKKRLEQEPILLSLVTYEGFNDLLKALVYYAQYAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLD3</accession>
    <name>F0LLD3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467082.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83784">
        <property type="protein sequence ID" value="ADT83784"/>
        <property type="gene ID" value="TERMP_00807"/>
    </dbReference>
    <dbReference type="GeneID" id="26136259"/>
    <dbReference type="KEGG" id="tba:TERMP_00807"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.809"/>
    <dbReference type="eggNOG" id="arCOG05784">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149775_0_0_2"/>
    <dbReference type="OMA" id="EEIEWYS"/>
    <dbReference type="OrthoDB" id="120326at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="147" mass="16444" checksum="6ECF8A018D6BCAB7" modified="2011-05-03" version="1">MLYEEKITSRWIPVLVILPVVLSLSIGFWATYQAGEGIEIPLAVGAFVVPLTIDISYMRIQIDDREIRIRGALGLIIRKTVKLEDIISFEVYSGWMSCSGFIHFNMPAKGCVVLNTKRWSISFSTNNPEEIAQVLATLGIPREASDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLG2</accession>
    <name>F0LLG2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N5-glutamine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468287.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02017"/>
    <dbReference type="EnsemblBacteria" id="ADT84991">
        <property type="protein sequence ID" value="ADT84991"/>
        <property type="gene ID" value="TERMP_02017"/>
    </dbReference>
    <dbReference type="GeneID" id="10042332"/>
    <dbReference type="KEGG" id="tba:TERMP_02017"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2014"/>
    <dbReference type="eggNOG" id="arCOG00109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_6_2_2"/>
    <dbReference type="OMA" id="EWDDWME"/>
    <dbReference type="OrthoDB" id="72076at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="24"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="200" mass="22351" checksum="C6327FBCD90CCE0C" modified="2011-05-03" version="1">MAFFYYKGIKLKLHSQVYEPAEDTFLLAENLKIREGDIALDVGTGTGIIALLMAKKAKFVLGVDINPIAVELAKENARINEIKNVEFRVSDLFENVEGKFDIITFNSPYLPGEAGELKEPIDLALIGGKRGREVLDRFISQVKDYLKPNGIVQVVQSSITGVEDTIEKFTKLGFSVEITAKKRYFFEEILVITAKLNESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLJ2</accession>
    <name>F0LLJ2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-ribbon RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02047"/>
    <dbReference type="EnsemblBacteria" id="ADT85021">
        <property type="protein sequence ID" value="ADT85021"/>
        <property type="gene ID" value="TERMP_02047"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02047"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2044"/>
    <dbReference type="eggNOG" id="arCOG01989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196471_1_0_2"/>
    <dbReference type="OMA" id="KCGFEGP"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044720">
        <property type="entry name" value="HVO_2753-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011668">
        <property type="entry name" value="HVO_2753-like_ZBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40733">
        <property type="entry name" value="PTHR40733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07754">
        <property type="entry name" value="HVO_2753_ZBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HVO_2753_ZBP" evidence="1">
        <location>
            <begin position="9"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="58" mass="6470" checksum="9023CE53EA418396" modified="2011-05-03" version="1">MEAVKIPVCTSCGKEITPREHATHFICPNCGEEIIWRCESCRVLGATYKCPKCGWEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLJ7</accession>
    <name>F0LLJ7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468322.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02052"/>
    <dbReference type="EnsemblBacteria" id="ADT85026">
        <property type="protein sequence ID" value="ADT85026"/>
        <property type="gene ID" value="TERMP_02052"/>
    </dbReference>
    <dbReference type="GeneID" id="10042367"/>
    <dbReference type="KEGG" id="tba:TERMP_02052"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2049"/>
    <dbReference type="eggNOG" id="arCOG00730">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140143_1_0_2"/>
    <dbReference type="OMA" id="SEDWIFE"/>
    <dbReference type="OrthoDB" id="94232at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="146" mass="16664" checksum="73BAF052CB144BAD" modified="2011-05-03" version="1">MIVLDANILIDALFEKNEERRNLALDLFQAIKGKTVYVPRIFIVEVVSIAKRLGIGLSLEELFTLVERFNIKEENEIFNLAVYIAENVHPRAVDSYYIATAILTGSIVISNDKTLVKNCKKAGIKAFYLVEEHKEALNYLNKYIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLL5</accession>
    <name>F0LLL5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S17e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps17e</name>
        <name evidence="5" type="ordered locus">TERMP_00815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467090.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00815"/>
    <dbReference type="EnsemblBacteria" id="ADT83792">
        <property type="protein sequence ID" value="ADT83792"/>
        <property type="gene ID" value="TERMP_00815"/>
    </dbReference>
    <dbReference type="GeneID" id="26136267"/>
    <dbReference type="KEGG" id="tba:TERMP_00815"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.817"/>
    <dbReference type="eggNOG" id="arCOG01885">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176720_1_0_2"/>
    <dbReference type="OMA" id="TRDFEHN"/>
    <dbReference type="OrthoDB" id="128227at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_S17e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_S17e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="RPS17e-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="PTHR10732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="SSF116820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="67" mass="7979" checksum="6DC184B213BBBDBF" modified="2011-05-03" version="1">MGNIRQGFIKRVARELLDRYPNEFTTDFEHNKRKVQELTTVQSKTIRNRIAGYLTKLVRMKQEGKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLM2</accession>
    <name>F0LLM2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gar1-like small nucleolar rnp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467097.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00822"/>
    <dbReference type="EnsemblBacteria" id="ADT83799">
        <property type="protein sequence ID" value="ADT83799"/>
        <property type="gene ID" value="TERMP_00822"/>
    </dbReference>
    <dbReference type="GeneID" id="10041140"/>
    <dbReference type="KEGG" id="tba:TERMP_00822"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.824"/>
    <dbReference type="eggNOG" id="arCOG02466">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165884_1_0_2"/>
    <dbReference type="OMA" id="HYAKQGF"/>
    <dbReference type="OrthoDB" id="115856at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="100" mass="11670" checksum="DB78E3D45796F6FB" modified="2011-05-03" version="1">MKRLGRVSHYAKQGFLILRSNWIPSLNDPVVDKDLQLVGIVKDVFGPVKMPYIAVKPKVKAPEKYVGQVLYIDERKRKKETQKKKGKKFKRKRPAPRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLM6</accession>
    <name>F0LLM6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467101.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00826"/>
    <dbReference type="EnsemblBacteria" id="ADT83803">
        <property type="protein sequence ID" value="ADT83803"/>
        <property type="gene ID" value="TERMP_00826"/>
    </dbReference>
    <dbReference type="GeneID" id="10041144"/>
    <dbReference type="KEGG" id="tba:TERMP_00826"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.828"/>
    <dbReference type="eggNOG" id="arCOG04361">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097790_1_0_2"/>
    <dbReference type="OMA" id="PRPVWKC"/>
    <dbReference type="OrthoDB" id="113690at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019271">
        <property type="entry name" value="DUF2284_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10050">
        <property type="entry name" value="DUF2284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018748">
        <property type="entry name" value="UCP018748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="153" mass="17826" checksum="72F6E7F97B3025AA" modified="2011-05-03" version="1">MKLIYEREIDTESIVVSPRPVWKCRTCPVYGKSPSCPPYVPSWKESKEWIKHFKKALLLKFQLDYEDFEEEKRKVLLYLLQKEEELFRKGNPYVLALFPGNCNLCEVCEFEKSKQCKMPTKVRPSIDAIGIELSKIVDLNFGESVLYGLILVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLN2</accession>
    <name>F0LLN2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467107.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00832"/>
    <dbReference type="EnsemblBacteria" id="ADT83809">
        <property type="protein sequence ID" value="ADT83809"/>
        <property type="gene ID" value="TERMP_00832"/>
    </dbReference>
    <dbReference type="GeneID" id="10041150"/>
    <dbReference type="KEGG" id="tba:TERMP_00832"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.834"/>
    <dbReference type="eggNOG" id="arCOG03827">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1648389_0_0_2"/>
    <dbReference type="OMA" id="VKTWATS"/>
    <dbReference type="OrthoDB" id="88298at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="160" mass="18163" checksum="4B9282A3AE6EF3FB" modified="2011-05-03" version="1">MQEWYQSRALYEAISKLIGNRDFKTAVQIAETIPDKGIKAKAFSKITVEMAKMGEDYREVLKKTLDAIFEMENEDSITKALMSLAFEFLNLDMIDESLRIASMIKDVSNRSKIQAEVAISLAKKGKIPEALKLINDILDDDVKTWATSRLAAEINQKRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLP3</accession>
    <name>F0LLP3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydroxylamine reductase</fullName>
            <ecNumber evidence="6">1.7.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hybrid-cluster protein</fullName>
            <shortName evidence="6">HCP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prismane protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hcp</name>
        <name evidence="7" type="ordered locus">TERMP_00843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine</text>
            <dbReference type="Rhea" id="RHEA:22052"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15429"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="1.7.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </cofactor>
        <text evidence="6">Binds 1 hybrid [4Fe-2O-2S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HCP family.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.1" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00843"/>
    <dbReference type="EnsemblBacteria" id="ADT83820">
        <property type="protein sequence ID" value="ADT83820"/>
        <property type="gene ID" value="TERMP_00843"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00843"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.846"/>
    <dbReference type="eggNOG" id="arCOG02430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038344_0_0_2"/>
    <dbReference type="OMA" id="CAYAQGM"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:hydroxylamine reductase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Hydroxylam_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prismane_a-bundle"/>
    </dbReference>
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        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109:SF0">
        <property type="entry name" value="PTHR30109:SF0"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01703">
        <property type="entry name" value="hybrid_clust"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="23"/>
        </location>
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            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
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        <location>
            <position position="209"/>
        </location>
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            <name>hybrid [4Fe-2O-2S] cluster</name>
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        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="6">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
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        </ligand>
    </feature>
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        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Cysteine persulfide" evidence="6">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="455" mass="51190" checksum="36DC047E11A63C58" modified="2011-05-03" version="1">MIKVPENLDMLCNQCSMSLAGGCTIRGVCGKDPDLNSLQEALLYGIKGTSAYYYHALEVGYDDPRIGHFLAEALYSTLTNVNFDKNRFLELILENGRVHLEAMKLLDKAYVETFGRPEPVEVPTGTAEGHSILVTGHSYKALYELLRQIEEMSLEDELKVYTHAEMFPAHAYPELRKFKALYGNWGGSWLYQKKEFAEFPGVILGTSNCVQQPTKAYADRIFTVGIAGLEGVRHIEDYNFEPLIKRALETPRMEAYDGGKLLTGFHHANVLAMKDKLIELIQEGKIRHIFVVGGCDTPHKGMGYYEKLTELIPKDALILSAACGKFRYNARDYGTIEGIPRFLDFGQCNNVYSIIEIAIALANELGTDVNSLPVSIVLSWMEQKAIAILYSLLYLGIKGIYIGPRPPEFLTPNVFEILRRQFDLRLISDPERDLREMLNKGVKIEEGSPLAEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLX2</accession>
    <name>F0LLX2_THEBM</name>
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        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02097"/>
    <dbReference type="EnsemblBacteria" id="ADT85071">
        <property type="protein sequence ID" value="ADT85071"/>
        <property type="gene ID" value="TERMP_02097"/>
    </dbReference>
    <dbReference type="GeneID" id="10042412"/>
    <dbReference type="KEGG" id="tba:TERMP_02097"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2094"/>
    <dbReference type="eggNOG" id="arCOG01204">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_777601_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
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        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="356" mass="41268" checksum="58428728B4544C01" modified="2011-05-03" version="1">MKPIITDSAKEIICNELKLPFVHSVILIGSRARGDGTAESDYDLYIVVPIILLPLLFPIIKRKEKILKEKLKADVSISPLTYSRMKRGKDTLLFHIKKEGIILCGDDIRKRITIDSPRELPNSELYQYFFDAVFYFVNSLVINHESYDHRTVNRKIAKAILYCADLKLIKKGIYAGSWKIVSELSSDKRVKNAYKIIVRASLGHPLHFDPSLIRNGRDILLEIFLELTKTDYSTKDRTIDGIIEEFESKYLFQRIGVIKRIQIALFLLLMLRNSVSRRVLKMTLFGKPLDRYLHVILLYMVLVLDPEQTTFAYKKLKGILEEFGINTKEVSPIKIWKLAREFVQQYWKIACGKIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM03</accession>
    <name>F0LM03_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02128"/>
    <dbReference type="EnsemblBacteria" id="ADT85102">
        <property type="protein sequence ID" value="ADT85102"/>
        <property type="gene ID" value="TERMP_02128"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02128"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2125"/>
    <dbReference type="eggNOG" id="arCOG08355">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_353258_0_0_2"/>
    <dbReference type="OMA" id="WYKTSIV"/>
    <dbReference type="OrthoDB" id="19915at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="736" mass="84409" checksum="87361C39248FE13E" modified="2011-05-03" version="1">MLITFLLLLFLMVSLYVLFFESNCKAKLGIIAIVSLVVTYYIRVGFGRYFTTIDESYYISLIGNPVWYKTSIVSGFVVPFLLHSIRILLGIDPVSLVVYYSLAFAVLYVGIIYWAYTRVGISKKYSTISLAVLFVSSFYIWSFIQIRPQQLGILVGLSIVSLFMSIKPNKMFFIIMPVLFTLLIFTHIFSFFLFSILLMAYFVLVFIKSESSEEVFKKFLGISFAVLIAWLAFLSFPYSSRTIRTLVWLLNSMPQFDNFQLLLNYFSSLSTFAYIMLVFLIYHAGKFLHSRYLNDLVNLWESLRGILIKFSLQIIFLALIFLSVGFYIQFKLGASTYTKIYRGSVLTLVFFQLGNIFFGFMFVRGFLDKLKDNTLTEFDIMAIIWIFIGIAMLFISFFMPKGSAIWGFSNWMVRVAQYFVIFAAPTVTYALYKDIKAMGLSHLKLAISILISVLIVISMINTARPPQIYDYDIVWSDEMIDVAKEVRLSNTLMFRYNVSPYLKFAMENLLKAYGKPVEITQGSSIVLSSDAIYVYGSNYHPLSLGFFSKKRGPVIVILGTSNPKVKQYFTTLLNKEFPALIIGEIDNCEMYIKQGYPLIVMGGKLANKCTQLLEKNRAMLVYMDKDSVVTPYFTYSVPSPKKEWWNVNEGLFVIQAVKYHGAPILIIEGTNIDATVAGVWYFVNKVSQDIEKYKNTYYIVGKWIESDNKVLRFLKFDPNDNNGFSEGDTVEIIEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMB2</accession>
    <name>F0LMB2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrogen regulatory P-II-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468431.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02161"/>
    <dbReference type="EnsemblBacteria" id="ADT85135">
        <property type="protein sequence ID" value="ADT85135"/>
        <property type="gene ID" value="TERMP_02161"/>
    </dbReference>
    <dbReference type="GeneID" id="10042476"/>
    <dbReference type="KEGG" id="tba:TERMP_02161"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2157"/>
    <dbReference type="eggNOG" id="arCOG02305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082268_0_0_2"/>
    <dbReference type="OMA" id="HQIEVNF"/>
    <dbReference type="OrthoDB" id="113533at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="105" mass="11697" checksum="F866C7E53273485B" modified="2011-05-03" version="1">MKKVEAIIREEDFEKVKNALRQLGIVPLTVYPVKGRGIQGGVPPYDLLPKLKIEIVVKDEDVEKVIDAIVRNAKRGIPGDGKVFVLPVYDAIRIRTGEKGNDALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMG5</accession>
    <name>F0LMG5_THEBM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00968"/>
    <dbReference type="EnsemblBacteria" id="ADT83944">
        <property type="protein sequence ID" value="ADT83944"/>
        <property type="gene ID" value="TERMP_00968"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00968"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.971"/>
    <dbReference type="eggNOG" id="arCOG03460">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_3_2_2"/>
    <dbReference type="OMA" id="EIVLCNA"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="273" mass="31399" checksum="D24E92C70DB208AE" modified="2011-05-03" version="1">MSFEMLNQMLGSLDQKKAVKFLLQNILRIDLDNPFENVEKVLCIQPHPDDCELAVGGILAKLFLEGKEIVYLTLTDGTMGTRDPMISPQELAGIRKKEQEKAAKVIGVKKLIWFDYKDTELPYSPEVRNRIISVIRKEKPDIVFAPDPWLPYEAHPDHRNAGFLALEAVFFAPFPYINKGDLEKGLTPYEVPLVALYYTARPNYIEDVTDVFDVKLRALKEHRSQFEKNWQQWELFIRIVGMFYGKKIGAMYGEGIKVLPRLLLHVTPFAEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMH7</accession>
    <name>F0LMH7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00980"/>
    <dbReference type="EnsemblBacteria" id="ADT83956">
        <property type="protein sequence ID" value="ADT83956"/>
        <property type="gene ID" value="TERMP_00980"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00980"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.983"/>
    <dbReference type="eggNOG" id="arCOG07169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2949491_0_0_2"/>
    <dbReference type="OMA" id="AWVEIIV"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="58" mass="6481" checksum="61CF5ABE72988514" modified="2011-05-03" version="1">MGLSGAAWATLIVPTLLGILVMVLYGFWDKITGKEYYVDDEILAYDEELLKELEGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMK5</accession>
    <name>F0LMK5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0251 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01008"/>
    <dbReference type="EnsemblBacteria" id="ADT83984">
        <property type="protein sequence ID" value="ADT83984"/>
        <property type="gene ID" value="TERMP_01008"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01008"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1011"/>
    <dbReference type="eggNOG" id="arCOG02238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094511_2_2_2"/>
    <dbReference type="OMA" id="IMHSERE"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002852">
        <property type="entry name" value="UPF0251"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37478">
        <property type="entry name" value="PTHR37478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02001">
        <property type="entry name" value="DUF134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="73" mass="8259" checksum="177394C7604E4ECE" modified="2011-05-03" version="1">MTYEEFEALRLVDYEGLTQEEAGRRMGVSRGTVWRALSSARKKVAQMLVEGRELIILAQGNEVPKTQSSDNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LML8</accession>
    <name>F0LML8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467295.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01021"/>
    <dbReference type="EnsemblBacteria" id="ADT83997">
        <property type="protein sequence ID" value="ADT83997"/>
        <property type="gene ID" value="TERMP_01021"/>
    </dbReference>
    <dbReference type="GeneID" id="10041338"/>
    <dbReference type="KEGG" id="tba:TERMP_01021"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1024"/>
    <dbReference type="eggNOG" id="arCOG00463">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115699_1_0_2"/>
    <dbReference type="OMA" id="IPRYFLG"/>
    <dbReference type="OrthoDB" id="119956at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd10441">
        <property type="entry name" value="GIY-YIG_COG1833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002837">
        <property type="entry name" value="DUF123"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37460">
        <property type="entry name" value="PTHR37460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01986">
        <property type="entry name" value="DUF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="13"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="147" mass="17303" checksum="7B9B1F459CDE1C84" modified="2011-05-03" version="1">MRGSYFLVIKVERDMIVRTKRKEFPLKAGYYVYVGSAMNSLEKRVERHFRKDKKLHWHVDFLLKEAKLLRAYLIPSDAKIEEELSMEVSKFGKPIEGFGASDLRIDSNLHYFKDEPDKILTSILQRLGLKWKSVKSPNEVRELEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMM7</accession>
    <name>F0LMM7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-methyladenine DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467304.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01030"/>
    <dbReference type="EnsemblBacteria" id="ADT84006">
        <property type="protein sequence ID" value="ADT84006"/>
        <property type="gene ID" value="TERMP_01030"/>
    </dbReference>
    <dbReference type="GeneID" id="10041347"/>
    <dbReference type="KEGG" id="tba:TERMP_01030"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1033"/>
    <dbReference type="eggNOG" id="arCOG00464">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010556_0_0_2"/>
    <dbReference type="OMA" id="EPYGKWK"/>
    <dbReference type="OrthoDB" id="88480at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="107"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="273" mass="32032" checksum="7A7BA732E1D9951B" modified="2011-05-03" version="1">MIDLKKVTHEMIKNKTWKYERGIFWQALDYGIVGFDGENFYLPYYLSSKEKKDAKEKIKFILGLNTDLERFYGEIQDSKFAFLIEEFYGLTVPAAPYKYQALVETIAQQQVSFEFAMRTIRNLVELAGRKIGSLYVFPKPENIAKLSVEEIKKAKLGYRAGYIKELTELHLKGKLDLSLEQFTEQEAIKYLTKFRGIGKWSAELFLLYGLRKNVYPAGDLGLRRGIAKIFGKRTKEVKEKDVREIIEPYGKWKSLLAFYILCYDRKTEMERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMR5</accession>
    <name>F0LMR5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467342.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01068"/>
    <dbReference type="EnsemblBacteria" id="ADT84044">
        <property type="protein sequence ID" value="ADT84044"/>
        <property type="gene ID" value="TERMP_01068"/>
    </dbReference>
    <dbReference type="GeneID" id="10041385"/>
    <dbReference type="KEGG" id="tba:TERMP_01068"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1071"/>
    <dbReference type="eggNOG" id="arCOG01407">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_5_2"/>
    <dbReference type="OMA" id="APVPWFP"/>
    <dbReference type="OrthoDB" id="83551at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="177"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="344" mass="39124" checksum="F1D42B3406740114" modified="2011-05-03" version="1">MRILMVGHYPPHTGGIARHLDKLVRELRKRHEVHVLTYGPIIPRKFESEFVHQVKPPNIFGVRGISFTFLASKKIRELHKKYRFDIIHAHYIGTTTYAAILAKKHVKVPVVITAHGSDLDFMSRLPLGTYYVKKSLSEADRIIAVSHYLAKKALSLGAKKVYVVPNGVGKLQYDGRERKFITFIGALRHYKSPETVLKLAEAFPNEQFLIVGDGPLKKVLEEKAPSNVKFLGYRRDIENILSKTKILILPSKREGFGLVIVEANASEVPVIGRKVGGIPELIREGKNGVTFEKFEELIEKFQGMLTPKKQRKMGDFGKKISEKYTWKAITRQIEAIYESTLHFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMS1</accession>
    <name>F0LMS1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467348.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01074"/>
    <dbReference type="EnsemblBacteria" id="ADT84050">
        <property type="protein sequence ID" value="ADT84050"/>
        <property type="gene ID" value="TERMP_01074"/>
    </dbReference>
    <dbReference type="GeneID" id="10041391"/>
    <dbReference type="KEGG" id="tba:TERMP_01074"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1077"/>
    <dbReference type="eggNOG" id="arCOG02462">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_3_0_2"/>
    <dbReference type="OMA" id="GHPTHKT"/>
    <dbReference type="OrthoDB" id="93116at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="188" mass="20444" checksum="D04D8CE65BEBC5A3" modified="2011-05-03" version="1">MIVDLTKTLSEELEVFPGDPEIKIKEWTSLEKEGYYMNLLCFGEHSGTHVDAPAHFIKGGKAVDGLPLEKFFGRAIVVDVSNGQGEVIIKEVPKTDLEGKIVLFYSGGRELSVELAEFLVNAGIKAVGTDGMSIGNEEVHRVLLSAEIPIFENLANLEKLIGKNFTFIAFPLKIENGSGSPVRAVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMT2</accession>
    <name>F0LMT2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S_layer_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01085"/>
    <dbReference type="EnsemblBacteria" id="ADT84061">
        <property type="protein sequence ID" value="ADT84061"/>
        <property type="gene ID" value="TERMP_01085"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01085"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1088"/>
    <dbReference type="eggNOG" id="arCOG07087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034059_0_0_2"/>
    <dbReference type="OMA" id="DRYCTRK"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032560">
        <property type="entry name" value="DUF4932"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022651">
        <property type="entry name" value="S_layer_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16286">
        <property type="entry name" value="DUF4932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05124">
        <property type="entry name" value="S_layer_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S_layer_C" evidence="1">
        <location>
            <begin position="404"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="542" mass="62917" checksum="D6DB4CCE515EC41D" modified="2011-05-03" version="1">MKRASLILCFLLLISQTPLIKAEEQPQVVVEVNPNLELFAVVYILAFNGSDDFITAPQDYVRNVLTYFAPYKGHVAVKSMQQMFPKDLPNYIKDENIWNWASSLAVRDYLGDQGNLPDFYAELSDFARESNFMEFYNAHREEYERALTPIEDIFKELNFIEELENRSGEKYAEYRVELSYSLLIHLHSRQTVTKAYMIGSIPRIYLENLRYTGLPNVQAIINYTFRAFFIHEFAHAFLDSDRLGISSEYRFIYQKILEELPLMAYERDFSTSGAYLNENLVEAFTHYYLGEHYNDIIAEYSILKDATIGYILVGDLAKAFQENISFEQIPEVVGKLVTKDNLSRYFNSKMPVNGFWATNKIYKDKKVIIVYGTQNPDERGNEYDKESALMLADWLRSVGISVEVKSDKELTNEDLKSNLIVIGGPAANELTKNLTKELVVRFSFNDEWRLVKNFTAVENPISFIFSNGSIRMAKLNTPISQEYPLGVVQTLRNPWNKEKFMIVIAGVDRYCTRKMLRYFNYNSSYLIKGRTFFEEGFYFQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMU7</accession>
    <name>F0LMU7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Flap endonuclease 1</fullName>
            <shortName evidence="11">FEN-1</shortName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fen</name>
        <name evidence="15" type="ordered locus">TERMP_01100</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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</entry>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="318" mass="36800" checksum="A6D19A93E23D0579" modified="2011-05-03" version="1">MGHNFRFCPYCGGELKENYKFCPYCGKPLESSESIEKPISESAVVKEHIQQISDRPKEEFSLSYIPRGKPEPKKVKRKVKVTGVDKDLRFNGSKGTKFGKLTLNEALALFERLPREYPYFSEDANPIVFELNDGALRIGLRTDGQYQITSVLPIRGTVIGFTLLEHASFEEALGAIERFYKEKDFCKNAYYAKERYLEKQEVREGKYLLKMPGIFVRYDGDVKIPSVLYLTAKGLEFYGHEGIYYSMEIPENLPYFAREGIRRIKFNKKRTEMEVTYVDDSGKKGKFTYVFLIPEEGDRYYQVLSSHFPGKVKIGGWF</sequence>
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    <accession>F0LN26</accession>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="144" mass="16767" checksum="129545B491A94439" modified="2011-05-03" version="1">MRLILKPLFEVELPPEFVDILKAKIKGREIKEGDVIEIDLLGKPLKFEVIYAEPKEFRVREDTKIELSSEKPLTLDFEFNKVVKNIIFLEKSIVLIFEDEVLVLTEDGHKIYNEKFEGLKEVRGTKNILVIVHGEGKKLRLIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN32</accession>
    <name>F0LN32_THEBM</name>
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        <name evidence="10" type="ordered locus">TERMP_01185</name>
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        <dbReference type="NCBI Taxonomy" id="391623"/>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
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                <person name="Marteinsson V.T."/>
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                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="1 6 9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467459.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01185"/>
    <dbReference type="EnsemblBacteria" id="ADT84161">
        <property type="protein sequence ID" value="ADT84161"/>
        <property type="gene ID" value="TERMP_01185"/>
    </dbReference>
    <dbReference type="GeneID" id="10041502"/>
    <dbReference type="KEGG" id="tba:TERMP_01185"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1188"/>
    <dbReference type="eggNOG" id="arCOG00496">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_2"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="46017at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6 7">
        <location>
            <begin position="19"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 7">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <begin position="358"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT84161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="416" mass="46931" checksum="1E17BDCBD2F5FCBD" modified="2011-05-03" version="1">MFRLPDFDYHNKTVFLRVDLNSPVRNGKIISDARFKAILPTLLYLLEHDAKVVIATHQSKPYNEDYITTEQHAEILSSLISREVEYVEDIFGRYAREKIKSLKPGDAVILENLRFAAEEIKQKPIEECERTHFVRKLAPLLDYVVNDAFAAAHRSQPSLVGFARIKPMIMGFLMEKEVRALIKAYESTEKPKVYVLGGAKVGDSLRVAENVLKQEKADLILTGGLVGHIFTLAKGYNLGVANIEFLERKGLLKFVDLAEKLLDEFYPYIRTPVDFAIDYRGERLEVDLLSDEKWLFDKYPILDIGSRTVEKYSQILNQAKIIVANGPMGVFEIEEFALGTIGVFKAIGESEAFSIVGGGHSIASIYKYNIQGITHISTGGGAMLAFFAGEKLPVLKAFRISYEKFKDKVKRESVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN54</accession>
    <name>F0LN54_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02220"/>
    <dbReference type="EnsemblBacteria" id="ADT85193">
        <property type="protein sequence ID" value="ADT85193"/>
        <property type="gene ID" value="TERMP_02220"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02220"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2214"/>
    <dbReference type="eggNOG" id="arCOG09755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1286382_0_0_2"/>
    <dbReference type="OMA" id="FLAPWVV"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="197" mass="22894" checksum="F22E548B68B0120D" modified="2011-05-03" version="1">MKAAKNFKKKHKKVFDVILYGSTTLGKELPNDFDFMVITKKANEEERFDLAFEFREILLDLGFSHEKLDVKAINLESLWDPNYLATPGIIISGFSLTKGKPIHELMNGESYSLFSINVQRLDRSQRKKFNYALKGRDGSGGILKDLNGVFLAPWVVLIPIENTYKFKEFLDYWIVEYEVYLMYGTKSMMRTIGYLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN55</accession>
    <name>F0LN55_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747416.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02221"/>
    <dbReference type="EnsemblBacteria" id="ADT85194">
        <property type="protein sequence ID" value="ADT85194"/>
        <property type="gene ID" value="TERMP_02221"/>
    </dbReference>
    <dbReference type="GeneID" id="10549045"/>
    <dbReference type="KEGG" id="tba:TERMP_02221"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2215"/>
    <dbReference type="eggNOG" id="arCOG08595">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172294_0_0_2"/>
    <dbReference type="OMA" id="VGICDYI"/>
    <dbReference type="OrthoDB" id="111271at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="111" mass="13221" checksum="6E9C186C8A3534F3" modified="2011-05-03" version="1">MPINLDDLKANIQECIEVGEIAFKRGKYNSATIMYFKAMVGICDYIIKRDLGLEPKNHAERFAVLRLHYRDLYKVVNKYFDFYRDAYERRITKREVGELRNAVLRLADRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN74</accession>
    <name>F0LN74_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
            <plasmid evidence="2 3">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747435.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02240"/>
    <dbReference type="EnsemblBacteria" id="ADT85213">
        <property type="protein sequence ID" value="ADT85213"/>
        <property type="gene ID" value="TERMP_02240"/>
    </dbReference>
    <dbReference type="GeneID" id="10549064"/>
    <dbReference type="KEGG" id="tba:TERMP_02240"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2234"/>
    <dbReference type="eggNOG" id="arCOG00547">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031965_0_0_2"/>
    <dbReference type="OMA" id="HGYHPDW"/>
    <dbReference type="OrthoDB" id="12902at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="513" mass="58781" checksum="962B59DBD2442E0A" modified="2011-05-03" version="1">MKITIYDGADTIGGTKIHIEENGNGLLLDFGMNFAKYSLYYEEYLGERTSRGIYDLWKLNLIPKLNIYRKDLIPKDLALEISQCSKPQVNAVLISHAHLDHVGNITLLDENIPIVGSPTTIAILKAINDTSKGGNHFGIELPYYKIRKIKDSEGYIIESDRKADYPSRKIVLIEYVQPLHEFLFYRPGQESPKAKKIIPNEVKTLDEEDLGFEVKAFHVDHSIYGATAYIIEGDISLAYTGDFRLHGGKGDETRKFIKAAKNSSVLITEGTRVGRDEHGNTSEQEVYENALKIVEDAKGLVIADFSPRNFERLESFKKIAENTGRELVVTAKDAYFLHALQLVDGINRLEGLRIYGNFKATQDKWESIIVHGNYAEQYISPFEIRENQENYILCFSFYDMPHLLDIMPDGGTYIYSSSEAFGEEQVFSFLRLWNWLQYFGFEVHGFEVDKYGMPIFEKGLHASGHISREELREVIEEIDPDYVIPVHTEKLEWFRENWGEEAVVLKNGESWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN83</accession>
    <name>F0LN83_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
            <plasmid evidence="2 3">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747444.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02249"/>
    <dbReference type="EnsemblBacteria" id="ADT85222">
        <property type="protein sequence ID" value="ADT85222"/>
        <property type="gene ID" value="TERMP_02249"/>
    </dbReference>
    <dbReference type="GeneID" id="25394648"/>
    <dbReference type="KEGG" id="tba:TERMP_02249"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2243"/>
    <dbReference type="eggNOG" id="arCOG01744">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_898995_0_0_2"/>
    <dbReference type="OrthoDB" id="74329at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="309" mass="35179" checksum="9EE10847D4B60932" modified="2011-05-03" version="1">MMGLTHIVFSIFFYGATASIFNLPITRGILAIVAFGALVPDIDNPTSSIGMLFLPLSKWINKRYGHRTITHSLWFWLGGTCLSLAIAYPVGELTYAVAFSMGTLSHLIADGMTKTGVMLFWPNSRPVYFIPQRLTVKTNSRQELVVFIIFSFLAVSTVGIYYIGWRSVFRSAMPTFVGARNLYLEKGCREGEAYRVFVKLTYCEGFCYDLEGEIIGAGYERFYLATPRGYFEVTENRVPKVYWMKTRGPYYTKILPLRDVMNQKLQLSPFDVVLTNKVPRYIKDVDLNEILKENPGAEVKIYKYKGALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGV0</accession>
    <name>F0LGV0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00011"/>
    <dbReference type="EnsemblBacteria" id="ADT82989">
        <property type="protein sequence ID" value="ADT82989"/>
        <property type="gene ID" value="TERMP_00011"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00011"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.10"/>
    <dbReference type="HOGENOM" id="CLU_3194687_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT82989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="45" mass="5285" checksum="7CC40D0D86A9266C" modified="2011-05-03" version="1">MFFRESLQFKSFSTIKRVLTSPISITESWDIDNGKTHGIKFCIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGV1</accession>
    <name>F0LGV1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00012"/>
    <dbReference type="EnsemblBacteria" id="ADT82990">
        <property type="protein sequence ID" value="ADT82990"/>
        <property type="gene ID" value="TERMP_00012"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00012"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.11"/>
    <dbReference type="eggNOG" id="arCOG03661">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003442_2_1_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_38N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_38C" evidence="3">
        <location>
            <begin position="527"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro38C2" evidence="4">
        <location>
            <begin position="828"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT82990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="901" mass="103956" checksum="C6A9509FA90A6C8C" modified="2011-05-03" version="1">MKIKHLEAYKAKEMVVMKEKVIYFLPHTHWDREWYLPFQIFRARLLHVIDVLLEMLEKFPEFKFNLDGQVIALEDYLEIEKDPQKTETLFSMIRNGRISVGPFYVLPDEFLISGETFIRNFLIAQRVLEELSLPSMKVAYFPDMFGHSAYVPTLIRGLGMDSVLIWRGVGDKCRDTEFIWKGPDGSEVLCINIIRGYWNLGVPSSDYHEFKRMVEKEVEFLFKHSPSGHILLMAGNDHRFPFPLLPDFVRKLNSEGLKCKIVTLDEYAQILQRMELSLKKIEGEMRDSKYAPILKDVASARIHLEQRSHLIEKELVSIVEPLSAIAYVYSLPLGSVLNLLFYAWKLFLKTLPHDDICGCSIDQVHKEMEVLQDQVLQLIKVIKLELVNKIAETLVKNGTENGNLQLFVFSPFERKTRTVVEKELYMPEELPENLLERLVVVEKGKKLPTVVEYIKERVFDGIQVLSNTFEEEYIARFLTEEAPPQLKKGKVVKIKFEVELPPMGFKIFNIEFDSGILRPEEVSKNVIETAFLKVNVNEDGTLTIEDRRTGRMYRNLFFLEDAEDVGDEYNYSPSKNPEIVTTLGQKAKIKRITEDSIGFSVEVEHELRLPESFDFERERRSEEKVSMPVNITYVIYKRSPRVDIKIEFENIAKDHRLRVHIPLPVHVETNISDDYFGIVTRPNKIEISEDLSQYSEVPESRYPMQNFVYIADDTGGAGISTRGLKEYETIQKDGEVEVALTLLRSVGMLSRPGLLTRSEDAGPSFLTPEAQCLGNHIAEFSVWFTYKHDLIEAYNFSRRYQIFPPVFSIRGIRETEISLLSLEPECLILSSFKVSEDGDGTIIRFYNVKDMDVNATVKLGWAPKEVWLANMAEKPIKKIKTNGNIIKLKVGANEVITLKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGV7</accession>
    <name>F0LGV7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Altronate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466294.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00018"/>
    <dbReference type="EnsemblBacteria" id="ADT82996">
        <property type="protein sequence ID" value="ADT82996"/>
        <property type="gene ID" value="TERMP_00018"/>
    </dbReference>
    <dbReference type="GeneID" id="26137871"/>
    <dbReference type="KEGG" id="tba:TERMP_00018"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.17"/>
    <dbReference type="eggNOG" id="arCOG05318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084161_3_0_2"/>
    <dbReference type="OrthoDB" id="110381at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11613">
        <property type="entry name" value="SAF_AH_GD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044144">
        <property type="entry name" value="UxaA/GarD_SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="2">
        <location>
            <begin position="10"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT82996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="89" mass="9988" checksum="F9E4FA6DBA0783AE" modified="2011-05-03" version="1">MKFVIMNRKDNVATAIVPLKKGEKVVVGGRKIILLEDIPQGHKFAIRDINAGDFIIKYGEIIGIATRNIKAGEYVHIHNVRSRYQGAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH03</accession>
    <name>F0LH03_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01235"/>
    <dbReference type="EnsemblBacteria" id="ADT84211">
        <property type="protein sequence ID" value="ADT84211"/>
        <property type="gene ID" value="TERMP_01235"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01235"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1237"/>
    <dbReference type="eggNOG" id="arCOG00139">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131321_0_0_2"/>
    <dbReference type="OMA" id="HAYREHT"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="174" mass="19435" checksum="C80C5663ADB8DE44" modified="2011-05-03" version="1">MLLIEALFTLAWSLAPEIVLLNYVIFKLHKTIFEVMLIEGAISVATITATYVSERIPKDKGFRVIGSGMLLLSIYALIMSFSPPFWLVLAAYFIGRFGDTLAFPFYRSWMFSLIPKEKASEFHAAISSYRRLIGLFTPFVAGALASIHATLPYAASFLLFLLIGVLFIEAARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH13</accession>
    <name>F0LH13_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467519.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01245"/>
    <dbReference type="EnsemblBacteria" id="ADT84221">
        <property type="protein sequence ID" value="ADT84221"/>
        <property type="gene ID" value="TERMP_01245"/>
    </dbReference>
    <dbReference type="GeneID" id="10041562"/>
    <dbReference type="KEGG" id="tba:TERMP_01245"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1247"/>
    <dbReference type="eggNOG" id="arCOG00845">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1021649_0_0_2"/>
    <dbReference type="OMA" id="ARVFDEW"/>
    <dbReference type="OrthoDB" id="49774at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="272" mass="32032" checksum="03C804E5B6C9EF8E" modified="2011-05-03" version="1">MKPLIREAKPEDKPFIEEIAKLTWEGEDYLARVFENWLKDGNFYVLELEGKVIGTAKLTILPDKVGWLEGLRVHPNYQKRGFGRVLHNFMLQRGEELAEKGIITTLEFSTYFLNKESITMAKKDGFKIVERFYYIKRALGDGEHPRPSKIHSLDELDYKDYIPYGWKFLHKCKESLKWLNKKAEIREYSGFKFSYAPMYENEPTFTPFRLSAESIETLLPAMSFEAEKIGYDSIDIMLPEDKQDLIEPLKELGFKNWTNFKEPDVLVFRMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH26</accession>
    <name>F0LH26_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01258"/>
    <dbReference type="EnsemblBacteria" id="ADT84234">
        <property type="protein sequence ID" value="ADT84234"/>
        <property type="gene ID" value="TERMP_01258"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01258"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1261"/>
    <dbReference type="eggNOG" id="arCOG10610">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1286405_0_0_2"/>
    <dbReference type="OMA" id="FKHAQPC"/>
    <dbReference type="OrthoDB" id="71896at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="264" mass="29147" checksum="8311B27E88FA53D6" modified="2011-05-03" version="1">MKRGIVVAWILFIVFASMPFIVNWSLKKGSEVSPVPKAPSENITVEGVIYVGYVTSHTGSDMLCVVPGEAYVPSAGKMVTLNVTVKFKHAQPCPYSDWKIVAENLKNVEIVKETKTELKDPYTAFKQYVVKVLGNGSIDIVFKYGTGCPYGTEERATVKFYIGTPPENVNVSTSNPKELPATNVFNITGIVKEINLNGKYVVVGNTTVYIKGRWHDEYGVEYQWRVMLGEVLKVGESVKIVATEENGKLVASEIIVNGHKYTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH31</accession>
    <name>F0LH31_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467537.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01263"/>
    <dbReference type="EnsemblBacteria" id="ADT84239">
        <property type="protein sequence ID" value="ADT84239"/>
        <property type="gene ID" value="TERMP_01263"/>
    </dbReference>
    <dbReference type="GeneID" id="10041580"/>
    <dbReference type="KEGG" id="tba:TERMP_01263"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1266"/>
    <dbReference type="eggNOG" id="arCOG00499">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044538_3_0_2"/>
    <dbReference type="OMA" id="WHHDHIY"/>
    <dbReference type="OrthoDB" id="73329at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="37"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="248" mass="27675" checksum="69BDDD69BAE21D3F" modified="2011-05-03" version="1">MIVYFIGTGGSEGIPAHLCTCRTCEEARRLGFAQRKPSTLAVITKNNEAILIDVGTDIRDLLHVPLKAILLTHWHHDHIYGLYKLRWIAQETELYAPEGHADALILNDPKNLKPKTIKAGDVLKIDSLKITALKLNHEIETLGFLIEEDGKRFALLYDTKGIPPETMAILREKSPDVAVVDATYAPGVNDPYHNNVDEGAEVGSEIAEEVYLSHISHKNMPFLQLLAYVKKRYGSKVRVAYDGLIVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH42</accession>
    <name>F0LH42_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division FtsH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01274</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467548.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01274"/>
    <dbReference type="EnsemblBacteria" id="ADT84250">
        <property type="protein sequence ID" value="ADT84250"/>
        <property type="gene ID" value="TERMP_01274"/>
    </dbReference>
    <dbReference type="GeneID" id="10041591"/>
    <dbReference type="KEGG" id="tba:TERMP_01274"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1277"/>
    <dbReference type="eggNOG" id="arCOG01308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_2"/>
    <dbReference type="OMA" id="DFVEWLH"/>
    <dbReference type="OrthoDB" id="2808at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="3">
        <location>
            <begin position="107"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="215"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="550"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="796" mass="88986" checksum="CA8E7803EB84614B" modified="2011-05-03" version="1">MADKREIKLKVASAYQRDVGRGIVRIDRKAMRTIGVQPGDIVEIIGTKNTAAVVWPAYPEDEGLDIIRMDGTIRKNAGVGLGDEVTVRKAEVKEAKKVVLAPTEPIRFGADFVDWLHSRLIGRPVVRGDYIKIGVLGQELTFVVTATTPAGIVQITEFTDFTVSEKPVKEVAKTAALGVTYEDIGGLKDVIQKIREMIELPLKHPEIFEKLGIEPPKGVLLYGPPGTGKTLLAKAVANEANAHFIAINGPEIMSKYYGESEERLREVFKEAEENAPSIIFIDEIDAIAPKRGEVTGEVEKRVVAQLLALMDGLKSRGKVIVIGATNRPDALDPALRRPGRFDREIEVGVPDRQGRKEILQIHTRGMPIEPEFRKSEVKRILEGLRGDERFRDIINRAIEKVERAKDEKEIQDILKNLDERLYDEVKHRLIDALLEELADKTHGFVGADLAALAREAAMAALRRLIKEGKIDFEAEHIPKEVLEELKVTKRDFYEALKMIEPSALREVLLEIPNVRWDDIGGLEEVKEALREAVEWPLKYPEAFQALGINPPKGILLYGPPGTGKTLLAKAVATESEANFIGIRGPEVLSKWVGESEKNIREIFRKARQAAPTVIFIDEIDAIAPRRGTDVNRVTDRLINQLLTEMDGIEENSGVVVIAATNRPDILDPALLRPGRFDRLILVPAPDEKARYEIFKVHTRKMPLSEDVDLKELAKRTEGYTGADIAAVCREAAMNAMRRALKEGIIKPGVKMDEVKQKVKVTMKDFEEALEKVGPSVSKETMEYYKKIEEQFKKMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH63</accession>
    <name>F0LH63_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal RNA small subunit methyltransferase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466323.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00047"/>
    <dbReference type="EnsemblBacteria" id="ADT83025">
        <property type="protein sequence ID" value="ADT83025"/>
        <property type="gene ID" value="TERMP_00047"/>
    </dbReference>
    <dbReference type="GeneID" id="10040366"/>
    <dbReference type="KEGG" id="tba:TERMP_00047"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.48"/>
    <dbReference type="eggNOG" id="arCOG00973">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_7_0_2"/>
    <dbReference type="OMA" id="EPEENEF"/>
    <dbReference type="OrthoDB" id="32049at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="6">
        <location>
            <begin position="29"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="120"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="310" mass="35341" checksum="9811BA41DFB4F592" modified="2011-05-03" version="1">MLERLFSLGYSKTFAERYYQLWGERAIRIAEAMEKPLPRCFRVNTLRTEIPKLTKLLNKKGFQFKRVPWAKEGFCLTREPFSITSTPEYLSGLLYIQEASSMYPPIALEPKPGEVVADMAAAPGGKTSYMAQLMKNGGIIYAFDVGEERLKEMRLNLSRLGVTNVVVFHKSSLYMGELGIEFDKILLDAPCTGSGTIHKNPERKSNRTLDDIKFCQNLQMKMIKVALENLKKGGVLVYSTCSLEPEENEFVVQWVLDNFEVELLPLRYGEPALVKPFGIELSEELKKARRFYPDKHGTSGFFVAKIRKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH87</accession>
    <name>F0LH87_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466347.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00071"/>
    <dbReference type="EnsemblBacteria" id="ADT83049">
        <property type="protein sequence ID" value="ADT83049"/>
        <property type="gene ID" value="TERMP_00071"/>
    </dbReference>
    <dbReference type="GeneID" id="10040390"/>
    <dbReference type="KEGG" id="tba:TERMP_00071"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.71"/>
    <dbReference type="eggNOG" id="arCOG03789">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102063_1_0_2"/>
    <dbReference type="OMA" id="NFDSLHV"/>
    <dbReference type="OrthoDB" id="77118at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005489">
        <property type="entry name" value="DUF257"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03192">
        <property type="entry name" value="DUF257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="225" mass="25670" checksum="412C9CDF62E6682B" modified="2011-05-03" version="1">MRRAFEAVTRIMDSLKMGETVLLIYDESLIPEFSFLFFVEYASQKGVPVIVDDILDSLYVIKQHLEFIGIDTKFFENITVIKVGGTNIVGNVRQHIPLEGAYREKYRLAVREVYKEKSNAINLVLGIENLFYLSTKPSDVMDVISELISFLGEKSRIAVYIINKNITEKAPVNPLPFFERIASTVIYTESHPRKAVLRIGKCSSLELVGKSLVIELDDLLQYWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH96</accession>
    <name>F0LH96_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA decarboxylase, alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466356.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00080"/>
    <dbReference type="EnsemblBacteria" id="ADT83058">
        <property type="protein sequence ID" value="ADT83058"/>
        <property type="gene ID" value="TERMP_00080"/>
    </dbReference>
    <dbReference type="GeneID" id="10040399"/>
    <dbReference type="KEGG" id="tba:TERMP_00080"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.80"/>
    <dbReference type="eggNOG" id="arCOG02705">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_6_2_2"/>
    <dbReference type="OMA" id="YAYAECT"/>
    <dbReference type="OrthoDB" id="21634at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="264"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="522" mass="57186" checksum="B26D71BF26B9C6A9" modified="2011-05-03" version="1">MSMEEKVNELYEKKRKILQMGGEAKIQKQHEKGKLTARERIEKLLDPGSFVEIGMFVKHRNTEFGLDKMELPADGVITGYGTIDGRLVFVYAQDFTVMGGSLGEMHAMKIKRVMELALEAGAPIIGLNDSGGARIQEGVDSLKGYGEIFKMNTILSGVVPQITAIMGPCAGGAVYSPAIGDFILMVDNPATFMFITGPQVVKAVTGVEVSPTQLGGAMVHAQKSGQAHLIGKSDEEVLMLIRKLLSYLPSNNMEKPPRVKTNDPPFRKSDRLYEIVPDDPNKGYDVRQVIYEIVDRDANGNPDFLEILPYYAPNAVVGFGRFNGQTVGIVANNPIHLAGVLDIDSSDKIARFVRTCDAFNIPIVTLVDVPGYLPGVQQEYGGIIRHGAKVLYAYAEATVPMVTVILRKAYGGAYLAMGSKHLGADFVFAWPTAEIAVMGPEGAANIIFRKEIAKAENPEEFRQQKIREYREKFANPYVAAGRGYIDDVIDPAETRGKIIMALEALESKRVKLPPKKHGNIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHH5</accession>
    <name>F0LHH5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0282 protein TERMP_01327</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0282 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467600.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01327"/>
    <dbReference type="EnsemblBacteria" id="ADT84302">
        <property type="protein sequence ID" value="ADT84302"/>
        <property type="gene ID" value="TERMP_01327"/>
    </dbReference>
    <dbReference type="GeneID" id="10041643"/>
    <dbReference type="KEGG" id="tba:TERMP_01327"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1327"/>
    <dbReference type="eggNOG" id="arCOG00969">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079268_0_0_2"/>
    <dbReference type="OMA" id="YHYDHHT"/>
    <dbReference type="OrthoDB" id="36408at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01406">
        <property type="entry name" value="UPF0282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014426">
        <property type="entry name" value="UPF0282_hydrls"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF4">
        <property type="entry name" value="PTHR43546:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004944">
        <property type="entry name" value="UCP004944_hydrls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="300" mass="34504" checksum="E9C8DE252CD482A6" modified="2011-05-03" version="1">MKIVPLASESLGVRSLATYVKIDKTGILIDPGVALGPKRYSLPPAKAELEALMKAREKIQSYAKKADIVTISHYHYDHHTPFFEGIYESSSPEKAREIYEGKILLIKHPKENINFSQRKRAWNFLKGVEKIAEKVEYADGRFFDFGDFIMEFSPAVPHGSEGTKLGFVIMVMIDDGTKRLVHASDIQLLNRKAVEWIIKQMPDILITGGPPTYLEGYRVKDAWNTGLKNLNEIIKETNAQIILDHHLIRDKRYPEFFAHLEKEPLTFARFLKREDKPLEAYRKELHKIKKGEDVDLPFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHH9</accession>
    <name>F0LHH9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467604.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01331"/>
    <dbReference type="EnsemblBacteria" id="ADT84306">
        <property type="protein sequence ID" value="ADT84306"/>
        <property type="gene ID" value="TERMP_01331"/>
    </dbReference>
    <dbReference type="GeneID" id="10041647"/>
    <dbReference type="KEGG" id="tba:TERMP_01331"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1331"/>
    <dbReference type="eggNOG" id="arCOG00349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_6_4_2"/>
    <dbReference type="OMA" id="DVFEMND"/>
    <dbReference type="OrthoDB" id="111853at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="68" mass="7490" checksum="99CE022630DD9CC7" modified="2011-05-03" version="1">MAKWKVWVDRDVCIGDAICASLCPDVFEMDDEGKSFAKVEIVGEDLIDCVNEAAEACPVSCIHVEQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHL4</accession>
    <name>F0LHL4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L14e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl14e</name>
        <name evidence="4" type="ordered locus">TERMP_00120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00120"/>
    <dbReference type="EnsemblBacteria" id="ADT83098">
        <property type="protein sequence ID" value="ADT83098"/>
        <property type="gene ID" value="TERMP_00120"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00120"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.121"/>
    <dbReference type="eggNOG" id="arCOG04167">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183474_0_0_2"/>
    <dbReference type="OMA" id="RRCNIKH"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06088">
        <property type="entry name" value="KOW_RPL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00721">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023651">
        <property type="entry name" value="Ribosomal_L14e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_protein_L14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041985">
        <property type="entry name" value="RPL14_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="PTHR11127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="90" mass="9696" checksum="D5B704EDEBC18D0B" modified="2011-05-03" version="1">MPAIDIGRIAVVIAGRRAGQKVVVVDIIDKNFVLVTGAGLNKVKRRRMNIKHIEPLPEKINIPRGASDEEVKAALGAGWNQLGLVSSQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHN5</accession>
    <name>F0LHN5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00142</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00142"/>
    <dbReference type="EnsemblBacteria" id="ADT83119">
        <property type="protein sequence ID" value="ADT83119"/>
        <property type="gene ID" value="TERMP_00142"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00142"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.143"/>
    <dbReference type="eggNOG" id="arCOG01206">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG05024">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1243025_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="5">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="219" mass="25656" checksum="17880713A3A23DA4" modified="2011-05-03" version="1">MRTLEEIQKILQTHKEELYKKFGVKRIGIFGSYSRGEQKETSDIDILVEFGRPIGFIEFIKLQEYLESLLGVKVDLTTKKALKKPIRKQNSPRGEIHMRNPYLYIGDILRSIEKIKRYTAGMSFGDFMRDEKTIDAVLRNLEVIGEAAKNVPEEIKQKYPQIPWKEIAGMRDRLIHAYFGVDLEIVWQTIISDLPSWNLNYLKLSRRRVRNESSRFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHQ3</accession>
    <name>F0LHQ3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Proteasome core protein PsmA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">psmA</name>
        <name evidence="6" type="ordered locus">TERMP_00160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466435.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00160"/>
    <dbReference type="EnsemblBacteria" id="ADT83137">
        <property type="protein sequence ID" value="ADT83137"/>
        <property type="gene ID" value="TERMP_00160"/>
    </dbReference>
    <dbReference type="GeneID" id="26135489"/>
    <dbReference type="KEGG" id="tba:TERMP_00160"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.161"/>
    <dbReference type="eggNOG" id="arCOG00971">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_2"/>
    <dbReference type="OMA" id="FQVEYAR"/>
    <dbReference type="OrthoDB" id="57654at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03756">
        <property type="entry name" value="proteasome_alpha_archeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_A">
        <property type="entry name" value="Proteasome_A_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019982">
        <property type="entry name" value="Proteasome_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03633">
        <property type="entry name" value="arc_protsome_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="5">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="260" mass="28943" checksum="070FD9213853E63A" modified="2011-05-03" version="1">MAFVPPQAGYDRAITVFSPDGRLFQVQYAREAVKRGATAVGVKCKEGVVLAVEKRVTSRLIEPESYEKIFQIDDHIAAASSGIIADARVLVDRARLEAQIYRLTYGEPVPLTVLVKKICDLKQMHTQYGGVRPFGAALLMAGVNEKPELFETDPSGAYFEWKAVAIGSGRNTAMAIFEEKYRDDMTLEDAIKLAVLALAKTMEEPSPENIEVAVITVKEKKFKKISKEKVAKCLEEAIKEAEEEEVAEKEEDYTELDSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHQ4</accession>
    <name>F0LHQ4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation protein SDO1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466436.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00161"/>
    <dbReference type="EnsemblBacteria" id="ADT83138">
        <property type="protein sequence ID" value="ADT83138"/>
        <property type="gene ID" value="TERMP_00161"/>
    </dbReference>
    <dbReference type="GeneID" id="10040479"/>
    <dbReference type="KEGG" id="tba:TERMP_00161"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.162"/>
    <dbReference type="eggNOG" id="arCOG04187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043216_2_0_2"/>
    <dbReference type="OMA" id="AVNPQMD"/>
    <dbReference type="OrthoDB" id="59861at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018023">
        <property type="entry name" value="Ribosome_mat_SBDS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="PTHR10927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="SSF109728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="SSF89895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01267">
        <property type="entry name" value="UPF0023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBDS" evidence="3">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="SBDS_C" evidence="4">
        <location>
            <begin position="101"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="236" mass="26824" checksum="CA81485F8016B90B" modified="2011-05-03" version="1">MPISVDKAVIARLKTHGETFEILVDPYLARDFKEGKDVPIEEILATPYVFKDAHKGDKASEHEMEKIFGTSDPYEVAKIILKKGEVQLTAQQRREMLEEKKKQIATIIHKHAVDPRTGYPHPVDRILRAMEEAGVRVDVFKDAEAQVPDVIKAIRRFLPLKIEVKVIAVKIPSDYVGKAYGEVRKFGTIKREEWASDGSWMFLIEIPGGVEEEFYEKLNALTKGNVVTKLIERKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHS6</accession>
    <name>F0LHS6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83160">
        <property type="protein sequence ID" value="ADT83160"/>
        <property type="gene ID" value="TERMP_00183"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00183"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.184"/>
    <dbReference type="HOGENOM" id="CLU_215629_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="46" mass="5010" checksum="C3C0EF5C5E1F370F" modified="2011-05-03" version="1">MEEKTKKVVIWLIDKFVDFIIITAGVALGIIIAAGFIAKHMIAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHV9</accession>
    <name>F0LHV9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467657.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01384"/>
    <dbReference type="EnsemblBacteria" id="ADT84359">
        <property type="protein sequence ID" value="ADT84359"/>
        <property type="gene ID" value="TERMP_01384"/>
    </dbReference>
    <dbReference type="GeneID" id="10041700"/>
    <dbReference type="KEGG" id="tba:TERMP_01384"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1384"/>
    <dbReference type="eggNOG" id="arCOG01430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_2"/>
    <dbReference type="OMA" id="WMADYGF"/>
    <dbReference type="OrthoDB" id="47519at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="2">
        <location>
            <begin position="15"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="390" mass="43467" checksum="8BACE0BC73F455F6" modified="2011-05-03" version="1">MVENYTKLGIYDNILQTIGKTPLVRLRKIERYFNLKNELYAKVEFFNPGGSVKDRIGKYMIEGAKKEGKIVQGAVIIEPTSGNTGVGLALVAAVEGYMTVFTMPDKMSTEKELLLKAMGAFVIRTPTAVAPGDPNSYYKVAEAVRNLIWKKGRAVTREELKEIVEYVQRLVNEEKLDELKAILEDEVEETPYAYIPNQYFNSYNPLAHYETTAREIWEQTGGEIDYLFAGIGTGGTITGIGRYLKERKKDVKVIGVDPVGSIYSLVKKGMSLEEALKKAHPYLVEGIGEDLLPETVDLSLVDDMVVVNDQQAFSMTRFLARKEGILAGGSSGAALYGAVKYLKEKGVEGKKVVVIFPDTGRNYLTKVFNDEWLIANGFEVDDEKVLEVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI16</accession>
    <name>F0LI16_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl11</name>
        <name evidence="8" type="ordered locus">TERMP_00193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466468.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00193"/>
    <dbReference type="EnsemblBacteria" id="ADT83170">
        <property type="protein sequence ID" value="ADT83170"/>
        <property type="gene ID" value="TERMP_00193"/>
    </dbReference>
    <dbReference type="GeneID" id="26135523"/>
    <dbReference type="KEGG" id="tba:TERMP_00193"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.194"/>
    <dbReference type="eggNOG" id="arCOG04372">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_4_0_2"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="98187at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="6">
        <location>
            <begin position="70"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="164" mass="17416" checksum="BB1BBBB4EC7B926E" modified="2011-05-03" version="1">MPKQVVEVLVEGGKATPGPPLGPAIGPLGLNVKLVVDKINEATKDFAGMQVPVKIIVDPATKQFEIEVGTPPVSQLIKKELGLEKGSSEPVRNIVGNLTMEQVIKIAKAKKHQMLAADLKAAAKEVIGTALSMGVTVEGKDPRVVQKEIDEGVYDEIFAKAEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI56</accession>
    <name>F0LI56_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00233"/>
    <dbReference type="EnsemblBacteria" id="ADT83210">
        <property type="protein sequence ID" value="ADT83210"/>
        <property type="gene ID" value="TERMP_00233"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00233"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.233"/>
    <dbReference type="eggNOG" id="arCOG05717">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2730609_0_0_2"/>
    <dbReference type="OMA" id="FEARPYV"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="77" mass="9332" checksum="80DB076B1950AE05" modified="2011-05-03" version="1">MWEEGDMEGLEKKIEKALFEARPYVEYYDRLKETVNKLKDKISDEEGFRKLVEKEISKAQEPFKTDLRIFLQKFEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI61</accession>
    <name>F0LI61_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable glycine dehydrogenase (decarboxylating) subunit 1</fullName>
            <ecNumber evidence="3">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Glycine cleavage system P-protein subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Glycine decarboxylase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Glycine dehydrogenase (aminomethyl-transferring) subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvPA</name>
        <name evidence="4" type="ordered locus">TERMP_00238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GcvP family. N-terminal subunit subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466513.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00238"/>
    <dbReference type="EnsemblBacteria" id="ADT83215">
        <property type="protein sequence ID" value="ADT83215"/>
        <property type="gene ID" value="TERMP_00238"/>
    </dbReference>
    <dbReference type="GeneID" id="10040556"/>
    <dbReference type="KEGG" id="tba:TERMP_00238"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.238"/>
    <dbReference type="eggNOG" id="arCOG00077">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_0_2_2"/>
    <dbReference type="OMA" id="MYDGASA"/>
    <dbReference type="OrthoDB" id="52784at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00712">
        <property type="entry name" value="GcvPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023010">
        <property type="entry name" value="GcvPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42806">
        <property type="entry name" value="PTHR42806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006815">
        <property type="entry name" value="GcvPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="451" mass="50518" checksum="E8ED6A892B6DDA6D" modified="2011-05-03" version="1">MGKQYLPNLAHKEEMLKEIGFDSIDELFSDVPREVMHEFNLPEGKSEYEVFLEMNQVLNKNKTVLEMPSFLGAGTYFHYVPAHVKYLIERSEFLTAYTPYQAEISQGMLQALFEYQSLIAELVGLEIVNASMYDWGTALGEAALMAARVTKKNKFVVPKHMSPERKKVLETYVAGAGMEIVYVDWNEKGQIDLEKLKENVENAAGVYIEMPNFFGLIEENIVEVGEIAHDSRALFVVGVDPTILGIVEAPGELGADVVIGEAAFFGNPMNFGGPRAGIFATRNDRKLIRQMPGRIIGMTKDADGKRAFVMTLQTREQHIRRAKATSNICSNEALVAVAAAIHLASLGPQGLRKLGEIILKNTAYFKKRISEVAELPFDGINFKDVLVQFEVPYDVIHERLLEKNIHGGYYVKPHFPELGESALFAVTETTRKEWIEKLIVALKEIIAEAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIB0</accession>
    <name>F0LIB0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ATP-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467738.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01465"/>
    <dbReference type="MEROPS" id="S16.A12"/>
    <dbReference type="EnsemblBacteria" id="ADT84440">
        <property type="protein sequence ID" value="ADT84440"/>
        <property type="gene ID" value="TERMP_01465"/>
    </dbReference>
    <dbReference type="GeneID" id="10041781"/>
    <dbReference type="KEGG" id="tba:TERMP_01465"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1465"/>
    <dbReference type="eggNOG" id="arCOG01937">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027628_0_0_2"/>
    <dbReference type="OMA" id="VMMTGMI"/>
    <dbReference type="OrthoDB" id="80994at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="6">
        <location>
            <begin position="27"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="249"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="642" mass="70915" checksum="14098E4F25E570D3" modified="2011-05-03" version="1">MKKLLPFLALILLISPLALAQCPAEGHTVVLKAPAVSKTANGDLIGVATEFVITVAPGSGHVYVETWPLAEVDMQASARLAAQVAGRVLGVDMSKYDVFIQVKADSPIIGGPSAGGTMTVGIIAALKGWKLRNDVMMTGMINPDGTIGPVGGILEKASAAHSVGAKLFLIPEGQRIQVVQKTEQKQIGPLVQITTKEEKVDVVQYAKERWGLEVKEVKDIYEAVYYFTGHKIEKPQAPENIKIDTSFLKEDAERDYKNTTEYYKQVEKKLKESDVSYTTYSYLKAALEDANQTLKDAKDALDSGMYYTALSKDFQARIIIRHVDWYLDVQNEKDIEKLLNSVNDDIKNTENYVSNLTIRGTTMLQAVAASEERIEQAKSLLKDAWSDYYKGDYWNAVSNAAFAYERVQTAKFWAKLGERYAKGDVISRDVIKETAREYLDNARLVVTYITSMFGESLMQGLVDELNKGEQYYEDGKYSAALFSAMEARIRAEVILDTLGIDNETVLTDKLQQMKEDAKTAIAIAQSKGVYPILGMAYYEFAQSYEKQGGTENIQTAMIFYQYAKETAMMFLPKTVPKITESTITPQIIHPSNTQTPMDTQTASTTTASAVPEKNVPTSLLGGIGVLGVLFGLIIGIVLGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LID9</accession>
    <name>F0LID9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane bound hydrogenase MbhE-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467767.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01494"/>
    <dbReference type="EnsemblBacteria" id="ADT84469">
        <property type="protein sequence ID" value="ADT84469"/>
        <property type="gene ID" value="TERMP_01494"/>
    </dbReference>
    <dbReference type="GeneID" id="26136982"/>
    <dbReference type="KEGG" id="tba:TERMP_01494"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1494"/>
    <dbReference type="eggNOG" id="arCOG03077">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171166_0_1_2"/>
    <dbReference type="OMA" id="GLGGEDW"/>
    <dbReference type="OrthoDB" id="117506at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="100" mass="11167" checksum="FCC3008D7BA5DB1A" modified="2011-05-03" version="1">MNRTFGALALLFILGVLLIVANPQYGLKFGLGGSDWQKYRYTDQYYIEHGVEEVGGTNIVTDIVFDYRGYDTLGEATVLFTAIAGAVALLRPWRRDEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIE0</accession>
    <name>F0LIE0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF4040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_01495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
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            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="88" mass="9338" checksum="2378D4D831743BB7" modified="2011-05-03" version="1">MNVLTVDMVIQFGILIGILIAAYLTISFRDLLSAALASAAMSLLLSLEFYMLHAPDVAIAEAAVGAGVVTAIVVYGIAKTERWEREGP</sequence>
</entry>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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    </evidence>
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    </evidence>
    <sequence length="330" mass="38370" checksum="469CF2A7D2FFA6FF" modified="2011-05-03" version="1">MKDYLIPEEKFRVLFFIGKGGVGKTTSAAATSIALAKKGYKTLIVSIDPAHNLGDVFMMRLNDKPKKVIKNLYAMELDMEKLIQSYLEHLEKNLKHMYKYLTVINLEKYFEILRFSPGIEEYATLEAIREILIDGEKWDIIIFDTPPTGLTLRVLALPRISLIWTNKLIEIRRKILERRKAIEKIQGERKFVIEGEEYKLPSDEEEDAVMKELKKYKEEIEFVHRIITNPKKTTVVAVMNPEMLPLYETERAYESLNKFKISFRLIVLNKILELEELPSKLKVKIEAQKKVLELVRNKFKGVDIVKIPMFEEEPRGLELLEKIGGAIIGD</sequence>
</entry>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
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    <sequence length="566" mass="61701" checksum="A915EA98FB2CD394" modified="2011-05-03" version="1">MNSTLIILVAALIYAGLYMSYGRSLQNKVVKADPNRPTPAHRLYDGVDYVPAHPIVLYGHHFASIAGAGPIVGPAVAMAWGWLPSLLWVWFGNVFIGAVHDYLALMSSVRYDGKSIQWIAGRLMSRRTSMAFELYVWFALVLVIAAFAAVISGIFVGTPEAATASLLFLIDAIILGYLLYKMKINFYAGTAIGIILLIIAVWLGFKFPIAASKHTWMIVLGIYIVIASSLPVWVLLQPRDYLNAYILWFGLLLGGVAFIIVGLKGVGTFSAPAFTTWSANVVGGKPSPFWPTVPLVIACGALSGFHSIVGSGTTSKQLDNELHGLLVGYGGMFTEGFLSTIVIASIAVYGLKVFQTMNIPVDTTNWGAQYAIQVVKHGIKVGIFAKSYAYGLQDALGIPFKTGAVFASLWVSAFALTTLDTATRLGRFAWQEIMDMVHGPEILKNKWIASIILAIFGIYMAWGGSWLIIWPAFSGMNQMLASIAMMTASLWVAKVQRPEGAWKWAVVIPALFLWITVTAALVWFLIVIKPGFWVSLITVVGLLLNLLLVVDWYAAWKKPAEEYAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIL8</accession>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00315"/>
    <dbReference type="EnsemblBacteria" id="ADT83292">
        <property type="protein sequence ID" value="ADT83292"/>
        <property type="gene ID" value="TERMP_00315"/>
    </dbReference>
    <dbReference type="GeneID" id="26135656"/>
    <dbReference type="KEGG" id="tba:TERMP_00315"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.315"/>
    <dbReference type="eggNOG" id="arCOG02102">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150646_6_3_2"/>
    <dbReference type="OMA" id="KISAMSF"/>
    <dbReference type="OrthoDB" id="114771at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="77" mass="8213" checksum="218500FE9A9D8549" modified="2011-05-03" version="1">MYVHLTQMKEGEEGVVVDIHGGIGARQKLIGMGITPGTRIRVLKSSPPGPIIIAVGSSRIAIGRGIADKIIVRRELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIM0</accession>
    <name>F0LIM0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LexA-like DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466592.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00317"/>
    <dbReference type="EnsemblBacteria" id="ADT83294">
        <property type="protein sequence ID" value="ADT83294"/>
        <property type="gene ID" value="TERMP_00317"/>
    </dbReference>
    <dbReference type="GeneID" id="10040635"/>
    <dbReference type="KEGG" id="tba:TERMP_00317"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.317"/>
    <dbReference type="eggNOG" id="arCOG04939">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2519959_0_0_2"/>
    <dbReference type="OMA" id="CPLKKIC"/>
    <dbReference type="OrthoDB" id="118511at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="90" mass="9900" checksum="3B0A91B6859A208C" modified="2011-05-03" version="1">MVNIEEVLELIKGGYTNPKEIARVMGINVEEVSGIIKILESLGYIEKVEFGSSVCSRCPMKKICSGSCIHFKGQIYQISEKNSSNSSKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIM9</accession>
    <name>F0LIM9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative leucyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466601.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00326"/>
    <dbReference type="EnsemblBacteria" id="ADT83303">
        <property type="protein sequence ID" value="ADT83303"/>
        <property type="gene ID" value="TERMP_00326"/>
    </dbReference>
    <dbReference type="GeneID" id="10040644"/>
    <dbReference type="KEGG" id="tba:TERMP_00326"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.326"/>
    <dbReference type="eggNOG" id="arCOG01890">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062630_0_0_2"/>
    <dbReference type="OMA" id="TCHFAIG"/>
    <dbReference type="OrthoDB" id="48170at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="350" mass="39010" checksum="B58A56922E1D2034" modified="2011-05-03" version="1">MKLKDVSKIAMHEVIDVQKGEEVLIITNPGEVLEISLSLFSAAKEFHAKPTIIIQEPKTSLEFAERSVIEAIKSEPDIVISITEKKLGKDAFGLNIGYVGRDNQKYTHIFEKLLWGDRRIRSFWSPGITVDMYLRAVPIDYERLRYEARVLAEILDKGKEVHVATEKGTDLWINIKGRKAFKDDGDFRKPGKGGNLPAGEVFISPAVGKSEGVIVFDGTLGLGGESVLPKNTVKVHVKEGFVQKIEGKEEAKKLEEAIKEAEKRALKMGKEELAKNAWHLGELGIGLNPRAKMSGKLLEDEKLRNTIHIAIGANYDNDAPALNHFDCLILNPTVEVDGERIMEKGKFLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIP4</accession>
    <name>F0LIP4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA (Adenine57/58-N1)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467794.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01521"/>
    <dbReference type="EnsemblBacteria" id="ADT84496">
        <property type="protein sequence ID" value="ADT84496"/>
        <property type="gene ID" value="TERMP_01521"/>
    </dbReference>
    <dbReference type="GeneID" id="10041837"/>
    <dbReference type="KEGG" id="tba:TERMP_01521"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1521"/>
    <dbReference type="eggNOG" id="arCOG00978">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025402_0_1_2"/>
    <dbReference type="OMA" id="VVYPKDA"/>
    <dbReference type="OrthoDB" id="64860at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="104"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="253" mass="28961" checksum="9721ABE66D79C434" modified="2011-05-03" version="1">MIAEDQKVLLVDPRGKRYLISAKKQEFHTDLGKIDLSEIIGKNFGDIIESHKGYKFKILKPRIVDFIDKMKRGPQIIHPKDAAQIVAFAGISPGDFIVEAGVGSGALTLFLANIVGPNGKIVSYEVREDFARLAWKNIEWAGFDDRVTIKLKSIYDGIDEKEVDHIILDLPQPERVVEHAVEALKPGGYFVAYTPCINQVARLYEKLREFREYFMRPKTIECLVREQEVREECIRPRTRMIAHTGYITFARKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIQ7</accession>
    <name>F0LIQ7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467807.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01534"/>
    <dbReference type="EnsemblBacteria" id="ADT84509">
        <property type="protein sequence ID" value="ADT84509"/>
        <property type="gene ID" value="TERMP_01534"/>
    </dbReference>
    <dbReference type="GeneID" id="10041850"/>
    <dbReference type="KEGG" id="tba:TERMP_01534"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1534"/>
    <dbReference type="eggNOG" id="arCOG00084">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097042_1_0_2"/>
    <dbReference type="OMA" id="FIATCPP"/>
    <dbReference type="OrthoDB" id="82309at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="47"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="164" mass="18802" checksum="FBA8C668BE446B53" modified="2011-05-03" version="1">MTTLLVTVPSGREGDASLELEWALGDVKIRRTRWRGVLIVKTGLKKEEALEILKGFETTAIFKIIPLEKFVRSRKEDIIEEGFKLAKARIKEGESFAVRCKRRGNWIRSSKEIEIELGAKIKENLNAVVNLDNPDWYVWIEVLGNRTAISIIKPDEIIKKEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIT5</accession>
    <name>F0LIT5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="9" type="ordered locus">TERMP_01562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467835.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01562"/>
    <dbReference type="EnsemblBacteria" id="ADT84537">
        <property type="protein sequence ID" value="ADT84537"/>
        <property type="gene ID" value="TERMP_01562"/>
    </dbReference>
    <dbReference type="GeneID" id="10041878"/>
    <dbReference type="KEGG" id="tba:TERMP_01562"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1562"/>
    <dbReference type="eggNOG" id="arCOG00353">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_2_0_2"/>
    <dbReference type="OMA" id="AEMKTGR"/>
    <dbReference type="OrthoDB" id="33372at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="8">
        <location>
            <begin position="186"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="217"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="238"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="306"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="341"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="428" mass="49145" checksum="DDB51DC764DA39C2" modified="2011-05-03" version="1">MKAIGVIRHSPRKRINKAEFEELLRSAGYEVLAIVEQVREEHPKYNIGPGKLQEIKKLAEELKPDKVIFANQLTPSQAFNIAKELRVDIIDKWQLVLEIFEKRAHSKEAKLQVELANLRYELPLVREAIRRAKMGEQPGFKGMGEYQIHQYLKHIRYRMGKIRKELERIREDREVKRKRREEVGFIIVALAGYTNAGKSTLLNALAREEIPAKDQMFTTLDTTTRRFKVNQKRVLVTDTVGFIDDLPPFIVEAFHSTLEEITKADIILLVLDVSEPWSEIKRKFLASLKILRELKALDKPIIVVLNKQDLTTNVDVEDKKGAIKELADKRGVVIFDVVSISAKLNRLEELYRALERAILTLPKYKSFEIVVKEKGKVSQVIALINSIGEILDIEYGEATKILAYIQVGMIKSLTKLGVEIKYSPIDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIY0</accession>
    <name>F0LIY0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkyl hydroperoxide reductase subunit C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466624.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00349"/>
    <dbReference type="EnsemblBacteria" id="ADT83326">
        <property type="protein sequence ID" value="ADT83326"/>
        <property type="gene ID" value="TERMP_00349"/>
    </dbReference>
    <dbReference type="GeneID" id="10040667"/>
    <dbReference type="KEGG" id="tba:TERMP_00349"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.349"/>
    <dbReference type="eggNOG" id="arCOG00310">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_2"/>
    <dbReference type="OMA" id="CSDQWPG"/>
    <dbReference type="OrthoDB" id="98508at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="167" mass="19345" checksum="2F2039909BBDCED5" modified="2011-05-03" version="1">MADSRILHPRPEGRDFRKVKVGDTAPDFSLKDQNGEEFKLSDYRGKKVLLSFHPLAWTSICAQQMKDLERNYRRFEELNVVPVGISVDSVPCKKAWADHLGLRKLRILSDFWPHGKVAKLYGVFRESNGFSERANIIVDEEGKVVFVKVYPIRELPDIEEILKFLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ09</accession>
    <name>F0LJ09_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466653.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00378"/>
    <dbReference type="EnsemblBacteria" id="ADT83355">
        <property type="protein sequence ID" value="ADT83355"/>
        <property type="gene ID" value="TERMP_00378"/>
    </dbReference>
    <dbReference type="GeneID" id="26135721"/>
    <dbReference type="KEGG" id="tba:TERMP_00378"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.378"/>
    <dbReference type="eggNOG" id="arCOG00348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075000_1_0_2"/>
    <dbReference type="OMA" id="ICLMGET"/>
    <dbReference type="OrthoDB" id="92721at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004426">
        <property type="entry name" value="CHP00062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00162">
        <property type="entry name" value="TIGR00162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="264" mass="29771" checksum="D50C5E2871DC0906" modified="2011-05-03" version="1">MKETVVVVYEKPEIYDPIFIEGLPGIGLVGKLAAEHLIQELNAKKFAELYSPHFMHQVLIKKDSTVDLMKNEFYYWKSPDEEHRDLIIITGDTQVPPTDSYGHFEVVGKMLDFVEQFGTREIITMGGYQVPELQGEPKVLASFTDLETKERYKQILGDMVVFREDEGGAIVGAAGLLLGIGKLRGMRGACFLGESLGYIVDAKAAKSVLTVVAKVLNLEIDMTALEERAKETEEILRKVQEMQRAMFEQQLPQPSHEEEDRGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ40</accession>
    <name>F0LJ40_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ordered locus">TERMP_00409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466684.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00409"/>
    <dbReference type="EnsemblBacteria" id="ADT83386">
        <property type="protein sequence ID" value="ADT83386"/>
        <property type="gene ID" value="TERMP_00409"/>
    </dbReference>
    <dbReference type="GeneID" id="26135749"/>
    <dbReference type="KEGG" id="tba:TERMP_00409"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.409"/>
    <dbReference type="eggNOG" id="arCOG04449">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_4_2_2"/>
    <dbReference type="OMA" id="FLYGMVR"/>
    <dbReference type="OrthoDB" id="62389at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="128"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="266" mass="30999" checksum="E60164AF2686CD81" modified="2011-05-03" version="1">MRIALKIAYDGSKFYGFQRQPGLRTVEGEIIRVLQKLDVIESPENANFKGASRTDRGVSALGNVIAFNTENPKLAQPRVLNHHLRDIWVLGVAQVSDDFHPRFWAKSKIYRYYLVDEGFDVNAMKECARLFVGTHDFSAFARVEKFKDPIREVNRLEIIPRGDLIIIEIEGKSFLWEMVRRIVTALKLCGFGIVETEDIRKMLEGRTDKKLPPSPPENLVLWEIKYENIIFQIDEYSLRKIKQEFFERFSSFLVKAGMFKDWLSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJA7</accession>
    <name>F0LJA7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maltodextrin-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467927.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01654"/>
    <dbReference type="EnsemblBacteria" id="ADT84629">
        <property type="protein sequence ID" value="ADT84629"/>
        <property type="gene ID" value="TERMP_01654"/>
    </dbReference>
    <dbReference type="GeneID" id="10041970"/>
    <dbReference type="KEGG" id="tba:TERMP_01654"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1653"/>
    <dbReference type="eggNOG" id="arCOG00154">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_17_1_2"/>
    <dbReference type="OMA" id="WAHDWIG"/>
    <dbReference type="OrthoDB" id="74127at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006060">
        <property type="entry name" value="Maltose/Cyclodextrin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00181">
        <property type="entry name" value="MALTOSEBP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="449" mass="49332" checksum="46F501EBD69D18C8" modified="2011-05-03" version="1">MKKALFALLLVAVLAVAVVASGCIGGGTTTPTTSSPTQTTTSETTSSPTKTTTSSPTETTTTTTTESEKVPSGKVVIWHAMQPNEAQVFESIIEEFMAEYPSIEIVLEQKPNLEDALKAAIPAGQGPDLFIWAHDWIGKFAEAGLLEPIDEYITPDILDKFSGMAKEAIEYGGHYYAMPFAAETVAIIYNKKMISEPPKTFDEMKAIMEKYYKPDEEKYGIAYPINAYFISAWAHAFGGYYFDDKTKQPGLDKPETIKGFEFFFKNIFPYMAPTGDYNTQQAIFLEGRAPMMVNGPWSIGSVKDAGIDFGVAPLPPIIENGKEYYPRPYGGVKLIYFAKGIKNKDAAWFFVKWFTTNPEVAKTLAKELGYIPVLKEVLNDPEIQSDPVLYGFGKAVEYAIPMPKSPEMGSVWGPVDTAITEILKDPQNADIAAILKAQNEEILKAISGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJB0</accession>
    <name>F0LJB0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amylopullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467930.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01657"/>
    <dbReference type="EnsemblBacteria" id="ADT84632">
        <property type="protein sequence ID" value="ADT84632"/>
        <property type="gene ID" value="TERMP_01657"/>
    </dbReference>
    <dbReference type="GeneID" id="10041973"/>
    <dbReference type="KEGG" id="tba:TERMP_01657"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1656"/>
    <dbReference type="eggNOG" id="arCOG03771">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005603_0_0_2"/>
    <dbReference type="OMA" id="QDGYGPD"/>
    <dbReference type="OrthoDB" id="149at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027552">
        <property type="entry name" value="CGP_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019248">
        <property type="entry name" value="Glucodextran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09985">
        <property type="entry name" value="Glucodextran_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04288">
        <property type="entry name" value="CGP_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="3">
        <location>
            <begin position="33"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Glucodextran_C" evidence="4">
        <location>
            <begin position="789"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="Glucodextran_C" evidence="4">
        <location>
            <begin position="1033"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1272"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1282"/>
            <end position="1330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1352" mass="153649" checksum="975B2C0E6546E583" modified="2011-05-03" version="1">MRKVFSLLAIFLVLFSTLAVPAKGEEPKPLNVIIVWHQHQPYYYDPIQDIYTRPWVRLHAANNYWKMAYYLSKYPEVHATIDLSGSLIAQLADYMNGKKDTYQVITEKIANGEPLSIDDKWFMLQAPGGFFDHTIPWNGEPVTDKNGNPIRSFWKRYTELKDKRNKAFAMYGGLPLDEQKKKITSEFTEQDYIDLAVLFNLAWIDYNYIMMHDDLKAIYEKRNTGGYTRDDVKTVLQHQMWLLNHTFEEHEKINLLLGNGNVEVTVVPYAHPIGPILNDFGWESDFDAHVKKADELYKKYLGGGKVEPKGGWAAESALNDKTLEILAENGWQWVMTDQLVLERMGIPYSIGNYYKPWVAEFNGKKIYLFPRNHDLSDRVGFRYSGMNQYEAVEDFINELLKIQKQNYDGSLVYVVTLDGENPWEHYPYDGKIFLEQLYKRLTELQKQGLIRTLTPSEYIQLYGDKANKLTPKELKRLDLSTANKAKKLLEAKSLNELYDMVGVTEPQQWIESSWVDGTLSTWIGEPQENIAWYWLYLARKALFENKDKMSPEEWNKAYEYLLRAEASDWFWWYGNDQDSGQDYTFDRYLKTYLYEIYKLAGIKPPSYLYGNYFPDGQPYRVRELSGLGEGEKKTYSSLSASAKEVEVYFDKDGMHFVIKGAPEQFEISIYEKGKIIGNTFTLLQGTPKYEYSLFPYIRDSIGLMITKHVVYKDGKAEIYEAKDYETSEKVGEATVEKLSDGVEIIVPFDYIETPEDFYFAVSTVKGGNLEVITTPVELRLPMEVKGVPIVDITDPEGDDYGPGTYTYATDKVFVKGAFDLLRFRMLEQTDAYVMEFYFKELGDNPWNGPNGFSLQIIEVYFDFKEGGNTSAIKMFPDGPGSNVQLDPDHPWDVAFRIAGWDYGNIIVLSNGTAIQGELQISADPVKNAIIVRVPKKYLQINEDYGLYGAVLVGSQDGYGPDKWRPVAVEAEQWKIGGAEPDAVINNVAPRVMDLLAPKGFKPTQEEQLKSYDAKNIKLATVKMLPLLKTGIVIKDPEGDDHGPGTYTYATNKVFVPHHLDLLKFKMTEENEYWKLEFYFKELGDNPWNGPNGFSLQIIEVYFDFKEGGNTSAIKMFPDGPGSNVDLDPNHPWDVALRIAGWDYGNIIVVPGKKPIQGELKISADPTRNAIIVELPKKYLQIDEDYGLYAAVLVGSQDGYGPDKWRPVAVQAEEWKGGGAEPDAVINNVAPRVYDLLVPEGYKPTQEEMLSSYDAKAGKRAVVLMIPIIKGTKSEEKPTPTETKTETTTTKATTTTTQTTTTKETKTTTTSTPSRTTTTSPTPSESSPTESGICGPALIIGLALLPVLLKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJH3</accession>
    <name>F0LJH3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">crcB</name>
        <name evidence="7" type="ordered locus">TERMP_00462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="F0LJH3"/>
    <dbReference type="STRING" id="391623.TERMP_00462"/>
    <dbReference type="TCDB" id="1.A.43.1.7">
        <property type="family name" value="the camphor resistance or fluoride exporter (fluc) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83439">
        <property type="protein sequence ID" value="ADT83439"/>
        <property type="gene ID" value="TERMP_00462"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00462"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.462"/>
    <dbReference type="eggNOG" id="arCOG04701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114342_2_3_2"/>
    <dbReference type="OMA" id="FLMFESF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="118" mass="12979" checksum="80BFCF137F6525B1" modified="2011-05-03" version="1">MLQIALGGALGALARFYISGLLPVYRDFPVGTLIVNSIASFLLGYISGLMFFGYDISPKTRVFFGIGFCGSLSTFSTFSYETFVLLREGEYLKASLNVFSNVSLTLLLVFLGFMLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJJ0</accession>
    <name>F0LJJ0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas2</name>
        <name evidence="9" type="ordered locus">TERMP_00479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466754.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00479"/>
    <dbReference type="EnsemblBacteria" id="ADT83456">
        <property type="protein sequence ID" value="ADT83456"/>
        <property type="gene ID" value="TERMP_00479"/>
    </dbReference>
    <dbReference type="GeneID" id="26136005"/>
    <dbReference type="KEGG" id="tba:TERMP_00479"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.479"/>
    <dbReference type="eggNOG" id="arCOG04194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161124_0_1_2"/>
    <dbReference type="OMA" id="LTHVQNS"/>
    <dbReference type="OrthoDB" id="118787at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="85" mass="10067" checksum="6F0157085380E2D3" modified="2011-05-03" version="1">MYVVIVYDVNVSRVNKVKKFLRQYLHWVQNSVFEGEITLAEFERIREGILNLIDENEDSVVIYKLRSKPKRESLGVEKNPLEDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJP2</accession>
    <name>F0LJP2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted RNA-binding protein involved in ribosomal biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84684.1"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT84684">
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    </dbReference>
    <dbReference type="GeneID" id="26137090"/>
    <dbReference type="KEGG" id="tba:TERMP_01709"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1708"/>
    <dbReference type="eggNOG" id="arCOG00993">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1599075_0_0_2"/>
    <dbReference type="OMA" id="FYPNIEF"/>
    <dbReference type="OrthoDB" id="82147at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0113" evidence="1">
        <location>
            <begin position="97"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="170" mass="20142" checksum="6E733F8AA7355F98" modified="2011-05-03" version="1">MVQGLRYRRVSSWEFDLILREAEKYGELRHSFFAVVEGKFRDIYAVNEKVWEEIENLKLKPYSFGTFVGTIKVDENLVEKFYPNIEFFYFVDIKKNYAILKPKAAFLFTTGKDVPKRGIKEYIWEGTRKLVLFDENGVILGIGRIQPNSERTFIKNITDIGEFIRRHRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJS6</accession>
    <name>F0LJS6_THEBM</name>
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        <submittedName>
            <fullName evidence="7">Na(+)/Ca(2+)-exchanging protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01743"/>
    <dbReference type="EnsemblBacteria" id="ADT84718">
        <property type="protein sequence ID" value="ADT84718"/>
        <property type="gene ID" value="TERMP_01743"/>
    </dbReference>
    <dbReference type="GeneID" id="10042059"/>
    <dbReference type="KEGG" id="tba:TERMP_01743"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1742"/>
    <dbReference type="eggNOG" id="arCOG02881">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007948_0_1_2"/>
    <dbReference type="OMA" id="TRDYGVM"/>
    <dbReference type="OrthoDB" id="45269at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00367">
        <property type="entry name" value="TIGR00367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="164"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="304" mass="32678" checksum="66D46619DD8A6BE1" modified="2011-05-03" version="1">MIQEFIVFIVGLILLIKGSDEFVEAGSRVAKGFGVSEFLIALILASIATTLPEVTVSAIAAFEGNSGIALGNAVGSALANIALILGISAMIMPLEVDEIAWRNSLFMFLVTVYAWFLMRDGVISRLEGFTLILIYLGFLYYLYRKHIAIEDIEGGRSRSVRRDIVILFLSGAVVVIGARMVVTSAVTIARSLGISEVVIGLTLVSIGTSLPELANSLAATLKKIPNISVGNIVGANILDILMVIGIASMIRPITVDAGIFSFTMPLTLFVMGILTLSLRMTNKISRAISAVLLTIYAYFLYSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJV1</accession>
    <name>F0LJV1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose ABC transport system ATP-binding RbsA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00511"/>
    <dbReference type="EnsemblBacteria" id="ADT83488">
        <property type="protein sequence ID" value="ADT83488"/>
        <property type="gene ID" value="TERMP_00511"/>
    </dbReference>
    <dbReference type="GeneID" id="26135975"/>
    <dbReference type="KEGG" id="tba:TERMP_00511"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.511"/>
    <dbReference type="eggNOG" id="arCOG00186">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_2"/>
    <dbReference type="OMA" id="VGREMSH"/>
    <dbReference type="OrthoDB" id="6733at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="261"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="509" mass="56297" checksum="1C591F39261DCFF4" modified="2011-05-03" version="1">MEEVPIIDMKGIVKIYPDGTKALKGVDFSVKQGEIHGLLGENGAGKTTLMKILSGMLPPTEGKIYVKGREVQFKSPADALANGIGMVHQHFTLVEVFDALHNIILGMEGHGHFSKIDVDNARKKLQKLMDELNFQVPLDVPVENLPVGVQQRIEILKVLYRNVDVLILDEPTAVLTPIEVKELFDVLRTLKEQGKTIIFISHKLREVMEITDRVTVLRKGEVIGTVNTSEATPQLLARMMVGRDVVLRIQKPPKEPGEPILRVEDLWVKGDRGEDAVKGLSFEVRAGEIFGIAGVEGNGQTELIEAITGLRKIEKGKIILNGKDITGRPPKELYNLGVAHIPEDRTHMGLILDMTVAENAVLGLHWREEFTGILNSIRWSSVKEHAKKLIEKFDIVAPGVDAPVKSLSGGNQQKLIVAREVSKNPELIVASQPTRGVDVASTEYIRNYLVKLRNENKAVLLVSADLDEVLQLSDRMAIMYEGQFVGIVKPEEVTEEQIGLMMGGIKDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJY8</accession>
    <name>F0LJY8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage SPO1 DNA polymerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466823.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00548"/>
    <dbReference type="EnsemblBacteria" id="ADT83525">
        <property type="protein sequence ID" value="ADT83525"/>
        <property type="gene ID" value="TERMP_00548"/>
    </dbReference>
    <dbReference type="GeneID" id="10040866"/>
    <dbReference type="KEGG" id="tba:TERMP_00548"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.549"/>
    <dbReference type="eggNOG" id="arCOG00905">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1029048_0_0_2"/>
    <dbReference type="OMA" id="PFANGWV"/>
    <dbReference type="OrthoDB" id="47739at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="104"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="247" mass="28861" checksum="0F1521771EE3C9A3" modified="2011-05-03" version="1">MLLEFERLKKIGGIYINPRNYKTMPLFLRDWRDLLSLDEKTYGIYAKTVYNPKERFLVKNEKDKQKAFKLAELYNELLKNPTKFCHKEYYEYQLKVKRFEGLPFANGWVGSKVVLVGEAPGRKGCGYTGICFYRDASGMLLRKALFSLGINPDFVYITNVVKCNPPENKLKGVDKRELSLLKKELEILRPKAIFALGRTAEKALKRVGFDAVYLRHPAWYVRRGLREPNDEMLEEYDVVRKSLNITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK05</accession>
    <name>F0LK05_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466840.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00565"/>
    <dbReference type="EnsemblBacteria" id="ADT83542">
        <property type="protein sequence ID" value="ADT83542"/>
        <property type="gene ID" value="TERMP_00565"/>
    </dbReference>
    <dbReference type="GeneID" id="26135893"/>
    <dbReference type="KEGG" id="tba:TERMP_00565"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.566"/>
    <dbReference type="eggNOG" id="arCOG02155">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2766309_0_0_2"/>
    <dbReference type="OMA" id="YGKQIYN"/>
    <dbReference type="OrthoDB" id="113119at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="69" mass="7684" checksum="E9C7672CDDCB1D15" modified="2011-05-03" version="1">MVMRLSKLYGKQIYNTKGYYVGYVDEVLIDIDRGHGKVLALGLPGEKVGIPYDRVTAIGDIILVKAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK11</accession>
    <name>F0LK11_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466846.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00571"/>
    <dbReference type="EnsemblBacteria" id="ADT83548">
        <property type="protein sequence ID" value="ADT83548"/>
        <property type="gene ID" value="TERMP_00571"/>
    </dbReference>
    <dbReference type="GeneID" id="26135887"/>
    <dbReference type="KEGG" id="tba:TERMP_00571"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.572"/>
    <dbReference type="eggNOG" id="arCOG07954">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187364_0_0_2"/>
    <dbReference type="OMA" id="GTIDFRW"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="73" mass="8513" checksum="52CFF119D77E7474" modified="2011-05-03" version="1">MENLRLIQKKLEVVKKHKELLMLEEAKLVRMMYQRKVGVSKKLAVVKREKAMALAQEAKLLRILKQNGQVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK35</accession>
    <name>F0LK35_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01772"/>
    <dbReference type="EnsemblBacteria" id="ADT84747">
        <property type="protein sequence ID" value="ADT84747"/>
        <property type="gene ID" value="TERMP_01772"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01772"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1771"/>
    <dbReference type="eggNOG" id="arCOG07855">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495791_0_0_2"/>
    <dbReference type="OMA" id="GGFYHYV"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="324"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="551" mass="62223" checksum="D69553C89214D2B7" modified="2011-05-03" version="1">MKMKKLMVLILIGFVVLSAGCTQKGTTPTETQEKPSETQITTSTPAQTQAQGINFKEYKRGEIIGNWWKLFDTSVIYVSKGYEDLAKHYFPNAQIKPASEFKSGIAILSPKDARELLRGKPMLITINNYFGYVVYKVGYKFVGQDIGMIVAYKEDNRDRLIFTGNGKAGAGATLKYALEIKEGKRKPKTTYILRRGDFEGVVLKEIGDNNWNGIPENGEYWTIDEIYFKEPFIYNWRIVNGENITVSGGFIRYVNGSRVYIYALSFNVSVEVKNGNGAKITYIVENVNPSIMKIPENAETGDTWIKFTTSEDHFAVQAKDLENFTFLAFGDHRPGSGRKVPEMFLKVRDAMNKDNGVFIIDGGDLVYSGKVDEWGELFKAWKFNKPVFIAVGNHEYQGEGVNVYHKYFGPTDYSFVLGNYYFIFMNNVEKGYSLSASQWKWLKNELEKAKKLNKKPIIVMHAPPIDPRPGGNHSMKESEGKKLLELMKEYNAFGIFSHIHIYWYGEKDGVSYVVTGGGGAPLYAKEGEGGFYHYVKISVDGGIHVEPIKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK49</accession>
    <name>F0LK49_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01786</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468057.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01786"/>
    <dbReference type="MEROPS" id="S26.017"/>
    <dbReference type="EnsemblBacteria" id="ADT84761">
        <property type="protein sequence ID" value="ADT84761"/>
        <property type="gene ID" value="TERMP_01786"/>
    </dbReference>
    <dbReference type="GeneID" id="10042102"/>
    <dbReference type="KEGG" id="tba:TERMP_01786"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1785"/>
    <dbReference type="eggNOG" id="arCOG01739">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089996_4_0_2"/>
    <dbReference type="OMA" id="FPKIGLI"/>
    <dbReference type="OrthoDB" id="106361at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027245">
        <property type="entry name" value="Sec11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="PTHR10806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="PTHR10806:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="157" mass="17717" checksum="389EEFF20080C4F2" modified="2011-05-03" version="1">MEEKIKSWKNDLVFIVISLIVIFAIHNGLKIALHTDSPLVIVVSGSMEPVFYRGDVVLLKGVKPEDIKIGDVVVYKRPYTKYPIIHRVREIEKIVLNGKEELCFVTWGDNNPAPDPYPYDGEILPCVPQEAVEAKALLVFPKIGLIPLEIRERLGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK81</accession>
    <name>F0LK81_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01818"/>
    <dbReference type="EnsemblBacteria" id="ADT84793">
        <property type="protein sequence ID" value="ADT84793"/>
        <property type="gene ID" value="TERMP_01818"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01818"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1817"/>
    <dbReference type="HOGENOM" id="CLU_2949484_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="59" mass="6704" checksum="D7BD7E2F6F2617EE" modified="2011-05-03" version="1">MKKITDNPGLLMGALLILFGILSMKWIIVWSGIFLFILAYILTEYSSQRERITGVGNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKE9</accession>
    <name>F0LKE9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466905.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00630"/>
    <dbReference type="EnsemblBacteria" id="ADT83607">
        <property type="protein sequence ID" value="ADT83607"/>
        <property type="gene ID" value="TERMP_00630"/>
    </dbReference>
    <dbReference type="GeneID" id="10040948"/>
    <dbReference type="KEGG" id="tba:TERMP_00630"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.632"/>
    <dbReference type="eggNOG" id="arCOG00557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_0_0_2"/>
    <dbReference type="OMA" id="YARTQSF"/>
    <dbReference type="OrthoDB" id="6553at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="24"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="234"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="925" mass="105773" checksum="E15C97AF8C427F15" modified="2011-05-03" version="1">MHILLRKAIEEKFGRLNELQLRAFSEISSGKSVLIIAPTGSGKTEAAVLPVLDAILKNGLKPISALYIAPIKALNRDLLERLEWWGAKTGIRVEVRHGDTSAYKKAKQTKNPPHLLIITPETLGVILTMKSLRAYLKNIKFVIVDEIAELVDNKRGVQLILGLERLSEIAEFQRIGLSATIGNEEEIKEWLKADVIVKPSLRKEYSVKVLFPSPDERDLKLAEKLKLPVDVATRLRVLWDIVEKHKRALIFTNTRQFAEILAHRLKAWGKPVEVHHGSLSKEARIQAERFLKEGKIKALICTSSMELGIDIGDVDVVVQYMSPRQVNRLIQRIGRARHRLGEVSRGYIITANVEDYLESLIIAQRAIEGKLERVKPYENALDVLAHFIVGLLIEYKHLPKDKPFEIAKRAYPYRNLKWEDYEGVLNILQEAHLIGCDEDKGILFLRRGAYAYYYENLSTIPDEISYRVFDVSSGHIIGRLDESFVMDLEEGTEFIMNGKSWILLGIDEEAKLLKVRESKSLESAIPSWEGEMIPVPLEVALDVGRLKRELLFDFERAKRIIKDVEFSEEELRKAKEILEMQEPLSTDRDVGIESLPKALVVHADFGNQVNEAIGRFVWSFLSMRYGKVFTMRAQAHAIVFKTPFQLNPSEVKSYLLQDGRALPFVISKSLRGSIIYRWRMLNVAKRIGALRREAKIRKIERLFEGTIIEKETLNELFHDKLDIENATEILDKIKSGIIRIKTTLNSEPSPLAEMNINIGGEFLISGELEKDEILELFKQRLLDTEVMLVCINCGWSSRTKVSRLRERLKYLECPKCSSRMIAVAHPIDAEEFLKAFKKLKQSKKLEKSEERAYRKLIKAADLVQSYGFDAVLALASYGTGPDTAARLLSQYRGEALLVALMEREREFIRTRRFWVDGRDGKVRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKF6</accession>
    <name>F0LKF6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0248 protein TERMP_00637</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0248 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466912.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00637"/>
    <dbReference type="EnsemblBacteria" id="ADT83614">
        <property type="protein sequence ID" value="ADT83614"/>
        <property type="gene ID" value="TERMP_00637"/>
    </dbReference>
    <dbReference type="GeneID" id="10040955"/>
    <dbReference type="KEGG" id="tba:TERMP_00637"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.639"/>
    <dbReference type="eggNOG" id="arCOG01302">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172276_3_1_2"/>
    <dbReference type="OMA" id="TQIPYHR"/>
    <dbReference type="OrthoDB" id="121890at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01245">
        <property type="entry name" value="UPF0248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007547">
        <property type="entry name" value="UPF0248"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MJ1316" evidence="2">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="87" mass="10264" checksum="8F37AEEF1E2772EC" modified="2011-05-03" version="1">MRKGSVKEALAKIKYDPRENESDYYIVIEHRGAYENIKKIPVEIIELGHGYFFIGETQIPYHRILAVVRKDGKIVWRKRGVSEELKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKK5</accession>
    <name>F0LKK5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA double-strand break repair Rad50 ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rad50</name>
        <name evidence="8" type="ordered locus">TERMP_01864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per homodimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01864"/>
    <dbReference type="EnsemblBacteria" id="ADT84839">
        <property type="protein sequence ID" value="ADT84839"/>
        <property type="gene ID" value="TERMP_01864"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01864"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1863"/>
    <dbReference type="eggNOG" id="arCOG00368">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004785_0_2_2"/>
    <dbReference type="OMA" id="FELPYSH"/>
    <dbReference type="OrthoDB" id="1771at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00449">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022982">
        <property type="entry name" value="Rad50_ATPase_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04423">
        <property type="entry name" value="Rad50_zn_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="7">
        <location>
            <begin position="398"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="168"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="368"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="465"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="25"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="769"/>
            <end position="774"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="865" mass="101143" checksum="9545499B6C2216CB" modified="2011-05-03" version="1">MKNFLSHKDTKIDFPLGVTVFIGPNGAGKTSIIDAIFVALFNTLPRGDKFDDIIYRGEREAKIELEFEEGGIPYKIVWRRKKGKSSPTYELYRLDKNMLIAHGVKAVKKEVENIIGIEKDSAVNSILIRQGEITSLLDQAPAKRKEIIGKLLGLEKLEKAWQFMREVIDHFEQIKNDLEKEIAEIGGELRSKSEQREKLKQEIQELKEKIKELEQILKKLEHQLGEIKRELDELNEKEKRYNELMIELAKKTEGIKSVQEQIKRLEKDLNESKEAKEKVKKLEEEIKKIPYLEKYIKCLNELKELNTEKEQLNADLSKILEIRNEANEKITVLCEKYGGNIEDSKEVGELPSDLAEIAKFVSRIFTWVESIVQQIEEKHKELEKLIIKALEVLPEATIEAKEKKLQELKEEKERLENEISRLQNEKGKLEGRINDLQQALSMLGESDTCPVCKTKLTPEHRDKVKSEMQEEIRGLKEEIRQKEKMLIEVSRQLLEVEKRIEQVSKVDIERIERLKKEIEEKKKELAEHYKELQRIITGLNDIENDIRSKISDIESKIKEIEEKLNELIKEIGHKLEDPENELKELRKKKEEYDRLKPIADKYEELLKDLKEKQEELEQLEREKCKLQEEIEKLGYDKKHHEEVRKKHEELLRQFERTKAELEEKNNSLKKKLEELNEVKEKIKELEEKLNNLEAELDKVKKFINDLERIRAAYHKDGVQKLLRKKFAPALSELATNYIESFNMDITDIYLSEDFDISVTKNSVEVPISLLSGGEKVAVALALRLAIARVLARRLSVIIMDEPTTHLDEERRRDLVEILGKFFKAENTVPQIIIVTHHRELEDVADTVYIVQKVDGISKVVESSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKM8</accession>
    <name>F0LKM8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetate--CoA ligase (ADP-forming)</fullName>
            <ecNumber evidence="2">6.2.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15081"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.2.1.13" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468158.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01887"/>
    <dbReference type="EnsemblBacteria" id="ADT84862">
        <property type="protein sequence ID" value="ADT84862"/>
        <property type="gene ID" value="TERMP_01887"/>
    </dbReference>
    <dbReference type="GeneID" id="10042203"/>
    <dbReference type="KEGG" id="tba:TERMP_01887"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1886"/>
    <dbReference type="eggNOG" id="arCOG01340">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007415_2_3_2"/>
    <dbReference type="OMA" id="CNFNPPE"/>
    <dbReference type="OrthoDB" id="15044at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="463" mass="50259" checksum="917DB1AB30720E9B" modified="2011-05-03" version="1">MNLEFLFYPRSVAVIGASHVPGKIGNAIMKSVARQFNGKIYAVNVKGGEIEINGQRFKVYRSILEIPDEVDVAVIAIPAKFVPDVIDECGQKGVKGAIVISAGFKEAGRADLEEELVKRARKWGIRIVGPNCLGVTNLENGFDCNFNPPERQARPKFGGIAFMSQSGAFGAAILDWAAKHNVGMSKFISLGNMADLDESDFMSYLKDDPKTKVITAYLEGVKDGRKFFKIARETTKAKPVIILKAGRTEAGAKAAASHTGSLAGSYAIYEAAFEQTGVLSAKSMRQLFNYAKALAMQKPAKGDRIAIVTNGGGAGVMMSDGLLEKGLKLAQLSDETNEKFAKAIEEGKLPHHMSYKNPIDVIGDAPSKRYELAMRYALEDPNVDVLVVIALFQSPALDEGIVDVMEKVQEYGKPIVFVAPGGEYPEKMARRIEEKGVPVFETVEDGVDAVYALVKYGKYLSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKN6</accession>
    <name>F0LKN6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">50S ribosomal subunit maturation GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01895"/>
    <dbReference type="EnsemblBacteria" id="ADT84870">
        <property type="protein sequence ID" value="ADT84870"/>
        <property type="gene ID" value="TERMP_01895"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01895"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1894"/>
    <dbReference type="eggNOG" id="arCOG00350">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_1_2_2"/>
    <dbReference type="OMA" id="EWQTGRF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="344" mass="39316" checksum="3A271D81C9201046" modified="2011-05-03" version="1">MIDEADIVIEVVDARDPIGTRNPKVERLVKESGKKLLIAMNKADLVPKEWAEEYKRKSDVPMVFISARERKGTGILRREIKKIAKELFDEGKEKVKVALIGYPNVGKSTIINVLKGKHAVGVAPIPGYTKGKQLIRLSKKIWLIDSPGVVPIDDFDELVIKGGFPADKIEDPVKPALKLIRRIIDTRKEALTEKYDIQEFESEEQILEAIGRKKGLLRKGGEVDIEETARYFLREWQTGKFTLFEKEEKREEEFQWAYSDVLEEIEQELLLDPRRILWKFREKIEPSNVKRVGIKEIEGFTVGIATGFKKCDSAKKLLEKITGKKVIASECFGKKWKGIIAILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKP1</accession>
    <name>F0LKP1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T2SSF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_01900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468171.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01900"/>
    <dbReference type="EnsemblBacteria" id="ADT84875">
        <property type="protein sequence ID" value="ADT84875"/>
        <property type="gene ID" value="TERMP_01900"/>
    </dbReference>
    <dbReference type="GeneID" id="10042216"/>
    <dbReference type="KEGG" id="tba:TERMP_01900"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1899"/>
    <dbReference type="eggNOG" id="arCOG01812">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_782166_0_0_2"/>
    <dbReference type="OMA" id="PYVLRHM"/>
    <dbReference type="OrthoDB" id="44971at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="185"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="353" mass="40270" checksum="8988E8D960774827" modified="2011-05-03" version="1">MGIGKKITDIFEKIGEKTLELSEKPIRRIPQGKSIQERLQVLKKMQEEVETERKEEREKEIEELVEWREKELQKPFSERIAEAVLKYFSGPVRSLTKSLKGLEYDLYRANIRMSKDKYVALMIGVSIISSIFTFLVGVLLMLPVDVSVLLALLGFIGGFLYMRNYPRIVWKHRVAEVERAMPYVLRHLASLLSAGVGIAEAILSVANSDYGVISEEFELIIRDMRGGASFEEALTRFEERMASENVSRVVKQMLRAVKFGGNLSGILYKLAEDFSFEYRMRLVEYVQKVNGLAFVYMFISVVMPTMLVVAVLAASIMNKRLIMPIQGLAVVLLFGFPAMAFLMVVMIKRSEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKS7</accession>
    <name>F0LKS7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polbeta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466954.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00679"/>
    <dbReference type="EnsemblBacteria" id="ADT83656">
        <property type="protein sequence ID" value="ADT83656"/>
        <property type="gene ID" value="TERMP_00679"/>
    </dbReference>
    <dbReference type="GeneID" id="10040997"/>
    <dbReference type="KEGG" id="tba:TERMP_00679"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.680"/>
    <dbReference type="eggNOG" id="arCOG02105">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1821106_0_0_2"/>
    <dbReference type="OrthoDB" id="136710at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="141" mass="16610" checksum="3F278D57E47DC695" modified="2011-05-03" version="1">MNEEIIEELKNFARDLEKLLGERLVAVIIFGSVLTSESFEDIDILVVVDNTSKDELKEIRRLKIKYRYKLGKYIDLNICEFSDLNKGVVYIAVAFGKEIYSTGKWKQKKEEIKKRAKERKLQFIEKHGKRVVRWELAELIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKS8</accession>
    <name>F0LKS8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466955.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00680"/>
    <dbReference type="EnsemblBacteria" id="ADT83657">
        <property type="protein sequence ID" value="ADT83657"/>
        <property type="gene ID" value="TERMP_00680"/>
    </dbReference>
    <dbReference type="GeneID" id="25394628"/>
    <dbReference type="KEGG" id="tba:TERMP_00680"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.681"/>
    <dbReference type="eggNOG" id="arCOG01191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123170_0_1_2"/>
    <dbReference type="OrthoDB" id="136452at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="9"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="127" mass="15128" checksum="18B717BB598C496B" modified="2011-05-03" version="1">MGVSRAYKLRLIQADIDLAKSAYEKGYYEMAIFHCQQAIEKSLKLLLEEKAGKYVRTHDLMFLRDLVGEFEEIRELLLDDEFLDRLEEGYFYGRYWDKPIEPFEDFEVQKAIYLAEEIFKRIKGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKT4</accession>
    <name>F0LKT4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbonic anhydrase family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466961.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00686"/>
    <dbReference type="EnsemblBacteria" id="ADT83663">
        <property type="protein sequence ID" value="ADT83663"/>
        <property type="gene ID" value="TERMP_00686"/>
    </dbReference>
    <dbReference type="GeneID" id="10041004"/>
    <dbReference type="KEGG" id="tba:TERMP_00686"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.687"/>
    <dbReference type="eggNOG" id="arCOG01849">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064827_4_1_2"/>
    <dbReference type="OMA" id="YVTIGHN"/>
    <dbReference type="OrthoDB" id="84330at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="174" mass="18898" checksum="1E73B1CEEC248CF2" modified="2011-05-03" version="1">MAIYEFEGKKPKIHESAFVDENAVIIGDVVLEEKTSVWPSAVLRGDIEQIYVGKGSNIQDNVSIHTSHGQPTIIGEYVTIGHNAVVHGARIGNYVIIGMGAIVLDGAKIGNHVIVGAGALIPPGKEIPDYSLVIGVPGKVVRQLSEKEIEMTKRNAEIYIELAEKHLRGRRKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKV1</accession>
    <name>F0LKV1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466978.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00703"/>
    <dbReference type="EnsemblBacteria" id="ADT83680">
        <property type="protein sequence ID" value="ADT83680"/>
        <property type="gene ID" value="TERMP_00703"/>
    </dbReference>
    <dbReference type="GeneID" id="26136106"/>
    <dbReference type="KEGG" id="tba:TERMP_00703"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.704"/>
    <dbReference type="eggNOG" id="arCOG00352">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011784_0_0_2"/>
    <dbReference type="OMA" id="DPSEYCG"/>
    <dbReference type="OrthoDB" id="66209at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="168"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="346" mass="40009" checksum="2FDE5AB32980E62D" modified="2011-05-03" version="1">MKNPFEKMPTILLADELIDKAFRRAEKAASSFTPRGNKISKARQREELRIRTVSNVIRDNLRKILDRTPGVSTLPPFYQELVDTLVDRKMFHKALASVNWAIKTIRTLEERYVEKVRYSRDPNEIAQLRRQFYGRVASVIKDIADNLEYLNKARDVLKDLPVIDLSLPTIVIAGHPNVGKSTLLRQLTNAKPEVASYPFTTKGINVGQFEEHWLKYQVIDTPGLLDRPLSERNEIERQAILALKHLGKVIIYIFDPSEYCGFPLEEQMHLFEEIYEEFKEFPFIVVLNKVDVADEEKIRKAEEFLRAKGIEPIRIVAKEGLGVDEVKKKILEILKPELEEEISRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKV7</accession>
    <name>F0LKV7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0212 protein TERMP_00709</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0212 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466984.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00709"/>
    <dbReference type="EnsemblBacteria" id="ADT83686">
        <property type="protein sequence ID" value="ADT83686"/>
        <property type="gene ID" value="TERMP_00709"/>
    </dbReference>
    <dbReference type="GeneID" id="10041027"/>
    <dbReference type="KEGG" id="tba:TERMP_00709"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.711"/>
    <dbReference type="eggNOG" id="arCOG02119">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138334_0_0_2"/>
    <dbReference type="OMA" id="KVFNAQS"/>
    <dbReference type="OrthoDB" id="101789at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01223">
        <property type="entry name" value="UPF0212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007564">
        <property type="entry name" value="UPF0212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42199">
        <property type="entry name" value="PTHR42199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04475">
        <property type="entry name" value="DUF555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016934">
        <property type="entry name" value="UCP016934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="129" mass="14058" checksum="708E98BD0AE2816F" modified="2011-05-03" version="1">MGDYIVVLEAPIIVRDVETPEDAINVAVSKVAKALNKEKLDFVKVEIGYSQCPVCGSPFESAFVIGSIGLVGIYLTLKVFNAQSLEHAERIAKAVVGKALKRVPLKVFEIKEIHNGKEGEGFHFDEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKW7</accession>
    <name>F0LKW7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum cofactor biosynthesis MoaB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466994.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00719"/>
    <dbReference type="EnsemblBacteria" id="ADT83696">
        <property type="protein sequence ID" value="ADT83696"/>
        <property type="gene ID" value="TERMP_00719"/>
    </dbReference>
    <dbReference type="GeneID" id="10041037"/>
    <dbReference type="KEGG" id="tba:TERMP_00719"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.721"/>
    <dbReference type="eggNOG" id="arCOG00214">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077358_2_3_2"/>
    <dbReference type="OMA" id="TGWDGIL"/>
    <dbReference type="OrthoDB" id="108340at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012245">
        <property type="entry name" value="MoaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43232">
        <property type="entry name" value="PTHR43232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006443">
        <property type="entry name" value="MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="169" mass="18774" checksum="163D490D696449F4" modified="2011-05-03" version="1">MSHEEHRAKAPKKFKFAVITVSDTASVGKREDLSGYYIIEELKKVGNENVYYKIVPDEKLAILKAVLEALDKADVVITTGGTGVTRRDVTIETIKPLFDKELVGFGEIFRLKSFEEIGTAAVLTRATAGIIRDKESKVVFCLPGSLNAVKIGVEIIKREAYHILKHARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKY5</accession>
    <name>F0LKY5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyrrolidone-carboxylate peptidase</fullName>
            <ecNumber evidence="9">3.4.19.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">5-oxoprolyl-peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyroglutamyl-peptidase I</fullName>
            <shortName evidence="9">PGP-I</shortName>
            <shortName evidence="9">Pyrase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pcp</name>
        <name evidence="12" type="ordered locus">TERMP_01917</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Removes 5-oxoproline from various penultimate amino acid residues except L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.</text>
            <dbReference type="EC" id="3.4.19.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.3" evidence="9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468188.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01917"/>
    <dbReference type="MEROPS" id="C15.001"/>
    <dbReference type="EnsemblBacteria" id="ADT84892">
        <property type="protein sequence ID" value="ADT84892"/>
        <property type="gene ID" value="TERMP_01917"/>
    </dbReference>
    <dbReference type="GeneID" id="10042233"/>
    <dbReference type="KEGG" id="tba:TERMP_01917"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1916"/>
    <dbReference type="eggNOG" id="arCOG05850">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043960_4_3_2"/>
    <dbReference type="OMA" id="KLAYNHK"/>
    <dbReference type="OrthoDB" id="97570at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00417">
        <property type="entry name" value="Pyrrolid_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029762">
        <property type="entry name" value="PGP-I_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033694">
        <property type="entry name" value="PGPEP1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033693">
        <property type="entry name" value="PGPEP1_Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PTHR23402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00504">
        <property type="entry name" value="pyro_pdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01334">
        <property type="entry name" value="PYRASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01333">
        <property type="entry name" value="PYRASE_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="9 10">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="9 11">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT84892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="199" mass="22026" checksum="320337DBBD6240A5" modified="2011-05-03" version="1">MKVLVTGFEPFGGENVNPSWEAVKMLPDAIRDAEIVKYQLPVSFKKVKELLPDIISKEKPGVIILTGQAGGRVNVTVERVAINVMDSKKEDNDGYKPEDEPIFEDAPAAYFSTLPIKRIVKALRENKIPAVVSNTAGTYVCNTAMFTALHYVATNELKAKAGFIHVPYIPEQVLEKNAPSMPLEMIKRAIEIAIRESLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKZ0</accession>
    <name>F0LKZ0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyruvate-formate lyase-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01922</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01922"/>
    <dbReference type="EnsemblBacteria" id="ADT84897">
        <property type="protein sequence ID" value="ADT84897"/>
        <property type="gene ID" value="TERMP_01922"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01922"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1921"/>
    <dbReference type="eggNOG" id="arCOG00947">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044176_1_0_2"/>
    <dbReference type="OMA" id="RPMEIKP"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="67"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="339" mass="38966" checksum="B97CECFB0198AE2A" modified="2011-05-03" version="1">MMKVEELYQKEGNKIRCLICERQCIIAEGKRGVCKNYANLNGKLIHLSYGKLSAVESRPIEIKPFFHYYPNSTALTFSGFGCNFYCPWCQNYHLSFSEPPRELRIISPKELVDLALKHGDEGLCASFNEPATLYTYLLDVFELGKKRGLYGCLVTNGYFTIKALERLIESGVSGFSIDIKGCPGIKVLTTVDHKKVFRNAKRALDLNVHVEMVYLVVTNANDFEECYSWIFKMHSEMLGENVPLHINRYYPMNYWREKPTSAKTLLDLKEIAQKEYNISYVYLGNIGSIEHETTYCPKCGKKLIVRSAYRVVEWNLTKDNRCPRCGEKIPIYGKANISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL03</accession>
    <name>F0LL03_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PS_pyruv_trans domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468206.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01935"/>
    <dbReference type="EnsemblBacteria" id="ADT84910">
        <property type="protein sequence ID" value="ADT84910"/>
        <property type="gene ID" value="TERMP_01935"/>
    </dbReference>
    <dbReference type="GeneID" id="10042251"/>
    <dbReference type="KEGG" id="tba:TERMP_01935"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1934"/>
    <dbReference type="eggNOG" id="arCOG00397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070992_0_0_2"/>
    <dbReference type="OMA" id="DYESPTH"/>
    <dbReference type="OrthoDB" id="31624at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="13"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="360" mass="41471" checksum="FBE10CFAA50091B6" modified="2011-05-03" version="1">MVSALLLKTWMINIGNEIIENGAKAAIKRAVPDLKLFETSGYSYHLVYSKFRYSLTSSLLNKLGFKRDINKEWHKNLVSSAYLIHNKSIDFAVFPGCILDKFTLPRYYPILLKLMSKGIPIILLGAGGHDYTKATVDYVSKILKKLKPLALITRDSVAYEYYSQISEIKYVYNGIDCGFFINDWYQPPQADKKFIVLAFDKASKVPPHVLDRIKSIDSDVTVIFTTHRPFNYLYYTIPADVFARLPIAISRFLLARRELLKSDRNLLNKENVFISDNVKDYLFLYSNAVEVHSDRVHAVVSSLAYDTRAWLYYSTPRALLFENVGAKINENLIVMNKKVLTTKKKELVTFLREIIEDNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL20</accession>
    <name>F0LL20_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TrmB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468223.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01952"/>
    <dbReference type="EnsemblBacteria" id="ADT84927">
        <property type="protein sequence ID" value="ADT84927"/>
        <property type="gene ID" value="TERMP_01952"/>
    </dbReference>
    <dbReference type="GeneID" id="26137497"/>
    <dbReference type="KEGG" id="tba:TERMP_01952"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1951"/>
    <dbReference type="eggNOG" id="arCOG05817">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186537_0_0_2"/>
    <dbReference type="OMA" id="EKANIMV"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="69" mass="8061" checksum="9CE9458E6D806DB0" modified="2011-05-03" version="1">MRRREYIYKLLVVKKRAVTLQKLSEELETPMPKLLQTLKSLESDGLVEVFYGKEKAAIMVKAKTLDDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL32</accession>
    <name>F0LL32_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468235.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01965"/>
    <dbReference type="EnsemblBacteria" id="ADT84939">
        <property type="protein sequence ID" value="ADT84939"/>
        <property type="gene ID" value="TERMP_01965"/>
    </dbReference>
    <dbReference type="GeneID" id="10042280"/>
    <dbReference type="KEGG" id="tba:TERMP_01965"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1963"/>
    <dbReference type="eggNOG" id="arCOG05777">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181235_0_0_2"/>
    <dbReference type="OMA" id="WRAFING"/>
    <dbReference type="OrthoDB" id="113312at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021583">
        <property type="entry name" value="DUF3213"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11491">
        <property type="entry name" value="DUF3213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="98" mass="11500" checksum="8E5F082753A72FEC" modified="2011-05-03" version="1">MERKLKFVELKFGRITPQEAMDLQYKLSVNPATYRVFINGYSKRGMIIFDEEKLPKEKLLEMLSELNPQIIEEKEISIEELVNSSMSWKNVMGEVLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL38</accession>
    <name>F0LL38_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468241.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01971"/>
    <dbReference type="EnsemblBacteria" id="ADT84945">
        <property type="protein sequence ID" value="ADT84945"/>
        <property type="gene ID" value="TERMP_01971"/>
    </dbReference>
    <dbReference type="GeneID" id="10042286"/>
    <dbReference type="KEGG" id="tba:TERMP_01971"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1969"/>
    <dbReference type="eggNOG" id="arCOG01407">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045353_0_0_2"/>
    <dbReference type="OMA" id="FDPWKDL"/>
    <dbReference type="OrthoDB" id="83551at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="220"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="413" mass="47927" checksum="6DEAFB614F5CBDF1" modified="2011-05-03" version="1">MFEVKNFGGKGKNLRNYEVIIGSEEIEKIMEKAESLKGKTIVNVNSTAFGGGVAEILHNLIPLMRSLGIDARWFVIEGTDEFFKVTKTFHNALQGNKELKLTEEMEQLYLEINKRNSENFDPSLYDFVVIHDPQPAPLISFYDKRQPWIWRCHIDLSDPNPEFWGFLRQFVEKYDRYIFHMPEYAQSDLDKDRVIIMPPSIDPLSEKNIELKESEILKILEKFDVDPDRPKITQVARFDPWKGVFDVIEVYRKVKEKIPDVQLLLVSAMAHDDPEGWIYFEKVLRKIGEDYDVKILTNLIGVHAKEVNAFQRASDVVLQMSTREGFGLTVSEAMWKEKPVIGRAVGGIKLQVVDGETGFLIRTVDEAVEKTLYLLKHPEVAKRMGQKAKERVRENFIITKHLERYLDLFTLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL93</accession>
    <name>F0LL93_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467042.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00767"/>
    <dbReference type="EnsemblBacteria" id="ADT83744">
        <property type="protein sequence ID" value="ADT83744"/>
        <property type="gene ID" value="TERMP_00767"/>
    </dbReference>
    <dbReference type="GeneID" id="10041085"/>
    <dbReference type="KEGG" id="tba:TERMP_00767"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.769"/>
    <dbReference type="eggNOG" id="arCOG03524">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_616272_0_0_2"/>
    <dbReference type="OMA" id="VLEQNYE"/>
    <dbReference type="OrthoDB" id="66041at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="435" mass="49271" checksum="38C08C401D1B8839" modified="2011-05-03" version="1">MKKKILGGIFVAFLLLAMIVLHQTRAADESGTLVLYDSARIGVVEKTITLDLKKGFNEVPLAEIEGLNIEEITLKPLSDKVMVLGINSQAYPTKGVFEANIGKTVTIKLKGGETITGKFLGYKDGKIAVQGDSYYLIEPEEVAYMKITELGSKAKTQTYAIIQAEEDGKYKFKLIYRVQSIGWSSRYKLYLTNKALLFGYIVIDNPTNKTFEDFKVMLVSGEVNFYAPPQVVMEKVYATAEKAAAGIPEQPQKIEAFYLYNLGMLSVNSFEKKMIPYITQETSFEREYLYESYPYGGSNEIYEIISFKAEKVLPAGIVEIYKEMNDTTVLIGEQKIDHTAKGDTLRLKLGRDVDLKGKTEILEQRRESDSTYYKVRITIENFGNRTKEVVVRHYKWSGKILSSTVEPIDDTAHYVEFKITVKPGEKKEIVFDYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLC0</accession>
    <name>F0LLC0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TsaA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467069.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00794"/>
    <dbReference type="EnsemblBacteria" id="ADT83771">
        <property type="protein sequence ID" value="ADT83771"/>
        <property type="gene ID" value="TERMP_00794"/>
    </dbReference>
    <dbReference type="GeneID" id="10041112"/>
    <dbReference type="KEGG" id="tba:TERMP_00794"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.796"/>
    <dbReference type="eggNOG" id="arCOG00761">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1264617_0_0_2"/>
    <dbReference type="OMA" id="FVERYDC"/>
    <dbReference type="OrthoDB" id="117039at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023368">
        <property type="entry name" value="UPF0066_cons_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818">
        <property type="entry name" value="PTHR12818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="SSF118196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00104">
        <property type="entry name" value="tRNA_TsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01318">
        <property type="entry name" value="TSAA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="214" mass="24626" checksum="E2EDC06CC2D6CC9D" modified="2011-05-03" version="1">MEKFKIIPVGVVRKDAGEDILEIFPRFRDAADGLHEGDFIKLILWFHKSDTLEKRRVLKVHPHGNPQNPLTGVFATRSPVRPNPLAIYTVRIHRIEEGRIYIDPIDAENGTPIADIKIFVESLDCPARRELEEWELDIENARQIGKLNLIPRISEHLDELEEVSPEEFTALIVELGSRTIYLTAKDLADLIRFLNETYERLPVEIKDKLKSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLE6</accession>
    <name>F0LLE6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase</fullName>
            <ecNumber evidence="2">2.7.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_02001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15669"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13184"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136416"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.78"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end dephospho-ribonucleoside-RNA + ATP = a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54580"/>
            <dbReference type="Rhea" id="RHEA-COMP:13935"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.78"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.1.78" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468271.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02001"/>
    <dbReference type="EnsemblBacteria" id="ADT84975">
        <property type="protein sequence ID" value="ADT84975"/>
        <property type="gene ID" value="TERMP_02001"/>
    </dbReference>
    <dbReference type="GeneID" id="10042316"/>
    <dbReference type="KEGG" id="tba:TERMP_02001"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1998"/>
    <dbReference type="eggNOG" id="arCOG04127">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051301_0_1_2"/>
    <dbReference type="OMA" id="RKIHREM"/>
    <dbReference type="OrthoDB" id="90701at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="PTHR12755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="26"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="356" mass="40668" checksum="E1060572BE19C7F9" modified="2011-05-03" version="1">MNKARYTQEVPEDRKELLNALNEHKKPVKIMILGGVDTGKTTLATFLANELLSSGFRIAIIDSDIGQKGILPPATISLGFPEGLFESFGEIKAYKHYFVGSITPNQFFGEMIAGVKLLTDEAEKKADIIIIDTTGMISGAGVELKRMKIETVKPDVIVALQKENELEPILKPFEEKTQIFRLEVSKKVRKFSREERREIRKEKWKKYFRDSKSYTVNLNHFIISGTQLFQGEDINENEKSLLEALFKWLIIHGRKIGGKYLIVKVDTSNIPRQVDKNVLQYIDFEKLSNLLLGMIDKDGFCVGLGILKFVNFRDMKAEILTPLDEETIKEIREIRFGRVRVREDGEELGLLDRNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLG6</accession>
    <name>F0LLG6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin-like protein CetZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cetZ</name>
        <name evidence="7" type="ordered locus">TERMP_02021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in cell shape control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CetZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468291.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02021"/>
    <dbReference type="EnsemblBacteria" id="ADT84995">
        <property type="protein sequence ID" value="ADT84995"/>
        <property type="gene ID" value="TERMP_02021"/>
    </dbReference>
    <dbReference type="GeneID" id="10042336"/>
    <dbReference type="KEGG" id="tba:TERMP_02021"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2018"/>
    <dbReference type="eggNOG" id="arCOG02202">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058152_0_0_2"/>
    <dbReference type="OMA" id="TNVPRIK"/>
    <dbReference type="OrthoDB" id="23481at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01946">
        <property type="entry name" value="CetZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032907">
        <property type="entry name" value="CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="2"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="10"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="103"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="364" mass="39889" checksum="F5DE881E66934646" modified="2011-05-03" version="1">MRALIIGIGQCGTKIADLFALVDFEAIAINTSKSDLEYLKHIPQERRILIGESLTGGKGVNANPVLGREAMKRDLSLVMRKMNSVIGYEDVDIFFLTFGFGGGTGAGGTPVLAEALKEEYPDSLVVAIGALPLKEEGIRPTINAAITIDKLSKFADSIIAIDNNKLKETGMDISGAYEKINYTIVERIASLLALIDVPGEQTLDASDLKFVLKAFGSFATVGYAKAEANKVKNLSRLILKSFENEGLYLDANIESALYGLVAIHGPPELLKANEIFEALDYLAQKIKGKQIFRGFYPDPREREVEVVTLLSGIYESKSIEDIILTAKRYAQSFIKAKEEAEVRKRELLSGLPDFDDLYPGEINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLR9</accession>
    <name>F0LLR9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetyl-D-mannosamine dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.336</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-ManNAc 6-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_00869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate</text>
            <dbReference type="Rhea" id="RHEA:25780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:68623"/>
            <dbReference type="ChEBI" id="CHEBI:70731"/>
            <dbReference type="EC" id="1.1.1.336"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.336" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467144.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00869"/>
    <dbReference type="EnsemblBacteria" id="ADT83846">
        <property type="protein sequence ID" value="ADT83846"/>
        <property type="gene ID" value="TERMP_00869"/>
    </dbReference>
    <dbReference type="GeneID" id="10041187"/>
    <dbReference type="KEGG" id="tba:TERMP_00869"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.872"/>
    <dbReference type="eggNOG" id="arCOG00252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_2_2"/>
    <dbReference type="OMA" id="IELANTH"/>
    <dbReference type="OrthoDB" id="41144at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089714">
        <property type="term" value="F:UDP-N-acetyl-D-mannosamine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="9">
        <location>
            <begin position="322"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="428" mass="47984" checksum="4E040251DC3D2345" modified="2011-05-03" version="1">MRERIQNRNVEIAVIGLGYIGLPTAIMFANSGFNVTGYEIREEVVKKLNSGTAHIVEPEINKLLQEAIKSGKLRATSNPEDIKNKDVYIICVQTPLREDKTPNLEYLESAVKTVARAMKKGSMVIIESTVPPLTTVRMARLIETLTGLKAGEDFYMVHAPERVMPGRIFKELVYNSRILGGITRESADLAEILYRTFVKGQIFKTDPTTSEMVKLMENTFRDVNIALANEFAFLAHQYGINIFEAIELANTHPRVKIHIPGIGVGGHCLPKDPYLLLSSAKEDFGLIKKAREINEDMPLMAKDLLFEAFKMINLPPEEAVVTVLGLAYKGNSDDTRNSPAYVFIEAIQDDVKEVRSYDPYVSGTHETLEEAVKDSDAIVIATDHSQFKKLNWEELGKLMRNKILIDGRHVIDKPPKGFIFKGIGRGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLS2</accession>
    <name>F0LLS2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoate--protein ligase</fullName>
            <ecNumber evidence="4">6.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_00872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467147.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00872"/>
    <dbReference type="EnsemblBacteria" id="ADT83849">
        <property type="protein sequence ID" value="ADT83849"/>
        <property type="gene ID" value="TERMP_00872"/>
    </dbReference>
    <dbReference type="GeneID" id="10041190"/>
    <dbReference type="KEGG" id="tba:TERMP_00872"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.875"/>
    <dbReference type="eggNOG" id="arCOG03837">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181210_0_0_2"/>
    <dbReference type="OMA" id="PYINVED"/>
    <dbReference type="OrthoDB" id="129723at2157"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016979">
        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019491">
        <property type="entry name" value="Lipoate_protein_ligase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10437">
        <property type="entry name" value="Lip_prot_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lip_prot_lig_C" evidence="8">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="94" mass="11101" checksum="7FC834EDB19926C7" modified="2011-05-03" version="1">MKKIGEHKARKGLIRFEIEEKDGIAENVKITGDFFIYPENTIEELEKKLKGHKLEELEHIIDEFFAMRLDVEMPYINVEDFKIALKNALRGEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLS3</accession>
    <name>F0LLS3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="8">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">argS</name>
        <name evidence="13" type="ordered locus">TERMP_00873</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467148.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00873"/>
    <dbReference type="EnsemblBacteria" id="ADT83850">
        <property type="protein sequence ID" value="ADT83850"/>
        <property type="gene ID" value="TERMP_00873"/>
    </dbReference>
    <dbReference type="GeneID" id="10041191"/>
    <dbReference type="KEGG" id="tba:TERMP_00873"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.876"/>
    <dbReference type="eggNOG" id="arCOG00487">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_1_2"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="OrthoDB" id="7046at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="12"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="525"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT83850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="647" mass="74842" checksum="ED8733EAAEDD102E" modified="2011-05-03" version="1">MAYDDIKEEVKLILKEIISDMLEKEGKSWDGEILFDETPSMELGDFATTVAFQLAKVFRKAPRIIAQEIVEKTKNKLPEYISKVEVAGAGYINFFLDYEKFGKLIIEEILTKGEKYGKSNIGKGKKVVIEHTSVNPTKPLHMGHARNSILGDTMARVMRTLGYNVEVQNYIDDLGIQFAQVMWGYLNLKEEFEKIKAEIEERCIKENSIDHVLGLLYVEVHRKMEENPEVEKEVRELMKKLEEGDNEIAELGRRLAEEVVKAQMQTTYRLNIAYDLLSWESDIVRSGIFEEAYRKIEQNEHFEWAKEGKYKGAFIMKLGDLFPDMENPDMVLIRSDGTATYTGKDIAYHMWKFGLVSADMLYKIWDRIMFEKKEHETWTTARDGKPMPGKFGHADIVINVIGAEQRYPQKVVAYALKLLGYEEAYRNFHHLAYEHVVRPEGKFSGRKGTWIGFTVDEVVNEAVKRAKELVEEKNPNLSEEEKKKIAEAVGIGAIRYNMLKYSPEKIITFRWEDVLNFEGESAPYIQYAHARCASILRKAMEKGIDLRFNNLLENADFSNLDRKEKDLIKLLSRFPEIVKEVGTEIKPHLLAWYANEVAMVFNKFYMALPVLKAERGTLEERLLLVMATKQVLRNVLYLMGIEAPERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLS4</accession>
    <name>F0LLS4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467149.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83851">
        <property type="protein sequence ID" value="ADT83851"/>
        <property type="gene ID" value="TERMP_00874"/>
    </dbReference>
    <dbReference type="GeneID" id="10041192"/>
    <dbReference type="KEGG" id="tba:TERMP_00874"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.877"/>
    <dbReference type="HOGENOM" id="CLU_2056179_0_0_2"/>
    <dbReference type="OrthoDB" id="136143at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="145" mass="16082" checksum="42B5B71E38AD1B8C" modified="2011-05-03" version="1">MRKLFGSGLIIGGTLYLVFLLTMYPHLVGGYGGGEQMILTHSNQFTDALYLNGDISVKLTSDTPFTVKIDGERVGEFKMYSARFKGEHLIEVESNQECIVYVELRQHPSIIKYAISLVLIGAGSLILVSEKEEQKIEVNTGKPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLT3</accession>
    <name>F0LLT3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_00883</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00883"/>
    <dbReference type="EnsemblBacteria" id="ADT83860">
        <property type="protein sequence ID" value="ADT83860"/>
        <property type="gene ID" value="TERMP_00883"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00883"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.886"/>
    <dbReference type="eggNOG" id="arCOG05830">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_377966_0_0_2"/>
    <dbReference type="OMA" id="FAVHPPL"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="67"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="765" mass="88987" checksum="08CE8A515DBD64B6" modified="2011-05-03" version="1">MWKRKVKSIDKKVLAFIMIFLYYFVTRLYGISGHMNEYFDYDEGTYLMIARLINQGYLPYRDIFAVHPPLFYYMLALWLRIFGDNYVVGRLFSVFLGFLSLIIAYCIGKEVKSWELGVTFTGLLAMDPLLIHVNPLVFHESSIEFFTLLSLYYFVRFVKTENLKYAYISLFWAGLGSTSKFTILPFAVALYLTIFFSLNQEIFEHAKNASKVLLNKKQVFICLVSYILITIISMSTIFMWPSELVRKLMIVPGLHKIEVYGQIIPSAFLLAIWGILTIYVFRISYVDKLIRFAIFSIKNIRSAILLALAFLLPKLIIEGILGVMISRDYIYQTYLAQGGRGFPIINLFMYIGDKFGHIYNNTLELMIANVPLILLVAVILLVWTLDLSSEPNPVSQHLRVLFIVSFFMYFFVSPTLPNDRFLISLWLVLYLLLLEFLSSVKFTKKQLYGMLSIFIVFLLIADYGMVYQYPQGKLKFIWAVHSKEMRDELKEYILKNNLSNEKFYAVNPMNTYYLGLQTEPYYIDTFGLILLKDTNTTEILSALSRRDVKYYILSTWIYYKWPEPANKEFNNLISYINKNGYLLYGDSYKNGDIIEIYKLKEFPRWNNSEIALFSYTGAILIENHSEYIAKIYATRNNKHYNLRTKIKISSINPLIYDVTQYSTDTQVKFSLSIASDSLKFVLPSDSELIMEFYAPVTVGYSLTSNPNVEKILTKNHSVHATKVNIYYKDYILSLSGDNIKLTKISEDTVEIIGNNITIKITRERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLY0</accession>
    <name>F0LLY0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02105"/>
    <dbReference type="EnsemblBacteria" id="ADT85079">
        <property type="protein sequence ID" value="ADT85079"/>
        <property type="gene ID" value="TERMP_02105"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02105"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2102"/>
    <dbReference type="eggNOG" id="arCOG04502">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136715_2_0_2"/>
    <dbReference type="OMA" id="SFAIMER"/>
    <dbReference type="OrthoDB" id="97120at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18680">
        <property type="entry name" value="PIN_MtVapC20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039018">
        <property type="entry name" value="VapC20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42188">
        <property type="entry name" value="PTHR42188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="143" mass="16382" checksum="F99AC62BF5FDD291" modified="2011-05-03" version="1">MDTGTLIAFFDKGDKNHEIAVSYFESSVLKGAKFVVGRPVLVEFLNGASKVNGKRVAIQLKNLICSSKYILIEDETEEDWEKAWRLFEKFKDQDGMDLVDCLSFAIMERLEITKAFTFDSDFATYGFTVVPRPPKPKKKQKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLY1</accession>
    <name>F0LLY1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468376.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02106"/>
    <dbReference type="EnsemblBacteria" id="ADT85080">
        <property type="protein sequence ID" value="ADT85080"/>
        <property type="gene ID" value="TERMP_02106"/>
    </dbReference>
    <dbReference type="GeneID" id="10042421"/>
    <dbReference type="KEGG" id="tba:TERMP_02106"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2103"/>
    <dbReference type="eggNOG" id="arCOG07098">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2534851_0_0_2"/>
    <dbReference type="OMA" id="SEREDWG"/>
    <dbReference type="OrthoDB" id="116067at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="83" mass="9465" checksum="14E9FF8C99BD42B3" modified="2011-05-03" version="1">MKVVQTEIDLETYNVLKAIAIHRGVSLKEVIRESLRDYADAHKKDLVKNIYDDPIWKGIGLLHTGDPEASEKDTWGVVEWSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLZ4</accession>
    <name>F0LLZ4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polysacc_synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_02119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468389.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02119"/>
    <dbReference type="EnsemblBacteria" id="ADT85093">
        <property type="protein sequence ID" value="ADT85093"/>
        <property type="gene ID" value="TERMP_02119"/>
    </dbReference>
    <dbReference type="GeneID" id="10042434"/>
    <dbReference type="KEGG" id="tba:TERMP_02119"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2116"/>
    <dbReference type="eggNOG" id="arCOG02209">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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            <end position="32"/>
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            <begin position="126"/>
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        </location>
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        </location>
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        </location>
    </feature>
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            <end position="388"/>
        </location>
    </feature>
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            <end position="416"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT85093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="488" mass="54293" checksum="725B98B61F1E49A8" modified="2011-05-03" version="1">MKDELKKITAGSKLVLVGTLVWITLEFLSRVIIGRHFSSEEYGIYNLTLSIFTLSLLLATLGFQSGVPREISYYSEKSPSKVDKLISTALIIIMATSVLVSLVLVINAENIAGIFKNERLISPLRVISLALPFSALSVTITAISRGFGRVKEQICFQNIFYPTILLILIVVVILRQYPFNYVFWAYVGANYLTFLALFILIWKIKLVKIGLLFDSKLGKELLLFSIPLLLSSILGFVMTWIDTLMIGYYLSATSVGVYNAAAPIAKLLPVILNSVAFLYVPVASKLYAQNRVNDLAKIYQSLTRLVFFFTFPVFVIVLLYPETILGYVFGSKYITATPALRILAVGFIVHVLFGLNGMSLVIIGKTTLNLVGELTAVLVNVILNILLIPKYYLIGAAIATTFSYILANLVRSFWLYRLLKIHPFTREYIRQITVSVLTLAVAYLLSVGLFEKSLGFQLIGGVSTFVMYFGIILLSGSVSLKELKVLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLZ5</accession>
    <name>F0LLZ5_THEBM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
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    <dbReference type="STRING" id="391623.TERMP_02120"/>
    <dbReference type="EnsemblBacteria" id="ADT85094">
        <property type="protein sequence ID" value="ADT85094"/>
        <property type="gene ID" value="TERMP_02120"/>
    </dbReference>
    <dbReference type="GeneID" id="10042435"/>
    <dbReference type="KEGG" id="tba:TERMP_02120"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2117"/>
    <dbReference type="eggNOG" id="arCOG04525">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="DASEQFP"/>
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    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="332" mass="39478" checksum="49E3B6D00440C7DB" modified="2011-05-03" version="1">MLGSKKYSWVNLIIHRFKEYTLKGIVELTQKNNGDSIFEDDWRNLIILDDCRYDIFKSEYIKRRLPGRLEYKISKGSWTGEFLLKNFTDKKYDDIIYITANPFVDKYLKGKFYKVISVWKNGWNERYNTVPPNKVYEQTIKTLKKYPNKRFVVHFLQPHHPYFSLQNFEDNAMNIIKNSVEKNHSMSLSGFPKEPLHSIYLSEIYAYFSLSKLIRAYIENLRIVLPYVELLLHYLPGRTIITSDHGEIFGKPVTKLLPIKVYGHGIGRIPDLVKVPWLIFEEEDKPKLRPIKDIKKDIARIEKRYMLHESSKQKELKKIKRAISQLKLKQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLZ6</accession>
    <name>F0LLZ6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-phosphooligosaccharide-protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Oligosaccharyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">TERMP_02121</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.21" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468391.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02121"/>
    <dbReference type="EnsemblBacteria" id="ADT85095">
        <property type="protein sequence ID" value="ADT85095"/>
        <property type="gene ID" value="TERMP_02121"/>
    </dbReference>
    <dbReference type="GeneID" id="10042436"/>
    <dbReference type="KEGG" id="tba:TERMP_02121"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2118"/>
    <dbReference type="eggNOG" id="arCOG02044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355503_0_0_2"/>
    <dbReference type="OMA" id="TTARDYW"/>
    <dbReference type="OrthoDB" id="45041at2157"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="PTHR13872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADT85095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="658" mass="75130" checksum="891793033DD15B66" modified="2011-05-03" version="1">MGNPKILSNYKVHFPLLILTVALGYRIYPYFTQKYLFGFDPYVHLSVIREFLNGNIRDNLIYPLSLAPYGARINEPLGIYYVPILIFKILKLLGLSLYDAFRITPVLFGILTIIFFYSFIAKLHGKKCAIYSVLFLAISFAHISRSMANYYRADNYAVFLFSIVLWAFGALLQKTDFNVHTAFYIATAGIALGISCAFWGGYIALFVFVFGILFFSLVASLLKKGKQHFYSSIYVLLSIISGGVIVFLIGPKVNYHYFQNFSKVFMYPLIFVILLFGFTLLSLRFELSNKAKISTIIIMSIVAVFGVSYYNPTLFKELLTGFGYLNSSGVYRTIMELRRPTPFDLWIGFGISIFLVPFYFLHMKKNSLLFIHLGWIIPSMYLLLNAVRFIFLASLAIAFMAGIGLVEIENIMKSIKFISKKASMAIIMSIFLLTGYLSFASLKNLHPVMDQNWENALLYLKSHSNETDIVLAWWDYGGFIQYYAERPTLTDSVYGQVMAKYVARYYLGLVPTQELKRRGVKYVIVNKELILKFGTIIRTANESGGYLMVMLPLDYTLGNTLVFSNHNIIFVLKRDGEWLGTLQIGGRKIKISRLLVESNDIKEVQLDKDGLILYANLNYGYAVVMDEKAFNTKFSQLMFRNKGDLIYSDGGTIKIFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM23</accession>
    <name>F0LM23_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AcnX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467168.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00893"/>
    <dbReference type="EnsemblBacteria" id="ADT83870">
        <property type="protein sequence ID" value="ADT83870"/>
        <property type="gene ID" value="TERMP_00893"/>
    </dbReference>
    <dbReference type="GeneID" id="26136338"/>
    <dbReference type="KEGG" id="tba:TERMP_00893"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.895"/>
    <dbReference type="eggNOG" id="arCOG04278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018825_1_0_2"/>
    <dbReference type="OMA" id="CTCTPYL"/>
    <dbReference type="OrthoDB" id="31127at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01355">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007506">
        <property type="entry name" value="AcnX_catalytic_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04412">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcnX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="386" mass="42602" checksum="F2D460D4682C3E47" modified="2011-05-03" version="1">MYLTKEEELILAGEYGYALQKAMEILVALGEIYGADRLIPIKSAQIAGVSYKNIGDAGIEFLRDFVDAGAKVSVYTTLNPAGIGNEEFMEKQREVLELYKAMGIEITSTCTPYYGANLPKFGDHLAWSESSAVSFANSIIGARTNREGGPSSLAAAIVGKTPNYGLHLEENRKATVIVEIQAKVKDFVDYSFLGYHLGKILKNDVPYFRGLRPEKTDYLKELGASMAATGSIALYHVEGETPEYKTAITDKLERIQVDDKELKEVKEKYNAGWDEIDAILIGCPHASIHEIKEVAELLRMRGKPLKVPLFITASRVVRYLADSLGYTEVIERYNGKIVVDACLIVSPIKSWYKGIATNSGKASFYFSSAGLKVRLDNTDKLILEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM43</accession>
    <name>F0LM43_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-guanine(15) transglycosylase</fullName>
            <ecNumber evidence="3">2.4.2.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">7-cyano-7-deazaguanine tRNA-ribosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Archaeal tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tgtA</name>
        <name evidence="5" type="ordered locus">TERMP_00914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7-carbaguanosine(15) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:43164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10371"/>
            <dbReference type="Rhea" id="RHEA-COMP:10372"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82850"/>
            <dbReference type="EC" id="2.4.2.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">tRNA modification; archaeosine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeosine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.48" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467188.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00914"/>
    <dbReference type="EnsemblBacteria" id="ADT83890">
        <property type="protein sequence ID" value="ADT83890"/>
        <property type="gene ID" value="TERMP_00914"/>
    </dbReference>
    <dbReference type="GeneID" id="10041231"/>
    <dbReference type="KEGG" id="tba:TERMP_00914"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.915"/>
    <dbReference type="eggNOG" id="arCOG00989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00991">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030083_0_0_2"/>
    <dbReference type="OMA" id="FPCSCPV"/>
    <dbReference type="OrthoDB" id="10236at2157"/>
    <dbReference type="UniPathway" id="UPA00393"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01634">
        <property type="entry name" value="TgtA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038370">
        <property type="entry name" value="ArcTGT_C1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032729">
        <property type="entry name" value="TGT_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029402">
        <property type="entry name" value="TGT_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038250">
        <property type="entry name" value="TGT_C2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004804">
        <property type="entry name" value="TgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14809">
        <property type="entry name" value="TGT_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14810">
        <property type="entry name" value="TGT_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00432">
        <property type="entry name" value="arcsn_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="503"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="578" mass="66114" checksum="0A779B0C28BD6A82" modified="2011-05-03" version="1">MFKFEIKARDAAGRIGRLEVNGKKIETPAIMPVVNPKQLIVTPKELRKMGFHIIITNSYIIYKDEELRQKALEMGIHKLLDYDGIIEVDSGSFQLMRYGGVEVTNREIIEFQHKIGVDIGTFLDIPTVPDAPREKAEEDLRITLERAKEAEEIKQVPMNATVQGSTYLDLRTYAAKKLSEMNFEIHPIGAVVPLMESYRYRELVDVVVASKLGLRPDRPVHLFGAGHPMIFALAVAMGIDLFDSASYALYAKDDRYLTPEGTKHLSELEYFPCSCPVCSRYTPQELKEMPKEKRVKMLALHNLWVIREEINRVKQAIKEGELWRLVDERSRSHPKLFSAYKRLLEYRDYLEENEPITKSSAFFKVSEEIMGTPIVWRAKQRAERVKQKFSETINHPIFGEIPKYLSLSYPFAQSEGEEDFTIEKPKKNEAKLYIQAVAEYQFGEGAAEAFKDAFVELSRKTGMPRQIKAKGKHLATFRAEDGLLTLGIEGAKRVHQILPYPRMRVVVNEDAEPFARKGKNVFAKFVIDADENIRPYDEVLVVNKNDELLATGQTLLSGKELKIFQQGLAVKVRRGIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM49</accession>
    <name>F0LM49_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-S18p-alanine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467194.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00920"/>
    <dbReference type="EnsemblBacteria" id="ADT83896">
        <property type="protein sequence ID" value="ADT83896"/>
        <property type="gene ID" value="TERMP_00920"/>
    </dbReference>
    <dbReference type="GeneID" id="26136364"/>
    <dbReference type="KEGG" id="tba:TERMP_00920"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.921"/>
    <dbReference type="eggNOG" id="arCOG00833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_0_2"/>
    <dbReference type="OMA" id="SGEIMGY"/>
    <dbReference type="OrthoDB" id="95090at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="169" mass="19450" checksum="777CD164822306C9" modified="2011-05-03" version="1">MSASSRDLPQMKRIPLSLVVIRPAKLFDLPEIVRIEHQSFREQYPRGLFMMFLENNPDTFLVAEYNGKVVGYVMAYLKPDLEGHVMSIAVDPLYRGNGIGKALMISVINKLIERGAKYIGLEVRVSNERAIKLYERLGFRKVKRIIGYYSDGEDAYYMVLPANEWREGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM69</accession>
    <name>F0LM69_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467214.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00940"/>
    <dbReference type="EnsemblBacteria" id="ADT83916">
        <property type="protein sequence ID" value="ADT83916"/>
        <property type="gene ID" value="TERMP_00940"/>
    </dbReference>
    <dbReference type="GeneID" id="10041257"/>
    <dbReference type="KEGG" id="tba:TERMP_00940"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.943"/>
    <dbReference type="eggNOG" id="arCOG01879">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1369577_0_0_2"/>
    <dbReference type="OMA" id="YNRKIIH"/>
    <dbReference type="OrthoDB" id="87824at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="199" mass="22449" checksum="B523A360A3584295" modified="2011-05-03" version="1">MIYAGVAAAFILFAIWITRYLGEEYAWVNRKIIHFSIVPAVLFYNAGLIARELFAAAAFLFGAFQLFTHIKKDELSWYQIRSNYGEVFFAFSAAAVAWFIEKEYAVVILLVMAISDGVTGILRFFYFKAKGFDVRLRKHWIGSLGYLISALIIVAIIFPQSSIVSKVIWAGILTLAEYQRFLDDNLAVPLVGILIKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMD3</accession>
    <name>F0LMD3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468452.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02182"/>
    <dbReference type="EnsemblBacteria" id="ADT85156">
        <property type="protein sequence ID" value="ADT85156"/>
        <property type="gene ID" value="TERMP_02182"/>
    </dbReference>
    <dbReference type="GeneID" id="26137818"/>
    <dbReference type="KEGG" id="tba:TERMP_02182"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2177"/>
    <dbReference type="eggNOG" id="arCOG04051">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174522_0_0_2"/>
    <dbReference type="OMA" id="PHAQMAK"/>
    <dbReference type="OrthoDB" id="119555at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007355">
        <property type="entry name" value="DUF424"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04242">
        <property type="entry name" value="DUF424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="100" mass="11565" checksum="A2041E3BC8AD0A26" modified="2011-05-03" version="1">MKIYVKVYRVQGEVLLAACDEELMGKTFREGELKLEVKERFYKGELRDVEDLEKLLEEATIANLVGERCVGKAIELGYIDKDRVLYIQGVPHAQMAKMLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMF9</accession>
    <name>F0LMF9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468478.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02208"/>
    <dbReference type="EnsemblBacteria" id="ADT85182">
        <property type="protein sequence ID" value="ADT85182"/>
        <property type="gene ID" value="TERMP_02208"/>
    </dbReference>
    <dbReference type="GeneID" id="10042523"/>
    <dbReference type="KEGG" id="tba:TERMP_02208"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2203"/>
    <dbReference type="HOGENOM" id="CLU_607829_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="450" mass="51290" checksum="FD4D83BEDEA9B628" modified="2011-05-03" version="1">MKKRLLSVMFLLLLSYPFGSAANLTDTFVTINTTEQVILLNQMPSTDFHIRLPIKIPYGYRLEGFDVYFNTSNDTIMRKFWLQWADGNISMPSTFGIHWLNNTTAKFSARFNVAPGFYIAHFKLKFPEKAVPLKIIVHTKKDELKLPTRMHIAYKTAEIHGVYGFARSKFSFTAFGNLLGVEIHRIEGSEKKNNRAPEGALVYGNGSVKVSEGYISFNPPLPPGRYSLSLSAPATIKAYYAIPINETVNLSKIKFTRYGVLFEELSYPPWDELNLTLDFFWNGKDITVARLALPRYPYMADVKLNPDKTLCISGESEYYGYIDKCAVLEGYGKGFVRLGIRLVRDYEGKRYLEIGEIRINSAEIIGENWYFLPLIRVEVDSPIGVRMLGVKKDSLINFEVSAVRKSNYYIVPCTCSGYAHFDDRAIPILITAVLLMPLIIYALLEWRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMI4</accession>
    <name>F0LMI4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Triphosphoribosyl-dephospho-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467261.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00987"/>
    <dbReference type="EnsemblBacteria" id="ADT83963">
        <property type="protein sequence ID" value="ADT83963"/>
        <property type="gene ID" value="TERMP_00987"/>
    </dbReference>
    <dbReference type="GeneID" id="10041304"/>
    <dbReference type="KEGG" id="tba:TERMP_00987"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.990"/>
    <dbReference type="eggNOG" id="arCOG04238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063627_0_0_2"/>
    <dbReference type="OMA" id="GNTHFGA"/>
    <dbReference type="OrthoDB" id="62406at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046917">
        <property type="term" value="F:triphosphoribosyl-dephospho-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002736">
        <property type="entry name" value="CitG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01874">
        <property type="entry name" value="CitG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="296" mass="33908" checksum="01EB50597A3B7B66" modified="2011-05-03" version="1">MERWKIIKAFTLGPLLEVMIPKPGNVNRFKDFEDLTLYHFLFGNVAVVDILYEATEVSRLIKRGDYQLSEANIGEMIKRAVQNAKATQDANPNFGIIALEIPLVIALTISKNLYDARELVKRLIEHSTVRDAMEFYKAIRIANPKGIKSGVKYDVYDENVFDELFRDRINLKRLAEISCERELIFCEWLNGYELSYKTFLRLKELTKKFSLEEAVLNAFIELLASTPDTLIIRKAGKTEAELVMRKARETLDGTFSIDELDKFLREKGDLRNPGSLADITAIALSLLILDGYKFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMM0</accession>
    <name>F0LMM0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP phosphorylase</fullName>
            <shortName evidence="3">AMPpase</shortName>
            <ecNumber evidence="3">2.4.2.57</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Nucleoside monophosphate phosphorylase</fullName>
            <shortName evidence="3">NMP phosphorylase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate</text>
            <dbReference type="Rhea" id="RHEA:36975"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:68688"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.57"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>CMP + phosphate = alpha-D-ribose 1,5-bisphosphate + cytosine</text>
            <dbReference type="Rhea" id="RHEA:36987"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:68688"/>
            <dbReference type="EC" id="2.4.2.57"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + UMP = alpha-D-ribose 1,5-bisphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:36991"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:68688"/>
            <dbReference type="EC" id="2.4.2.57"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.57" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01023"/>
    <dbReference type="EnsemblBacteria" id="ADT83999">
        <property type="protein sequence ID" value="ADT83999"/>
        <property type="gene ID" value="TERMP_01023"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01023"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1026"/>
    <dbReference type="eggNOG" id="arCOG02013">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025040_6_0_2"/>
    <dbReference type="OMA" id="DVWRRMI"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046125">
        <property type="term" value="P:pyrimidine deoxyribonucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02132">
        <property type="entry name" value="AMP_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017713">
        <property type="entry name" value="AMP_phosphorylase"/>
    </dbReference>
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        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
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        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
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        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
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        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013466">
        <property type="entry name" value="Thymidine/AMP_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50692"/>
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    </dbReference>
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        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03327">
        <property type="entry name" value="AMP_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02645">
        <property type="entry name" value="ARCH_P_rylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="4">
        <location>
            <begin position="435"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="205"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="514" mass="55513" checksum="F14549E862348910" modified="2011-05-03" version="1">MEYCQPFGGRSMKAKIKILDVYTGRFVVVINEKDAKRVKLHPEDLVKIETGKKTVYGDVVISNMVEEGEIGLSKDVLQVHSFSQGEIVNIAPAGTPESIRYIKKKMHGAKLRKVEIESIIKDIVDRKLREIEISAFVTALEVNGLDMDEIAWLTVAMAETGDMLDIDRKPIMDVHSIGGVPGNKTNILVVPIVAAAGLTIPKTSSRAITSAAGTADVVEVLTNVSLSLDEIKRIVEKIGACLVWGGALNLAPADDITIKAERALSIDPRGLMLASIMSKKYAMGSQYILIDIPTGKGVKVETMEEARSLARDFIELGKRLGQYVEVAITYGGQPVGHTVGPALEAKEALQTLMTGKGPGSLVEKATGLAGILLEMGGVAPAGMGKKMAREILESGKAYQKMREIIEEQGGNPDIKPEEIPIGDKTYTFTAPTSGYITFIDNKAITGIARAAGAPEDKGAGLELYVKVGEKVREGDPLFKIYAESEARLEQAIVYARRTEPIRIEGMVLQRIGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMN9</accession>
    <name>F0LMN9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophanate hydrolase 2 subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
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    <dbReference type="STRING" id="391623.TERMP_01042"/>
    <dbReference type="EnsemblBacteria" id="ADT84018">
        <property type="protein sequence ID" value="ADT84018"/>
        <property type="gene ID" value="TERMP_01042"/>
    </dbReference>
    <dbReference type="GeneID" id="10041359"/>
    <dbReference type="KEGG" id="tba:TERMP_01042"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1045"/>
    <dbReference type="eggNOG" id="arCOG05808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028967_0_1_2"/>
    <dbReference type="OMA" id="QDLGRSH"/>
    <dbReference type="OrthoDB" id="46304at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="23"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="331" mass="36474" checksum="D1D25C16B9D5029F" modified="2011-05-03" version="1">MIELVNVPSLTTIQDLGRYGYQKFGIPVSGVMDEVSARLANYLVGNHDNASLIEFVLKGPTIRFHSSAVFAVAGDVDVRLNGIPIEPWQSHWAKRGDVLEIGLLKSGVYGYIAFAGGILCDKILGSCSTYLRAKLGKPLKQGDKLKLGYAILAGKEGRVLPEPLIPRYSNESEIRVILGPQLEHFTEKGIETFLSSTYEVTPNSDRMGYRLEGPEIEHSEKGADIITDAIPLGAIQVPANGKPIIMLADRQTTGGYAKIGVVARVDVPKVAQTRAGGKLRFKAINVEEAQELFRKREFLFRSIKRLLDGEVRGYKIKALGKEFMVFVEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMP9</accession>
    <name>F0LMP9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01052"/>
    <dbReference type="EnsemblBacteria" id="ADT84028">
        <property type="protein sequence ID" value="ADT84028"/>
        <property type="gene ID" value="TERMP_01052"/>
    </dbReference>
    <dbReference type="GeneID" id="10041369"/>
    <dbReference type="KEGG" id="tba:TERMP_01052"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1055"/>
    <dbReference type="eggNOG" id="arCOG05024">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_3_3_2"/>
    <dbReference type="OMA" id="RHAYHAT"/>
    <dbReference type="OrthoDB" id="112390at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ribonuclease activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="121" mass="14291" checksum="0FE14F2C0B92C1E5" modified="2011-05-03" version="1">MKRDYTLYLRDIIEAMESIERFIEGMSFEDFVADDKTVSAVLRKLEIIGEAAKHISPHIRERYDDVPWKQMAGMRDKLIHFYFGVDYELVWRTVTVRIPEIKKRLIEILSELKGDQNGAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMR8</accession>
    <name>F0LMR8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467345.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01071"/>
    <dbReference type="EnsemblBacteria" id="ADT84047">
        <property type="protein sequence ID" value="ADT84047"/>
        <property type="gene ID" value="TERMP_01071"/>
    </dbReference>
    <dbReference type="GeneID" id="10041388"/>
    <dbReference type="KEGG" id="tba:TERMP_01071"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1074"/>
    <dbReference type="eggNOG" id="arCOG02733">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_707166_0_0_2"/>
    <dbReference type="OMA" id="KHYEKAS"/>
    <dbReference type="OrthoDB" id="40339at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="395" mass="45676" checksum="6C498F26DF3CB556" modified="2011-05-03" version="1">MPFNPFTSSPEDLEGIGYKRITDGKIKEGLKYLIKAAKGYEEIGKLMDAARLYKYIGVSLLNKTKTPQKARPFLLKSAYMYLHLIEEEIEKIEINLIKLEDFCLNVLEIFTLLNDEKNLKKYTREFAVMYEDLANAYLDTDDIESAIAAYETSYRYYKLIGDLDGVRIAAERLIDLYGKLAEQYLENGYYNEAGDTFFRLGYFVKDLFDYDSHFIEILDTAGKNYERASKEAYAEGDLDQTTERLLKAEYAYLLARNFNRAKLIGLNVSRMLYQLVNSYRSKGKFEKVGDKLLQLAEALIGVGKIENGLEVYKTALEESKGKINYRVRIRTALLRYLAAKKKDVTILERIEQIEFYSKRADYIKALEIAEKIISEYPELKEIKNKLYHAEGIVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMR9</accession>
    <name>F0LMR9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467346.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01072"/>
    <dbReference type="EnsemblBacteria" id="ADT84048">
        <property type="protein sequence ID" value="ADT84048"/>
        <property type="gene ID" value="TERMP_01072"/>
    </dbReference>
    <dbReference type="GeneID" id="10041389"/>
    <dbReference type="KEGG" id="tba:TERMP_01072"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1075"/>
    <dbReference type="eggNOG" id="arCOG05517">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1840684_0_0_2"/>
    <dbReference type="OMA" id="KEMRIPY"/>
    <dbReference type="OrthoDB" id="100379at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="139" mass="15865" checksum="20D724F7E088CE08" modified="2011-05-03" version="1">MPVLGINITKIQIEKKGGVIGRVEVNLSPQIKEVRLGELRMPTGKVNGIEILFEYRINYRPEVASAVVEGMVFYLPPQKEQIDGILDLWEKEKKVRPEVFAEVVNFITNEISPFLMIAAKDMKIPYHIPLPRVALKPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMS9</accession>
    <name>F0LMS9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467356.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01082"/>
    <dbReference type="EnsemblBacteria" id="ADT84058">
        <property type="protein sequence ID" value="ADT84058"/>
        <property type="gene ID" value="TERMP_01082"/>
    </dbReference>
    <dbReference type="GeneID" id="10041399"/>
    <dbReference type="KEGG" id="tba:TERMP_01082"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1085"/>
    <dbReference type="eggNOG" id="arCOG06986">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074026_0_0_2"/>
    <dbReference type="OMA" id="FIVELEM"/>
    <dbReference type="OrthoDB" id="69672at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="310" mass="34417" checksum="0E8B5517DC746DBA" modified="2011-05-03" version="1">MKTILIKPKGGKIISAIFVVFFILFLLPVVFVYTHTSGGKTFLLLFMAFAALLFVAGVYFQHAILKQAKKAESLFSIVSISESGISFPEELEFEYGILNMKAWWSSSGKSRSYHVSREFISAGTARASNIPFINAEFKMLITADGSGFVSAPAVKILSEPYKDVVFLFLTEKGKVDANGTLVLSTDNDSAQIIVKGVEENIAGRVYSTLNKARKVKIAISAPESTYEIPIAEGDNFEFSYRMLPEEKILIAGGYSVVDPNRIRKYLNKREVAMGHGEFILTGTLDLPLRRDVSESITFNVSLEERDEWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMU0</accession>
    <name>F0LMU0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467367.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01093"/>
    <dbReference type="EnsemblBacteria" id="ADT84069">
        <property type="protein sequence ID" value="ADT84069"/>
        <property type="gene ID" value="TERMP_01093"/>
    </dbReference>
    <dbReference type="GeneID" id="10041410"/>
    <dbReference type="KEGG" id="tba:TERMP_01093"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1096"/>
    <dbReference type="eggNOG" id="arCOG00037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1381418_0_0_2"/>
    <dbReference type="OMA" id="FYDVTLV"/>
    <dbReference type="OrthoDB" id="71195at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="201" mass="23612" checksum="CCF9F2217287BA52" modified="2011-05-03" version="1">MEVYHLYSGGKDSSLAAWILQKLGYEVKLVTISFGLLDNWKYAKETADRLGFNHEVVVLGREILEEAAEMCIRDGHPSNAIQFIHEKALEEIASRKDVERISDGTRRDDRVPFLDLRRTRSLEDRFNVQYIRPLLGLGYKTIRELAEKLFIIEIRESEKLEKSDYEVELRHLLRLRGIDPLTIFPKRHYQSRVLGWKKQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMV2</accession>
    <name>F0LMV2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEGA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467379.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01105"/>
    <dbReference type="EnsemblBacteria" id="ADT84081">
        <property type="protein sequence ID" value="ADT84081"/>
        <property type="gene ID" value="TERMP_01105"/>
    </dbReference>
    <dbReference type="GeneID" id="10041422"/>
    <dbReference type="KEGG" id="tba:TERMP_01105"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1108"/>
    <dbReference type="eggNOG" id="arCOG02491">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03264">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_420728_0_0_2"/>
    <dbReference type="OrthoDB" id="36810at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="2">
        <location>
            <begin position="411"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="651" mass="73209" checksum="BFF7A6EDBC687D9A" modified="2011-05-03" version="1">MKKLALLLLLLVCSSQAGAVYVEMWEKKVDGIEGGFPMIMPEIIAVGNYFIPLRIIAGFYIFNESGVVYENKFLSIARVVKKDDLLLISFYDSAVLFNFSKRIVRKTLVHERYIMGVTFLGNNPVTLSRNGKVKVFDTNGSLLWSREFRYAQWITACSGKLVVYGFAGNGSQVVVFDNSSELRLRFDEFVDGAECAGNSLIILERNRSVSRVMSYSLNGTLRWIKDFGKPYIRVHAVSNRIYVSDWTNDVLMIFDLNGNLLANLRISRINLLGASPTSYEITEKGIIMVWNDRVEVYSNDGRLIKNLSISVGKGQIFGAQVYNGTVLVYGGSPSVGFPIEKPYGFVLLLKDNRSELIEFPGPVGFAGFFRGNLVVITIGYLQERLDTPTRDFAYIPDYRVVLLKKAPGGYINITSNLEGKVYIDGKFAGETPLRTGLERGRHNITVVAFGKMKSKVIDVNDYDMNITFKFAAGVLNVSSAVEAWLKTDNKSLGKGPGEFYLPPGNYNITFYCFGCLGRMSYFGELYYGVRIKENETTMIFINTSILKNPIGYLMLPCNITEVAIDGKPLRNIFMLPLSAGEHEIELYGRALRVSLKENEVLVLKLDRSRRTYTTTVAITRASELQRVFGFEVVLALFLALLVFREVMREKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMV9</accession>
    <name>F0LMV9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell division protein FtsH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467386.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01112"/>
    <dbReference type="EnsemblBacteria" id="ADT84088">
        <property type="protein sequence ID" value="ADT84088"/>
        <property type="gene ID" value="TERMP_01112"/>
    </dbReference>
    <dbReference type="GeneID" id="10041429"/>
    <dbReference type="KEGG" id="tba:TERMP_01112"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1115"/>
    <dbReference type="eggNOG" id="arCOG01308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_2"/>
    <dbReference type="OMA" id="YMMEYYR"/>
    <dbReference type="OrthoDB" id="2808at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="5">
        <location>
            <begin position="14"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="4">
        <location>
            <begin position="116"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="243"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="578"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="834" mass="94380" checksum="17CFF3B8D26B3F99" modified="2011-05-03" version="1">MILGKRDEVKDEIKLRVAEALKRDVGRGIVRFDRKYQRELGVEPGDIVELEGERSTAAIVANAHPDDRGLDIIRMDGYIRRNAKVSIGDYVTVRRAEVKEAKKVVLAPAQRGVLIQIPGDMIKQNLLGRPVVKGDIIVASGREEFYTGSPFDEFFRGFFEALPLAFGELKFIVVNTNPKGIVQITYNTEIEVLPQAVEVREEKVPEVTYEDIGGLKDAIQKIREMVELPLKHPELFERLGIEPPKGVLLYGPPGTGKTLLAKAVANETNAHFIAINGPEIMSKFYGESEERLREVFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVSQLLTLMDGLKKRGKVIVIAATNRPDAIDPALRRPGRFDREIEVGVPDKQGRKEILQIHTRGMPLEPDYDKPSVLKVLKEFLKEERFDKKKLEEIIKKVEKAKDEDEIKEILKSDGEIYREVKAKLIDKMLDELAEKTHGFVGADLAALAREAAMVVLRRLIQEGKINPEEEKIAPEVLQELKVTKRDFYEALKMVEPSALREVMLEVPNVHWEDIGGLEDVKQALREAVEWPLKYPKAFQRLGINPPKGILLYGPPGTGKTMLAKAVATESEANFIGIRGPEVLSKWVGESEKRIREIFRKARQAAPTVVFIDEIDAIAPMRGSDVNRVTDRIINQLLTEMDGLEENSGVVVIAATNRPDILDPALLRPGRFDRLILVPAPDEKARYEILKVHTRRVPLAEDVNLKELAKRLEGYTGADIAALVREAAMNALRRTVAKIPRELIEEQSEEFLEKLKVSRKDFEEAMKKIRPSVTKYMIEYYKQFEESRKAPKERKEMDYFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMZ6</accession>
    <name>F0LMZ6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467423.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01149"/>
    <dbReference type="EnsemblBacteria" id="ADT84125">
        <property type="protein sequence ID" value="ADT84125"/>
        <property type="gene ID" value="TERMP_01149"/>
    </dbReference>
    <dbReference type="GeneID" id="10041466"/>
    <dbReference type="KEGG" id="tba:TERMP_01149"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1152"/>
    <dbReference type="eggNOG" id="arCOG01545">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_2_2"/>
    <dbReference type="OMA" id="PWYQNFI"/>
    <dbReference type="OrthoDB" id="88886at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="293" mass="32805" checksum="BA26F1AD0E697CC9" modified="2011-05-03" version="1">MNIIFMAINLAFALLIAPIVDGLERKIRARLQNRQGPSILQTWWDLIKLFKRPTVEPQDSVKSFYKLAPYVTFTAVLTAYLIVPTLLPSSINFIGDFIVVVYLLGLATLSFVIGAFSSGNPYAQIGSNREVSLFMSEELLLAFIVGTIAVIGKSLSFDQLFPLPLRISSVLALLLLLLVIYVASARLPFDIAEAEPEIIEGPLIEYSGKHLGLLEYSIFLKRLLLYSLLLNFILPIQNPTRLIGYLLGIMILSMIYSIFEAYYGRFRIDQAVKLMKKLSALALIVWLIAVVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN21</accession>
    <name>F0LN21_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetate--CoA ligase (ADP-forming)</fullName>
            <ecNumber evidence="2">6.2.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15081"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.2.1.13" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467448.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01174"/>
    <dbReference type="EnsemblBacteria" id="ADT84150">
        <property type="protein sequence ID" value="ADT84150"/>
        <property type="gene ID" value="TERMP_01174"/>
    </dbReference>
    <dbReference type="GeneID" id="10041491"/>
    <dbReference type="KEGG" id="tba:TERMP_01174"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1177"/>
    <dbReference type="eggNOG" id="arCOG01340">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007415_2_3_2"/>
    <dbReference type="OMA" id="EDFEHMF"/>
    <dbReference type="OrthoDB" id="15044at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="473" mass="51491" checksum="7FA322B886486B0B" modified="2011-05-03" version="1">MEMPKIVEELKPFFEPKAVAIIGATNKKGKVGNVIFENFKRNKEQGIFKGNIYPVNPKLDEIEGYKVYKSVKELPKDTDLAVISIPAPFVPATMKDIAEKGIKAVIIITGGFGELGEEGKRLEREIYEIAKANGIRVIGPNCVGVYVPDTGVDTVFLPEEKMDRPKSGPIAFVSQSGAFAAAMLDWAALAGIGIGKMVSYGNKIDVDDADLMDYFIYDDQIKVVTFYIEGVKDGRKFIEAAKRITKVKPVIALKSGRTEYGAKAASSHTGSLAGADVIYDAVFKQTGIIRAEDFEHMFDVAKAFAKCRLPKGDRIGIITDGGGAGVMASDAVAKFGLKMAQLSEETLKFLKENFPPHAVAGNPTDVVGDTDAQRYKIAIEGFVNDPNVDAILVIVLFQVPLLNEMEIIEILSEYAKNSEKPIVAVAMGGKKTEYYAKLLEEKGVPVYPTPERGVRALAGLVQYAKYLEKVEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN48</accession>
    <name>F0LN48_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_02214</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="10 11">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
            <plasmid evidence="10 11">pTBMP1</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747409.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02214"/>
    <dbReference type="REBASE" id="29891">
        <property type="entry name" value="TbaMPORF2214P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT85187">
        <property type="protein sequence ID" value="ADT85187"/>
        <property type="gene ID" value="TERMP_02214"/>
    </dbReference>
    <dbReference type="GeneID" id="10549038"/>
    <dbReference type="KEGG" id="tba:TERMP_02214"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2208"/>
    <dbReference type="eggNOG" id="arCOG02632">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02635">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG05724">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_270917_0_0_2"/>
    <dbReference type="OMA" id="HEENIGD"/>
    <dbReference type="OrthoDB" id="1425at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025931">
        <property type="entry name" value="TaqI_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12950">
        <property type="entry name" value="TaqI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0614">Plasmid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="8">
        <location>
            <begin position="415"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="8">
        <location>
            <begin position="723"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="TaqI_C" evidence="9">
        <location>
            <begin position="959"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT85187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1199" mass="140029" checksum="B917F465B45AA708" modified="2011-05-03" version="1">MPQAVLTFGIEVPKNVYEKWGKFLELANKINADLGSYPKVRRKLEGILRGQNITITSEDCEDQQPEPFTRQHVIDPLLKFLGYELTPEVVKRTVSVLGSSMIKKIKQPDYRVKSIFGEEILIEAEPLGSNLYKKGSGVNQVIEWLDRRSFNVDIGIATNGFEWILLYYDNTSKEIKTLAEIDLAPIFNYLSKREKGLIIGYSVKELRELFVRFYYAFSREYIEEYIEGRTKFIREKKEAITKKFYDDFIYYVFGYREVKTNSKTKLKKVTNNCLYDKIKAPLDATEEDKQKFAVVLMNRLIFVKFLEDKGLVPGGLLKRTFEEWRNSSVPVSYYKAYLEPLFFGVFNTPEEERDRKVIEHFRDIPYLNGGLFRENLRNEKQYDIPDDNVMEEIIKFLERYDFTLGSKSNEESLDPDILGHVYEKLINLLTNKGQKGLGAYYTPEEVTRTIVKSTVEPVVIKKLKEVLKKWGWQEQLLNFSTLDEVLNEDRPITRDGRVLKDFLDEINKMKILDPAVGSGHFLISVLKELLEIKKRVHSLIGEEFNTYKLKLEIILNNLYGVDIDETAVEVAKLRLWLALIEDLDVDAVRRGDVILPNIEYNVRVGNSLVGWIGERLTIATLDYPYDKKVEGIFIGLKALATGEEAVKIKKAEELLKDHSSTVKDYVEAYCILYEIYKNNVGKKAAILKEILESIRRRIYQRVSGEYFNFINDTINENRRKKKKIKFDEDILKPFHWVVDFGWIMKEGGFDIIIGNPPYGNILSNIEKDIIDTRYREEEATYSVDSFLAFMRRSQELLKDGGYLGFIIPASFGTGVNYTKARKHFLQTMELKVFLYLPFDVFEGAYVDNSIIVLKNEEPSMDNEVLIYAFPKRSRLEELLTVWENPKIEKIRYSLLLNDPLCRIFPGGNVIYEILDHISSLSQRGNYDVYPLGDLTNSTIGILASKYKFSLVKLSKWHLPYLEGNVYRYITNLKQTKFVDFSQHKDNKDYLDLYLSKEKIMIRRIVSRQDRIMASFCNLQGVVKKDLYVFNLKSEFLSLVDYYYLLALINSKLLSFIYLGKSSIALKDDFRQTTLTELRELPIVIPHEDVIKDVVSALSKLLTELYSNVKYKKYCEFVDLLLDYLIYCIYFPEILPQSETEKIFEYLYTVVNKFNFWHDQIARELFTDDEVKEFIAKIRKKAGEHKFISIVEEKYMGDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGV4</accession>
    <name>F0LGV4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-threonine 3-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00015"/>
    <dbReference type="EnsemblBacteria" id="ADT82993">
        <property type="protein sequence ID" value="ADT82993"/>
        <property type="gene ID" value="TERMP_00015"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00015"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.14"/>
    <dbReference type="eggNOG" id="arCOG01459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_2"/>
    <dbReference type="OMA" id="TNCCLKA"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="31"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT82993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="398" mass="43517" checksum="8E734D684A39CA08" modified="2011-05-03" version="1">MDDMLAAVLYAKWDPKPEYKPTPKDIEGKLTYLGGLVWRYPELRVERRPIPKIKEDEVLIKVKACGICGSDIHMYESDKDGYILYPGLTAFPCVLGHEFSGEIVKVGEKAYNQWGEKFEVGTPVTAEEMVWCGYCRHCRDGYPNHCINLQEIGFSRDGAFAEYIAVPARVVWEITEIVERYGEKKGYEAGALVEPTSVAYNGIFERGGGFRPGAYVVVFGAGPIGLAGIALSKAAGAAKVIAVEIAEARQKLAKEMGADVVIDPTKIDSVSGKILEVTHGEGADMYVEAAGAFPKTWPAIEETIWNGEKVNAKVVAIGRAVTHVPLQFEVLQVRRAQVFGAQGHSGHGIFPSVINLMASGKIDMTKIVTHRFKLEDAAEALKFASKQKSNIGKVLIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGW4</accession>
    <name>F0LGW4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_00025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-alpha-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the mannose-6-phosphate isomerase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466301.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00025"/>
    <dbReference type="EnsemblBacteria" id="ADT83003">
        <property type="protein sequence ID" value="ADT83003"/>
        <property type="gene ID" value="TERMP_00025"/>
    </dbReference>
    <dbReference type="GeneID" id="26137878"/>
    <dbReference type="KEGG" id="tba:TERMP_00025"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.24"/>
    <dbReference type="eggNOG" id="arCOG02427">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_1_0_2"/>
    <dbReference type="OMA" id="LIVCNEK"/>
    <dbReference type="OrthoDB" id="33376at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006375">
        <property type="entry name" value="Man1P_GuaTrfase/Man6P_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01479">
        <property type="entry name" value="GMP_PMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="7">
        <location>
            <begin position="305"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="460" mass="52778" checksum="D41FBBBDF2A35A69" modified="2011-05-03" version="1">MKTLILAGGKGTRLWPLSRELMPKQFIRIFDDTSLFQKTVERALLFSKPKEIFIVTNKEYHFRVFDELRDMGIDIPEENVLLEPVGKNTLPAIYWGIRTINENFGKSKVAVLPSDHLVEVNEKYTDAFKKAEKLAEAYFVTFGVKPTKPHTGYGYIKPGEKLEVGYKVAEFKEKPDLETAKKYVEEGYYWNSGMFMFDTELFIEEVKKLTPDVYKAFEEAKSIEEAYEMVPDISVDYGIMEKTDKAAVVPLNVYWNDLGSFDSIYEAFKKDQNGNAVRIRGLKAEYIGIDSNNNLIITERLTATVGVRDLIIIDTGDALLVASRGEGQKVKLVYEKLKEKNDERAIVHRTAYRPWGSYTLLEEGDRYKIKRLTVLPGKRLSLQMHYHRSEHWVVVRGTAKVVVEDKEMLLRPGESVFIPAGVKHRLENPGKVVLEVIETQIGEYLGEDDIVRFQDDFGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGW6</accession>
    <name>F0LGW6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83005">
        <property type="protein sequence ID" value="ADT83005"/>
        <property type="gene ID" value="TERMP_00027"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00027"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.26"/>
    <dbReference type="HOGENOM" id="CLU_3323173_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="38" mass="4351" checksum="69290DCF9D5D738C" modified="2011-05-03" version="1">MKKGFSLLLVAFVVITIFLSNTKEKASKLLWRLRTLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH22</accession>
    <name>F0LH22_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467528.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01254"/>
    <dbReference type="EnsemblBacteria" id="ADT84230">
        <property type="protein sequence ID" value="ADT84230"/>
        <property type="gene ID" value="TERMP_01254"/>
    </dbReference>
    <dbReference type="GeneID" id="10041571"/>
    <dbReference type="KEGG" id="tba:TERMP_01254"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1257"/>
    <dbReference type="eggNOG" id="arCOG00288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_1_0_2"/>
    <dbReference type="OMA" id="TKAPYWL"/>
    <dbReference type="OrthoDB" id="121018at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="187" mass="21561" checksum="DAAB7EB9525DB4DF" modified="2011-05-03" version="1">MKVLELARRRKTVRKFLPEKPPFEDILKAIDAAKEAPSGMNAQPWHFVIVDDPWIKERIREVCEIGERKFYEKVSGKLGEWLKEKGFSPEKPFLSEAPYLILVFGYTKAPYWLHSTWIAVGYLLLALEELGLGTVTYTPPNPRAVEKLLNAPKEYKLQVILPVGYPADPKPKYERKKLEEVVSFNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHH8</accession>
    <name>F0LHH8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467603.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01330"/>
    <dbReference type="EnsemblBacteria" id="ADT84305">
        <property type="protein sequence ID" value="ADT84305"/>
        <property type="gene ID" value="TERMP_01330"/>
    </dbReference>
    <dbReference type="GeneID" id="26136815"/>
    <dbReference type="KEGG" id="tba:TERMP_01330"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1330"/>
    <dbReference type="eggNOG" id="arCOG00349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_6_4_2"/>
    <dbReference type="OMA" id="ESCPAFC"/>
    <dbReference type="OrthoDB" id="111853at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="60" mass="6417" checksum="F59E6F3F88164202" modified="2011-05-03" version="1">MKVKLDKDTCIGCGVCASICPDVFEMDDDGKAKVIMEETDLECAKEAAESCPTGSITIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHP0</accession>
    <name>F0LHP0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dimethylallyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466422.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00147"/>
    <dbReference type="EnsemblBacteria" id="ADT83124">
        <property type="protein sequence ID" value="ADT83124"/>
        <property type="gene ID" value="TERMP_00147"/>
    </dbReference>
    <dbReference type="GeneID" id="10040465"/>
    <dbReference type="KEGG" id="tba:TERMP_00147"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.148"/>
    <dbReference type="eggNOG" id="arCOG01726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_2"/>
    <dbReference type="OMA" id="CEGQALD"/>
    <dbReference type="OrthoDB" id="55053at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="342" mass="38277" checksum="1211162C310E6E79" modified="2011-05-03" version="1">MSKFDALFRSIKEKAKVVDDVIFELLPEKEPEELYEATRHYPLAGGKRVRPFVVLTAAEAVGGDWRKALYPAAAIEILHTYTLIHDDIMDMDETRRGRATVHKVWGINMAILAGDLMYSVVFDAATKAPVSAEKIVEIVRAIARAGIEICEGQALDLEFETRDTVTIEEYLKMIDGKTAALFDASAKIGGIIGTDNQEYIQALSKYGRNVGMAFQIWDDVLDLIADEKKLGKPVGSDIRKGKKTLIVAHFFQHASEEDKAEFLKVFGKYAGDVKGKGIIEEDIREEVAKVIELLKKYGSIDYASRFAKNLVKEAKEALKVLPESEARKNLELLADFIVEREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHR3</accession>
    <name>F0LHR3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0440 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00170"/>
    <dbReference type="EnsemblBacteria" id="ADT83147">
        <property type="protein sequence ID" value="ADT83147"/>
        <property type="gene ID" value="TERMP_00170"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00170"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.171"/>
    <dbReference type="eggNOG" id="arCOG05854">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2271176_0_0_2"/>
    <dbReference type="OMA" id="EVPIFVK"/>
    <dbReference type="OrthoDB" id="115180at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024502">
        <property type="entry name" value="DUF3194"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035954">
        <property type="entry name" value="MTH677-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11419">
        <property type="entry name" value="DUF3194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="106" mass="12274" checksum="ED424BD07FA94786" modified="2011-05-03" version="1">MTKRVIHIGLPELSEDELIALGELAQETAIEYIFEHLTRSEVKDIEVTARINKEETLDLELEIYLEVPIFVKVDVDKLVEEALELAYEKVEERLREIAHEGLQKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHS1</accession>
    <name>F0LHS1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466453.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00178"/>
    <dbReference type="EnsemblBacteria" id="ADT83155">
        <property type="protein sequence ID" value="ADT83155"/>
        <property type="gene ID" value="TERMP_00178"/>
    </dbReference>
    <dbReference type="GeneID" id="10040496"/>
    <dbReference type="KEGG" id="tba:TERMP_00178"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.179"/>
    <dbReference type="eggNOG" id="arCOG04218">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061502_0_0_2"/>
    <dbReference type="OMA" id="ICPFTTK"/>
    <dbReference type="OrthoDB" id="27038at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07894">
        <property type="entry name" value="Adenylation_RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041596">
        <property type="entry name" value="Lig_Pab1020_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001072">
        <property type="entry name" value="RNA_ligase_Pab1020"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18330">
        <property type="entry name" value="Lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01048">
        <property type="entry name" value="Y414FAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01209">
        <property type="entry name" value="TIGR01209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA_ligase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Lig_C" evidence="2">
        <location>
            <begin position="254"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="380" mass="44321" checksum="354CDA8F9ECFD175" modified="2011-05-03" version="1">MVSLHFKHILLKLGLDKERIEILEMKGGIVEDEFEGLRYLRFKDSAKGLRRGTVVFNESDIILGFPHIKRVVHLRNGVKRIFKSKPFYVEEKVDGYNVRVAKVGEKILALTRGGFVCPFTTERIGDFINEQFFKDHPNLILCGEMAGPESPYLVEGPPYVEEDIQFFLFDIQEKRTGRSIPVEERIKLAEEYGIQSVEIFGLYSYEKIDELYELIERLSKEGREGVVMKSPDMKKIVKYVTPYANVNDIKIGSRIFFDLPHGYFMQRIKRLAFYIAEKRIRREDFDEYAKALGKALLQPFVESIWDVAAGEMIAEIFTVRVKKIETAYKMVSHFERMGLNIHIDDIEELGNGYWKITFKRVYDDATKEIRELWNGHAFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHV5</accession>
    <name>F0LHV5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84355">
        <property type="protein sequence ID" value="ADT84355"/>
        <property type="gene ID" value="TERMP_01380"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01380"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1380"/>
    <dbReference type="HOGENOM" id="CLU_3094308_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="51" mass="5643" checksum="CEBAF1595F638B98" modified="2011-05-03" version="1">MRNIDGRRALRIPRAIIENVTPVNSVTWLRESSGISAAVIRIASEIVILIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHZ5</accession>
    <name>F0LHZ5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="6">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiI</name>
        <name evidence="9" type="ordered locus">TERMP_01420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiI family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467693.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01420"/>
    <dbReference type="EnsemblBacteria" id="ADT84395">
        <property type="protein sequence ID" value="ADT84395"/>
        <property type="gene ID" value="TERMP_01420"/>
    </dbReference>
    <dbReference type="GeneID" id="10041736"/>
    <dbReference type="KEGG" id="tba:TERMP_01420"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1420"/>
    <dbReference type="eggNOG" id="arCOG00038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037952_4_0_2"/>
    <dbReference type="OMA" id="SMPEFCG"/>
    <dbReference type="OrthoDB" id="57901at2157"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
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        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
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        <property type="term" value="P:tRNA thio-modification"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ThiI_AANH"/>
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        <property type="entry name" value="THUMP_dom"/>
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        <property type="entry name" value="tRNA_STrfase"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="8">
        <location>
            <begin position="53"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="171"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <begin position="196"/>
            <end position="197"/>
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        <ligand>
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        <location>
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        <ligand>
            <name>ATP</name>
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        <ligand>
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            <position position="285"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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            <dbReference type="ARBA" id="ARBA00022977"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
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        </source>
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    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84395.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="365" mass="41415" checksum="917472C479DA128E" modified="2011-05-03" version="1">MILVRYGEIAVKRGRRREFERKLMENILAALRRKGIEAKAELIRGRILVDAPDDAAKIIAKVPGVVSVSPAREMSYEEVPNYLREALKGLNPKSFKVETQRLDKTFLKTSVEINREIGAFIVREFGWKVDLENPELTIGIEIIKKKAYVFFEKIKGVGGLPVSTQGKVVALLSGGIDSPVAAFLMMKRGAEIIAVHFDQGKNARKVVEKTVNILNDYSPRDIELIIENHFEVLKPYVVALNRLNMREWTCVVCKIAMLRRAAEIAKEKGALGIVTGDSLGQVASQTLTNLYFETMSVRFPIHRPLLGMDKEEIIRIAREIGTYQAFLEYPYCDCPFRPERVVTQGKPEEFKRILDALEEMNKFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHZ7</accession>
    <name>F0LHZ7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferritin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467695.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01422"/>
    <dbReference type="EnsemblBacteria" id="ADT84397">
        <property type="protein sequence ID" value="ADT84397"/>
        <property type="gene ID" value="TERMP_01422"/>
    </dbReference>
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    <dbReference type="KEGG" id="tba:TERMP_01422"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1422"/>
    <dbReference type="eggNOG" id="arCOG01095">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065681_1_2_2"/>
    <dbReference type="OMA" id="CEDKGFE"/>
    <dbReference type="OrthoDB" id="87619at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferritin"/>
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        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
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        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
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        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="174" mass="20341" checksum="4C51F5D48274FC7E" modified="2011-05-03" version="1">MLSEKMLKALNEQLNRELYSAYLYFAMAAYFEDLNLEGFANWMKAQAEEELGHALRFYNYIYDRNGRVELKAIEQPPKEWDSPLAAFEAAYEHEQFITRHIHELAALAEEEKDYSTRAFLEWFINEQVEEEANVKKIVDKLKFAKDSPQVIFMLDQELGQRQPQLPGLLLQAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI09</accession>
    <name>F0LI09_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ordered locus">TERMP_01434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer of catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467707.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01434"/>
    <dbReference type="EnsemblBacteria" id="ADT84409">
        <property type="protein sequence ID" value="ADT84409"/>
        <property type="gene ID" value="TERMP_01434"/>
    </dbReference>
    <dbReference type="GeneID" id="10041750"/>
    <dbReference type="KEGG" id="tba:TERMP_01434"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1434"/>
    <dbReference type="eggNOG" id="arCOG00911">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_1_2_2"/>
    <dbReference type="OMA" id="FPTEREY"/>
    <dbReference type="OrthoDB" id="51351at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="155"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="310" mass="34953" checksum="DDFA90D7D3279220" modified="2011-05-03" version="1">MQGWKGRDVVSIRDFSKEDIEYVLNTAERLERELKEKGSLEYAKGKILATLFFEPSTRTRLSFESAMHRLGGSVIGFAEASTSSVKKGESLRDTIKTVEQYSDVIVIRHPKEGAARLAAEVAEIPVINAGDGSNQHPTQTLLDLYTIKREFGKIDGLKIALLGDLKYGRTVHSLSEALSHYDVELYLISPGLLRMPRHIVEELKEKGVKVYETSDLESVIGELDVLYVTRIQKERFPDEQEYLKVKGSYVIDLEILKKAKETLKIMHPLPRVDEIHPSVDSTKHAIYFRQVFSGIPVRMALLALTLGVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI38</accession>
    <name>F0LI38_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466490.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00215"/>
    <dbReference type="EnsemblBacteria" id="ADT83192">
        <property type="protein sequence ID" value="ADT83192"/>
        <property type="gene ID" value="TERMP_00215"/>
    </dbReference>
    <dbReference type="GeneID" id="10040533"/>
    <dbReference type="KEGG" id="tba:TERMP_00215"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.215"/>
    <dbReference type="eggNOG" id="arCOG02120">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116617_1_0_2"/>
    <dbReference type="OMA" id="NSHEFYI"/>
    <dbReference type="OrthoDB" id="81040at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="167" mass="19538" checksum="329342D961D48738" modified="2011-05-03" version="1">MERNRKKAQKARFRVVVDTSVLIAALMSSQGYAFEVIEKVLTGQITNYYSRKTLQEYKTVVAYPKIIKKISAEVAMLRVSAFVASSKLISIKKSLQKSKRIKELVKDEMDIPFLDVVYNAKAEFLITYDRKHLLKIRDKARKFKLNSHEFYILTPKEFIKEFYEVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI40</accession>
    <name>F0LI40_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466492.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00217"/>
    <dbReference type="EnsemblBacteria" id="ADT83194">
        <property type="protein sequence ID" value="ADT83194"/>
        <property type="gene ID" value="TERMP_00217"/>
    </dbReference>
    <dbReference type="GeneID" id="10040535"/>
    <dbReference type="KEGG" id="tba:TERMP_00217"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.217"/>
    <dbReference type="eggNOG" id="arCOG03058">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068892_2_0_2"/>
    <dbReference type="OrthoDB" id="108205at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="acidPPc" evidence="1">
        <location>
            <begin position="58"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="286" mass="32021" checksum="113D4F9BD4A993B8" modified="2011-05-03" version="1">MRKLDKALLIVSIFLMLSSVLAIHFQVYAFWKAITFLGYEKFYMVLIPVIYLGYSSSYGIALFIPFILGMWLNLFLKNFFKLPRPPENLRIVEAEGYGFPSGHAQGSSMVFGYFAYTREGIGFRVFCLTMIALISLSRIVLRVHYWRDIFGGIVLGTAVISLGVYLKNKVKYTPKVALLGIILSLLLPVISRSIGYANETFSIVEGSLIGAVVGYSSFKQFNLPDTSEIPFKKRMIMTAIGLFVSGAGYVVWKSGAPGLPTFAISTFTMVFLVPSAFLRFSDNYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI47</accession>
    <name>F0LI47_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00224"/>
    <dbReference type="EnsemblBacteria" id="ADT83201">
        <property type="protein sequence ID" value="ADT83201"/>
        <property type="gene ID" value="TERMP_00224"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00224"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.224"/>
    <dbReference type="eggNOG" id="arCOG12884">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2067925_0_0_2"/>
    <dbReference type="OMA" id="MEDSAWV"/>
    <dbReference type="OrthoDB" id="143255at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="118" mass="13142" checksum="C1C9470A455F3D33" modified="2011-05-03" version="1">MFSIMAGGFYALAILIENPKDKKEADEDFKRCLIILLGIIGGSMLLYSDPEALMKVMEDSAWVVKLASVASLIATVATVISYHRLKRFEQEEMLEKLAEKMGEKLGESRVKGLKAKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI80</accession>
    <name>F0LI80_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00257"/>
    <dbReference type="EnsemblBacteria" id="ADT83234">
        <property type="protein sequence ID" value="ADT83234"/>
        <property type="gene ID" value="TERMP_00257"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00257"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.257"/>
    <dbReference type="eggNOG" id="arCOG15250">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_219927_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="38" mass="4688" checksum="926A9D853672C565" modified="2011-05-03" version="1">MRDMEWLPLLHGYMIIREMEKKKKKPVPEELGYLEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIA2</accession>
    <name>F0LIA2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TldE/PmbA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467730.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01457"/>
    <dbReference type="EnsemblBacteria" id="ADT84432">
        <property type="protein sequence ID" value="ADT84432"/>
        <property type="gene ID" value="TERMP_01457"/>
    </dbReference>
    <dbReference type="GeneID" id="10041773"/>
    <dbReference type="KEGG" id="tba:TERMP_01457"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1457"/>
    <dbReference type="eggNOG" id="arCOG00322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_4_2_2"/>
    <dbReference type="OMA" id="LYRKSTF"/>
    <dbReference type="OrthoDB" id="49762at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="1">
        <location>
            <begin position="227"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="434" mass="48471" checksum="F34BD18309E2A57B" modified="2011-05-03" version="1">MIDELIKILNHKDVEWEIYWEIGRGSSFKVERCELVRAQRKYHSGVGLRIGYRGKVGFSYITGVNHDKNSLERFVNRTIKLAKVSEVPFYGFSTDNKHKKVKALYDRRIEEMSFDDAYSTALFLAEKERELKENLGSEYALSGGMAFGVSVDGIANSNGIEKSEKTTGLSVSVHIIKRAEKSGSGNYYKGFRLMPDLEEELSLGLGKALEEAELSYNAKKSSSYEGEIILEPHAVASLVSILMSNLYGDNVYHRRSRFSKLGDMIASEAFTLIDDATLEGKLGSYSFDGEGNPSQRTVLIERGILKNFLFDETYARLMDTKSTGNAVRDFRTTPHIGNSNVIVDGKNENLEDLEKAVVVKRVFGEHTANPVSGDFSLTVELGYIIERGEIKPFKDNMLAGNIFELISSIVSVGKKKEQIGSFLSPRVLVFGKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIC6</accession>
    <name>F0LIC6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF4040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_01481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01481"/>
    <dbReference type="EnsemblBacteria" id="ADT84456">
        <property type="protein sequence ID" value="ADT84456"/>
        <property type="gene ID" value="TERMP_01481"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01481"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1481"/>
    <dbReference type="eggNOG" id="arCOG03078">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173139_2_0_2"/>
    <dbReference type="OMA" id="WILQIFI"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="8">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="87" mass="9481" checksum="58AD7A0EF2B0D0BD" modified="2011-05-03" version="1">MNFMEFFWILQVLIGIGLLVSAIVAIRFKNLIMAVIAMAVFSLILSLEFYVLQAPDVAIAEAGVGAGLTTAMYLLAIKNTTDEEVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIE2</accession>
    <name>F0LIE2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane bound hydrogenase MbhB-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467770.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01497"/>
    <dbReference type="EnsemblBacteria" id="ADT84472">
        <property type="protein sequence ID" value="ADT84472"/>
        <property type="gene ID" value="TERMP_01497"/>
    </dbReference>
    <dbReference type="GeneID" id="10041813"/>
    <dbReference type="KEGG" id="tba:TERMP_01497"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1497"/>
    <dbReference type="eggNOG" id="arCOG03121">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125825_2_2_2"/>
    <dbReference type="OMA" id="YERAIYI"/>
    <dbReference type="OrthoDB" id="128222at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34702">
        <property type="entry name" value="PTHR34702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="87" mass="9425" checksum="89FCB13FC203B9E8" modified="2011-05-03" version="1">MIAPEFFYSALIIMIGAFLCVLRVLFGPTVPDRVVGVDTLNTLIVAGMILLGAAYDRVIYIDIAIVYALLSYIGTLVIAKYLQGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIE7</accession>
    <name>F0LIE7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467775.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01502"/>
    <dbReference type="EnsemblBacteria" id="ADT84477">
        <property type="protein sequence ID" value="ADT84477"/>
        <property type="gene ID" value="TERMP_01502"/>
    </dbReference>
    <dbReference type="GeneID" id="10041818"/>
    <dbReference type="KEGG" id="tba:TERMP_01502"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1502"/>
    <dbReference type="HOGENOM" id="CLU_2646108_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="76" mass="9021" checksum="034DE10261927A4F" modified="2011-05-03" version="1">MKSILLIRGFRGCEKFIDYYLKIHSFPKEIFLVEGEYNIIAEIEYEDYESFKKLVSELCKLHEVSKITILNVKNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIF5</accession>
    <name>F0LIF5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0200 protein TERMP_01510</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0200 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467783.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01510"/>
    <dbReference type="EnsemblBacteria" id="ADT84485">
        <property type="protein sequence ID" value="ADT84485"/>
        <property type="gene ID" value="TERMP_01510"/>
    </dbReference>
    <dbReference type="GeneID" id="10041826"/>
    <dbReference type="KEGG" id="tba:TERMP_01510"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1510"/>
    <dbReference type="eggNOG" id="arCOG01045">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096329_1_0_2"/>
    <dbReference type="OMA" id="DYMIVNE"/>
    <dbReference type="OrthoDB" id="101213at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01111">
        <property type="entry name" value="UPF0200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022970">
        <property type="entry name" value="NTP_hydrolase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="186" mass="21043" checksum="624A6C4782F866E1" modified="2011-05-03" version="1">MIICVVGMPGSGKGEVVRIFSKYGVPHVSMGDIVREEADKRGIPRTPDGMNKISIQLRQELGDNAVAKLTVPRVKELLKKHKAVIIDGVRSLDEIQTFKDAFPDQEIVIIAVHSSPKKRFERLKKRGRSDDPKTWADFEARDWKELKFGIGNVIALADYMIVNDNHIDDYRKEIEELAKKLGLAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIF8</accession>
    <name>F0LIF8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide transport ATP-binding DppF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467786.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01513"/>
    <dbReference type="EnsemblBacteria" id="ADT84488">
        <property type="protein sequence ID" value="ADT84488"/>
        <property type="gene ID" value="TERMP_01513"/>
    </dbReference>
    <dbReference type="GeneID" id="26137024"/>
    <dbReference type="KEGG" id="tba:TERMP_01513"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1513"/>
    <dbReference type="eggNOG" id="arCOG00184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="EPLRTYY"/>
    <dbReference type="OrthoDB" id="61385at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="14"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="324" mass="37028" checksum="78A2B27E1D3C141F" modified="2011-05-03" version="1">MEKVLEVKHLKKYFPVKGLFFTKGWVKAVDDISFEIYKGETFGLVGESGCGKTTTGRTILRLIEPTAGEILFEGKNVMELKGDELKWFRRKAQIMFQDPYSSLNPRQTVFEIIMEPVRFHGIEVDDPEEFVINLLKSVGLNEMHLYRYPHEFSGGQRQRIALARIMALKPEFIVLDEPTSALDVSVQANILNTLKDLQEKHGFTYLFISHDLGVVKYMSHRMGVMYLGKLVEVGPADKIFENPLHPYTQMLLSAIPVPDPEMAKELKAKRKIVRGEPPSPINPPAGCRFHPRCPFAKDVCRKEEPPMVEVEKDHHVACWLYAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIJ5</accession>
    <name>F0LIJ5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466567.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00292"/>
    <dbReference type="EnsemblBacteria" id="ADT83269">
        <property type="protein sequence ID" value="ADT83269"/>
        <property type="gene ID" value="TERMP_00292"/>
    </dbReference>
    <dbReference type="GeneID" id="10040610"/>
    <dbReference type="KEGG" id="tba:TERMP_00292"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.292"/>
    <dbReference type="eggNOG" id="arCOG08609">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_584791_0_0_2"/>
    <dbReference type="OMA" id="FAKYYSY"/>
    <dbReference type="OrthoDB" id="30674at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="478" mass="54348" checksum="F759A770D4D67026" modified="2011-05-03" version="1">MKKLGILVIILLLGVSIAYAQEVPFYKEEFVFTIKVLDNGNAQITLKTSWLEPKDEIQKQIEQILNQTNLTKEEAIKKYEKEQLDRYIASLANYGIKTTNQSLKILGIDEGKNLTVVFTAIAEKFARYYSYDGYWEIVVDPTRGYGTAPIPDTGLPYKVELHNIFIIELPQDAKLLEYPKPITREYNQSKFYVRSKVEGNKIIVTSDIYLEPYLRPEGFKALFGDYNTFYVRYTTPKPGEEGQYQKVVSEWYLRAEVLPNGTTNLFIKDTYIEPKDQVELRKLQIKLMGVQNVTDLILQNNIKALGGQGIKVENANAKIIGLNETGPLIIEANYVVQNFTKKVNGTYEYSFDPTLGYSLYNIGYRAQNEINQTLKLELILPTDAKIVEVPQNITRELKGNRFTLTTLVNGNKISITANVFIRYGAHQEDVQKLLANISRAYIRFTLPEASQGLNYKQVGAAVGALVLIGAAVFLIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIK2</accession>
    <name>F0LIK2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Putative snRNP Sm-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466574.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00299"/>
    <dbReference type="EnsemblBacteria" id="ADT83276">
        <property type="protein sequence ID" value="ADT83276"/>
        <property type="gene ID" value="TERMP_00299"/>
    </dbReference>
    <dbReference type="GeneID" id="26135640"/>
    <dbReference type="KEGG" id="tba:TERMP_00299"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.299"/>
    <dbReference type="eggNOG" id="arCOG00998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_11_1_2"/>
    <dbReference type="OMA" id="GYDVHMN"/>
    <dbReference type="OrthoDB" id="119206at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01731">
        <property type="entry name" value="archaeal_Sm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00257">
        <property type="entry name" value="Lsm_RuxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022901">
        <property type="entry name" value="snRNP_Sm-like_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="PTHR10553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="4">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="76" mass="8458" checksum="AD894B0F5C603816" modified="2011-05-03" version="1">MAERPLDVIHRSLDKDVLVILKKGFEFRGKLIGYDIHLNVVLADAQLIEGGEVTKKYGKIVIRGDNVLAISPVETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIN4</accession>
    <name>F0LIN4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TldD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466606.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00331"/>
    <dbReference type="EnsemblBacteria" id="ADT83308">
        <property type="protein sequence ID" value="ADT83308"/>
        <property type="gene ID" value="TERMP_00331"/>
    </dbReference>
    <dbReference type="GeneID" id="10040649"/>
    <dbReference type="KEGG" id="tba:TERMP_00331"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.331"/>
    <dbReference type="eggNOG" id="arCOG00321">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_2_2"/>
    <dbReference type="OMA" id="IRVGHAS"/>
    <dbReference type="OrthoDB" id="22382at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="114"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="232"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="472" mass="53380" checksum="27205A8343C06835" modified="2011-05-03" version="1">MHELVEFAVEKALELGAEYAEARFEEHSGVNIVMKNGNPEGVGIRADRGIGVRVLVNGGMGFASTNVLRKESVNEAVKKAVKLAKAASKVRNIPIKFSEERFHEVYYEVRMKKDFRDYSGEEKMEYLRLIEEEVLNSGIKVPMRFLSYQDWIAHKYFVNNEGAKVESVIPRVSITYNLVVFEEGQVEQAPFVQTAFTGGLELIERAEPWKKALNDVKALQRLIKEGKKPPEGKVDVVISPEVAGIAVHESVGHPYEADRIFGREAAQAGESFVKPDMLGERIGSEAVTVIEDPTIPNSWGFYLYDDEGIKARPRYLIKDGIITEFLMNREYAYYLDTNSNAAARAINYDREPIVRMANTYLAPGDYSFEELIEDVKLGVYMVSFNEWNIDDRRYQQRYIGREAYLIENGEIKHPVRRPILEITTKGLWSSVDAVGKEVEFYPGTCGKGEPGQGVPVWMGGASARLRDVVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIN7</accession>
    <name>F0LIN7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glyceraldehyde 3-phosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466609.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00334"/>
    <dbReference type="EnsemblBacteria" id="ADT83311">
        <property type="protein sequence ID" value="ADT83311"/>
        <property type="gene ID" value="TERMP_00334"/>
    </dbReference>
    <dbReference type="GeneID" id="10040652"/>
    <dbReference type="KEGG" id="tba:TERMP_00334"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.334"/>
    <dbReference type="eggNOG" id="arCOG02291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_3_2"/>
    <dbReference type="OMA" id="LCENLQD"/>
    <dbReference type="OrthoDB" id="93004at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011950">
        <property type="entry name" value="HAD-SF_hydro_IA_CTE7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02253">
        <property type="entry name" value="CTE7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="242" mass="28427" checksum="F64BFA73C39E821E" modified="2011-05-03" version="1">MIKVVFFDLDDTIADTTRLAEMARKNAIENMIRHGMPVDFDTAYNELLELINEYGSNFPRHFDYLLRRLDLRYNPKWVAAGVIAYHNTKFAYLREVRHVRKTLLKLREMGLRLGIITDGDPIKQWEKILRLDLDDFFEHVVISDFEGVKKPHPKIFQKALRIFGVKAQEAVMVGDRLYSDIYGAKSVGMHTVWFRYGKYANREEEYREYADHEITDLLDVLKIIEVLNSGKDDSNKKVHADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIS6</accession>
    <name>F0LIS6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467826.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01553"/>
    <dbReference type="EnsemblBacteria" id="ADT84528">
        <property type="protein sequence ID" value="ADT84528"/>
        <property type="gene ID" value="TERMP_01553"/>
    </dbReference>
    <dbReference type="GeneID" id="10041869"/>
    <dbReference type="KEGG" id="tba:TERMP_01553"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1553"/>
    <dbReference type="eggNOG" id="arCOG00585">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_2"/>
    <dbReference type="OMA" id="NMAYFTP"/>
    <dbReference type="OrthoDB" id="32313at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="292" mass="31937" checksum="6217BD3C7BA7E600" modified="2011-05-03" version="1">MTIKTPPSLNIPGFGVDPLTQRIKEKEKKWKYKVAVLSGKGGVGKSTVAVNLATALAKLGYFVGVLDADVHGPNVAKMFGVEKAEILAEKVNDHFEMIPPVVDFMGQVTPIKVMSMGMMVPEDQPIIWRGALVTKALKQLLGDVKWGELDFMIIDFPPGTGDQILTVTQTLKLDAAIVVTTPQEVALLDTGKAVNMMKQMEVPYIAVIENMSYLICPHCGNKIDLFGEGGGEKLAKKENVDFLGKIPIDPKAREASDLGIPIVLYDDTPAAKAFMEITQRLVEKLEEMKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIU9</accession>
    <name>F0LIU9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01576"/>
    <dbReference type="EnsemblBacteria" id="ADT84551">
        <property type="protein sequence ID" value="ADT84551"/>
        <property type="gene ID" value="TERMP_01576"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01576"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1576"/>
    <dbReference type="eggNOG" id="arCOG09833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3148167_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="49" mass="5813" checksum="D4085D06C3D1CCE5" modified="2011-05-03" version="1">MLREIKKELVEYISRNTGIDKDTVVKVLRAEEAFFMMQIRKALEKEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIW6</accession>
    <name>F0LIW6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type I restriction-modification system specificity subunit S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01593</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467866.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01593"/>
    <dbReference type="REBASE" id="29886">
        <property type="entry name" value="S.TbaMPORF1595P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84568">
        <property type="protein sequence ID" value="ADT84568"/>
        <property type="gene ID" value="TERMP_01593"/>
    </dbReference>
    <dbReference type="GeneID" id="10041909"/>
    <dbReference type="KEGG" id="tba:TERMP_01593"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1593"/>
    <dbReference type="eggNOG" id="arCOG02626">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021095_10_1_2"/>
    <dbReference type="OMA" id="PEDWEVK"/>
    <dbReference type="OrthoDB" id="102840at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="14"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="211"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="408" mass="47217" checksum="72C2CFF6D723ADB2" modified="2011-05-03" version="1">MHAKFKKTPIGEIPEDWQVVKLGKIIGYTKGKKPKMVAKEPKDGWLPYLSTEYLRNNNPTQFVKITGNEIIVEDGDILLLWDGSNAGEFFLAKKGVLSSTMVKIFLKKHVYDSLFLFYLLKHREPFLKGQTKGTGIPHVDKNVLNALLLPLPPLEEQKQIAEILRTVDEAIEKTDLAIEKTERLKKGLMQRLLTKGIKHKRFKKTEIGEIPEEWRVVRIGEVTGLFQYGLSIKMHDKGKYPIIKMDSIINGEVKPVNIKYVDLDEDTFKKYRLEKGDILINRTNSYELVGRTGVFMLDGDYVFASYLIRIRPDKKQIDPRFLTFYLIFANDKLRQLATRAVSQANINASNLKKFKIPLPPLEEQKQIAEILMTVDKKLELLRKRKEKLERIKRGLMKDLLTGRRRVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ35</accession>
    <name>F0LJ35_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase</fullName>
            <shortName evidence="6">TDH</shortName>
            <ecNumber evidence="6">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tdh</name>
        <name evidence="8" type="ordered locus">TERMP_00404</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466679.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00404"/>
    <dbReference type="EnsemblBacteria" id="ADT83381">
        <property type="protein sequence ID" value="ADT83381"/>
        <property type="gene ID" value="TERMP_00404"/>
    </dbReference>
    <dbReference type="GeneID" id="10040722"/>
    <dbReference type="KEGG" id="tba:TERMP_00404"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.404"/>
    <dbReference type="eggNOG" id="arCOG01459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_2"/>
    <dbReference type="OMA" id="GVFHNTP"/>
    <dbReference type="OrthoDB" id="67758at2157"/>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00627">
        <property type="entry name" value="Thr_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004627">
        <property type="entry name" value="L-Threonine_3-DHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00692">
        <property type="entry name" value="tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="7">
        <location>
            <begin position="16"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="266"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="291"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom" evidence="6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="350" mass="38222" checksum="C3212A364F32C0C3" modified="2011-05-03" version="1">MADKMIAIMKSKPAYGAELVEVDVPKPKEGEVLIKVLATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEDIQVGDYISAETHIVCGKCYQCRTGNYHVCQNTKIFGVDTDGVFAEYAIVPAQNAWKNPKNIPPEYATLQEPLGNAVDTVLAEPVAGKTVLITGAGPLGLLGITVAKAAGASLVIVSEPSDFRRELARKVGADVVINPFEEDVVKEVRDLTDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLFPRDVSIDFNNLIIFKSLTVYGITGRHLWQTWYTVSRLLQSGKLNLDPIITHKYKGFDKFEEAFELMRAGKTGKVVFFPHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ77</accession>
    <name>F0LJ77_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467897.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01624"/>
    <dbReference type="EnsemblBacteria" id="ADT84599">
        <property type="protein sequence ID" value="ADT84599"/>
        <property type="gene ID" value="TERMP_01624"/>
    </dbReference>
    <dbReference type="GeneID" id="10041940"/>
    <dbReference type="KEGG" id="tba:TERMP_01624"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1624"/>
    <dbReference type="eggNOG" id="arCOG02291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_3_2"/>
    <dbReference type="OMA" id="GNVMFWP"/>
    <dbReference type="OrthoDB" id="93004at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="230" mass="26353" checksum="B4589C1868ECCABD" modified="2011-05-03" version="1">MKLVSFDVWNTLLDINVMLEELTKALAELTKKDYKEVFEKVMEARGEIKELRKSKRGNPEKALEESQEILAKKLGCDIEIIKRVAAKATLRVDERIVIEGAIEGLKAAKEKDLIIITTGNVMFWPSAYTRLILERFGLADFIDRQFYSDELKAYKPMKEVFLKPLEYFGVKPEEALHIGDTYAEDFEGALNAGLWAVWINPDAEKVERIAERGFVVRNAGELEEVLKLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ95</accession>
    <name>F0LJ95_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84617">
        <property type="protein sequence ID" value="ADT84617"/>
        <property type="gene ID" value="TERMP_01642"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01642"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1642"/>
    <dbReference type="HOGENOM" id="CLU_2597924_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="79" mass="8863" checksum="8D554F8975E70287" modified="2011-05-03" version="1">MYGYAKFAVSRVKVLEEKGDYLLLAVEPHGHMIKANVYVLILLLTVPGFKKTLFRLLGEEGESEDENECGIIDSSYLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJB9</accession>
    <name>F0LJB9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LSU methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467939.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01666"/>
    <dbReference type="EnsemblBacteria" id="ADT84641">
        <property type="protein sequence ID" value="ADT84641"/>
        <property type="gene ID" value="TERMP_01666"/>
    </dbReference>
    <dbReference type="GeneID" id="10041982"/>
    <dbReference type="KEGG" id="tba:TERMP_01666"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1665"/>
    <dbReference type="eggNOG" id="arCOG00032">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014042_0_0_2"/>
    <dbReference type="OMA" id="VMDVFDY"/>
    <dbReference type="OrthoDB" id="59984at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="396" mass="44929" checksum="881D3D67B3951039" modified="2011-05-03" version="1">MARVYVDAQASRALQKGAMIIFKKGVVRTEGEIKPGDIVEVYSRGGKFLGKGFANPNSNIMVRLLTKEKDVEINKELFKERIRKANEYRKKVLRYGNVYRMVYGEADYLPGLIVDRFNDIAAIQISSAGMERFKLDVAEAIMEVEPDIETVFEKNTGRSRRREGLPEIERVLLGKEKYRTIIEEGKAKFIVDMRGQKTGFFLDQRENRIALEKYIRGGEKVLDVFTYTGGFAIHAAVAGAEKVIAIDKSPRAIEQAKENAKLNGVEDKMEFIVGSAFPEMEKLQKRGEKFDIVILDPPAFVQHEKDLKRGLRAYFNVNYQGLKLVKDGGILVTCSCSQHVDLQAFKDMIIAAAAKAGKFLRMLEPYRTQAPDHPILMASKDTEYLKCLFLYVEDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJG7</accession>
    <name>F0LJG7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation initiation factor 2B alpha/beta/delta-type subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466731.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00456"/>
    <dbReference type="EnsemblBacteria" id="ADT83433">
        <property type="protein sequence ID" value="ADT83433"/>
        <property type="gene ID" value="TERMP_00456"/>
    </dbReference>
    <dbReference type="GeneID" id="10040774"/>
    <dbReference type="KEGG" id="tba:TERMP_00456"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.456"/>
    <dbReference type="eggNOG" id="arCOG01125">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_2_1_2"/>
    <dbReference type="OrthoDB" id="36100at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="275" mass="30977" checksum="CA7AFA3946DD0E38" modified="2011-05-03" version="1">MLPREVQAIIEEMKAERIRGASYLAKRGAEAYLKLAEVLTGEELFEALKEMRNEIISVNPTMASLYNLVRFIPLTNNPEFIRAKAEEFIKLSEEAKREIGNIGSELIDENEVIITHSFSSTVFEILKAAKMKGKRFKVILTESAPDYEGLALAKELEKLDISFEVITDAQLGLFAKKATLALVGADNITRDGCVINKAGTYLLALACHDNAVPFYVAAESFKVHPELKADDVEIVERKFKRNHFLIRNYLFDITPWKYVRGIITELGILVPPKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJI0</accession>
    <name>F0LJI0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted zinc-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466744.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00469"/>
    <dbReference type="EnsemblBacteria" id="ADT83446">
        <property type="protein sequence ID" value="ADT83446"/>
        <property type="gene ID" value="TERMP_00469"/>
    </dbReference>
    <dbReference type="GeneID" id="10040787"/>
    <dbReference type="KEGG" id="tba:TERMP_00469"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.469"/>
    <dbReference type="eggNOG" id="arCOG00458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072985_0_0_2"/>
    <dbReference type="OMA" id="DCVMNPP"/>
    <dbReference type="OrthoDB" id="73920at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11375">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012962">
        <property type="entry name" value="Pept_M54_archaemetzincn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910">
        <property type="entry name" value="PTHR15910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07998">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="250" mass="28928" checksum="F6363239E5D2214B" modified="2011-05-03" version="1">MKTVWFVYIGNNSYRDVVFYAYTDVNKYLAENNIPIRLIFHHPRVRAGENAENMPEKDIILESKPGFTITINTGKGKVVAYPLEGILDVLYGWLVKTRHEVQEIYEMHQIEPDDEIPDTVIGVVSFPLVTRNPYLDFYEKFLGIQKKVSGLNIIAVSVSPFYHPNKLKFSNRIFKAILHELGHAFGLDHCSENCVMNPPSTIEEWDSRVPDFCPKCFLELKRNVEWKENKRDNTSLQRGEEDRESSSKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJI9</accession>
    <name>F0LJI9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas1</name>
        <name evidence="10" type="ordered locus">TERMP_00478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466753.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00478"/>
    <dbReference type="EnsemblBacteria" id="ADT83455">
        <property type="protein sequence ID" value="ADT83455"/>
        <property type="gene ID" value="TERMP_00478"/>
    </dbReference>
    <dbReference type="GeneID" id="10040796"/>
    <dbReference type="KEGG" id="tba:TERMP_00478"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.478"/>
    <dbReference type="eggNOG" id="arCOG01452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052779_2_0_2"/>
    <dbReference type="OMA" id="AYKLIKH"/>
    <dbReference type="OrthoDB" id="70037at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09722">
        <property type="entry name" value="Cas1_I-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019858">
        <property type="entry name" value="CRISPR-assoc_Cas1_HMARI/TNEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43219">
        <property type="entry name" value="PTHR43219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03641">
        <property type="entry name" value="cas1_HMARI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="322" mass="37769" checksum="03174F64614C6636" modified="2011-05-03" version="1">MRKKPLTLFSDGTLYRKENTLYFENAQGKKPLAIEGIYDIYIYGKVTITSQALHFLAQKGIAVHFFNHYGYYDGSFYPRESLHSGDLVIKQAEHYLDREKRLRLAKLFVKGAAKNMERNLKRWGVNTSFGELLEELDDARKITDIMNIEARIRQEYYALWDETLPDGFKIVKRTRRPPQNEMNALISFLNSRLYPAIISELYNTQLTPTISYLHEPSERRFSLALDLSEIFKPIIADRIANRLVKQGIIKKEHFRDDLNGVLLNDEGKKIVLKAFNEEMRKSVKHPKLKRNVTKQRLIRLEAYKLIKHLIGSQEYEPLVAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJJ9</accession>
    <name>F0LJJ9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466763.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00488"/>
    <dbReference type="EnsemblBacteria" id="ADT83465">
        <property type="protein sequence ID" value="ADT83465"/>
        <property type="gene ID" value="TERMP_00488"/>
    </dbReference>
    <dbReference type="GeneID" id="10040806"/>
    <dbReference type="KEGG" id="tba:TERMP_00488"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.488"/>
    <dbReference type="eggNOG" id="arCOG00908">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1297533_0_0_2"/>
    <dbReference type="OMA" id="EYKEDKF"/>
    <dbReference type="OrthoDB" id="82144at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019202">
        <property type="entry name" value="DUF2067"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09840">
        <property type="entry name" value="DUF2067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="209" mass="24407" checksum="FE9F60BF5BEB6430" modified="2011-05-03" version="1">MKAKKVIVIHVRDDVEKEEFMRELQKLNLPAFIYVHGKLNSLKINIQGTKDEIRDAIYKIKDIHKRVRSRLYANKRGLYRYVLDDIFREAGVSISAPILLKTLELLGETVEFKDNELETSMPWNEIVNLTRKLGEYLADISLQTTRQIREVALPLAIVFDIDPEEVLDLMVEVGVAEYKEDKFKYELVKNKEQAMEIMLKHLTGEEDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJK0</accession>
    <name>F0LJK0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component Csl4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">csl4</name>
        <name evidence="6" type="ordered locus">TERMP_00489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CSL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466764.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00489"/>
    <dbReference type="EnsemblBacteria" id="ADT83466">
        <property type="protein sequence ID" value="ADT83466"/>
        <property type="gene ID" value="TERMP_00489"/>
    </dbReference>
    <dbReference type="GeneID" id="10040807"/>
    <dbReference type="KEGG" id="tba:TERMP_00489"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.489"/>
    <dbReference type="eggNOG" id="arCOG00676">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067135_1_1_2"/>
    <dbReference type="OMA" id="CGNVETR"/>
    <dbReference type="OrthoDB" id="111542at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00975">
        <property type="entry name" value="Exosome_Csl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030850">
        <property type="entry name" value="Exosome_Csl4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="PTHR12686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="74"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="200" mass="22262" checksum="3E6CFE411CD1EDA4" modified="2011-05-03" version="1">MDVENRKKKSVKNGDFVLPGDYLGVIEEFLPGDGVIEENGELYSTRAGKVKINQEKMEISVVPVTDTPPIPKVGQIVIAKVIEVKPQAAIVQLLRIEGREDYREIATSKLAGIHISQVKEGFVEDMSKEFKIGDIVRARVLTDEKSPIQLTTRAPDLGVVFALCSNCKTPLVRRGNQLICPKCGRIETRKLSAFYRKIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJN8</accession>
    <name>F0LJN8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secF</name>
        <name evidence="11" type="ordered locus">TERMP_01705</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the protein translocation apparatus. Forms a complex with SecD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467978.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01705"/>
    <dbReference type="EnsemblBacteria" id="ADT84680">
        <property type="protein sequence ID" value="ADT84680"/>
        <property type="gene ID" value="TERMP_01705"/>
    </dbReference>
    <dbReference type="GeneID" id="10042021"/>
    <dbReference type="KEGG" id="tba:TERMP_01705"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1704"/>
    <dbReference type="eggNOG" id="arCOG03054">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060478_0_0_2"/>
    <dbReference type="OMA" id="DLMNTYL"/>
    <dbReference type="OrthoDB" id="63405at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_A">
        <property type="entry name" value="SecF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024921">
        <property type="entry name" value="SecF_arc"/>
    </dbReference>
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        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
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        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT84680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="308" mass="33935" checksum="633ABBC2E58B9144" modified="2011-05-03" version="1">MIKDKLKKLTEIETKKMIVYPLVVFFVALLILAVHFPQLGIDLKGGVVVTAYGVDANPDEVAKYLSQQLGVDVRVEKFTGIGKESSGINVYAPAEVDPEKIREALRQLFPNAKYAISEVRPTFGAMAREQGIKAISLAFLGMAIVVFLFFRVPVPSFTVIFSAFSDMVIALALMSIFGIELSQATIAALLMLIGYSVDSNILLTTKLLKRKEDTVEEAYFSAVSTGFTMSTTTLGALASLWLFSTAKVIDEIAIVLIFGLLADFMNTWILNAGVLRWFIAKKEEREKRKSSGTSKASKASKKKRRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJQ2</accession>
    <name>F0LJQ2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01719"/>
    <dbReference type="EnsemblBacteria" id="ADT84694">
        <property type="protein sequence ID" value="ADT84694"/>
        <property type="gene ID" value="TERMP_01719"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01719"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1718"/>
    <dbReference type="eggNOG" id="arCOG11266">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_219596_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="39" mass="5047" checksum="D1E6862E860DAAC8" modified="2011-05-03" version="1">MGLKEFFAEWRRRCPFIRAIEKWRFERKKNKFEVKRKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJR3</accession>
    <name>F0LJR3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium efflux system KefA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01730"/>
    <dbReference type="EnsemblBacteria" id="ADT84705">
        <property type="protein sequence ID" value="ADT84705"/>
        <property type="gene ID" value="TERMP_01730"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01730"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1729"/>
    <dbReference type="eggNOG" id="arCOG05757">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06529">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073775_0_0_2"/>
    <dbReference type="OMA" id="WIDAVNS"/>
    <dbReference type="OrthoDB" id="73553at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024981">
        <property type="entry name" value="DUF3887"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13026">
        <property type="entry name" value="DUF3887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3887" evidence="2">
        <location>
            <begin position="27"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="365" mass="40621" checksum="2428C000F3A06F33" modified="2011-05-03" version="1">MRKVALIFIITMLAFYALAQQPYDEVAKAVFESLKTGNYSILEPYLDENMKEAFNEKSFNALREQMISKYGGLKSFEFIEEGKSGKFALAYYRFQFEKANVTLRLVFSQTNGEYKLSGLWIQKVVWREKGIPLPLAVGLPILGGILALLTFYTLGFKKIKGAELILGFFLVAITLFIQPVIQQAPFLALGIKSNADITAKGFAFTAITAIWLGFIAGFFQEGLKYAFMRNKRLKEALFVGIGFGLGEAILVPLLQVVQSFILGGLTVQLTQALLSLFERYIATLFHGGTTITLAYAYKNGFGRKALVVLSIVHGAIDTFASYYQLTNSQISLIMTYGTITAITLILLWYAIPKAKVEGEEGKVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJT4</accession>
    <name>F0LJT4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468023.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01751"/>
    <dbReference type="EnsemblBacteria" id="ADT84726">
        <property type="protein sequence ID" value="ADT84726"/>
        <property type="gene ID" value="TERMP_01751"/>
    </dbReference>
    <dbReference type="GeneID" id="26137264"/>
    <dbReference type="KEGG" id="tba:TERMP_01751"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1750"/>
    <dbReference type="eggNOG" id="arCOG05087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117658_0_0_2"/>
    <dbReference type="OMA" id="IKMRHIP"/>
    <dbReference type="OrthoDB" id="84048at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015207">
        <property type="entry name" value="DUF1931"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09123">
        <property type="entry name" value="DUF1931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="153" mass="17579" checksum="CF65B8A54C251C03" modified="2011-05-03" version="1">MAEMIIPYPQLQKILERTCELAVIKPRAEEMMEIVEKKLSDLFEVAYENAKAENTGIIRLRHLPLTKGFKNSMNLFRAVIEDEKVEIEPIRKFVLKKIPSDLPLDEEVVNELPIITGTLFVLVGRVIKALHPEVKNVYPEHIEEAGKVLDYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJT9</accession>
    <name>F0LJT9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Type 2 DNA topoisomerase 6 subunit B</fullName>
            <ecNumber evidence="1">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Type II DNA topoisomerase VI subunit B</fullName>
            <shortName evidence="1">TopoVI-B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">top6B</name>
        <name evidence="3" type="ordered locus">TERMP_00499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TOP6B family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466774.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00499"/>
    <dbReference type="EnsemblBacteria" id="ADT83476">
        <property type="protein sequence ID" value="ADT83476"/>
        <property type="gene ID" value="TERMP_00499"/>
    </dbReference>
    <dbReference type="GeneID" id="10040817"/>
    <dbReference type="KEGG" id="tba:TERMP_00499"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.499"/>
    <dbReference type="eggNOG" id="arCOG01165">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006403_0_0_2"/>
    <dbReference type="OMA" id="TRIELEM"/>
    <dbReference type="OrthoDB" id="13565at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00823">
        <property type="entry name" value="TopoIIB_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00322">
        <property type="entry name" value="Top6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005734">
        <property type="entry name" value="TopoVI_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015320">
        <property type="entry name" value="TopoVI_B_transducer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF4">
        <property type="entry name" value="PTHR10871:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09239">
        <property type="entry name" value="Topo-VIb_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006553">
        <property type="entry name" value="TopoVI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01052">
        <property type="entry name" value="top6b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="31"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="570" mass="64758" checksum="705C99A4302D669D" modified="2011-05-03" version="1">MAKAKELFKEFKIQSVSEFFRRNAAMLGYTGKIRSLTTVVHEAVTNSLDACEEAGILPYVRVEIEELGREHYKIIVEDNGPGIPEKFITHVFGKMLAGTKAHRNIQSRGQQGIGISGAVMFAQITSGKATRVITSTGGDEIIEAWVKIDVEKNEGKIVKKIKHPNPTGWRGTRIELEVKNVKYVRSKQGVFWYLKLTAIANPHAHIELIEPDGKLIVFPRSSEEVPKPPVEMKPHPRGVMTDDVYRMAKRTRKNTVKRFLISEFSRISDRKIDELIKYIAAIRLINSEEDKRIKDELFERLAKGEVDLILRSYGRRAKKAIREVQKLMDKPPEKLTWHEAEEIVEAFKYIKFLAPPTHGLRPIGEENIVKGLTGILKPEFVTAVTRPPKVYRGGIPFQVEIGLAYGGELESSFNLLRYANRVPLLFDAGACVTTTAARSIDWKRYKVEDLDRAPLTLLINVISVHVPYTSTGKQSIANEDEIYEEIRLAIMEAARRLQTYLSGKHRKLYQVKRKKTLQKYVPEIARALSILTGEPEEKVKEYFISLIERKFEAVEEALEQPAEVEADAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJU3</accession>
    <name>F0LJU3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="4">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsY</name>
        <name evidence="6" type="ordered locus">TERMP_00503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466778.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00503"/>
    <dbReference type="EnsemblBacteria" id="ADT83480">
        <property type="protein sequence ID" value="ADT83480"/>
        <property type="gene ID" value="TERMP_00503"/>
    </dbReference>
    <dbReference type="GeneID" id="10040821"/>
    <dbReference type="KEGG" id="tba:TERMP_00503"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.503"/>
    <dbReference type="eggNOG" id="arCOG01227">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_3_1_2"/>
    <dbReference type="OMA" id="GISDQFQ"/>
    <dbReference type="OrthoDB" id="90641at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="5">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="111"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="193"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="251"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="300" mass="33131" checksum="EB6E3B197C28BE2C" modified="2011-05-03" version="1">MFGKLKEKLSSFVDKVAQTEIKEKDVEEALWDLELELLEADVALEVVEELKEKIKQQLVGQKVKIGTDKKKIVEDAVRKAVLEVLTPERKINLLEMIKAKKEKPFVIVFVGFNGSGKTTTIAKLAHWLKKHGLSSVIAASDTFRAGAIEQVEEHARRVGVKVIKHRYGADPAAVAYDAIQHAKARGVDVVLVDTAGRNELNRNLMDEMKKIVRVTKPDLVIFVGDALAGNAIIEQARQFNEAVKIDGVILTKLDADARGGAALSISHAIGAPILFVGIGQGYDDLKEFDEKWMIEKIFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK32</accession>
    <name>F0LK32_THEBM</name>
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        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01769"/>
    <dbReference type="EnsemblBacteria" id="ADT84744">
        <property type="protein sequence ID" value="ADT84744"/>
        <property type="gene ID" value="TERMP_01769"/>
    </dbReference>
    <dbReference type="GeneID" id="26137283"/>
    <dbReference type="KEGG" id="tba:TERMP_01769"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1768"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_3_0_2"/>
    <dbReference type="OMA" id="FQILIRA"/>
    <dbReference type="OrthoDB" id="97695at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="164" mass="18843" checksum="A7CA3B0FDCFD4D6A" modified="2011-05-03" version="1">MASIDEKDEEILKELRKNGRATLTELGRKIGLSPASIKNRIEKLESLGAIKGYSAIVDPAFLNEFIQAIIEVELLVDNEAVDRMLYNISRLDNVIGVYRKTGEFQILIRANFKDVPQLKEFVKSLSVKYLGKNMKRAKVSVIMDTFKEGGVIMQERKTRRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK34</accession>
    <name>F0LK34_THEBM</name>
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        <submittedName>
            <fullName evidence="2">Putative carbohydrate binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">TERMP_01771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT84746">
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        <property type="gene ID" value="TERMP_01771"/>
    </dbReference>
    <dbReference type="GeneID" id="10042087"/>
    <dbReference type="KEGG" id="tba:TERMP_01771"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1770"/>
    <dbReference type="eggNOG" id="arCOG02994">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116722_4_1_2"/>
    <dbReference type="OMA" id="DWEHEIF"/>
    <dbReference type="OrthoDB" id="105481at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="41"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="123" mass="14113" checksum="760CFE58740D88B5" modified="2011-05-03" version="1">MFVGHYLDVEEKEVTIEGVEKTTIRWLISPKIGAKNFAMRYFVIKKGGKIPTHQHPWEHEIFVIKGEGYITNGRKTVKVVPGSFLYIPPNEPHAYENPDSETFEFLCIIPVTEKSIPPEERGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK54</accession>
    <name>F0LK54_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-layer-like array protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468062.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84766">
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        <property type="gene ID" value="TERMP_01791"/>
    </dbReference>
    <dbReference type="GeneID" id="10042107"/>
    <dbReference type="KEGG" id="tba:TERMP_01791"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1790"/>
    <dbReference type="eggNOG" id="arCOG03264">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_649925_0_0_2"/>
    <dbReference type="OMA" id="WVIRISS"/>
    <dbReference type="OrthoDB" id="43047at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEGA" evidence="1">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="1">
        <location>
            <begin position="358"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="425" mass="48547" checksum="2FE2EE36A6B292A6" modified="2011-05-03" version="1">MFRKEHVFTALIMFLLTISAFSSVSAFGNENIVLQIDSRPSNATVIIQGINKTFKTPAVIELPSKNWVIRISSGNYTVLYNLVPPEDERFVKIVVYFGRIDLAVKGPFKNITVEYGFNSTVPTKEDEYVPPIAAPFWDEEVCGGIIMFGPKNPPMVIYKYDNKDPYYQLFLNSTPSIEEYRGRKGCKMIEMIYYFGNESAMARGFPYREASFIVPYSLLSIDSQPKNATVYIFDFHRFGEWFTPFDALVPVVMEPQRNVSLIHYDLELGNLTTTVIPYIPELHTYKISMGHNGYPFLEGWLELKPNQSYNIRVNFNILRSALTVNGKEVEMQVPKTKKTTYYLPNTTLLIINSTIALDVYIDGSYVGKTPFKDEVPSGEHDILLKFGSYVVYHKKLDIGYGGRFRLTVIPVKLLKILNVPKIRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK56</accession>
    <name>F0LK56_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoserine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01793"/>
    <dbReference type="EnsemblBacteria" id="ADT84768">
        <property type="protein sequence ID" value="ADT84768"/>
        <property type="gene ID" value="TERMP_01793"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01793"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1792"/>
    <dbReference type="eggNOG" id="arCOG01159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_926284_0_0_2"/>
    <dbReference type="OMA" id="DESQACH"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="PTHR31027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="313" mass="38162" checksum="B2D6B5DACBDBC1B2" modified="2011-05-03" version="1">MSNYSKIGEGEDTMQVKVDPEEIKRIKAEIEALEKEKREIQAKLEELQKELNIWIQKRDEKNNEVKQLRQKAREYKQKRDEVNKQIQELKKNREDINAKLDLLYQEILEYRTKRDEYNQLRRLRMPKEKIEERIDKLEWELQTNPNITPEREKQIVDQIQVLATELEIIQQAERFHQKLQETRKKVESLKKARRAISLEIQKLANQSQQFHEQMIKAYQQADEIKKEADEYHQKVVELREKIREVRRQLREIERKIMEYDEKHKELIAYKLVARMRAKRDATFEKAVEALEKFKRGEKLTLDEILLLQRYNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKD4</accession>
    <name>F0LKD4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoglutarate oxidoreductase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466890.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00615"/>
    <dbReference type="EnsemblBacteria" id="ADT83592">
        <property type="protein sequence ID" value="ADT83592"/>
        <property type="gene ID" value="TERMP_00615"/>
    </dbReference>
    <dbReference type="GeneID" id="26135844"/>
    <dbReference type="KEGG" id="tba:TERMP_00615"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.617"/>
    <dbReference type="eggNOG" id="arCOG01599">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_2_0_2"/>
    <dbReference type="OMA" id="LPTIFCP"/>
    <dbReference type="OrthoDB" id="43666at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="56"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="281" mass="31293" checksum="83F42C5E042E88A9" modified="2011-05-03" version="1">MYLKLSYEIRDKYLRKDMLPTIFCPGCGIGSVLQYTLRAIDELGWSKDDVVWVSGIGCSSRVPGFVDFDGLHTTHGRALAFATGIKMANPDLKVIAFMGDGDTAAIGGNHFIHAIRRNLDVTVILINNFTYGMTGGQVAPTTLKGLRGTTAPYGSFENPFDIAELAVAAGANYVARWTVFNYLQGINSIKKALQKKGFSLVEFLSPCPISFGRRNRMKTAPELIKWYNKITVPISKAKNMSPEELKGKIIIGEFVDRDRPSLDEEYEAYKKRAKKMMGWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKD9</accession>
    <name>F0LKD9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466895.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00620"/>
    <dbReference type="EnsemblBacteria" id="ADT83597">
        <property type="protein sequence ID" value="ADT83597"/>
        <property type="gene ID" value="TERMP_00620"/>
    </dbReference>
    <dbReference type="GeneID" id="10042543"/>
    <dbReference type="KEGG" id="tba:TERMP_00620"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.622"/>
    <dbReference type="eggNOG" id="arCOG13735">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_403693_0_0_2"/>
    <dbReference type="OMA" id="STHAGLI"/>
    <dbReference type="OrthoDB" id="15956at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="682" mass="77482" checksum="35A0AA5DE07DC1A5" modified="2011-05-03" version="1">MRRIHISLFLLMIMILTALPPTHAEVVALVKNPRPPVIIVGNLYPKFLTVSPNTSYTVYLYGIDDVGIVKMGIYYRVNRGNWKWLYASEATVNENETMYNIITSRFLTQKFNFTTFYGKATIPPQPPGSLVEFKAVIEDKEGNIVESPVGIYFVPNPGGKKILIVDPSLKLWGMVQNLKDLDLMVNLSFERYHYNMSDYKDVLSLLRPFGKHSDFLSFHSWQYLADEYNIAVITSNELSSALEEFKPDVIILSNLWMKEWEISRKDIDKLLRYLRINNAGLIVTHGTLYDGTVFKNKLIKLGSSKHIGGFEAYKNGSIATALGLELLPFIEEVKLKAVELGKSYLSEIPSILPFIPSSAKIGIKNREIIKSTSLLEFTNETRTAFGWQYLLPPKSLKFAKDRIRSLKLDVKDDIKEFAELQEELFGNSNYLKSVSALDFTLIDKIIDSKILDDKISIPVGFKTLNLTASQEIIERIRLLKAINPDIVDIVALSTDYMGAIITRDQNHRGDGFRSAYVSFEIEAGGRKEFKVLKDLIEWSSEFRPIKTFAPIVQTVILANDIDWEIKGKELKKSLESFGVMVIRAKPQEFGKLKSSRFIIILGGPKAYDGVGKYVQQALSLEEQEKIIKGEQGIFIKRNVWTEKQIVIILAGKDRNQTGEKVSKYLSGVNEEYIDLLAEFFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKF3</accession>
    <name>F0LKF3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Archaeal ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466909.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00634"/>
    <dbReference type="EnsemblBacteria" id="ADT83611">
        <property type="protein sequence ID" value="ADT83611"/>
        <property type="gene ID" value="TERMP_00634"/>
    </dbReference>
    <dbReference type="GeneID" id="10040952"/>
    <dbReference type="KEGG" id="tba:TERMP_00634"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.636"/>
    <dbReference type="eggNOG" id="arCOG03166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041137_3_0_2"/>
    <dbReference type="OMA" id="RNYFAIM"/>
    <dbReference type="OrthoDB" id="21452at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="243"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="310"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="460" mass="54838" checksum="B069A6780537F3FE" modified="2011-05-03" version="1">MFIDRETEMKLLEERLKRGKAEFIVVYGRRRIGKTALLLEFIKKHGGVYLLARETSESENLKRFSEKLAEYFNDEFLRKNPLQSWDAFFEYLHQKSLKDRLIIVIDEFPYLVKGNKVLPSILQEYWDLKLSQGKIFLIICGSSISMVEKLFGYKSPLYGRRTAQMKLKPLNFFSAKEFFPRYSLEEFVKVYGILGGTPAYLLEFNDEKSIEENLLDYFRADSFLYGDALFILREELEEPRNYFAIMEAIARGKTTLNEIVNETGLERATVGKYLSVLIDLDLVRREIPVTASWKSRKGRYYITDPYFAFWFRYVYPNSDLIETGEGEELIELVMKDFNNYLGWIFEEIAKQFLIELNKRKELPFRFMRIGKWWHKKEEIDLLALNERERKVLFVEVKWKNLSEREAKRILEKLERKSKLVGLEGWEMVYGLVAKRVEKKENWLVWDLKDFERLISFNAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKJ1</accession>
    <name>F0LKJ1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01850"/>
    <dbReference type="EnsemblBacteria" id="ADT84825">
        <property type="protein sequence ID" value="ADT84825"/>
        <property type="gene ID" value="TERMP_01850"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01850"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1849"/>
    <dbReference type="eggNOG" id="arCOG00887">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_280048_0_0_2"/>
    <dbReference type="OMA" id="FWRVANV"/>
    <dbReference type="OrthoDB" id="7616at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007555">
        <property type="entry name" value="DUF499"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04465">
        <property type="entry name" value="DUF499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1129" mass="129936" checksum="40767E4B23FF971F" modified="2011-05-03" version="1">MLREKIWNDVMDETLDEFSAPELNDVVSGRAHKIYSDAKEFFRRTYFSDSMLDLIEKVLSTLEGRGTNVFTVYSLFGGGKTHTLVTLYHILNHPDALLDEEVLRDYDIMKRKRLEHIAQRIKSLGKVNIAVIYGMGDIGNPIKPLDFGVYKVHTIWGYLAHLLGRYADIKAYDESLTVPDINSLRELLKEGKTLIMIDEVADYGNNLRRSNREDAKNYANNIPIFLERLSKAIIGTDNVLIVTLPIEVERGVLRETEKAYDKDYLEALWKAVAKLSGELVAPLRTERGSNDLIEVLKRRIFEKIDPNNKIKIIERYMVDMANEEIFGDTRDFLRELEVTYPFHPDYFTIMRTILERVPGLQKTRDLIKLTRKVVRRIHREEKEYSLVMPHHIDVFDNDLRGLLFQENYANYAGVVDVDLNPKVLKKYSQPELVKIIYEYIFLSTYPYDSPTPLTGFPDKFKISRGIYEVEIFEAMEWDSTKIHDAIEEIISRNYFIHLNYDDRHNVFWVWRIANVNQMVLAKKDELLRNKKGELIEKATAEIKKAIEGKPGKGKKSKGEQIKITLFEWKDVIFDPQIGDIVDDDKYKLLALYYEYVDEELLEDLILKHKGGTRKFRNTIVVTYPTPQGFNSILEAFAKVEACKEVKKEVDKIYSDYGKNVVKIQQSMIEHIENAAKDDLFTTIVQSFRKVAFPVNEGYRDSVKATEASTTSTSILETVYSVLISPEVEKVAEYLSFDELKAMLNIVGIDLSSRPYTFGEIRNYFRMNPALPMVEDERIKEALKEGLSRLEIGILTKSGKLVFKDVKEIAIVNGEIKKESTEQATIHQITLDDKILPKRIALEAQVSSLLQREETKTIERGKKKIRRKVEVFLEIDGQRIRLKDIVGDKDNISIKDEDINMLVEGNFVVVITEEELSDDFSDFEIEISPAYVSAHPEELIEVKVVIAPKDPNKSFEVKLKVDYGKLKETNGIVPFETVWHLKAPRESDEFRLYAESKDVEHVATLRVEVITPTIRTRKLTEEHIGGTLIKIENIRRLEHLKILQDAIGSEHILSGTAVIKANGSRVSMDLDRIPLDVATQVIEDSKEYLDGSDELNVDVTIQGEITITELLLKKLSVLNDKVTFVVELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKJ4</accession>
    <name>F0LKJ4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468124.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01853"/>
    <dbReference type="EnsemblBacteria" id="ADT84828">
        <property type="protein sequence ID" value="ADT84828"/>
        <property type="gene ID" value="TERMP_01853"/>
    </dbReference>
    <dbReference type="GeneID" id="10042169"/>
    <dbReference type="KEGG" id="tba:TERMP_01853"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1852"/>
    <dbReference type="eggNOG" id="arCOG04056">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444745_0_0_2"/>
    <dbReference type="OMA" id="IYDEFYF"/>
    <dbReference type="OrthoDB" id="68209at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="200" mass="23204" checksum="9C5EAD0F6C6DD2ED" modified="2011-05-03" version="1">MKPPVSREKIYSVVFDYTGIRIPEVARLAELNYIYTYQTIRALKREGYLTTASDGRIIILDRKGLIFKWARDKEVILNSLSPITIKLVPDYDMRNLVLFSGNSALWLLGKIISPAGGILYASEKTFKDLMKFKDPEGYPFKVYIYDEFYFKIRKELNGYYIPSWGMILADMLVQGMYTRLFDDVFETVVSIIEGEKNEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKT6</accession>
    <name>F0LKT6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CARDB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466963.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00688"/>
    <dbReference type="EnsemblBacteria" id="ADT83665">
        <property type="protein sequence ID" value="ADT83665"/>
        <property type="gene ID" value="TERMP_00688"/>
    </dbReference>
    <dbReference type="GeneID" id="10041006"/>
    <dbReference type="KEGG" id="tba:TERMP_00688"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.689"/>
    <dbReference type="eggNOG" id="arCOG05791">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_529600_0_0_2"/>
    <dbReference type="OMA" id="YEQRNET"/>
    <dbReference type="OrthoDB" id="22919at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="2">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="514" mass="57730" checksum="F3B5CB58A3CDE315" modified="2011-05-03" version="1">MNKWPAIAIILVLMFPIVPLVKAQPLIIISVSQEYFEGRPGDIIKIPVTVRNVGNETAYNITVYISGPVKGFQYTMAAISKLEPNQNTTVELTIYIKDDARAGTYDLKIVGRVGALLFEKPIKVRVLTVIDYKLDIQVKDRYLYGSDVEATLIVKSLSNGVIVGTISYELYSEEGLLKKDSWVTYINPQDKWSYTLFLPKPDVGKYTIILRAEFAGITKTITKNFLVYRRNLTYEAYFENGIIYVRVVDKEGNGVKDVPVEIEGVLFKTDPYGLVKYEAKEPGVYKIKLNLDGRIVETFVEVKKLFISWEQKNGTLILYTRDASGKGISNVSIEAIGPNGRVYAVTDENGRAEISLNETGYGLITVKAESSRYIGAEISITAEKPKPKETTITITTTRTPTPIQLNETPTQIEQPKRGYGYLPIIFVISAVLFGTTSYVAFFMPIILEEQLDKYYFVKVKAPKLRGIKNLRYEKVINAVDARATKGKVSIDGNKVVWEIEELGPEEEAFLQVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKU2</accession>
    <name>F0LKU2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Potassium uptake TrkH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_00694</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466969.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00694"/>
    <dbReference type="EnsemblBacteria" id="ADT83671">
        <property type="protein sequence ID" value="ADT83671"/>
        <property type="gene ID" value="TERMP_00694"/>
    </dbReference>
    <dbReference type="GeneID" id="26136096"/>
    <dbReference type="KEGG" id="tba:TERMP_00694"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.695"/>
    <dbReference type="eggNOG" id="arCOG04145">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030708_3_0_2"/>
    <dbReference type="OMA" id="LQWMGGM"/>
    <dbReference type="OrthoDB" id="13996at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004772">
        <property type="entry name" value="TrkH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00933">
        <property type="entry name" value="2a38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="494" mass="55419" checksum="B115FB451091F3CC" modified="2011-05-03" version="1">MLGVRRYINLTEDLFVVKNLIGALLQGIGLAYLIPPLIVWFYPNEIVYVYYFVIPGVISILLGAWLGRHVKMIEDVNLRQAMISAAFVWLFASFISVVPFMKIAHMSFIDSYFESMSAWTGTGLTMMSNLESYPHILLFWRSWMQWLGGIGIVLVALTILIRPGVAAARLYKAEARTERILPNLANTSKIIFQIYAILTLLGIYLYYINGMPMFDAVIHSMTGLGTGGMSSHDLSIGYFNSLSIEAVTIFLMIMGAVNFTVHYKMFKNRSIRHFFEDIQVRYMFIFLIPTIVLIGYSLITWNHMQIAKAFRESVFHAVSAITCTGFSIDDLSKYPELAKLLIGFLMVVGGGAGSTAGGIKLIRITLTYESLKWTIQQAILPKGAVIKRKVGNYIFSEDEIQEVFSFTMTYFAFLLIGTVWVMARLGVSIANAFFEVASAQGNVGLSVGITSPALPLDIKILLILHMWIGRLEIFSTLVFIVSALMLIPRVVERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKU6</accession>
    <name>F0LKU6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00698"/>
    <dbReference type="EnsemblBacteria" id="ADT83675">
        <property type="protein sequence ID" value="ADT83675"/>
        <property type="gene ID" value="TERMP_00698"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00698"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.699"/>
    <dbReference type="eggNOG" id="arCOG03803">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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    </dbReference>
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        <property type="entry name" value="DUF835"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="DUF835" evidence="2">
        <location>
            <begin position="229"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="368" mass="42629" checksum="73A54A6BDC6F08EE" modified="2011-05-03" version="1">METASIIGILNFISRWILFLVVTYRFIKTREKGWALLMFAFFINALDIESYILDPLGIQIKEEVYEIAGMIPNFLISLLIMWGVIHLKSKRAEIRHVIGMGVYVSLVYLWLFFAATPFFDELPFAIRALPSSLAFGVSLIYLGIMLRRYIVRKKTLEELFPWGLILLGALNLMYPLIREMPRFVNAAFLLAGVFRVISAIGAVKFAFYPIMPPQKKREKILPKEIYLFTDSKEVEYMFPTLFLENNVIIITRKDPRTFQLGNDFIIYWITRVGEGNIEEDPRIFAISPTKIDILVDLVARGLKQGYNVVYVDAFEYLMLENGFKAAFKFLLSLKDHVISKNGTLILVVKLDALEEKERKLIEREFSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKV2</accession>
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        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
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            <taxon>Euryarchaeota</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 6">Part of the 30S ribosomal subunit.</text>
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    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83681.1"/>
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        <property type="gene ID" value="TERMP_00704"/>
    </dbReference>
    <dbReference type="GeneID" id="26136107"/>
    <dbReference type="KEGG" id="tba:TERMP_00704"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.705"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080597_2_1_2"/>
    <dbReference type="OMA" id="NPNYVRR"/>
    <dbReference type="OrthoDB" id="116294at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_protein_S8e_arc"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S8e"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S8e/biogenesis_NSA2"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S8e_CS"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="131" mass="14667" checksum="17C8E02994CC29A8" modified="2011-05-03" version="1">MAIWQGRSLKKPSGGRIVLARKKRKRELGREPAFTRVGEYREERKIIRTFGGNRKVRLVQALYANVFDGGKGKKVKILGVVENPANRQYVRRNIITKGAIIQTEIGKAIVTSRPGQDGVINAVLIKEEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL36</accession>
    <name>F0LL36_THEBM</name>
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        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="TERMP_01969"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG00157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="YKIVYFF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="23"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="243" mass="26749" checksum="F8D063835379EF51" modified="2011-05-03" version="1">MLLSPDIINVERFPTKSPPWGSLVNNAIFILIHLPITLFLGLGLALLLRKEEVKGSSIIKSIIFLGMVIPMIVGGLITRFLFEQGAGVVPSIFGALGIKSLDITWTAYPQTALFAVILGSIWIWTGFSMLMYSAGLASIPRDYYEAALIDGASRFQIFRHVTWPLLKPITTVVVAMTLLWDLKIFDVVYVATGGGPGGASMVLALQMWDYFARELNYNYAAVVAVLLTALTLVPATWLLKRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL47</accession>
    <name>F0LL47_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01980"/>
    <dbReference type="EnsemblBacteria" id="ADT84954">
        <property type="protein sequence ID" value="ADT84954"/>
        <property type="gene ID" value="TERMP_01980"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01980"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1977"/>
    <dbReference type="eggNOG" id="arCOG04793">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112310_0_0_2"/>
    <dbReference type="OMA" id="NGMTHEY"/>
    <dbReference type="OrthoDB" id="68011at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="213" mass="25001" checksum="C7D246E0D4A09CFA" modified="2011-05-03" version="1">MRRLAIRYIISRFGGNAVTKDELKDVSEKFGIDIDYFVNYLLSQGYIVRILRGVYYVKTIEEIGLKRAPDIFKVIAKGLNKLNLIWYYGLFTALRLNGMTHEYFNMIFVLNDKVIRSKAVKILGENVKFVKIKPTLASFGIIKSNEIKFSDPEKTILDFIYLSRYNKRLKPHAEDILVEYGDKINWAILCSYLQKYPKSVQREVLKHERERIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL58</accession>
    <name>F0LL58_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00732</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467007.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00732"/>
    <dbReference type="EnsemblBacteria" id="ADT83709">
        <property type="protein sequence ID" value="ADT83709"/>
        <property type="gene ID" value="TERMP_00732"/>
    </dbReference>
    <dbReference type="GeneID" id="10041050"/>
    <dbReference type="KEGG" id="tba:TERMP_00732"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.734"/>
    <dbReference type="eggNOG" id="arCOG00749">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_10_0_2"/>
    <dbReference type="OMA" id="GFVKGMN"/>
    <dbReference type="OrthoDB" id="34606at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="213"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="420" mass="47214" checksum="75081E803D4E7BE7" modified="2011-05-03" version="1">MRRRQKIGTAILALFTIFVIASYFSVPKEELDNWENVVYWINYPKRAKPVWLGGISTVKLTPELNWSSQGYSSYVYTYEHKYDEKPNDIAVIISHPALHVIDVKRPDGILVNVYDGMLFQNITLNTNDRTALSIFRALRERFNLTDADLGTKTPTELLFSADSNFDTLKGTYTFRVLCNCSAPPEVIVYGTSYGLLGTDSYGRDIWAGFVKGMVNTLYLALFTTFMIIALGLMLGLISGYFRNLFSSIVTFFLEVLTALPILSILVVLTWVMSRQGIGARVEVNPIKFMLLVSILLVGKFAKTIRIMTIQEKSREHVTASISLGASGFHVIRRHILPVISEYSVRYFTFLMPRIVALISIFGFFGLIPGVNWGSFVVEALQQGALYGGYWWWVLSPGFAMAFLSLGFALVVSIDKPLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL66</accession>
    <name>F0LL66_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467015.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00740"/>
    <dbReference type="EnsemblBacteria" id="ADT83717">
        <property type="protein sequence ID" value="ADT83717"/>
        <property type="gene ID" value="TERMP_00740"/>
    </dbReference>
    <dbReference type="GeneID" id="10041058"/>
    <dbReference type="KEGG" id="tba:TERMP_00740"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.742"/>
    <dbReference type="eggNOG" id="arCOG00135">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_16_3_2"/>
    <dbReference type="OMA" id="TPDDMRG"/>
    <dbReference type="OrthoDB" id="52910at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004751">
        <property type="entry name" value="Drug_antiport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00900">
        <property type="entry name" value="2A0121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="4">
        <location>
            <begin position="7"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="405" mass="44954" checksum="8436A2312EDF491C" modified="2011-05-03" version="1">MTGLGKNFWLFAVGRFVSQIGWAVHEVALPLYILDKTKSGSMMSIFVMADIIPSLIFMPFAGVVGDRYNRKALMVGFDLLRGVLLFGVVFLNLLGIYQLLILQIVLAIMSTFFGASTSAMFPDLVESDKLEKANSVVSSFTIIARLIGPALGGLIYAIGGIKLAFTINALSFFGSGLFEIFIRYEWKTREIESLDEIIADIREGLSFLRSSRYLMILISFALFMNALGQPFGSVLEPYVYRVVLKLSSQQFGVLQSTLMVGMLLGNILVAARLGRRAGRFFFRSLFFNGAVMFAFVLLISPLTELSIRVIFISLLVINLLWGFSSAIINIPLQAKIQRAVPSELRGRVFSALGMLVNISTPLGLMVIGPLLDIYPAWEVAFGIWCLMFLVVLTYYIRFRDALVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLB9</accession>
    <name>F0LLB9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="2 9">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_00793</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="2 9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467068.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00793"/>
    <dbReference type="EnsemblBacteria" id="ADT83770">
        <property type="protein sequence ID" value="ADT83770"/>
        <property type="gene ID" value="TERMP_00793"/>
    </dbReference>
    <dbReference type="GeneID" id="26136246"/>
    <dbReference type="KEGG" id="tba:TERMP_00793"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.795"/>
    <dbReference type="eggNOG" id="arCOG00790">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335100_0_0_2"/>
    <dbReference type="OMA" id="LTCPRRI"/>
    <dbReference type="OrthoDB" id="75470at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="208" mass="25205" checksum="BF6E0724438B071D" modified="2011-05-03" version="1">MSDELLEFYASEALTCPRRIYFRLKGYPEKWPEFVRVRLNQGVKTHNVLGEILSKQFGFELEKHIVLRSSRLGFEIHGRIDAYRDFPIEIKGKTSLPRLPYEYHLAQLNIYLRWAESEYGYLYYVKLHENPHRVLKWIDFSSFPIVKGKNFKAFEIPYDEKLFKETIKQFYIVKKHYEKDKPPDGWRNYMCKFCPYYYICYGDNGYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLD2</accession>
    <name>F0LLD2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA_binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467081.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00806"/>
    <dbReference type="EnsemblBacteria" id="ADT83783">
        <property type="protein sequence ID" value="ADT83783"/>
        <property type="gene ID" value="TERMP_00806"/>
    </dbReference>
    <dbReference type="GeneID" id="26136258"/>
    <dbReference type="KEGG" id="tba:TERMP_00806"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.808"/>
    <dbReference type="eggNOG" id="arCOG04227">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112567_0_0_2"/>
    <dbReference type="OMA" id="IEHARFH"/>
    <dbReference type="OrthoDB" id="99870at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="144" mass="16740" checksum="CB1EEC485E990DDD" modified="2011-05-03" version="1">MVKKMPLDRLTDDDIREILTRYKRIALVGASPKPERASHDVMKYLLDHGYDVIPVNPRYEEVLGRKCYPSVLDIPGEVDIVDLFVRPEFTMEYVEQAIKKGAKVVWFQFNTYNREAFKKAKEAGLTAVAHRCIKQEHERLFGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLD5</accession>
    <name>F0LLD5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468260.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01990"/>
    <dbReference type="EnsemblBacteria" id="ADT84964">
        <property type="protein sequence ID" value="ADT84964"/>
        <property type="gene ID" value="TERMP_01990"/>
    </dbReference>
    <dbReference type="GeneID" id="10042305"/>
    <dbReference type="KEGG" id="tba:TERMP_01990"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1987"/>
    <dbReference type="eggNOG" id="arCOG02696">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116585_0_0_2"/>
    <dbReference type="OMA" id="YVFNNVF"/>
    <dbReference type="OrthoDB" id="91655at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009482">
        <property type="entry name" value="DUF1102"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06510">
        <property type="entry name" value="DUF1102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="165" mass="17673" checksum="148F1FF0946F7A4D" modified="2011-05-03" version="1">MISTKITLPLVAVLIFIAAVSISKPIPVSYALENGNTSFTIETPLPPYAFLYHGGNLTIDISKNSPFYPGYGEGLSRDAIYQFDDVIRVENNVTQTGASVICVIITSEMNGLKFYYSNTTPAESISITLGEYESANIGIFVNTTGYALGDVSGSFKIQAFEGACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLE8</accession>
    <name>F0LLE8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02003"/>
    <dbReference type="EnsemblBacteria" id="ADT84977">
        <property type="protein sequence ID" value="ADT84977"/>
        <property type="gene ID" value="TERMP_02003"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02003"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2000"/>
    <dbReference type="eggNOG" id="arCOG00683">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2257497_0_0_2"/>
    <dbReference type="OMA" id="IRERNGK"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="103" mass="12310" checksum="86E0C0578CE7F924" modified="2011-05-03" version="1">MDFNKTEKIVYEKYKREIGSATVQQICRKNAEAWKSFFTLIKKRKELPKWLKPKPPNYQKENGKRKPLIVLRNDQYRIEGNKLILKGLGKFKRLKVSLKEESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLF3</accession>
    <name>F0LLF3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S6e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps6e</name>
        <name evidence="5" type="ordered locus">TERMP_02008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468278.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02008"/>
    <dbReference type="EnsemblBacteria" id="ADT84982">
        <property type="protein sequence ID" value="ADT84982"/>
        <property type="gene ID" value="TERMP_02008"/>
    </dbReference>
    <dbReference type="GeneID" id="10042323"/>
    <dbReference type="KEGG" id="tba:TERMP_02008"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2005"/>
    <dbReference type="eggNOG" id="arCOG01946">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109671_1_1_2"/>
    <dbReference type="OMA" id="DGFPMRP"/>
    <dbReference type="OrthoDB" id="112720at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00512">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_S6e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020924">
        <property type="entry name" value="Ribosomal_S6e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_S6e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="PTHR11502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="125" mass="13703" checksum="F274A52324DBD7FF" modified="2011-05-03" version="1">MVTFKLVISDPKSGIAKQVEISGAEAEKLIGKRIGDEISAKELNLDLSAIFGKEIPADAKLLIRGGTDKDGFPMRPDVHGPRRVKILLSKGPGFRPKEKGERRKKTVRGNTISPEIAQINVKLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLM9</accession>
    <name>F0LLM9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467104.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00829"/>
    <dbReference type="EnsemblBacteria" id="ADT83806">
        <property type="protein sequence ID" value="ADT83806"/>
        <property type="gene ID" value="TERMP_00829"/>
    </dbReference>
    <dbReference type="GeneID" id="10041147"/>
    <dbReference type="KEGG" id="tba:TERMP_00829"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.831"/>
    <dbReference type="eggNOG" id="arCOG03789">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102063_2_0_2"/>
    <dbReference type="OMA" id="SRKAFYI"/>
    <dbReference type="OrthoDB" id="120114at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005489">
        <property type="entry name" value="DUF257"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03192">
        <property type="entry name" value="DUF257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="230" mass="26825" checksum="4945836560DE01A7" modified="2011-05-03" version="1">MVEKVSYLMEHFSKIKPGEIVLIEYTPDSFYPIAFYVLATYSLKLGLPLLIDDILDTLHLYKTYLDFAGLNTDFLYSEDVFVLKIGGHKEVGNVVSEIRLTGEFYIQYENYKAAFDSILSQRDFFINIVLGFDRLTDLYPSYQRYLFLLTRTHYLGNKRRTAFYFVNRELLKKTPLVLPIFEEISTSVVRLEKEGNTILVTFLKSPYPSLVGSQFKFSIEEMLNYLKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLR3</accession>
    <name>F0LLR3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Na(+) H(+) antiporter subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467138.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00863"/>
    <dbReference type="EnsemblBacteria" id="ADT83840">
        <property type="protein sequence ID" value="ADT83840"/>
        <property type="gene ID" value="TERMP_00863"/>
    </dbReference>
    <dbReference type="GeneID" id="26136312"/>
    <dbReference type="KEGG" id="tba:TERMP_00863"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.866"/>
    <dbReference type="eggNOG" id="arCOG03082">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121334_0_0_2"/>
    <dbReference type="OMA" id="TNPISAH"/>
    <dbReference type="OrthoDB" id="105926at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="127" mass="13949" checksum="8378272530736E12" modified="2011-05-03" version="1">MIAEIVGEFLVLFGTIFYFLSSLGLIRMPDVYNRMQTATKSATLGSLGVIIGVGIWAIGYVGSYAWLPKTLVIAVFLLLTNPISAHALIRAAYKSGIPLWEGSIVDKYGEYLKKEKEASEETKEGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLT4</accession>
    <name>F0LLT4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Capsular polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00884</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467159.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00884"/>
    <dbReference type="EnsemblBacteria" id="ADT83861">
        <property type="protein sequence ID" value="ADT83861"/>
        <property type="gene ID" value="TERMP_00884"/>
    </dbReference>
    <dbReference type="GeneID" id="10041202"/>
    <dbReference type="KEGG" id="tba:TERMP_00884"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.887"/>
    <dbReference type="eggNOG" id="arCOG02209">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051623_0_0_2"/>
    <dbReference type="OMA" id="LLVKHYF"/>
    <dbReference type="OrthoDB" id="103595at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="415" mass="47154" checksum="83AC958AD5E9C8C5" modified="2011-05-03" version="1">MKTKIISILNDKFVKDAAIMTLATTFANFFNYLYQLIMGRLLVPSEYGDLFSLLSLFYIFSVIFAVINVSTAKFTTIYSLRGEYEKIKGFLIEISKKLCVIGFIIAILAIFISDLLASFLNINTNLALIYLSLAIPFALLFTLHQGILRGLQRFTALGLSIVGWAFLKLLFGILLVLIWKNFLGGIAGFTLAYVIILALTFFYLRDILKFPKMHHVDLKGFIKYSWISFLALFSYSLMWNIDVILVKHYFPPFQAGIYAAISVLGKIVLFASVSIGIVLFPESAQRYEKNESHLQIFLRALGLTAAIGFGIIAVYVFFPYTIVKIIYGEGYMMIAEYLWKYGTAMLLLSLVNVTLNYALSINIKEIAYSLLLGNCLEIIFIYTFRTSIDYIINSLVTVMLITLIVSLLQIWRHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLU1</accession>
    <name>F0LLU1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468336.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02066"/>
    <dbReference type="EnsemblBacteria" id="ADT85040">
        <property type="protein sequence ID" value="ADT85040"/>
        <property type="gene ID" value="TERMP_02066"/>
    </dbReference>
    <dbReference type="GeneID" id="10042381"/>
    <dbReference type="KEGG" id="tba:TERMP_02066"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2063"/>
    <dbReference type="eggNOG" id="arCOG00722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154570_4_2_2"/>
    <dbReference type="OMA" id="GVEHYTE"/>
    <dbReference type="OrthoDB" id="118704at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="86" mass="9920" checksum="023128B3A7F46835" modified="2011-05-03" version="1">MSEVFVSVPQDLARILRVSEKDLPKVVRLYLAIELYREGKISLGKAAEIARVTKWEMMEILASKGIPLQYDEEDLKEDVETLERLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM31</accession>
    <name>F0LM31_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467176.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00902"/>
    <dbReference type="EnsemblBacteria" id="ADT83878">
        <property type="protein sequence ID" value="ADT83878"/>
        <property type="gene ID" value="TERMP_00902"/>
    </dbReference>
    <dbReference type="GeneID" id="26136347"/>
    <dbReference type="KEGG" id="tba:TERMP_00902"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.903"/>
    <dbReference type="eggNOG" id="arCOG01581">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OMA" id="HIVGPKD"/>
    <dbReference type="OrthoDB" id="97695at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="149" mass="17322" checksum="E56C1F3512FBBCF6" modified="2011-05-03" version="1">MRAKIDKVDIQLINLLAKNSRLTYKELAEQLKTTRQRISRRLDKLEKMGVIKKYTIIPDFDRLGYVYVILGITLKPAAPVDEIIERLKDDQDIKIIERAIGSHNLVIHLVAPKDMKDIEKKIHEISKKIDGIDKMDITFITEIVKFEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM37</accession>
    <name>F0LM37_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467182.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00908"/>
    <dbReference type="EnsemblBacteria" id="ADT83884">
        <property type="protein sequence ID" value="ADT83884"/>
        <property type="gene ID" value="TERMP_00908"/>
    </dbReference>
    <dbReference type="GeneID" id="26136353"/>
    <dbReference type="KEGG" id="tba:TERMP_00908"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.909"/>
    <dbReference type="eggNOG" id="arCOG01630">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_2"/>
    <dbReference type="OMA" id="GSYFKEP"/>
    <dbReference type="OrthoDB" id="90282at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="130" mass="14332" checksum="EDF328A8F9C75E1B" modified="2011-05-03" version="1">MKKVMIFTENAPKPIGPYSQAILVENPGKFLAISGQIPIDPESGQIVRGDIREQARQAIENLIAVLEAAGATVEDVVKVTVYLRDMGDFEEFNKVYEEYFGHSKPARAVVEVSNLPKGVKVEIEAIAIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM41</accession>
    <name>F0LM41_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hyaluronan synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467186.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00912"/>
    <dbReference type="EnsemblBacteria" id="ADT83888">
        <property type="protein sequence ID" value="ADT83888"/>
        <property type="gene ID" value="TERMP_00912"/>
    </dbReference>
    <dbReference type="GeneID" id="10041229"/>
    <dbReference type="KEGG" id="tba:TERMP_00912"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.913"/>
    <dbReference type="eggNOG" id="arCOG01389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_798373_0_0_2"/>
    <dbReference type="OMA" id="RWFLGDL"/>
    <dbReference type="OrthoDB" id="65802at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="39"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="349" mass="39839" checksum="CD84E888A7281FE3" modified="2011-05-03" version="1">MLLEITLLIIVLWDAYFFFNYIISLLWTYRIKEWTPLVSIIIPAYNEEGNIKESIKSALSQDYPALEVIVVDDGSEDKTFKTASSIKDERLKVFRKKHEGKAKALNFGLTKAQGEIIVTTDADTVLDNSAVKELVKRFYDESVLGVGGQVRVLADSLLERAQDAEHLRIAMFRRAKELEDLSVAPGPISAFRKEALEKIGGFVKSRVEDYATTRKIKKFGKVVYAPKAKAYTKMPNSLKTLWIQRRRWFLGDLMHLGGGLSKEWTFLILSDIIALFDVLVPLLLMIHRNWALLAAFIAFEIITMLIPTLIEGGSMVNALMFPVFLWFWALFYLTLHIYGYLCLLKSRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM88</accession>
    <name>F0LM88_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ordered locus">TERMP_00959</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467233.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00959"/>
    <dbReference type="EnsemblBacteria" id="ADT83935">
        <property type="protein sequence ID" value="ADT83935"/>
        <property type="gene ID" value="TERMP_00959"/>
    </dbReference>
    <dbReference type="GeneID" id="10041276"/>
    <dbReference type="KEGG" id="tba:TERMP_00959"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.962"/>
    <dbReference type="eggNOG" id="arCOG00858">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079546_0_0_2"/>
    <dbReference type="OMA" id="MGGTHPG"/>
    <dbReference type="OrthoDB" id="48934at2157"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04253">
        <property type="entry name" value="AAK_UMPK-PyrH-Pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_A">
        <property type="entry name" value="PyrH_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011818">
        <property type="entry name" value="Uridylate_kinase_arch/spir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02076">
        <property type="entry name" value="pyrH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="114"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="227" mass="24825" checksum="3BB445ADED348490" modified="2011-05-03" version="1">MRIVFDIGGSVLVPDKPDIDFIKKLAYQLVKISEDHEVAVVVGGGRVSREYIKAAKTFTPNETFKDYIGIHITRANAMLLIAALGEKAYPFVVQDFRKAWEVIQLKKIPIMGGTHPGHTTDAVAALLAEYLQADLLVVITNVDGVYDSDPRENPNAKKLRKITTAQLVEIAMQGESKAGGSSVVDALAAKFIQRGKIRTYVVGKNDAVNLFDVIRGKHNGTIVEPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM90</accession>
    <name>F0LM90_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA 2'-phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kptA</name>
        <name evidence="6" type="ordered locus">TERMP_00961</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR&gt;P). May function as an ADP-ribosylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00961"/>
    <dbReference type="EnsemblBacteria" id="ADT83937">
        <property type="protein sequence ID" value="ADT83937"/>
        <property type="gene ID" value="TERMP_00961"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00961"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.964"/>
    <dbReference type="eggNOG" id="arCOG04063">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052998_4_1_2"/>
    <dbReference type="OMA" id="TEEPVHC"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00299">
        <property type="entry name" value="KptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022928">
        <property type="entry name" value="RNA_2'-PTrans_KptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PTHR12684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="215" mass="25445" checksum="9AC3F61124CBD3EF" modified="2011-05-03" version="1">MISLLFTLSSGEPSMRDIYIHNGKFTEEHKGELFLNGRKRVKLSKLMTYILRHSPWEFDLNPDDFGFIELDEFIKALKSVYPWVKEEHVRAVAELDPKGRFEIREDKIRARYGHSYEVFLDHEEDTESRTLYHGTPRKNLDSILKEGLKPMKRRFVHLTKDKTEAYYTGLRHGKDVVILVIDAECLRRKGYRIYKAGKNVRIVKYVPPECIVLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMA2</accession>
    <name>F0LMA2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468421.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT85125">
        <property type="protein sequence ID" value="ADT85125"/>
        <property type="gene ID" value="TERMP_02151"/>
    </dbReference>
    <dbReference type="GeneID" id="10042466"/>
    <dbReference type="KEGG" id="tba:TERMP_02151"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2148"/>
    <dbReference type="eggNOG" id="arCOG03881">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170077_0_0_2"/>
    <dbReference type="OMA" id="PEFYGIA"/>
    <dbReference type="OrthoDB" id="112607at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="125" mass="14925" checksum="05E31481A64C34A2" modified="2011-05-03" version="1">MVHQYIKEKTKEFTKEEKERRYKYLGKEVIDYGDPGLDSIPEFYGIANAIWRDWKEGEISTKTALGRLALLKLLTYKTKNKKIQDIPDEELEEVRKFIDYVIQVIKNESRRKGEPEEERQIEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMA4</accession>
    <name>F0LMA4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="7">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ileS</name>
        <name evidence="11" type="ordered locus">TERMP_02153</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468423.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02153"/>
    <dbReference type="EnsemblBacteria" id="ADT85127">
        <property type="protein sequence ID" value="ADT85127"/>
        <property type="gene ID" value="TERMP_02153"/>
    </dbReference>
    <dbReference type="GeneID" id="10042468"/>
    <dbReference type="KEGG" id="tba:TERMP_02153"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2149"/>
    <dbReference type="eggNOG" id="arCOG00807">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_2"/>
    <dbReference type="OMA" id="HLGTAWN"/>
    <dbReference type="OrthoDB" id="4914at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="711"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="625"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT85127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1065" mass="125577" checksum="C8B3E1F185AFFEC9" modified="2011-05-03" version="1">MIKEPEFREYNAQLLEEKMEKFWAENNIYEKVKQSRADGPKYYFLDGPPYVSGAIHLGTAWNKIIKDMIIRFRTMQGYNVRRQPGFDMHGLPIEVKVEQALGLKIKKDIEEKIGVDNFIKKCREFALRNLKIMTEQFKMLGVWMDWDNPYMTIKNEYIESAWFTLKKAWEKGLLEKDMRVLHWCPRCETALAEHEVRGEYKIREDPSIYVKFPLEGKENEYLLIWTTTPWTLPANLAVAAHPEYDYAKVKVELDGKEEYWYLAKALVDKVLGEIGVEGEIVEEFKGKDLEGLRYVHIFLEEYPRQKEFREKYEWAHRVILGDFVTLGEGTGLVHSAPGHGEEDFEVGRKYGLPVYSPLDDEGRYVEGKWKGVYVKDADPEIIEYLKEKGLLVKASTIKHKYPHCWRCKTPLIFRATEQWFLKVSKVKEQIIKENDEKVTWYPDWVKIRFDNGVRDSGDWVISRQRYWGIPLPIWQSEDGEIYIVGSFRELVELAVALEVNGERIELPESYEEKLKVIEEKLGPEDLHRPYVDAFIIKVNGKEMKRIKDVLDVWFDSGIASWASLGYPREKELFEKLWPADFIVEGEDQVTKWFYSQQAASVIAFDTVPYRHVAMHGYVLDEKGDKMSKSLGNIIRPEEVVQKEGRDAFRFYMLWATTPWENLRFSWKGLAQVKRMLNILWNVYILAATYMSLDKFEPGKVNPEELPFREEDKWVLSRVNSLVETVTNGIETFYLTRATRGIYDFVVEDLSRWYVRLIRKRLWVEGDDPDKLAAYWTLWKVFDVLLRLMAPFTPYIAEAIYQNMIARKESVHMEDWPVKEFTDEELEKEMAIVRKIVEAGAAARQKARIKLRYPVRQILIETEDELTKKAVERLNRILRDQLNAKEVKVAKVEREIKVKPNFAKLGPHFKGDAKLIAKWIDEQNDRELYEKLMKGKLKVEIEGKEFTLERDHIVVEEQLPDFLVGEEFDYGKVFVDKTLTRELMMEGLAREFVRRIQEMRKRLDLDVNDRIKVYIETTEENKALLKDMLDYIKRETRAVEVLFEKPKGYVVDWEDVSAKIGVEKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMC3</accession>
    <name>F0LMC3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribose-5-phosphate isomerase A</fullName>
            <ecNumber evidence="2">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Phosphoriboisomerase A</fullName>
            <shortName evidence="2">PRI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpiA</name>
        <name evidence="3" type="ordered locus">TERMP_02172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468442.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02172"/>
    <dbReference type="EnsemblBacteria" id="ADT85146">
        <property type="protein sequence ID" value="ADT85146"/>
        <property type="gene ID" value="TERMP_02172"/>
    </dbReference>
    <dbReference type="GeneID" id="10042487"/>
    <dbReference type="KEGG" id="tba:TERMP_02172"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2167"/>
    <dbReference type="eggNOG" id="arCOG01122">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_1_1_2"/>
    <dbReference type="OMA" id="YDWDEVN"/>
    <dbReference type="OrthoDB" id="98657at2157"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="PTHR11934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="98"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="229" mass="25184" checksum="E8D2FC156012E672" modified="2011-05-03" version="1">MNTEEMKKLVAKEALKYIEDDMIVGLGTGSTTAYFIKMLGKMIMNEELFDVYGLPTSYQARILALESGVPVVSLDEVDAIDIAVDGADEVDPHLNLIKGRGAALTMEKIIEYRAGTFLVLVDGSKLVEYLGQKMPVPIEVIPAAWRVIKEELEVFNATAELRMGVKKDGPVVTDNGNFILDAKFERIEDPLDLEIELNNIPGVVENGIFADIADIVLVGTKEGVKKLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LME9</accession>
    <name>F0LME9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vitamin B12 ABC transporter B12-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02198"/>
    <dbReference type="EnsemblBacteria" id="ADT85172">
        <property type="protein sequence ID" value="ADT85172"/>
        <property type="gene ID" value="TERMP_02198"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02198"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2193"/>
    <dbReference type="eggNOG" id="arCOG04233">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG10029">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_403165_0_0_2"/>
    <dbReference type="OMA" id="PRWRAIK"/>
    <dbReference type="OrthoDB" id="90656at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="82"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="399"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="711" mass="79552" checksum="86BBF4D9D537D950" modified="2011-05-03" version="1">MKGSKKVLALLVMSVLALSVFSAGCINQGYQTETTSKVTAKSSPTQSIQEQKPETTTSKAKYPITLTDFAGRKVTIEKPPERVIVLTSYWAEILCILGVQDRIVGIGKYIPYDPYIPDDVKKKPVVGSSFKGLNWETVASLNPDLIIVDWYGGKYKDAETIKKAEELGIPVIALSAKSVEDNIKVVEILGKVFGKEEKAEELASWMKEKLDEVNKIASQIPADKKKNVLLISAPKDIGGPITVYAKGSAWASIVELVGAHNLAFDKEFDTQWPKLDLEKIIAYWGDKADVIIVTSFSQDKLEKAVNDIKNDPRWREIKAVKEGHVYGILAGSKAFLDWGPRIIVGVYQMGGLIYPEYYPEWKPIAKELLENFYGVKYEASISVMDSMGRKVTLEKVPERVIVLSSYWAEVMYCLRVADKIVGIDKYTPYDQFLPESIREKPKVGSTYSGINWETVAGLNPDLIIMGRWKGSFTKGEQEVIERSKELGIKVLAFGIPDSNVTGTKMPYENIRIIRVLGKIFDKERKAEELASFLEKYYNEALDIASKIPADKKKNVLIVYGSSIVGKYATGAISISYKGSAYAETAELVGAYNVAFDYNFSTQYPKLDLEKLIAYFGDKTDVLIVVDWDAERLKEAVEKIKSDPAWQEIKAVKEGNVVGILVSSWSKDAVALYGPRFITGIYAFGHAIYPEYYPDWKPIYEELLKKFYGMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMG1</accession>
    <name>F0LMG1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnz</name>
        <name evidence="10" type="ordered locus">TERMP_02210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468480.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02210"/>
    <dbReference type="EnsemblBacteria" id="ADT85184">
        <property type="protein sequence ID" value="ADT85184"/>
        <property type="gene ID" value="TERMP_02210"/>
    </dbReference>
    <dbReference type="GeneID" id="26137849"/>
    <dbReference type="KEGG" id="tba:TERMP_02210"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2205"/>
    <dbReference type="eggNOG" id="arCOG00501">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_2_1_2"/>
    <dbReference type="OMA" id="GTQRQMM"/>
    <dbReference type="OrthoDB" id="111803at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT85184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="307" mass="35742" checksum="FDC3BF0E62369719" modified="2011-05-03" version="1">MLEVIFLGTGGIMPNKERNVPSIALRYEGEIILWDVGEGTLRQLNTAKLSPMRIEKIFITHFHGDHYLGLMSLIQTMTLWNREKPLHIYGPKYTFEFIQNYLKSGFFAPSFEIHVHELGEARLKFGDYEIWSFKVEHGIPALGYVFKEKDKRGNFNLEKIRELGLKPGPWMKELELKGKIEINGRTIYLEDVTGERRRGVKVVYTGDTEPCKRIELFSERADLLIYEATYLTGEERGESYHSTVSEACEVAKKAKVKLLALFHRAPRYKYDEYLQKAEQLCNHKFIVPKDFDRISFKGESYELSSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMG7</accession>
    <name>F0LMG7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hydro_57 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467244.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00970"/>
    <dbReference type="EnsemblBacteria" id="ADT83946">
        <property type="protein sequence ID" value="ADT83946"/>
        <property type="gene ID" value="TERMP_00970"/>
    </dbReference>
    <dbReference type="GeneID" id="26136419"/>
    <dbReference type="KEGG" id="tba:TERMP_00970"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.973"/>
    <dbReference type="eggNOG" id="arCOG03278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_757838_0_0_2"/>
    <dbReference type="OMA" id="QYAEIPK"/>
    <dbReference type="OrthoDB" id="27534at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040042">
        <property type="entry name" value="Branching_enz_MT3115-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41695">
        <property type="entry name" value="PTHR41695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="1">
        <location>
            <begin position="26"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="365" mass="41579" checksum="2FD287F3C467058E" modified="2011-05-03" version="1">MANALVFHANLQYAEIPKSEIPKVVEKSYIPTILELIKSEIPFALNITGFSLKYLPKDLITLIKEGVESDLIEITGTAYTHAILPLLPLDRVEAQIMKDRAVKERTFEVKPKAFWLPELAYDPIIPAILRDCGYDEVFVDGEALLFSNHLNSAIKPIKPLYPHLIKAQRGEGFVYWNYLLGLKELKSAIKLVFGGKVTLKAVKEITGIPVWVAVNTAVMLGIGGFPLMNVKKAVKWIKGLDEIILYGTDLEFFGYRDLAGYVLSIQKLRELINELNNEIVLPSRLKHSGRSLYLRTSSWAPDKGLDIWTKDWGNRRLNMLSWELKWEHAFLAENSDARGWEPLAERRLDAFKAIYQAWREGYGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMI7</accession>
    <name>F0LMI7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467264.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00990"/>
    <dbReference type="EnsemblBacteria" id="ADT83966">
        <property type="protein sequence ID" value="ADT83966"/>
        <property type="gene ID" value="TERMP_00990"/>
    </dbReference>
    <dbReference type="GeneID" id="10041307"/>
    <dbReference type="KEGG" id="tba:TERMP_00990"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.993"/>
    <dbReference type="eggNOG" id="arCOG01290">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015525_2_1_2"/>
    <dbReference type="OMA" id="PFDPWKS"/>
    <dbReference type="OrthoDB" id="37613at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="14"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="280" mass="32977" checksum="6B8A1A41DD586C65" modified="2011-05-03" version="1">MYIRPFDPWKSKLCTCPFKYTLNVYTGCDHACIYCYITAYIPKAFKVRIKENLLLNLEKELRKFDKRFIISLSYSSDPYPTVERQLGITRKVLQLFKRYNVRCTILTKSDIFERDLDILRELKCAVGITVTTIDEEKAKALEPNAPSPKDRIRALRKAKKSGIPVYARIDPIIPFYTWEEFEETVNALSFVSHITVSTLKLRPDSWKRMKAKFPELMKKLEPLYKRGERIGGYYYLPRDFRMKILKEAKKIIEERRITFGSCREGYYSYPTCDGSHLVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMK8</accession>
    <name>F0LMK8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">QueD-like Queuosine biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467285.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01011"/>
    <dbReference type="EnsemblBacteria" id="ADT83987">
        <property type="protein sequence ID" value="ADT83987"/>
        <property type="gene ID" value="TERMP_01011"/>
    </dbReference>
    <dbReference type="GeneID" id="10041328"/>
    <dbReference type="KEGG" id="tba:TERMP_01011"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1014"/>
    <dbReference type="eggNOG" id="arCOG02172">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111016_6_0_2"/>
    <dbReference type="OMA" id="WEDPRSY"/>
    <dbReference type="OrthoDB" id="104644at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="151" mass="17804" checksum="2E88558FA1DC4560" modified="2011-05-03" version="1">MEFKVVERKIGWHKDFDSSHFLALPYDSKCLRIHGHTYNVDVEIWGDLDERGMIFDFNHLSNLIKEVDHRILTSIEWIKEEGDHIIIVQNDKELKLPKKEVVIVDAPNVTAELIAEWFAKRIAEKAGENVKRIKVRVWEDPRSYAEIVLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMM2</accession>
    <name>F0LMM2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467299.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01025"/>
    <dbReference type="EnsemblBacteria" id="ADT84001">
        <property type="protein sequence ID" value="ADT84001"/>
        <property type="gene ID" value="TERMP_01025"/>
    </dbReference>
    <dbReference type="GeneID" id="26136475"/>
    <dbReference type="KEGG" id="tba:TERMP_01025"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1028"/>
    <dbReference type="eggNOG" id="arCOG05762">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2550464_0_0_2"/>
    <dbReference type="OMA" id="FDIEEWE"/>
    <dbReference type="OrthoDB" id="126194at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="81" mass="9612" checksum="4FD25C74989AF94E" modified="2011-05-03" version="1">MNVIIYGIIVILLMLNIVLALLYLSVRRSPYYVVYDEETKNALKRRVLHLKEDLESELVDFDIAEWEKTLEESIEEEIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMP7</accession>
    <name>F0LMP7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01050"/>
    <dbReference type="EnsemblBacteria" id="ADT84026">
        <property type="protein sequence ID" value="ADT84026"/>
        <property type="gene ID" value="TERMP_01050"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01050"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1053"/>
    <dbReference type="eggNOG" id="arCOG05748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1607250_0_0_2"/>
    <dbReference type="OMA" id="LLTNHAK"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="163" mass="19031" checksum="7D4D13CF7FAA4139" modified="2011-05-03" version="1">MLLTNHAKQRIIKRLSKRRKLERVYSALLDFLKNAERIEVNEKIIIFTDKRKSLVCTKLDAEFLGFNEIMKKVGDINETYECVFWGEEKFAKVTIPKKFLEHIPEGKYYFYINKEKKALYIGDEPPLLAITLRPAKRKERIPESETNHQASTGTTYMSPNGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMU6</accession>
    <name>F0LMU6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="10" type="ordered locus">TERMP_01099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467373.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01099"/>
    <dbReference type="EnsemblBacteria" id="ADT84075">
        <property type="protein sequence ID" value="ADT84075"/>
        <property type="gene ID" value="TERMP_01099"/>
    </dbReference>
    <dbReference type="GeneID" id="10041416"/>
    <dbReference type="KEGG" id="tba:TERMP_01099"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1102"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="RTQKDFA"/>
    <dbReference type="OrthoDB" id="35979at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="9">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="114"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="210"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT84075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="299" mass="33978" checksum="C08D98E97CD7AD92" modified="2011-05-03" version="1">MEKRRVCPVCGSTEFIYDPEHGEIVCSKCGFVIEENIVDMGPEWRAFDASQREKRSRTGAPESILLHDKGLSTDIGSDRNITGLMREKMYRLRKWQSRLRVSDAAERNLAFALSELDRIASQLKLPKHVEEEAARLYREAVRRGLIRGRSIESVIAACVYAACRLLKIPRTLDEIADIARVDKKEIGRSFRFIARNLNLTPKKLFVKPTDYVNKFADELGLSEKVRRRAIELLEEAYNRGLTSGKSPAGLVAAALYIASLLEGEKRTQREVAEVARVTEVTVRNRYKELVEKLGLKITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMW0</accession>
    <name>F0LMW0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ORFZ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467387.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01113"/>
    <dbReference type="EnsemblBacteria" id="ADT84089">
        <property type="protein sequence ID" value="ADT84089"/>
        <property type="gene ID" value="TERMP_01113"/>
    </dbReference>
    <dbReference type="GeneID" id="10041430"/>
    <dbReference type="KEGG" id="tba:TERMP_01113"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1116"/>
    <dbReference type="eggNOG" id="arCOG03142">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080186_0_0_2"/>
    <dbReference type="OMA" id="DFEVYHG"/>
    <dbReference type="OrthoDB" id="96593at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="261" mass="29878" checksum="81CB6A1F30B06612" modified="2011-05-03" version="1">MRVAIVTRNARVYYIASKVLKEYRIPFYSLRLDEKIPFDVEVVLTGEEDYDKINFPVKIIVKNENFIDELLARLEGRKRFKKVFIAIDPGERPGVAVVGDNRVVEVYHLKSPKDVDVILDLLEKYPKARIKIGHGAKRHRILMLKALARVLGESYPVIIVNERGTTPKVGGIEGSQVQDIVASINIALREGREVKIGELIYTNEPTKREIEHIKSKSRIMSGGRITISSELAREVAKGNLTLEEAIEIYQRRDKDDFRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMW3</accession>
    <name>F0LMW3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease P protein component 4</fullName>
            <shortName evidence="2">RNase P component 4</shortName>
            <ecNumber evidence="2">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Rpp21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rnp4</name>
        <name evidence="3" type="ordered locus">TERMP_01116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467390.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01116"/>
    <dbReference type="EnsemblBacteria" id="ADT84092">
        <property type="protein sequence ID" value="ADT84092"/>
        <property type="gene ID" value="TERMP_01116"/>
    </dbReference>
    <dbReference type="GeneID" id="10041433"/>
    <dbReference type="KEGG" id="tba:TERMP_01116"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1119"/>
    <dbReference type="eggNOG" id="arCOG04345">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079140_3_1_2"/>
    <dbReference type="OMA" id="HVVITCL"/>
    <dbReference type="OrthoDB" id="128960at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00757">
        <property type="entry name" value="RNase_P_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016432">
        <property type="entry name" value="RNP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004878">
        <property type="entry name" value="RNase_P_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="127" mass="15694" checksum="7AD3A6BD0301E22C" modified="2011-05-03" version="1">MSKKFLRKKEQREKRKIALERINILFTLAERVFPYDKELANRYVEIALAVQQKAKVRMPRKWKRRYCKKCHSFLLPGVNAQVRLRQKRMPHVVIKCLECGHIMRYPYLREQKERRRRRLEERVKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMX3</accession>
    <name>F0LMX3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467400.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01126"/>
    <dbReference type="EnsemblBacteria" id="ADT84102">
        <property type="protein sequence ID" value="ADT84102"/>
        <property type="gene ID" value="TERMP_01126"/>
    </dbReference>
    <dbReference type="GeneID" id="10041443"/>
    <dbReference type="KEGG" id="tba:TERMP_01126"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1129"/>
    <dbReference type="eggNOG" id="arCOG00492">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_2"/>
    <dbReference type="OMA" id="GGCFNNY"/>
    <dbReference type="OrthoDB" id="51060at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="35"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="405" mass="45240" checksum="781F77CAE0EED913" modified="2011-05-03" version="1">MDYNKFLAGRANWIKGSALAEVMKKAAELQSKGKNLISLAAGDPDPNLIPREVLGKLAKDVLANIPSSVMYTPANGIPELREEVAKFLKKYEHVEVSPEEIVITVGGTGALDLLGRILIDPGDVVITENPSYINTILAFEQLGAKVEGVPIDSKGMKPDALQEKIRELKSKGQKIKFIYTIPTGQNPMGVTMSEERRKALLEIASEHDLLIVEDTAYNFMKYEDREIRSLKALDKEGRVIVAGTLSKVLGTGFRIGWVVAKGEIRDKVLMEKSPIDFCAPTISQYIALEYLKRGYFEEYHLKRALPGYKEKRDAMVNALQEHLPNAEFTKPIAGMFVMLFLPENADGMAFANELMERKGVVVVPGKPFYTDESGRNTIRLNFSRPSKEEIEEGIKRLAELYNEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMX9</accession>
    <name>F0LMX9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Maltose transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467406.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01132"/>
    <dbReference type="EnsemblBacteria" id="ADT84108">
        <property type="protein sequence ID" value="ADT84108"/>
        <property type="gene ID" value="TERMP_01132"/>
    </dbReference>
    <dbReference type="GeneID" id="10041449"/>
    <dbReference type="KEGG" id="tba:TERMP_01132"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1135"/>
    <dbReference type="eggNOG" id="arCOG00159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_2"/>
    <dbReference type="OMA" id="NTYLMYG"/>
    <dbReference type="OrthoDB" id="57718at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="80"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="289" mass="32490" checksum="84FC0DFB00A41353" modified="2011-05-03" version="1">MKDVETRPSRYEWVIILAILFASLPLILGFSLLVLSSFSKEMVTNLDLKSFHFTLENWINVFQGKLATTGGIRTNILKVTFHTLVVALGVSGVVTFISALAGYSLSRIDFKGRKHMMILLLILHAFPGVALIVGVYLLYRLTFPQSPDLIRLYSFFYVILARAALEIPMSVWLMKGFFDTIPWEFEWSGIIDGASRIKVWRKIMLPLIKPGILAVALFAFLAGWQDIIYVRTFLIDQTLATFIEANIEAEYTHMPLIAAAGTLYLLPTIIFFLTAQQILLQGYSGGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMY3</accession>
    <name>F0LMY3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_01136</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467410.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01136"/>
    <dbReference type="EnsemblBacteria" id="ADT84112">
        <property type="protein sequence ID" value="ADT84112"/>
        <property type="gene ID" value="TERMP_01136"/>
    </dbReference>
    <dbReference type="GeneID" id="10041453"/>
    <dbReference type="KEGG" id="tba:TERMP_01136"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1139"/>
    <dbReference type="eggNOG" id="arCOG00770">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006515_9_0_2"/>
    <dbReference type="OMA" id="IREQFFR"/>
    <dbReference type="OrthoDB" id="31834at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT84112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="642" mass="73943" checksum="16F1C7CACAEE76E3" modified="2011-05-03" version="1">MRDYFPYKSLRPNQEEFISLVDEAVRKGENLIIEAPTGFGKTISVLAGVLPYALSMGFKVVYLARTHKQMDRVIEELKEINKINPVSGVEFRSRKELCLHSYIQNFVPDAYNAMIVCKNLKKLHKCDYFENVKKKKDEFSEIVEYFLNSPSQPIEILSYSNLLELCPYEVTRKVGEKANVIVASYLYMLNPAIRNAFIESLGVDYEDLIVIFDEAHNLPNQAIDVLSDKITLNSITRAVKEAEEYNEHEIANFLSIFLKGLENLYNERLKDREVEEIPILPESIFSHVFDILNISERLLVRILREIVEVGDAIREDKIEKNKPPRSYVGRVGEFLLNWLSVIGREDYLFIMSKDRGFSLELVALDPSKALDFINDIQSAIFMSGTLTPLEAFKDIMGIENAKLKKFPRMVKKENALVLVAKDVSTRGEERNLELYRKMAEYIVEAVKLIPKNVGVFTASYEVLQGLLSANVHLRIEEEVGKKVFIEKKNASSKENDILVRAFKEEAKREGGVLLGVMGGRNSEGQDYSGDEMNGVVLVGIPYARPTPRVQAQIRYFEKKFPRKGRYYGYYLPAHRKLVQAAGRVHRSAEEKGAIIILDYRVLWSSIRKDLPDWMNETMKPVNLPRMKLYLRRFYRNLEEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMZ0</accession>
    <name>F0LMZ0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF4040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_01143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467417.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01143"/>
    <dbReference type="EnsemblBacteria" id="ADT84119">
        <property type="protein sequence ID" value="ADT84119"/>
        <property type="gene ID" value="TERMP_01143"/>
    </dbReference>
    <dbReference type="GeneID" id="10041460"/>
    <dbReference type="KEGG" id="tba:TERMP_01143"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1146"/>
    <dbReference type="eggNOG" id="arCOG03076">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173139_3_0_2"/>
    <dbReference type="OMA" id="PLCYILL"/>
    <dbReference type="OrthoDB" id="123006at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="8">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="84" mass="9233" checksum="AFD30CD1D11FCBF1" modified="2011-05-03" version="1">MIEIHLLMLLITVLIGLIFSYLAIIEKDLLKAIGFSAVQAIAYAIAFYILMAPDIVLAYVAIAVGIYTALLVFVVGKTQRYEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN14</accession>
    <name>F0LN14_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467441.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01167"/>
    <dbReference type="EnsemblBacteria" id="ADT84143">
        <property type="protein sequence ID" value="ADT84143"/>
        <property type="gene ID" value="TERMP_01167"/>
    </dbReference>
    <dbReference type="GeneID" id="10041484"/>
    <dbReference type="KEGG" id="tba:TERMP_01167"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1170"/>
    <dbReference type="eggNOG" id="arCOG01430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_2"/>
    <dbReference type="OMA" id="GIRRWPE"/>
    <dbReference type="OrthoDB" id="47519at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="1">
        <location>
            <begin position="3"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="273" mass="30627" checksum="1648D7A70BF919B8" modified="2011-05-03" version="1">MYFAKLEFFNPFSRSIKDRAVFNMLMKARERGEINGRNKLFEATSGNVGIAMASIANILGVKFRAYLPKPTPTTTEILLRVLGAEVIRTEFDTIDPAMVEFVKREAEKNNAVNLNQFENEDNFEAHYKYTAREIEKQLESIGKKPDVIVAGIGTSGHIAGISKYLKEKYDTKIIGVVPAKGEKIPGIKRLETKPKWVPMVEIDQIVEITLKEAIEGAIKIAKNDGILIGLSAGATVRALEMLRDEYKGTAVLMFPDDGFKYVEIFERYLSGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN27</accession>
    <name>F0LN27_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467454.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01180"/>
    <dbReference type="EnsemblBacteria" id="ADT84156">
        <property type="protein sequence ID" value="ADT84156"/>
        <property type="gene ID" value="TERMP_01180"/>
    </dbReference>
    <dbReference type="GeneID" id="10041497"/>
    <dbReference type="KEGG" id="tba:TERMP_01180"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1183"/>
    <dbReference type="eggNOG" id="arCOG00002">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_1_3_2"/>
    <dbReference type="OMA" id="CAKDIRY"/>
    <dbReference type="OrthoDB" id="121662at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="154" mass="18050" checksum="039A3F92EE59BDBC" modified="2011-05-03" version="1">MERPKFKGHLKLLVLHLLSKKPMHGYAVMKGLEEEFGIPAPSAGVIYPILFSLKRAGLIETAGSGRREKKVYKITEDGVRYLKEHEEELREAIKLARIYREFSEMGGRELREAFRLLFDRFDNLTEKQREELSKIIREFAKKIKFIVEFGDSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN30</accession>
    <name>F0LN30_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type multidrug transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467457.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01183"/>
    <dbReference type="EnsemblBacteria" id="ADT84159">
        <property type="protein sequence ID" value="ADT84159"/>
        <property type="gene ID" value="TERMP_01183"/>
    </dbReference>
    <dbReference type="GeneID" id="10041500"/>
    <dbReference type="KEGG" id="tba:TERMP_01183"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1186"/>
    <dbReference type="eggNOG" id="arCOG01467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_3_2"/>
    <dbReference type="OMA" id="HSLPPFW"/>
    <dbReference type="OrthoDB" id="77595at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005942">
        <property type="entry name" value="Daunbcin-R_ABC-transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01247">
        <property type="entry name" value="drrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="4"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="271" mass="29629" checksum="2C96F4396F61EFA5" modified="2011-05-03" version="1">MKAFTTMAYRQIKRFFRARSRVIGMFVNPLMWLIFFGLGWSKVFNFPAASALFGGVDYLSFLAPGITAMTIFNASFIAGISVIWDKQFGFLKEILVAPASRKEAITGRIVGDSVMAVVQGLVILLLTFTIASSLKFSGVLPMILIGFLLAIAFSSFGVSLALRMTSMEGFQMIMSFLMLPLMFLSGAFYPVETMPTWMQYLAYINPLTYAVDAARHVLVNAPATTATAPIPGIPTVSLTRFSLMTDIGVLAVLALAFLAIAMISFERATIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN38</accession>
    <name>F0LN38_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate transport regulatory PgtC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467465.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01191"/>
    <dbReference type="EnsemblBacteria" id="ADT84167">
        <property type="protein sequence ID" value="ADT84167"/>
        <property type="gene ID" value="TERMP_01191"/>
    </dbReference>
    <dbReference type="GeneID" id="26136653"/>
    <dbReference type="KEGG" id="tba:TERMP_01191"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1194"/>
    <dbReference type="eggNOG" id="arCOG00221">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032622_0_0_2"/>
    <dbReference type="OMA" id="FYGYTAM"/>
    <dbReference type="OrthoDB" id="26557at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="467" mass="51780" checksum="B8DC56F8FD28C9E3" modified="2011-05-03" version="1">MKKGIALSLVLLFLVSIVSGCIGGGEQSTTATSTSKPSGGITLIVLTRHDTTIQMLAKEAFLKSDIAKKYNIVNIKFIKAPDSQWPALIKRGADIGWGGGPTLFDDLFKQGYLAPITDEKVLGLLGTQIKEDIAGMPMVRKGKDGKVYWIAAALSSFGFTVNKDVLKRWNLPMPEKWEDIASETFALDPPQVGIADPTRSTSNTRIYQIILQAFGWDEGWKVLTIIAANSKIYDASDAVREAVIAGDIAVGNTIDFYGYTAMKLNPACIYIIPKGESIINGDPIALLKNSQHPEAAQAFIYWVLTDGQKIWLNEDVNRLPVNPAVFDTPEGQKRPDLKKAYELALQTQGIQFDDARALATVYAMQFYFKATLVDANQELHRAWVALVQAYKQGKISKDKYEQLKAQLLAPIQFKDPDTGKMVTFTEDYAKKINERLIKDPGFKDTLMQEWRDAARAKYNKVLSEVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN52</accession>
    <name>F0LN52_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747413.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02218"/>
    <dbReference type="EnsemblBacteria" id="ADT85191">
        <property type="protein sequence ID" value="ADT85191"/>
        <property type="gene ID" value="TERMP_02218"/>
    </dbReference>
    <dbReference type="GeneID" id="10549042"/>
    <dbReference type="KEGG" id="tba:TERMP_02218"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2212"/>
    <dbReference type="HOGENOM" id="CLU_898994_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="309" mass="36446" checksum="C356E16DFD03B1D7" modified="2011-05-03" version="1">MKRVLVLETAWAEDYWESAKEAPYPKRSYKELKDWENLKKSLPLPGLGVYIKQTIKGKIHDYLHKPFVYLRVKGMKYNEKGEPHFDFEPIGKAKVKSEELLKRLPNKSALFFSISPKEIIQILEELGEKPPKEWLKLLEGEARGWNWKDWIGKYFSDIEEEELSNDEFEDRIADLLKAIGFNVIQKGHKLEGEFADGIAWIDNYYIVYDCKNRWNYTPTDSDIRAIKKYLEDEMKRNGEENRYYPVFIAKSVGMNIKKDVFCIPVNSLLYLLYKKLQLGPKFKLGPIKKILDDKNPLTIETIDKEWFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN73</accession>
    <name>F0LN73_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02239"/>
    <dbReference type="EnsemblBacteria" id="ADT85212">
        <property type="protein sequence ID" value="ADT85212"/>
        <property type="gene ID" value="TERMP_02239"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02239"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2233"/>
    <dbReference type="eggNOG" id="arCOG14123">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815396_0_0_2"/>
    <dbReference type="OMA" id="LAFEMKF"/>
    <dbReference type="OrthoDB" id="57016at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="424" mass="49811" checksum="2589A2E0F3E1A2CE" modified="2011-05-03" version="1">MGKAGGFDMPIPENILREHVLKAIEDIDRNGTPKNRRFRVWFLVYNGNRYPVKYVVELANKYVNGELLPSSEFTSHEAARYLEKLGFVVEYREKHISDGKNHKPARISKYSPLGEYLSKIAKDTVVLRFRDIERIIGKELPPAARTYKAWWANDKKHPQAVHGWLKAGWRIRHVDLRDEIVWFEKIQKNRIFPENKRFPPDEFDEKMYRVFEKFATLIEERLKAIAEGRSELEEIYQESEDTVRYMMFHSLTTVGGVDPTDVYLEYPHPQVPNKKYAKLDTFVAPKENRPALAFEMKFQKKIGNNAMPKPDNAGAVFADILKLALFRKEQGNIKRYFVYVADEHMVSYLSNPARGYEPFISLKENTGFKVTREYLIRKPVTFVRQLKRITEKEDFPEPTVICRFRRDLKLGNKEIAIRIYEVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN75</accession>
    <name>F0LN75_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type I site-specific deoxyribonuclease</fullName>
            <ecNumber evidence="3">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TERMP_02241</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="12 13">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
            <plasmid evidence="12 13">pTBMP1</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HsdR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747436.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02241"/>
    <dbReference type="EnsemblBacteria" id="ADT85214">
        <property type="protein sequence ID" value="ADT85214"/>
        <property type="gene ID" value="TERMP_02241"/>
    </dbReference>
    <dbReference type="GeneID" id="10549065"/>
    <dbReference type="KEGG" id="tba:TERMP_02241"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2235"/>
    <dbReference type="eggNOG" id="arCOG05724">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076815_0_0_2"/>
    <dbReference type="OMA" id="TNGIQWV"/>
    <dbReference type="OrthoDB" id="78811at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0614">Plasmid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="HSDR_N" evidence="11">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT85214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="343" mass="38591" checksum="FAC4EE9432B5E73E" modified="2011-05-03" version="1">MCEKTPMGITIKKVLDIAHSWATLYHSNEEATKQHLVLPILSALEWDIFNPEDVIPEVSTEEGGRVDYALYINGECIAYVEAKSLGVNIISDHNALSQLGKYCFSDGVQLGILTNGIQWVVINAFEPKKKLRDRLLIVIDLKRLPLEESIKRLSWLSKEKIKNVANIQERLVEIPQSDDSKLKESNPGSTRLIEKIPIRESSRIKTLEVEGIPVSTLNAPTIDELLYVDLKGKRPLSVYVKLSETWWRLEIVGGKRWGRSPRLKWSTLLPAVVVFLLQKGIDISNLHIPSKIDRLERIIPRSAGVIEIGNGFGVIMPGDGNSTVQFLKKIKQRTGIDVAIEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGU3</accession>
    <name>F0LGU3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-dependent glucose/glucosamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.147</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ADP-dependent glucokinase</fullName>
            <shortName evidence="3">ADP-GK</shortName>
            <shortName evidence="3">ADPGK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Glucosamine kinase</fullName>
            <shortName evidence="3">GlcN kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glkA</name>
        <name evidence="4" type="ordered locus">TERMP_00004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ADP + D-glucosamine = AMP + D-glucosamine 6-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62084"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58723"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ADP + D-glucose = AMP + D-glucose 6-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11460"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.147"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADP-dependent glucokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.147" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00004"/>
    <dbReference type="EnsemblBacteria" id="ADT82982">
        <property type="protein sequence ID" value="ADT82982"/>
        <property type="gene ID" value="TERMP_00004"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00004"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.4"/>
    <dbReference type="eggNOG" id="arCOG03370">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046643_0_0_2"/>
    <dbReference type="OMA" id="IHYIYEF"/>
    <dbReference type="OrthoDB" id="15153at2157"/>
    <dbReference type="UniPathway" id="UPA00109"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043843">
        <property type="term" value="F:ADP-specific glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00809">
        <property type="entry name" value="ADP_glucokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007666">
        <property type="entry name" value="ADP_PFK/GK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031299">
        <property type="entry name" value="GlkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208">
        <property type="entry name" value="PTHR21208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04587">
        <property type="entry name" value="ADP_PFK_GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51255">
        <property type="entry name" value="ADPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Glucose binding" evidence="3">
        <location>
            <begin position="120"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="352"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT82982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="466" mass="53057" checksum="FEAE62878A008F8A" modified="2011-05-03" version="1">MKESLKEKIRIWKSLYVNAFENATNALPGVRGVLLAYNTNIDALKYLDKEDLEERIEKVGKKRVFELMENPPEKVTSLEELFAGILRSIKLGKAMEWFVEDRGVRNYLREWGWDELRIGGQAGIMANLLGGVYRIPTIVHVPQNPKLQAELFVDGPIYVPVFDGEFKLVHPKEAVKENEEELIHYIFEFPRGFHVFDIVAPRENRFIANADDYNAKVYIRDEFKEHFNKIVKNVDLAIISGLQVLKESYEDGTTYRDVLNEVEAQLDMLNKRNVKIHFEFAYTANKKVRGALINLLPKFTSVGLNEVELASLMEIIGDEELAREVLEGNVFSVIDAMHLLMDETGIKRIHFHTYGYYVALTQYRGEEVRDALLFAALAAAAKAMYGSIENLSQIRDALSVPTNERAFLTEEELEKEFGEVENGIIDMTDRQLAFIPTKIVASPKSTVGIGDTISSSAFVSEFAMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGY3</accession>
    <name>F0LGY3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467489.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01215"/>
    <dbReference type="EnsemblBacteria" id="ADT84191">
        <property type="protein sequence ID" value="ADT84191"/>
        <property type="gene ID" value="TERMP_01215"/>
    </dbReference>
    <dbReference type="GeneID" id="10041532"/>
    <dbReference type="KEGG" id="tba:TERMP_01215"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1217"/>
    <dbReference type="eggNOG" id="arCOG02680">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110112_1_0_2"/>
    <dbReference type="OMA" id="KHERSFK"/>
    <dbReference type="OrthoDB" id="117224at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012041">
        <property type="entry name" value="Znf_CPxCG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42195">
        <property type="entry name" value="PTHR42195"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19769">
        <property type="entry name" value="CPxCG_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015877">
        <property type="entry name" value="UCP015877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="201" mass="23015" checksum="4524DBBAA7FFF197" modified="2011-05-03" version="1">MEFECPECGSENIEVIKERGREATLKCLDCGNVWIVTLPKLLRIPLIVSKHERSFKAEAELPEDEEIKVGDIVEIENDEVRITGIELEGNRRANKAKVSEVKTLWGESLRYPKIIGVSIYLPKGITQSFKVQVDRDEEFVVGEVLEVGGYTFKVEKIKTERKMLTHGKAKADKIVRLMGHQIRARASRKLKIYRGYESVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGZ2</accession>
    <name>F0LGZ2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01224"/>
    <dbReference type="EnsemblBacteria" id="ADT84200">
        <property type="protein sequence ID" value="ADT84200"/>
        <property type="gene ID" value="TERMP_01224"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01224"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1225"/>
    <dbReference type="eggNOG" id="arCOG08594">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180517_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="79" mass="9329" checksum="6E6F3961366A27C1" modified="2011-05-03" version="1">MLKKLPVEGYWLYGEYDFIAKIEFTDENELKEFSLELIRLIGSGKFKLFPVKLSSNALKNSAEKHQFNEIQEDSIFYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH23</accession>
    <name>F0LH23_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467529.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01255"/>
    <dbReference type="EnsemblBacteria" id="ADT84231">
        <property type="protein sequence ID" value="ADT84231"/>
        <property type="gene ID" value="TERMP_01255"/>
    </dbReference>
    <dbReference type="GeneID" id="10041572"/>
    <dbReference type="KEGG" id="tba:TERMP_01255"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1258"/>
    <dbReference type="eggNOG" id="arCOG03957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051317_0_0_2"/>
    <dbReference type="OMA" id="YITSAYF"/>
    <dbReference type="OrthoDB" id="80859at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01048">
        <property type="entry name" value="Ferritin_like_AB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019243">
        <property type="entry name" value="DUF2202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09968">
        <property type="entry name" value="DUF2202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2202" evidence="1">
        <location>
            <begin position="78"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="247" mass="27736" checksum="CD5543C7F336B481" modified="2011-05-03" version="1">MKKKLFGLMLVGVMLLTIAAGCLTTTETITQTITLTKTATQQPTNLENAGGAVTAPTGYQAVADLVSSYPVEELTQDEIDGILWMREEEKLARDVYLTLYEKWGLQIFYNIATRSEQTHMDMVLALIEKYNLTDPVGDNGIGEFTNPEIQALYDKLVAEGSKSVEDALKVGALIEEVDIKDLEEWLAKSDNEDIKFVYENLMMGSRNHLRAFVRNLENYGITYQPQVLPQDQYEQIINTPMEMGHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH29</accession>
    <name>F0LH29_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467535.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01261"/>
    <dbReference type="EnsemblBacteria" id="ADT84237">
        <property type="protein sequence ID" value="ADT84237"/>
        <property type="gene ID" value="TERMP_01261"/>
    </dbReference>
    <dbReference type="GeneID" id="10041578"/>
    <dbReference type="KEGG" id="tba:TERMP_01261"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1264"/>
    <dbReference type="eggNOG" id="arCOG03413">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047330_4_1_2"/>
    <dbReference type="OMA" id="WPTPDGY"/>
    <dbReference type="OrthoDB" id="75163at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="4">
        <location>
            <begin position="69"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="151" mass="17346" checksum="48796474A2442DF8" modified="2011-05-03" version="1">MIIPKFITDKVAFSPMPHPEEIAELAKEFQAVVVLTYEYELYYDLKEWEKHGVEVLYSPIEDFSAPTLEQLINIVRWIDEKVRDGKKVLIHCFGGSGRSGTIAVAYLMYSQGLSLRDALTRVRSLKPSAVETWSQMDILRKFERYLKGVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH60</accession>
    <name>F0LH60_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466320.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00044"/>
    <dbReference type="EnsemblBacteria" id="ADT83022">
        <property type="protein sequence ID" value="ADT83022"/>
        <property type="gene ID" value="TERMP_00044"/>
    </dbReference>
    <dbReference type="GeneID" id="10040363"/>
    <dbReference type="KEGG" id="tba:TERMP_00044"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.45"/>
    <dbReference type="eggNOG" id="arCOG05878">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071259_0_0_2"/>
    <dbReference type="OMA" id="DYPRPFM"/>
    <dbReference type="OrthoDB" id="71716at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="332" mass="39055" checksum="A7D20AEB35C88543" modified="2011-05-03" version="1">MRLLRFGPSLAFVRSSKLDELELFIENFFDAERMSVNEALKESWEFETIIVPTLSEEWKTYIENPNQEAFLVRMRCDSVLKELFNSKAPVERINLGPHIILFRVPKGAENAETLLASRYNGELVTLIEGIEKGEERDTLLVLTEKKLNTSIGLEDIKASLLFRKDFVAFYKMLSIDLPIIMHKVLPEGWNEITIRLYDNMKRYEENIERLLLVLEDLDLGYAVSEGWDWDYPRPFMRIRVYKIKLITWEDPLRIKFLLKGLEYRGYKRLADIDVFVEGKKLHWVDVAKRHDSKLELAKAAREELERLLSEDVKKKLHKIEAKLLQEGAHQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH79</accession>
    <name>F0LH79_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asparagine--tRNA ligase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466339.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00063"/>
    <dbReference type="EnsemblBacteria" id="ADT83041">
        <property type="protein sequence ID" value="ADT83041"/>
        <property type="gene ID" value="TERMP_00063"/>
    </dbReference>
    <dbReference type="GeneID" id="10040382"/>
    <dbReference type="KEGG" id="tba:TERMP_00063"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.63"/>
    <dbReference type="eggNOG" id="arCOG00409">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_2_2"/>
    <dbReference type="OMA" id="HSMILHK"/>
    <dbReference type="OrthoDB" id="80207at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="2">
        <location>
            <begin position="91"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="304" mass="34680" checksum="5AC25B11782A6C79" modified="2011-05-03" version="1">MNAVQLVKREIAPAMEVQTKIIEYMTRFFVGKGFKWLLPVMLSSITDPLWPDPAASEALKPPEIEAYGGKLRLMHSMILHKQLAVAMGIDKLFILSPNIRLEGREADDGRHAYEFTQLDFEIAYATMDDVMSLIEEAISGLFKEARKWEILEELGREVPKAKPPFKRFTLEEIKAEFGDEDKASEAMDEPFWITDIEREFYDREDPERPGHFRNYDLYLPWGYGEVSSGGEREWEYDIIVRKMKKAGISLEAFKPYLEVAKAGLLKPTAGAGIGMERLVRFIVGAKHIAEVQPFPRIPGIPAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH82</accession>
    <name>F0LH82_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="3">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466342.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00066"/>
    <dbReference type="EnsemblBacteria" id="ADT83044">
        <property type="protein sequence ID" value="ADT83044"/>
        <property type="gene ID" value="TERMP_00066"/>
    </dbReference>
    <dbReference type="GeneID" id="10040385"/>
    <dbReference type="KEGG" id="tba:TERMP_00066"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.66"/>
    <dbReference type="eggNOG" id="arCOG02199">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_1_0_2"/>
    <dbReference type="OMA" id="AGQFIIL"/>
    <dbReference type="OrthoDB" id="50646at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="278" mass="30907" checksum="E5F87C9E22F8BA6E" modified="2011-05-03" version="1">MFEILRKEKLAPGINLFEIKAERIAKKAKPGQFVILRLHERGERIPLTIADTNPEKGTVTIVAQEVGKTTHELGTYNVGDFILDFLGPLGKPSHIDRFGTVVMIGGGVGVAEIYPVAKAMKEAGNYVISILGFRTKELVFWEDKLKQVSDEVIVTTNDGSYGMKGFTTHALQKLIDEGRKIDLVHAVGPTIMMKFVAELTKPYGIKTVASLNPIMVDGTGMCGACRVTVGGEIKFACVDGPEFDAHQVNWDELMKRLDYYKDLEKISFEKWKRERGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH98</accession>
    <name>F0LH98_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA decarboxylase, gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466358.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00082"/>
    <dbReference type="EnsemblBacteria" id="ADT83060">
        <property type="protein sequence ID" value="ADT83060"/>
        <property type="gene ID" value="TERMP_00082"/>
    </dbReference>
    <dbReference type="GeneID" id="10040401"/>
    <dbReference type="KEGG" id="tba:TERMP_00082"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.82"/>
    <dbReference type="eggNOG" id="arCOG02699">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_5_2_2"/>
    <dbReference type="OMA" id="AMKMNTI"/>
    <dbReference type="OrthoDB" id="81675at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="74"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="153" mass="15821" checksum="EFA46181D693B959" modified="2011-05-03" version="1">MKGKVKVIVDGVTYEVEVEELGTGKFRVSFEGESYEVEAKDLGIPLSAVEMPAQVQAPSAPAPAPVTAPSPAVSAPVPAPVTGGGVVSAPMPGKVLRILVREGDEVKAGQGLLVLEAMKMENEIPAPKDGIVKKILIKEGDTVDTGQPLIEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH99</accession>
    <name>F0LH99_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methylmalonyl-CoA decarboxylase, beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_00083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466359.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00083"/>
    <dbReference type="EnsemblBacteria" id="ADT83061">
        <property type="protein sequence ID" value="ADT83061"/>
        <property type="gene ID" value="TERMP_00083"/>
    </dbReference>
    <dbReference type="GeneID" id="26135399"/>
    <dbReference type="KEGG" id="tba:TERMP_00083"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.83"/>
    <dbReference type="eggNOG" id="arCOG04475">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036168_0_0_2"/>
    <dbReference type="OMA" id="PMIADPK"/>
    <dbReference type="OrthoDB" id="32206at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005661">
        <property type="entry name" value="OadB_MmdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35806">
        <property type="entry name" value="PTHR35806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03977">
        <property type="entry name" value="OAD_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015658">
        <property type="entry name" value="MmdB_OadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01109">
        <property type="entry name" value="Na_pump_decarbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="374" mass="39020" checksum="8BA164101D9D1764" modified="2011-05-03" version="1">MGLEQAIIDFFAHMGLLNLTVGNVVMILVGLTLVYLAVVKGMEPLLLLPIGISAVLVNLPFTGIADPPHGLFYLIHRYLISTEVVPLLIFFGLGAMTDFGPMIADPKTALLGAAAQIGVFIAMLTAVALGFTLQEAASIGIIGGADGPTTIYLTTKLAPHLLGATAVAAYSYMSLVPLIQPPVIKALTTPEERKIRMEQLRPVSKREKILFPIASMLIIGLLVPSAAPLIGMLMIGNLFRESGVVERLSKAAREELMNIVTIFLGLGVGSTMRAEYFLTAKTLMILALGVIAFATATAGGVLLGKLMMKLSGGKINPMIGAAGVSAVPMSARVVQKLAAEEDPGNFILMHAMGPNVAGVIGTAVVAGVLLSALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHB5</accession>
    <name>F0LHB5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Protein translation factor SUI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466375.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00099"/>
    <dbReference type="EnsemblBacteria" id="ADT83077">
        <property type="protein sequence ID" value="ADT83077"/>
        <property type="gene ID" value="TERMP_00099"/>
    </dbReference>
    <dbReference type="GeneID" id="26135415"/>
    <dbReference type="KEGG" id="tba:TERMP_00099"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.100"/>
    <dbReference type="eggNOG" id="arCOG04223">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082805_6_1_2"/>
    <dbReference type="OMA" id="TIRDSWI"/>
    <dbReference type="OrthoDB" id="118816at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00604">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022851">
        <property type="entry name" value="SUI1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037511">
        <property type="entry name" value="Transl_init_SUI1_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01158">
        <property type="entry name" value="SUI1_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="98" mass="11432" checksum="660D5F4A1AB5DFFD" modified="2011-05-03" version="1">MPRIVNPLDEMLFKEVLKEQQRIKVYIERARYGKLKTIIEGIDEKEFDLEEIAKKLKAKLACGGTVKKGRIELQGDHREKVKQLLAEYGFSEDLIEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHH6</accession>
    <name>F0LHH6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01328"/>
    <dbReference type="EnsemblBacteria" id="ADT84303">
        <property type="protein sequence ID" value="ADT84303"/>
        <property type="gene ID" value="TERMP_01328"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01328"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1328"/>
    <dbReference type="eggNOG" id="arCOG00524">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094839_1_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="169" mass="19295" checksum="0D4B9A0D979E5DE3" modified="2011-05-03" version="1">MEMIRHIILLIPFSIGRKEMKVCIVYDTKRGSTGIIASWMGEAIKDVCDVRVMHIGEVNTLKDCDLIVIGSPIYYERPLKSVLEFLEQHQDELRNKKVAVFVVCIAEIFGHAGKAYAEKRYVGALIKRVPGKVIETAVIKGWIRKPNFSQKVVVQNWIKELLKNLEIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHJ8</accession>
    <name>F0LHJ8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Na(+) H(+) antiporter subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_01350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467623.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01350"/>
    <dbReference type="EnsemblBacteria" id="ADT84325">
        <property type="protein sequence ID" value="ADT84325"/>
        <property type="gene ID" value="TERMP_01350"/>
    </dbReference>
    <dbReference type="GeneID" id="10041666"/>
    <dbReference type="KEGG" id="tba:TERMP_01350"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1350"/>
    <dbReference type="eggNOG" id="arCOG03079">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101659_3_2_2"/>
    <dbReference type="OMA" id="LRWVESD"/>
    <dbReference type="OrthoDB" id="119875at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="8">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="140" mass="15540" checksum="D417FB5B08DF8AE9" modified="2011-05-03" version="1">MKMSTVVRTTTKLISPFLVTYAVYLMIYGHLSPGGGFQAGVVLAVSVILLITSHGYKKVRKRFKFKEVGMIENISAVFLVSLGLIGFMFGSFFYNFLIKGEFRSVMSGGIIPLFNIAVGLKVGAAFTFVFYILLRWVESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHK1</accession>
    <name>F0LHK1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Multisubunit sodium/hydrogen antiporter MnhG-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467626.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01353"/>
    <dbReference type="EnsemblBacteria" id="ADT84328">
        <property type="protein sequence ID" value="ADT84328"/>
        <property type="gene ID" value="TERMP_01353"/>
    </dbReference>
    <dbReference type="GeneID" id="26136837"/>
    <dbReference type="KEGG" id="tba:TERMP_01353"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1353"/>
    <dbReference type="eggNOG" id="arCOG03083">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121334_2_4_2"/>
    <dbReference type="OMA" id="ATKCDTG"/>
    <dbReference type="OrthoDB" id="105926at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="104" mass="11426" checksum="32B23D9089CF207D" modified="2011-05-03" version="1">MIEYMLLAFGEVVMVFGALGILRFPDVYTRLHAATKCDTGGAMTILLALALYTDASVFIKLKLLLLAFLIALINPMVSHAIAKGAYKYGIKPKVVVDMYAWDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHN7</accession>
    <name>F0LHN7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Isopentenyl phosphate kinase</fullName>
            <shortName evidence="10">IPK</shortName>
            <ecNumber evidence="3 10">2.7.4.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">TERMP_00144</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33963"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isopentenyl phosphate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.26" evidence="3 10"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466419.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00144"/>
    <dbReference type="EnsemblBacteria" id="ADT83121">
        <property type="protein sequence ID" value="ADT83121"/>
        <property type="gene ID" value="TERMP_00144"/>
    </dbReference>
    <dbReference type="GeneID" id="10040462"/>
    <dbReference type="KEGG" id="tba:TERMP_00144"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.145"/>
    <dbReference type="eggNOG" id="arCOG00860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070213_0_0_2"/>
    <dbReference type="OMA" id="HHNASEH"/>
    <dbReference type="OrthoDB" id="96284at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102043">
        <property type="term" value="F:isopentenyl phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04241">
        <property type="entry name" value="AAK_FomA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024192">
        <property type="entry name" value="Fosfomycin_R_FomA-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF1">
        <property type="entry name" value="PTHR43654:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016496">
        <property type="entry name" value="Kin_FomA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7 10 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="5"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADT83121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="266" mass="29790" checksum="C372FDCC9591EBD2" modified="2011-05-03" version="1">MIIIKLGGSVISDKEKEYSFHKYIVEQIAEEIAQFYPEENFILVHGGGSFGHPNAKEYKIPEGLVGNVDRKRIGFSKTHQAMLRLNDLIVQTFLEKGLPAYSVSSSSIFLIENKEIVYAELEILRKLLELKFIPILFGDTAIALDKGIGILSGDQIVSYLAKMLKPNKVIFLMDVDGIYNKNPRERDAKLIEELNAEEIRHLLESSESAGIDVTGGIGNKLREALKIAEHSEVYFINGKVRGNLGKAIKGQRVGTRLRKLEHPKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHS4</accession>
    <name>F0LHS4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466456.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00181"/>
    <dbReference type="EnsemblBacteria" id="ADT83158">
        <property type="protein sequence ID" value="ADT83158"/>
        <property type="gene ID" value="TERMP_00181"/>
    </dbReference>
    <dbReference type="GeneID" id="10040499"/>
    <dbReference type="KEGG" id="tba:TERMP_00181"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.182"/>
    <dbReference type="eggNOG" id="arCOG00717">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115769_0_1_2"/>
    <dbReference type="OMA" id="IECIALC"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021799">
        <property type="entry name" value="DUF3368"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11848">
        <property type="entry name" value="DUF3368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="157" mass="17586" checksum="98F0BBC898A66913" modified="2011-05-03" version="1">MSIVSNSSPLILLAKIGRFNLLKQYENVFIPNAVYIEVCIHGKSLPGSDEVKRAIHEGWIQIRKVKTLPELEFLLGRGEAEAITLAKSLNFPILIDDRKGRILARKMNLTVFGTLGVLVNAYNHGLIEDLESEVQKLVNAGIRISPVLLRKLMEEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHT9</accession>
    <name>F0LHT9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypA</name>
        <name evidence="5" type="ordered locus">TERMP_01364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467637.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01364"/>
    <dbReference type="EnsemblBacteria" id="ADT84339">
        <property type="protein sequence ID" value="ADT84339"/>
        <property type="gene ID" value="TERMP_01364"/>
    </dbReference>
    <dbReference type="GeneID" id="10041680"/>
    <dbReference type="KEGG" id="tba:TERMP_01364"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1364"/>
    <dbReference type="eggNOG" id="arCOG04426">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126929_2_0_2"/>
    <dbReference type="OMA" id="EDIHFIP"/>
    <dbReference type="OrthoDB" id="109617at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="138" mass="15818" checksum="8B5325880A04DC94" modified="2011-05-03" version="1">MHEWALADGIMRTAIEFAKQHGKDKILGIRIVLGELQDVNEEILKFAIDELKKGTIAEDAEIEFVIEEAEFKCRDCGNVWKLREVKDKFDERIKEDIHFIPEVVHVFLSCPKCGSRDFEVVKGRGVYVAAIKVEGEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHU3</accession>
    <name>F0LHU3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467641.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01368"/>
    <dbReference type="EnsemblBacteria" id="ADT84343">
        <property type="protein sequence ID" value="ADT84343"/>
        <property type="gene ID" value="TERMP_01368"/>
    </dbReference>
    <dbReference type="GeneID" id="10041684"/>
    <dbReference type="KEGG" id="tba:TERMP_01368"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1368"/>
    <dbReference type="eggNOG" id="arCOG03754">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_616270_0_0_2"/>
    <dbReference type="OMA" id="HEKEYYC"/>
    <dbReference type="OrthoDB" id="60571at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="444" mass="49963" checksum="FD21F7F8536D3F84" modified="2011-05-03" version="1">MRRLLALLVGLLILVALGYTQAAPIGGARLTLFDEKGKPLTDYGKVYYSIWTFDKNGSIEVLQKGTLTKNLLKSLIFPDNMIKLNLDTPRSIAKTKGSHTAFIGIDVWVVKDGKLYTFPPESFEVKVSKNTFAKNIMLKFNFKEARVKDLKALSSKASKIQPMAHDVYYVWETVEDKSYQHQKIPVLIVKNKAPSSISATIQMAYRGSYYLGPMVTVAFGDLISEKISFDPSSITVKALGRSVTKKYKASWIMDVSPYSSKYIWIKGTVHYIYQKEYLCTAWCYPTGNERYFVKIDSFDTDYYNGIYHIITGEASGEPPYDVPSRWIEQTGSVHNSKADIEDFYSEIYVGTSGESFNIGVPLGALIAFLNPETAPAWLDVIVAGFSLEDYVDYAVLGSVQSKNGNYLYFKGVKSAYEMKLPVKTWYGTTYRDTPVPIGFYIEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHV1</accession>
    <name>F0LHV1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467649.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01376"/>
    <dbReference type="EnsemblBacteria" id="ADT84351">
        <property type="protein sequence ID" value="ADT84351"/>
        <property type="gene ID" value="TERMP_01376"/>
    </dbReference>
    <dbReference type="GeneID" id="10041692"/>
    <dbReference type="KEGG" id="tba:TERMP_01376"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1376"/>
    <dbReference type="eggNOG" id="arCOG01972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_4_2"/>
    <dbReference type="OMA" id="WFSIPGC"/>
    <dbReference type="OrthoDB" id="110723at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="101" mass="11771" checksum="2EC8564CF697F8C0" modified="2011-05-03" version="1">MIVEYDGKINFMDGKAVLWFSIPGCPPCRIVESFMEELSAEFPEITVVHINAEEWNDLVNRFDVLNVPTLIYLKDGEEVARQNLIRGKEEVLIRFEELKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHV2</accession>
    <name>F0LHV2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lead/cadmium/zinc and mercury transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_01377</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467650.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01377"/>
    <dbReference type="EnsemblBacteria" id="ADT84352">
        <property type="protein sequence ID" value="ADT84352"/>
        <property type="gene ID" value="TERMP_01377"/>
    </dbReference>
    <dbReference type="GeneID" id="10041693"/>
    <dbReference type="KEGG" id="tba:TERMP_01377"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1377"/>
    <dbReference type="eggNOG" id="arCOG02763">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_11_2_2"/>
    <dbReference type="OMA" id="ITFFGWM"/>
    <dbReference type="OrthoDB" id="21472at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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        <property type="entry name" value="ATPase_P-typ_P_site"/>
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        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
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        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
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        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="747"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="72"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT84352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="801" mass="87848" checksum="5B3B87B143DE469F" modified="2011-05-03" version="1">MEVNIKITGMSCASCAKTIEMALKELEGVKEAKVNLATESAYIKFDESKVSITDIIRAIESVGYGVVREKRDAVIKIGGMTCASCVRTIETALKELPGVLDVRVNLATETANVTYDPTMVDMDDIKKTIEEFGYQFLGVEGEESVDIEKEVRERHLKDMKRKLIVAWTFGGIITFMTYRWIFGLDFEIPYMLWIQFLLATPVIAYSGRDVFLKAIRSLRHKTLNMDVMYSMGVGSAYIASVLATIGVLPKEYNFYEASVLLLAFLLLGRYLEHVAKGRTSEAIKKLMSLQAKKATVIRDGKEIEVPITQVKVGDIVIVKPGEKIPVDGVVIEGESYVDESMITGEPIPNLKKKGDEVIGGTINRNSVLKIKAERVGGDTVLAQIIKLVEDAQNTRPPIQRIADKIVTYFIPVVLTVALISFVYWYFIAKEPLLFAFTTLISVLVIACPCAFGLATPTALTVGMGKGAEMGILIKNGEVLEIARKATVVLFDKTGTLTKGKPEVTDVITFGMDEKELIKLVASAEKRSEHPLGEAIVRKAQELGLELEEPEEFEAITGKGVKAKVRGREILAGNRKLLREAGYPVEDIEGTLHKLEDEAKTAIIIAIDGEIAGVMGIADTIKENAKEAIEELHRMGKKVGMITGDNRRTANAIARQLNIDYVLAEVLPQDKANEVKKLQETGEVVIFVGDGINDAPALAQADIGIAVSSGTDIAMESGEIVLMRNDIRDVVKAIKLSQKTLSKIKQNFFWAMIYNIILIPIAAGALFPLFGIIFRPEWAAGAMAISSVSVVSNSLLLKRARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHW9</accession>
    <name>F0LHW9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467667.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01394"/>
    <dbReference type="EnsemblBacteria" id="ADT84369">
        <property type="protein sequence ID" value="ADT84369"/>
        <property type="gene ID" value="TERMP_01394"/>
    </dbReference>
    <dbReference type="GeneID" id="10041710"/>
    <dbReference type="KEGG" id="tba:TERMP_01394"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1394"/>
    <dbReference type="eggNOG" id="arCOG09749">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117970_0_0_2"/>
    <dbReference type="OMA" id="GMTDQTI"/>
    <dbReference type="OrthoDB" id="77688at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="201" mass="22814" checksum="4A07DFE7B5EC5BC9" modified="2011-05-03" version="1">MGLLSRFFGRKNPLDIPIDQLRENQIKLDMQIRKIEDEIAEIDAQIAALFQRAKEARSKSEELTIATKIKTLNRKKQSLQNTHAQLNKQLMLVANLLIIKENEAILKGTPTWELLRKMSPEELEKNLVSMQLDAQNLNENLNIMLGYTDQAIGAGVEFEEDEELAEIMRTIQAVKEGELEPESAAEKVTGEKDKGEEVVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHZ4</accession>
    <name>F0LHZ4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fe-S cluster assembly ATPase SufC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467692.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01419"/>
    <dbReference type="EnsemblBacteria" id="ADT84394">
        <property type="protein sequence ID" value="ADT84394"/>
        <property type="gene ID" value="TERMP_01419"/>
    </dbReference>
    <dbReference type="GeneID" id="26136915"/>
    <dbReference type="KEGG" id="tba:TERMP_01419"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1419"/>
    <dbReference type="eggNOG" id="arCOG04236">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_2"/>
    <dbReference type="OMA" id="VHIMEAG"/>
    <dbReference type="OrthoDB" id="44302at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="247" mass="27117" checksum="F1A379617B7C627F" modified="2011-05-03" version="1">MLKVEDLHVKVMDKEILRGITLSIGEGELHVVMGPNGSGKSTLALTIAGHPRYKVSSGRIIFAGRDITKMKPEERARNGIFLSFQHPVEVEGVKVLQFLQRVLKNLRGVDEVEAYEIIFNAVEELGFDSSILSRELNVGFSGGERKKLEMLQAYLVRPKLLILDEPDSGVDVDSLKVIAGVIAKLHSEGTAILLITHYGRILEYLNPQRVHVLKEGKLVASGGVELVKLIEEKGFAAVEENGTAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI28</accession>
    <name>F0LI28_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Probable thymidylate kinase</fullName>
            <ecNumber evidence="2 4">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tmk</name>
        <name evidence="6" type="ordered locus">TERMP_00205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2 4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466480.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00205"/>
    <dbReference type="EnsemblBacteria" id="ADT83182">
        <property type="protein sequence ID" value="ADT83182"/>
        <property type="gene ID" value="TERMP_00205"/>
    </dbReference>
    <dbReference type="GeneID" id="10040523"/>
    <dbReference type="KEGG" id="tba:TERMP_00205"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.205"/>
    <dbReference type="eggNOG" id="arCOG01891">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_1_3_2"/>
    <dbReference type="OMA" id="VMTREPG"/>
    <dbReference type="OrthoDB" id="114844at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="5">
        <location>
            <begin position="7"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="209" mass="23773" checksum="9F9A5A4DAD03ED46" modified="2011-05-03" version="1">MGIFIVIEGIDGAGKSTQAKLLAKWFEKRGYNVVLTKEPTDTAFGKLIRKLVLTGGREGIIDGAKISHEAEALLFAADRAEHVKKLIEPSLRTGKVVISDRYFYSSLAYQWARGLDLEWLINLNKFAIRPDLVILLDLPVKESMKRINGRQLKSEFDRIAELQKKVRENYLKLVEMFPEMKIVNALASIEDIHNDIVALVEHEILNKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI72</accession>
    <name>F0LI72_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA damage repair.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nre family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466524.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00249"/>
    <dbReference type="EnsemblBacteria" id="ADT83226">
        <property type="protein sequence ID" value="ADT83226"/>
        <property type="gene ID" value="TERMP_00249"/>
    </dbReference>
    <dbReference type="GeneID" id="10040567"/>
    <dbReference type="KEGG" id="tba:TERMP_00249"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.249"/>
    <dbReference type="eggNOG" id="arCOG04269">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039703_0_0_2"/>
    <dbReference type="OMA" id="PVGVWQI"/>
    <dbReference type="OrthoDB" id="17407at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02096">
        <property type="entry name" value="Nre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033167">
        <property type="entry name" value="Nre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006979">
        <property type="entry name" value="Nre_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006978">
        <property type="entry name" value="Nre_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38136">
        <property type="entry name" value="PTHR38136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04895">
        <property type="entry name" value="Nre_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04894">
        <property type="entry name" value="Nre_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nre_N" evidence="2">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Nre_C" evidence="3">
        <location>
            <begin position="297"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="410" mass="47818" checksum="40A47A694EE591D5" modified="2011-05-03" version="1">MMQLFNSRLCALCKGRKLLCGRPTCPILERFRVVKSVERIVNRREIFGSSPPSIFVGEFGYPRVRIGPLVPPIEGNTSYLDNPLKWENKTINDILKYRSLLVMGETKADVKVSKSQRILSEIQELAMSIRPVDSEILLKRKPILKVLPNEFAPPVGPKAELLDFELTENPRIPRKIDYVVSDELKAEEAIIKLYTWEFDEYYIIRLLSAGLLGISRKLVPTRWSITAVQDTIGKHLRKEILKYDTINEFELYFYEFLGNRYAVLLMPESYAFELLEVWLKGSLFGSEEPQVIHDYEDWRGIRGYAEETTGAYYAARLSVLEFLRNRKRQARILVFREVTPKYYAPVGVWQIRLGVKKALKNPVGKFDTLQEALNEVKKLLEHPLEKYLEKSWLLKMRKKQMTLDEFLKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI86</accession>
    <name>F0LI86_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467714.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01441"/>
    <dbReference type="EnsemblBacteria" id="ADT84416">
        <property type="protein sequence ID" value="ADT84416"/>
        <property type="gene ID" value="TERMP_01441"/>
    </dbReference>
    <dbReference type="GeneID" id="26136934"/>
    <dbReference type="KEGG" id="tba:TERMP_01441"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1441"/>
    <dbReference type="eggNOG" id="arCOG04823">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1044360_0_0_2"/>
    <dbReference type="OMA" id="FPPRKWP"/>
    <dbReference type="OrthoDB" id="53975at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="266" mass="30928" checksum="564DA5D4FC7D61FC" modified="2011-05-03" version="1">MFTKELIAEKVREIREKHGFENVPFFIDDVIYDSEGDKLFIIARDRSDKSAIIGNSFVIGKLKEELGVKQVTVYSKLDLLIKRKKVRENIERIKGTHLEFLNPILEAELNFPPRKWPELKNNGEALVFLSFNAKAMVGFAKKVGLTPVKVGIKYAFPKWEYEAIEGSPREVLFPDEDKLIEIAKERGLRIIISDFPFDLKFKENIALLNPLRFLHMGFFEAKYFFGFEKPVILDKRALIDFVVSYVYEGLMESTDGANLIWRGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI91</accession>
    <name>F0LI91_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467719.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01446"/>
    <dbReference type="EnsemblBacteria" id="ADT84421">
        <property type="protein sequence ID" value="ADT84421"/>
        <property type="gene ID" value="TERMP_01446"/>
    </dbReference>
    <dbReference type="GeneID" id="10041762"/>
    <dbReference type="KEGG" id="tba:TERMP_01446"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1446"/>
    <dbReference type="eggNOG" id="arCOG06145">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159747_0_0_2"/>
    <dbReference type="OMA" id="FGMQYYY"/>
    <dbReference type="OrthoDB" id="104785at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="127" mass="14202" checksum="33A06A619E287E8C" modified="2011-05-03" version="1">MGIIKKLVGGFFLLILIGIIGVFGMQYYYENAYDQVPVEVKSETVSGDVFYLSNVLEPGKYLIKAESEGTVEKIVILDDNGNVLTESETGKLIYGSSQRFQVRVDYKAPMNVDSYKVSVGIYRLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI93</accession>
    <name>F0LI93_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467721.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01448"/>
    <dbReference type="EnsemblBacteria" id="ADT84423">
        <property type="protein sequence ID" value="ADT84423"/>
        <property type="gene ID" value="TERMP_01448"/>
    </dbReference>
    <dbReference type="GeneID" id="10041764"/>
    <dbReference type="KEGG" id="tba:TERMP_01448"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1448"/>
    <dbReference type="eggNOG" id="arCOG07765">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057270_0_0_2"/>
    <dbReference type="OrthoDB" id="30578at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="258" mass="28269" checksum="E29FB38F2B6C50B3" modified="2011-05-03" version="1">MGKGTAILIVLLLLAAGYIYLSNPEVIDKVIDNAKNIKAPEKGQSESQVQEKGWSDTDGDESPDVYMGDGIDAIRVNSTYIIFADRNKDGKIDAIYLDTTGDGNYDTAYLDEDYNGRTDTWKTALNGVESYAWDVTGDGIPDLYDINGDGKVDAWDINSDGAIDERDIDFDGKPDLHDHDFDGTFDEFQGETDFAPPSNGTSACLATKDEAYRLFVNAYNNVTSLQQANASQEVLEEAYAKYLEARACYESFNSTSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIB5</accession>
    <name>F0LIB5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rubrerythrin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01470"/>
    <dbReference type="EnsemblBacteria" id="ADT84445">
        <property type="protein sequence ID" value="ADT84445"/>
        <property type="gene ID" value="TERMP_01470"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01470"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1470"/>
    <dbReference type="eggNOG" id="arCOG01104">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119858_1_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="106"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="166" mass="19554" checksum="A652B8C828D487C5" modified="2011-05-03" version="1">MDGDDVISNLRELDYKLVLSYWIKSENDLSKFYKELACKSKEVGLEEWAFDMFILLSEESKRVEKKLKEIYSRKFGSIDIEKLPDSPIKIPAYIKEFDNPHSILGILKSAIYCEELAENICQVLSQKAPTEYEKELFKYLASSERCHLRILTERFNYYKKKLKAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIF3</accession>
    <name>F0LIF3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0201 protein TERMP_01508</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0201 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01508"/>
    <dbReference type="EnsemblBacteria" id="ADT84483">
        <property type="protein sequence ID" value="ADT84483"/>
        <property type="gene ID" value="TERMP_01508"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01508"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1508"/>
    <dbReference type="eggNOG" id="arCOG01043">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134829_0_0_2"/>
    <dbReference type="OMA" id="VHKQVAY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01112">
        <property type="entry name" value="UPF0201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39652">
        <property type="entry name" value="PTHR39652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="139" mass="15996" checksum="E1E33953AFB4E081" modified="2011-05-03" version="1">MVREMFEEVEVEAYVYPTEDIEKVKKAMLNLIPGLEFEAFDKGDYIVLVGKTKNKKALQRLYELFRGQAILDTARAFLEDGYFGEEIIIKVHKQVAYAGKVNFNEESPLGPITITIRTKDPQRLMKWLAPRTKDGVPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIH2</accession>
    <name>F0LIH2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466544.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00269"/>
    <dbReference type="EnsemblBacteria" id="ADT83246">
        <property type="protein sequence ID" value="ADT83246"/>
        <property type="gene ID" value="TERMP_00269"/>
    </dbReference>
    <dbReference type="GeneID" id="26135610"/>
    <dbReference type="KEGG" id="tba:TERMP_00269"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.269"/>
    <dbReference type="eggNOG" id="arCOG04811">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095425_1_2_2"/>
    <dbReference type="OMA" id="FWLQQKG"/>
    <dbReference type="OrthoDB" id="115400at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="99" mass="10355" checksum="61914DD3515BE1E5" modified="2011-05-03" version="1">MEVNFGGIAGDIGVGGLVGFITGYALKKFIKLVLALIGAYVLSLFWLQQKGVITINTNALFNLTESAATQTLSLADKVMSILPGGGAFVVGFYLGFHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIJ1</accession>
    <name>F0LIJ1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxaloacetate decarboxylase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466563.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00288"/>
    <dbReference type="EnsemblBacteria" id="ADT83265">
        <property type="protein sequence ID" value="ADT83265"/>
        <property type="gene ID" value="TERMP_00288"/>
    </dbReference>
    <dbReference type="GeneID" id="10040606"/>
    <dbReference type="KEGG" id="tba:TERMP_00288"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.288"/>
    <dbReference type="eggNOG" id="arCOG02095">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_4_2_2"/>
    <dbReference type="OMA" id="GYHALEM"/>
    <dbReference type="OrthoDB" id="19729at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005776">
        <property type="entry name" value="OadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01108">
        <property type="entry name" value="oadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="517"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="593" mass="66473" checksum="D6DCB477E971BC7C" modified="2011-05-03" version="1">MVEIIDTTFRDAHQSLIATRMSTKDMLPIAEKMDRIGFYSMEVWGGATFDAALRFLREDPWERLRTLREHIKKTKLQMLLRGQNVVGYKHYPDDVVEKFVELAYKNGIDIFRIFDALNDVRNMKTAIKKAKEIGAEVQGAICYTTGPIFTVEYYMKKVDELIELDVDYITIKDMAALLDPQMAYELVKEIKERYGIKVNVHTHATSGLASATYLKAVEAGADLIDTAIYPLANGTAQPAIQTIYHALKESDKPQIDMKLVFQISRYLRKLLDEKYEHLMNKRALHGDPNVLLHQIPGGMYSNLIKQLSELKALDKLDEVLEEVPRVREELGYPPLVTPTSQIIGTQAVFNVLFGRYKMITEETKNYVRGLYGKPPAPIKEEIRKLILGDEEPITVRPADLLEPVLEKCRRELEEKGYLKKEEDILTYALFPQVALEFFELREKGELKPIEEKPKGKIIKIYIGGREYEVGIEGVKLENLVMPAISVQERAVQPTTSAPAPAPAPVTAPSPAVSAPVPARVSVGGGVVSAPMPGKVLRILVREGDEVKAGQGLLVLEAMKMENEIPAPKDGIVKKILIKEGDTVDTGQPLIEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIJ6</accession>
    <name>F0LIJ6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alanyl-tRNA synthetase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466568.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00293"/>
    <dbReference type="EnsemblBacteria" id="ADT83270">
        <property type="protein sequence ID" value="ADT83270"/>
        <property type="gene ID" value="TERMP_00293"/>
    </dbReference>
    <dbReference type="GeneID" id="10040611"/>
    <dbReference type="KEGG" id="tba:TERMP_00293"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.293"/>
    <dbReference type="eggNOG" id="arCOG01254">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_3_2_2"/>
    <dbReference type="OMA" id="LMRLHTA"/>
    <dbReference type="OrthoDB" id="60779at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="214" mass="25207" checksum="1E49F3AB1CD70663" modified="2011-05-03" version="1">MTKKLYYEDAYLKEAKAKVVEIKDNALLLDQTIFYPTGGGQPHDRGTINGVHVLDVYKDEEGNVWHVVEEPEKFRIGDEVELKIDWDYRYKLMRIHTAMHLLDHVLNEVLGKDKWQLYGSGMSVEKGRYDILYPENVNKYKEQIIERFNKYVDEGGEVKIWWEGEKRLTQIRDFEVLPCGGTHVKDIREIGHIKKLKRSSIGKGKQRLEIWLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIK0</accession>
    <name>F0LIK0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF402 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00297"/>
    <dbReference type="EnsemblBacteria" id="ADT83274">
        <property type="protein sequence ID" value="ADT83274"/>
        <property type="gene ID" value="TERMP_00297"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00297"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.297"/>
    <dbReference type="eggNOG" id="arCOG05760">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1465190_0_0_2"/>
    <dbReference type="OMA" id="LIYRRIP"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="72"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="184" mass="21550" checksum="D078236B24BE1360" modified="2011-05-03" version="1">MAEVFKPKIVNKTIMNKKVHLIYKRIPNRVLERYDELIADLGDIIVAKSKFHGMLAPLYVNGVKVIENDYTMIYFAFIGKNYDVLKVYDREGNFKGLYVDVLAYTERYGDTLEMLDLFLDIFIFPNGEAFLLDEDELEMALNYGLIDKDAFDFAYKVADEIIMAVKEKRFPPKIVWKYDLEGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIN2</accession>
    <name>F0LIN2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PduO-like Cob(I)alamin adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466604.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00329"/>
    <dbReference type="EnsemblBacteria" id="ADT83306">
        <property type="protein sequence ID" value="ADT83306"/>
        <property type="gene ID" value="TERMP_00329"/>
    </dbReference>
    <dbReference type="GeneID" id="10040647"/>
    <dbReference type="KEGG" id="tba:TERMP_00329"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.329"/>
    <dbReference type="eggNOG" id="arCOG00489">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083486_0_2_2"/>
    <dbReference type="OMA" id="HQACTVV"/>
    <dbReference type="OrthoDB" id="98914at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="4">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="174" mass="19732" checksum="0D65C08B983D4BB3" modified="2011-05-03" version="1">MPITTRTGDKGTTGIFTGERLAKFSPIIEANGTIDEASSFLGEAKHHIKDEELRGIVEKVQIDLYSLMAEIASKGKYKKIGEKEVEWMESLIKKFENEVQLKAFVIPGSTIASAKLDVCRAIVRRAERKVARLLLEYGFGEDALKYLNRLSDLLFIMARYIEWKEGKLRYAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIS4</accession>
    <name>F0LIS4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84526.1"/>
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        <property type="gene ID" value="TERMP_01551"/>
    </dbReference>
    <dbReference type="GeneID" id="10041867"/>
    <dbReference type="KEGG" id="tba:TERMP_01551"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1551"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1140604_0_0_2"/>
    <dbReference type="OMA" id="PVRQMIR"/>
    <dbReference type="OrthoDB" id="60415at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016757">
        <property type="entry name" value="UCP019322"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09883">
        <property type="entry name" value="DUF2110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019322">
        <property type="entry name" value="UCP019322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="243" mass="28092" checksum="4BCE33ABEB74051D" modified="2011-05-03" version="1">MKELVILEKIYGDRSGFEKLDRKLKSLIGDLEVTWKIGITQKQWVKIRIEGEDEEISANLIREEFGEVPYKLSNVKEGQRYKGRFIDLGKVGYGVYVDIGVFSPTPKDALMPLYYLKREFEEKPVRQMIREFGWIDYLPVEIQIEKVEFGTREVEAYFTDRQLKKMKSWISDGYDKLFIVGTVSEKVEDALIKTGHSRDVKKLEELGLMETLLILKRGTQAPGIIKEIGPYIKSAVIGAIKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIS5</accession>
    <name>F0LIS5_THEBM</name>
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        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84527">
        <property type="protein sequence ID" value="ADT84527"/>
        <property type="gene ID" value="TERMP_01552"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01552"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1552"/>
    <dbReference type="eggNOG" id="arCOG05847">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_881722_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="315" mass="35816" checksum="DFD89ED05B723170" modified="2011-05-03" version="1">MVVIIQAAVALTYISQSIANLISRYPDTAPLAVVSLLLIVLAVLAYGLFKESRHAFVLYLLVIILSLLWFSNSTQFKEKFLFFDPFFSSLVHFLLLVLLSGFIFYLAPRQSRELGFLIYGLVFASPTFREVVKSLDREFFAVFFFVITLSFVMNFSFTPRTFKAALETSLLTLFTVLSIGSNVYFSAILPAFILSFPKRHKRNYAYIGLSSIGVILLFYITGQHIFLRAPNKFHLYTIGTFGKEAFVPLILIGYLFATNFRIAIRMKGHTLFLLILSIFYLLLLTFDQTLFAPLVIIVSALSIRLTQKLYVATQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIW3</accession>
    <name>F0LIW3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Putative toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ordered locus">TERMP_01590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467863.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01590"/>
    <dbReference type="EnsemblBacteria" id="ADT84565">
        <property type="protein sequence ID" value="ADT84565"/>
        <property type="gene ID" value="TERMP_01590"/>
    </dbReference>
    <dbReference type="GeneID" id="10041906"/>
    <dbReference type="KEGG" id="tba:TERMP_01590"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1590"/>
    <dbReference type="eggNOG" id="arCOG00710">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134210_1_1_2"/>
    <dbReference type="OMA" id="DRYAWVY"/>
    <dbReference type="OrthoDB" id="88061at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="155" mass="17552" checksum="DBE9AC0A3AE8951A" modified="2011-05-03" version="1">MSHSEVFVDSSVLVGLNLGDEKAKALVKSLIERGFTLVINPVVFSETAYKVMFTLALRDGLKGVYDLKKHLDRYAWVYGKVKESIEQLIKNELLRVVEVNWEILKLSAEIGEKYALLTNDAIIVATCKYYGIQKIATFDEDFKKVDFLEVIDSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIY8</accession>
    <name>F0LIY8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FeS_assembly_P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466632.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00357"/>
    <dbReference type="EnsemblBacteria" id="ADT83334">
        <property type="protein sequence ID" value="ADT83334"/>
        <property type="gene ID" value="TERMP_00357"/>
    </dbReference>
    <dbReference type="GeneID" id="26135701"/>
    <dbReference type="KEGG" id="tba:TERMP_00357"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.357"/>
    <dbReference type="eggNOG" id="arCOG01856">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163804_0_0_2"/>
    <dbReference type="OMA" id="TPECHFC"/>
    <dbReference type="OrthoDB" id="107731at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="115" mass="13495" checksum="ED06D89F70FB204C" modified="2011-05-03" version="1">MRLFGFLKRKDTRDVKRKELPEDVKRVVEILKRVRDPETDLNIVDEGLVYGVTIEGKKAQIFLFMARSTPECHFCQMMAINVQRRILRDIINVLKQEGFNKVEVYNEIGLLLEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ16</accession>
    <name>F0LJ16_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466660.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00385"/>
    <dbReference type="EnsemblBacteria" id="ADT83362">
        <property type="protein sequence ID" value="ADT83362"/>
        <property type="gene ID" value="TERMP_00385"/>
    </dbReference>
    <dbReference type="GeneID" id="25394625"/>
    <dbReference type="KEGG" id="tba:TERMP_00385"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.385"/>
    <dbReference type="HOGENOM" id="CLU_2695953_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="73" mass="8163" checksum="972047B3B95436B1" modified="2011-05-03" version="1">MKGTPFPTEQVGKILGLQRKGLVVFEKGTFDGDSIVLYVLCEDSLPSEVISTVREVYRGSIFSLVLLFKRKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ46</accession>
    <name>F0LJ46_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homoserine kinase</fullName>
            <shortName evidence="5">HK</shortName>
            <shortName evidence="5">HSK</shortName>
            <ecNumber evidence="5">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">thrB</name>
        <name evidence="8" type="ordered locus">TERMP_00415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466690.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00415"/>
    <dbReference type="EnsemblBacteria" id="ADT83392">
        <property type="protein sequence ID" value="ADT83392"/>
        <property type="gene ID" value="TERMP_00415"/>
    </dbReference>
    <dbReference type="GeneID" id="10040733"/>
    <dbReference type="KEGG" id="tba:TERMP_00415"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.415"/>
    <dbReference type="eggNOG" id="arCOG01027">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_1_1_2"/>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="OrthoDB" id="91752at2157"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="75"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="7">
        <location>
            <begin position="198"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="295" mass="31065" checksum="F6A6E8D9B5BE93E8" modified="2011-05-03" version="1">MKVSAPATIANFGPGFDVFGLCLDEPRDVIKVKESDEVMVEVEGFNVPEDPEKNVASISALALLKMLKAEMGFRMKIIKGIRPKSGLGSSGASALGGALALAKLLGVENRELIIKAALEGEKAASGSAHGDNIVPSLFGGFTILKSLSPLEVFKLDVSFKLVIVLPKVEVSTKRARAVLPRYVPLSDAVRNLALASALISALKEGDIEKAGKLLDDYLAIPYRKPLIPWFDNVRRAALESGAYGVSLSGSGPAMFALGEDLGDIGKAMVEAFENEGIGAEYFITKVGGGAKCSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJC1</accession>
    <name>F0LJC1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467941.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01668"/>
    <dbReference type="EnsemblBacteria" id="ADT84643">
        <property type="protein sequence ID" value="ADT84643"/>
        <property type="gene ID" value="TERMP_01668"/>
    </dbReference>
    <dbReference type="GeneID" id="10041984"/>
    <dbReference type="KEGG" id="tba:TERMP_01668"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1667"/>
    <dbReference type="eggNOG" id="arCOG04469">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043916_0_0_2"/>
    <dbReference type="OMA" id="FVGCAML"/>
    <dbReference type="OrthoDB" id="112841at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002823">
        <property type="entry name" value="DUF112_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01970">
        <property type="entry name" value="TctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="385" mass="42415" checksum="D9FE7033516B49CE" modified="2011-05-03" version="1">MLREFLFGLIAGTITGITPALHVNTLASLLNALNNEPDGFGFVILIYTMGLTHTFLDSIPSTFLGVPDEDTVLNILPAHRLVLEGRALEVINISLRASLLAVIFAFPLLPIYLSLAPNYTPGFGRVFVFFLTCFLLLIEKGIKKVFALLVFLISGILGILIDYLPLREPYFHIFVGLFGVPTIFYSLRSGITTIEAGDYEIKMSHKSLFGFSLLGTTLGMLASLLPAFTSSQAALIGSFFSRDERSFLTVAFSVNTSNFFFSLFNFYLTGRTRNGIMVLIKEKYYLLSSHEILILTLLTIAAALIISLYGLEIAKIIGSVLFKVNYKLLNFLVLSFIVVLSLYFDGILGILLLATASLIGSLPLLLNIKRTNCMGVLMVKIMVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJE7</accession>
    <name>F0LJE7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisH</name>
        <name evidence="11" type="ordered locus">TERMP_00436</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466711.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00436"/>
    <dbReference type="MEROPS" id="C26.965"/>
    <dbReference type="EnsemblBacteria" id="ADT83413">
        <property type="protein sequence ID" value="ADT83413"/>
        <property type="gene ID" value="TERMP_00436"/>
    </dbReference>
    <dbReference type="GeneID" id="26135778"/>
    <dbReference type="KEGG" id="tba:TERMP_00436"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.436"/>
    <dbReference type="eggNOG" id="arCOG00089">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071837_2_2_2"/>
    <dbReference type="OMA" id="WVYFVHS"/>
    <dbReference type="OrthoDB" id="100772at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="35"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="196" mass="21695" checksum="4C7CDE9575A3F238" modified="2011-05-03" version="1">MIAIVDLGIGNLANVRKALGGVITSDPYEIEKAEKIVLPGVGNFGAVMEKLEPLRGVILDAINDGKPFLGICLGLQLLFEESEESPGSRGLGVFEGKVVRFRGVRTPHIGWNQVWQKKECRLFEGIKDGAYFYFVHSYYADPQDENIVAGVTDYQSKGNEVIFTSAVCKDNVYAVQFHPEKSSRVGLKLLANFRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJE9</accession>
    <name>F0LJE9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Histidinol dehydrogenase</fullName>
            <shortName evidence="6">HDH</shortName>
            <ecNumber evidence="6">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hisD</name>
        <name evidence="8" type="ordered locus">TERMP_00438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466713.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00438"/>
    <dbReference type="EnsemblBacteria" id="ADT83415">
        <property type="protein sequence ID" value="ADT83415"/>
        <property type="gene ID" value="TERMP_00438"/>
    </dbReference>
    <dbReference type="GeneID" id="10040756"/>
    <dbReference type="KEGG" id="tba:TERMP_00438"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.438"/>
    <dbReference type="eggNOG" id="arCOG04352">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_3_3_2"/>
    <dbReference type="OMA" id="MVTGPGN"/>
    <dbReference type="OrthoDB" id="55330at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="377" mass="42234" checksum="7F6A08F87FA64736" modified="2011-05-03" version="1">MNLELESYVAQILKDIRERGIEAVKEYSRKFDGYDGEFLVSEKEFEEAERQIPEKDKEIIKRTIERIRFYHEKQLESDKLYIKNASLYGIIYKPIRRIGIYVPGGKPLPSTLIMAGVPAKVAGVKEIAVTTPPKNGKINPYILYVAKLLGIEEVYKLGGIQAIGAMAYGIGMKKVDKIFGPGNRFVNEAKRQVFGVVGIDSLAGPSEIAVIADETANKEYVLYDLLSQLEHGKGSKAWLLTTSKELAEYCRKNGIEVVVCESLEECAEKANEIAPEHLEIITKEPLKLVDLIENAGAIYLGEYTPVPAADYFLGVNHVLPTGGAAKFSGVLTVMDFMKRISLAYVSREEFLSERYLGIRLAEIEGMEMHRKSMEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJI2</accession>
    <name>F0LJI2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRISPR-associated endoribonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00471</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466746.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00471"/>
    <dbReference type="EnsemblBacteria" id="ADT83448">
        <property type="protein sequence ID" value="ADT83448"/>
        <property type="gene ID" value="TERMP_00471"/>
    </dbReference>
    <dbReference type="GeneID" id="10040789"/>
    <dbReference type="KEGG" id="tba:TERMP_00471"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.471"/>
    <dbReference type="eggNOG" id="arCOG04342">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089858_1_1_2"/>
    <dbReference type="OMA" id="FGMVKVD"/>
    <dbReference type="OrthoDB" id="59332at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010156">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045747">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36984">
        <property type="entry name" value="PTHR36984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01881">
        <property type="entry name" value="Cas_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005054">
        <property type="entry name" value="PF1131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01877">
        <property type="entry name" value="cas_cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005054-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005054-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="242" mass="28379" checksum="C05FEA79D272CCBC" modified="2011-05-03" version="1">MRFLIRLRNENLEFKVPYNHLYYLQGLVYRRIQRVNPELSLSLHRPKVPKLFTFSLFMTKERHRMSGNNKYFIGRKEAFFYFSTAVPEIAEAFIGGLLQEPEVKLWGERFYVETVKALPEPISFSGKIYSTLSPIAVTTVKMQFGKPRHYDLGPDEPEFYENLKENLKQKYLLIYGKKPPEDFEIEVLSAKPKRFEVKPGIFQRAWHLIFRAYGDDELIRAGYLAGFGEKNSLGFGMVKVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJI4</accession>
    <name>F0LJI4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466748.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00473"/>
    <dbReference type="EnsemblBacteria" id="ADT83450">
        <property type="protein sequence ID" value="ADT83450"/>
        <property type="gene ID" value="TERMP_00473"/>
    </dbReference>
    <dbReference type="GeneID" id="10040791"/>
    <dbReference type="KEGG" id="tba:TERMP_00473"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.473"/>
    <dbReference type="eggNOG" id="arCOG10383">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_820447_0_0_2"/>
    <dbReference type="OMA" id="YEDIAMA"/>
    <dbReference type="OrthoDB" id="30525at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="338" mass="38349" checksum="EA1F52C684AC8EE8" modified="2011-05-03" version="1">MNRYLVPKQGWQFLDLAKAYGVGIIIYALSGDAEISDAGAYYEVRTQKELDFSRIPKIQEYIGDDLEEWGYVLATLNKAKVEKLKQEIRKFFSDENNVKKLLSGHLGGKSVTLPQSLELAASKGIRKAVLSSYSEDQVKILQDEFYLAVLGAINVSLWKYSKEYWVAVYPLPSNTKIRHIYTIRSKLKDSVKGFHRAGYFATVAYIATRLVKEEKALSNGRKFSPKIGGLLYGVMMKTGNQPKPFTSGLFPLDLLHTIVVSNEDALDMWLKIFEFTSFKKGYEDLALSLAKFIAEPTLDNYYSYARLHLRNELKKEGLKFGVYDADSLLEVLKNVEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJI7</accession>
    <name>F0LJI7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISPR-associated protein Cas5 family. Subtype I-A/Apern subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466751.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00476"/>
    <dbReference type="EnsemblBacteria" id="ADT83453">
        <property type="protein sequence ID" value="ADT83453"/>
        <property type="gene ID" value="TERMP_00476"/>
    </dbReference>
    <dbReference type="GeneID" id="10040794"/>
    <dbReference type="KEGG" id="tba:TERMP_00476"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.476"/>
    <dbReference type="eggNOG" id="arCOG02672">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1232816_0_0_2"/>
    <dbReference type="OMA" id="EQINPYS"/>
    <dbReference type="OrthoDB" id="79260at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010153">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5a-typ"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01874">
        <property type="entry name" value="cas_cas5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="224" mass="25693" checksum="CA3B10AF28B3B5FD" modified="2011-05-03" version="1">MKWLRLRIHFPSFYSYRIPDYSSQYALALPLIAPSTIKLALVATAIRISGKVSEGKRIFEYVKDAKVGIKLPKIIVVNSVFIKRLKKRKDQPGFQSSFGVREYVHFSGDLEIYLGFSKIGIPKELIIYAQSIRYLGTSDSLVYVKSVEWVDKEPADAIFPSELSKLPEGAIIYPVKDFAKKVTFEQINPYSSKKAGRPYEIKYYPILLSKRPREGKNWKLFVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJN9</accession>
    <name>F0LJN9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <shortName evidence="10">AdoMetDC</shortName>
            <shortName evidence="10">SAMDC</shortName>
            <ecNumber evidence="10">4.1.1.50</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="10">S-adenosylmethionine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">S-adenosylmethionine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="10" type="primary">speH</name>
        <name evidence="11" type="ordered locus">TERMP_01706</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="10"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467979.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01706"/>
    <dbReference type="EnsemblBacteria" id="ADT84681">
        <property type="protein sequence ID" value="ADT84681"/>
        <property type="gene ID" value="TERMP_01706"/>
    </dbReference>
    <dbReference type="GeneID" id="26137093"/>
    <dbReference type="KEGG" id="tba:TERMP_01706"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1705"/>
    <dbReference type="eggNOG" id="arCOG00279">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125470_2_3_2"/>
    <dbReference type="OMA" id="HTWPEKG"/>
    <dbReference type="OrthoDB" id="106151at2157"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006557">
        <property type="term" value="P:S-adenosylmethioninamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00464">
        <property type="entry name" value="AdoMetDC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042286">
        <property type="entry name" value="AdoMetDC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042284">
        <property type="entry name" value="AdoMetDC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="PTHR33866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="SSF56276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 10" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023260680" description="S-adenosylmethionine decarboxylase beta chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023260681" description="S-adenosylmethionine decarboxylase alpha chain" evidence="10">
        <location>
            <begin position="63"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="10">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="10">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="10">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="10">
        <location>
            <begin position="62"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="10">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT84681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="138" mass="15511" checksum="C6973D3B58989B2A" modified="2011-05-03" version="1">MDTIGYHYVVEASGCDPEILSDANKIREIFLKAAEAGNMEVKASYFFKFSPTGVSGMVIVAESHISIHTWPEKGYAAIDVYTCGEKADPEKAVDYILDAIKAEYAHVSEVKRGIEEDDSTFTHMILTWEEKLERKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJR2</accession>
    <name>F0LJR2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">2-(3-amino-3-carboxypropyl)histidine synthase</fullName>
            <ecNumber evidence="3 6">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DPH1/DPH2 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01729"/>
    <dbReference type="EnsemblBacteria" id="ADT84704">
        <property type="protein sequence ID" value="ADT84704"/>
        <property type="gene ID" value="TERMP_01729"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01729"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1728"/>
    <dbReference type="eggNOG" id="arCOG04112">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037146_0_0_2"/>
    <dbReference type="OMA" id="PGQVLGC"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022428">
        <property type="entry name" value="Dph2_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="PTHR10762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03682">
        <property type="entry name" value="arCOG04112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="358" mass="40110" checksum="3E14119034A670FF" modified="2011-05-03" version="1">MWSKLLHRGVKVSILHEIPFQEILQKIRELNAKKVLIQTPEGLKKEAQALAEFLGKNGVEAIISGDINYGACDLADREAKMLGCDALIHLGHSYMQLNLEVPTLFVPAFAKVDVVKALEKNLNEIKKLGRKIALVTTVQHIRDLERAKQFLEGKGFRVFIGKGDNRVSFAGQILGCNFTAARVGRDVDGILLIGAGYFHPIGVALATKKPTLAINPYSGDFSWVNTERIVRKRWGMVAKAYDAKKFGVIISTKRGQLRLGEAKRIMKLLKEHGREAQLIAMNYISPEALEGFDFDAYVVVACPRVPIDDAERWRKPILTPPEVELLLGLREEYEFDEILGGKREKDEPFGISLKLPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJS2</accession>
    <name>F0LJS2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_01739</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468011.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01739"/>
    <dbReference type="EnsemblBacteria" id="ADT84714">
        <property type="protein sequence ID" value="ADT84714"/>
        <property type="gene ID" value="TERMP_01739"/>
    </dbReference>
    <dbReference type="GeneID" id="10042055"/>
    <dbReference type="KEGG" id="tba:TERMP_01739"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1738"/>
    <dbReference type="eggNOG" id="arCOG00894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039727_0_0_2"/>
    <dbReference type="OMA" id="TAYIHGF"/>
    <dbReference type="OrthoDB" id="96698at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="7">
        <location>
            <begin position="3"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="8">
        <location>
            <begin position="235"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="354" mass="40661" checksum="B831871585999BC0" modified="2011-05-03" version="1">MISIIVPTYNERENLEELVSRISKALEDYEFEIIIVDDDSPDKTWEKAQELAQKYPIRVIRRTKEKGLSSAVIRGFKEARGDIFVVMDADLQHPPEVIPRLVEAIERGADIAIGSRYVKGGKVENWYWWRKLISKGAIMIGRVALPKIRNIKDPVSGFFALRRGIVENVELNPVGFKILLEILIKGKYSRVVEVPYAFGLRHAGESKLSQKQIFNYLRHLYRLMKWEGEIDRLIKFSIVGMSGIVVNQFFLWLFANILGGGIANLMIANVFATELAILNNFTWNDLWTFKDLKNKPLYKRLFSFHLAALTGAVVQWTIFGVLIFLGMHYLIANLIGIGFSFIVRFLVNRHITWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJS8</accession>
    <name>F0LJS8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468017.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01745"/>
    <dbReference type="EnsemblBacteria" id="ADT84720">
        <property type="protein sequence ID" value="ADT84720"/>
        <property type="gene ID" value="TERMP_01745"/>
    </dbReference>
    <dbReference type="GeneID" id="10042061"/>
    <dbReference type="KEGG" id="tba:TERMP_01745"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1744"/>
    <dbReference type="eggNOG" id="arCOG02408">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100862_1_1_2"/>
    <dbReference type="OMA" id="PIILKAK"/>
    <dbReference type="OrthoDB" id="88507at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002790">
        <property type="entry name" value="CHP00288"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00288">
        <property type="entry name" value="TIGR00288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="31"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="185" mass="20679" checksum="C5D4E632098824D2" modified="2011-05-03" version="1">MPSNWERIMAITKEGMRSIAMMKRKMRRGKKIALLIDGPNILRKEFNIHLEDIVEALEQLGNIRVAKVILNQYAPQGLIEAVANQGFEPIIVPGETGVKLAVEAMREIYNPNIDIIALATRNAEFLPIILKAKEKGKETVIIGVEPGFSAALKHGADYVIVLTPRGEESGERKDIQNSKERRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJX2</accession>
    <name>F0LJX2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00532"/>
    <dbReference type="EnsemblBacteria" id="ADT83509">
        <property type="protein sequence ID" value="ADT83509"/>
        <property type="gene ID" value="TERMP_00532"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00532"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.533"/>
    <dbReference type="eggNOG" id="arCOG02491">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703259_0_0_2"/>
    <dbReference type="OrthoDB" id="44507at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="392" mass="45416" checksum="F2D83CFC223DC9A5" modified="2011-05-03" version="1">MKSWVKSFLGSFILLSVISLVGYYDYIKSQAYLNDPLWSLDKFTTGGFIRGNFYGDKLVVVETNLSRFSNEGSVVMLFSKRGELLGKFKTEFKVYSFVVANDTLFVSESKILDIKGSTVYTQNFVSAYSLDGKLLWRRNISAFALAYSNGRIFGIDKGNIFALDNSGNLLWKKTIEGNPYRMLSCEKLIIVSTENMKRYEVPAFSPSGNFLWKLENDVSALDTNCHYILMRGSNWYGLFDMNGNELWIKEVSPKNQVIFKKDGISFYNFYAHIDRNGNVYLSEADSFTILDTNGKVIAYYNMPIGYFQISPDGRLIFDEYHVFVNPLYDRDHDKIPDDEDVFPLNNELLHQLFSAFGISFIFASLYEWRKKKEGRKAHEEYLRLKRELERRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJX3</accession>
    <name>F0LJX3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466808.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00533"/>
    <dbReference type="EnsemblBacteria" id="ADT83510">
        <property type="protein sequence ID" value="ADT83510"/>
        <property type="gene ID" value="TERMP_00533"/>
    </dbReference>
    <dbReference type="GeneID" id="10040851"/>
    <dbReference type="KEGG" id="tba:TERMP_00533"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.534"/>
    <dbReference type="eggNOG" id="arCOG00557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_0_0_2"/>
    <dbReference type="OMA" id="VVDEWHE"/>
    <dbReference type="OrthoDB" id="995at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045628">
        <property type="entry name" value="Lhr_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19306">
        <property type="entry name" value="Lhr_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="41"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="275"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="863" mass="99554" checksum="A62ED8C2038A3753" modified="2011-05-03" version="1">MIRFAQREYTDEEIYEILADPVREWFRGKFGTFTPPQRYAVIEIHKGENVLISSPTGSGKTLSAFLAAINELILLGKEGKLEDKIYVLYVSPLRALNNDIRRNLEEPLREIREVAHEMGYDLPEIRVAVRTSDTSSYEKQKMVKKPPHILITTPESLAIALNAPKFSERLKTVKYVIVDEVHALAENKRGTHLMLSLERLQNLAGDFVRIGLSATIHPLEEVAKFVFGFNDDGTPRSGLIVDVSFAKKTEIKVESVVGDLVYTDAATLSEALYKRLDELIEQHRTTLIFTNTRSGAERVAYHLKKKFPKYAELIEAHHSSLSRDVRLEVEEKLKKGELRCVVSSTSLELGIDIGSIDLVVLIGSPKSVNRALQRIGRAGHRLHEVSKGIILVLDRDDLVECTVLAYNARNRRLDRIKIPQNPLDVLVQHLLGMALEKVWDINEAYKLVRRAYPYHNLSFEDFMSVLRYLAGEYAGLEEKKVYAKIWLDEKEGKFGRRGKMTRAIYYMNTGTIPDEAKIEVYTLDRRFIGTVEEEFAERLMPGDIFVLAGRTYEFKKSRGNRIYVEPKEGAKPTIPAWFSEMLPLSFDLALDVQRFRKEVKELLNNPKAEQILMEKYRIDEKAAKAILGYFREQAKYSTIPDDGILLVEEVLEERRAKYFFHTLIGRRANEALSRAFAYLVSKKKRCNVGIAISDNGFMLILPREKRLSEEDIRTLFQLEDLRETLKKALDNTELLKRRFRHVANRGLLILRRYMGRKKSLSRQQLNAQTLLRLLKKNYPDFPLLKEVYREIMEDKMDIKNAELFLSWVKEGKIKIVFEQNELPSPFAFNLEIIGASDVVLMEDRRELIKQLHRKIMAMIGELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJY5</accession>
    <name>F0LJY5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Probable cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cobD</name>
        <name evidence="13" type="ordered locus">TERMP_00545</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 12">Cell membrane</location>
            <topology evidence="3 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466820.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00545"/>
    <dbReference type="EnsemblBacteria" id="ADT83522">
        <property type="protein sequence ID" value="ADT83522"/>
        <property type="gene ID" value="TERMP_00545"/>
    </dbReference>
    <dbReference type="GeneID" id="10040863"/>
    <dbReference type="KEGG" id="tba:TERMP_00545"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.546"/>
    <dbReference type="eggNOG" id="arCOG04274">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054212_0_2_2"/>
    <dbReference type="OMA" id="NSGYTMA"/>
    <dbReference type="OrthoDB" id="101304at2157"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT83522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="292" mass="33523" checksum="5F3A263F439F90B6" modified="2011-05-03" version="1">MEYLGIFILAIVWDLTLGEPPVLLHPTVWFGRLIGFFDKHYKRRSPALDFVAGTFASLFVIAVAFALSRLPGFLPKWLCFALSVYLLKSSFAIKSLAQHVRNTIREDIEEQRKYVSWIVSREVSKLDRAHLNSAAIESLAENITDSVVAPLFYYLIFGLSGALIYRAVNTLDAMIGYKNERYLYFGKFAARLDDLLNFIPARITVLLFLPFNPGKVIQYWRKARFKLNSDKPIAAMSAILGVWLEKKGVYRFEGKEPRLEDIGKALRVYWAVVEEWIAFVFVSEIVKSFFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK00</accession>
    <name>F0LK00_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenosylcobinamide amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466835.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00560"/>
    <dbReference type="EnsemblBacteria" id="ADT83537">
        <property type="protein sequence ID" value="ADT83537"/>
        <property type="gene ID" value="TERMP_00560"/>
    </dbReference>
    <dbReference type="GeneID" id="10040878"/>
    <dbReference type="KEGG" id="tba:TERMP_00560"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.561"/>
    <dbReference type="eggNOG" id="arCOG01870">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1393641_0_0_2"/>
    <dbReference type="OMA" id="SNAPHRG"/>
    <dbReference type="OrthoDB" id="72101at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002808">
        <property type="entry name" value="AdoCbi_amidolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01955">
        <property type="entry name" value="CbiZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="195" mass="21236" checksum="08DDB411DF6DC9EF" modified="2011-05-03" version="1">MVNKHYIHPFKEPMLSLSNAPHNGGLFKANGFFFMHVHKNYSGNYKEDCLNFEKQNGLRDFVGFMTAVDIPKVLAHAKSGRVEAYVTAGITNPAIAGDEPPPWKPGTINIAIIIHKGLTVGALANAIMTATEAKTYTLLKLGYNATGTTSDGIGVFAYEGREEWAGTATKLGISIGKAIRKALKESLVKWEKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK38</accession>
    <name>F0LK38_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468047.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01775"/>
    <dbReference type="EnsemblBacteria" id="ADT84750">
        <property type="protein sequence ID" value="ADT84750"/>
        <property type="gene ID" value="TERMP_01775"/>
    </dbReference>
    <dbReference type="GeneID" id="26137288"/>
    <dbReference type="KEGG" id="tba:TERMP_01775"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1774"/>
    <dbReference type="eggNOG" id="arCOG02640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104916_0_0_2"/>
    <dbReference type="OMA" id="WVGDLAD"/>
    <dbReference type="OrthoDB" id="63024at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002727">
        <property type="entry name" value="DUF47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36536">
        <property type="entry name" value="PTHR36536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00153">
        <property type="entry name" value="TIGR00153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="224" mass="26012" checksum="BBC017E640488C21" modified="2011-05-03" version="1">MQVWTKLFAKSPFKPLIKHAEVVLETVETLERALELWHEGKYQEMEKVAIEVDNLEDIADRIKEEIRDSLTTKLFMPVNRNDILEYLHMQDKIADAAEDTAKWLLIKRPKEIPEEIKGIILKMGKESIKAAKLVHNAILQMDTVIESGFSEKEIEREYELIKEIESVENKIDGLDTKLMKLVFENEDKLSWGDGIYILNIARTLSNISDKAKDSAERIRLMMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK76</accession>
    <name>F0LK76_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468084.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01813"/>
    <dbReference type="EnsemblBacteria" id="ADT84788">
        <property type="protein sequence ID" value="ADT84788"/>
        <property type="gene ID" value="TERMP_01813"/>
    </dbReference>
    <dbReference type="GeneID" id="26137329"/>
    <dbReference type="KEGG" id="tba:TERMP_01813"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1812"/>
    <dbReference type="HOGENOM" id="CLU_2893445_0_0_2"/>
    <dbReference type="OrthoDB" id="130926at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="62" mass="7627" checksum="463B4333FCD7D15E" modified="2011-05-03" version="1">MKVIKVEVPEWVDEEEVKRIIKIFFTEKPDFMDFAGLWKDMSEEEAKEFKATIKRMWDTWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKA8</accession>
    <name>F0LKA8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466864.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00589"/>
    <dbReference type="EnsemblBacteria" id="ADT83566">
        <property type="protein sequence ID" value="ADT83566"/>
        <property type="gene ID" value="TERMP_00589"/>
    </dbReference>
    <dbReference type="GeneID" id="10040907"/>
    <dbReference type="KEGG" id="tba:TERMP_00589"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.590"/>
    <dbReference type="eggNOG" id="arCOG09830">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2613810_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="78" mass="7848" checksum="1169ADC526D232F6" modified="2011-05-03" version="1">MWRKALVIGLVLIAMGMVVGGAVGHESFVVWKITHSEKMGAVTIGGGLAMGTALIKAGIVATLGAATGWFLGVVIVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKI9</accession>
    <name>F0LKI9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA/RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468119.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01848"/>
    <dbReference type="EnsemblBacteria" id="ADT84823">
        <property type="protein sequence ID" value="ADT84823"/>
        <property type="gene ID" value="TERMP_01848"/>
    </dbReference>
    <dbReference type="GeneID" id="10042164"/>
    <dbReference type="KEGG" id="tba:TERMP_01848"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1847"/>
    <dbReference type="eggNOG" id="arCOG00871">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013713_0_0_2"/>
    <dbReference type="OMA" id="INYEAPW"/>
    <dbReference type="OrthoDB" id="47433at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024975">
        <property type="entry name" value="NOV_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13020">
        <property type="entry name" value="DUF3883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="50"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="391"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="952" mass="110329" checksum="9357A833FDF9E9EF" modified="2011-05-03" version="1">MIRGFESEFKVYLANRIIRSNPIAFFFAITNPLSKQKIIPFLHQADLLLHLMTVRPIRVLIADEIGLGKTIEALAIAKYLELQDGIRKVLILTPKILIEQWVSEVKRVGGMPWIVSSGSQLKNTFFKSGVDKAYYYIMSIDLAKRYPDIIDSVGWDLIIVDEAHNATLGTQRDYLLRRLTSNKHRNIILLSATPHRGDYKDYLNRLRYLDPTLTENYDALDAPKFYRVTHETLVFRRTKGIVNQAEGEEIFKKCHVHSFIVDISDVEKEYFSELQKILTEMIAPDNIPLSLLAVILRKRASSSYYASIQTLNRMISKSRGKEHPKKVEDILQKIFALGYDELEIEADEIDEELNKIVEAYADILTSRQIEKLRGILELARKAQEKDSKIKNVAKLVKYHLDRGEKIVIFTEYLDTLEYLKNNLPKYLGINETDIVTISGKNKGDVHNIKERFEQENGAKILIATDVAGEGLNLQVANVLINYEAPWSPIKLEQRMGRIWRLGQKKESYVYTVFLSNKMDRDVLENLYHKLMNIDKAMTNPPQLVGSKVYIASAENLWRADLGLLNLDPKKRKKINEYTLVLESIKGNLGIYVRELLAMINQLSARLRAKSVFPVIKGEKIRSELSKYLGSDYLSRKQVEKELQEWLSLFIYGGDKKAINLWKELNALLLKGSTDLGSKMILFVKGEETLRRIYLVKLKNSSQTLIEIPVAIDKKGDILYGLKLLEALKDMSTQILTAVPYESVEETNQTSIEKFRDIGKIKSTIRKLLQEISFKWEKYEDRFHKPLKAGQVFFPLDFDKTTVEEIAIFKYIREVESGEEKWERNSPTEEILKIEKEAMRIAIEYEKQRYIRKYGNDPSKWLVKNVSLEEHYDILSRDLVTGEVRYIEVKGHKGFSLWAELTEAEHKFAEDHAPNYWLYLVVNIGKEPMLFRFRNPLETLDIKTKKRYVLYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKJ8</accession>
    <name>F0LKJ8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468128.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01857"/>
    <dbReference type="EnsemblBacteria" id="ADT84832">
        <property type="protein sequence ID" value="ADT84832"/>
        <property type="gene ID" value="TERMP_01857"/>
    </dbReference>
    <dbReference type="GeneID" id="10042173"/>
    <dbReference type="KEGG" id="tba:TERMP_01857"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1856"/>
    <dbReference type="HOGENOM" id="CLU_2285183_0_0_2"/>
    <dbReference type="OrthoDB" id="137033at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="101" mass="11106" checksum="D93C2CA4408AE63C" modified="2011-05-03" version="1">MDPEKLFALFVSTMIALIVAVTIPSQEKVAYDALTPAINEIYEQAQSQINDSQLESSMGLAKLSWNLLGFGIWLLEVLAPFAIILSFLAKAGLFDGFDFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKP7</accession>
    <name>F0LKP7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468177.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01906"/>
    <dbReference type="EnsemblBacteria" id="ADT84881">
        <property type="protein sequence ID" value="ADT84881"/>
        <property type="gene ID" value="TERMP_01906"/>
    </dbReference>
    <dbReference type="GeneID" id="26137442"/>
    <dbReference type="KEGG" id="tba:TERMP_01906"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1905"/>
    <dbReference type="eggNOG" id="arCOG05833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147803_0_0_2"/>
    <dbReference type="OMA" id="LEGWEPK"/>
    <dbReference type="OrthoDB" id="125133at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="144" mass="16477" checksum="F48C089C23962F17" modified="2011-05-03" version="1">MRVSKALFLAVPFALMAFLSGSYLVRWLGVIIAGVILIVVLFGFEIQSEYIPRRKRNLISGKSDLERLTSVVKRAKKGKMAREIIAEEIREIYALLSDEYTRFDLKSNPNEALRLLHSEGDFYENLKKALEIVEADLNEDRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKS0</accession>
    <name>F0LKS0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466947.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00672"/>
    <dbReference type="EnsemblBacteria" id="ADT83649">
        <property type="protein sequence ID" value="ADT83649"/>
        <property type="gene ID" value="TERMP_00672"/>
    </dbReference>
    <dbReference type="GeneID" id="10040990"/>
    <dbReference type="KEGG" id="tba:TERMP_00672"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.673"/>
    <dbReference type="eggNOG" id="arCOG01006">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1006926_0_0_2"/>
    <dbReference type="OMA" id="RIDLMAY"/>
    <dbReference type="OrthoDB" id="68244at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="273" mass="29376" checksum="3FE5CB365E62BCD0" modified="2011-05-03" version="1">MIPEYLLRALFASMMISVLLGMLSPLINMKGLAFLTHATFHSLLFGAVLGMILGLLVGNLGIIVWVALVVTVVVVIIIAEIENRGFTSDTAIGIISSFVAGATVLGFGILYKVTASKPYFALSESIVAYLTGEVFLITISDLEMLIFGGFLLFLLMFLLYRDFLYVSFDPEGVESYGGNVRAYLMILYIIVGAIGALIVKTVGLITLQVVAVLPGAIAMMLSDDLRKIVGISLFLTLSIEILSIFLAYATNIPPSGIATILLGVIYGTLVFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKV4</accession>
    <name>F0LKV4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00706"/>
    <dbReference type="EnsemblBacteria" id="ADT83683">
        <property type="protein sequence ID" value="ADT83683"/>
        <property type="gene ID" value="TERMP_00706"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00706"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.707"/>
    <dbReference type="eggNOG" id="arCOG05815">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1127138_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="262" mass="28974" checksum="63E503E37B07E25B" modified="2011-05-03" version="1">MENAINMLTKNPALVLVPILIAFILAPINTSNNNTNFHFPQESAEVAKEQLRNFVHDFVKDAVIFGILTSIMQAISGYSVSSGVLDIIRQKDYRIAQTIVEALKNLPQVAFLNVFGWVVTILVIAPPFAYLYSEIMKAESFTIPGSVMDNFFFLAIVSLLILLYVAPASLLLIPAYVKTKSIRSALKVYRLALNRLSSTIGFGILVFIAIAIINLPTMLTRFINNQLLAGIVTAPFNGLSNAFSMAAATLFYLFLIEEMEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKY0</accession>
    <name>F0LKY0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468183.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01912"/>
    <dbReference type="EnsemblBacteria" id="ADT84887">
        <property type="protein sequence ID" value="ADT84887"/>
        <property type="gene ID" value="TERMP_01912"/>
    </dbReference>
    <dbReference type="GeneID" id="10042228"/>
    <dbReference type="KEGG" id="tba:TERMP_01912"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1911"/>
    <dbReference type="eggNOG" id="arCOG03834">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139906_0_1_2"/>
    <dbReference type="OMA" id="EWEMGLQ"/>
    <dbReference type="OrthoDB" id="99229at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016645">
        <property type="entry name" value="UCP016134"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016134">
        <property type="entry name" value="UCP016134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="5"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="116" mass="13661" checksum="ADC0D11C3D6987F5" modified="2011-05-03" version="1">MKWEMGLQEEYLKLIAEGKKKIEGRLYDEKRRQIKPGDIIIFEGKLKVKVKDIRVYPSFKEMLEKEGLENVLPGIKSIEEGVKIYRQFYSEEEEKKWGVVAIEIEPIRDTSPSNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKY1</accession>
    <name>F0LKY1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468184.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01913"/>
    <dbReference type="EnsemblBacteria" id="ADT84888">
        <property type="protein sequence ID" value="ADT84888"/>
        <property type="gene ID" value="TERMP_01913"/>
    </dbReference>
    <dbReference type="GeneID" id="10042229"/>
    <dbReference type="KEGG" id="tba:TERMP_01913"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1912"/>
    <dbReference type="eggNOG" id="arCOG00683">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040997_0_0_2"/>
    <dbReference type="OMA" id="CGHVSKS"/>
    <dbReference type="OrthoDB" id="13813at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="191"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="318"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="435" mass="50272" checksum="272F00F41036E1DD" modified="2011-05-03" version="1">MKRTVIVKLQPSKEQTKILSELADLGAKAWNRVNYLRRQQFFEGKIVDFNGTEKTVYEEFKKKIGSATVQQICRKNAESWRSFFSLLRKKRNGELPSWLKPKPPNYLKEDGRRKPLIVLRNDQYRIEGNRLILKGLGKFKRLEIQFKGRIHLKGKQGRLEITYDWVKRKWYAHLSLTVEEKLEGKEWVKVPREPLGNLSAGIDLGVNNLMAVYAENGESFLMNGRPLKSIDFYWRKRIAEYQSKLNKSGAKKSRKLKRMHEKAKLQAKHYINTAVRQTVKKLYDLGVSKIVVGYPKEIARNSERGKKQNFILSHIWRFNTVIKRLTEVSEEYGIRVILVNEAFTSQLCPLCGKPHEGARFVRGLFKCPTEGLVFNADLVGAFNILRKVKTITPNLGGLLAQERGNWPKTRPGGSKARFELGWNETPQTSLPMARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL02</accession>
    <name>F0LL02_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01934"/>
    <dbReference type="EnsemblBacteria" id="ADT84909">
        <property type="protein sequence ID" value="ADT84909"/>
        <property type="gene ID" value="TERMP_01934"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01934"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1933"/>
    <dbReference type="eggNOG" id="arCOG01403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_5_2"/>
    <dbReference type="OMA" id="IRIVPGC"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="32"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="191"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="381" mass="43879" checksum="27E5631362509642" modified="2011-05-03" version="1">MTLKVTLMLPYTEKPYGGARAVAYNTVEGFRKIAKLLEKNDVHLTIVSTARDAVISKKDMHPNIEILHYKFPSFATFSGAFHSYKKNKYFFLSSDLVHAHDIYNAFASSQTRTKTIMTLHGLYWRDLKADRFSVQRLFYYGWNTLQFATIFHKLTKFVAISRYVQRELKVLGIYDESKIIVIENPVRDELFDVEHVETGNLILYPAKIYPLKNQLTFIKALGILKNQTREDFKVIFAGKVVDAPYYSQILSGIKKLNLQNYIKFELYSYEKMPDVYAQCSITALTSYHENAPMSISESFAVGVPVIASNVGGIPYMVSHGKDGFIVQPNNPEDIAEKLLILLEDRKLRKRMGKEAKKKAQERWRDRVIAENLLNLYLQLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL35</accession>
    <name>F0LL35_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-glucosides-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468238.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01968"/>
    <dbReference type="EnsemblBacteria" id="ADT84942">
        <property type="protein sequence ID" value="ADT84942"/>
        <property type="gene ID" value="TERMP_01968"/>
    </dbReference>
    <dbReference type="GeneID" id="10042283"/>
    <dbReference type="KEGG" id="tba:TERMP_01968"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1966"/>
    <dbReference type="eggNOG" id="arCOG00149">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654913_0_0_2"/>
    <dbReference type="OMA" id="KPGFWYR"/>
    <dbReference type="OrthoDB" id="33798at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="427" mass="47982" checksum="6EFADDC5C966E6C2" modified="2011-05-03" version="1">MPQRKMLGILLLGIFVFSVVASGCISQTSQSPTATTITKTETKVQTETKVQEQITLKVIGPWSGKELDAFMKVIEAFEAQHPNIKIEYKTYRAEDLATILPLQFESGDTPADVIFMWGWFIKKMGEKGHLMTFNDVINPDEYIPGVLDAVMSNGKIYGAPFTAAAKPGFWYRKSFFKKYGLKPPQTWDEFVSLLAKIKEIPGIKAPIVSGDSVGWPLSDVTEHFILTFGGADLQLKLIKGDVKFEDPQVRDIFANKLVPLLKAGYFSEPVEWTSAVTAWWKGDYALYFMGTWITGMVDDPNDLGMFSLPGCKAMVLAPDYLMVPKYTAHPKEAMELAKFLATEGQRVHVGTNSGKLATWKKVTLDDYWPPMRDVAKIVSNVQAVPDLDDSVGGEWQKTFWDQLKLLWVQPDRLDDVLKTLDEKFPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL60</accession>
    <name>F0LL60_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467009.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00734"/>
    <dbReference type="EnsemblBacteria" id="ADT83711">
        <property type="protein sequence ID" value="ADT83711"/>
        <property type="gene ID" value="TERMP_00734"/>
    </dbReference>
    <dbReference type="GeneID" id="10041052"/>
    <dbReference type="KEGG" id="tba:TERMP_00734"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.736"/>
    <dbReference type="eggNOG" id="arCOG05807">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688155_0_0_2"/>
    <dbReference type="OMA" id="MHHYREV"/>
    <dbReference type="OrthoDB" id="57559at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="396" mass="46263" checksum="AA702DF243F6A925" modified="2011-05-03" version="1">MRIAWALMVLLLGSLVPLSVAQEEASNTTEIQQLSLDNATREQIIAEQLINQLMRLDKFTEKRIEPIRDKLPENSTILIHYEKAKEYKEKALEEFNNGSYYNSILDALTAMHHYKIVLRELKEGKEKVEDAREWIRAEIERTIRYFKFVEKTIRMAEKEGIDVSNLTVLYNETKQAYKVVLEDIKAKDFGKAREDLQVAKEKKMQLDKELRRVRKELAYANADRIVKGFLTRTSRGIAFAERAIQEAKIRGIDTAEAEDKLEEIKAIYDEVKSLAEQEKWEDALTVIINNKAEIDAFFRSLNRIHEKFAEEKIKRDAGAFLREMQDRIRKDTRALQELKRRGVDTRRAEIELRTAAQELQIGLRLLKERKPALAREHFGIALRLLYSVEQFILSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL61</accession>
    <name>F0LL61_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TrmB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467010.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00735"/>
    <dbReference type="EnsemblBacteria" id="ADT83712">
        <property type="protein sequence ID" value="ADT83712"/>
        <property type="gene ID" value="TERMP_00735"/>
    </dbReference>
    <dbReference type="GeneID" id="10041053"/>
    <dbReference type="KEGG" id="tba:TERMP_00735"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.737"/>
    <dbReference type="eggNOG" id="arCOG00374">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079811_0_0_2"/>
    <dbReference type="OMA" id="YKVGREN"/>
    <dbReference type="OrthoDB" id="123314at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="209"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="276" mass="31016" checksum="FB79A819843AB082" modified="2011-05-03" version="1">MKKSITLISLALLIIPLVSAEFTVSELELTIYRDGYVEVSYQIIPSDYAVQISVPLLGENYENLIVEDENGNPLNFEISGNSVVIYVDDAQLIKLSYYTPDLTSKHGLVWTLNVSSPYPFKVVLPQNAIVVDLSDIPLSISANVISMPPGNQSISYTLGYGVEKASQNWVYYLITSVLIISAVFIGIKLISKRSSKSIKIDREAFLKKMEKFDLNDEEKSALLYILEKGGRASQAEVRNALGLPKTTAWRMFKRLEKQGLVKIIRGRKENWVELKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL95</accession>
    <name>F0LL95_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate kinase</fullName>
            <ecNumber evidence="3 11">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">TERMP_00769</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 11"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467044.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00769"/>
    <dbReference type="EnsemblBacteria" id="ADT83746">
        <property type="protein sequence ID" value="ADT83746"/>
        <property type="gene ID" value="TERMP_00769"/>
    </dbReference>
    <dbReference type="GeneID" id="10041087"/>
    <dbReference type="KEGG" id="tba:TERMP_00769"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.771"/>
    <dbReference type="eggNOG" id="arCOG04120">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_2_2"/>
    <dbReference type="OMA" id="QVPIVQK"/>
    <dbReference type="OrthoDB" id="40634at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="12">
        <location>
            <begin position="6"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="13">
        <location>
            <begin position="363"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADT83746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="475" mass="52481" checksum="82D65CC0596D3109" modified="2011-05-03" version="1">MRLPSHKTKIIATIGPASNSKNMIERLIKAGMNVARINFAHGNFEQHAETIETIREVSERLNTRVAILGDLPGLKIRVGKLKGDAVVLHRGQTVVLTNRGIEGDETTIPVECEAFPKLVSKGDVIYLSDGYITLKVEDVQGNDVICRVIVGGTLFSRKGINIPKINLPLEAITERDLEILEFALEHGVDAVGISFVGSAYDVMKVKRFAEKRGKQIFTIAKIERPDAVRNFDEILNAADGIMIARGDLGVEMPIEKLPIIQKKLINKANLVGKPVITATQMLVSMTADKIPTRAEVTDVANAILDGTDAVMLSEETAIGKYPVEAVRMMARIAKTTEAYRESSGHTRMLEWKEKIPKRGTIKDAITRSIIEALNTVDIKYILTPTRTGQTARLISRFKPKQWILAFAEDEQVCNSLMFSYGVYPFCVEDTTNEQELIQLIKDLGIVKTNDTVLLTSGKPIEKTVGTNTIKIFTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLA5</accession>
    <name>F0LLA5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467054.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00779"/>
    <dbReference type="EnsemblBacteria" id="ADT83756">
        <property type="protein sequence ID" value="ADT83756"/>
        <property type="gene ID" value="TERMP_00779"/>
    </dbReference>
    <dbReference type="GeneID" id="26136234"/>
    <dbReference type="KEGG" id="tba:TERMP_00779"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.781"/>
    <dbReference type="eggNOG" id="arCOG01679">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_9_1_2"/>
    <dbReference type="OMA" id="WYVYELA"/>
    <dbReference type="OrthoDB" id="111804at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="98" mass="11561" checksum="6859BCB430B698BB" modified="2011-05-03" version="1">MVGSIQELTVVAEALSVPIRVKILKMLCEKEWYVYELAKELNISRQLLYLHLKKLEKANLVESELRLEPGDPRAKKYYRAKPFRFVIDNDIIKNLKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLE2</accession>
    <name>F0LLE2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01997"/>
    <dbReference type="EnsemblBacteria" id="ADT84971">
        <property type="protein sequence ID" value="ADT84971"/>
        <property type="gene ID" value="TERMP_01997"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01997"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1994"/>
    <dbReference type="eggNOG" id="arCOG05741">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2021590_0_0_2"/>
    <dbReference type="OMA" id="KVDKMDY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="120" mass="13831" checksum="51D5CD4AF3EF882A" modified="2011-05-03" version="1">MEVQIRRRKPGVERKIGEISEDDTRVALIGKVVKVDKLDYLFWLDDGTGVAVIETEENVLPKVGQIVRVIGRIIRNEEMHIYAEVVQDFSDADLESLEEIQELEKKVLPKIENALAWWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLF6</accession>
    <name>F0LLF6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ordered locus">TERMP_02011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468281.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02011"/>
    <dbReference type="EnsemblBacteria" id="ADT84985">
        <property type="protein sequence ID" value="ADT84985"/>
        <property type="gene ID" value="TERMP_02011"/>
    </dbReference>
    <dbReference type="GeneID" id="10042326"/>
    <dbReference type="KEGG" id="tba:TERMP_02011"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2008"/>
    <dbReference type="eggNOG" id="arCOG01711">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073198_1_2_2"/>
    <dbReference type="OMA" id="DEPTFPG"/>
    <dbReference type="OrthoDB" id="103587at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="178" mass="20829" checksum="75CC126F3910ADCA" modified="2011-05-03" version="1">MNPFHDLEPGPEVPEVVYALIEIPKGSRNKYELDKKTGLIKLDRVLYSPFHYPVDYGIIPQTWYDDDDPFDIMVIMREPTYPGVLIEARPIGLFKMIDSGDKDYKVLAVPVEDPYFNDWKDIDDVPKAFLDEIAHFFRRYKELQGKEIIVEGWENAEKAKQEILRAIEIYKEKFGKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLL6</accession>
    <name>F0LLL6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Archaeal heat shock regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT83793">
        <property type="protein sequence ID" value="ADT83793"/>
        <property type="gene ID" value="TERMP_00816"/>
    </dbReference>
    <dbReference type="GeneID" id="26136268"/>
    <dbReference type="KEGG" id="tba:TERMP_00816"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.818"/>
    <dbReference type="eggNOG" id="arCOG01684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090889_1_0_2"/>
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    <dbReference type="OrthoDB" id="87825at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
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    </dbReference>
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        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="204" mass="24179" checksum="3C6B9A76D475579F" modified="2011-05-03" version="1">MLNNEMGKLLDVLGNETRRRILLLLTKRPYFVSELSQELGVGQKAVLEHLRILERAGLIEGRVEKIPRGRPRKYYTIKRGFRLEVLLTPYIFGTEMYEPKAPRRTAEYEQAKELIKSQEPVETKIKELAEFLKDIEEKIAEHMRAKQELEEVRLLAEAYIENLMRRIAQESESEFEEILKELEEYLPTELMAELKRIKKELYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLP7</accession>
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            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
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    </gene>
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        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83824.1"/>
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    <dbReference type="EnsemblBacteria" id="ADT83824">
        <property type="protein sequence ID" value="ADT83824"/>
        <property type="gene ID" value="TERMP_00847"/>
    </dbReference>
    <dbReference type="GeneID" id="10041165"/>
    <dbReference type="KEGG" id="tba:TERMP_00847"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.850"/>
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    <dbReference type="OMA" id="ITPVDVF"/>
    <dbReference type="OrthoDB" id="105481at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
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    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="103" mass="11343" checksum="DDB05AD23599DA94" modified="2011-05-03" version="1">MIVVKVGEAERIDNPHGVDVKKLIGMENVQILHVTLKPGEGLKKHATPVDAFLYVIKGKGMVEVGDEKEEVRKATLVYLPKEVPHSVENTGSLEMKFLVIKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLQ5</accession>
    <name>F0LLQ5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase chain C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="391623.TERMP_00855"/>
    <dbReference type="EnsemblBacteria" id="ADT83832">
        <property type="protein sequence ID" value="ADT83832"/>
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    </dbReference>
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    <dbReference type="KEGG" id="tba:TERMP_00855"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.858"/>
    <dbReference type="eggNOG" id="arCOG01551">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_6_1_2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="1">
        <location>
            <begin position="32"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="173" mass="20895" checksum="537F8D15E6BCCC61" modified="2011-05-03" version="1">MTMKEQEIVEMILKKAPYAEGKVRRERRIEFKVPADRIRDFLTLMKESGFELMLQITPVDWIKEGEIELIYQIWSVTHKIHAMVKTRIPRELEKARMPTVKDIYPAAETYERDAHEFFGVYFEGNEKMEMPWILDDTERGTYPLRKDFDMLSYVKKKYKILDRFDENKDNYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLQ7</accession>
    <name>F0LLQ7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase chain H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467132.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00857"/>
    <dbReference type="EnsemblBacteria" id="ADT83834">
        <property type="protein sequence ID" value="ADT83834"/>
        <property type="gene ID" value="TERMP_00857"/>
    </dbReference>
    <dbReference type="GeneID" id="26136306"/>
    <dbReference type="KEGG" id="tba:TERMP_00857"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.860"/>
    <dbReference type="eggNOG" id="arCOG01545">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_2_2"/>
    <dbReference type="OMA" id="WSGWASN"/>
    <dbReference type="OrthoDB" id="88886at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="309" mass="33615" checksum="ADAFB9913DD82F37" modified="2011-05-03" version="1">MLETVLKAFLILLYATFVGFMFMGIIRIVTARIHRRVGPPIYQPILDTIKLLSKKSNITHGLIYDFGIIYALGATILALMFIPLGSISILRAYGDLILITFLLEIPMLGIMFAAMSSGNPWAGLGAQRALLTLLAIQVPLGFAIVALAEFYGTFSTYQIVMAQQSMGWSITHLPLLLAAIAYDIVLQAMFGKEPFDIMIAPGEISLGPMVEFGGKHMGILQIQHAIALFAETLFFSNIFLGGAVITAFASPILNTIASLAVLLIKQIAVLMIAIFIGAIFPRFTIDQAARFYWKWPTIIAATGAILAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLR0</accession>
    <name>F0LLR0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
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        <property type="protein sequence ID" value="ADT83837.1"/>
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    <dbReference type="PATRIC" id="fig|391623.17.peg.863"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="114" mass="12163" checksum="2FF96B01BBF357D7" modified="2011-05-03" version="1">MISAYYFGAISLILIGLYAVLTKRNLLKILVGLSIMETGVNLLLISVGYVSGRTAPILTEGATPQTTVDPIPQALVLTAIVIGVATMALALTVAINLYEKYKTLDIEKIRGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLR4</accession>
    <name>F0LLR4_THEBM</name>
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        <submittedName>
            <fullName evidence="8">Putative Na(+) H(+) antiporter subunit F</fullName>
        </submittedName>
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        <name evidence="8" type="ordered locus">TERMP_00864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
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            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
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            <topology evidence="2">Multi-pass membrane protein</topology>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="26136313"/>
    <dbReference type="KEGG" id="tba:TERMP_00864"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
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        <property type="entry name" value="PTHR34702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="84" mass="9328" checksum="231C1F9947489440" modified="2011-05-03" version="1">MIGINVYLAVIVVATLLSMYRFFRGPTTVDRLVAVDIMTTITTGLMVLFALYYRRAIFLDVALVYAVLAFLGVIAFARYLEGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT85076">
        <property type="protein sequence ID" value="ADT85076"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134210_2_0_2"/>
    <dbReference type="OMA" id="DYKEPCE"/>
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    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="169" mass="19267" checksum="20CF1C35A2C775FC" modified="2011-05-03" version="1">MTSLFLDSNVIIEFAKDNPRAVELLEHIFKHSFTAFVNGIVYSEVFFIFIKAKTGKSYWELKKNKSLVKETAEEFLKSLFPMLSIPNFLEVTSEIILLSIEVSRKYGLLPNDALILATCKFYGIKYLVSLDDDFKEACKKEGIVLIDSVEKLKEELTERGIPAKGDKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLZ1</accession>
    <name>F0LLZ1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02116"/>
    <dbReference type="EnsemblBacteria" id="ADT85090">
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    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02116"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2113"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097795_0_0_2"/>
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    <dbReference type="OrthoDB" id="82530at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="261" mass="29058" checksum="7C4357EE82C72AD7" modified="2011-05-03" version="1">MVIEGKGKNMKVERLAGIALIITGGSLLIYGAVNANQSLINLGLAGIFLGVVILTFKSHEYVKREALDSLTLPYVKALQKIVNDLGLEGKALYIPPYENLKEGGVFIPLHEEFDLDLGRLDDETVFLTNVSSERQMGLSIRPLGLDLLRKYEEHLEYSLENSNYKEVESVSSSVLRALDLANTVYIEEENNSFRIIVSPTNKEICRKNIEHCDQVACPICSSILLGLAKASNEVVMSEKFSFVKHGIEIKARKLGGIREWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLZ9</accession>
    <name>F0LLZ9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468394.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02124"/>
    <dbReference type="EnsemblBacteria" id="ADT85098">
        <property type="protein sequence ID" value="ADT85098"/>
        <property type="gene ID" value="TERMP_02124"/>
    </dbReference>
    <dbReference type="GeneID" id="10042439"/>
    <dbReference type="KEGG" id="tba:TERMP_02124"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2121"/>
    <dbReference type="eggNOG" id="arCOG01403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_1_2"/>
    <dbReference type="OMA" id="DLIIAHT"/>
    <dbReference type="OrthoDB" id="83551at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="188"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="348" mass="40247" checksum="21F7BFA36D09DB19" modified="2011-05-03" version="1">MKILIVSPYFHPEGGGLERYAYQMARKLSRSNDVTVVCMTKKESKTERVGKIKVYRLKPLFILSNTPVSLIFVIKLAQMIKKGEFDLIIAHTPVPFAADVASLLAKIFGIKIKIVYHTVGLKKGNTVLDIVGRVYSYTLEKLTLRNCEIISVSEKVWEYLKSRGYNSRIIIPEISEDLRDIKLDRNIKRENAILFVGQLSRYHRFKNLDMLIEVFARVSKEFPDWKLWIVGDGDLREYYEDLVRKLNLKDKVKFFGNVENPEDLAEIYSRAKILVLPSSFESFGMVVLEALHFRISVVVNKNVGAVDRLILPRKNGFIFDTRSELLIILTKLLDNPKIVRKMMFRKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM22</accession>
    <name>F0LM22_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0107 protein TERMP_00892</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0107 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467167.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00892"/>
    <dbReference type="EnsemblBacteria" id="ADT83869">
        <property type="protein sequence ID" value="ADT83869"/>
        <property type="gene ID" value="TERMP_00892"/>
    </dbReference>
    <dbReference type="GeneID" id="26136337"/>
    <dbReference type="KEGG" id="tba:TERMP_00892"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.894"/>
    <dbReference type="eggNOG" id="arCOG04279">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141583_2_0_2"/>
    <dbReference type="OMA" id="CEPIVAT"/>
    <dbReference type="OrthoDB" id="108624at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01356">
        <property type="entry name" value="AcnX_swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00078">
        <property type="entry name" value="UPF0107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020794">
        <property type="entry name" value="AcnX_sub2_archaea_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012016">
        <property type="entry name" value="AcnX_sub2_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002840">
        <property type="entry name" value="AcnX_swivel_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01989">
        <property type="entry name" value="DUF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004966">
        <property type="entry name" value="UCP004966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF126" evidence="3">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="134" mass="14589" checksum="535FDCB583035C0E" modified="2011-05-03" version="1">MKLKGRRITKGKAKGIALVSRRPLSFLGGIDPKTGIITDVESDIRGESVKDKILVFPRGKGSTVGSYIIYQLKKNNVAPKAIVVEDAETIVATGAIIAEIPMVDRIDIRKIKNGQIIEVDADRGEIIIHEEEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM58</accession>
    <name>F0LM58_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00929"/>
    <dbReference type="EnsemblBacteria" id="ADT83905">
        <property type="protein sequence ID" value="ADT83905"/>
        <property type="gene ID" value="TERMP_00929"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00929"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.930"/>
    <dbReference type="eggNOG" id="arCOG03799">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076516_0_0_2"/>
    <dbReference type="OMA" id="INESAWA"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008553">
        <property type="entry name" value="DUF835"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05763">
        <property type="entry name" value="DUF835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF835" evidence="2">
        <location>
            <begin position="123"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="304" mass="34676" checksum="417EFD534AD6958B" modified="2011-05-03" version="1">MESVTLSLIFGSVLLIIGIYGTVIAWRFYILLDSPADKFALQVMVAFILFGVLGGGAVVGSAFFEGTWWPFIALFTMSGFLILAFSSLHYLRLLYEEFGSKINSREERKHIPVGGFIIESLEGIKTLLKYLSSKSGGLFVISRRPRDEWEEEFGIKPTKYLWLSRVEEKHSVSPSNLHVILEEAVRFMRIRKNSVIYIEGIEYLVLYNDFKSVAKFLFTLKDYATVEKSVLLIFISPGVLEKSHYNILRRELEVLNPEKFLEEIMGTALFGAVAKEEFEKITTEKPLNEKEDREEHASSESSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM61</accession>
    <name>F0LM61_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable ribonuclease FAU-1</fullName>
            <ecNumber evidence="6">3.1.26.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA-binding protein FAU-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fau-1</name>
        <name evidence="8" type="ordered locus">TERMP_00932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FAU-1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.-" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467206.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00932"/>
    <dbReference type="EnsemblBacteria" id="ADT83908">
        <property type="protein sequence ID" value="ADT83908"/>
        <property type="gene ID" value="TERMP_00932"/>
    </dbReference>
    <dbReference type="GeneID" id="10041249"/>
    <dbReference type="KEGG" id="tba:TERMP_00932"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.933"/>
    <dbReference type="eggNOG" id="arCOG04307">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044303_0_0_2"/>
    <dbReference type="OMA" id="GTYVNVC"/>
    <dbReference type="OrthoDB" id="83570at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:endoribonuclease activity, producing 5'-phosphomonoesters"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01910">
        <property type="entry name" value="RNA_binding_AU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016730">
        <property type="entry name" value="RNA-bd_FAU-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018644">
        <property type="entry name" value="RNA-binding_FAU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DUF402" evidence="7">
        <location>
            <begin position="377"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="471" mass="54298" checksum="57B733828E70B62B" modified="2011-05-03" version="1">MSTNSGVSVRIRGIYSTALTKLLLDKGFKISQPSQKIAERLKIEKTYSEFDVDIYDRKDGRGVILVGTKVDDVKDVFEEEFIDVFFRKMPYQLYGIYKGIVVKRDEQYLYVDIGSAIGTVLIEEMPDAVEGDEVLVQVKKHNLLPHLSTLLTIPGDYAVLIPKPIGAQRHVKISRKIRDPEERERLRILGLSVDLGEWGILWRTAAAYKDWNTLRDELVNLSKIADKLKDADKYSAPARIIEGRDIYEVEFGGGTRKKLDNIRNEVLPTIEGHHQFKAYDPEFSFAVEIAEGILSKMPSQRLKVREGFMEALIDNKGPKIGWLFTLEHIKPDGQKVRIGPGEILEVSINPLRIKIKRSLKPGKVYDGLELPIEYGDYAITEIEEGKWWYKHSYYDKDGNLKGEYYNINTPIEIYPDRARYIDLEVDIVKWPDGKKEIIDKDDLRRHYEEGIISEKLYKATLRITQEVFEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM92</accession>
    <name>F0LM92_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467237.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00963"/>
    <dbReference type="EnsemblBacteria" id="ADT83939">
        <property type="protein sequence ID" value="ADT83939"/>
        <property type="gene ID" value="TERMP_00963"/>
    </dbReference>
    <dbReference type="GeneID" id="10041280"/>
    <dbReference type="KEGG" id="tba:TERMP_00963"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.966"/>
    <dbReference type="eggNOG" id="arCOG03602">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046840_2_0_2"/>
    <dbReference type="OMA" id="AKAQGWW"/>
    <dbReference type="OrthoDB" id="5084at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="427" mass="50317" checksum="99A647337E106CF6" modified="2011-05-03" version="1">MCDILVATPDATKEEIMIFAKNSDRDPNEAQILEFLPRQKHEEEKVKLTYVEFPQVKETYAVILSRPWWMWGAEMGANEFGLVIGNTAVFTKLKVPERGILGMDMIRLALERTKSSREALDFIISLIEKYGQGGNGSYEHKLLYHNSFIIADKNEAWVVETADKHWVAKQIKDVYSISNALTIENEWDLASESIEKLAKERPNFNFAKYFSDRFYTHFAHGRERRNFTYKKLSEKKGEITLEYMMQILRSHQAEDFEPAKGSMRDICMHFGGLTRPSQTASSQISELYDDLPVHWFTGTSLPCLSIFKPIYFESGIPDLGEKPTNRYNPNSYWWRFELFHRKFQMNYKAYIEEFAKERKELQKKIIERERQVRENPSPEELRTLTEWAFEEEKKLIDKWNAKVKPGKLPFLYRRNWKKVNVRAGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMB9</accession>
    <name>F0LMB9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_02168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02168"/>
    <dbReference type="MEROPS" id="T01.002"/>
    <dbReference type="EnsemblBacteria" id="ADT85142">
        <property type="protein sequence ID" value="ADT85142"/>
        <property type="gene ID" value="TERMP_02168"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02168"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2163"/>
    <dbReference type="eggNOG" id="arCOG00970">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_2_2"/>
    <dbReference type="OMA" id="VDKTGPH"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03634">
        <property type="entry name" value="arc_protsome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT85142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="181" mass="20065" checksum="88D1CF3A837E0F9C" modified="2011-05-03" version="1">MRATIGNMVMSKNVTKIFQIDEHLALAGAGNVGDILSLVRMLRAETKLYRARVGREMSVKALATLTANILNGTKYFPYFGWFLIGGYDEKPNLYSVDMAGGMTEDKYVSAGSGMEFAYAVLENEYKEDMSVDEGVKLAVKAINTAIKRDVFTGDGILVVKITKEGYRELDKKEVDKILKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMG2</accession>
    <name>F0LMG2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pheromone shutdown protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468481.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02211"/>
    <dbReference type="EnsemblBacteria" id="ADT85185">
        <property type="protein sequence ID" value="ADT85185"/>
        <property type="gene ID" value="TERMP_02211"/>
    </dbReference>
    <dbReference type="GeneID" id="10042526"/>
    <dbReference type="KEGG" id="tba:TERMP_02211"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2206"/>
    <dbReference type="eggNOG" id="arCOG02142">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066331_0_0_2"/>
    <dbReference type="OMA" id="MSYLRYV"/>
    <dbReference type="OrthoDB" id="74729at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PTHR21530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="221" mass="25732" checksum="6DB1ED962E1D75F7" modified="2011-05-03" version="1">MSYLRYVKIIGTMHVSPESRERVRKVILEQKPHAIAIELDRRRFYAIQNPQKMSFEDAVKYGRKGIIQYVLTKVEEKLGEEFGMSPGGEMREAINLAGLLGIPLYLIDEDINTITMKILKAPFREKLLLILESLTVFLPFPRKEKERDLIKDFKIMMVQFKRRYPYLYRVLLEERNEIMAKNLMAIVDSLKAKGVKKPKVIAVVGLGHKRGVERILNSRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMI6</accession>
    <name>F0LMI6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467263.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00989"/>
    <dbReference type="EnsemblBacteria" id="ADT83965">
        <property type="protein sequence ID" value="ADT83965"/>
        <property type="gene ID" value="TERMP_00989"/>
    </dbReference>
    <dbReference type="GeneID" id="10041306"/>
    <dbReference type="KEGG" id="tba:TERMP_00989"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.992"/>
    <dbReference type="eggNOG" id="arCOG03685">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114057_1_1_2"/>
    <dbReference type="OMA" id="GPRPMEM"/>
    <dbReference type="OrthoDB" id="104170at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="131" mass="14861" checksum="6589EFF5B18C43C4" modified="2011-05-03" version="1">MITGKVRWIGNEKFEASVEEGGKIIFGEKGISPMRTLLLAVAGCTAIDVVMILQKMREPIKDLEIEISGERREEHPRIYKKVHIHYKIYGDVKPEKAKRAIELSQNKYCSASAHLKLSGTEVAYTFEIINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMM9</accession>
    <name>F0LMM9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467306.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01032"/>
    <dbReference type="EnsemblBacteria" id="ADT84008">
        <property type="protein sequence ID" value="ADT84008"/>
        <property type="gene ID" value="TERMP_01032"/>
    </dbReference>
    <dbReference type="GeneID" id="10041349"/>
    <dbReference type="KEGG" id="tba:TERMP_01032"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1035"/>
    <dbReference type="eggNOG" id="arCOG03817">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155678_0_0_2"/>
    <dbReference type="OMA" id="WAPLRYK"/>
    <dbReference type="OrthoDB" id="115614at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="131" mass="15762" checksum="CF057FDFCDF78058" modified="2011-05-03" version="1">MRLKIKPERGFGKIEVEINEDLWKKIEDLSERYKVGEDYILRIILTGEFKTPNEDVQNLEKKVQELEKKVYELEKKWAPLRYKAYGVSEDNKILAIELSGLLAENTQLKRFLRKKVEPNFELRKLIEYYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMN6</accession>
    <name>F0LMN6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPF0165 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467313.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01039"/>
    <dbReference type="EnsemblBacteria" id="ADT84015">
        <property type="protein sequence ID" value="ADT84015"/>
        <property type="gene ID" value="TERMP_01039"/>
    </dbReference>
    <dbReference type="GeneID" id="10041356"/>
    <dbReference type="KEGG" id="tba:TERMP_01039"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1042"/>
    <dbReference type="eggNOG" id="arCOG13111">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200885_0_1_2"/>
    <dbReference type="OMA" id="KEWDRDV"/>
    <dbReference type="OrthoDB" id="126557at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008203">
        <property type="entry name" value="AF2212-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024069">
        <property type="entry name" value="AF2212-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01954">
        <property type="entry name" value="DUF104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="63" mass="7352" checksum="30CD8DA7E68FA09B" modified="2011-05-03" version="1">MGIIEAVYENGVFRPLKKVKAPKKVKLMIIKDFERDLEEVFGILSEGIDVRELRKEWDRNASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMQ9</accession>
    <name>F0LMQ9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01062"/>
    <dbReference type="EnsemblBacteria" id="ADT84038">
        <property type="protein sequence ID" value="ADT84038"/>
        <property type="gene ID" value="TERMP_01062"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01062"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1065"/>
    <dbReference type="HOGENOM" id="CLU_3323174_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="38" mass="4558" checksum="CCF36A85BCE1B4A0" modified="2011-05-03" version="1">MALIYLVLKTIEKFFGRVSKIERDFEEIKKGLKEIKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMT1</accession>
    <name>F0LMT1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Adenylosuccinate synthetase</fullName>
            <shortName evidence="7">AMPSase</shortName>
            <shortName evidence="7">AdSS</shortName>
            <ecNumber evidence="7 8">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purA</name>
        <name evidence="9" type="ordered locus">TERMP_01084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="7 8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467358.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01084"/>
    <dbReference type="EnsemblBacteria" id="ADT84060">
        <property type="protein sequence ID" value="ADT84060"/>
        <property type="gene ID" value="TERMP_01084"/>
    </dbReference>
    <dbReference type="GeneID" id="10041401"/>
    <dbReference type="KEGG" id="tba:TERMP_01084"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1087"/>
    <dbReference type="eggNOG" id="arCOG04387">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_2"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="OrthoDB" id="35648at2157"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="252"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="42"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="284"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="324"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="339" mass="37357" checksum="9269888AF28051E5" modified="2011-05-03" version="1">MPSVIVVGGQWGDEGKGSVIAYLALHDKPDIIARGGVGTNAGHSVFINEKKYAVRQLPTGFMNREARLLVGAGVLVDPEVFFHELEHLKDFDVARRVGIDYRCSIIEPHHKEMDRKNGYLHGKIGTTGSGCGPANADRALRKARQAKDIKELEPYLTDVAQEVNDALDEGKLVLVEGTQGFGLSLYFGTYPYVTSKDTSASAIASDVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEAEKMGLVEYGTVTGRRRRVGWFDFEFARYSAKINGATMLAITMLDKYDKEAFGVTDYDKLPMRAKEFIEEIEDKVGVPVGLIRTGPELEHIIDLRENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMT6</accession>
    <name>F0LMT6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L18Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein L20e</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein LX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl18a</name>
        <name evidence="3" type="synonym">rpl20e</name>
        <name evidence="3" type="synonym">rplX</name>
        <name evidence="5" type="ordered locus">TERMP_01089</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Binds 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467363.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01089"/>
    <dbReference type="EnsemblBacteria" id="ADT84065">
        <property type="protein sequence ID" value="ADT84065"/>
        <property type="gene ID" value="TERMP_01089"/>
    </dbReference>
    <dbReference type="GeneID" id="26136544"/>
    <dbReference type="KEGG" id="tba:TERMP_01089"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1092"/>
    <dbReference type="eggNOG" id="arCOG04175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177460_0_1_2"/>
    <dbReference type="OMA" id="MVFTKEY"/>
    <dbReference type="OrthoDB" id="125208at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_L18Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="50S_L18Ae/Ribosomal_L18a/L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_L18a//L18Ae/LX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18A" evidence="4">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="78" mass="9300" checksum="4DC1B3231FA7183D" modified="2011-05-03" version="1">MEVKVYRVKGIFERNGKKQKFTKEYRAVKPEDVVELVYSEIGSKHRVKRTKIWIEKIEEIKPEEAENPVVRRLSLELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMU4</accession>
    <name>F0LMU4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-binding protein TERMP_01097</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467371.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01097"/>
    <dbReference type="EnsemblBacteria" id="ADT84073">
        <property type="protein sequence ID" value="ADT84073"/>
        <property type="gene ID" value="TERMP_01097"/>
    </dbReference>
    <dbReference type="GeneID" id="26136551"/>
    <dbReference type="KEGG" id="tba:TERMP_01097"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1100"/>
    <dbReference type="eggNOG" id="arCOG04179">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122978_3_0_2"/>
    <dbReference type="OMA" id="KPQFGEQ"/>
    <dbReference type="OrthoDB" id="130316at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00026">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022889">
        <property type="entry name" value="DNA_bind_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PTHR10840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="SSF46950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="112" mass="13382" checksum="59E59B1E579B32B8" modified="2011-05-03" version="1">MAEDIEEIRKRKLMELQRRLAEQQKAQEEAARQQAELEAQIQAILRRILTPEARERLSRVKLVRPELAQQVELILVQLYQAGQIREKIDDAKLKKILAQIDARTRREFRIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMW7</accession>
    <name>F0LMW7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl24e</name>
        <name evidence="6" type="ordered locus">TERMP_01120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467394.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01120"/>
    <dbReference type="EnsemblBacteria" id="ADT84096">
        <property type="protein sequence ID" value="ADT84096"/>
        <property type="gene ID" value="TERMP_01120"/>
    </dbReference>
    <dbReference type="GeneID" id="10041437"/>
    <dbReference type="KEGG" id="tba:TERMP_01120"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1123"/>
    <dbReference type="eggNOG" id="arCOG01950">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190191_0_0_2"/>
    <dbReference type="OMA" id="GTGKMYV"/>
    <dbReference type="OrthoDB" id="125162at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00773">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023438">
        <property type="entry name" value="Ribosomal_L24e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_L24e-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_L24e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="PTHR10792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRASH" evidence="5">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="69" mass="8350" checksum="9375DBF855C49677" modified="2011-05-03" version="1">MARWNVCSYCGKEFEPGTGKMFVRNDGRVFFFCSSKCEKYFLMGRNPRKLKWTKAFQEARLQRARSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN06</accession>
    <name>F0LN06_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine recombinase XerA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xerA</name>
        <name evidence="7" type="ordered locus">TERMP_01159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 'phage' integrase family. XerA subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="ADT84135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01159"/>
    <dbReference type="EnsemblBacteria" id="ADT84135">
        <property type="protein sequence ID" value="ADT84135"/>
        <property type="gene ID" value="TERMP_01159"/>
    </dbReference>
    <dbReference type="GeneID" id="10041476"/>
    <dbReference type="KEGG" id="tba:TERMP_01159"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1162"/>
    <dbReference type="eggNOG" id="arCOG01241">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_5_2"/>
    <dbReference type="OMA" id="TKVTVEH"/>
    <dbReference type="OrthoDB" id="57897at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CB"/>
    </dbReference>
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        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
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        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033686">
        <property type="entry name" value="XerA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0229">DNA integration</keyword>
    <keyword evidence="2 3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="90"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="276" mass="31909" checksum="477CCABDB112845E" modified="2011-05-03" version="1">MNIEEFEMYLELEGKSQNTVRMYSYYVKKFLEEGNDLNARSALRFLAVLKRSGYSNKSLNLVVQALKAYFRFEGLEEEAKKIKSPKVPRSLPKSLTKEEVKKLLSVIPPTRKRDRLIVLLLYGSGLRVSELCNLKINDVDFKRSLIIVRGGKGGKDRIVPVPGALLKEIEDYLKMRNDDSEYLLVEERRSRKDRLSPKTVWYILNKYGKKAGIKVTPHMLRHSFATHMLENGIDIRVIQEILGHSNLSTTQIYTKVTVEHLRRAQEKAKLIESLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="1 2">
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ADT84174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="TERMP_01198"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01198"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1201"/>
    <dbReference type="HOGENOM" id="CLU_3283045_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="40" mass="4838" checksum="24FCEABF0D403CA3" modified="2011-05-03" version="1">MKRAGERYLQELWRVMLAFVLTPEEDAKDKRVKKIEFAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN89</accession>
    <name>F0LN89_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTBMP1</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
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        </source>
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    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="111" mass="13034" checksum="469A2C232DB6B037" modified="2011-05-03" version="1">MAEVRLLDLPARAKKYIKNKEELEKEIMKDLIDNLPTSIKRIFFDTFNEYQEKKSKEAIITHDADKLDMLLQAIEYSKQGYNTEEWIKDVLSSLITPTAKRIADVILRCKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LNA0</accession>
    <name>F0LNA0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02266</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
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        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
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        </source>
    </reference>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_013747461.1">
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02266"/>
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        <property type="gene ID" value="TERMP_02266"/>
    </dbReference>
    <dbReference type="GeneID" id="10549090"/>
    <dbReference type="KEGG" id="tba:TERMP_02266"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2260"/>
    <dbReference type="HOGENOM" id="CLU_2646111_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="76" mass="8806" checksum="7C7325AA6AD60363" modified="2011-05-03" version="1">MKELRCAICGQEITHNEVGFIFKDGEVMCVYCLDEALLEIQDEEIPPEEVNHMIREFLKSLQLPKLPEKAFKVVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGV6</accession>
    <name>F0LGV6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sorbitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466293.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00017"/>
    <dbReference type="EnsemblBacteria" id="ADT82995">
        <property type="protein sequence ID" value="ADT82995"/>
        <property type="gene ID" value="TERMP_00017"/>
    </dbReference>
    <dbReference type="GeneID" id="10040336"/>
    <dbReference type="KEGG" id="tba:TERMP_00017"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.16"/>
    <dbReference type="eggNOG" id="arCOG01459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_2"/>
    <dbReference type="OrthoDB" id="67758at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT82995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="340" mass="37315" checksum="6E1DC15803327C22" modified="2011-05-03" version="1">MKALVKYARGPWNIELRDVPEPKSREGYIIVDVKAAGICASDLLIIHDKGHPYEPPVILGHEFSGVIAEDKGEWKKGDRVTSQTTFSTCGKCYLCKSGYPQHCPEKKVIGIKANGAFTEKILVPVSGLHRIPKNMSFEEAAITEIGADVVYALNERANLQPGEFVVIFGPGAVGLFAVQVAKATGAEVAIVGTKIERDEYRLKLAEKLGADHVLYAEEDPVSEVKYLTNGKGADIAFEASGAAPAVLQALQITRNLGRIIAFGIPKGSVTVPWNMIVFKAVEVIFHLSSSWTSWEKILYLMREGKVKTKPLISKPFRLEEWEKAIKEAETGFSPRVILKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGX6</accession>
    <name>F0LGX6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagella protein FlaG-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467482.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01208"/>
    <dbReference type="EnsemblBacteria" id="ADT84184">
        <property type="protein sequence ID" value="ADT84184"/>
        <property type="gene ID" value="TERMP_01208"/>
    </dbReference>
    <dbReference type="GeneID" id="10041525"/>
    <dbReference type="KEGG" id="tba:TERMP_01208"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1210"/>
    <dbReference type="eggNOG" id="arCOG01822">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134827_1_0_2"/>
    <dbReference type="OMA" id="YTFYIKN"/>
    <dbReference type="OrthoDB" id="108228at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42200">
        <property type="entry name" value="PTHR42200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Arch_flagellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="153" mass="16675" checksum="3257A735829C9744" modified="2011-05-03" version="1">MASNVASELILFIASLLVAGMVAGGLYVVTQDISDGITVRGKDLAYNLRLNFEIINDPENIPTDNTGAYIFYIKNIGKVPFTFESNSIIVFIDGNMIPSSNLTFVNLNNPTSNQLYPYDVGEIHVATSLSSGYHKIVVVLSNGKQRALIFRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGZ1</accession>
    <name>F0LGZ1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467497.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84199">
        <property type="protein sequence ID" value="ADT84199"/>
        <property type="gene ID" value="TERMP_01223"/>
    </dbReference>
    <dbReference type="GeneID" id="26136703"/>
    <dbReference type="KEGG" id="tba:TERMP_01223"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1224"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2379578_0_0_2"/>
    <dbReference type="OrthoDB" id="137692at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="94" mass="11152" checksum="1FAEB8338010E6BF" modified="2011-05-03" version="1">MKVILFISAAEEKATEVQRQLWKRGLIEEIYQTVGDSNIVAVIKVENERSLRDIALEISQMRGVYSVRIYPVAEHHTKEELKEYWNSRQQIWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGZ9</accession>
    <name>F0LGZ9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the archaeal NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467505.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01231"/>
    <dbReference type="EnsemblBacteria" id="ADT84207">
        <property type="protein sequence ID" value="ADT84207"/>
        <property type="gene ID" value="TERMP_01231"/>
    </dbReference>
    <dbReference type="GeneID" id="26136711"/>
    <dbReference type="KEGG" id="tba:TERMP_01231"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1232"/>
    <dbReference type="eggNOG" id="arCOG00972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108783_0_0_2"/>
    <dbReference type="OMA" id="NSVWVSH"/>
    <dbReference type="OrthoDB" id="90722at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02166">
        <property type="entry name" value="NMNAT_Archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00243">
        <property type="entry name" value="NMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006418">
        <property type="entry name" value="NMN_Atrans_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01527">
        <property type="entry name" value="arch_NMN_Atrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="187" mass="21540" checksum="196D4D7B999DEC44" modified="2011-05-03" version="1">MPKRGLFVGRFQPVHNGHIKALEFVFSQVDEVIIGIGSAQASHTLKNPFTTSERMEMLIRALDEAGFKRKYYLIPLPDINFNAIWATYVVSMVPKFDVVFTGNSLVAQLFREKGYEVIVQPMFRKDILSATEIRKRMIEGKPWEELVPKSVAEFIKEIKGVERIRMLATNLEKNEKELQAPIRIPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH08</accession>
    <name>F0LH08_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467514.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01240"/>
    <dbReference type="EnsemblBacteria" id="ADT84216">
        <property type="protein sequence ID" value="ADT84216"/>
        <property type="gene ID" value="TERMP_01240"/>
    </dbReference>
    <dbReference type="GeneID" id="25394637"/>
    <dbReference type="KEGG" id="tba:TERMP_01240"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1242"/>
    <dbReference type="eggNOG" id="arCOG00833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1154402_0_0_2"/>
    <dbReference type="OrthoDB" id="58973at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="244" mass="28109" checksum="2D18C0C97ADBF09B" modified="2011-05-03" version="1">MIRRAKIEDKSILEEIHGGEPPWENFEVYLKAIRDSGGDIFLYGDKGEIELLPFNGKAHIHVLWVQEGYRGKGIGSKLLAFAEKWAKKRGLKGLSVIPEDGNAMRFYMKNGFGFKEWQVKVIKDVEGCDVKVESHYDNPPKFPNVSAVYTSGLFLWNLHKKAPRVRFRDFTILLIDEGSCVNAVIYGERLNRRIVKVAECLAGKIGKKLFLQVWMKDWKILEEEGFKKSVKLSGWRRFSLEPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH33</accession>
    <name>F0LH33_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mut7-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467539.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01265"/>
    <dbReference type="EnsemblBacteria" id="ADT84241">
        <property type="protein sequence ID" value="ADT84241"/>
        <property type="gene ID" value="TERMP_01265"/>
    </dbReference>
    <dbReference type="GeneID" id="10041582"/>
    <dbReference type="KEGG" id="tba:TERMP_01265"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1268"/>
    <dbReference type="eggNOG" id="arCOG04290">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112469_1_0_2"/>
    <dbReference type="OMA" id="CGQIYWP"/>
    <dbReference type="OrthoDB" id="96038at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="152" mass="17939" checksum="0391789593A5BDE4" modified="2011-05-03" version="1">MKPKLIADMMLGRLARWLRLYGYDTVYGVKDDDEIIEIAKKEGRIILTRDEELAKRAKNAILISSNKFEEQIKQLMELGFTFNELFPENARCPKCNGLIKEIPKEKIKDKVPPGVYEKYNEFYICTECGQIYWPGRQWQEMVKIDKKLRESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH48</accession>
    <name>F0LH48_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466308.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00032"/>
    <dbReference type="EnsemblBacteria" id="ADT83010">
        <property type="protein sequence ID" value="ADT83010"/>
        <property type="gene ID" value="TERMP_00032"/>
    </dbReference>
    <dbReference type="GeneID" id="10040351"/>
    <dbReference type="KEGG" id="tba:TERMP_00032"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.31"/>
    <dbReference type="eggNOG" id="arCOG02249">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_1_2_2"/>
    <dbReference type="OMA" id="MCYRYIF"/>
    <dbReference type="OrthoDB" id="84044at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="218" mass="24683" checksum="BECE1C2757BA2A05" modified="2011-05-03" version="1">MYLPFLLIYALAVVTRKSLSELAYFGIILIGLIILLRPKKSIFKHLGFLLGFEGLLFILALFNPGEPLVSTPIGAITKEGLHSFFLLLGKAFLSSSAVVVTSNSLGFSRLLAEMEELRFPRILILTLAFTYRYLDLFKEEALRMKRALDSRAFGIGKKEYYRKLGMLISEIFVRAYIRNDKIYKAMLSRCFGEFPKFERNKSLVPLILSVIALAGVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH53</accession>
    <name>F0LH53_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466313.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00037"/>
    <dbReference type="EnsemblBacteria" id="ADT83015">
        <property type="protein sequence ID" value="ADT83015"/>
        <property type="gene ID" value="TERMP_00037"/>
    </dbReference>
    <dbReference type="GeneID" id="10040356"/>
    <dbReference type="KEGG" id="tba:TERMP_00037"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.36"/>
    <dbReference type="eggNOG" id="arCOG01961">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_9_3_2"/>
    <dbReference type="OMA" id="QIGMFVL"/>
    <dbReference type="OrthoDB" id="47913at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="17"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="446" mass="49011" checksum="B89A18F7A3D69664" modified="2011-05-03" version="1">MTSNVLVPDVDTIAYILFMVLAVGMISLLISRRFNVSYVPLFVFFGILAGPVLGLINRSLAHELFSYVRVFGLVMILFAEGHTLSWKMLKRNMGTIAVLDTVGLLITAVIAGIAFSVLFHTPFIVGFLFGAIIGATDPATLIPLFRQYKVKEDIETVIVTESIFNDPLGIVLTSVAIALLLPQAPSAAVLESIARYISIYPAAVVFFLYELGMSIGIGVLLGVFGYYFIKKTGIKGFPEIEVFALMLAFGGFLLGEYVKASGYLVATVTGIVLGNHKVFFRDNPRTVKRIMRAIEKEVHFNESLATLATIFIFALLGASLDMSVITSNLLPGMILAFVVILIARPIAVLPILPWWKPKEYLFIALEGPRGVVPSALASLPLTLGLVYHDQQMIQWGEIILGATVITVLVSVIVETLWVPLLRERLLEVESIRKRMIRSGYKPKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH54</accession>
    <name>F0LH54_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466314.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00038"/>
    <dbReference type="EnsemblBacteria" id="ADT83016">
        <property type="protein sequence ID" value="ADT83016"/>
        <property type="gene ID" value="TERMP_00038"/>
    </dbReference>
    <dbReference type="GeneID" id="26137891"/>
    <dbReference type="KEGG" id="tba:TERMP_00038"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.37"/>
    <dbReference type="eggNOG" id="arCOG01700">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_0_2_2"/>
    <dbReference type="OMA" id="YELTTIM"/>
    <dbReference type="OrthoDB" id="52310at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="285" mass="32147" checksum="AB890125BA8710EC" modified="2011-05-03" version="1">MEFFYTYETIKTALPLVDTEKADFVIFGVPFDSTTSYKPGARFGPTLIRQATINLESYILDYDVDLSELRIADIGDIEIVAGNPLGTIKRIIETVRELKESNPKAMPIMLGGEHSMTYALVRALRPKSYIVFDAHLDLRDEYEGNPWNHACVARRISELGISMAEFGIRSGIREEVEYAKERNIKWIHARQYSVEEFKGIVKNLPEPVYVSVDIDVFDLSMVPSTGTPEAGGLEFWEVIEALEWLTEKKKIVGFDIMEVAGTELGDITALTGAKLMFYLIGMLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH95</accession>
    <name>F0LH95_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Translation initiation factor 2 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">aIF2-beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 9">eIF-2-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">eif2b</name>
        <name evidence="11" type="ordered locus">TERMP_00079</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterotrimer composed of an alpha, a beta and a gamma chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466355.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00079"/>
    <dbReference type="EnsemblBacteria" id="ADT83057">
        <property type="protein sequence ID" value="ADT83057"/>
        <property type="gene ID" value="TERMP_00079"/>
    </dbReference>
    <dbReference type="GeneID" id="10040398"/>
    <dbReference type="KEGG" id="tba:TERMP_00079"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.79"/>
    <dbReference type="eggNOG" id="arCOG01640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026663_3_1_2"/>
    <dbReference type="OMA" id="NVKHHKS"/>
    <dbReference type="OrthoDB" id="96453at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00232">
        <property type="entry name" value="eIF_2_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004458">
        <property type="entry name" value="TIF2_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="PTHR23001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="SSF100966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="SSF75689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00311">
        <property type="entry name" value="aIF-2beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF2B_5" evidence="10">
        <location>
            <begin position="35"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="148" mass="17024" checksum="FEE5A735748A389A" modified="2011-05-03" version="1">MGEKGIEKVEYDYYDYEKLLEKAYDELPENVKHHTSRFEVPVAIVTIEGNKTIIENFKDIAEAMNRDPNHLLKFILREVATAGTLEGRRVILQGRFTPYLIANKMKKYLKEYVICPVCGSPDTKITKKGRFHYLKCEACGAETPIAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHE5</accession>
    <name>F0LHE5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467570.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01297"/>
    <dbReference type="EnsemblBacteria" id="ADT84272">
        <property type="protein sequence ID" value="ADT84272"/>
        <property type="gene ID" value="TERMP_01297"/>
    </dbReference>
    <dbReference type="GeneID" id="10041613"/>
    <dbReference type="KEGG" id="tba:TERMP_01297"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1299"/>
    <dbReference type="eggNOG" id="arCOG07118">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1275254_0_0_2"/>
    <dbReference type="OMA" id="TIFNHEI"/>
    <dbReference type="OrthoDB" id="67407at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="236" mass="27336" checksum="97D898901FFF6B34" modified="2011-05-03" version="1">MEVDPLEILKESSKRISPTLIEYEIGSEIEIILYTLIKKLRQEYQNFIIISFHDAYLVLRRYLENVFSETEVNTAFDGAHLISVNPILETEENRPQDIIKSTHHDIIVGRILEATSKINGESLFIILGLDFFGIRIGKDELIDLFPALVSTIGRKKNNNVIMTLNVKVFPQSLVEIVNSFAFNVAHVGIELQDKEIRRYITLIRTVFLEYNLKKWYYTLLGKKLVFKRVNSEGLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHF2</accession>
    <name>F0LHF2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467577.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01304"/>
    <dbReference type="EnsemblBacteria" id="ADT84279">
        <property type="protein sequence ID" value="ADT84279"/>
        <property type="gene ID" value="TERMP_01304"/>
    </dbReference>
    <dbReference type="GeneID" id="10041620"/>
    <dbReference type="KEGG" id="tba:TERMP_01304"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1305"/>
    <dbReference type="eggNOG" id="arCOG03686">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100275_2_1_2"/>
    <dbReference type="OMA" id="PVEYYLA"/>
    <dbReference type="OrthoDB" id="94993at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="138" mass="15311" checksum="CFB7859F3102E988" modified="2011-05-03" version="1">MPTIKVSVIGESVSPTRMIVKGKKTEYVVDKDESSPLEYILAAFAGCINIVGFMVAKDMNLDIEKIIVEISGKLNTDKLMGKNVEDRAGYKEIKVKVKVQGNVEEGKLKEWIAKVEERCPIGDNIMHETPVCVEVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHG8</accession>
    <name>F0LHG8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01320"/>
    <dbReference type="EnsemblBacteria" id="ADT84295">
        <property type="protein sequence ID" value="ADT84295"/>
        <property type="gene ID" value="TERMP_01320"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01320"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1321"/>
    <dbReference type="HOGENOM" id="CLU_3228010_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="43" mass="4900" checksum="8F56B0E9A8FB6602" modified="2011-05-03" version="1">MVSPLNELCFKVSLQHGAQRASKEKWNNVIILKTKTVKPIDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHH7</accession>
    <name>F0LHH7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">TERMP_01329</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467602.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01329"/>
    <dbReference type="EnsemblBacteria" id="ADT84304">
        <property type="protein sequence ID" value="ADT84304"/>
        <property type="gene ID" value="TERMP_01329"/>
    </dbReference>
    <dbReference type="GeneID" id="10041645"/>
    <dbReference type="KEGG" id="tba:TERMP_01329"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1329"/>
    <dbReference type="eggNOG" id="arCOG01481">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043773_0_0_2"/>
    <dbReference type="OMA" id="EVRWTLD"/>
    <dbReference type="OrthoDB" id="56885at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01571">
        <property type="entry name" value="NAPRTase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035809">
        <property type="entry name" value="NAPRTase_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="11">
        <location>
            <begin position="51"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="115"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase_C" evidence="12">
        <location>
            <begin position="342"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT84304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="390" mass="43360" checksum="7F4645E5AE2C7448" modified="2011-05-03" version="1">MKSFYIAHEDDIKAGKTTDVYFIRTKKILEAKGIHKKVLADVSTTSLPKSWKWGVLAGVEEVAKLLEGLPVNVYSMPEGTIFHPYEPVMQIEGYYEEFGIYETALLGMLSQASGIATAALRVKIAAKFKPVYSFGIRHMHPAIAPMIDRSAFIGGCDGVSGVLGAEMMGEKPVGTMPHALILTVGDQVKAWKYFDEVVEPEVPRTALIDTFCDEKFEALMAAETLGEKLFAVRLDTPSSRRGNFKRIIEEVRWELDLRGYTHVKIFLSGGLDEESIKELVDVADAFGVGGSIASAKPVDFSLDIVEIEGKPITKRGKLSGRKQVYRCEKGHYHRVPVEKKLERCPVCGAKVEPLLKPLIENGEIVAELPKAREIREYVLEQARKFNLSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHJ3</accession>
    <name>F0LHJ3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase</fullName>
            <shortName evidence="6">PvlArgDC</shortName>
            <ecNumber evidence="6">4.1.1.19</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase subunit beta</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase subunit alpha</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="6" type="primary">pdaD</name>
        <name evidence="7" type="ordered locus">TERMP_01345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H(+) + L-arginine = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="6">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PdaD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467618.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01345"/>
    <dbReference type="EnsemblBacteria" id="ADT84320">
        <property type="protein sequence ID" value="ADT84320"/>
        <property type="gene ID" value="TERMP_01345"/>
    </dbReference>
    <dbReference type="GeneID" id="26136829"/>
    <dbReference type="KEGG" id="tba:TERMP_01345"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1345"/>
    <dbReference type="eggNOG" id="arCOG04490">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114389_2_0_2"/>
    <dbReference type="OMA" id="AAALWYK"/>
    <dbReference type="OrthoDB" id="98606at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01404">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016104">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016105">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase_sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002724">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40438">
        <property type="entry name" value="PTHR40438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01862">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005216">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01170">
        <property type="entry name" value="Pyruvoyl-dependent_arginine_de"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56271">
        <property type="entry name" value="SSF56271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00286">
        <property type="entry name" value="TIGR00286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_5023355664" description="Pyruvoyl-dependent arginine decarboxylase subunit beta" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023355665" description="Pyruvoyl-dependent arginine decarboxylase subunit alpha" evidence="6">
        <location>
            <begin position="44"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic)" evidence="6">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="6">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="157" mass="16945" checksum="7CA0E010673FCFA5" modified="2011-05-03" version="1">MSWTTPKKAIMLAASAEGGTKLNAFDNALLKMGIGNVNLVKLSSVIPSHIEWIEKVPEIPIGMLLPTVYAHIESDEPGTTISAALGVGISEGNQGGLIYEYSGYCTKEEATEMVKRMVEEGFRIRGWKLKEFKVAAAEITVKNKPAAAVAAVVMFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHJ9</accession>
    <name>F0LHJ9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multisubunit sodium/hydrogen antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467624.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01351"/>
    <dbReference type="EnsemblBacteria" id="ADT84326">
        <property type="protein sequence ID" value="ADT84326"/>
        <property type="gene ID" value="TERMP_01351"/>
    </dbReference>
    <dbReference type="GeneID" id="44120410"/>
    <dbReference type="KEGG" id="tba:TERMP_01351"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1351"/>
    <dbReference type="eggNOG" id="arCOG03077">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171166_1_0_2"/>
    <dbReference type="OMA" id="TAILADW"/>
    <dbReference type="OrthoDB" id="117506at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="81" mass="9127" checksum="7E5A6D1B38CD531C" modified="2011-05-03" version="1">MRRIVAALIVLSLAFTLLQLDYSKVEGGSYEYYISHWQEVNIPNLVTAILADWRAYDTLGEATLLFTAVIGFYLLLGGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHV3</accession>
    <name>F0LHV3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator Lrp/AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01378"/>
    <dbReference type="EnsemblBacteria" id="ADT84353">
        <property type="protein sequence ID" value="ADT84353"/>
        <property type="gene ID" value="TERMP_01378"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01378"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1378"/>
    <dbReference type="eggNOG" id="arCOG01585">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_4_1_2"/>
    <dbReference type="OMA" id="YFFCCET"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013603">
        <property type="entry name" value="TRASH_TR_C_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08394">
        <property type="entry name" value="Arc_trans_TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="205" mass="24166" checksum="D228EB945C8546EB" modified="2011-05-03" version="1">MKLDEIDLKLIYLLMDNSRLSISELAERLGVSRPTVKSRLDRLEKEGVIQRYTIKLNPELQRASNVVALIIKTDEPEKLQEFEEIIEINRFTSKKYLIKVAVEDMEGLRNVIEGAGFEVLEIMPILESIEKEYPPKVKVSFKCDYCGKEITGEPIVYKYRNKVYFFCCETCFREFKKARENLEKFKLKEKDKVEHAHEHEHHAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHV7</accession>
    <name>F0LHV7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467655.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01382"/>
    <dbReference type="EnsemblBacteria" id="ADT84357">
        <property type="protein sequence ID" value="ADT84357"/>
        <property type="gene ID" value="TERMP_01382"/>
    </dbReference>
    <dbReference type="GeneID" id="10041698"/>
    <dbReference type="KEGG" id="tba:TERMP_01382"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1382"/>
    <dbReference type="eggNOG" id="arCOG10112">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2056142_0_0_2"/>
    <dbReference type="OMA" id="MMDDEMY"/>
    <dbReference type="OrthoDB" id="126952at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="114" mass="13028" checksum="583800F352BE756D" modified="2011-05-03" version="1">MEWKSILIGFIIGALIAIPIGMAHTGTFDNAEEKGLWRGFSPMMGMGHGMGMMGYGMHGMMDDEMYAQMEEYMASGNFTEMHEEMEPIMEKYMGSNWKEMHEYCEKAMGIEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHW4</accession>
    <name>F0LHW4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467662.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01389"/>
    <dbReference type="EnsemblBacteria" id="ADT84364">
        <property type="protein sequence ID" value="ADT84364"/>
        <property type="gene ID" value="TERMP_01389"/>
    </dbReference>
    <dbReference type="GeneID" id="10041705"/>
    <dbReference type="KEGG" id="tba:TERMP_01389"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1389"/>
    <dbReference type="eggNOG" id="arCOG07402">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1478987_0_0_2"/>
    <dbReference type="OMA" id="KMALKQY"/>
    <dbReference type="OrthoDB" id="78502at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="188" mass="21478" checksum="9C425B55807B46AF" modified="2011-05-03" version="1">MVKLWKSKEEKEIERKIRMRKAKMALKQYINNLENLKHKIFLQGKEAAKLGDEALLKRSAMKYLAIEERIKQAKRLLLLMEEAEIQRELVKVSADFIQFSKDVVKSIAEGPGAEDVAKMQVEFEKAMGKVENLEEALNTMIDLTSESILTGEFDLETVEMAEGLMVSSVGEDLEPAKRLKEIEDMMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHW5</accession>
    <name>F0LHW5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PrpC-like protein serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01390"/>
    <dbReference type="EnsemblBacteria" id="ADT84365">
        <property type="protein sequence ID" value="ADT84365"/>
        <property type="gene ID" value="TERMP_01390"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01390"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1390"/>
    <dbReference type="eggNOG" id="arCOG05302">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034545_4_2_2"/>
    <dbReference type="OMA" id="DACIFAV"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="188" mass="20647" checksum="8214777865D374BD" modified="2011-05-03" version="1">MVVEALRETFERGYTRGIGVEGVKGLLLRAYEDAHRRIVEMSPGPGKMGTTLTTAFVRNRMAVVANTGDSRAYLVQEGKIVAKTRDHSVVQELIERGIISEEEAREHPMRHVVTKALGVDLGVDTYVWELKAGDVLLLSTDGLHDYIDEGIIGKLVFGSDPRTAAEALIGEALKVTEDNVTVVVFREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHY0</accession>
    <name>F0LHY0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467678.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01405"/>
    <dbReference type="EnsemblBacteria" id="ADT84380">
        <property type="protein sequence ID" value="ADT84380"/>
        <property type="gene ID" value="TERMP_01405"/>
    </dbReference>
    <dbReference type="GeneID" id="10041721"/>
    <dbReference type="KEGG" id="tba:TERMP_01405"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1405"/>
    <dbReference type="eggNOG" id="arCOG00273">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042632_1_0_2"/>
    <dbReference type="OMA" id="EPHSHWH"/>
    <dbReference type="OrthoDB" id="80550at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EamA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="1">
        <location>
            <begin position="165"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="300" mass="32565" checksum="1EB5F6D783B8EC4F" modified="2011-05-03" version="1">MTYHYGYVGAVLAALLFGMGSTLNKIALREVHPMIIAGSIYLTAGIVLMLLRFTPLKDKILGRLEFKVKTQEYFSGRDFLLLTLIVLFGSFLAPLSFMFGLNKTTAVNASLLLNTETLFTVLIALLVFKEKASRRSITGILLILIGVAVISTENFRGVEMSRGILGNILIILAGLSWAVDNNLSKLLSVKRDLLLVTSLKGLFGGSALLVLASLLGIPFYIPLQSIPYILTVGAFSIGFSIVLFLFALREIGAMKTGAIFSTSSLIGAFFAFLLLGESFTAVKAFFGVLMFFGVYLLSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI01</accession>
    <name>F0LI01_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01426"/>
    <dbReference type="EnsemblBacteria" id="ADT84401">
        <property type="protein sequence ID" value="ADT84401"/>
        <property type="gene ID" value="TERMP_01426"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01426"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1426"/>
    <dbReference type="eggNOG" id="arCOG02625">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065947_2_2_2"/>
    <dbReference type="OMA" id="GYRWGSC"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="198" mass="23422" checksum="D8687B66DB77DA54" modified="2011-05-03" version="1">MRIYVHPEGYLRIVSPTQNVKPILKSKEHWILKNLEKVERGKTLASRGFPLFGRFYEVRECRKTEIFNDVICVSNLESLKRKIKRELKKKIDKIIEKRTEEIGKKPNKMFIRVQKNKWGSCSSKGNLSLNIALAALPEELLDYVVTHELAHLLELNHSKHFWKLVAKIHPDYKKKRDELKLWWVIVNNNELWKKILGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI59</accession>
    <name>F0LI59_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466511.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00236"/>
    <dbReference type="EnsemblBacteria" id="ADT83213">
        <property type="protein sequence ID" value="ADT83213"/>
        <property type="gene ID" value="TERMP_00236"/>
    </dbReference>
    <dbReference type="GeneID" id="10040554"/>
    <dbReference type="KEGG" id="tba:TERMP_00236"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.236"/>
    <dbReference type="eggNOG" id="arCOG03784">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2406506_0_0_2"/>
    <dbReference type="OMA" id="HHWAGDL"/>
    <dbReference type="OrthoDB" id="112915at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="92" mass="10688" checksum="8ADF1BF0D820EA35" modified="2011-05-03" version="1">MAYIGFARTNFGPYETYERILEELGKRGFDITFSKHHWMGDAPFGLIIADSDKGKIAVRWSLGKEFELKLEEVSDEDWDEFIEDTLEYLSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI69</accession>
    <name>F0LI69_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rps12</name>
        <name evidence="5" type="ordered locus">TERMP_00246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466521.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00246"/>
    <dbReference type="EnsemblBacteria" id="ADT83223">
        <property type="protein sequence ID" value="ADT83223"/>
        <property type="gene ID" value="TERMP_00246"/>
    </dbReference>
    <dbReference type="GeneID" id="26135584"/>
    <dbReference type="KEGG" id="tba:TERMP_00246"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.246"/>
    <dbReference type="eggNOG" id="arCOG04255">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115574_0_1_2"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="OrthoDB" id="85293at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_A">
        <property type="entry name" value="Ribosomal_S12_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022863">
        <property type="entry name" value="Ribosomal_S12_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_S23_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="147" mass="16392" checksum="8BFFCCD8D7BBDC42" modified="2011-05-03" version="1">MPGKKAPYGEFAGRKLKLKRKKFRWSDITFKRRVLRLKEKSDPLEGAPQARGIVLEKIAVEAKQPNSGMRKAVRVQLIKNGKVVTAFCPGDGAINHIDEHDEVIIEGIGGPKGGSMGDIPGIRYKVVKVNRVSLKELVKGRKEKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIC5</accession>
    <name>F0LIC5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane bound hydrogenase MbhE-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467753.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01480"/>
    <dbReference type="EnsemblBacteria" id="ADT84455">
        <property type="protein sequence ID" value="ADT84455"/>
        <property type="gene ID" value="TERMP_01480"/>
    </dbReference>
    <dbReference type="GeneID" id="10041796"/>
    <dbReference type="KEGG" id="tba:TERMP_01480"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1480"/>
    <dbReference type="eggNOG" id="arCOG03077">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171166_0_0_2"/>
    <dbReference type="OMA" id="EPPHAEM"/>
    <dbReference type="OrthoDB" id="117506at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="91" mass="10136" checksum="68B2F7F73FBF47DE" modified="2011-05-03" version="1">MRTSLGLLAFIGFTLFLLAAMISIRPFGEPPHREMDDWFITHAQIEASANNVVTSIVFDYRGFDTLGEATVLFTAVSGVLMVLRRKEGTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIC8</accession>
    <name>F0LIC8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multiple resistance and pH regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467756.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01483"/>
    <dbReference type="EnsemblBacteria" id="ADT84458">
        <property type="protein sequence ID" value="ADT84458"/>
        <property type="gene ID" value="TERMP_01483"/>
    </dbReference>
    <dbReference type="GeneID" id="26136971"/>
    <dbReference type="KEGG" id="tba:TERMP_01483"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1483"/>
    <dbReference type="eggNOG" id="arCOG03121">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125825_1_2_2"/>
    <dbReference type="OMA" id="NIVYLML"/>
    <dbReference type="OrthoDB" id="128222at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34702">
        <property type="entry name" value="PTHR34702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="91" mass="9808" checksum="5BCCCBC4014915CA" modified="2011-05-03" version="1">MNVVSAFMVALILLLFSAMLTLIRLILGPTIPDRAVALDSMTTTTAGAMVLYGVVTKQPVFIDVALVYAVLSYIATLYIARYLVKKKVGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIK6</accession>
    <name>F0LIK6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466578.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00303"/>
    <dbReference type="EnsemblBacteria" id="ADT83280">
        <property type="protein sequence ID" value="ADT83280"/>
        <property type="gene ID" value="TERMP_00303"/>
    </dbReference>
    <dbReference type="GeneID" id="10040621"/>
    <dbReference type="KEGG" id="tba:TERMP_00303"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.303"/>
    <dbReference type="eggNOG" id="arCOG02217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175270_0_0_2"/>
    <dbReference type="OMA" id="YLIKRVR"/>
    <dbReference type="OrthoDB" id="131018at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039709">
        <property type="entry name" value="VapB3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42244">
        <property type="entry name" value="PTHR42244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="74" mass="8797" checksum="F437F36457E3CA86" modified="2011-05-03" version="1">MAVVSIRIPDELKAKMKEVNINWSEEIRRFIEMKIREQEKRKLLDEIDAFLEKEVPLMKKGQAVKLVRDARDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIM3</accession>
    <name>F0LIM3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiX</name>
        <name evidence="7" type="ordered locus">TERMP_00320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466595.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00320"/>
    <dbReference type="EnsemblBacteria" id="ADT83297">
        <property type="protein sequence ID" value="ADT83297"/>
        <property type="gene ID" value="TERMP_00320"/>
    </dbReference>
    <dbReference type="GeneID" id="26135661"/>
    <dbReference type="KEGG" id="tba:TERMP_00320"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.320"/>
    <dbReference type="eggNOG" id="arCOG01703">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074522_0_1_2"/>
    <dbReference type="OMA" id="GATHIQD"/>
    <dbReference type="OrthoDB" id="112962at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="79"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="177" mass="19574" checksum="EBA0F290B400456F" modified="2011-05-03" version="1">MRIVVGITGASGVIYGLRLVEVLRKLGHDVITVASETGLAVIRHEVGINFEPDYREDELFAPIASGSYRFDAVVIAPCSMKTLSAVANGYADNLITRVADVALKERRKLILLVRETPLNLIHIQNMLKVTQAGAIVMPASPGFYHNPKKLDDMINFIIGKILDILGIPYDLYKRWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIN5</accession>
    <name>F0LIN5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TldE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
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        </source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="441" mass="49797" checksum="B13F4F8C79981334" modified="2011-05-03" version="1">MFDVNELILKKAKEIGFGDVVVLSYETQRRQVRFANNEITVAKNWHYQKSAIFAEYEKRLVSTELTSLDEKTIEKTLKMLFKTAKAMEPKKDYYGIAEGPFEYKDIPETFDKKIVELDEPNEYVEIAINSALEEGAERVAGVLYTDYNKLYLTTSNNVEAFDEGTGIEISVRAFVDELSSGHGTNSVRVLKKFDPERAGRKAGEIAKLAVNPEEGEAGKYDVIFDPLAFANLLSYMSFMTSAFAVEAGFSFLVGKLGQKVASEDIVLKDVGNMPNAYGTRKFDDEGVPTQETTIIENGVLKTYLLNTSLARKYNTKTTANAGLTMPRAWNIYLEAGDYSKEELFSEIRRGIYITNVWYTRFQNYVAGDFSTIPRDGAFLIENGEIVKPIRNIRVSDNFQRILGSIAALGKELYHIHWWEVRTPVFTPYVLVKDVGITKATK</sequence>
</entry>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="ADT84522.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="267" mass="30117" checksum="32A36A78CB4A7B88" modified="2011-05-03" version="1">MPLLAIIEKELRMFFRYPLRVFSAVLVGIVFLLQFVFFGQAVLGGRYSQLLASSTGIGDYPTYALIGYVLWWLSVSPMEAYVWGIRRELQRGTFETSIAAPVRITELLLGLALSWLLMDSVLMMVVFAFGVLIFNISLTFSILLRSLPVLLLSFLAFLGFGFVFAGLVMMLKHIGPFAQIFEFAMLFFSGVFFPLNVMPKAITEFSNIFPLTHSVNAIRAIFIGKTYGEITPSVEWLLLLVIVYWLIGYALFKWAEGVIRVMGYGGY</sequence>
</entry>
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    <accession>F0LIW9</accession>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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            </authorList>
            <dbReference type="PubMed" id="21217005"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="158" mass="18242" checksum="72E8EB46146D012D" modified="2011-05-03" version="1">MVAFAYLTISPDDTQEYGQKMLPCEIPSEPLSPSYNHSFFCCPGKVGYWISASYKPPGEIIGFRAQNVPLGYNETVVFVVYKKTKDGWKVIYTENDWHAEFILPPEQNVTYALSVYVFDKDCNLIDSLYSTVFVPIQDFNAEMYLDKEVYKLEKPQSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
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        <lineage>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
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                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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    </dbReference>
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            <end position="266"/>
        </location>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="365" mass="40788" checksum="AFB9ACAE2305BCC6" modified="2011-05-03" version="1">MKLLIVGNGIAGVTLAKELSNDFDITIIDRENIPYYSKPMLSHYIAGFVDEKSLFPYSFDWYEKKSIELKLGADAKVIDRARKRVMTSEGELDYDILVLATGARAREPMVEGREHLNVLRTLEDARAIKEILEREGDAVILGGGFIALELAGNLAKAGYDVKLIHRRNTLLGLDEELSRILKKRLEDVGVEFYLNTNLVKADERGILTDRGYVEGKLKVCAFGIIPNREIAVRSGIHAGRGILIDDRFRTSAKDIYAIGDCAEYNGIICGTARASMEHAKVLANLLRGRDDKYDFEFRSSIFKLAGFSVAIIGKIGGYGRWIDENIKLFIDHREKIIGAVVLDDLRSATKLEKLIKSGAEYNDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIZ7</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466641.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00366"/>
    <dbReference type="EnsemblBacteria" id="ADT83343">
        <property type="protein sequence ID" value="ADT83343"/>
        <property type="gene ID" value="TERMP_00366"/>
    </dbReference>
    <dbReference type="GeneID" id="10040684"/>
    <dbReference type="KEGG" id="tba:TERMP_00366"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.366"/>
    <dbReference type="eggNOG" id="ENOG502N577">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335116_0_0_2"/>
    <dbReference type="OrthoDB" id="126930at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="205" mass="23302" checksum="299AB8425145DA88" modified="2011-05-03" version="1">MDEYLLIRGLVSLILILSVFYTGMVFKMLGQYMEKGKRVVFVQMIGSLLVVLASVVMGLAGNSLKSVFAIFAGIIGAFLIIHPLFRYRLIKFSKINVTQVVLVLLSSAFGHFMGLHGIAVLKTTGILSLLLLVQSLRSIKLADPLLKILLDVSLWLLVVYAWLYHLAIRYIGSCNYYLIYLIYFTALLLWFFSAVITYEHLRRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ04</accession>
    <name>F0LJ04_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L44e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl44e</name>
        <name evidence="4" type="ordered locus">TERMP_00373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466648.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00373"/>
    <dbReference type="EnsemblBacteria" id="ADT83350">
        <property type="protein sequence ID" value="ADT83350"/>
        <property type="gene ID" value="TERMP_00373"/>
    </dbReference>
    <dbReference type="GeneID" id="26135717"/>
    <dbReference type="KEGG" id="tba:TERMP_00373"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.373"/>
    <dbReference type="eggNOG" id="arCOG04109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114645_3_0_2"/>
    <dbReference type="OMA" id="CKKHTIH"/>
    <dbReference type="OrthoDB" id="106603at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01476">
        <property type="entry name" value="Ribosomal_L44e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_L44e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="PTHR10369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="94" mass="11228" checksum="2FB511468EB25586" modified="2011-05-03" version="1">MKYPKQIRTYCPFCKKHTIHKVEKVKKRPRSELSAGQRRFRRILKGYKGFPRPKPEGREKPVKKLDLRFRCTVCGKAHTRGQGFRVKKFELVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ33</accession>
    <name>F0LJ33_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MinD-like septum site-determining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466677.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00402"/>
    <dbReference type="EnsemblBacteria" id="ADT83379">
        <property type="protein sequence ID" value="ADT83379"/>
        <property type="gene ID" value="TERMP_00402"/>
    </dbReference>
    <dbReference type="GeneID" id="26135743"/>
    <dbReference type="KEGG" id="tba:TERMP_00402"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.402"/>
    <dbReference type="eggNOG" id="arCOG00589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_3_2"/>
    <dbReference type="OMA" id="DPEWAIY"/>
    <dbReference type="OrthoDB" id="53991at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="250" mass="27961" checksum="1B1C5CE676BE0D6E" modified="2011-05-03" version="1">MAVVIVTGRGGAGKTTTTANLSTYFAQREYRVLAIDGDLYLPNLGFHFGLENVKYTVHSILKNPNLDPEWAIYKHSHTGVYVMPGSTNLQDVLGISARRLRDIVDQMRYKFGLVFVDSPTGIPFDTLPTFEVANYQIIVVEIERSPIYSFEIMVENEVEKLKALGDEYGLKVGVILNKVRESQDVVDKIIETVEDDIGVPVLGVIPFDEDVPESVNVGIPILAYKPRSDASLAFYESGQLVEEWIFEKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ60</accession>
    <name>F0LJ60_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamin ABC transporter ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01607</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01607"/>
    <dbReference type="EnsemblBacteria" id="ADT84582">
        <property type="protein sequence ID" value="ADT84582"/>
        <property type="gene ID" value="TERMP_01607"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01607"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1607"/>
    <dbReference type="eggNOG" id="arCOG00177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OMA" id="IHVMRFN"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="332" mass="37927" checksum="15AE26523A9801F2" modified="2011-05-03" version="1">MSVELRGILKILGDFRLEIERLKAKEGEFLTLLGPSGCGKTTTLRIIAGFEKPDRGEVLFNGRIMNEIPPYERNIGIVFQDYALFPHMTVFKNIAFGLELRKLPREEIEKRVRQAIKLVGLEGFENRYPEQLSGGQQQRVALARALVIEPKVLLLDEPLSNLDAKIRERLRGEIKRIQKELGITTIYVTHDQEEAMAISDRIAVMNDGRIEQVGKPLELYYHPKTEFVAKFLGLSNIIELEAENGKACLGKLCFNVGKDGKVRIFFRPESVYITEGDFAEIVSYELLPGRIRLRFSIEDKEIIAERFLDELPFNVENMPKRVGVYVKSFALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ66</accession>
    <name>F0LJ66_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cob(I)alamin adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467886.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01613"/>
    <dbReference type="EnsemblBacteria" id="ADT84588">
        <property type="protein sequence ID" value="ADT84588"/>
        <property type="gene ID" value="TERMP_01613"/>
    </dbReference>
    <dbReference type="GeneID" id="10041929"/>
    <dbReference type="KEGG" id="tba:TERMP_01613"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1613"/>
    <dbReference type="eggNOG" id="arCOG04678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088595_2_0_2"/>
    <dbReference type="OMA" id="HAMGEGF"/>
    <dbReference type="OrthoDB" id="80347at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00561">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00708">
        <property type="entry name" value="cobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="177" mass="19837" checksum="80488E600C4E898C" modified="2011-05-03" version="1">MSESWKKKLGLVHIYTGNGKGKTTAALGLALRMLGNGGRVIIIQFMKAPKVYGEYFMAEKCGYVIESYGLPKFVHGEPDEDDVQAAKRALERAKEVVKSGEWDLVVLDEICVALGFGMLDVEEVKELVKSKAPNTELVLTGRYCPEELFELADYVTEMREIKHPYQKGITARRGVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJA8</accession>
    <name>F0LJA8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Maltose transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467928.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01655"/>
    <dbReference type="EnsemblBacteria" id="ADT84630">
        <property type="protein sequence ID" value="ADT84630"/>
        <property type="gene ID" value="TERMP_01655"/>
    </dbReference>
    <dbReference type="GeneID" id="10041971"/>
    <dbReference type="KEGG" id="tba:TERMP_01655"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1654"/>
    <dbReference type="eggNOG" id="arCOG00157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_2"/>
    <dbReference type="OMA" id="WLAYPFM"/>
    <dbReference type="OrthoDB" id="42276at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="297" mass="33904" checksum="EA4E6BF9538340BF" modified="2011-05-03" version="1">MKKTTVVALFLILPGIIAFLTFNLWPIVYSIYIAFTNAQLGNFPIESTKQLQFVGLENFKWALSDEKFRRAFLWTWFFVLTSVTLKVSSGIFLSILYNNKYVRGRLFYRSLLIIPWALPLLFSITVWRFMFDPVFGPINIVLKSLGISNPPNWINDPWWGFIALNIIEVWLAYPFMMTVITAALQSVPDTLIEAAIIDGATYWQRLRHVVIPIVSKPIAFATILTSAASFQYFMVPYLYNAGLFEDKFLLLYGFRKAFGASPHYGRAAAIMVIATLVLAVYMYINVKITKLQEGAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJC8</accession>
    <name>F0LJC8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00417"/>
    <dbReference type="EnsemblBacteria" id="ADT83394">
        <property type="protein sequence ID" value="ADT83394"/>
        <property type="gene ID" value="TERMP_00417"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00417"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.417"/>
    <dbReference type="eggNOG" id="arCOG05754">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152354_0_0_2"/>
    <dbReference type="OMA" id="SINGRHR"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="73" mass="8256" checksum="3A4C4D920D68DAE3" modified="2011-05-03" version="1">MLILRSINGKHRSLNALLEEISKDTKKPISTLKLNARILKELGLIDYGEKNNPKPVELTKHGKLVLKILEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJD3</accession>
    <name>F0LJD3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="1">3-dehydroquinase</shortName>
            <ecNumber evidence="1">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Type I DHQase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Type I dehydroquinase</fullName>
            <shortName evidence="1">DHQ1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroD</name>
        <name evidence="2" type="ordered locus">TERMP_00422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466697.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00422"/>
    <dbReference type="EnsemblBacteria" id="ADT83399">
        <property type="protein sequence ID" value="ADT83399"/>
        <property type="gene ID" value="TERMP_00422"/>
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    <dbReference type="GeneID" id="10040740"/>
    <dbReference type="KEGG" id="tba:TERMP_00422"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.422"/>
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    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:chorismate biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AroD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <property type="entry name" value="DHquinase_I"/>
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        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="3-dehydroquinate binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="216" mass="24566" checksum="8E32D2D9C043590A" modified="2011-05-03" version="1">MIAGTIKAKGIDEVIKIIERGEADLYELRVDAMESFEGIEKLKPFAGKLIITVRSKEEGGFREIRDEERLKLFKEFLEINPAFVDVEFKSKIAEDVIRLAREKKVRVIISYHDFEKTPSFEELKALLEEMKKLKADVIKVVTFAKHHIDNVRIVRLYEYEKNLIAFCMGEKGKISRALSLILSPFTYASLDEAAAPGQLSAEDMKLLLALIGDGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJK9</accession>
    <name>F0LJK9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467949.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01676"/>
    <dbReference type="EnsemblBacteria" id="ADT84651">
        <property type="protein sequence ID" value="ADT84651"/>
        <property type="gene ID" value="TERMP_01676"/>
    </dbReference>
    <dbReference type="GeneID" id="10041992"/>
    <dbReference type="KEGG" id="tba:TERMP_01676"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1675"/>
    <dbReference type="eggNOG" id="arCOG05858">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2420210_0_0_2"/>
    <dbReference type="OMA" id="MMEMDEN"/>
    <dbReference type="OrthoDB" id="124700at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="88" mass="9935" checksum="4AA59D9935CC7029" modified="2011-05-03" version="1">MDENRVLLNYYLFTVPHITVLAGAVLGLLLLLKVDIKKALGIFAVFYGSMLTILAFMVRDHFSRLVLYKLSLIIFFGFTLLGIVLLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJL4</accession>
    <name>F0LJL4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nadE</name>
        <name evidence="9" type="ordered locus">TERMP_01681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467954.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01681"/>
    <dbReference type="EnsemblBacteria" id="ADT84656">
        <property type="protein sequence ID" value="ADT84656"/>
        <property type="gene ID" value="TERMP_01681"/>
    </dbReference>
    <dbReference type="GeneID" id="10041997"/>
    <dbReference type="KEGG" id="tba:TERMP_01681"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1680"/>
    <dbReference type="eggNOG" id="arCOG00069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059327_1_1_2"/>
    <dbReference type="OMA" id="MAFLYDY"/>
    <dbReference type="OrthoDB" id="89944at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="244"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="254" mass="28642" checksum="E70A86CAECCBD2D2" modified="2011-05-03" version="1">MRTLNYEEVIEKIVYFIKEKVDEANASGVVIGVSGGVDSATTAFLAVKALGKDKVLGLIMPYYENQDVKDAKLVCETLGINYKIINIKPIVDAFEKSLDFEPDKITKGNVMVRTRMTLLYAHANQYNLLVLGTSNKSELLTGYYTKWGDGASDYAPLINLYKTEVWEIAKRLGVPERIIKKKPTAGLWIGQTDEGELGISYKLLDEILYRLVDLKMPKEKIAEELNIPIKKIEYVENLIKKSEHKRKLPAGPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJM4</accession>
    <name>F0LJM4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01691"/>
    <dbReference type="EnsemblBacteria" id="ADT84666">
        <property type="protein sequence ID" value="ADT84666"/>
        <property type="gene ID" value="TERMP_01691"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01691"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1690"/>
    <dbReference type="eggNOG" id="arCOG07094">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111888_0_0_2"/>
    <dbReference type="OMA" id="FTITWIV"/>
    <dbReference type="OrthoDB" id="83618at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="217" mass="24605" checksum="B855315FC4ADA667" modified="2011-05-03" version="1">MDIFQVLAYVLIIPFVLLNVMISMMRFFISAGSKLMTKIFRIQIPKNEKREYEILFTITWIVAGIYALKSFKNTNILLGILIFLTFRNGAAISKKLIYGIHDANLIKENAEDKKILGLINRAVGLGILSEILFLFIWALSYRAITIGMNALLRLGLNELVLYLWIAGVVFGAVFGMFISHNNKGILLQNEVMLVLLFAGKKGFRTFMSLKQGTKQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJS1</accession>
    <name>F0LJS1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468010.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01738"/>
    <dbReference type="EnsemblBacteria" id="ADT84713">
        <property type="protein sequence ID" value="ADT84713"/>
        <property type="gene ID" value="TERMP_01738"/>
    </dbReference>
    <dbReference type="GeneID" id="10042054"/>
    <dbReference type="KEGG" id="tba:TERMP_01738"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1737"/>
    <dbReference type="eggNOG" id="arCOG02959">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035477_0_0_2"/>
    <dbReference type="OMA" id="CHPKPGA"/>
    <dbReference type="OrthoDB" id="43374at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="226"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="560" mass="63711" checksum="67DCE4C7312855F4" modified="2011-05-03" version="1">MKEFLEESRINVDEILRHIMNISQFHRIQGSKEIVDAAKYILEELKKAGIDAQLLKDVYDGETWHLTLKSPIGWDLIYGEIEIFGKKFTTEEIPLVVMAHSPSGEAEGEMVYIEREDDWEKAEGKIVLVGKKWKDNYKKANKSGAIGFVAYRKGTGKAFPYMGLFLSRKDLEWAKIPAVAVSEEIANKIISKLKKGESVKAKIRVQTEIRDKQILPMVYAKIGKPPYILFTAHICHPKPGANDNASGSAMLIELAKALKEKHSEDFRFGFAFLWIPEYHGTQAFIEKFAELENYYAVINLDMVGGSEDRSNSTIMIVRTPLSRFSIVSGLLEYYLNLANSQGESFGGEGMPKLKVKSYSYQMGSDHDIFNFFGVPGVMPITWPDKFYHSSEDSIEKISKDSLEVIGKAVLATALALAKAEKEKLQRFARGYAMKYLGELGMDREIEVAEKLVMRGLARDGKFLGIDIGHDLEFKAWIKWKRKGLVSVRTIREFEEKAAKELEEFMEDKKFSIHLHELLMLGEILPEEEAFKALEEEFGKIDREKLNKALEILKKLGFIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJU6</accession>
    <name>F0LJU6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hydroxyethylthiazole kinase</fullName>
            <ecNumber evidence="9">2.7.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">4-methyl-5-beta-hydroxyethylthiazole kinase</fullName>
            <shortName evidence="9">TH kinase</shortName>
            <shortName evidence="9">Thz kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiM</name>
        <name evidence="10" type="ordered locus">TERMP_00506</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Thz kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.50" evidence="9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466781.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00506"/>
    <dbReference type="EnsemblBacteria" id="ADT83483">
        <property type="protein sequence ID" value="ADT83483"/>
        <property type="gene ID" value="TERMP_00506"/>
    </dbReference>
    <dbReference type="GeneID" id="10040824"/>
    <dbReference type="KEGG" id="tba:TERMP_00506"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.506"/>
    <dbReference type="eggNOG" id="arCOG00019">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019943_0_0_2"/>
    <dbReference type="OMA" id="KRPLVHN"/>
    <dbReference type="OrthoDB" id="70640at2157"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000513">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00694">
        <property type="entry name" value="thiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="266" mass="28882" checksum="152C553366984D76" modified="2011-05-03" version="1">MEWIAKALERVRKRKPLVQNITNFVVMNTTANALLALGASPVMAHARDELEDMLRIADSLVVNIGTLDEHWIPSMEKAVKIASELKKPTVLDPVGAGATKLRTETALRLLEIGDITILRGNFGEIAALLGEHGRTRGVDSATYEEDKAKELALTAAREFNTVVAVTGPVDYVSDGKGVYAVYNGNEMLGRVTGTGCMVTAITGAFAAVEEPLKAAVSALAIFGIAAEKACEEAKYPGSFHVKLYDWLYRIDEELIIERAKVRKVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJW5</accession>
    <name>F0LJW5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466800.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00525"/>
    <dbReference type="EnsemblBacteria" id="ADT83502">
        <property type="protein sequence ID" value="ADT83502"/>
        <property type="gene ID" value="TERMP_00525"/>
    </dbReference>
    <dbReference type="GeneID" id="10040843"/>
    <dbReference type="KEGG" id="tba:TERMP_00525"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.525"/>
    <dbReference type="eggNOG" id="arCOG05750">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1399792_0_0_2"/>
    <dbReference type="OMA" id="YYRGLLC"/>
    <dbReference type="OrthoDB" id="72599at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="195" mass="22571" checksum="1438943C7D1AA9F7" modified="2011-05-03" version="1">MIAFLLYLVSLIFIILNWHLGKNIYEWAFYDILFYVFLPLTAAYLLGFKPNELGFKIGKREGYIWAFVLFSATLPVSVYASRIESFRSFYPIFSYSSWGDFIFKELLIGAIMFAHEAFYRGILLFPLAEKNEWLGILLQNIPYTLIHIGKPTLEIPYSFIAGIIFAKMDLKSESFLPSFLLHWIGAVAFDVLCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK06</accession>
    <name>F0LK06_THEBM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466841.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00566"/>
    <dbReference type="EnsemblBacteria" id="ADT83543">
        <property type="protein sequence ID" value="ADT83543"/>
        <property type="gene ID" value="TERMP_00566"/>
    </dbReference>
    <dbReference type="GeneID" id="26135892"/>
    <dbReference type="KEGG" id="tba:TERMP_00566"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.567"/>
    <dbReference type="eggNOG" id="arCOG10109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1521921_0_0_2"/>
    <dbReference type="OMA" id="WIVESTS"/>
    <dbReference type="OrthoDB" id="94643at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="174" mass="18962" checksum="1F2921812E3660AE" modified="2011-05-03" version="1">MKKEIMSILGFGGLGITLSFFLIVMVYPSYTAMEKLMPLYLGGLILGGIFGMVKGNINASGYAFILGFLITTVLHLLWISFPFKVSYAFAFLALVVFVMWIVESTSTLDIAVTPFAYFGGFILAAILFRNVEMYKIEGSVMSIVLVGVAGAGISLLMSMFKAFVETAQTAKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK17</accession>
    <name>F0LK17_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468026.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01754"/>
    <dbReference type="EnsemblBacteria" id="ADT84729">
        <property type="protein sequence ID" value="ADT84729"/>
        <property type="gene ID" value="TERMP_01754"/>
    </dbReference>
    <dbReference type="GeneID" id="10042070"/>
    <dbReference type="KEGG" id="tba:TERMP_01754"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1753"/>
    <dbReference type="eggNOG" id="arCOG01872">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1393631_0_0_2"/>
    <dbReference type="OMA" id="MPFLVNY"/>
    <dbReference type="OrthoDB" id="78708at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="201" mass="23012" checksum="862D32FF2F80D15C" modified="2011-05-03" version="1">MRAYILAFPEKRWESYLTPLNGGSLVKIVEQRLRMTKRIDKVYTIIRKGQLKRFSLHVSNPVGVEAKNKIEALYKALPASGELLLVEGNMPLIMPFLVNYLSTLFLDSDSEALIPSWSDGRLEVTHAFYDAKALKSALETCLAENEKKLSCIKEYLDYETVSIEELAKRNPKITLSFFKVKSSFDLRFAEETLKKIERGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK33</accession>
    <name>F0LK33_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 10">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">upp</name>
        <name evidence="11" type="ordered locus">TERMP_01770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 10"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468042.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01770"/>
    <dbReference type="EnsemblBacteria" id="ADT84745">
        <property type="protein sequence ID" value="ADT84745"/>
        <property type="gene ID" value="TERMP_01770"/>
    </dbReference>
    <dbReference type="GeneID" id="10042086"/>
    <dbReference type="KEGG" id="tba:TERMP_01770"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1769"/>
    <dbReference type="eggNOG" id="arCOG04128">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_0_2"/>
    <dbReference type="OMA" id="TYATRMP"/>
    <dbReference type="OrthoDB" id="85528at2157"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_A">
        <property type="entry name" value="Upp_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034331">
        <property type="entry name" value="Upp_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="10">
        <location>
            <begin position="140"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="10">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT84745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="225" mass="25084" checksum="B867DD9B54F92869" modified="2011-05-03" version="1">MIADKRWKGVYSFEDSPFLMEILTELRNKHTGAIEFRKGLVKLGRYMGYELTKTMDFEKVEIETPLEKTEGIIAKDRKNVVIVTVLRAAIPLMEGLIKVFEHARVGIVSASRGKAPKFEIEMNYIKIPEIKPEDTVIIADPMIATGSTLLKVIEEVKKYGTPKRLIVLGVLAAPEGISRIKGAYPEVEVFVTKIDRELNDHGYILPGLGDAGDRAFGAPIKTAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKB3</accession>
    <name>F0LKB3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00594"/>
    <dbReference type="EnsemblBacteria" id="ADT83571">
        <property type="protein sequence ID" value="ADT83571"/>
        <property type="gene ID" value="TERMP_00594"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00594"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.595"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_15_2"/>
    <dbReference type="OMA" id="WGVLAQV"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="64" mass="6654" checksum="E14D418DB95C716C" modified="2011-05-03" version="1">MYAIEIENLTKSYGNSKAVDGLSLEVHKGDVFGFLGPNGAGKTTTILSMLGLIIPDSGTVKILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKD3</accession>
    <name>F0LKD3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxoglutarate oxidoreductase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of one alpha, one beta, one delta and one gamma chain.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466889.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00614"/>
    <dbReference type="EnsemblBacteria" id="ADT83591">
        <property type="protein sequence ID" value="ADT83591"/>
        <property type="gene ID" value="TERMP_00614"/>
    </dbReference>
    <dbReference type="GeneID" id="10040932"/>
    <dbReference type="KEGG" id="tba:TERMP_00614"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.616"/>
    <dbReference type="eggNOG" id="arCOG01607">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_0_1_2"/>
    <dbReference type="OMA" id="DFIQGDE"/>
    <dbReference type="OrthoDB" id="34838at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="3">
        <location>
            <begin position="282"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="387" mass="42662" checksum="050544A9849648E1" modified="2011-05-03" version="1">MKYPFPVGKSDFIQGDEAIARAAILAGCRFYAGYPITPASEIFEAMALYMPLVDGVSIQMEDELASIAAIIGASWVGAKAMTATSGPGFSLMMENLGYAIMTETPIVVVDVQRSGPSTGQPTLAAQGDVMQAIWGTHGDHSLIVLTPATVQEAFDMTIRAFNLAEKYRTPVILLTDAEVGHMREKVDIPNPEDIELIYRKLPANEEEAKYPFGDIHGDLIPPMPIFGKGYRTYVTGLTHDEKGRPKTVDAEIHRKLIERIVNKIEKNKKDIIDYETFDLDDAEVAIISYGIVARSAIRAVKMLRSEGIKAGLLKLNVVWPFDFEMIEKIAEQVNAIYVPEMNLGQVYHLVKEGANGKARVELIPKIGGEVHTPQEIVKAVKRCEKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKG4</accession>
    <name>F0LKG4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466920.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00645"/>
    <dbReference type="EnsemblBacteria" id="ADT83622">
        <property type="protein sequence ID" value="ADT83622"/>
        <property type="gene ID" value="TERMP_00645"/>
    </dbReference>
    <dbReference type="GeneID" id="10040963"/>
    <dbReference type="KEGG" id="tba:TERMP_00645"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.647"/>
    <dbReference type="eggNOG" id="arCOG01075">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_20_3_2"/>
    <dbReference type="OMA" id="NRDPRGH"/>
    <dbReference type="OrthoDB" id="116493at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="174" mass="19668" checksum="65D9E2648F66DC6F" modified="2011-05-03" version="1">MDRYVLLIKAPKGYDMAPVKRDITKLILKKYPELKAEVHKCIGLTVDLVIFYKDGIVLIKRKHEPFKNHWALPGGFVEYGERVEDAAIREAKEETGLNVELIKLIGVYSDPNRDPRGHTVTIAFLAKGHGNLRGGDDAREAKVFSFDEIKSLKLAFDHGKILDDALRSLREVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKI1</accession>
    <name>F0LKI1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468111.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01840"/>
    <dbReference type="EnsemblBacteria" id="ADT84815">
        <property type="protein sequence ID" value="ADT84815"/>
        <property type="gene ID" value="TERMP_01840"/>
    </dbReference>
    <dbReference type="GeneID" id="10042156"/>
    <dbReference type="KEGG" id="tba:TERMP_01840"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1839"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_3_2"/>
    <dbReference type="OMA" id="ISYAHPH"/>
    <dbReference type="OrthoDB" id="39139at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="136"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="334" mass="37485" checksum="01D1FE29BD995B63" modified="2011-05-03" version="1">MKINVGIISYAHPHALRYGSTFASNPKVKLHAISGDGSNSDVAKREAQRFKAKFYRTYDELLKDKKIDAVYVAIETYRHKEVALRVIEEGKHLLLEKPIALTLEDADEIIKAAKKAGVKLMVPFNPRFTIPLRKAKSMIESGEIGSLEYVYAISEYVKPPIFLEGLDMSWFLDKDKAGGGGFMDTAPHGIDSLLWLTESDVEKVYADIGSKIYGFPVDDIGTAVLEFKNGVTAVLNAGWGNPKGYSYGLEMKYYILGKDGFLDVRTAYPDFTVYQDRAEKIYWERPDVESIVKYFIEAILEDKEPPITGEDARKNLEIVLAAYESSKTGKVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKI4</accession>
    <name>F0LKI4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01843"/>
    <dbReference type="EnsemblBacteria" id="ADT84818">
        <property type="protein sequence ID" value="ADT84818"/>
        <property type="gene ID" value="TERMP_01843"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01843"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1842"/>
    <dbReference type="eggNOG" id="arCOG01241">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_741069_0_0_2"/>
    <dbReference type="OMA" id="VEYIITM"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="173"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="363" mass="42600" checksum="6B73FC5200526B51" modified="2011-05-03" version="1">MCGSPAGIRTPVAGSKARRKSLYSPNEGFIGLISEEAMKMPQQTFPAIGHVFHSSGKQDYYRRLLQVQNPNQYYVITEEDINRLFLEFEAKGVTHSHKRSVEYIITMFLKEATKENHGRYIFTMKDLKEYLTLIRQSYSPSFYRKNITYLKKLFRIAGIDLAESLKAPTELNVDLTIVTVDDIKSLIQLVDSLHISNRFEDWKRDQFITAMLLMAVSGMRVSELERIPLKEIDIENRRIRLNTHQTKTRQARVVFFTSEVQELLEDYIRTHRPNVNLPLATIAQLQRPFRKKSPLRNQKLRPKHMRKFFAQEWDRRNGNATIKKMLMGHSIRYDINALHYSHHTVDELQDAYDKVFCDLRFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKI5</accession>
    <name>F0LKI5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468115.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84819">
        <property type="protein sequence ID" value="ADT84819"/>
        <property type="gene ID" value="TERMP_01844"/>
    </dbReference>
    <dbReference type="GeneID" id="10042160"/>
    <dbReference type="KEGG" id="tba:TERMP_01844"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1843"/>
    <dbReference type="eggNOG" id="arCOG01057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_668379_0_0_2"/>
    <dbReference type="OMA" id="MENDFEL"/>
    <dbReference type="OrthoDB" id="62993at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="361" mass="42146" checksum="86381C855EE0CA0D" modified="2011-05-03" version="1">MASAELKSKILEYLEQVGIATRNEIMKATNKSGKTLTIALEELVKAGAVELVSENPLTYRIVRTNVVIVDLNDIKSYYDLKFEIFRKLRSFGWRVSTHEIVAIALMYAKFTKFRILVFGSQGAGKTSLIQAVFGKIGEPIVVQDLHLKNLYDVVRSVKERTKVIEQQYRHAWGKETLERFDRYKVVPISRIAPSDLLFRFVPVRITQPQRPGIGLFKPVRFEFTNVPVIEDIPDDVFLRLEEALKHVRYFTIDPTWVRERVMKLKMDEMVNYTDNVSAEFYRINVRYDAKMENDFELVNWKILHEYDSLYLDMASNLQLLLNALEVLKFNYSWLGDEEKAVEQTVDFMRDVFKTFTIVKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKJ5</accession>
    <name>F0LKJ5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468125.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01854"/>
    <dbReference type="EnsemblBacteria" id="ADT84829">
        <property type="protein sequence ID" value="ADT84829"/>
        <property type="gene ID" value="TERMP_01854"/>
    </dbReference>
    <dbReference type="GeneID" id="10042170"/>
    <dbReference type="KEGG" id="tba:TERMP_01854"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1853"/>
    <dbReference type="HOGENOM" id="CLU_2032970_0_0_2"/>
    <dbReference type="OrthoDB" id="135631at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="121" mass="14190" checksum="3CBB918BC3AABE95" modified="2011-05-03" version="1">MVLENDPIKRRLEILEFFIEYPKKISEFHKRFGSEIDVQLLEEMLNNELLATDYPLIVGIGRTSRDELKNPSMDYEIRITEKGLNFYYQDFINKKALRYSKIAVGISLGSLLIQVLPKLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKN0</accession>
    <name>F0LKN0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fumarylacetoacetate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468160.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01889"/>
    <dbReference type="EnsemblBacteria" id="ADT84864">
        <property type="protein sequence ID" value="ADT84864"/>
        <property type="gene ID" value="TERMP_01889"/>
    </dbReference>
    <dbReference type="GeneID" id="10042205"/>
    <dbReference type="KEGG" id="tba:TERMP_01889"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1888"/>
    <dbReference type="eggNOG" id="arCOG00235">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_5_0_2"/>
    <dbReference type="OMA" id="YALSIDM"/>
    <dbReference type="OrthoDB" id="72644at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="225" mass="25133" checksum="42EEA524B4C58FC7" modified="2011-05-03" version="1">MIRLPFRDGFYEVNPSKIICLGRNYAEHAKELGHEVPKEPVIFLKPPSALIGPNQTIILPKKSREVHHEVELAVIIGKRGKNIPREKAMDYVLGYTILLDITARDLQWEAKRKGLPWTVAKGFDTFAPIGPRIVPKEELDPSDLEIGLKVNGEVRQLSRTGKMIFKIPEIIEYISSIMTLEKGDIIATGTPEGVGPLRHGDTVEAWIEGIGVLKENVLAERSILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKQ7</accession>
    <name>F0LKQ7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466934.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00659"/>
    <dbReference type="EnsemblBacteria" id="ADT83636">
        <property type="protein sequence ID" value="ADT83636"/>
        <property type="gene ID" value="TERMP_00659"/>
    </dbReference>
    <dbReference type="GeneID" id="10040977"/>
    <dbReference type="KEGG" id="tba:TERMP_00659"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.661"/>
    <dbReference type="eggNOG" id="arCOG03772">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1754804_0_0_2"/>
    <dbReference type="OMA" id="FAAFSKM"/>
    <dbReference type="OrthoDB" id="107075at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017140">
        <property type="entry name" value="UCP037214"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10015">
        <property type="entry name" value="DUF2258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="152" mass="17644" checksum="4A8F44D2217C7F2C" modified="2011-05-03" version="1">MPRLLTGFVRAAGYANKVRKVLFAITRGKVNPEEVVRAAAELNQYLFNKFQEIGVKKEDVVRIEAEFDIKDGKIEWNFDSLKIEIYKKEEEEKLAEAMREVEESEKALELVVEELSKLSEKLRSLSDEISQLVQKIKQEHTALKLEFEKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKQ8</accession>
    <name>F0LKQ8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Adenylate kinase</fullName>
            <shortName evidence="5">AK</shortName>
            <ecNumber evidence="5 7">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adk</name>
        <name evidence="9" type="ordered locus">TERMP_00660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="5 7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466935.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00660"/>
    <dbReference type="EnsemblBacteria" id="ADT83637">
        <property type="protein sequence ID" value="ADT83637"/>
        <property type="gene ID" value="TERMP_00660"/>
    </dbReference>
    <dbReference type="GeneID" id="10040978"/>
    <dbReference type="KEGG" id="tba:TERMP_00660"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.662"/>
    <dbReference type="eggNOG" id="arCOG01046">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_2"/>
    <dbReference type="OMA" id="FHNRMRV"/>
    <dbReference type="OrthoDB" id="55175at2157"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADK_lid" evidence="8">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="5">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="5">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="83"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="224" mass="25965" checksum="E9AED16DF47A7792" modified="2011-05-03" version="1">MNILIFGPPGSGKSTHSRKIIEKYNLVYISSGDIIRGEINKGTTLGREMEKYLSQGDLIPDIVVNTLVLSRLRRTRNNFIIDGYPRTAEQVLALENYLYDHGIRLDVAIDIFISKEESIERISGRRICSKCGAVYHVHYKPPKIPNTCDICGGKIIQRPDDKPEIVSKRYDVYIKNMRPIIKFYRKQGVYVQINGHGGIEEVWERIRPLLDYIYNKEKKRKEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKS9</accession>
    <name>F0LKS9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466956.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00681"/>
    <dbReference type="EnsemblBacteria" id="ADT83658">
        <property type="protein sequence ID" value="ADT83658"/>
        <property type="gene ID" value="TERMP_00681"/>
    </dbReference>
    <dbReference type="GeneID" id="10040999"/>
    <dbReference type="KEGG" id="tba:TERMP_00681"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.682"/>
    <dbReference type="eggNOG" id="arCOG01705">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098523_0_0_2"/>
    <dbReference type="OMA" id="CCASQAL"/>
    <dbReference type="OrthoDB" id="72619at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="176" mass="19939" checksum="78EB5D2ACF252958" modified="2011-05-03" version="1">MRIAWGISGAGHLLKESIEILEKLKDKHEIKIFLSRAGEEVAKMYKLFDRLEKFPLVKESKQGFSFPSCGAFNLERFDVFIISPATSNTVAKIRLGIADSLLSCCASQALKSRVPLILVPTDSKPVVETKAPNGQIFKIYVRKVDLEHLRALKREGVIILEHPYEVEKALERFLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKV5</accession>
    <name>F0LKV5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ordered locus">TERMP_00707</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466982.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00707"/>
    <dbReference type="MEROPS" id="C26.964"/>
    <dbReference type="EnsemblBacteria" id="ADT83684">
        <property type="protein sequence ID" value="ADT83684"/>
        <property type="gene ID" value="TERMP_00707"/>
    </dbReference>
    <dbReference type="GeneID" id="10041025"/>
    <dbReference type="KEGG" id="tba:TERMP_00707"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.708"/>
    <dbReference type="eggNOG" id="arCOG00063">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_2"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="14061at2157"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="300"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="379"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="186"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT83684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="533" mass="60022" checksum="5EFC93328F94D014" modified="2011-05-03" version="1">MTKFIFVTGGVVSGLGKGITSASIGLLMKARGFKTTNIKIDPYLNYDAGTMNPYQHGEVFVLDDGGEVDLDLGNYERFLDTNLTFDHNITTGKVYSAVIEKERRGDYLGATVQVIPHITNEIKERIRRIARDHDVVIIEIGGTVGDIESMPFLEAARQMQLEEGRENVAFVHVTYVPKLKVVGEQKTKPTQHSVKELRSLGIQPDAIVARSEDPLEDSARKKISLFTNVPEEAVISAYDVEDTYEVPLLLEREGLGKYLVKRLGLENREPELKAWEKMVAKYKSLKDSIEIAIVGKYVKLKDSYLSIIEALKHSSVANEVKVKIRWIEAEDVEKYGVGLLEGVDGIIVPGGFGARGTEGKMMAIRYARENDIPFLGICFGFQLTVVEFARNVLGLKGAHSTEIDPNTPYPVVDLLPEQRGIDKLGGTMRLGAYPVRIKPNTLAHRVYGTELVYERHRHRWEVNPDYIEEFERAGLIFSGISGDDKRRMEILELPEHRYFIATQFHPEFKSRPMKPAPVFRELVKAAKEKKFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKV6</accession>
    <name>F0LKV6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_00708</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466983.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00708"/>
    <dbReference type="EnsemblBacteria" id="ADT83685">
        <property type="protein sequence ID" value="ADT83685"/>
        <property type="gene ID" value="TERMP_00708"/>
    </dbReference>
    <dbReference type="GeneID" id="10041026"/>
    <dbReference type="KEGG" id="tba:TERMP_00708"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.710"/>
    <dbReference type="eggNOG" id="arCOG02405">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_732847_0_0_2"/>
    <dbReference type="OMA" id="TMVIFKV"/>
    <dbReference type="OrthoDB" id="72052at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13098">
        <property type="entry name" value="Thioredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
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    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="10"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="430" mass="47206" checksum="CA9109CC050354D1" modified="2011-05-03" version="1">MKRISILIFLLLIMPALVDTLPTVKYGAVNFIPVATENELKEVINTNEGQYIFVYYYSPTCPACKYMRDNVFADPSIVRLLSERAVPIIVDVYKGREVTSLRYKVYSKVLVIQPDNSGYYTPKSSGEEVTVSVPGTPTMVVFKVENGEKILRGVAVGALNKQGFEFFIEQTTEKKANVKTPNPKASTTTAAQTQNESRLTFAVLLTIFSAGILSVFSPCVLPLVVSGFALILAKRNLGLIILGMIAAFSLIGGAAGALGSYISQITALLYLIGGTGFIVLGTIMVSEKANLYFTSKIGRIQRFAEKNHKFRGKFADFLFGASLGATWIGCIAPYVGFAILTAALSRNFTKGVIVMFIYALGVGLTFYLVLSSKDLAQWINKRFLSNKLTLRSSDRKLEKAVGILMILIGMLMLTELTPLKLWSHLFEKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKY3</accession>
    <name>F0LKY3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT84890">
        <property type="protein sequence ID" value="ADT84890"/>
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    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01915"/>
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    <dbReference type="eggNOG" id="arCOG07520">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3113260_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="50" mass="6033" checksum="1273080F2B8E82FC" modified="2011-05-03" version="1">MYFILELLANGWSIEEILENYPQLKKEDIYEAIRYASMILKEEEYIEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKY8</accession>
    <name>F0LKY8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01920"/>
    <dbReference type="EnsemblBacteria" id="ADT84895">
        <property type="protein sequence ID" value="ADT84895"/>
        <property type="gene ID" value="TERMP_01920"/>
    </dbReference>
    <dbReference type="GeneID" id="10042236"/>
    <dbReference type="KEGG" id="tba:TERMP_01920"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1919"/>
    <dbReference type="eggNOG" id="arCOG00732">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142189_1_1_2"/>
    <dbReference type="OMA" id="KARLGIM"/>
    <dbReference type="OrthoDB" id="121646at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027395">
        <property type="entry name" value="WH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13601">
        <property type="entry name" value="HTH_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_34" evidence="1">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="99" mass="11146" checksum="7CB14EB151516C02" modified="2011-05-03" version="1">MDTIRQLVKNHVLGNPIRLGIMLYLLPRGRVLFKELQKVLDVTPGNLDSHLKTLEKAGYVKLTKVFADRPRTAVEITDKGAEETGKYLRTLKSLLTGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL23</accession>
    <name>F0LL23_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 13">DNA ligase</fullName>
            <ecNumber evidence="13">6.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polydeoxyribonucleotide synthase [ATP/NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lig</name>
        <name evidence="16" type="ordered locus">TERMP_01956</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.6" evidence="13"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468226.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="SMR" id="F0LL23"/>
    <dbReference type="STRING" id="391623.TERMP_01956"/>
    <dbReference type="EnsemblBacteria" id="ADT84930">
        <property type="protein sequence ID" value="ADT84930"/>
        <property type="gene ID" value="TERMP_01956"/>
    </dbReference>
    <dbReference type="GeneID" id="10042271"/>
    <dbReference type="KEGG" id="tba:TERMP_01956"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1954"/>
    <dbReference type="eggNOG" id="arCOG01347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_6_0_2"/>
    <dbReference type="OMA" id="WLFEESY"/>
    <dbReference type="OrthoDB" id="52275at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="328"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="13">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADT84930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="561" mass="63886" checksum="1F16B32ED6C1A660" modified="2011-05-03" version="1">MLYKELAELYRRLEKTTLKTLKTRFVADFLKKVEDEELLEIVPYLILGKVFPDWDERELGVGEKLLIKAVAMATGINAEWIENSVKDTGDLGESVALALQKRKQRSFFGQPLTIKRVYKTLVKVAETTGEGSQDRKLKYLANLFMDAEPIEGKYLARTILGTMRTGVAEGLLRDAIAEAFRVKPELVERAYMLTSDFGFVTKIAKLEGNEGLSKVTIQIGKPIKPMLAQMAANVREALVEMGGEAEFEIKYDGARVQVHKDGDKVIIYSRRLENVTKSIPEVVERIKKSIKPEKAIVEGELVAVGEGGRPRPFQYVLRRFRRKYNIQEMIEKIPLELNLFDVLYVDGENLIDTPFIERRKKLESIVEVNQWIKVAENLITKSPEEAEEFYHKALDMGHEGLMAKRLDSVYEPGNRGKKWLKIKPTMENLDLVIIGAEWGEGRRAHVLSSFLLGAYDPGTGTFVPVGKVGSGFTDEDLVEFTKMLKPLIKKEKGKFVEIEPKVVIEVTYQEIQKSPKYESGFALRFPRYVALREDKSPEDADTLERIAQLYELQERMKAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL24</accession>
    <name>F0LL24_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pantoate kinase</fullName>
            <shortName evidence="1">PoK</shortName>
            <ecNumber evidence="1">2.7.1.169</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28246"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. PoK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.169" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468227.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01957"/>
    <dbReference type="EnsemblBacteria" id="ADT84931">
        <property type="protein sequence ID" value="ADT84931"/>
        <property type="gene ID" value="TERMP_01957"/>
    </dbReference>
    <dbReference type="GeneID" id="10042272"/>
    <dbReference type="KEGG" id="tba:TERMP_01957"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1955"/>
    <dbReference type="eggNOG" id="arCOG04263">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081191_0_0_2"/>
    <dbReference type="OMA" id="MLGETVF"/>
    <dbReference type="OrthoDB" id="104702at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02223">
        <property type="entry name" value="Pantoate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012043">
        <property type="entry name" value="PoK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42282">
        <property type="entry name" value="PTHR42282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016896">
        <property type="entry name" value="GHMP_arc_MJ0969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="2">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="303" mass="33461" checksum="350FD72FCE3D84B0" modified="2011-05-03" version="1">MLIRAFIPAHITAFFVPKFNENPLLAGSLGAGINLTKGTNVFVSVEVESVLEKHVHIAFNGEPVKRKDAIISYSVAEEVTPQEFKGEVEIWQYFDFPNGYGFGNSAGGALGTALALGYYFKNKTFLQAAQIAHKHEVLNKGGLGDVIAQIHGGIEIRIKAGAPGIGIVDNIFSEEYKVLAIPLGRLSTKEVLDSDIIRTIEKEGQKALRRLLKNPTPENLMHLARDFAENTGLLNGELLEIAKEIDKLIKLPSSMIMLGKSLFALLREEELPKVQERLRDLGIDSYHICGIYNERPKVGRWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL71</accession>
    <name>F0LL71_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467020.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00745"/>
    <dbReference type="EnsemblBacteria" id="ADT83722">
        <property type="protein sequence ID" value="ADT83722"/>
        <property type="gene ID" value="TERMP_00745"/>
    </dbReference>
    <dbReference type="GeneID" id="10041063"/>
    <dbReference type="KEGG" id="tba:TERMP_00745"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.747"/>
    <dbReference type="eggNOG" id="arCOG02292">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_3_2"/>
    <dbReference type="OMA" id="DHVEFWK"/>
    <dbReference type="OrthoDB" id="68989at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="224" mass="25986" checksum="6454E3B8C1108411" modified="2011-05-03" version="1">MIKALIFDVDETLVYYENYDAKEWFSKYLEPAFQQHGINIDFETYRKMVKGILPRSYVERFGIDHVEFWKLVDNVNLRYRKVLAKEGKVKIFPDVPQALSELRTMGLKLAAVSNASQDCTEFVLELFNLRKYFDAVFGKDYSYLDGVKPNPHLILKSLKVLNVPPDKALVIGDSELDVKAAHRAGIKAVQVLRFDNFVEDADYHIRTLDELVDLVKKLVNEQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLA3</accession>
    <name>F0LLA3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00777</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00777"/>
    <dbReference type="EnsemblBacteria" id="ADT83754">
        <property type="protein sequence ID" value="ADT83754"/>
        <property type="gene ID" value="TERMP_00777"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00777"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.779"/>
    <dbReference type="eggNOG" id="arCOG00934">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062674_0_1_2"/>
    <dbReference type="OMA" id="GGEPTPN"/>
    <dbReference type="OrthoDB" id="34153at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="122"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="348" mass="40841" checksum="3167B63C2B98F100" modified="2011-05-03" version="1">MWFRRVDIGEIEKAKRAMPHYFEVLSGKEKPNFFYVKQVKVDFSKDDPLEELWNIHEEGMEKLRENDLSESPEKSLLDLKALIADRILEKCELCEIKCHVNRKESIGYCRVKDTLIASDFLHIGEEPELIPSYTIFFSGCNFRCVFCQNWDISQYRVGLRYSPEDMATKIAVAYAEGAKNVNFVGGEPTPNLPFILETLRYVKVPIPVVWNSNMYMSEIAMRLLDGIVDVYLADFKWGNNEDAIKYSKAPRYWEVVTRNFLLAKKHYKAEFLIRHLVMPNHLECCTKPILKWISENLGKEVRVNVMFQYRPEYRADRYPEIARRLNYEEMQRAAELAAEFELKNAMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLH4</accession>
    <name>F0LLH4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468299.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02029"/>
    <dbReference type="EnsemblBacteria" id="ADT85003">
        <property type="protein sequence ID" value="ADT85003"/>
        <property type="gene ID" value="TERMP_02029"/>
    </dbReference>
    <dbReference type="GeneID" id="10042344"/>
    <dbReference type="KEGG" id="tba:TERMP_02029"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2026"/>
    <dbReference type="eggNOG" id="arCOG05786">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098181_0_0_2"/>
    <dbReference type="OMA" id="VKPGYYW"/>
    <dbReference type="OrthoDB" id="100845at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018663">
        <property type="entry name" value="DUF2101_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09874">
        <property type="entry name" value="DUF2101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="255" mass="30193" checksum="88EBDCDCC7E2BB60" modified="2011-05-03" version="1">MNPEELFYKVGEFVEATWERVKDFTNPKPQEKPPSFKLLRKLVKKKVTVHELLVLKLQLTFLFYMFLALLLVVFLPNELYLVILTAVYFIYLRVIFRKYREFFIEHEPYQVFYYSISIIGFLAFFGYVLLKRFSLDIRYSLGYLVFVFVAVLMFRFYFKSKYGRDWTYGVIEDIKENVVKISVHDDIRANVKPGEYWVDKVPDVEIGRIVKVLVEERAFRGAVPTKIIEVYLSDQPSSSKASTEAKEDKESNKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLK6</accession>
    <name>F0LLK6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468331.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02061"/>
    <dbReference type="EnsemblBacteria" id="ADT85035">
        <property type="protein sequence ID" value="ADT85035"/>
        <property type="gene ID" value="TERMP_02061"/>
    </dbReference>
    <dbReference type="GeneID" id="26137675"/>
    <dbReference type="KEGG" id="tba:TERMP_02061"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2058"/>
    <dbReference type="eggNOG" id="arCOG02270">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166740_2_0_2"/>
    <dbReference type="OMA" id="EDVWIEY"/>
    <dbReference type="OrthoDB" id="129142at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="71" mass="7952" checksum="3A05A633D2164523" modified="2011-05-03" version="1">MKISYDPKYDVMYIKFSDAKIVDTVEVDEGIIIDYGEHGEIVGIEIINASVKIKPKPLSEITIKIEEQAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLL8</accession>
    <name>F0LLL8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribulose bisphosphate carboxylase</fullName>
            <shortName evidence="1">RuBisCO</shortName>
            <ecNumber evidence="1">4.1.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbcL</name>
        <name evidence="4" type="ordered locus">TERMP_00818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2R)-3-phosphoglycerate + 2 H(+) = CO2 + D-ribulose 1,5-bisphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:23124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="4.1.1.39"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 1,5-bisphosphate + O2 = (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:36631"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58033"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuBisCO large chain family. Type III subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.39" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467093.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00818"/>
    <dbReference type="EnsemblBacteria" id="ADT83795">
        <property type="protein sequence ID" value="ADT83795"/>
        <property type="gene ID" value="TERMP_00818"/>
    </dbReference>
    <dbReference type="GeneID" id="26136270"/>
    <dbReference type="KEGG" id="tba:TERMP_00818"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.820"/>
    <dbReference type="eggNOG" id="arCOG04443">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031450_3_1_2"/>
    <dbReference type="OMA" id="IHGHPDG"/>
    <dbReference type="OrthoDB" id="9533at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016984">
        <property type="term" value="F:ribulose-bisphosphate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08213">
        <property type="entry name" value="RuBisCO_large_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01133">
        <property type="entry name" value="RuBisCO_L_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033966">
        <property type="entry name" value="RuBisCO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017712">
        <property type="entry name" value="RuBisCO_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000685">
        <property type="entry name" value="RuBisCO_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036376">
        <property type="entry name" value="RuBisCO_lsu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017443">
        <property type="entry name" value="RuBisCO_lsu_fd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036422">
        <property type="entry name" value="RuBisCO_lsu_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42704">
        <property type="entry name" value="PTHR42704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00016">
        <property type="entry name" value="RuBisCO_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02788">
        <property type="entry name" value="RuBisCO_large_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00014">
        <property type="entry name" value="RuBisCO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51649">
        <property type="entry name" value="SSF51649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54966">
        <property type="entry name" value="SSF54966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03326">
        <property type="entry name" value="rubisco_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuBisCO_large_N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="RuBisCO_large" evidence="2">
        <location>
            <begin position="143"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="367"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="389"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="444" mass="49883" checksum="8912158B172E6588" modified="2011-05-03" version="1">MSEKFDKIYDYYVDKSYEPNKKRDIIAVFRITPAEGYSIEAVAGGVAAESSTGTWTTLYNWYEEERWADLSAKAYDFHDMGDGSWIVKIAYPFHAFEEANLPGLLASIAGNIFGMRRAKALRLEDIYFPEKLIREFDGPAFGMEGVRKMLEIKDRPIYGVVPKPKVGYSPEEFEKLATELLMNGADYMKDDENLTSPWYNRFEERAEIIARIIEKVENETGEKKTWFANITANVPEMEERLEILADLGLKHAMVDVVITGWGALQYIRDLAADYGLAIHGHRAMHAAFTRNKYHGISMFVLAKLYRLIGIDQLHVGTAGAGKLEGGKWDVIQNARIFRESHYKPDENDVFHLEQKFYHIKAGFPTSSGGLHPGNLPIVFDALGTDIVIQVGGGTLGHPDGPAAGARAVRQAIDAYMQGIPLDEYAKTHEELARALEKWGHVTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLM3</accession>
    <name>F0LLM3_THEBM</name>
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        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ordered locus">TERMP_00823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvB family.</text>
    </comment>
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    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00823"/>
    <dbReference type="EnsemblBacteria" id="ADT83800">
        <property type="protein sequence ID" value="ADT83800"/>
        <property type="gene ID" value="TERMP_00823"/>
    </dbReference>
    <dbReference type="GeneID" id="10041141"/>
    <dbReference type="KEGG" id="tba:TERMP_00823"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.825"/>
    <dbReference type="eggNOG" id="arCOG04081">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_2"/>
    <dbReference type="OMA" id="YDMGAKM"/>
    <dbReference type="OrthoDB" id="17080at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="PTHR11093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="62"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="441" mass="48814" checksum="B1AF712C49C803A1" modified="2011-05-03" version="1">MAVIEEIAKVSFERVGSHSHIKGLGLDENGKAKFIADGMVGQIKAREAAGIAVKLIKRGKLAGKGILLVGPTGSGKTAIAIGIAKELGEDVPFVQISGSEIYSAEIKKTEFLKQALRRAIGVRISEERKVYEGKVEKIEIRRTRHPFNPYVEIPESVILTLRTKDDEKTIRAGREIAYQLLDLGIEEGDVIQIDAESGRISKIGTTKEEEGIFLKKKVEMPSGPVLKIKEFTYTVTLHDLDVVNARAGGIFTLIFGGGLEITDEVRERVDETVKGWVEEGKAVLVPGVLFIDECHMLDIEAFSFLARAMESELAPILILATNRGKTKIRGTDIEAPHGIPIDMLDRLLIINTEPYKKDEIREIVKIRAREEGIDISDEAIEYLAELGEKTSLRYAVQLLAPSSIIAQGQKVKKEHIMKAQGYFADIKRSISYVEKLEGMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLR6</accession>
    <name>F0LLR6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467141.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00866"/>
    <dbReference type="EnsemblBacteria" id="ADT83843">
        <property type="protein sequence ID" value="ADT83843"/>
        <property type="gene ID" value="TERMP_00866"/>
    </dbReference>
    <dbReference type="GeneID" id="26136316"/>
    <dbReference type="KEGG" id="tba:TERMP_00866"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.869"/>
    <dbReference type="eggNOG" id="arCOG02316">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100860_0_0_2"/>
    <dbReference type="OMA" id="EPTVHMK"/>
    <dbReference type="OrthoDB" id="71317at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014424">
        <property type="entry name" value="UCP004897_ACT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004897">
        <property type="entry name" value="UCP004897_ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="106"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="166" mass="18826" checksum="3B8632BFB24DECCE" modified="2011-05-03" version="1">MWGKIEHYFDEYPVRKQIAKTLLKYGLKVSDDMKIKCGNIEVPYTKIAKALDVDRRVVKETVAMILKIPELREIYTNLEPTVHMKFVGRHVGYGVIEIEPEPRAIGILAKIAGKIAERGINIIQVVAEDPELYPEATLTIITEKPIPGDLINELSKLEGVKRISIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLU8</accession>
    <name>F0LLU8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468343.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02073"/>
    <dbReference type="EnsemblBacteria" id="ADT85047">
        <property type="protein sequence ID" value="ADT85047"/>
        <property type="gene ID" value="TERMP_02073"/>
    </dbReference>
    <dbReference type="GeneID" id="10042388"/>
    <dbReference type="KEGG" id="tba:TERMP_02073"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2070"/>
    <dbReference type="HOGENOM" id="CLU_1727325_0_0_2"/>
    <dbReference type="OrthoDB" id="134587at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="151" mass="17289" checksum="3D9664DF2A483D9F" modified="2011-05-03" version="1">MGMFDYVHIYVKCPVCGHKLKTFQTKSLENMLEHYKVGDTVNADRIHAYTSCPFCHSFIDIEIKVENGKITDGYDVISVKRSWIVEILKKIGKRVTLTLYVGTSSGWKNVISLDLNNHEAIAVYNVLKKSFPRSPYYRKRNVPAVKGFQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLY3</accession>
    <name>F0LLY3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468378.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02108"/>
    <dbReference type="EnsemblBacteria" id="ADT85082">
        <property type="protein sequence ID" value="ADT85082"/>
        <property type="gene ID" value="TERMP_02108"/>
    </dbReference>
    <dbReference type="GeneID" id="10042423"/>
    <dbReference type="KEGG" id="tba:TERMP_02108"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2105"/>
    <dbReference type="eggNOG" id="arCOG02219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171554_0_0_2"/>
    <dbReference type="OMA" id="YDTNVLI"/>
    <dbReference type="OrthoDB" id="119184at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="110" mass="12303" checksum="8FD22DB10F238CC5" modified="2011-05-03" version="1">MEAPKKLYDTNVIINAVKSSERLKGYTTILNIVEFPRGSELDLTVLTPSLDDYLLAIEISQTMVERGTPVPAVDAVIAAVALNRDLTIVTRDKHFSFIQKAYPRLKIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM00</accession>
    <name>F0LM00_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468395.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02125"/>
    <dbReference type="EnsemblBacteria" id="ADT85099">
        <property type="protein sequence ID" value="ADT85099"/>
        <property type="gene ID" value="TERMP_02125"/>
    </dbReference>
    <dbReference type="GeneID" id="10042440"/>
    <dbReference type="KEGG" id="tba:TERMP_02125"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2122"/>
    <dbReference type="eggNOG" id="arCOG08355">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG09679">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000749_0_0_2"/>
    <dbReference type="OMA" id="AYLEPTN"/>
    <dbReference type="OrthoDB" id="1283at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="2030" mass="222030" checksum="1FCEA4ACCF8F5B20" modified="2011-05-03" version="1">MNRRNRARFLSVLLAVLMLLSAVPMFTPEVVAQTYPTTIKIVGNATNCGVKLFQGFPYEIVMNISYLDSSGNVTAISSNVYARIYYYNTTSGSWILAYETPDPGFSVQNGNATIIINSTLSPGFVSNEYREIPQGITMLRVTLYDPVYNISASTDFAVLFPYTVSTTITSTVPYLNGTWMYDRAFKEIPFNLTVNVTYDSDAVTCFGIAIPSNVTVDITMPNGSVISDTLPLTNGTGEKVYANLESSVPGTGNVVVTDSLNGLTAPPEYFQVYDWNINFFTISFSLTYPPYAWIPFNLSGTVNAYTTFGGLGTYTLGVNDTIYLVLLNNTIFNTTAIMTNGTAPFNITDIILPGGTDYALYASMGNYSPETTYYFNVSSWDIEITPTITCTSGGAVCDYFYAGVNQTLNITINYPVSPYNITSTANYSVLLNGVEMYSGNITIINNTGSVEFPVNFPENGTVVVKVWDETYHPEVNNVTLEVKDWGIGYGYLVEHYPGTWYSVFDDKFYVGIPADLNLTILYNEPCPVNSTLEITLLLPNGTVLTYNVTVTDSNMTNFAVPQTFLFSEPGFVVVTYNDTTLGKSVTFSIPVRDWGIFVDASPEELTQDESVNLNVFVVESLYFDWPGERNVTVTLELPDGYVETKNLTLEANDDIYGGQGGYQGIITFENVTPTMPGIAWVTVTDVLSGKSVKMPIKVNAAITPGNKWIDVTATPANEPVYAYIGNSLRIELQYMYSDGIAAYKDYDDHIVNVTITDADGTEYFLQLPVDNGYLLIPSYAIPVNGTNDIAIEVVDAYNSSITGGTVVPVTQWNVTFDFATNGTVWEYVDNTLYVTVHVNGPNVPVDVSINGDLYTNVADGQVIEYPITDPQGTLVYNVIATYNGHQVGSDTYTVLPQEWNVTFDFATNGTVWEYVDNTLYVTVHVNGPNVPVDVSINGDLYTNVADGQVISVDIVDPMGILTYNVTAIYNGHQVSDEWIHLIQVRSWNVTFEFSYADAATGIGELYQGFNARLNVTVHVNGPDVPVDIWWWTWNLGNYTDGSVLYLGFGPVPAVITQQFKATYEGHIVGNDTFVYSSATWSTEVSAPDELYYLPDGYTNMDVKIGVDLAGLPEIITGGYNVTIELNVTLPNGTVIHRVVNGTNSTVFDLGDLTFNESGVVTYVVKVYKHVPWPGGPLYEVGSASGTIPIELALDAVITGTYYENIPMDFVVNVYSISDSPDITVTISGTNYTVTADHDGVLTIPNVTLEAGNYTVIITDASLNATITRTLEVRNWGIYVVPTPTNITAGSVYTVTFDISLIDQYGQPVVVNDKIRLRLEFSDTDIIPSGFYDLVYYMDIADNGHLTKTVSVFSPVAGTFQVIVSDKYGKMNNTEQIIVNEPNPADLTYVYVNIRKQGSLNPPEEPVKLYWGLELGGVRKYFPVFNATISDDYSEAMFALYPQSPFSLYVIATPLNVTAPILTENEPWVSNITVQNETITTYTKNVTVIPIEDGWNISVSVYKATLHNVTIEHYLYNVPITPGVIQLQPGSASVQGNAIYAGLSVEPEHYEEYIFGPYETANSTMITIEPNELMLMLIDNTTLKPTQAGEYFTFKAMLSITNAEEQFNAQWMPFESWIQAIGFLNDTEKGEIISEILDQIGNVSALNGPVANETLDFHIDNTDIAYLEPTNATTDEMGSVVFKVYTQATPDMTPEELSTLMGAVDVWATYGDLESNHITVNFGGTGSISGDITDDSGMQIAGATVIVKIWNGTAWVNATDFEGNVLVTVSAEDGHYALNNVPAEKNGTEYMVVAKKGNLTGYAYVTVYPFATSTADIKLGGEAQYAGIAMYKEKVETADTVYFVFNNLGTPDAFSVSQYVSRTVPITTRTVSLLAEDFNMSAVTANDVVISVGGPLVNPVTAAYENIAPVHMVIDGKDITIVSPQGNVTWTAPTPWWNVTEGYFIIQLFTDENSGALVVTIYGTDADSTAAGAYYFLTEVYPNIAAYNSISYIVGKWEDTEAGADIPLPGANLGDTSGFSAGDTITVIFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM04</accession>
    <name>F0LM04_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_02129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02129"/>
    <dbReference type="EnsemblBacteria" id="ADT85103">
        <property type="protein sequence ID" value="ADT85103"/>
        <property type="gene ID" value="TERMP_02129"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02129"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2126"/>
    <dbReference type="eggNOG" id="arCOG00562">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020247_0_0_2"/>
    <dbReference type="OMA" id="FTEYFRY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="76"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT85103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="636" mass="74472" checksum="E9135240D0BE3131" modified="2011-05-03" version="1">MWKRSEIVPVIIFIVAFLIRVRNLSRPFTEYFRYINAQYATYARNYIWYGYLKTKFGLVSTPCYINNTDNFSYYFHHPPMISILTSIYFRLFGISESSVRLTEISLSMLTLLMIYIISKTIWNKSVAIVSMFIFAFLPISAYYDRIIAPDYSIMPFVLATVYFYIRYHQTLKSENLYLMALFLYIATWFDWQAYLIIPGVLLHSLMKDKLSKFSIRIGIFLIVGAFLGFISYLLFVYLLGGSHEIIELYQGFLTRSGIRIYRKFDRPGATYKFTIIQFMMLEIKRSINLFTSVILVFTLIWITYFVLTKLENDGYLIPFWIHGILSIFLFRQGAWIHDFWLYQLVPAIVFSSSKGILVFFRTLSAKRSYLTSLPLSILTASACILGTLWSLFLVAVLKTFHSSNIDEISLLILIIASIGAYLMFWLIISHNITVEDENNIENNLRKSFPVLLLSVLFISYLKNILYPRVPYYGLIIILSVLVLGVLWYITVVKQYVSVGFLKFFGILIVLMLFVYQALYVIHIRDSWVYPAEYRKGLIIKNITTPNDRIFAIPEAGIHSYSSTFYSERCVVLIWTLRDLIKNINVTTDETGYMYLVSTEDLFKDKKYQTLEEHLMDNYPYLKIGDLYIFNLSTINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM07</accession>
    <name>F0LM07_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468402.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02132"/>
    <dbReference type="EnsemblBacteria" id="ADT85106">
        <property type="protein sequence ID" value="ADT85106"/>
        <property type="gene ID" value="TERMP_02132"/>
    </dbReference>
    <dbReference type="GeneID" id="10042447"/>
    <dbReference type="KEGG" id="tba:TERMP_02132"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2129"/>
    <dbReference type="eggNOG" id="arCOG01105">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1500349_0_0_2"/>
    <dbReference type="OrthoDB" id="94641at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="28"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="179" mass="20744" checksum="98583DA538008EE4" modified="2011-05-03" version="1">MERFEIDREVEEKVDQILQKLVKLPLEKILSYALKGEEDAIQLYKFLSQHIEEPHAKMKFEQFIKIESGHKKKIRKVFEELFPGVEPSEIPLPSWVEVSFQDVRKDIKTAEDYLSILKVAISSEKLAEKSINLLPKLSSKSTLICSLHLLKMKGSITIFLLTSISFISVPKLKRICMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM08</accession>
    <name>F0LM08_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468403.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02133"/>
    <dbReference type="EnsemblBacteria" id="ADT85107">
        <property type="protein sequence ID" value="ADT85107"/>
        <property type="gene ID" value="TERMP_02133"/>
    </dbReference>
    <dbReference type="GeneID" id="10042448"/>
    <dbReference type="KEGG" id="tba:TERMP_02133"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2130"/>
    <dbReference type="eggNOG" id="arCOG01102">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1792224_0_0_2"/>
    <dbReference type="OMA" id="ETFATYE"/>
    <dbReference type="OrthoDB" id="89236at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="14"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="146" mass="17516" checksum="9B4C38CB386FEAE6" modified="2011-05-03" version="1">MKVQELLEKIAWQENELYNLYKLGETFAVYETPRLAEHFNWLASEELRHRNTVQTFIKEKTLENSAVIDHLDALSLEPYLTDERVEPEDLEDLILEALIREKHSYELYQKLSEILDGSLSQIFRMMSQEELKHAYRLKIMYETVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM29</accession>
    <name>F0LM29_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467174.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00900"/>
    <dbReference type="EnsemblBacteria" id="ADT83876">
        <property type="protein sequence ID" value="ADT83876"/>
        <property type="gene ID" value="TERMP_00900"/>
    </dbReference>
    <dbReference type="GeneID" id="10041217"/>
    <dbReference type="KEGG" id="tba:TERMP_00900"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.901"/>
    <dbReference type="eggNOG" id="arCOG00056">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_795999_0_0_2"/>
    <dbReference type="OMA" id="ESRYQIQ"/>
    <dbReference type="OrthoDB" id="27531at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd11718">
        <property type="entry name" value="THUMP_SPOUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041730">
        <property type="entry name" value="MJ0421-like_THUMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025849">
        <property type="entry name" value="SPOUT_MTase_fused_to_THUMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14419">
        <property type="entry name" value="SPOUT_MTase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="46"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="348" mass="40140" checksum="E8688B6EF5FFD8DB" modified="2011-05-03" version="1">MKFLIKTQRGMEAVAGNYIKEALEDSKVWISPQGYSGLILVETDDKNAKEKILEIPEVERVIEVLHEVPAKIEDILNVAEDLAKFINEGETFAVKTKRRGKHDFTSVDVNVQLGAKIKELTNAEVDLSFPDKAILVEIIGDKAYISVVGKEEWKKYTPEKTDARKLFKKVSIVQMPYWGDYKACRNFGEKIGRAAQAFEVKELIIAPKEKIDGYELMEFLRGVKIGQESRYQIQREAYPWKIEKVPVYVWDLYQVIRDKRRNKRLLIITDPKGHTLAEVKDELAKDMYYAKEVVVFIGSREGIPRGLFRFADYVVDLAPYMTFATEHGIPGALIALWTIYEEELRRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM64</accession>
    <name>F0LM64_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00935"/>
    <dbReference type="EnsemblBacteria" id="ADT83911">
        <property type="protein sequence ID" value="ADT83911"/>
        <property type="gene ID" value="TERMP_00935"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00935"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.936"/>
    <dbReference type="eggNOG" id="arCOG04405">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154670_0_0_2"/>
    <dbReference type="OMA" id="KLYAWVL"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="120" mass="13960" checksum="01BB67D1E710026F" modified="2011-05-03" version="1">MREMKGLIVKEPFASWIVEGKKVWEIRKSRTKIRGEIFIISKKKAIGKVKLVDVLGPFTPEELADHKDKHLADYEFLKKYAKGKKLYAWVLSNPQKFEEPKEVIMANGAQIWVNIRGFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LME0</accession>
    <name>F0LME0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TsaA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_02189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468459.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT85163">
        <property type="protein sequence ID" value="ADT85163"/>
        <property type="gene ID" value="TERMP_02189"/>
    </dbReference>
    <dbReference type="GeneID" id="26137824"/>
    <dbReference type="KEGG" id="tba:TERMP_02189"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2184"/>
    <dbReference type="eggNOG" id="arCOG00761">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013458_2_0_2"/>
    <dbReference type="OMA" id="VCRLEIF"/>
    <dbReference type="OrthoDB" id="117039at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023368">
        <property type="entry name" value="UPF0066_cons_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818">
        <property type="entry name" value="PTHR12818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="SSF118196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00104">
        <property type="entry name" value="tRNA_TsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01318">
        <property type="entry name" value="TSAA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT85163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="164" mass="18524" checksum="D5F5AD440FCCC585" modified="2011-05-03" version="1">MKSNVICYKPIGIIHTPFKEPKGVPIQPSAARGIEGKVEVFPEYVQGLKDLEGFSHVVLIYHFHLAKPGSLFVKPYMDDEYHGVFATRAPSRPNPIGLSIVRLVKVRGNTLHVKDVDIVDGTPLLDIKPYVPDFDVREVERIGWLENNIHKLSKARDDGRFIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMI0</accession>
    <name>F0LMI0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00983</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00983"/>
    <dbReference type="EnsemblBacteria" id="ADT83959">
        <property type="protein sequence ID" value="ADT83959"/>
        <property type="gene ID" value="TERMP_00983"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00983"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.986"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OMA" id="AGDENYI"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="151" mass="17075" checksum="E378E66D53E8712B" modified="2011-05-03" version="1">MVRATLDDTDKKILGILQKNSRTPLREISKAVGLAESTIYERIKKLKENGVIKKFTVILDPEALGFTMLSFILIKAKAGKYAYVAKELVKYPEIVEIYETTGDYDMIVKIRTRGSEELNEFLDKIGEIDGVEATHTMVVLKVHKETTELPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMJ5</accession>
    <name>F0LMJ5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psmB</name>
        <name evidence="11" type="ordered locus">TERMP_00998</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467272.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00998"/>
    <dbReference type="MEROPS" id="T01.002"/>
    <dbReference type="EnsemblBacteria" id="ADT83974">
        <property type="protein sequence ID" value="ADT83974"/>
        <property type="gene ID" value="TERMP_00998"/>
    </dbReference>
    <dbReference type="GeneID" id="26136447"/>
    <dbReference type="KEGG" id="tba:TERMP_00998"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1001"/>
    <dbReference type="eggNOG" id="arCOG00970">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_2_2"/>
    <dbReference type="OMA" id="HKQAYAI"/>
    <dbReference type="OrthoDB" id="89767at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03764">
        <property type="entry name" value="proteasome_beta_archeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03634">
        <property type="entry name" value="arc_protsome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7 9 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8 9" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005049563" description="Removed in mature form; by autocatalysis" evidence="9">
        <location>
            <begin position="1"/>
            <end position="6"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023365568" description="Proteasome subunit beta" evidence="9">
        <location>
            <begin position="7"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="199" mass="22039" checksum="311D53298762A02C" modified="2011-05-03" version="1">MEKKTGTTTVGIKVKEGVVLAADTQASLDHMVETLNIKKILPITDRIAITTAGSVGDVQMLARMLEAEARYYQFTWGKPMTAKAMANLLSNILNENKWFPYLVQIIIGGYVEEPTLANLDPLGGLIFDDYTATGSGSPFAIAILEEGYRKDMSIEEARELAIRAVRTAGKRDVYTGDRKIQVVVITKEGMKEEFVEFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMJ8</accession>
    <name>F0LMJ8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA/RNA-binding protein Alba</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">albA</name>
        <name evidence="9" type="ordered locus">TERMP_01001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467275.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01001"/>
    <dbReference type="EnsemblBacteria" id="ADT83977">
        <property type="protein sequence ID" value="ADT83977"/>
        <property type="gene ID" value="TERMP_01001"/>
    </dbReference>
    <dbReference type="GeneID" id="34862763"/>
    <dbReference type="KEGG" id="tba:TERMP_01001"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1004"/>
    <dbReference type="eggNOG" id="arCOG01753">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110989_1_0_2"/>
    <dbReference type="OMA" id="QFNEGAK"/>
    <dbReference type="OrthoDB" id="111461at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01122">
        <property type="entry name" value="AlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013795">
        <property type="entry name" value="DNA/RNA-bd_Alba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028732">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00285">
        <property type="entry name" value="TIGR00285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Alba" evidence="8">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="7">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="91" mass="10120" checksum="35115DC3F3706A5C" modified="2011-05-03" version="1">MAEEHVVYIGKKPVMNYVLAVITQFNEGAKEVSIKARGRAISRAVDVAEIVRNRFLPEVRVKEIKIGTEELPTADGRTANTSTIEIILEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMN5</accession>
    <name>F0LMN5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A</fullName>
            <shortName evidence="1">5-OPase subunit A</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="2" type="ordered locus">TERMP_01038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01038"/>
    <dbReference type="EnsemblBacteria" id="ADT84014">
        <property type="protein sequence ID" value="ADT84014"/>
        <property type="gene ID" value="TERMP_01038"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01038"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1041"/>
    <dbReference type="eggNOG" id="arCOG05810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069535_0_0_2"/>
    <dbReference type="OMA" id="DRTYKQD"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="258" mass="28766" checksum="A0641B8FD2A7C3C8" modified="2011-05-03" version="1">MVMLMKVDLNSDLGESFGRYKLGMDEEVMKYVTSANVACGWHAGDPLVMRKTVKLAKENNVEVGAHPGYPDLIGFGRRYMKITREEARNYILYQIGALYAFVKAEGLTLQHVKPHGALYNALVKDEELARGVLEGIADFDKKLIFVGLSLSKPLEIAEEMGLRVAHEVFADRAYNPDGTLVPRSREGAVIHDKELIAERVISMVKDGGVKAINGEWVELKADTICVHGDNPKALEITAYIRKRLEEEGVKIVPMRKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMQ4</accession>
    <name>F0LMQ4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467331.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01057"/>
    <dbReference type="EnsemblBacteria" id="ADT84033">
        <property type="protein sequence ID" value="ADT84033"/>
        <property type="gene ID" value="TERMP_01057"/>
    </dbReference>
    <dbReference type="GeneID" id="10041374"/>
    <dbReference type="KEGG" id="tba:TERMP_01057"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1060"/>
    <dbReference type="eggNOG" id="arCOG02706">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_5_2_2"/>
    <dbReference type="OMA" id="IHHICYE"/>
    <dbReference type="OrthoDB" id="100669at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="133" mass="14768" checksum="DC2812EFB65D0D08" modified="2011-05-03" version="1">MIKKIDHVGIAVKNLDEAIKLWESLGLKVAEIEEVPEQKVRVAVFKVGESRIELLEGTSEDSPISKFIAKRGEGIHHIALGVENIEEHLEKLKEQGFRLIDEKPRIGAGGAKIAFVHPKSVNGVLLELCERTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMQ5</accession>
    <name>F0LMQ5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArgK-like periplasmic protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467332.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01058"/>
    <dbReference type="EnsemblBacteria" id="ADT84034">
        <property type="protein sequence ID" value="ADT84034"/>
        <property type="gene ID" value="TERMP_01058"/>
    </dbReference>
    <dbReference type="GeneID" id="10041375"/>
    <dbReference type="KEGG" id="tba:TERMP_01058"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1061"/>
    <dbReference type="eggNOG" id="arCOG01226">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043725_1_0_2"/>
    <dbReference type="OMA" id="WMWERID"/>
    <dbReference type="OrthoDB" id="80898at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="44"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="319" mass="35271" checksum="505E88F3956C0EDB" modified="2011-05-03" version="1">MIDNLIERMLKGDKKATARLITLVENDEEKAREIVKKIYKYTGKAYIIGITGPPGSGKSTLLDKLIKQARNEGLIVGVIAIDPTSPFTGGALLGDRIRMQRHSTDPGVFIRSMATRGSLGGLAKATNDAIKVLDAYGCDVIFVETVGVGQIEVDIVKTADTVVLVTVPGLGDDIQAIKAGLMEIADIFVINKADKEGADATFFELNLLLDLEKEKWERRGWRPPIVETVAVTMKGIKDLWEAIKRHRKFLEESGEIKKKKKFRAEEEVKTIVSDSVARKISEKLKDKELSKLIDKIVKREIDPYSAAEVVLEETLGVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMR7</accession>
    <name>F0LMR7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="7">TC-AMP synthase</shortName>
            <ecNumber evidence="4 7">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_01070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4 7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467344.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01070"/>
    <dbReference type="EnsemblBacteria" id="ADT84046">
        <property type="protein sequence ID" value="ADT84046"/>
        <property type="gene ID" value="TERMP_01070"/>
    </dbReference>
    <dbReference type="GeneID" id="26136520"/>
    <dbReference type="KEGG" id="tba:TERMP_01070"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1073"/>
    <dbReference type="eggNOG" id="arCOG01952">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_0_0_2"/>
    <dbReference type="OMA" id="GMLKSHY"/>
    <dbReference type="OrthoDB" id="52427at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="9">
        <location>
            <begin position="13"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT84046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="341" mass="37557" checksum="8261BF21F595D5E0" modified="2011-05-03" version="1">MTIVINMRDRVDNRKIKIAAKFIREGKLVAFPTETVYGLGADALNEKAVRRIFEAKGRPADNPLIVHIARFEQLYELARNVPREAEILAEHFWPGPLTIVLPKKDNVPKTTTGGLDTVAIRMPAHEIALNLIKASGRPIAAPSANISGKPSPTLAEHVVDDFYGRIECIIDGGEVKIGVESTVLDLTTKPPTLLRPGGLPLEEIERIIGRIKIHPAVKGKTVDIAKAPGMKYKHYAPNAQVIVIEGNREKVKEKIKELLKEYKKRGIKVGIMATGDFYEADAYVNLGNSEEEVAKNLFRALRELDKSGVDVILAEGIEEKGLGLAVMNRLRKAAGYKIVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMT3</accession>
    <name>F0LMT3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467360.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01086"/>
    <dbReference type="EnsemblBacteria" id="ADT84062">
        <property type="protein sequence ID" value="ADT84062"/>
        <property type="gene ID" value="TERMP_01086"/>
    </dbReference>
    <dbReference type="GeneID" id="10041403"/>
    <dbReference type="KEGG" id="tba:TERMP_01086"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1089"/>
    <dbReference type="eggNOG" id="arCOG01369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="308" mass="34320" checksum="7740138AC6EF606A" modified="2011-05-03" version="1">MIKNKLIVVTGGAGFIGSHIAEELSEDNEVVVIDNLYSGKVENVPENVKFIQADIRDYESIAEIISQADYVFHEAALVSVVESVEKPILTEEINVLGTLNILKALSEGHGKLIFASSAAVYGDNQNLPLKEDEKPKPLSPYGVTKVSGEYYCRVFYELYGVPTVTLRYFNVFGERQGYNQYAGVISIFINRALKNEPLIIFGDGKQTRDFIYVKDVVKANILVAEKEKANGEVFNVARGERTTILELAMKIIDATNSSSSIIFDKPRPGDIKHSQADISKIKKLGFKPDYSLKEGLLRTIEWYRGQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMZ9</accession>
    <name>F0LMZ9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase accessory CooC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467426.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01152"/>
    <dbReference type="EnsemblBacteria" id="ADT84128">
        <property type="protein sequence ID" value="ADT84128"/>
        <property type="gene ID" value="TERMP_01152"/>
    </dbReference>
    <dbReference type="GeneID" id="10041469"/>
    <dbReference type="KEGG" id="tba:TERMP_01152"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1155"/>
    <dbReference type="eggNOG" id="arCOG00587">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082962_0_0_2"/>
    <dbReference type="OMA" id="LTMGTVD"/>
    <dbReference type="OrthoDB" id="61135at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014433">
        <property type="entry name" value="CooC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005647">
        <property type="entry name" value="CooC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="268" mass="29079" checksum="FF7B0BD68C58CB93" modified="2011-05-03" version="1">MKILVAGKGGVGKTTISALLAHILADKGYNILALDTDSVPNLAQSLGVPFEEALEIVPLSRNEKLAEERTGARPGEGWGVLFSLTPKVDDLAEQYGITIKPNLKLVVVGSIEQSKEGCLCPALALARAFLMHVLLSEKDIVIVDSEAGAEVFGRGLAEKFDVMICVAEPTLKSLLIARKLIEMGKQLNISNIFLVINKVRNSLKASQLYAKVFSDSTPYHLVNFDESVINVDNKGKGVDSIPKDSPIYEDVEALARRILNVKKRSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN29</accession>
    <name>F0LN29_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type multidrug transport system ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467456.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01182"/>
    <dbReference type="EnsemblBacteria" id="ADT84158">
        <property type="protein sequence ID" value="ADT84158"/>
        <property type="gene ID" value="TERMP_01182"/>
    </dbReference>
    <dbReference type="GeneID" id="10041499"/>
    <dbReference type="KEGG" id="tba:TERMP_01182"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1185"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="CEGYRRP"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="330" mass="37621" checksum="24A2ABA7C40E1BBF" modified="2011-05-03" version="1">MEYAITADNLVKKYGDFTAVKGVSFKVKKGEIFAFLGPNGAGKTTTIHMLVTLLKPTSGNATVAGHDVIKEPDKVRKKIGIVFQDPSLDRELTAYENMYIHGKIYGLSGDKLKKRIMEMLKFVELDEFKDRQVKFFSGGMQRRLEIARALIHEPEVLFLDEPTIGLDPQTRAHIWEYIKKMKEEHEMTIFLTTHYMDEAEQLADRIAIIDHGRIIAEGTSEELKKLVGNDVIYIRIANGKEEVKCLNADFIRGCKVLPDGRVRLEVANAAEALPKLFELAQQNDIKILEVTYHRPTLNDVFLYLTGRELREESAGGFDMAKIAVRRRYMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN42</accession>
    <name>F0LN42_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467469.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84171">
        <property type="protein sequence ID" value="ADT84171"/>
        <property type="gene ID" value="TERMP_01195"/>
    </dbReference>
    <dbReference type="GeneID" id="10041512"/>
    <dbReference type="KEGG" id="tba:TERMP_01195"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1198"/>
    <dbReference type="eggNOG" id="arCOG01009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2581594_0_0_2"/>
    <dbReference type="OMA" id="AEDWNND"/>
    <dbReference type="OrthoDB" id="126392at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="92" mass="10268" checksum="C0703E1519354D7E" modified="2011-05-03" version="1">MSASSVKITVRIPAGIAKMIDELVEAGLYSNRSEVVKEALREFVLSKKIPNAKSQDEDEKFIKSMLKVIEPILAEDWNNDPDDYVGGVPYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN46</accession>
    <name>F0LN46_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4268 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467473.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01199"/>
    <dbReference type="EnsemblBacteria" id="ADT84175">
        <property type="protein sequence ID" value="ADT84175"/>
        <property type="gene ID" value="TERMP_01199"/>
    </dbReference>
    <dbReference type="GeneID" id="10042558"/>
    <dbReference type="KEGG" id="tba:TERMP_01199"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1202"/>
    <dbReference type="eggNOG" id="arCOG06885">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07683">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_768609_0_0_2"/>
    <dbReference type="OMA" id="TERRATC"/>
    <dbReference type="OrthoDB" id="39549at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025364">
        <property type="entry name" value="DUF4268"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14088">
        <property type="entry name" value="DUF4268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4268" evidence="1">
        <location>
            <begin position="221"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="371" mass="43302" checksum="737FF762084FE6BC" modified="2011-05-03" version="1">MSYVVIKNSSNIEIIEEENFSADKREEYLHKLIEGTPQIILKDIAERDVKTLASHLRLPSGGELDLLLVDSSGSLTIVELKRGKGHREAIAQLLDYASDLQQMDENEIFNSGKTQFNSLEEVFRSFYGNGEEYSYEEFRQNFLKSIKDPMKIQLVLASYIIGDDTKRLVEWLRNFGINILCVEFEYYKSEDKEIFVPKLLDIGDIKKASSKKTLTETQKKYLRFFSEILSRFKEIEEGATERRATCDNWLQIPTGFGPIHFEWLFRGREPNKMLEVGLHFEDVNEMLNQKLLEYFKSKEEGLRKEIMDIKFGKLGSKWRKIYVEKLVGSLDNALNDENIKEWAVMMMVKFYEVFKKRGEIDKAIQIVKSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN62</accession>
    <name>F0LN62_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747423.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT85201">
        <property type="protein sequence ID" value="ADT85201"/>
        <property type="gene ID" value="TERMP_02228"/>
    </dbReference>
    <dbReference type="GeneID" id="10549052"/>
    <dbReference type="KEGG" id="tba:TERMP_02228"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2222"/>
    <dbReference type="eggNOG" id="arCOG03808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096716_0_0_2"/>
    <dbReference type="OMA" id="FRKFCAR"/>
    <dbReference type="OrthoDB" id="75481at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="240" mass="27422" checksum="C25B52E973CB6EBE" modified="2011-05-03" version="1">MAMPRSIRECLGEIIPAGILLVSYNQYSLGWKVGIKLAKEEIDSGGFAIITNIAIPFRKFCARVNAAGLDIIKEGEQGKLAVINVFKEEVPYDFVYSLEDVDESTFIPKYVEVKKEIVKKYGLGKRKVIHVFATLDTLYTRFGEDVMRELFMARLYAGEELVLRGFNFWDVLIVNRDSIPKELHSWMVTISDYVIMTQGILKEQEFIENISVLKGVSKNFRPIVFQVRTSTISIPSEMIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN63</accession>
    <name>F0LN63_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747424.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT85202">
        <property type="protein sequence ID" value="ADT85202"/>
        <property type="gene ID" value="TERMP_02229"/>
    </dbReference>
    <dbReference type="GeneID" id="10549053"/>
    <dbReference type="KEGG" id="tba:TERMP_02229"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2223"/>
    <dbReference type="eggNOG" id="arCOG10970">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2091314_0_0_2"/>
    <dbReference type="OMA" id="MCNIALA"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="123" mass="14469" checksum="0E22249BA9DAD07F" modified="2011-05-03" version="1">MGGATLRNVMRMIAALENAPKIKKTFREIGGPCWTHKDYCKCEAEELCNLALAEFLGVNPGTALRSWRNLMFEMEELGIIETRLVENPRNRPRRLLKLTKDWREAFDEIYAKTTRELFEKWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN91</accession>
    <name>F0LN91_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AbiEi_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
            <plasmid evidence="2 3">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747452.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02257"/>
    <dbReference type="EnsemblBacteria" id="ADT85230">
        <property type="protein sequence ID" value="ADT85230"/>
        <property type="gene ID" value="TERMP_02257"/>
    </dbReference>
    <dbReference type="GeneID" id="10549081"/>
    <dbReference type="KEGG" id="tba:TERMP_02257"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2251"/>
    <dbReference type="eggNOG" id="arCOG04793">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082323_0_0_2"/>
    <dbReference type="OMA" id="PSAIAYW"/>
    <dbReference type="OrthoDB" id="72343at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018547">
        <property type="entry name" value="AbiEi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09407">
        <property type="entry name" value="AbiEi_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AbiEi_1" evidence="1">
        <location>
            <begin position="84"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="257" mass="29657" checksum="FAD40D9EC9CE438F" modified="2011-05-03" version="1">MNKMEVLTKLLELGEAFTIQEALDHLKIDRNLLKYYLKTLSEAGFIKRIGKGIYAITPDPNEPPSVHEFVLASLFVKPSAIAYWSALNYYGLTEQIPNITFVQTPRKRGYEKIVEFNNRKFKIVTVKPSKFFGLNTAKIGRRKVNITDPEKTIVDCLDKPRYCGGIIEVVKALKNASFNQEKLLQYAQRMENKAILKRLGYISERLGLGLEEKIQLSDKDRKSFSLLDPTMPAKGKFNYKWGLLVNVPKDYWEELEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGU6</accession>
    <name>F0LGU6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466283.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00007"/>
    <dbReference type="EnsemblBacteria" id="ADT82985">
        <property type="protein sequence ID" value="ADT82985"/>
        <property type="gene ID" value="TERMP_00007"/>
    </dbReference>
    <dbReference type="GeneID" id="26137861"/>
    <dbReference type="KEGG" id="tba:TERMP_00007"/>
    <dbReference type="HOGENOM" id="CLU_2784306_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT82985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="68" mass="7757" checksum="5553B60902F1A3F5" modified="2011-05-03" version="1">MHPMLYRSLLASALLFLVLGLIAMPFLKRGEPAFYANIIGMSLLLLFIIGISALQYKDARNRKIKKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGV8</accession>
    <name>F0LGV8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Altronate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466295.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00019"/>
    <dbReference type="EnsemblBacteria" id="ADT82997">
        <property type="protein sequence ID" value="ADT82997"/>
        <property type="gene ID" value="TERMP_00019"/>
    </dbReference>
    <dbReference type="GeneID" id="26137872"/>
    <dbReference type="KEGG" id="tba:TERMP_00019"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.18"/>
    <dbReference type="eggNOG" id="arCOG05317">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029189_1_0_2"/>
    <dbReference type="OMA" id="DVGWELF"/>
    <dbReference type="OrthoDB" id="27446at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007392">
        <property type="entry name" value="Gal/Altron_deHydtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04295">
        <property type="entry name" value="GD_AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GD_AH_C" evidence="2">
        <location>
            <begin position="6"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT82997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="394" mass="42486" checksum="047C2AE6EAEEB13D" modified="2011-05-03" version="1">MKLGEIKGWRRENGDFGIRNHIVVLSSVACANHAALEIARRTGAIPIIQEEGACGMFGEDRKRFLRCMANVGSHPNVAWTLVVGLGCEGIDAHQLADEISKRGRNAESLLIQELGMDKTVEKGIELVNRAKENLTPRRETAGVEELVIGLKCGASDYTSGLISNPSVGKAVDILIEYGGTAIITERLELVGAEQILARRAKSKEVAEDFLRRIKKAVEDVNKRGVDWIGSQPSMGNIKGGLTTIEEKSLGAVKKAGNAQLEGCLDYGEKPKGRGLYFMDGPGYDVKAVSGLMCAGSHIILFTTGLGTYLGSPVSPVIKITGNPTTARKLRDAIDVDLSILLEEIISRDASLDEILEIGGRMILEEIVRVANGKLTKAEKSQHIEFSIELTGIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH12</accession>
    <name>F0LH12_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01244"/>
    <dbReference type="EnsemblBacteria" id="ADT84220">
        <property type="protein sequence ID" value="ADT84220"/>
        <property type="gene ID" value="TERMP_01244"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01244"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1246"/>
    <dbReference type="eggNOG" id="arCOG04797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130792_0_0_2"/>
    <dbReference type="OMA" id="HADMQPF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="132" mass="15017" checksum="7F0CAE215530A967" modified="2011-05-03" version="1">MIANVIVDFEPFLVLILGLDLRYGYPLHGFFHTFIGGSLVALALAEVIAKFYKHLGKEISVKKLKITALSGVWLHIVLDSFLYTDIKPFFPLSWNPFYGVFSAFEVYGFCIVAFLLGMSLYLLINLKFHPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH15</accession>
    <name>F0LH15_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01247"/>
    <dbReference type="EnsemblBacteria" id="ADT84223">
        <property type="protein sequence ID" value="ADT84223"/>
        <property type="gene ID" value="TERMP_01247"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01247"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1249"/>
    <dbReference type="eggNOG" id="arCOG01791">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3178773_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="46" mass="5342" checksum="B2827BE043F36BAB" modified="2011-05-03" version="1">MRIYTFTELKELLKRAGFEIEKVYGGFDGRELSLKAPRIIVVARKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH78</accession>
    <name>F0LH78_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466338.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00062"/>
    <dbReference type="EnsemblBacteria" id="ADT83040">
        <property type="protein sequence ID" value="ADT83040"/>
        <property type="gene ID" value="TERMP_00062"/>
    </dbReference>
    <dbReference type="GeneID" id="10040381"/>
    <dbReference type="KEGG" id="tba:TERMP_00062"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.62"/>
    <dbReference type="eggNOG" id="arCOG10107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_917090_0_0_2"/>
    <dbReference type="OrthoDB" id="69566at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043765">
        <property type="entry name" value="DUF5711"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18975">
        <property type="entry name" value="DUF5711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="303" mass="35394" checksum="81C29B014D889197" modified="2011-05-03" version="1">MRKIFTFLFLFIVLLLTFYGGYRFLFENRGIAVIPTSITNVSCTIEKFSPPVKIEIEEVKIPVDGGYKPLYTLFKFYDRNGTLVGYWNTTRNFKKGYFYFRDGFVVWSYDGVVEMVYFDYNLTERWWREIYKSVGGYVDFVLYALYADESHIFLLTANRHFATAKVQNYCFYWGSVEEGDIIERFCSDKELSQSSLLGGKVVGNKVYIITDNGLYLFTYKGELIKKKKIELSKIESFDVNEKYLAFVYPSGDKTSKLCVMTSNLKSQRCIDVKGKVEQLRLCENYLLLKIGNKVRVLEIEENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHA2</accession>
    <name>F0LHA2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466362.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00086"/>
    <dbReference type="EnsemblBacteria" id="ADT83064">
        <property type="protein sequence ID" value="ADT83064"/>
        <property type="gene ID" value="TERMP_00086"/>
    </dbReference>
    <dbReference type="GeneID" id="10040405"/>
    <dbReference type="KEGG" id="tba:TERMP_00086"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.86"/>
    <dbReference type="eggNOG" id="arCOG01734">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1536739_0_0_2"/>
    <dbReference type="OMA" id="VYGELIF"/>
    <dbReference type="OrthoDB" id="77507at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="175" mass="20476" checksum="EB45B27A214AA070" modified="2011-05-03" version="1">MEHVIALHQVYGELIFRGLKSHEIRRSRVFNEGDIVFLYIARGNLFTLKRTLEKLGLTEEQLLTKRGTIAGGFEVGEVIKADFETLWELTKDTSGLTFVHGEERGKRWLKEYIKNYGYAFTIEEPFLFKEPISREEMKEKYGVFVEGIIHLSSKTRQPWVRALLEDLMSRETVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHA7</accession>
    <name>F0LHA7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl3</name>
        <name evidence="8" type="ordered locus">TERMP_00091</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466367.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00091"/>
    <dbReference type="EnsemblBacteria" id="ADT83069">
        <property type="protein sequence ID" value="ADT83069"/>
        <property type="gene ID" value="TERMP_00091"/>
    </dbReference>
    <dbReference type="GeneID" id="10040410"/>
    <dbReference type="KEGG" id="tba:TERMP_00091"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.92"/>
    <dbReference type="eggNOG" id="arCOG04070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033361_2_0_2"/>
    <dbReference type="OMA" id="HQRTEYN"/>
    <dbReference type="OrthoDB" id="31722at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_A">
        <property type="entry name" value="Ribosomal_L3_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019928">
        <property type="entry name" value="Ribosomal_L3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="PTHR11363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03626">
        <property type="entry name" value="L3_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="346" mass="38992" checksum="A759DB9C5E3D16CD" modified="2011-05-03" version="1">MGKISKPRRGSLAYSPRKRAKSIVPRIRKWPQEEEVRLLGFAGYKAGMTHILMIDDRPGLTKGKEIFMPVTIVETPPMVVFGIRAYKQGYLGLETATEVWIPNLNPDLKRRIKTLPKNYDEGAFQQKLGELEDLVKSGEIVEVRALVHTQPRLIKLKKKPEVMEYAVGGKSVEDKFAYLKEKLGKEIRAKEVLKEGELLDVIAVTKGKGTQGPVKRWGIKIQFHKAQRAGKGRHVGNLGPWHPARVMWTVPQAGQMGFHHRTEFNKRLIAIGENGFLELNGNKIEITPKGGFPHYGIVRSDFLMIAGSVPGAIKRIVRVRPAIRPPAKKPPVERPQITYVSRESKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHB6</accession>
    <name>F0LHB6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component 1</fullName>
            <shortName evidence="6">RNase P component 1</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rpp29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnp1</name>
        <name evidence="7" type="ordered locus">TERMP_00100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00100"/>
    <dbReference type="EnsemblBacteria" id="ADT83078">
        <property type="protein sequence ID" value="ADT83078"/>
        <property type="gene ID" value="TERMP_00100"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00100"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.101"/>
    <dbReference type="eggNOG" id="arCOG00784">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107020_1_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="SSF101744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="73" mass="8576" checksum="26A38D874C69CF3F" modified="2011-05-03" version="1">MRIRKSSHPELVGIEGYVIDETRNTLTIVGEKVWIIPKNVVEFEFEVGNKKIVIDGKELIGRPEMRLKKRWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHC7</accession>
    <name>F0LHC7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467552.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01279"/>
    <dbReference type="EnsemblBacteria" id="ADT84254">
        <property type="protein sequence ID" value="ADT84254"/>
        <property type="gene ID" value="TERMP_01279"/>
    </dbReference>
    <dbReference type="GeneID" id="10041595"/>
    <dbReference type="KEGG" id="tba:TERMP_01279"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1281"/>
    <dbReference type="eggNOG" id="arCOG10078">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170081_0_0_2"/>
    <dbReference type="OMA" id="GVWAGHE"/>
    <dbReference type="OrthoDB" id="116304at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="108" mass="12008" checksum="3F8147B3E5F32347" modified="2011-05-03" version="1">MKPRPILILFFLLMSIYFYGLGLLSISDKLMFLGFWGIGSIHLLISFGIFLGKDIAITTATYVALLDFLFGLLWGIVGLTLSSFTLAILSALALFLLLDEDVRMNLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHD3</accession>
    <name>F0LHD3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsZ</name>
        <name evidence="9" type="ordered locus">TERMP_01285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467558.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01285"/>
    <dbReference type="EnsemblBacteria" id="ADT84260">
        <property type="protein sequence ID" value="ADT84260"/>
        <property type="gene ID" value="TERMP_01285"/>
    </dbReference>
    <dbReference type="GeneID" id="10041601"/>
    <dbReference type="KEGG" id="tba:TERMP_01285"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1287"/>
    <dbReference type="eggNOG" id="arCOG02201">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_0_1_2"/>
    <dbReference type="OMA" id="RAMVIMT"/>
    <dbReference type="OrthoDB" id="41117at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 6 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="35"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="236"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="410" mass="44684" checksum="8F824E84385BFDE3" modified="2011-05-03" version="1">MVWKLLEQAGINLDFDENTKEKFGEYEENLEGLIKIAIIGVGGSGNNTITRLYELGVQGAELIAMNTDAQHLARTKAHKKILLGKNITHGKGSGGDPRIGYLAAEASAQEIAEVVRDVDLVFITAGMGNGTGTGAAPVVARIIKEVARNNGRYQEPLVVSVVTFPFSTEGTRRIEKAKAGIQALLQYSDTVVIIENDKLLELVPNLPLSAAFRFADEIIARMVKGITETIKLPSIVNIDFADVYSVMKNGGAALIGIGESDSKNRAVDAVVNALNNKMLEVEFGSGEAALIHFTVGPDVKLGEVHEAMKIVYEKLGTKSEIKWGAMIDEDLGKTVRAMVIMTGVNSPHILSGEVNALQDNNRILMPTDTLKMITKDTKLERIFESTMKSEKSKPPVNEDVERIFRDIYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHD9</accession>
    <name>F0LHD9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4443 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01291"/>
    <dbReference type="EnsemblBacteria" id="ADT84266">
        <property type="protein sequence ID" value="ADT84266"/>
        <property type="gene ID" value="TERMP_01291"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01291"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1293"/>
    <dbReference type="eggNOG" id="arCOG02103">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1369596_0_0_2"/>
    <dbReference type="OMA" id="WKRGAYP"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029349">
        <property type="entry name" value="DUF4443"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14544">
        <property type="entry name" value="DUF4443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4443" evidence="5">
        <location>
            <begin position="98"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="217" mass="24698" checksum="4E83D556CDD162B4" modified="2011-05-03" version="1">MIKTFIYQLSETILRGEEMSWKRGAYPEFTLEDAVATLFLLKTPRGRKQISEDLDLGEGSVRTLLKKLAKLELIESKQKGHYLNEKGLNVLFQILTLFSEPAEVEKVENMPTYALIVKNPPQFKSIDLRDEAIRYFAKGAMILVYKAGEIVFPEDERPLKETLPRLAEDLKKLSPKEGDLIVVTWAENRADAIKSAIHVALTLKKNELPKEILEVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHG5</accession>
    <name>F0LHG5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0173 metal-dependent hydrolase TERMP_01317</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0173 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467590.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01317"/>
    <dbReference type="EnsemblBacteria" id="ADT84292">
        <property type="protein sequence ID" value="ADT84292"/>
        <property type="gene ID" value="TERMP_01317"/>
    </dbReference>
    <dbReference type="GeneID" id="10041633"/>
    <dbReference type="KEGG" id="tba:TERMP_01317"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1318"/>
    <dbReference type="eggNOG" id="arCOG00497">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_4_0_2"/>
    <dbReference type="OMA" id="WHGHSTW"/>
    <dbReference type="OrthoDB" id="76909at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00457">
        <property type="entry name" value="UPF0173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022877">
        <property type="entry name" value="UPF0173"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="225" mass="24600" checksum="808647B48AC8E1B3" modified="2011-05-03" version="1">MVKIRFLGHAAFEIEGSKRILIDPFLTGNPVAATKPEDFDKVDLILVTHMHGDHVGDAVKIAQKTGAKIVAMYDIANYLVERNKGITTIGMNYGPTEIDGVKIVQVPAWHSSGADEGFMVGNACGFIIGIDGVTIYHAGDTYVFKDMELFGELYGIDVALLPIGGHFTMGPKEAAKAVELLKPKYVIPMHYNTWPPIAQDPEEFKKLVGDKAEVIILKPGETFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHI0</accession>
    <name>F0LHI0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467605.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01332"/>
    <dbReference type="EnsemblBacteria" id="ADT84307">
        <property type="protein sequence ID" value="ADT84307"/>
        <property type="gene ID" value="TERMP_01332"/>
    </dbReference>
    <dbReference type="GeneID" id="10041648"/>
    <dbReference type="KEGG" id="tba:TERMP_01332"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1332"/>
    <dbReference type="eggNOG" id="arCOG00349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_6_4_2"/>
    <dbReference type="OMA" id="ICAAMEP"/>
    <dbReference type="OrthoDB" id="111853at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="68" mass="7750" checksum="7AE6C3D0B5F8391D" modified="2011-05-03" version="1">MSRWKVWIDRELCVGDAVCVSFCPEVFQLDEDGKAIVLKEIIDENLYDCVKEAVDACTAACIYMEQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHM0</accession>
    <name>F0LHM0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83104">
        <property type="protein sequence ID" value="ADT83104"/>
        <property type="gene ID" value="TERMP_00126"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00126"/>
    <dbReference type="HOGENOM" id="CLU_3210928_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="44" mass="5063" checksum="2C724BDB986D5E1F" modified="2011-05-03" version="1">MLCNSGKKLMITPIYEGEIFERHEVITLSMSGFNYIQCGQSYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHM3</accession>
    <name>F0LHM3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps11</name>
        <name evidence="7" type="ordered locus">TERMP_00130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located on the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466405.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00130"/>
    <dbReference type="EnsemblBacteria" id="ADT83107">
        <property type="protein sequence ID" value="ADT83107"/>
        <property type="gene ID" value="TERMP_00130"/>
    </dbReference>
    <dbReference type="GeneID" id="26135445"/>
    <dbReference type="KEGG" id="tba:TERMP_00130"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.131"/>
    <dbReference type="eggNOG" id="arCOG04240">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_6_1_2"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="OrthoDB" id="114285at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019961">
        <property type="entry name" value="Ribosomal_S11_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03628">
        <property type="entry name" value="arch_S11P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="136" mass="14547" checksum="552044B4950091C5" modified="2011-05-03" version="1">MSEEVNIKKKEKWGVAHIYSSYNNTIIHITDLTGAETISRWSGGMVVKADRDEPSPYAAMIAAKRAAEEALEKGIVGVHIKVRAPGGSKSKTPGPGAQAAIRALARAGLKIGRVEDVTPIPHDGTRPKGGRRGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHN3</accession>
    <name>F0LHN3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466415.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00140"/>
    <dbReference type="EnsemblBacteria" id="ADT83117">
        <property type="protein sequence ID" value="ADT83117"/>
        <property type="gene ID" value="TERMP_00140"/>
    </dbReference>
    <dbReference type="GeneID" id="10040458"/>
    <dbReference type="KEGG" id="tba:TERMP_00140"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.141"/>
    <dbReference type="HOGENOM" id="CLU_1736506_0_0_2"/>
    <dbReference type="OrthoDB" id="127640at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="150" mass="16588" checksum="1C12C1D4F8364888" modified="2011-05-03" version="1">MAVDGMTQKLLKGVGFLLFILAVIYLLEFLLNMDTPYFNDSDAVELILKSAVYFFLVGGMLILFAVAYSEINNSCVKALGGTVLLGLAALPGYSVSVKYLTRKCCSSCSTFKMHWIVDVIGLFIFTFAVGGIILLWFQYLRVLCEQPKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHP7</accession>
    <name>F0LHP7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00154"/>
    <dbReference type="EnsemblBacteria" id="ADT83131">
        <property type="protein sequence ID" value="ADT83131"/>
        <property type="gene ID" value="TERMP_00154"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00154"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.155"/>
    <dbReference type="HOGENOM" id="CLU_1088282_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="255" mass="29404" checksum="5A1C1824D99C3A24" modified="2011-05-03" version="1">MYSAKLEGYAYPPDFWRGNPILIQRTTTSKGSNMSVLLFNGSALLKIHTWDECSMLYPVPVGGRIFTLCLSKSKAKYTSNILELFEVKNKNKKAELLNIFRTKGYIYVYDVDDFKGFPAFKLWKHSSLIIYTNESIFLFNSTHVLNLLTNERIELSEGLKNMEYYVAYCCNGWILFTKSGAYSLKNDKFENLTPKLITFLENVSLDYSKESVKLPSTLENIKNGSIFFPINKIFTVIIIGITTVLIIMILRRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHT2</accession>
    <name>F0LHT2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ni-Fe hydrogenase metallocenter assembly HypE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467630.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01357"/>
    <dbReference type="EnsemblBacteria" id="ADT84332">
        <property type="protein sequence ID" value="ADT84332"/>
        <property type="gene ID" value="TERMP_01357"/>
    </dbReference>
    <dbReference type="GeneID" id="10041673"/>
    <dbReference type="KEGG" id="tba:TERMP_01357"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1357"/>
    <dbReference type="eggNOG" id="arCOG00636">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049733_0_0_2"/>
    <dbReference type="OMA" id="CGNGGKE"/>
    <dbReference type="OrthoDB" id="34102at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02197">
        <property type="entry name" value="HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02124">
        <property type="entry name" value="hypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="40"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="161"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="336" mass="35678" checksum="987AB811D263FDAE" modified="2011-05-03" version="1">MKIKLEYGAGGELMEEFIKEFILKNLSLKSAGGVGLEALDDGATIPFGDKHIVFTIDGHTVKPLFFPGGDIGRLAVSGTVNDLAVMGAKPLALANSMIIQEGFDSGDFERILQSMDETAKEVPVPIVTGDTKVVEDKIGIFVITAGLGVAERVITDSGANTGDVVLVSGTVGDHGIAIMSHREGIAFETELKSDVAPIWEVVKAVADAIGWENIHAMKDPTRGGLSNALNEIARKSNVGILVRESDIPVKPEVRAASDMLGISPYEVANEGKVVMVVAREYAEEALEAMRKTKRGKDAAIIGEVIGEYKGKVILETGIGGKRFMEPPIGDPVPRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHW3</accession>
    <name>F0LHW3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lead/cadmium/zinc and mercury transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01388"/>
    <dbReference type="EnsemblBacteria" id="ADT84363">
        <property type="protein sequence ID" value="ADT84363"/>
        <property type="gene ID" value="TERMP_01388"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01388"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1388"/>
    <dbReference type="eggNOG" id="arCOG01576">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_11_2_2"/>
    <dbReference type="OMA" id="ACGMNMV"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="724" mass="79779" checksum="E01C5215FE8DE953" modified="2011-05-03" version="1">MDEKKMVHGEHVHDEAERAPEMKDMEHAHESEHREHGTEHKMHEGHEMATHKEHTGHEEHEHIHEEHAGHEGHKHSHAEHHRMMMEDFKKRFIISAILTIPILFLSPLIQRFLGFTFTFRGDHYVLFALSAIVYFYGGWPFLNGMIEEFKKKLPGMMTLIALAITVAFSYSVAVTFGLPGKTFYWELATLIDIMLLGHYIEMRSVLGASRALEELIKLMPTEAHLVTPEGIKDVPVSELKKGDIVLVKPGEKIPSDGIIIEGETSVNEAMLTGESKPVYKKPGDTVIGGSINLEGAIKVRIEKTGKDTYLMQVVELVRQAQETRSRTQDLANRAAFYLTLIAITAGTITLGTWLYLGKPFVFALERMVTVMVITCPHALGLAVPLVVSVSTSISAKKGILIRNREAFERAKDVQVVVFDKTGTLTEGKFEVTDIIALDELGEEEILKYAAALESHSSHPIAQGIVEKAKELGLEVYEVSESKVLPGKGVKGVINGKEVLVVSPGFLKENGLWREDERVNKVLEQGKTVVFLVLDGKLVGALALADKIRPESREAVKKLHEMGIKAYMLTGDNAKVAKWVAEELGLDGFFAEVLPHQKSEKIKELQEQGYTVAMVGDGINDAPALIQADVGIAIGAGTDVAIESADIILVKNDPRDVITAIHLARATYKKMVQNLAWATGYNTFAIPLAAGVLYNYGVLLSPAVGALLMSLSTVIVAINAKFLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHX0</accession>
    <name>F0LHX0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467668.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01395"/>
    <dbReference type="EnsemblBacteria" id="ADT84370">
        <property type="protein sequence ID" value="ADT84370"/>
        <property type="gene ID" value="TERMP_01395"/>
    </dbReference>
    <dbReference type="GeneID" id="10041711"/>
    <dbReference type="KEGG" id="tba:TERMP_01395"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1395"/>
    <dbReference type="eggNOG" id="arCOG09747">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1369593_0_0_2"/>
    <dbReference type="OMA" id="LNRVFEM"/>
    <dbReference type="OrthoDB" id="85299at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="198" mass="23475" checksum="C40842E498F5E91C" modified="2011-05-03" version="1">MGILDRFRKNPIEKLSLRELQEEEIRLRNRLERTKKEIERIEKKKKQLFQEGIGADVLKKKMLAQEIKSLDMEQKLRLRDFTTAQKQYTFVKNLIVVKKYEKELRKIGLWDKLSKVEPEQLESVLVKVSLDGREFDEMVENLNRVFEMDIAEFEGTEDQTERELMDAWAKVETGEADVEEVTEKIASPKLERETEEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHX2</accession>
    <name>F0LHX2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467670.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01397"/>
    <dbReference type="EnsemblBacteria" id="ADT84372">
        <property type="protein sequence ID" value="ADT84372"/>
        <property type="gene ID" value="TERMP_01397"/>
    </dbReference>
    <dbReference type="GeneID" id="10041713"/>
    <dbReference type="KEGG" id="tba:TERMP_01397"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1397"/>
    <dbReference type="eggNOG" id="arCOG08177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128028_0_0_2"/>
    <dbReference type="OMA" id="QVEINSE"/>
    <dbReference type="OrthoDB" id="79095at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="172" mass="19805" checksum="0421B6DC4135F4B8" modified="2011-05-03" version="1">MPHLFIVCYENDAERKRVEYLLDKWSNRARISKVRGISFIIDSSDVEGFAEELLSKLDPPTEGKVMVYRVEPEDIGSRVSPTRREIKHLTWEEPVVVRKLLKYVLSKFGAYYVSSEGNVSRYRAYTKKGRMEVEVLVEERDNGTAVVIAIEGYGTAVDDMARKLERELSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI24</accession>
    <name>F0LI24_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83178">
        <property type="protein sequence ID" value="ADT83178"/>
        <property type="gene ID" value="TERMP_00201"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00201"/>
    <dbReference type="HOGENOM" id="CLU_3245540_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="42" mass="5052" checksum="ACD5FEE01D2048AA" modified="2011-05-03" version="1">MIPFCHADCYFMHDKKLSEWIFKNCPKIKIEKLRSKGNILKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI48</accession>
    <name>F0LI48_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00225"/>
    <dbReference type="EnsemblBacteria" id="ADT83202">
        <property type="protein sequence ID" value="ADT83202"/>
        <property type="gene ID" value="TERMP_00225"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00225"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.225"/>
    <dbReference type="eggNOG" id="arCOG01201">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02123">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1131646_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="2">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="136"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="226" mass="25768" checksum="CC8758A4F0EB54B5" modified="2011-05-03" version="1">MSISEEIKLHIKLAEEELAPANALLELGYYRDAISRAYYSMFHAAKALLLTKGINPKKHSGVVKMFGLHFVTEGFVEETYAKAFNRAFALRSRADYDIYYSPANEEAREIVESAEAFLERVKSALEMISDEEKALEAFLEELKGKFGDRIEEIIIFGSYVRGDYDEESDIDVMIVGNVSFDEIINISTKVLLKYGELISPIIISPEEFRRRNDSFIKTVKREGIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="ADT83205">
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    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00228"/>
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    <dbReference type="Proteomes" id="UP000007478">
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    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="417" mass="46444" checksum="7E6EB03236A49E97" modified="2011-05-03" version="1">MNSTMLQYDVVVIGGGPAGLAAAVKAKEYGLNVLLLDENDYLGGILPQCIHPGFGIHYFREELTGPEFSHRFVQRVKDLKIDYFVKARVLEIKNYSDLEKVVVFTSPKGVFEVWTKAIIYATGARERHAFEIGIVGDRVAGIYTAGEAQTLMDIYGVMPGKEVVIVGSGDVGLIMARRFALEGAKVKAVIELMPYPGGLARNVMILRDFNIPLYLSHKVVEVRGKKRVEKVKIMKVDENLREIPGTEFWIDCDTVVISAGLIPQVKLLTEIGVEIDPTTGGPVVNDLLETTVPGIFVAGNSLLINDLVDYVAEQGELAAYGAKLFIENRGIPAEKWIKLEKGNNVRLAVPHYLSGKRDVYIYARVRKPMENVVLNFPEIDKKIRLPVVRPAEMLRIRLRKEEIAKAKDKITMEVVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI71</accession>
    <name>F0LI71_THEBM</name>
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        <submittedName>
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        </submittedName>
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    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="391623"/>
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            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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    <dbReference type="EnsemblBacteria" id="ADT83225">
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    </dbReference>
    <dbReference type="GeneID" id="10040566"/>
    <dbReference type="KEGG" id="tba:TERMP_00248"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.248"/>
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    <dbReference type="OMA" id="ENGYYDR"/>
    <dbReference type="OrthoDB" id="12142at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="373" mass="42604" checksum="15FAD313B43217D7" modified="2011-05-03" version="1">MREKLALISLDGNGVYNLKHMPFLRSLIEEGSFEVVDSIFPTLTDLVHTSVMTGVYPKDHGVVENGYYDRLSDRKINFYDYEVAFNPHKVIKARTIVDILREKGIRSASVSGYTMPPFSGTNVRIFPPFFSDDKLYRQHGRDWRKDVWVAQSALYLYEECKPDLLLVHFCSIDGMQHDYGIKSEEALKAVKTVDEMLKLIWKRLKDEYAFIIFADHGQENVHTWVNLKTYLKKHGIETLRVSSGGGVHIYLKDPNQAEEAYQVLLKAPGVKHVFFRDDLPHLNTPNSGELMVSAKEGYWFCSHAKCKGIKGTSYWVKGMHGSMNEQVVKVPLILWGFENVNIENACLMDIAPTVLTFFGIEKPKEMVGKSLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI77</accession>
    <name>F0LI77_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="ADT83231">
        <property type="protein sequence ID" value="ADT83231"/>
        <property type="gene ID" value="TERMP_00254"/>
    </dbReference>
    <dbReference type="GeneID" id="26135597"/>
    <dbReference type="KEGG" id="tba:TERMP_00254"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.254"/>
    <dbReference type="eggNOG" id="arCOG05879">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2766304_0_0_2"/>
    <dbReference type="OMA" id="HYDDVWH"/>
    <dbReference type="OrthoDB" id="122330at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="69" mass="7917" checksum="47CE98F2AB9FCC57" modified="2011-05-03" version="1">MTAIIKKDVNKFVKELKKHYSDVWKIPSSRYLDNPDFIVVDPRTGKKVKISFVALDDGETVSIVYDDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI92</accession>
    <name>F0LI92_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01447</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
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            <taxon>Thermococcus</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84422">
        <property type="protein sequence ID" value="ADT84422"/>
        <property type="gene ID" value="TERMP_01447"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01447"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1447"/>
    <dbReference type="HOGENOM" id="CLU_3283048_0_0_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="40" mass="4497" checksum="92B9DD8028E12C90" modified="2011-05-03" version="1">MEDFLTGLHVLAPLLGLFVFIAFAGFIVWAGWKLVKMMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI99</accession>
    <name>F0LI99_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84429">
        <property type="protein sequence ID" value="ADT84429"/>
        <property type="gene ID" value="TERMP_01454"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01454"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1454"/>
    <dbReference type="HOGENOM" id="CLU_3302928_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="39" mass="4938" checksum="3A60216145547669" modified="2011-05-03" version="1">MHKEKPKIEQPKEERKKEKDPFEWKSIWDEESALFEEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIA6</accession>
    <name>F0LIA6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467734.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01461"/>
    <dbReference type="EnsemblBacteria" id="ADT84436">
        <property type="protein sequence ID" value="ADT84436"/>
        <property type="gene ID" value="TERMP_01461"/>
    </dbReference>
    <dbReference type="GeneID" id="26136951"/>
    <dbReference type="KEGG" id="tba:TERMP_01461"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1461"/>
    <dbReference type="eggNOG" id="arCOG11048">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184958_0_0_2"/>
    <dbReference type="OMA" id="WIERDIS"/>
    <dbReference type="OrthoDB" id="129712at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="86" mass="9599" checksum="6478D4CDB2527EC6" modified="2011-05-03" version="1">MIDIILDVAIIGIALFLSFVSWIAYKKSGMKSILFLLLAFLLFGIKKTLENLHIIAGIKESTLDIVATVLELMILLLFFIAVVKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIH4</accession>
    <name>F0LIH4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L40e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl40e</name>
        <name evidence="5" type="ordered locus">TERMP_00271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466546.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00271"/>
    <dbReference type="EnsemblBacteria" id="ADT83248">
        <property type="protein sequence ID" value="ADT83248"/>
        <property type="gene ID" value="TERMP_00271"/>
    </dbReference>
    <dbReference type="GeneID" id="26135612"/>
    <dbReference type="KEGG" id="tba:TERMP_00271"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.271"/>
    <dbReference type="eggNOG" id="arCOG04049">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_205640_0_0_2"/>
    <dbReference type="OMA" id="MRCGATN"/>
    <dbReference type="OrthoDB" id="127293at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00788">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="L40e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_L40e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023657">
        <property type="entry name" value="Ribosomal_L40e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39649">
        <property type="entry name" value="PTHR39649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L40e" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="52" mass="5974" checksum="889B8A7AACCA28AA" modified="2011-05-03" version="1">MARFPEAEARIFKKYICMRCGATNPWKAEKCRKCGYKGLRPKAREPRGGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIH6</accession>
    <name>F0LIH6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00273"/>
    <dbReference type="EnsemblBacteria" id="ADT83250">
        <property type="protein sequence ID" value="ADT83250"/>
        <property type="gene ID" value="TERMP_00273"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00273"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.273"/>
    <dbReference type="eggNOG" id="arCOG01131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_2_2"/>
    <dbReference type="OMA" id="WRMGWII"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="47"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="414" mass="46822" checksum="C1CE6307F129D0C7" modified="2011-05-03" version="1">MIECSTNYESSLLVIEMIHASKRAMGIEYAIRDVVLPARELEKQGIKIIKLNIGDPVKFDFQPPKHMKEAYCRAIMEGHNYYGESEGDIELRKAIVEREKKKNGVDITVDDVMVTAAVTEALQFVFGALVEPGDEVLIPGPSYPPYVALVKFYDGVPKAYLGIEEEGWQPDIDDMRKKISEKTKAIAVINPNNPTGALYDKKTLKEILDLAGEYDIPVISDEIYDLMTYEGKHVSPGSLTKDVPVIVMNGLSKVYFATGWRLGYMYFVDPEDKLAEVREAIGKLARVRLCPNTPAQKAAIAGLTGPMDYLEGYMKKLKERRDYIYKRLNEIPGLSAQKPEGAFYIFPRIEERSKWKSDKEFVLDVLRNAHILVVHGSGFGEGGEWHFRAVFLPPVEILEQAMDNLEKFMKERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIH9</accession>
    <name>F0LIH9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466551.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00276"/>
    <dbReference type="EnsemblBacteria" id="ADT83253">
        <property type="protein sequence ID" value="ADT83253"/>
        <property type="gene ID" value="TERMP_00276"/>
    </dbReference>
    <dbReference type="GeneID" id="10040594"/>
    <dbReference type="KEGG" id="tba:TERMP_00276"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.276"/>
    <dbReference type="eggNOG" id="arCOG07159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_3_2"/>
    <dbReference type="OMA" id="DIQACLF"/>
    <dbReference type="OrthoDB" id="102938at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="236" mass="26865" checksum="F1E49AD121C932E6" modified="2011-05-03" version="1">MKAAIIWDFDGVLVFTPHEEAWKKAAEHYGVKDFDHDFFINYVSGKPRYEGADNILRLKGIYKRLGARTEEEKQKILQEFAEFKNKLVNEMFDRGEYGINNEAIKFLIETKGVGVKHALASASKNAPKLAQKIKIYVNGEEKTLLDLFDVNVSGLAPTKKAVFELAIKELKSKFPELGVFIVIEDSPTGVEVAKELGIFTLGYEREAKLDADLTFKDFREISWEKILDRLKRRSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIK3</accession>
    <name>F0LIK3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">50S ribosomal protein L37e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpl37e</name>
        <name evidence="12" type="ordered locus">TERMP_00300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10 11">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 11">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466575.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00300"/>
    <dbReference type="EnsemblBacteria" id="ADT83277">
        <property type="protein sequence ID" value="ADT83277"/>
        <property type="gene ID" value="TERMP_00300"/>
    </dbReference>
    <dbReference type="GeneID" id="26135641"/>
    <dbReference type="KEGG" id="tba:TERMP_00300"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.300"/>
    <dbReference type="eggNOG" id="arCOG04126">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208825_0_0_2"/>
    <dbReference type="OMA" id="RIRRYSW"/>
    <dbReference type="OrthoDB" id="124429at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_L37e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 10 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT83277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="62" mass="7293" checksum="4F944E7712D93C33" modified="2011-05-03" version="1">MGSGTAPHGKRNRTPTHIKCRRCGRKAYNVRKRYCAACGFGRSRRLRKYSWSKKWKKAKNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIP0</accession>
    <name>F0LIP0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptide-binding ABC transporter periplasmic substrate-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467790.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01517"/>
    <dbReference type="EnsemblBacteria" id="ADT84492">
        <property type="protein sequence ID" value="ADT84492"/>
        <property type="gene ID" value="TERMP_01517"/>
    </dbReference>
    <dbReference type="GeneID" id="10041833"/>
    <dbReference type="KEGG" id="tba:TERMP_01517"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1517"/>
    <dbReference type="eggNOG" id="arCOG01533">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_390634_0_0_2"/>
    <dbReference type="OMA" id="MEEGQGF"/>
    <dbReference type="OrthoDB" id="6658at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="273"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="725" mass="81811" checksum="818BEB24CFC5F9E3" modified="2011-05-03" version="1">MKKALSALFLIAILGFAVVASGCIGGEKTTTPTSTQATTQTTTQTSTASSPTKTTTQTQAPKPKGITPAILELDKVAVIETDKSVIVVGPKGENPTVSLPSGKKVIRVSYVVDEANTPDIKKLMEEGQGFGAIDPAFFRNTNVDALVIAARRQTDPAIRTELFKALYILGNYYVPEVIIGQNRQLRVYWSWVKGRYYHPTLPERYDLLWEDPNAPSVSIGIGEYKNDAETYVIGTIGWPESFDPAWTYETFGWEIWHEIGDTLVTYWKDETEEVSPDLAVAWAHNEDGTEWYFVIRGGVKAYDPWNDKTYPIDATDVAFTFWRVQRLGHSVSWMVSEFMDVNKSQALTEQDFENILKSEKLIAEYKGKTVEVKSLDDLLKLFGYSGKTAGVFKLVLPHPYAPVLNILADPFLSVVPMEYLLGDKYEEALKASDNGKNPSAWAKYVQEGEQDPTHQLMHKKPVGTGPYYVKEYQENSYIVLELNPYYWNKDIWNNIKPLHKRVIYVINNDAVSRIQLFQTGTVDTVATPPERINDVKGLKLDGFESIVQTDLLQPILTFIVFNTYKEPFNNVKVRQALAYAIPYDQIAQTVYSGLLERNWGPIPKPWPGYTEQGIIKYDYNLAKAQQLLKESGIDPTKYKIELIYNAGNSAREKIMTLLQNVWSQLGFQVTVASYEWPVYLGKVSKGDFDVYVVGWVPDYLDSDNWVGPFLYGATKFKELNVEVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIR1</accession>
    <name>F0LIR1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467811.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01538"/>
    <dbReference type="EnsemblBacteria" id="ADT84513">
        <property type="protein sequence ID" value="ADT84513"/>
        <property type="gene ID" value="TERMP_01538"/>
    </dbReference>
    <dbReference type="GeneID" id="10041854"/>
    <dbReference type="KEGG" id="tba:TERMP_01538"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1538"/>
    <dbReference type="eggNOG" id="arCOG00915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_2"/>
    <dbReference type="OMA" id="DVFPRFA"/>
    <dbReference type="OrthoDB" id="20774at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="445" mass="49652" checksum="26DE0ADE7BCE2CCC" modified="2011-05-03" version="1">MVKRPVVKELPGPKAKEVIERNFELLAVTTQDPDALPIVIERGEGIMVYDVDGNAFYDFGSGVGVLNVGHVHPRVIEAIKRQAEKFTHFALNDFFYENAVILAQKLAELSPGDFPKKVVYQNSGAEANEVMMKLVKYGTGRKRFIAFYHAFHGRTQAVLSLTASKWVQQERFFPTMPGVEHVPYPNPYRNPWHIDGYADPKELVNRVIEFIEEYVFRHVPPEEVGAIVFEPIQGEGGYVVPPKEFFKELKKLADKYGILLADDEVQMGVGRTGKFWAIEHFGIAPDTIQFGKAIGGGIPLAGVVHRADIAFDKPGRHASTFGGNPVAIAAALEVVEIVKELLPHVQEVGDYLHKRLKEFEEKYEVIGDARGLGLAQAVEFVKNKDTKEKNPEVRNKVVKEAAKRGLILLGCGDNSLRFIPPLIVTKEEIDIAMEIFEEALKAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIR4</accession>
    <name>F0LIR4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="4">DERA</shortName>
            <ecNumber evidence="4">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="4">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">deoC</name>
        <name evidence="5" type="ordered locus">TERMP_01541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467814.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01541"/>
    <dbReference type="EnsemblBacteria" id="ADT84516">
        <property type="protein sequence ID" value="ADT84516"/>
        <property type="gene ID" value="TERMP_01541"/>
    </dbReference>
    <dbReference type="GeneID" id="26137053"/>
    <dbReference type="KEGG" id="tba:TERMP_01541"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1541"/>
    <dbReference type="eggNOG" id="arCOG04320">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_1_2"/>
    <dbReference type="OMA" id="MNACIPP"/>
    <dbReference type="OrthoDB" id="74992at2157"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="4">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="220" mass="23915" checksum="39B67228EB892597" modified="2011-05-03" version="1">MEIDIAKYIDHTNLKPYATKEDIIRLCEEAKKYGFYAVCVNPYRVKLAKETLKGTDIKVASVIGFPLGATPTEVKVFEAKKALEDGADELDMVINIGALKDGDYDYVRKDIEEVVKVAHEKGAIVKVIIETCYLTDEEKEIACKLAMEAGADFVKTSTGFGTGGATVEDVKLMRRVVGDKLGVKAAGGIRTYEQALEMIKAGANRIGTSSGVKIVEGAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIT2</accession>
    <name>F0LIT2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketoisovalerate oxidoreductase VorD-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotetramer of one alpha, one beta, one delta and one gamma chain.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467832.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01559"/>
    <dbReference type="EnsemblBacteria" id="ADT84534">
        <property type="protein sequence ID" value="ADT84534"/>
        <property type="gene ID" value="TERMP_01559"/>
    </dbReference>
    <dbReference type="GeneID" id="26137243"/>
    <dbReference type="KEGG" id="tba:TERMP_01559"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1559"/>
    <dbReference type="eggNOG" id="arCOG01605">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_1_1_2"/>
    <dbReference type="OMA" id="LYCPESV"/>
    <dbReference type="OrthoDB" id="125632at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011898">
        <property type="entry name" value="PorD_KorD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43724">
        <property type="entry name" value="PTHR43724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02179">
        <property type="entry name" value="PorD_KorD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="105" mass="12010" checksum="47C2E6FB11A2B3A2" modified="2011-05-03" version="1">MNTLFGEKKAKAERLVFKSVDEYPEVPLTLGTTLVNFTGDWRTFIPVIDESKCIKCYICWKFCPEPSIYIKEDGYVAVDYDYCKGCGICANECPTKAITMVREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ12</accession>
    <name>F0LJ12_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="1">TMP kinase</shortName>
            <shortName evidence="1">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="1">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiL</name>
        <name evidence="4" type="ordered locus">TERMP_00381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466656.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00381"/>
    <dbReference type="EnsemblBacteria" id="ADT83358">
        <property type="protein sequence ID" value="ADT83358"/>
        <property type="gene ID" value="TERMP_00381"/>
    </dbReference>
    <dbReference type="GeneID" id="10040699"/>
    <dbReference type="KEGG" id="tba:TERMP_00381"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.381"/>
    <dbReference type="eggNOG" id="arCOG00638">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046964_2_0_2"/>
    <dbReference type="OMA" id="HFRRDWS"/>
    <dbReference type="OrthoDB" id="104636at2157"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="23"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="143"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="311" mass="34433" checksum="D4A7290538A332EA" modified="2011-05-03" version="1">MEREIIKVFMRHFKLQGDLPLGDDAGAVKIGREWLVATNDMLVKTTDVPEIMTPEQVGFKAVTMNVSDLAAMGAKPMGFLFSLGIPKNPDMKYLEGIAKGIARASEFYKIPIISADTNEACDLIIDGIALGKTERLLLRSNSKPGDLVCVTGDVGRALAGLKVYFGKLEIEERIQKALYEKLLEPNARINEGIALSRYANATIDISDGMSKELHLIAEMSNVKIVIESEKLPIRGEVFEVAEILGLDPIEIALASGEEFELIFTIPEEHLNKLNFDFTVIGKVEKGEGVYLKREDKLEKMPILGWEHLTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ20</accession>
    <name>F0LJ20_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466664.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83366">
        <property type="protein sequence ID" value="ADT83366"/>
        <property type="gene ID" value="TERMP_00389"/>
    </dbReference>
    <dbReference type="GeneID" id="10040707"/>
    <dbReference type="KEGG" id="tba:TERMP_00389"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.389"/>
    <dbReference type="eggNOG" id="arCOG05780">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1248337_0_0_2"/>
    <dbReference type="OMA" id="FKRYYYW"/>
    <dbReference type="OrthoDB" id="78476at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="221" mass="24489" checksum="3D17E6CD450A56A7" modified="2011-05-03" version="1">MNKRLLALVLTIILIVVPLAVAFYGYNNYTKVIEPQRKPLAVKPVAVPFEGRTYPILLESYITGDPLVDINMTLRSPYERATIILGDPSFKDCKGSEACIWRVRTVSELGATIGAVFGVKYYVEDIMKSGSNKTAAYKAAKETTERIDNRYLAFIPKAEIGLGLIGNKKHLLVILKGPREGAEKNRIYCPKPGILVIEGTTEDTLFVEVLLIKTIISSQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ54</accession>
    <name>F0LJ54_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01601"/>
    <dbReference type="EnsemblBacteria" id="ADT84576">
        <property type="protein sequence ID" value="ADT84576"/>
        <property type="gene ID" value="TERMP_01601"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01601"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1601"/>
    <dbReference type="eggNOG" id="arCOG01880">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1381481_0_0_2"/>
    <dbReference type="OMA" id="VSTFGDC"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="PTHR31303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="230" mass="26061" checksum="06EE42DC7EEDB706" modified="2011-05-03" version="1">MEARFMPLKFKSKVFSKIESRIGRRELVRKLWHISPGILGAPIILFTPKYITLFVVWFLAFIYTLQHLKLRKGWKIKVPIAEISYRQMARKDELEGNHYMGSFLFWVTMGMICTVFPKLIALAALWVSTFGDCFNAIVGQAVGGVRIPWNKNKTVIGSLTMFVVSIFALITAHKVVGASYGLGLLAFVASVATFMESLPIYSAWDEFTVPMSTAILLWLFYGGELLSTMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJA1</accession>
    <name>F0LJA1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467921.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01648"/>
    <dbReference type="EnsemblBacteria" id="ADT84623">
        <property type="protein sequence ID" value="ADT84623"/>
        <property type="gene ID" value="TERMP_01648"/>
    </dbReference>
    <dbReference type="GeneID" id="26137155"/>
    <dbReference type="KEGG" id="tba:TERMP_01648"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1647"/>
    <dbReference type="eggNOG" id="arCOG05743">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2476158_0_0_2"/>
    <dbReference type="OMA" id="HTSWEFT"/>
    <dbReference type="OrthoDB" id="128662at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="95" mass="11412" checksum="39E211841968D169" modified="2011-05-03" version="1">MRVKDLLELLEEAIANVKVAIVVSKQRIFESPHTSWEFTQRSLELEDELDRLNKIKDYLLKFDPDENVEKIFSEEELNELLEYLTALREMKEHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJA5</accession>
    <name>F0LJA5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467925.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01652"/>
    <dbReference type="EnsemblBacteria" id="ADT84627">
        <property type="protein sequence ID" value="ADT84627"/>
        <property type="gene ID" value="TERMP_01652"/>
    </dbReference>
    <dbReference type="GeneID" id="26137150"/>
    <dbReference type="KEGG" id="tba:TERMP_01652"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1651"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062979_2_0_2"/>
    <dbReference type="OMA" id="GGAPWLM"/>
    <dbReference type="OrthoDB" id="65016at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="3">
        <location>
            <begin position="112"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="340" mass="39515" checksum="E1BB907E41FCE334" modified="2011-05-03" version="1">MKEEEIIEKLQKLGLTKYESLAYITLLKLGPSKATDITKESGIPHTRVYDVLSSLHRKGFVDIMHGTPRLYKPVNPEVVLEKIKEDLIADIEELKKAFLKLYRSVHGEDLPEIWTIHGFDNTLERAEYIIRTAKYEVLINTPFEFLSLLKEEIKKRKDVVFVIISNFEEIPEWLKRDNIILARSGGAPWLMASWIIGDIDYALFFGALPRDRRKEKFYSFWAKSAKLIQNYMHWFYTIYLDNSTIIKPVNYDKLKKPLQLVNIRTLITLLKQTSLPREIEVIGKLVENKDTITLRGKVIEFEYTPLIASVVVDDGNKKWKVGGLGSYFEDVEGEKFILLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJA9</accession>
    <name>F0LJA9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Maltose/maltodextrin ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467929.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01656"/>
    <dbReference type="EnsemblBacteria" id="ADT84631">
        <property type="protein sequence ID" value="ADT84631"/>
        <property type="gene ID" value="TERMP_01656"/>
    </dbReference>
    <dbReference type="GeneID" id="10041972"/>
    <dbReference type="KEGG" id="tba:TERMP_01656"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1655"/>
    <dbReference type="eggNOG" id="arCOG00160">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_2"/>
    <dbReference type="OMA" id="FIGGWTE"/>
    <dbReference type="OrthoDB" id="90707at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="209"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="419" mass="45791" checksum="AC3733B7CCDB9D83" modified="2011-05-03" version="1">MNIRLPKRRGEVIKAFAVTLVAILIMFIILFPVYYIFTVSIKPVSTLATTELTLIPKNITAEAYKEVLFGFEGSKISANFTGKIEGNGKLDGNILYVTNGRIIGTVKAGPFTALRFEIPFKEVKFRVGQSGSKEGPFNGEISGAFRLTRINKDGSIGFAVVKNVKLENGRINGITVSGTMEKYIVARNTGAVEITAVGKFVNSVFFGHLKNSLFIAGFTVILTLFFVIPAAYAFSRLKFFGREHVLYFYLMFTQVAGGLGIAGLIALYGMIVKLGLYDKLPVLSLIYAAGSVPFNTWLLKGYIDSISPDFDEAALVDGASYLQIIRYVLLPMALPGIATVAIFAFIGGWTEFILANLLLTEANQPLSVWIYLLMGGIGRGIDWNYFAAAALLFALPVFIMFMLAQNYVRSGLTVGGLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJB2</accession>
    <name>F0LJB2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0146 protein TERMP_01659</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0146 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467932.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01659"/>
    <dbReference type="EnsemblBacteria" id="ADT84634">
        <property type="protein sequence ID" value="ADT84634"/>
        <property type="gene ID" value="TERMP_01659"/>
    </dbReference>
    <dbReference type="GeneID" id="10041975"/>
    <dbReference type="KEGG" id="tba:TERMP_01659"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1658"/>
    <dbReference type="eggNOG" id="arCOG04385">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148458_0_0_2"/>
    <dbReference type="OMA" id="LIYSIRP"/>
    <dbReference type="OrthoDB" id="92832at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00341">
        <property type="entry name" value="UPF0146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005353">
        <property type="entry name" value="UPF0146"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03686">
        <property type="entry name" value="UPF0146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="135" mass="15723" checksum="03151382012D3C3C" modified="2011-05-03" version="1">MYEKLAEYFAQKFKRGKIIEIGIGFNFKAALKLKEMGFDVVVIDWNPKAVERAKEIGLNAIVDDIFNPRLEIYKQAKAMYSIRPTPEMMPYLLKLAKTIKVPLYIVPFSTDAVPIEMRLENYRGLVIYKWEAKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJG0</accession>
    <name>F0LJG0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LacZ expression regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00449"/>
    <dbReference type="EnsemblBacteria" id="ADT83426">
        <property type="protein sequence ID" value="ADT83426"/>
        <property type="gene ID" value="TERMP_00449"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00449"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.449"/>
    <dbReference type="eggNOG" id="arCOG01153">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_540399_0_0_2"/>
    <dbReference type="OMA" id="CGHKHVP"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042281">
        <property type="entry name" value="GpdQ_beta-strand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042283">
        <property type="entry name" value="GpdQ_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="2"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="277"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="507" mass="58174" checksum="D86F459C820E8161" modified="2011-05-03" version="1">MIRIAHISDTHITQDPAFKSYAYDLIVNEVNRSDFDLVIHTGDVTNQGLKEEYEHASYLIRKIEKPLIVLPGNHDARNVGYELFEKYIGPLYGVYERDDLVIIWIDSTIPDLSDGRVGGYKFRWLKEKLEEYSHKKFKIVAAHHHLVPLPDTGRERNVLYNAGDVLDLLLRHEVNLYLCGHKHVPNVYSIEDLVVVNAGCTSCRKTRKGDVNSYNIIKLNGDGRIDVTIRRVTGDEEKKSYKSVKPKLFIPKGKHLLRIVQMSESNVSDRIYFRKRVLENAIRAINEKYKPDLVIHCGDIVDVGIERYYEAAAGYYEKIKAEKMIVPGHNDITYLGYDLFKEYFGEPEIKEFGDFVFIPLLTAQYETPIGVVGRMGQRLLKSLLEEHKEKFTAVVMHHNLIPIPRSRELGFLEDAGNVLKILTEERTELVMTGHGGNAFGVRIERTPIVNAGSVSWELQRDPFGNSFNLIDIYEDMIVAFEIQATWGSRKLLGIWKIKTEVPWKNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJG6</accession>
    <name>F0LJG6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein TERMP_00455</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466730.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00455"/>
    <dbReference type="EnsemblBacteria" id="ADT83432">
        <property type="protein sequence ID" value="ADT83432"/>
        <property type="gene ID" value="TERMP_00455"/>
    </dbReference>
    <dbReference type="GeneID" id="10040773"/>
    <dbReference type="KEGG" id="tba:TERMP_00455"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.455"/>
    <dbReference type="eggNOG" id="arCOG00215">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_0_5_2"/>
    <dbReference type="OMA" id="IGNVIVM"/>
    <dbReference type="OrthoDB" id="61519at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_A">
        <property type="entry name" value="CinA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023055">
        <property type="entry name" value="CinA_Arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="252" mass="28546" checksum="BCADF0D75B5BC691" modified="2011-05-03" version="1">MFAEVLTIGDELLTGHTVDSNSAYIAQRLTEKGYWVRRKTTVGDDVEEIKTVIREILSRKPSVLIISGGLGPTHDDVTMLAVAEALGRKLILREDCLKRIEEFYRELYEKGLIDDPKLNEARKKMAYLPEGAEPLKNTEGAAPGAYIEHEGVKIFVLPGMPREMKAMLENEVLPKLGERKFIQRKLLAEITDESKLAPILNETLKRFPVKIHSSPKGFGKYIGIILFGEDEESIEKAKKFMEEKGIRFEEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJG8</accession>
    <name>F0LJG8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5615 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00457"/>
    <dbReference type="EnsemblBacteria" id="ADT83434">
        <property type="protein sequence ID" value="ADT83434"/>
        <property type="gene ID" value="TERMP_00457"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00457"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.457"/>
    <dbReference type="eggNOG" id="arCOG04290">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07520">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1922895_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041049">
        <property type="entry name" value="DUF5615"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18480">
        <property type="entry name" value="DUF5615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5615" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="131" mass="14847" checksum="AD8291BFAB01AFE8" modified="2011-05-03" version="1">MWIVVDPEICHGKPVFKGTRILVSDVLEMIAAGMSIEEILKEYPQLSEEMIREAIEYAARLIRENIMSLRFLLHAVHVPKGAKDSEVAKIAKSTNSILLTRDSDFANTLMYPRTSSLGSFFLKHILRSQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJL0</accession>
    <name>F0LJL0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0216 protein TERMP_01677</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0216 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467950.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01677"/>
    <dbReference type="EnsemblBacteria" id="ADT84652">
        <property type="protein sequence ID" value="ADT84652"/>
        <property type="gene ID" value="TERMP_01677"/>
    </dbReference>
    <dbReference type="GeneID" id="10041993"/>
    <dbReference type="KEGG" id="tba:TERMP_01677"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1676"/>
    <dbReference type="eggNOG" id="arCOG01921">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146474_0_0_2"/>
    <dbReference type="OMA" id="LHNLKSN"/>
    <dbReference type="OrthoDB" id="112654at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00585">
        <property type="entry name" value="UPF0216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002746">
        <property type="entry name" value="UPF0216"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01886">
        <property type="entry name" value="DUF61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005264">
        <property type="entry name" value="UCP005264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="135" mass="15912" checksum="76E50BD55AF8A262" modified="2011-05-03" version="1">MPQPDEIINKEIARINLHLPRARKSLAKLLNEDVPKVQLRDGSFHYFKKEELEYLQSLLDVEELEKLHLPIVLEITTAWHGYFRVRGKVEVKVIEKVLGTYDILEEKVEVTLPRYLLPKIRRTLPTTTTYAFIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJQ4</accession>
    <name>F0LJQ4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisS</name>
        <name evidence="10" type="ordered locus">TERMP_01721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467994.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01721"/>
    <dbReference type="EnsemblBacteria" id="ADT84696">
        <property type="protein sequence ID" value="ADT84696"/>
        <property type="gene ID" value="TERMP_01721"/>
    </dbReference>
    <dbReference type="GeneID" id="10042037"/>
    <dbReference type="KEGG" id="tba:TERMP_01721"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1720"/>
    <dbReference type="eggNOG" id="arCOG00404">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_3_0_2"/>
    <dbReference type="OMA" id="CDFDFIG"/>
    <dbReference type="OrthoDB" id="47919at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00125">
        <property type="entry name" value="HisZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004517">
        <property type="entry name" value="HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00443">
        <property type="entry name" value="hisZ_biosyn_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT84696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="437" mass="49554" checksum="F65DDD37FE048582" modified="2011-05-03" version="1">MVKERIERVKGTRDLLPEDMAKRRWVFERIREVFEVYGFKEILTPTFEYTKLFQLRSGEEVVKQLYAFKDKGGRDISLRPDLTSSVARLFVNKFQNVPKPVKWYYITNMFRYEEPQSGRLREFWQAGVELIGSANIEADAEVIALMIESYLSTGLKDFTVNIGDRVLLDEFAKMLGVEDDIGLMRLIDKKDKMSREDFIAALKDFGLSDEAVEKVLFLIELKGKPDEILPKAYELFKSDKAKEELKKIEELFELLKAYGVYDYALIDFGIARGFDYYTSIVFEAIAPNDLGIGSIGGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILESKGLLPSFRLSPDVFVVYIGKELEVKAKAIEITQALRKAGIKAEYDLQGRKLRKALEYADKLEIPVVVILGKRDLAEGKATIRDMATGEQKSVAIEKIAKEVKEMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJQ6</accession>
    <name>F0LJQ6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467996.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01723"/>
    <dbReference type="EnsemblBacteria" id="ADT84698">
        <property type="protein sequence ID" value="ADT84698"/>
        <property type="gene ID" value="TERMP_01723"/>
    </dbReference>
    <dbReference type="GeneID" id="26137074"/>
    <dbReference type="KEGG" id="tba:TERMP_01723"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1722"/>
    <dbReference type="eggNOG" id="arCOG02219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157020_0_0_2"/>
    <dbReference type="OMA" id="NARDYMI"/>
    <dbReference type="OrthoDB" id="107306at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="133" mass="15592" checksum="CF4A62DF9724AC6E" modified="2011-05-03" version="1">MKIVLDTNVLHDKEFLKWLKKSPHEPILSAVAYIEYLYHHAKKRGSYEEGKAYVDAFLNVLGIRVYPFDDECAKIVVKNALGRWDFSKNARDYMIGALAVKLNAPLITNNKKDFEWYSKVYTPNEFMKLMKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJQ9</accession>
    <name>F0LJQ9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467999.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84701">
        <property type="protein sequence ID" value="ADT84701"/>
        <property type="gene ID" value="TERMP_01726"/>
    </dbReference>
    <dbReference type="GeneID" id="10042042"/>
    <dbReference type="KEGG" id="tba:TERMP_01726"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1725"/>
    <dbReference type="eggNOG" id="arCOG04197">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064882_1_0_2"/>
    <dbReference type="OMA" id="DPWNKEW"/>
    <dbReference type="OrthoDB" id="37913at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010094">
        <property type="entry name" value="Transposase_put_N"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01765">
        <property type="entry name" value="tspaseT_teng_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="353" mass="40776" checksum="A3ACAF86845339EE" modified="2011-05-03" version="1">MAGKTRKIRRAEVNYITIKTRLKPETKDDYLKLALLCERFKKAVELAIRFQLKGLKKSEGVKEISRLILNNWWYSDSAWDYAKMLLKGTTQNGGNPKHIHLKSKFLISKPKENENGNRNVRMEGVKVKIRSNGEWLNFKLKTVGKFLPVVLNAQKSKYGAQIVLKNGRAYLHLQIPFWIYLEHFRRTTKGRLYAGFDLNSDRVNMVILDENGIIRDVKVVHFPEVNSPGFSKWKAKDSRVKALSQLLDYAYYHGVRVVFFEDLERIKRRNGKAASSRRGNRKALNFAKKELLEHGVIIALKRGFEVFLVNPAGSSKLGKELSRRLGFDVHSSSAFVIGWWGLNYLKTHKIKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJV5</accession>
    <name>F0LJV5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S_layer_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466790.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83492">
        <property type="protein sequence ID" value="ADT83492"/>
        <property type="gene ID" value="TERMP_00515"/>
    </dbReference>
    <dbReference type="GeneID" id="10040833"/>
    <dbReference type="KEGG" id="tba:TERMP_00515"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.515"/>
    <dbReference type="eggNOG" id="arCOG07087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034059_0_0_2"/>
    <dbReference type="OMA" id="YLATYDI"/>
    <dbReference type="OrthoDB" id="5695at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032560">
        <property type="entry name" value="DUF4932"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022651">
        <property type="entry name" value="S_layer_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16286">
        <property type="entry name" value="DUF4932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05124">
        <property type="entry name" value="S_layer_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S_layer_C" evidence="1">
        <location>
            <begin position="454"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="595" mass="70503" checksum="601209C5E6A704B9" modified="2011-05-03" version="1">MRKLLIFLIFVILTSPVYSYQYQTDKVYVEINPNEELLSIVYYLAFGADEFVIPHHDYIQDVEAYFASYKNHTAVQILRQYFSDAETIPQRDYKLFVLDAYILQFSNPPEMKRIYAGWQDSDLDKIIDALRTFAQDTNFMEFFKAHERYYKRDLEVYTSAIHLLPPDEFMKHYMNLTNVMFEFHLPYLLCIHGHSFYAKDNGTEIYGSGGMPPLVRRAPPRTLWSLERAKDTIFGVPLNAVYVNNRKFDELWILDFIYHELGHDITSEKLDEYYSSEVEPLRYLEDTIEEDMPYLATYDIHFWFDTMMIYESFADAWAYFALSHIDKDYAEWNLQMQKAWGEFWQDYMITLYQKYTALSIKENRSFSEYTPLILKELVEKIPPENTKEIYENNVPVTPLRALDDTVREGEVVIVYGTQNPDKKGSEYDRETAEIVKSYLETFYSQWHEYIKIEVKADVNMTNEDLRKDLILIGGPVSNKVVQQFEGYFPLRFVYKNGAWILEKNPEFGSVRTFLITPDNIKEIPFMELSYSSPQTSLLLAIRNPLKKDNYIIWIAGADRYSTRRYRNPTYYLVSYEIYDGEKIEDGFYVQPLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJV7</accession>
    <name>F0LJV7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine-guanine phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00517"/>
    <dbReference type="EnsemblBacteria" id="ADT83494">
        <property type="protein sequence ID" value="ADT83494"/>
        <property type="gene ID" value="TERMP_00517"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00517"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.517"/>
    <dbReference type="eggNOG" id="arCOG00040">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080904_0_0_2"/>
    <dbReference type="OMA" id="VVYPWNF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="28"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="226" mass="25890" checksum="A975C1AA8832938C" modified="2011-05-03" version="1">MPNSLTPLREIMKKFPAYLASWDDIERWAKGGAQKILDEGWKPDVVVGLARGGWVPARLYCDYLGIKDLVSIKVEHWGITATPDGKAKLKYGTEYPFEGKKVLIVDDIADTGESLTLAKSYVESKSPAEVKAATLLVIKTSKFRPDYYGEEIDWAWIVFPWNFVEDMINLTNNLFEEKEKLTTDEIIALFRELHGIEVPKERLEHALGIAEKRKIFKREGEFWLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJZ2</accession>
    <name>F0LJZ2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CobZ-like alpha-ribazole-5'-phosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466827.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00552"/>
    <dbReference type="EnsemblBacteria" id="ADT83529">
        <property type="protein sequence ID" value="ADT83529"/>
        <property type="gene ID" value="TERMP_00552"/>
    </dbReference>
    <dbReference type="GeneID" id="10040870"/>
    <dbReference type="KEGG" id="tba:TERMP_00552"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.553"/>
    <dbReference type="eggNOG" id="arCOG01869">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120791_0_0_2"/>
    <dbReference type="OMA" id="YDAKKPG"/>
    <dbReference type="OrthoDB" id="73343at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06971">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036681">
        <property type="entry name" value="PgpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017577">
        <property type="entry name" value="Ribazole_CobZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007686">
        <property type="entry name" value="YutG/PgpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04608">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101307">
        <property type="entry name" value="SSF101307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03161">
        <property type="entry name" value="ribazole_CobZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PgpA" evidence="1">
        <location>
            <begin position="15"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="152" mass="16983" checksum="BDD633E09BAE9FAA" modified="2011-05-03" version="1">MKAGEILRRLESKGITLEKMLDTALELYIGGDAEKIRKKLKPLMLHYLKDVNVQALLMAALLLEKNFKVKGDPVNLVADELIGIDLAEYIGGKIALFNFFYYDTKKPGILKELPPFLDDAVGGFIAGCMTKLFETMHFDSAETPSEGRETEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK07</accession>
    <name>F0LK07_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Riboflavin kinase</fullName>
            <shortName evidence="17">RFK</shortName>
            <ecNumber evidence="5 17">2.7.1.161</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">CTP-dependent riboflavin kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 17">CTP:riboflavin 5'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Flavokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ribK</name>
        <name evidence="19" type="ordered locus">TERMP_00567</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 17">Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>CTP + riboflavin = CDP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.1.161"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the archaeal riboflavin kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.161" evidence="5 17"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466842.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00567"/>
    <dbReference type="EnsemblBacteria" id="ADT83544">
        <property type="protein sequence ID" value="ADT83544"/>
        <property type="gene ID" value="TERMP_00567"/>
    </dbReference>
    <dbReference type="GeneID" id="10040885"/>
    <dbReference type="KEGG" id="tba:TERMP_00567"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.568"/>
    <dbReference type="eggNOG" id="arCOG01904">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088476_0_0_2"/>
    <dbReference type="OMA" id="AYYVRQY"/>
    <dbReference type="OrthoDB" id="91297at2157"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01285">
        <property type="entry name" value="Riboflavin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039063">
        <property type="entry name" value="RibK_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023470">
        <property type="entry name" value="Riboflavin_kinase_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023602">
        <property type="entry name" value="Riboflavin_kinase_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40706">
        <property type="entry name" value="PTHR40706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01982">
        <property type="entry name" value="CTP-dep_RFKase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 17" id="KW-0288">FMN</keyword>
    <keyword evidence="12 17 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="18">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="95"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="191"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ADT83544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="211" mass="23971" checksum="873BD7956AB6D384" modified="2011-05-03" version="1">MKKLKLILQIAKNGAIGEKVKITLRELSRELEVSPQTVLRWLDELEKEGYITRTVEGKKTCIELTDKALMYLEELYEQLSNVLYQGVIIGEVISGLGEGAYYVRQYAPLIREYLGFEPYPGTLNIKIIFPKTIFDALCNVKPILIPGFVKNGRTFGDVRAYKVKINGIEGAIVIPSRTIHPPRIAEVIAPIYLRRELNLKDGSRIKLKVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK10</accession>
    <name>F0LK10_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">S-adenosylmethionine synthase</fullName>
            <shortName evidence="14">AdoMet synthase</shortName>
            <ecNumber evidence="6 14">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">mat</name>
        <name evidence="15" type="ordered locus">TERMP_00570</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the AdoMet synthase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="6 14"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466845.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00570"/>
    <dbReference type="EnsemblBacteria" id="ADT83547">
        <property type="protein sequence ID" value="ADT83547"/>
        <property type="gene ID" value="TERMP_00570"/>
    </dbReference>
    <dbReference type="GeneID" id="26135888"/>
    <dbReference type="KEGG" id="tba:TERMP_00570"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.571"/>
    <dbReference type="eggNOG" id="arCOG01678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057642_0_0_2"/>
    <dbReference type="OMA" id="IGHPDSI"/>
    <dbReference type="OrthoDB" id="21658at2157"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.280">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00136">
        <property type="entry name" value="S_AdoMet_synth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027790">
        <property type="entry name" value="AdoMet_synthase_2_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042544">
        <property type="entry name" value="AdoMet_synthase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002795">
        <property type="entry name" value="S-AdoMet_synthetase_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36697">
        <property type="entry name" value="PTHR36697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01941">
        <property type="entry name" value="AdoMet_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 14" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="139"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADT83547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="405" mass="45111" checksum="9B53D64D8628DFCA" modified="2011-05-03" version="1">MAEKKRNIVVEELIRTPVEMQKVELVERKGIGHPDSIADGIAEAVSRALSREYIKRYGIILHHNTDQVEVVGGRAYPRFGGGEVIKPIYILLSGRAVEFIDREMFPVHEVAIKAAKEYLRKAVRHLNVEEHVVIDSRIGQGSVDLVSVFNKAKENPIPLANDTSFGVGYAPLSETEKIVLETEKLLNSPEFKKKWPAVGEDIKVMGLRKGDEIDLTIAAAIVDSEVANPKEYMEVKQGIYDAVKELVEEHTSRKVNIYVNTADDPEKDIYYITVTGTSAEAGDDGSVGRGNRVNGLITPNRHMSMEAAAGKNPVSHVGKIYNLLAMLIANDIAKQIEGVQEVYVRILSQIGKPIDEPLVASIQIIPKQGYKIESFERDAYEIADEWLANITKIQRMIIEDKLNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK31</accession>
    <name>F0LK31_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Archaea-specific Superfamily II helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468040.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01768"/>
    <dbReference type="EnsemblBacteria" id="ADT84743">
        <property type="protein sequence ID" value="ADT84743"/>
        <property type="gene ID" value="TERMP_01768"/>
    </dbReference>
    <dbReference type="GeneID" id="10042084"/>
    <dbReference type="KEGG" id="tba:TERMP_01768"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1767"/>
    <dbReference type="eggNOG" id="arCOG00554">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010611_0_0_2"/>
    <dbReference type="OMA" id="SRRRCHE"/>
    <dbReference type="OrthoDB" id="3149at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043852">
        <property type="entry name" value="DUF5814"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19131">
        <property type="entry name" value="DUF5814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="226"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="404"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="834" mass="96216" checksum="D9CFEA98667D7232" modified="2011-05-03" version="1">MLFVIRKGRKKNELEAYYIEKEPEKLSQMQNLKADKIYRLIMRDNRLFKVLEGSQYRNPKEVEKLLRQARVVLVDADEWENYFKVRLQNKRVEKAHLCRFCLLSGKITVLTEGNRIKFHSEYICEGCAEEELKNELRYRFRSLGMFDQAKKLLQRFRDLDKVLMVFDPRFDPTKNPEVTKWDELKPKKIKVKKLNIDELEIPEELKDVLKSEGIRELLPVQSLAIQHGLLKGENLLIVSATASGKTLIGELAGVPKAMKGEKMLFLVPLVALANQKYEDFKRRYSKLGLRVAIRVGMSRIKTKDELVVVDTGIDADIIVGTYEGIDYLLRAGRKIGRVGTIVIDEIHMIDDEERGARLDGLIARLRKLYPKAQFIGLSATIGNPEELSKELGLKLVLYDERPVALERHVILARNESEKWRYIAQLAKAEAMRKSKQGYKGQTIVFTFSRKRCHELAAFLTSRGLKAKPYHSGLPYHQRKLTEMEFQAQMLDVVVTTAALGAGVDFPASQVIFESLAMGNKWLSVREFHQMLGRAGRPLYHEKGKVYLIIEPGKKYSAQMEQSEDEVAFKLLTASIEPVYLEWSDELEQDQVLAHACVFSYLDDIEEVQSRCLGANQSAEEVLKKLEEYEFVKLRGKLVNVTPYGRAVSMSFLLPSEAQFIRENLTKKSPREIAITLLPFENVYLSGTLQRELEGAVRGRLSANIFSPSFASILEELEKVIPELSPNAQERLFTIYQDFFMCEEKECTEYAMHRISDRIMELRREGKHPTQISEYFRKMYGLILYPGDIFTWLDGIIRKLEAVERIAKVFRVKNAEFEARTLRRELEEGRKLRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK43</accession>
    <name>F0LK43_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01780"/>
    <dbReference type="EnsemblBacteria" id="ADT84755">
        <property type="protein sequence ID" value="ADT84755"/>
        <property type="gene ID" value="TERMP_01780"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01780"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1779"/>
    <dbReference type="eggNOG" id="arCOG00054">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057700_0_0_2"/>
    <dbReference type="OMA" id="LDTCMGL"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009452">
        <property type="term" value="P:7-methylguanosine RNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="283" mass="32597" checksum="75AA2DA3D4A51251" modified="2011-05-03" version="1">MKPGFQAYFLTFREARRILLSRGEVKLNLDLRKTNRTFAVKVEDDKIIFPDGSEVEKKIIEKIAKDEGTVYFVKNGHVFKAAIAGEHFYKLVPTIPPTIEINGIRMHRTKDTNPLWDTRAKIKAVEPKEGEFVLDTCMGLGYTAIESAKRGAYVITVEKDPNVIELAKLNPWSYEVFHSQNIQVVQGDVFDVIRKFRDETFNVIVHDPPRFSLAGELYSEEFYAELFRVLKPGGRIFHYVGNPGKKFRRKDLQRGVMERLRKVGFKNVKRVEEALGILGWKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK53</accession>
    <name>F0LK53_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468061.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01790"/>
    <dbReference type="EnsemblBacteria" id="ADT84765">
        <property type="protein sequence ID" value="ADT84765"/>
        <property type="gene ID" value="TERMP_01790"/>
    </dbReference>
    <dbReference type="GeneID" id="10042106"/>
    <dbReference type="KEGG" id="tba:TERMP_01790"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1789"/>
    <dbReference type="eggNOG" id="arCOG02193">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154665_1_0_2"/>
    <dbReference type="OMA" id="VKREHHF"/>
    <dbReference type="OrthoDB" id="109405at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018664">
        <property type="entry name" value="DUF2103_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09876">
        <property type="entry name" value="DUF2103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="97" mass="11111" checksum="43FD1280593047C2" modified="2011-05-03" version="1">MKRKSKVKLEHHLLKGILPALEEIAEIEGVKKVIPGRIYASDSRGFEIKVVRETLTGLKLLAKSDGSVQEIFLVVDKKDRKRVSEEIERISEKWKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK66</accession>
    <name>F0LK66_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468074.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01803"/>
    <dbReference type="EnsemblBacteria" id="ADT84778">
        <property type="protein sequence ID" value="ADT84778"/>
        <property type="gene ID" value="TERMP_01803"/>
    </dbReference>
    <dbReference type="GeneID" id="10042119"/>
    <dbReference type="KEGG" id="tba:TERMP_01803"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1802"/>
    <dbReference type="eggNOG" id="arCOG00899">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048072_1_1_2"/>
    <dbReference type="OMA" id="FINNVTP"/>
    <dbReference type="OrthoDB" id="36454at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="341" mass="38297" checksum="92F6FC0FA25B513A" modified="2011-05-03" version="1">MKKKRIPMIIIGVLLIFALIWWAGIDETMEIIAGAKINYLLLALTMQLFATLAWALRWQVFLKRAGVKIGFWSIMVATFIGVFFNNITPGARAGGEPARMVVVSKTSRSKSTYGQVFATIMADRILDVIPVMVFTFIAFKYALILKIHILLLVLSVSTVALVSILVISILLSFNERLAMRFLKAIILLLKRIFPKKFEGIEEKLEEKLKKSIFEFRKTLKELSTDKSVLMKTLFYSFALWVFMLLRTYFVFRSIDYPLELYKILMVQMAGIALGMVSILPGGIGITEAVNSALYLSLSIDKSLAVTATVIDRFVSFWLPSIVGGALSVYLGVKSGGIKEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK68</accession>
    <name>F0LK68_THEBM</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01805"/>
    <dbReference type="EnsemblBacteria" id="ADT84780">
        <property type="protein sequence ID" value="ADT84780"/>
        <property type="gene ID" value="TERMP_01805"/>
    </dbReference>
    <dbReference type="GeneID" id="10042121"/>
    <dbReference type="KEGG" id="tba:TERMP_01805"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1804"/>
    <dbReference type="eggNOG" id="arCOG05735">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1590951_0_0_2"/>
    <dbReference type="OMA" id="YPHPAFE"/>
    <dbReference type="OrthoDB" id="79897at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024505">
        <property type="entry name" value="DUF3201"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11447">
        <property type="entry name" value="DUF3201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="170" mass="20432" checksum="FED24101C18BCFC7" modified="2011-05-03" version="1">MNLLDVHNLLNFIWGETFRLNEELREKLKPLGFKVEPVEEVFNAYIYLDGEWREMLYPHPAFEIKPGGEVGATLQGFYFVFGILKEKISEEFVKEFIEKFRKSYIYGSENFLEDFYNYQSPKEPNEVFKEIKESEEKIINFEVGELTVEELERYLFDFIELIKKYSLFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK79</accession>
    <name>F0LK79_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468087.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01816"/>
    <dbReference type="EnsemblBacteria" id="ADT84791">
        <property type="protein sequence ID" value="ADT84791"/>
        <property type="gene ID" value="TERMP_01816"/>
    </dbReference>
    <dbReference type="GeneID" id="10042132"/>
    <dbReference type="KEGG" id="tba:TERMP_01816"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1815"/>
    <dbReference type="eggNOG" id="arCOG10029">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_890311_0_0_2"/>
    <dbReference type="OMA" id="LENTSMI"/>
    <dbReference type="OrthoDB" id="94768at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="312" mass="34773" checksum="AAE631795382D4F8" modified="2011-05-03" version="1">MKKLGVLLVGILLVGLVAGCIGGKSTSTTSTTAQTSTTQPQTMTSSTSITNIPTTTTSSPSKTITQTKTQIQPKIYSREELLDNLRKIKQFTYLENVSVTLDVKIKQGNLTFNAGEVSITSKKVGYVDLINKESDINTTTTTFPGGATTFTREIIKDGEVYLYSNGVWKKLTNESFILPPEAVLNLTWGYNVVSFVEKYLQKEPFNKTIENGTQIFYYNVTTEDLTQLARFFIGFKDTNVTFNVSKGILEVKFRNGNLIGGRVAYNMEIKILTKDPQGRTVEVIETGREYEEFVVKDINVKKNVKKPVSYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK80</accession>
    <name>F0LK80_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_01817</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468088.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01817"/>
    <dbReference type="EnsemblBacteria" id="ADT84792">
        <property type="protein sequence ID" value="ADT84792"/>
        <property type="gene ID" value="TERMP_01817"/>
    </dbReference>
    <dbReference type="GeneID" id="10042133"/>
    <dbReference type="KEGG" id="tba:TERMP_01817"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1816"/>
    <dbReference type="eggNOG" id="arCOG01334">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_770785_0_0_2"/>
    <dbReference type="OMA" id="LPFKIYK"/>
    <dbReference type="OrthoDB" id="114430at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="193"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="383" mass="43481" checksum="DFD9C2977149A161" modified="2011-05-03" version="1">MDWVIFFLVISIITITVPPLIMRLQREKILKGETSNDEKMYKGTKLMLLCIILAIGLYFPPVIGLGILDKVMEPLAEHISSPFLGALIFMGVFITPLLISIMLTILVASKIEVEVKGLNIKTWETVKGILKAFAFLLLPGIVWLGIYLNLPEKIRNSTLASFGVFVIYILSFFALSPYLTRFFGKPRQVPEPLRTELLKFCESLGFKVRDIRVTGKKEYKIANAGVTGILPWARYIFITEYMLETFEPEEIKAVIAHEIGHIKGRHLWINALIAIGWFGFWMGIVFALIKLGVDILSPVVFFGVFFSAYIIYFVVIQGKISLRNEFKADEFAAKVIGKETVIKTLEKLAEVNLTPKKTGKWFGFLSFHPSIEERIRHLEEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKB5</accession>
    <name>F0LKB5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter, ATP-binding protein component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466871.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00596"/>
    <dbReference type="EnsemblBacteria" id="ADT83573">
        <property type="protein sequence ID" value="ADT83573"/>
        <property type="gene ID" value="TERMP_00596"/>
    </dbReference>
    <dbReference type="GeneID" id="26135864"/>
    <dbReference type="KEGG" id="tba:TERMP_00596"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.597"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="ASHNMAE"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="304" mass="34672" checksum="08CE7849BBE6ED92" modified="2011-05-03" version="1">MYAIEIENLTKSYGNLKAVDDLTLNVEKGIVFGFLGPNGAGKTTTILSMLGLIIPDSGSIRILGHDVFREPIQVKEKIGFLPENATIYEELTAWKNLDFFANFYRFSRQEKEKRIEELLKLVGLWDVKYRKVKTFSKGMKQRLLLAQALINDPEVLILDEPTSGLDPEGAYLVKSIVKEEREKGKTVFFSSHVLSEVEELSDKVGIIVKGRLRALGTLEEIKKEFMELEGYEIKVETKQPLPEIDLPEIISIKRIGDSRAIIFAKEDIREELSEYLSRKGITILSLEIEEPSLEDVFLKTIYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKH5</accession>
    <name>F0LKH5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Triosephosphate isomerase</fullName>
            <shortName evidence="2">TIM</shortName>
            <shortName evidence="2">TPI</shortName>
            <ecNumber evidence="2 3">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tpiA</name>
        <name evidence="4" type="ordered locus">TERMP_01834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="2 3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468105.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01834"/>
    <dbReference type="EnsemblBacteria" id="ADT84809">
        <property type="protein sequence ID" value="ADT84809"/>
        <property type="gene ID" value="TERMP_01834"/>
    </dbReference>
    <dbReference type="GeneID" id="10042150"/>
    <dbReference type="KEGG" id="tba:TERMP_01834"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1833"/>
    <dbReference type="eggNOG" id="arCOG01087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104921_0_0_2"/>
    <dbReference type="OMA" id="IPVYAQH"/>
    <dbReference type="OrthoDB" id="60670at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_A">
        <property type="entry name" value="TIM_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022891">
        <property type="entry name" value="Triosephosphate_isomerase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="225" mass="23785" checksum="429AE82D962EFD23" modified="2011-05-03" version="1">MKLKEPIIAINFKTYAQATGEGALRIAKAAEKVYKETGITIVVAPQLADLYRIAQEVEIPVFAQHIDPIKPGSHTGHVLPEAVKEAGAVGTLLNHSENRMILADLEAAIRRSEEVGLMTMVCSNNPKVSAAVAALDPDYVAVEPPELIGTGIPVSKAKPEVITDTVELVKKVNPNVKVLCGAGISTGEDVKKALELGTVGVLLASGVTKAKDPEKAIWDLVSLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKH6</accession>
    <name>F0LKH6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468106.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01835"/>
    <dbReference type="EnsemblBacteria" id="ADT84810">
        <property type="protein sequence ID" value="ADT84810"/>
        <property type="gene ID" value="TERMP_01835"/>
    </dbReference>
    <dbReference type="GeneID" id="26137360"/>
    <dbReference type="KEGG" id="tba:TERMP_01835"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1834"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062979_2_0_2"/>
    <dbReference type="OMA" id="RYGVIFN"/>
    <dbReference type="OrthoDB" id="86536at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="3">
        <location>
            <begin position="112"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="341" mass="39032" checksum="57762373D3A22ACD" modified="2011-05-03" version="1">MSEKELKGLLRELGFSEYEVSAYLTLIKEGPLTAGELATLSKVPQPRIYDVIRTLMGKGFVITIGGRPKKVVAVNPEKVFSEIERKYVRKVSLVKEMLKEIYNPRDGEIGNIIVVKSKITFEKYVKDAIKNAKRHISLALPISFLKRIQDDLIKKKKMGVEIDLFVYGVGEIPPVAHKIKIREVPDPFILIQDKETGIYAPSEALNSKTSGLHGYAMIIKDENLLFMFDRYFYHALWPTGRTVYEEERKLILPREYIHIRKLVRDIRLFNLVNSKVRIIGKFVKSKEPVEIEGRIVDYYEDKAKVISNITVETKDGKKYVVGGWNSSLEDIEADLIVIEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKT0</accession>
    <name>F0LKT0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466957.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00682"/>
    <dbReference type="EnsemblBacteria" id="ADT83659">
        <property type="protein sequence ID" value="ADT83659"/>
        <property type="gene ID" value="TERMP_00682"/>
    </dbReference>
    <dbReference type="GeneID" id="10041000"/>
    <dbReference type="KEGG" id="tba:TERMP_00682"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.683"/>
    <dbReference type="eggNOG" id="arCOG04500">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_400978_0_0_2"/>
    <dbReference type="OrthoDB" id="18112at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="688" mass="79910" checksum="887A0D8CE1913DDF" modified="2011-05-03" version="1">MQIDLRKAGLILIVIYVLALMLAFRPPQVKKPVVPVNTYSLESDYEYIAEQLGFLSDGKISEGELEIIEKVYPVYKYHTSLFEDVEITDTEKFAELCWQVTQTLNSVPLALRDDMLRFLFSDSPYTLEEFSKKVQIFNAQVREFVNVYSTLPPHIRTGIENSHYIYQVRSLTEYIQLIKELSMSLSGLPPKIVNAIDNMQGLFGGFEPYEISEFISGINAVRHEMLSNTTYREWFIRNAHKFEISKVYNTWTEFQKEHINDRTPPRMRGRVESLPSGAVEVSLTIEDNANPPRQVRIFVNGKEKSSTKINTESLSYTHVIQFPLKWGNYTITIEAYDAKGNKNSISLVLAHYPLVFPIYFNGKGRYWFQNAQLYTESQIEYMWRKAAEFKPLQVYEAVYPDLGFTRYHKIKLDGAMKFFYDDAKRKLLNYYKKPVPFYSITPLHIAYFVNIYVHSYDVPIVGTLESGICGYDGETEVVFLNNLFMDFNIDAWAIQIPASLSGGKLDHSEVIVIWRVPLLIGSSYRAFYVLGLDPYPKIPEHIYPFEPDWPKKYSRETIELMALGLIPYRPDKFALREFYERFGIKVTPAYPLKDISKEFITGYEFFASYISFQISDAYMKKLLTMITHGDLSILNELNKLEAARSLWYRLDGHNLYSGPGYSPDYVYIDSDGNFYYVHRNRSKAFSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKU7</accession>
    <name>F0LKU7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_00699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466974.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00699"/>
    <dbReference type="EnsemblBacteria" id="ADT83676">
        <property type="protein sequence ID" value="ADT83676"/>
        <property type="gene ID" value="TERMP_00699"/>
    </dbReference>
    <dbReference type="GeneID" id="10041017"/>
    <dbReference type="KEGG" id="tba:TERMP_00699"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.700"/>
    <dbReference type="eggNOG" id="arCOG00666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_1_2"/>
    <dbReference type="OMA" id="TAIVEHK"/>
    <dbReference type="OrthoDB" id="61185at2157"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023915">
        <property type="entry name" value="Bifunctiontional_GlmU_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03992">
        <property type="entry name" value="Arch_glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="417" mass="46446" checksum="DC4639BB62453D14" modified="2011-05-03" version="1">MKGVVLAAGKGERLKPLTDDRPKVLLKVANRAIIEYVLENLYPFVDEFIIIVRYQKEKLIEFLGDEYNGKPITYVEQTEGEGTARAIYSAKEYIEGESFLAVNGDIYFEREAVKALLHAFRKANAALLVKEFEDLSHFGKVEVEGEYVKEIKEKPGNVRGYANLGIYLFKPDVFEFIEKTPLSKRGEYEITDTINLMIKSGKKVAYAVYDGYWNDIGRPWDLLNLNEYILKNHLKHEIRGTVEEGATIIPPVEIGEGTVVKSGAYIVGPVKIGKNCKIGPNCFIRPYTSIGNHCHIGNAVEIKNSIIMDHSNAPHLNYVGDSIIGENTNLGAGTITANLRHDNKTIKVEVKGKLEDSGRRKLGAIIGHNVKVGINVSIYPGRKIGSNSFVGPGVIVDKNIPPNSLVIVKQQKEIHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL04</accession>
    <name>F0LL04_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84911">
        <property type="protein sequence ID" value="ADT84911"/>
        <property type="gene ID" value="TERMP_01936"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01936"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1935"/>
    <dbReference type="eggNOG" id="arCOG02209">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022017_6_5_2"/>
    <dbReference type="OMA" id="IYYRTDM"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="262"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="347" mass="39652" checksum="431A24C3D71FB669" modified="2011-05-03" version="1">MREIARNKERKNELFPYALGFKITLAVINFGIIIFLVLQLNKSNIIKNLIIIVALENILLQVAYFFTRIMFAHEVTKYEGIAKVIERIWAFFVGGAVLYVKRELAPFILAILAGYLLRDSLRIYWGSKFFEKIRVEFKPDTWINLLKHSYPFWLISLFTMIYYRTDIVMLGLFRPDYDVGIYRAAYTLIQVALFIPNIVVATTMPSMARLWRENKRILNILFKKSFQILLAIGLLGVMGYYIFANFAITIVFGAGFTESVGVLRVLAVAVPFLFLNSLLGSFLNATGKELSFTKITAFTALLNVVLNYFLIQSYSYYGAAIATVVSQALATILSFKIILNNLSQESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL96</accession>
    <name>F0LL96_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467045.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00770"/>
    <dbReference type="EnsemblBacteria" id="ADT83747">
        <property type="protein sequence ID" value="ADT83747"/>
        <property type="gene ID" value="TERMP_00770"/>
    </dbReference>
    <dbReference type="GeneID" id="10041088"/>
    <dbReference type="KEGG" id="tba:TERMP_00770"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.772"/>
    <dbReference type="eggNOG" id="arCOG01330">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075669_1_0_2"/>
    <dbReference type="OMA" id="PYVEKWG"/>
    <dbReference type="OrthoDB" id="91204at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009577">
        <property type="entry name" value="Sm_multidrug_ex"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06695">
        <property type="entry name" value="Sm_multidrug_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="155" mass="17406" checksum="F7AC9F891BD88B6A" modified="2011-05-03" version="1">MNEFVYIFLLSLLPTFEGRYAIVYGIARGYPLWETLLTASLGVLLLSLTLPLFLPLIDVVMVNLEKTFLGKVAEVYLKYVQRVRKKAHPYVEKWGFYGLIIFVAVPLPGTGIWTGSLAAYIFGMENRKTIPALILGGLLSMMITLIPSLGFRFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLA1</accession>
    <name>F0LLA1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467050.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00775"/>
    <dbReference type="EnsemblBacteria" id="ADT83752">
        <property type="protein sequence ID" value="ADT83752"/>
        <property type="gene ID" value="TERMP_00775"/>
    </dbReference>
    <dbReference type="GeneID" id="26136231"/>
    <dbReference type="KEGG" id="tba:TERMP_00775"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.777"/>
    <dbReference type="eggNOG" id="arCOG07083">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195006_0_0_2"/>
    <dbReference type="OMA" id="FHGMPRY"/>
    <dbReference type="OrthoDB" id="126011at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026486">
        <property type="entry name" value="CHP_AF_0576"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04140">
        <property type="entry name" value="chp_AF_0576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="64" mass="7335" checksum="E482F2A417455172" modified="2011-05-03" version="1">MRIITPIPPEELKMILKKSNAAVRLEIKEAKPFHGMPRYEVIISGDKEEVEKFMEKLRLARAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLA9</accession>
    <name>F0LLA9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00783"/>
    <dbReference type="EnsemblBacteria" id="ADT83760">
        <property type="protein sequence ID" value="ADT83760"/>
        <property type="gene ID" value="TERMP_00783"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00783"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.785"/>
    <dbReference type="eggNOG" id="arCOG00388">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054697_2_0_2"/>
    <dbReference type="OMA" id="YGKAYGQ"/>
    <dbReference type="OrthoDB" id="68178at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="378" mass="42128" checksum="BBBF4145D2253B26" modified="2011-05-03" version="1">MIILGLPLTFTPVNASETTVVILVSDNEADCALADYIANITVNVNVVIVKTPWGIYNPNVTAEIISYAPDEVIIIGGPVAVPEEYVEDLQNLGINVERWWGQNRYETDLAVIKNATVRFQLQLQNRVVLVAGTDLAGIEKALQLAIRERAMIVLVNQTTNITKIMERLHVRAGNFTIIGTPAMNQTMLHIMKQLRKQECNCTELHLNITAERALEAIQIAEEKVNTAKELAENATNPALKTLLRIAEKQLEDAKDAYSSGKYGLAYGLAIAAKSKAEVVIRFAGEDIRKMIMSDIKMKLQREIIRVEAQLMVMERLGVNVTAALQLMEAIKAAVRNGDYDTAQELMIKLREELRTCYLAGRGIIKGKVHMPVRRREQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLD1</accession>
    <name>F0LLD1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0020 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467080.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00805"/>
    <dbReference type="EnsemblBacteria" id="ADT83782">
        <property type="protein sequence ID" value="ADT83782"/>
        <property type="gene ID" value="TERMP_00805"/>
    </dbReference>
    <dbReference type="GeneID" id="10041123"/>
    <dbReference type="KEGG" id="tba:TERMP_00805"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.807"/>
    <dbReference type="eggNOG" id="arCOG00047">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_782116_0_0_2"/>
    <dbReference type="OMA" id="VFVFPAY"/>
    <dbReference type="OrthoDB" id="47556at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0020" evidence="1">
        <location>
            <begin position="173"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="364" mass="42609" checksum="4D65FB9E0A6185FE" modified="2011-05-03" version="1">MYALILGKNPKLSEAEFYSFVRRFGLKINVIEASHNWIIFESSKKVEHLFHRLGGALKLVRITGNEENAVKELTYSKLFTVSIYGKEDWKLWRKLGSQIKKIFKGEGSAKFFKPAKVYAMPSELILKGFPETKDFVFIYGEKLWVGETIKITDPFELKKLDVERPVQRAIFSIPPRLARIMVNLTEIRQGNFLDPFCGIGTIVQEFLLQGLNAYGSDSDPKAIKGAKENLKWLKKEFKVKKTAHLEVCDARKLKRCFRTKFDAIVTEPWLGKPLKYNPTRGEAIQMANQLDRFYYQVFDSFRDVLKRNGRVVFVFPAYKLKDGRIYRKERRWLEKLGFEVLAKYTDFEERHRVVRDIHVLRFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLD4</accession>
    <name>F0LLD4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467083.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00808"/>
    <dbReference type="EnsemblBacteria" id="ADT83785">
        <property type="protein sequence ID" value="ADT83785"/>
        <property type="gene ID" value="TERMP_00808"/>
    </dbReference>
    <dbReference type="GeneID" id="26136260"/>
    <dbReference type="KEGG" id="tba:TERMP_00808"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.810"/>
    <dbReference type="eggNOG" id="arCOG01913">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1922903_0_0_2"/>
    <dbReference type="OMA" id="MNIRLVW"/>
    <dbReference type="OrthoDB" id="100631at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="44"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="131" mass="14396" checksum="A7079809B898DB83" modified="2011-05-03" version="1">MKLREMVKDVLKFVFLMIDEIVVGIFLFVVLPSAGVRVPLSLSVTVIALLVIKDIAIVPSFGQILRKKAEVGIEALMGKEAVVVEDLTPEGIVKIGNEYWRAKCINGHAKAGERVKVVRAKGLKLLVECQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLK4</accession>
    <name>F0LLK4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DHH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468329.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02059"/>
    <dbReference type="EnsemblBacteria" id="ADT85033">
        <property type="protein sequence ID" value="ADT85033"/>
        <property type="gene ID" value="TERMP_02059"/>
    </dbReference>
    <dbReference type="GeneID" id="10042374"/>
    <dbReference type="KEGG" id="tba:TERMP_02059"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2056"/>
    <dbReference type="eggNOG" id="arCOG00426">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_907931_0_0_2"/>
    <dbReference type="OMA" id="HWDTDGI"/>
    <dbReference type="OrthoDB" id="39370at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="308" mass="34580" checksum="DBA2065A6BCC605F" modified="2011-05-03" version="1">MLIIHHWDTDGITSAALVAKALDLEEFENLSPPIGEFRLDERIRKAVEKADTVYVLDLNLPNEVEDIDKETVFIDHHIQPKIGNPKVKQINPALNGEYAPSASFVVSQYFGIWNEWSALGALGDMGKKALELPKVRELLRGLTENEALRLVQLLDSNYVVMDREGVEEAVEVLLTHSLKELLEYEPWVKKAEAIEKTINDAIGNLKLRDGFAFITFESPFNVISKVARKAVWELGYNGAVVVNRDFHGKAQIYFRISPKLAEKIDMGGIIFALKERGFNAGGKREVLGCICEKSKADEVLDIINAHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLN0</accession>
    <name>F0LLN0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467105.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00830"/>
    <dbReference type="EnsemblBacteria" id="ADT83807">
        <property type="protein sequence ID" value="ADT83807"/>
        <property type="gene ID" value="TERMP_00830"/>
    </dbReference>
    <dbReference type="GeneID" id="10041148"/>
    <dbReference type="KEGG" id="tba:TERMP_00830"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.832"/>
    <dbReference type="eggNOG" id="arCOG03789">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102063_1_0_2"/>
    <dbReference type="OMA" id="QYTTREN"/>
    <dbReference type="OrthoDB" id="126570at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005489">
        <property type="entry name" value="DUF257"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03192">
        <property type="entry name" value="DUF257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="213" mass="24455" checksum="FCF6B6064B7D26A4" modified="2011-05-03" version="1">MEVFELLESFKRGETVLFLYPPISPSYILLRKVVEYCKKRGLDLYVADIFDMLYTYKTQLEYIDIELDLDDDRISVIKEGGKIHVGNVISRISVDEDAAIHLRKYEEAFESSLQDKEFVFDVTLGFDKLLAFYSESPKDLKMILMAVKDFVGNKKRTAIYFVNQEVVANIGNALEFLIDSATSVIKLEKDADGWYIRVLKSPKIEIVGAKVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLP1</accession>
    <name>F0LLP1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_00841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00841"/>
    <dbReference type="EnsemblBacteria" id="ADT83818">
        <property type="protein sequence ID" value="ADT83818"/>
        <property type="gene ID" value="TERMP_00841"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00841"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.844"/>
    <dbReference type="eggNOG" id="arCOG00066">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_2"/>
    <dbReference type="OMA" id="CLQSANH"/>
    <dbReference type="OrthoDB" id="25049at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="3"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="382" mass="42380" checksum="E3D539ED27F98A6B" modified="2011-05-03" version="1">MVIYLDNANTTKPDPEVIRVMLEYFERKYGTPGGEFGHIFDEESREAVEEAREKIAREINASPEEIIFVSDETEADNLAIKGVAWAKGKGKVLASKIERKAILNTVKRLGEWGFQAYEVSVDKEGFINLDNLQGNLKDAILFATHLGNFEIGTIQDIKAISEIVHDKGALLYLDANHAFGKVKIDVKKLDVDLMSITAHLIHGPKGIAALYIRDGVKLKPLLDGDVRERGIRPGMINVPAIAGFGKAVELINYDDAKRMAKLRDKLIDLLLGIPDTKLNGPRGEKRLPNNVNVSFAYVEGESILLHCDLRGLVFSTGSACYSQELLPSHVIRAIGGSFEDAHGSVRLSLSKWTTEEEIVKAYEIIRDVVEKLREISIYGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLQ8</accession>
    <name>F0LLQ8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase chain M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00858"/>
    <dbReference type="EnsemblBacteria" id="ADT83835">
        <property type="protein sequence ID" value="ADT83835"/>
        <property type="gene ID" value="TERMP_00858"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00858"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.861"/>
    <dbReference type="eggNOG" id="arCOG01537">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_5_2"/>
    <dbReference type="OMA" id="YAVWFGQ"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="603"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="2">
        <location>
            <begin position="119"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="620" mass="68317" checksum="FE2FE1253F5D1C83" modified="2011-05-03" version="1">MINELMIIIFAPLLAGVLAWLLDIKGVREGLGVIGAALPLAYLIQAYQTLGTQSSIQYSILLAGFKFEFLLYQINWIFAMIAGVVGFAAVLGMVSTARDSYEWLFALMSLTGVYGVFLADDLASFFIFWEIMTFGSFMMVLKYNRKASLKYFLLSVFGAYAMLIAIGIIYAKVGALDFATIQQAFYQDAMRGTFGADTLFSRNDMLLVFGLFLVAFGVKAGMFPLHVWAPDAYSETNQSYTAMFSGVLSKAGVYGMLVIYILLGTRLVYQFGRIGAAPKFGYIIALLGGLTIIVGGLLAALQEDIRKLFAYSSISQIGYILVGIGVGTALSIEAAIYHAISHALFKGLFFLIVATIVLRTGKTEFKDMGGLAEKMPITFAMAFVAILSLAGIPPLVGFASKWLLFEAVIHENMPILGGMIFFGSAIGFVYLIRFTYAVWFGQRPTELDDTKDAPLPLAIAMGILALLNVVFGIAPGLVAKELNKIFGKEVIGGTIYELNLGFGRYNGLFITIWLVVGIVIAAIIYFLGAKVRKVPVTDTYQAGNPVTMEYNLTIRRNFFLPLKETLAFWLRMSFDRLYQDIGNWVEDLAETLRHYVYNGNVQAYAWYLAIILLILALWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLU0</accession>
    <name>F0LLU0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_02065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468335.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02065"/>
    <dbReference type="EnsemblBacteria" id="ADT85039">
        <property type="protein sequence ID" value="ADT85039"/>
        <property type="gene ID" value="TERMP_02065"/>
    </dbReference>
    <dbReference type="GeneID" id="10042380"/>
    <dbReference type="KEGG" id="tba:TERMP_02065"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2062"/>
    <dbReference type="eggNOG" id="arCOG02050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_1_0_2"/>
    <dbReference type="OMA" id="MTPILLW"/>
    <dbReference type="OrthoDB" id="77132at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT85039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="246" mass="26863" checksum="864ED8A47F4E655D" modified="2011-05-03" version="1">MFSFIFLGFLVGFLVGLTGIGGGALMTPSLIFLGIEPLMAVGTDLLYATVTRIFGVFFHHRKGSIRFDLALRLFAGSLPAILLGSVLLRVIDKSTLNNYLTLLLGVILVVSSFFSLVKGEFHVPIRPRREYLYLLGFIVGLTVQFTSVGAGVIVSFALMNLAKLSPREVVGVTIFYGLPLSFLSALNYAFLGSTNYHLALLLIAGTLPGVYLGTHVNRKVDRDKLKRVINVIILVIGLLTLFQRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLU9</accession>
    <name>F0LLU9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02074"/>
    <dbReference type="EnsemblBacteria" id="ADT85048">
        <property type="protein sequence ID" value="ADT85048"/>
        <property type="gene ID" value="TERMP_02074"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02074"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2071"/>
    <dbReference type="eggNOG" id="arCOG03166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041137_3_0_2"/>
    <dbReference type="OMA" id="YGRIKRE"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF234" evidence="1">
        <location>
            <begin position="239"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="353" mass="42217" checksum="A6944980591C60FD" modified="2011-05-03" version="1">MREYEEILRKKGVITKYERISSWDEFFEVLFERFNGAVVFDEFQDFQRVEPSIFSTLQKFIDIYENRKNLMLIFTGSTVGMIEKLFRDSKEPLYGRIKRELHVKELGIKASYEMSRELGIDDIDDFMKLYAVFGGFPRYYVAIEDERLEGKSAEEIIRALFFSPSAPLEEEVPRILSLEFGRRSGVYYDMIAGYMNREETSLTRQIKELVDYFKLLSYDKAILGKERVLYIRHPLLNFWFRFIHPRLSEYEAMREDLGKEVISMLPDYTGKRFDFICRELLWILNAREELPFKFTEIGRHWGYYRENGQRKVYEIDVVALSQDKKKALFGECKWRNKPINGEKLLEELKRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM11</accession>
    <name>F0LM11_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_02136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468406.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02136"/>
    <dbReference type="EnsemblBacteria" id="ADT85110">
        <property type="protein sequence ID" value="ADT85110"/>
        <property type="gene ID" value="TERMP_02136"/>
    </dbReference>
    <dbReference type="GeneID" id="10042451"/>
    <dbReference type="KEGG" id="tba:TERMP_02136"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2133"/>
    <dbReference type="eggNOG" id="arCOG01736">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081251_3_4_2"/>
    <dbReference type="OMA" id="HITLRFL"/>
    <dbReference type="OrthoDB" id="102399at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="101"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="41"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT85110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="185" mass="21074" checksum="79079F1CC37DE43F" modified="2011-05-03" version="1">MRAFIAIDISDSVREKLVQAQDKIARTKAAKIKFVEPENLHITLKFLGEITGEQAEEIKEILQKIAAKYKKHDVRVKGIGVFPNPNYIRVIWAGVEGDEIIKSIASDIERELRKLGFKKDKDFVAHVTIGRVKFVKDKLELAVVLKELANEDFGIFRVDAIELKKSTLTPKGPIYETLARFELRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM33</accession>
    <name>F0LM33_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467178.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00904"/>
    <dbReference type="EnsemblBacteria" id="ADT83880">
        <property type="protein sequence ID" value="ADT83880"/>
        <property type="gene ID" value="TERMP_00904"/>
    </dbReference>
    <dbReference type="GeneID" id="10041221"/>
    <dbReference type="KEGG" id="tba:TERMP_00904"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.905"/>
    <dbReference type="eggNOG" id="arCOG01680">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_7_3_2"/>
    <dbReference type="OMA" id="CVCLIAK"/>
    <dbReference type="OrthoDB" id="111287at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="125" mass="15130" checksum="2DC18AE7F576CA26" modified="2011-05-03" version="1">MKIRDLIEKLNEKQKRTVKRCLQSCEIIDLDEEVGIETNEKLLRFLKLISNPIRYKILKMVKNRWMCVCLISQALEEDQTLISHHLRSLKDMNLVYERREGKLKFYRTNLEEVRKYIKLLEAEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM34</accession>
    <name>F0LM34_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467179.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00905"/>
    <dbReference type="EnsemblBacteria" id="ADT83881">
        <property type="protein sequence ID" value="ADT83881"/>
        <property type="gene ID" value="TERMP_00905"/>
    </dbReference>
    <dbReference type="GeneID" id="26136350"/>
    <dbReference type="KEGG" id="tba:TERMP_00905"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.906"/>
    <dbReference type="eggNOG" id="arCOG01911">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067083_0_0_2"/>
    <dbReference type="OMA" id="DKIIMDP"/>
    <dbReference type="OrthoDB" id="78392at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002825">
        <property type="entry name" value="Pept_S49_ser-pept_pro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01972">
        <property type="entry name" value="SDH_sah"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="279" mass="31868" checksum="AABC699C03A7B7F1" modified="2011-05-03" version="1">MDPLSGFLGSLIWWLFFLYLLLWPQMQYRQLQLMRARLLQKLSRKRNSTVITMIHRQESIGLFGIPFYKFISIEDSEEILRAIRMAPKDKPIDLIIHTPGGLVLAATQIAKALKDHPAETRVIIPHYAMSGGTLIALAADKIIMDPHAVLGPVDPQLGQYPAPSIVRAVEKKGPEKVDDQTLILADVAEKAINQVRNFVYELLKDKYGEEKAKELAQILTEGRWTHDYPITVEEAQKLGLHVSTDVPEEVYELMQLYPQPMKQRGTVEFMPYPVRQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM40</accession>
    <name>F0LM40_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467185.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00911"/>
    <dbReference type="EnsemblBacteria" id="ADT83887">
        <property type="protein sequence ID" value="ADT83887"/>
        <property type="gene ID" value="TERMP_00911"/>
    </dbReference>
    <dbReference type="GeneID" id="26136356"/>
    <dbReference type="KEGG" id="tba:TERMP_00911"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.912"/>
    <dbReference type="eggNOG" id="arCOG07113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155021_0_0_2"/>
    <dbReference type="OMA" id="MIIAKPC"/>
    <dbReference type="OrthoDB" id="109824at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="92" mass="10261" checksum="197287D2F7D5991C" modified="2011-05-03" version="1">MIIAKPCVTMKGVVVQLYSWDKEIKLDLDKVSECLKKKGIEIKKLIPNMLLIAVMNGFETSIYPGGKVIIKELTDTKKGEEIAKTVYDCVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM72</accession>
    <name>F0LM72_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Indolepyruvate oxidoreductase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00943"/>
    <dbReference type="EnsemblBacteria" id="ADT83919">
        <property type="protein sequence ID" value="ADT83919"/>
        <property type="gene ID" value="TERMP_00943"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00943"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.946"/>
    <dbReference type="eggNOG" id="arCOG01602">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_1_1_2"/>
    <dbReference type="OMA" id="IGMSQRG"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="12"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="194" mass="21670" checksum="BB220DD71FC5898A" modified="2011-05-03" version="1">MVEFNLIIAGVGGQGGLTLSRIIGNAAMHEGYKVRIGETLGMSQRYGSVLSYLRFGEEVYSPLIEEGEADLMFALEPAEALRNARFLSRKSHAIVNAYPIHTATTLVGKERYPNLDEIKEALLKICPTDMLNFQEVADKINPRTLGVVMLGYAYGRGLIPLKKDSLREGIKETLKEKLWEINFRALEEGIKLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM89</accession>
    <name>F0LM89_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467234.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00960"/>
    <dbReference type="EnsemblBacteria" id="ADT83936">
        <property type="protein sequence ID" value="ADT83936"/>
        <property type="gene ID" value="TERMP_00960"/>
    </dbReference>
    <dbReference type="GeneID" id="10041277"/>
    <dbReference type="KEGG" id="tba:TERMP_00960"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.963"/>
    <dbReference type="eggNOG" id="arCOG01069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_3_2"/>
    <dbReference type="OMA" id="ACGIPYW"/>
    <dbReference type="OrthoDB" id="40511at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="1">
        <location>
            <begin position="324"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="439" mass="48140" checksum="63AF778E47B3BA11" modified="2011-05-03" version="1">MRIVVIGSGTAGSNFALFARKLDRKADIIVIGKEKTMQYSPCALPFVLSGKIPKLEDIVVFPNSFYEKQKIQLMLETEAKEIDRERKVVITDKGEVPYDKLVLATGSRAFVPPIKGVENEGVFTLKSMDDVRKIKAYIEERKPKKAVVIGAGLIGLEGAVAFRELGMEVLVVELLEHLLPTMLDKDMARIVQQHLEEKGISFKFGVGVSEIIGSPVKAVKIGDEEIEADLVLVATGVRANIDLAKKAGLKVNKGIVVNEYLQTSDPDIYAIGDCAEVFDAVTGERTLSQLGTTAVRMAKVAAENVFGKNVRFKPVFNTAITELFDLEIGTFGMTEERAKREGINVVVGKFKGSTKPEYYPGGKPIHVKLIFRKEDRKLIGAQIVGGERVWGRIMTLSALAQKGATVEDVVYLETAYAPPISPTIDPITVAAEMALRRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMD4</accession>
    <name>F0LMD4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NMD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468453.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02183"/>
    <dbReference type="EnsemblBacteria" id="ADT85157">
        <property type="protein sequence ID" value="ADT85157"/>
        <property type="gene ID" value="TERMP_02183"/>
    </dbReference>
    <dbReference type="GeneID" id="10042498"/>
    <dbReference type="KEGG" id="tba:TERMP_02183"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2178"/>
    <dbReference type="eggNOG" id="arCOG04149">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04277">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065087_0_0_2"/>
    <dbReference type="OMA" id="CHMCGSY"/>
    <dbReference type="OrthoDB" id="105851at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="PTHR12746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMD3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="386" mass="45380" checksum="80ECBE6CFBCD07CE" modified="2011-05-03" version="1">MSERFCYRCGISESEGGPLIDGLCQVCFRKENPVLVMEDEINTELCQNCGSYKKKGVWVDPQNYELDQLIFEVAENALLENITLDERVREIRIVSREELNEIEELPVGVAYLSYEPVNWHIDYFPAIVIYEIEIKARIHELQRELHYEKKTVTVYVRQTVCPRCQKFLGGYFEAILQVRAEDRELTKEERDEIVKLVQEKVDEIMRRDRMGFIQDTVELEEGIDFYMGSTRSARKLAQAIRDRYGGTISEAYELVGLDRQTSKEVYRTSVSVRLPKFRKGDIVSDKNGNIYRVEEVNGKGMNLTNLSTHESEHKDWKTIKRERVELVEHERKEAMLTSLTPKEAQFMDMESYETFEIERPEIDLKEGEIYRLVKIKGKYYIESKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMF4</accession>
    <name>F0LMF4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ChlI-like cobalt chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_02203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468473.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02203"/>
    <dbReference type="EnsemblBacteria" id="ADT85177">
        <property type="protein sequence ID" value="ADT85177"/>
        <property type="gene ID" value="TERMP_02203"/>
    </dbReference>
    <dbReference type="GeneID" id="10042518"/>
    <dbReference type="KEGG" id="tba:TERMP_02203"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2198"/>
    <dbReference type="eggNOG" id="arCOG00438">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016684_5_0_2"/>
    <dbReference type="OMA" id="DTQMNYL"/>
    <dbReference type="OrthoDB" id="59101at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="470"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT85177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="637" mass="71578" checksum="32F8C23139F6DA11" modified="2011-05-03" version="1">MEPREKRLVFPFSAIVGQEKAKLALLCVAVNPLIGGVLLKGDKGTGKSTLVRALANVLPEIEVVDGCPFNCNPRNPLEMCDSCYERYERGEELPVAKRKMRVVDLPLSVTIDRLVGTVDVERFLKEGKKALQPGILAEANRNVLYIDEVNLLDDYIADSLLDAAAMGWNTIEREGISFRHPARFILIGSMNPEEGELRPQILDRFGLCVEVSAPMNPEERIEIVKRVEEFHEDPISFYKKFESEENKLTERVVKAREILPKIEISDDLLKLLAETVVNLGIKTNRAEIATIKTAKAIAALNGRRRVSLEDLEKAMELALPHRLRDKPFQKPPQMRPPKPKEDKEHNHDHKHNHKHEHKKEEKSESTRSQGIGNLEQNFRSSEAKIPRIESKNFGSNDFTGYRSSRDASVTVINFPRGVPVSYLPPTNGKIKDVDFYSSLVWAVLNGKKPPIRLDLKDVRVRVRKAKAPTLWVLLLDSSGSMAVQKRISIAKGIAEKLVENGYIKKSKVALIVAKGSQAEIFVPPTKNYLKVLDAIENVPTGGRTPLSSALYNLLLLAERERRKDKSLKVRAFLITDGKANVPLFGKRIKDEIIELAKALRRKEIELNIYDTRGGGINPGISYVSLLKEVAKAKVYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMH6</accession>
    <name>F0LMH6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pantothenate:Na+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_00979</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467253.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00979"/>
    <dbReference type="EnsemblBacteria" id="ADT83955">
        <property type="protein sequence ID" value="ADT83955"/>
        <property type="gene ID" value="TERMP_00979"/>
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    <dbReference type="KEGG" id="tba:TERMP_00979"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.982"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_15_2_2"/>
    <dbReference type="OMA" id="CWTDLIQ"/>
    <dbReference type="OrthoDB" id="8968at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:proline:sodium symporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0015824">
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    </dbReference>
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        <property type="entry name" value="SLC5sbd_PutP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Na/Glc_symporter_sf"/>
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        <property type="entry name" value="Na/Pro_symporter"/>
    </dbReference>
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        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
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        <property type="entry name" value="SSF"/>
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    </dbReference>
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        <location>
            <begin position="5"/>
            <end position="23"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
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        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="207"/>
        </location>
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        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
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        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
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        <location>
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            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="535" mass="57886" checksum="C5B5A4CDC766D499" modified="2011-05-03" version="1">MNAGILIGFLAYLALLAYIGWWANRFTKTEDQYFVGGRKVHILAAALSDKASDFSGWLMLGYPGSAFKAGLGAFWAAIGCLFGTLADYVLIGPRLRIYAGKFRAITVPDYLEARLKDDTKLIRILGAAIILVFMTAYVAAQFAAGGKALAQAFDISVNTGILITVIILTAYVITGGFFAVVWTDVVQALFMLLTLIIVPILALAKIGGLEKATQYMEPAKLHPFGGAVGFAALIFAIGYASWIVGYLGQPHIVTRYMSVEDPRKLRRPGIFISGIWTIIVLWGAFFAGFLGYAMVKAGILQVSDPERVIPAMAVELMPSWLAGFVIAGIISAIMSTADSQLLVASSAVTRDLYHKVLGKELGKKQIVNIGRIVVLGVAIFALYGALTGSKFIYGMVATAWGGLAVGFGPILTLSLWWKRVTKEAGIIGMAYGLISEVILESKIYGWAFNPNAPGFFGTLGSIFNGVPVFFINFFVTLFIIIIISLLTKPPEDVVKLHEQIFKKVPVQEGSKKVMEARAKSQIENVAEFIKARGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMH8</accession>
    <name>F0LMH8_THEBM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcaceae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00981"/>
    <dbReference type="EnsemblBacteria" id="ADT83957">
        <property type="protein sequence ID" value="ADT83957"/>
        <property type="gene ID" value="TERMP_00981"/>
    </dbReference>
    <dbReference type="GeneID" id="10041298"/>
    <dbReference type="KEGG" id="tba:TERMP_00981"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.984"/>
    <dbReference type="eggNOG" id="arCOG05783">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1640063_0_0_2"/>
    <dbReference type="OMA" id="VLYPYRI"/>
    <dbReference type="OrthoDB" id="81440at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="151" mass="18038" checksum="83513501CFAA0664" modified="2011-05-03" version="1">MGIATVKVMKPVFKPKDERNAKFVLYPYRIYHIKLFYKRLKMSDRVMDYFAYVDCYRFGVERGDGIIDIQEWKVPEDAIMPSNITKEEAKQKAVESAFNWGNLMVISWWTPKVEVVKEVEAYKVFWIFKEDEEVYVMDSLTGDKFKFKDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMJ7</accession>
    <name>F0LMJ7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01000"/>
    <dbReference type="EnsemblBacteria" id="ADT83976">
        <property type="protein sequence ID" value="ADT83976"/>
        <property type="gene ID" value="TERMP_01000"/>
    </dbReference>
    <dbReference type="GeneID" id="10041317"/>
    <dbReference type="KEGG" id="tba:TERMP_01000"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1003"/>
    <dbReference type="eggNOG" id="arCOG01686">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098528_0_0_2"/>
    <dbReference type="OMA" id="RMMEMAP"/>
    <dbReference type="OrthoDB" id="100166at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="217" mass="24317" checksum="9118A3A9C8B8278E" modified="2011-05-03" version="1">MEFETISVDDEKAKELAQILMNEKSLAILKLLQEKTLSLSEIARELDLPLSTVSYHIDKMLKVGLVEVAGKRYGKRLQEVKLYRASPKPILLLPRKMSVKERILRTFEKIQVISLSIAGLIAYGVYTLSKAAFAPAEQAPKVIKGEIMKNVTQTVAENVTQVMTIQRAPEATTTTTTVSTLQKAVTPQLAHLPHVIGIITFVILFLAFTRWFARRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMK1</accession>
    <name>F0LMK1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467278.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83980">
        <property type="protein sequence ID" value="ADT83980"/>
        <property type="gene ID" value="TERMP_01004"/>
    </dbReference>
    <dbReference type="GeneID" id="26136453"/>
    <dbReference type="KEGG" id="tba:TERMP_01004"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1007"/>
    <dbReference type="eggNOG" id="arCOG05826">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2152701_0_0_2"/>
    <dbReference type="OMA" id="VVESMSM"/>
    <dbReference type="OrthoDB" id="110783at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="110" mass="11945" checksum="17396FD6C8C01142" modified="2011-05-03" version="1">MLEILGFIFYAGAALVILFIGAFSGGISRILALPAAIGYMLLAFWSIEQVGSDIVSRGRNRDKRLMLALNIISFTLGAVAFYIYMESIATPALLLGPAFVIGLWKSYKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMV7</accession>
    <name>F0LMV7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoesterase</fullName>
            <ecNumber evidence="1">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467384.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01110"/>
    <dbReference type="EnsemblBacteria" id="ADT84086">
        <property type="protein sequence ID" value="ADT84086"/>
        <property type="gene ID" value="TERMP_01110"/>
    </dbReference>
    <dbReference type="GeneID" id="10041427"/>
    <dbReference type="KEGG" id="tba:TERMP_01110"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1113"/>
    <dbReference type="eggNOG" id="arCOG01143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074761_0_1_2"/>
    <dbReference type="OMA" id="DEYLFPW"/>
    <dbReference type="OrthoDB" id="82715at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="232" mass="26983" checksum="F4DAB54BF4E618F5" modified="2011-05-03" version="1">MLIGLISDIHSNWEALQAVWREVKKADVIFCMGDLVGYGANPNEVVEFFREQMKKREVLCVRGNHDNAVAFGMDWGFNPYARAAVRWHQQVMSIENLEFLRRLPIRQLFTDDTGRSYLIIHGSPRAPLDEYLFPWFPDSELKDVLSYVKQDDLIVGHTHMPMLREIDGRRIINPGGVGQPRDGDWRAAYAFIDTETREVIFERVEYDIDKAVRKIIEAGLPKFLAYRLYEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMW9</accession>
    <name>F0LMW9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="5" type="ordered locus">TERMP_01122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467396.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01122"/>
    <dbReference type="EnsemblBacteria" id="ADT84098">
        <property type="protein sequence ID" value="ADT84098"/>
        <property type="gene ID" value="TERMP_01122"/>
    </dbReference>
    <dbReference type="GeneID" id="10041439"/>
    <dbReference type="KEGG" id="tba:TERMP_01122"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1125"/>
    <dbReference type="eggNOG" id="arCOG04313">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_2"/>
    <dbReference type="OMA" id="KIVAMKM"/>
    <dbReference type="OrthoDB" id="106462at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="168" mass="19140" checksum="F1BF2D64F081DF15" modified="2011-05-03" version="1">MADNKVERTLVIIKPDAVVRGLIGEIISRFEKKGLKIVGMKMIHIDRELAERHYEEHKGKPFFNALIDYITKAPSVVMVVEGRYAISVVRKMAGATDPKDAEPGTIRGDLGLDVGDAIYNVVHASDSPESAEREINLYFKPEEIFEYSKAADWFYKTHWDKEKGEWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMX6</accession>
    <name>F0LMX6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Diphthami_syn_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467403.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01129"/>
    <dbReference type="EnsemblBacteria" id="ADT84105">
        <property type="protein sequence ID" value="ADT84105"/>
        <property type="gene ID" value="TERMP_01129"/>
    </dbReference>
    <dbReference type="GeneID" id="10041446"/>
    <dbReference type="KEGG" id="tba:TERMP_01129"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1132"/>
    <dbReference type="eggNOG" id="arCOG00035">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010289_0_2_2"/>
    <dbReference type="OMA" id="NYALYWA"/>
    <dbReference type="OrthoDB" id="101215at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="Alpha_ANH_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005237">
        <property type="entry name" value="MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022427">
        <property type="entry name" value="MJ0570_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="PTHR12196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039123">
        <property type="entry name" value="Diphthamide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03679">
        <property type="entry name" value="arCOG00187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00289">
        <property type="entry name" value="TIGR00289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthami_syn_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="225" mass="25802" checksum="A6DC7DE6035358D7" modified="2011-05-03" version="1">MKIATLFSGGKDSTYALYWAMQQGFDVKYLVSIHSKSEESYMYHVPNIHLTDLQAEAIGIPLIKGYTTGEKEKEVEDLKRVLEGLDIDGVVAGALESEYQRVRIERVCHELGLRSYTPLWHKNPEMLLRDMLHAGFEIVIVGVSAYGLDKKWLGRIVDEKAIEDLKELNRKYGIHIGGEGGEFETFVKDAPFFKARIVFDEVEKIWDEYTYSGVLVVKRAHLEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN43</accession>
    <name>F0LN43_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cold-shock DEAD-box protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_01196</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01196"/>
    <dbReference type="EnsemblBacteria" id="ADT84172">
        <property type="protein sequence ID" value="ADT84172"/>
        <property type="gene ID" value="TERMP_01196"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01196"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1199"/>
    <dbReference type="eggNOG" id="arCOG00558">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_2"/>
    <dbReference type="OMA" id="EHKDGQR"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="40"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="237"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT84172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="389" mass="44498" checksum="63B910A859EA6BEF" modified="2011-05-03" version="1">MLFGDKKMSFEKLGLSENTLGAVRRKGFSEPTDIQREVIPLFLRGDADIVGQSQTGTGKTASFALPLVDVINEYEREVQAIILTPTRELALQVADEIKSLRGKKRIKVLSVYGGQPIGPQIRALRKGAHIVVGTPGRVLDHIRRGTLRLDGIQYFILDEADRMLDMGFIDDIRAIFRETPRDKRVLMFSATMPREVLKLAKRYMKEYELIRTSSDEPVPNLVEQEYIEVVPARKISVLERILNSEFYGIVFCQTKRETRILAEKLARIGYSAEALNGDMSQKSRERALMRFKRRKINILVATDVAARGIDVQDITHIVNYSLPQNAEMYIHRIGRTGRAGKKGKAITFIMPGEYRRLRYIENIAKVSIKKSKLQESIDREKRRDSRKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN86</accession>
    <name>F0LN86_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747447.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02252"/>
    <dbReference type="EnsemblBacteria" id="ADT85225">
        <property type="protein sequence ID" value="ADT85225"/>
        <property type="gene ID" value="TERMP_02252"/>
    </dbReference>
    <dbReference type="GeneID" id="10549076"/>
    <dbReference type="KEGG" id="tba:TERMP_02252"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2246"/>
    <dbReference type="HOGENOM" id="CLU_1375577_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="198" mass="22746" checksum="FBF5280E2D9C9F7B" modified="2011-05-03" version="1">MKTEKILLVDSKIKDSLIKYLYRGSPPFEKIDELERLIKNALSRNEDPDVLANALSKLVQDEKELLLSGVLLFYHYKATSRRPKVYKPPLQKQSPEEKIQEFHIRGIEQIKNPMFNPTYRVKVNEEPSTTGDFAIIAVKAYYEHLQNSPVRILGLKKIGKKTFMVSTDLGEIRVDGNRPHAGYLYTPDGDIIKFIVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN95</accession>
    <name>F0LN95_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747456.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02261"/>
    <dbReference type="EnsemblBacteria" id="ADT85234">
        <property type="protein sequence ID" value="ADT85234"/>
        <property type="gene ID" value="TERMP_02261"/>
    </dbReference>
    <dbReference type="GeneID" id="10549085"/>
    <dbReference type="KEGG" id="tba:TERMP_02261"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2255"/>
    <dbReference type="eggNOG" id="arCOG07100">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1018123_0_0_2"/>
    <dbReference type="OrthoDB" id="134322at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024524">
        <property type="entry name" value="DUF3800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12686">
        <property type="entry name" value="DUF3800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="271" mass="32195" checksum="B82991A4F5DDF91E" modified="2011-05-03" version="1">MVEFIFSDEAGRIGVGNYYLRSVVVIPEKEYFEASNEFLSLKEEYGIPKDEELKTSDIWFLKICQEKNSPNLEKRCNKRLKKYLVDSKKGYEYYMEFLEKSLKLIPRSSVIIVVWTYFFERVFKNQRDIERDFLQTIMLRIEDELKEQGKRGIILYDVAFLKPLSRFYSEIFLRGEFVEKYSHIKDSIAFEVSTYSFGIQVADYISNIVLNALRGYKESRCLFIKYVRPKLRKKEAVSILRTGFIPLYLEHYRKGNLGESLIQKISWDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGU0</accession>
    <name>F0LGU0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NusA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466277.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00001"/>
    <dbReference type="EnsemblBacteria" id="ADT82979">
        <property type="protein sequence ID" value="ADT82979"/>
        <property type="gene ID" value="TERMP_00001"/>
    </dbReference>
    <dbReference type="GeneID" id="26137851"/>
    <dbReference type="KEGG" id="tba:TERMP_00001"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1"/>
    <dbReference type="eggNOG" id="arCOG05857">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2930392_0_0_2"/>
    <dbReference type="OMA" id="IIVYVPK"/>
    <dbReference type="OrthoDB" id="129050at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT82979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="59" mass="6554" checksum="46A272CD0C6E2E7F" modified="2011-05-03" version="1">MIERLKQMLRVEVIDVEYSGDRIIVYVPKDQVRIAVGSGGSAVKAAELVLGKKIEIRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGW0</accession>
    <name>F0LGW0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="8">HTPA synthase</shortName>
            <ecNumber evidence="4 8">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapA</name>
        <name evidence="9" type="ordered locus">TERMP_00021</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00021"/>
    <dbReference type="EnsemblBacteria" id="ADT82999">
        <property type="protein sequence ID" value="ADT82999"/>
        <property type="gene ID" value="TERMP_00021"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00021"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.20"/>
    <dbReference type="eggNOG" id="arCOG04172">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_5_1_2"/>
    <dbReference type="OMA" id="LPPMRYK"/>
    <dbReference type="OrthoDB" id="65776at2157"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT82999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="294" mass="32916" checksum="2C1A15F9F211BBEC" modified="2011-05-03" version="1">MIEGIFPPVVTPFKEDESIDEERFASFLEFLVKRKVSGLFLLGTNGEGLSLENEEKIRIMEIAVETVKGKVPVIAGTGAITTRETIKLSKEAERIGVDAIHVIVPYYYPLSREGILRHYAKVSQEVDLPILIYYIPSRTGNKIDVKMLCELAKLRNIIGIKDSSKDVTWFYNAIMAVKKENPDFVFLGGSDALIYTHLMLGGNGAVSAIANAFPEIVIELYREFRAGNLAKAKEIQDRILIIRQILKKYPYLSGIKAALKLRGIDMGVLRSPLVFLNEDQLQCLREELKAVGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGY9</accession>
    <name>F0LGY9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467495.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01221"/>
    <dbReference type="EnsemblBacteria" id="ADT84197">
        <property type="protein sequence ID" value="ADT84197"/>
        <property type="gene ID" value="TERMP_01221"/>
    </dbReference>
    <dbReference type="GeneID" id="10041538"/>
    <dbReference type="KEGG" id="tba:TERMP_01221"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1222"/>
    <dbReference type="eggNOG" id="arCOG03834">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139906_0_1_2"/>
    <dbReference type="OMA" id="WKENRYG"/>
    <dbReference type="OrthoDB" id="101306at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016645">
        <property type="entry name" value="UCP016134"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016134">
        <property type="entry name" value="UCP016134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="6"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="117" mass="14030" checksum="EA853DB93960B331" modified="2011-05-03" version="1">MKIYKLYVRDEYLEMIKSGKKKIEVRVAYPQIKGIKPKDKILFNDLVPAEVISVKRYETFRQVLREEPIEKIFPDNPSFEKALGRFHEMYPKWKENRYGVIAIKFHLLKPKSKGEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH11</accession>
    <name>F0LH11_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01243"/>
    <dbReference type="EnsemblBacteria" id="ADT84219">
        <property type="protein sequence ID" value="ADT84219"/>
        <property type="gene ID" value="TERMP_01243"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01243"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1245"/>
    <dbReference type="HOGENOM" id="CLU_3283046_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="40" mass="4663" checksum="33CDF35DA34A8516" modified="2011-05-03" version="1">MKVRKSKYPKSAANNNAGPKWKGVNGMFKVLQKVYNFYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH27</accession>
    <name>F0LH27_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4405 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01259"/>
    <dbReference type="EnsemblBacteria" id="ADT84235">
        <property type="protein sequence ID" value="ADT84235"/>
        <property type="gene ID" value="TERMP_01259"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01259"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1262"/>
    <dbReference type="eggNOG" id="arCOG04002">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2629903_0_0_2"/>
    <dbReference type="OMA" id="WSAMKAY"/>
    <dbReference type="OrthoDB" id="125501at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025517">
        <property type="entry name" value="DUF4405"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14358">
        <property type="entry name" value="DUF4405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4405" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="77" mass="8788" checksum="E41BF1AF87BFC2DB" modified="2011-05-03" version="1">MRMWVSLALFVTWLITGITGVILLVAPLAVQYGINLPVDTADTIHSYVGFMFFGLSFVHLALNWGAMKTYFRRMFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH70</accession>
    <name>F0LH70_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L10e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl10e</name>
        <name evidence="6" type="ordered locus">TERMP_00054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466330.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00054"/>
    <dbReference type="EnsemblBacteria" id="ADT83032">
        <property type="protein sequence ID" value="ADT83032"/>
        <property type="gene ID" value="TERMP_00054"/>
    </dbReference>
    <dbReference type="GeneID" id="26137907"/>
    <dbReference type="KEGG" id="tba:TERMP_00054"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.54"/>
    <dbReference type="eggNOG" id="arCOG04113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084051_0_2_2"/>
    <dbReference type="OMA" id="HHVIREN"/>
    <dbReference type="OrthoDB" id="82104at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00448">
        <property type="entry name" value="Ribosomal_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_L10e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022981">
        <property type="entry name" value="Ribosomal_L10e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_L10e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="PTHR11726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="5">
        <location>
            <begin position="14"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="180" mass="20953" checksum="1788208AFA71F3F3" modified="2011-05-03" version="1">MALRPAKIDRYVDKPAYTRREYIRGAPGPKITIFDMGNPAGDFEFEVSLHTAEPVQIRQNALEAVRIQVNRYLQKNVGRSNYHFKIRVYPFQVLRENPMATGRKADRYGNGMRRPFGKPIGLAARLKRDQKIVTVRVNRQHLKFALEAMRRAAMKFPCKCYYRIYDKQGNDITTKILSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH72</accession>
    <name>F0LH72_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine-glyoxylate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00056"/>
    <dbReference type="EnsemblBacteria" id="ADT83034">
        <property type="protein sequence ID" value="ADT83034"/>
        <property type="gene ID" value="TERMP_00056"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00056"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.56"/>
    <dbReference type="eggNOG" id="arCOG00082">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_1_1_2"/>
    <dbReference type="OMA" id="KNWLPIM"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="42"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="383" mass="43263" checksum="E4221809A9628042" modified="2011-05-03" version="1">MQMQFEDAYKEVYEIVKPRYKLFTAGPVACFPEVLEIMKVQMFSHRAKEYKVIHMDTLERLKKFLEAENGEIILFPSSGTGFMEAAVRNTVPRGGKVLVTIIGAFGKRFKEVVESNGRKAVTLEYEPGKAVKPEDLDDALRKNPDVHAVTITYNETSTGVLNPLPELAKVVNEHDKLLFVDAVSAMGGADIKFDKWGIDIIFGSSQKAFGVPPGLAIAAISQRVFEIAEKMPERGWYFDLPLYKKFNYKKQGTPSTPPMPQVFGLNVVLRIIEKMGGKEEWLKMYQKRAEMIRNGVREIGLEILAEPGYESPTITAVLTPEGIKGEEVYNAMRERGFELAKGYGEGIKEKTFRIGHMGYMTFEDIEEMLQNLKEVIEELKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHB8</accession>
    <name>F0LHB8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl14</name>
        <name evidence="5" type="ordered locus">TERMP_00102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466378.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00102"/>
    <dbReference type="EnsemblBacteria" id="ADT83080">
        <property type="protein sequence ID" value="ADT83080"/>
        <property type="gene ID" value="TERMP_00102"/>
    </dbReference>
    <dbReference type="GeneID" id="26135418"/>
    <dbReference type="KEGG" id="tba:TERMP_00102"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.103"/>
    <dbReference type="eggNOG" id="arCOG04095">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_3_0_2"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="OrthoDB" id="91632at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019971">
        <property type="entry name" value="Ribosomal_L14P_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03673">
        <property type="entry name" value="uL14_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="144" mass="15591" checksum="786C3A2B2A856587" modified="2011-05-03" version="1">MAKRGKKGAGATRGVSPVRPTRALPVGAYLKVADNSGAKVIQIIGVVEYHGVRRRLASAGVGDMVVATVKKGRPDMRHQVVRAVIVRQRKEYRRLDGMRVKFEDNAAVITTEDGVPRGTEIRGPIAREAAEKWVRLGGIASIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHD7</accession>
    <name>F0LHD7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467562.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01289"/>
    <dbReference type="EnsemblBacteria" id="ADT84264">
        <property type="protein sequence ID" value="ADT84264"/>
        <property type="gene ID" value="TERMP_01289"/>
    </dbReference>
    <dbReference type="GeneID" id="10041605"/>
    <dbReference type="KEGG" id="tba:TERMP_01289"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1291"/>
    <dbReference type="eggNOG" id="arCOG00985">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090468_1_1_2"/>
    <dbReference type="OMA" id="HDHIEIL"/>
    <dbReference type="OrthoDB" id="85279at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022430">
        <property type="entry name" value="CHP03684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="PTHR22798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03684">
        <property type="entry name" value="arCOG00985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="2">
        <location>
            <begin position="87"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="172" mass="19558" checksum="194C1C44856836AD" modified="2011-05-03" version="1">MLKIKHPLSKKEIKEIIREMSSIFGEEVAKKLISKKDNVQLAEFDKTTQILFVNGKPMFIKRQNLVFPLVIALYELSNEEDLRKWKRRVVVDEGAVPFILKGADVMAPGIVDADEDIKEGDFVFVVEENYGRPLAIGIALMSGRDMKEKNRGKAVKVIHHAKDKIWELTVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHF9</accession>
    <name>F0LHF9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467584.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01311"/>
    <dbReference type="EnsemblBacteria" id="ADT84286">
        <property type="protein sequence ID" value="ADT84286"/>
        <property type="gene ID" value="TERMP_01311"/>
    </dbReference>
    <dbReference type="GeneID" id="10041627"/>
    <dbReference type="KEGG" id="tba:TERMP_01311"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1312"/>
    <dbReference type="eggNOG" id="arCOG04842">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145818_0_0_2"/>
    <dbReference type="OMA" id="YGGMKIR"/>
    <dbReference type="OrthoDB" id="107998at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007154">
        <property type="entry name" value="DUF356"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04009">
        <property type="entry name" value="DUF356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006606">
        <property type="entry name" value="UCP006606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="134" mass="15418" checksum="2795C9EFEB50A1EF" modified="2011-05-03" version="1">MLNTIVLIRTDNFDKAMVALADLVRYGGMRIRGDPRIVPPALSDWAFEKIVGEKPRKRYRAHVVAQIDLPPAKAIGRLRDIHPPAHIIVIPPESPVHKELLRLWGTFEKLKGFHPPKVKRIEQKVEKEEGEEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHK7</accession>
    <name>F0LHK7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl30</name>
        <name evidence="4" type="ordered locus">TERMP_00113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466389.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00113"/>
    <dbReference type="EnsemblBacteria" id="ADT83091">
        <property type="protein sequence ID" value="ADT83091"/>
        <property type="gene ID" value="TERMP_00113"/>
    </dbReference>
    <dbReference type="GeneID" id="26135429"/>
    <dbReference type="KEGG" id="tba:TERMP_00113"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.114"/>
    <dbReference type="eggNOG" id="arCOG04086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055156_6_0_2"/>
    <dbReference type="OMA" id="KDYITWG"/>
    <dbReference type="OrthoDB" id="79065at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_A">
        <property type="entry name" value="Ribosomal_L30_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005997">
        <property type="entry name" value="Ribosomal_L30_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_L30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_L7/L30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_L7_euk_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="PTHR11524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01309">
        <property type="entry name" value="uL30_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="3">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="155" mass="17655" checksum="8ACD9449B61012AF" modified="2011-05-03" version="1">MAKIAIIRVRGRVGVKRPVKDTLAMLRLHKVNHLVIVDDTPSYKGMIQKAKDYITWGEINAETLAKLIRKRGRLIGNKRVTDEYVQEKLGMTIEEFAEKVISGEMKLSDLPNLKPVFRLHPPRGGFKGSKKRTFKEGGALGYRGEKINELIERML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHL3</accession>
    <name>F0LHL3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytidylate kinase</fullName>
            <shortName evidence="5">CK</shortName>
            <ecNumber evidence="5">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytidine monophosphate kinase</fullName>
            <shortName evidence="5">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cmk</name>
        <name evidence="6" type="ordered locus">TERMP_00119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytidylate kinase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00119"/>
    <dbReference type="EnsemblBacteria" id="ADT83097">
        <property type="protein sequence ID" value="ADT83097"/>
        <property type="gene ID" value="TERMP_00119"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00119"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.120"/>
    <dbReference type="eggNOG" id="arCOG01037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079959_1_0_2"/>
    <dbReference type="OMA" id="FIFRDMA"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00239">
        <property type="entry name" value="Cytidyl_kinase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011892">
        <property type="entry name" value="Cyt_kin_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02173">
        <property type="entry name" value="cyt_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="6"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="183" mass="21018" checksum="4390B9325A92E405" modified="2011-05-03" version="1">MITVSGLAGSGTTTLCRNIARHYGFKHIYAGLIFRQMAREMGMTLQEFQKYAELHPEIDREVDRRQVEAAKECNVVIEGRLAGWMVRNADLKIWLDAPIKVRAERVARREGISVEEAFMQIAEREKQNRKRYLNLYGIDINDLSIYDLVINTSKWSPDGVFAIVKAAIDHLYPDGDTGFRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHM5</accession>
    <name>F0LHM5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L18e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl18e</name>
        <name evidence="6" type="ordered locus">TERMP_00132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466407.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00132"/>
    <dbReference type="EnsemblBacteria" id="ADT83109">
        <property type="protein sequence ID" value="ADT83109"/>
        <property type="gene ID" value="TERMP_00132"/>
    </dbReference>
    <dbReference type="GeneID" id="26135448"/>
    <dbReference type="KEGG" id="tba:TERMP_00132"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.133"/>
    <dbReference type="eggNOG" id="arCOG00780">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146465_0_0_2"/>
    <dbReference type="OMA" id="WRLERPR"/>
    <dbReference type="OrthoDB" id="104254at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00329">
        <property type="entry name" value="Ribosomal_L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_L18/L18-A/B/e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_L18e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022947">
        <property type="entry name" value="Ribosomal_L18e_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="PTHR10934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="5">
        <location>
            <begin position="11"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="120" mass="13662" checksum="E1EDC908D936A4FA" modified="2011-05-03" version="1">MKRTGPTDINLRRLIRYLRKKSNEEGVKIWKDIAWRLERPRRQRAEVNVSKINRYTKEGDVVIVPGSVLGAGNLDHKVIVAAWKFSEKAKEKIINAGGEAITIEELIERNPKGSGVIIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHR0</accession>
    <name>F0LHR0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable Brix domain-containing ribosomal biogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably involved in the biogenesis of the ribosome.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466442.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00167"/>
    <dbReference type="EnsemblBacteria" id="ADT83144">
        <property type="protein sequence ID" value="ADT83144"/>
        <property type="gene ID" value="TERMP_00167"/>
    </dbReference>
    <dbReference type="GeneID" id="10040485"/>
    <dbReference type="KEGG" id="tba:TERMP_00167"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.168"/>
    <dbReference type="eggNOG" id="arCOG03247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107897_0_0_2"/>
    <dbReference type="OMA" id="VKIWIME"/>
    <dbReference type="OrthoDB" id="61656at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00699">
        <property type="entry name" value="BriX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023548">
        <property type="entry name" value="Brix_dom_Rbsml_bgen_prot"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="3">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="212" mass="24848" checksum="01DBC866FEE75056" modified="2011-05-03" version="1">MMLITTSHRPTRRTRSFGHDLERVFPNSTYLTRGKKTIQDLLMEAYDRGYERLLIINVWKGNPLKMTFIKVSPDDWGYLGYLYLHGIKLQREIGFRNIRPIREEMPFIVTTAKRVGLDHIAFAQAFAELTNGKFIPRGDKSLTYIADKYNTDVLGVIERHPRGMAINFYRLDITKERPVGPLISVKIWIMEDGRRWDYKEALGIKVKRREGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHR2</accession>
    <name>F0LHR2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prefoldin subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">GimC subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pfdB</name>
        <name evidence="9" type="ordered locus">TERMP_00169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466444.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00169"/>
    <dbReference type="EnsemblBacteria" id="ADT83146">
        <property type="protein sequence ID" value="ADT83146"/>
        <property type="gene ID" value="TERMP_00169"/>
    </dbReference>
    <dbReference type="GeneID" id="26135501"/>
    <dbReference type="KEGG" id="tba:TERMP_00169"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.170"/>
    <dbReference type="eggNOG" id="arCOG01342">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131909_1_1_2"/>
    <dbReference type="OMA" id="PPQVQAM"/>
    <dbReference type="OrthoDB" id="116327at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00307">
        <property type="entry name" value="PfdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012713">
        <property type="entry name" value="PfdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02338">
        <property type="entry name" value="gimC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="8"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="116" mass="13334" checksum="5466F0A2758B9A32" modified="2011-05-03" version="1">MQNIPPQVQALLGQLESYQQQLQLVIQQKQKVQVDLNDAKKALEEIEKVEENTPIYKTVGTLIVKTSKNKAVEELKEKIETLEVRLNALNRQEQKLNEKIKELTQKIQSMLRPTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHR5</accession>
    <name>F0LHR5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466447.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00172"/>
    <dbReference type="EnsemblBacteria" id="ADT83149">
        <property type="protein sequence ID" value="ADT83149"/>
        <property type="gene ID" value="TERMP_00172"/>
    </dbReference>
    <dbReference type="GeneID" id="10040490"/>
    <dbReference type="KEGG" id="tba:TERMP_00172"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.173"/>
    <dbReference type="eggNOG" id="arCOG02123">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151247_1_0_2"/>
    <dbReference type="OMA" id="YYAMFYA"/>
    <dbReference type="OrthoDB" id="118985at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="135" mass="15935" checksum="51CA6E17C0F963BC" modified="2011-05-03" version="1">MHEFEEYLQKAHEKLKATEILLSNGFYEDAISRAYYAMFYAARALLSTKNIYPKTHRGIVQKFGLEFVSKGLIEGFYAKALIAVQERRERADYDIYYIPTFEEAKEIFETAQRFVKRVEQAISEMVKNNERQNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHW1</accession>
    <name>F0LHW1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467659.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01386"/>
    <dbReference type="EnsemblBacteria" id="ADT84361">
        <property type="protein sequence ID" value="ADT84361"/>
        <property type="gene ID" value="TERMP_01386"/>
    </dbReference>
    <dbReference type="GeneID" id="10041702"/>
    <dbReference type="KEGG" id="tba:TERMP_01386"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1386"/>
    <dbReference type="eggNOG" id="arCOG02702">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1140608_0_0_2"/>
    <dbReference type="OMA" id="DVYCEVG"/>
    <dbReference type="OrthoDB" id="71303at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="74"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="243" mass="27868" checksum="E2FFE77010EA916D" modified="2011-05-03" version="1">MIPSIEEIRTFLEKLGFGEGEVNELVEQIEYFETEAPERDDIVRDYLRDECIETIVNDIVGEILKLNRKDIRLLDVAAGSGFFTERVRRKLEEKGIKVQVYGFDITPSMLKRLKEKGITPIWGVAEKIRESIMIANEHYGINVPKEFDVVLSTLAFHHFLKPEEVLRSMKSVLKEGGKVIIVDVLKHEHEEFKETLKDTHLGFSLEEIKGMGSRVFKKVEAGYMDVYCEVGDIIVGLYKAVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHX1</accession>
    <name>F0LHX1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467669.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01396"/>
    <dbReference type="EnsemblBacteria" id="ADT84371">
        <property type="protein sequence ID" value="ADT84371"/>
        <property type="gene ID" value="TERMP_01396"/>
    </dbReference>
    <dbReference type="GeneID" id="10041712"/>
    <dbReference type="KEGG" id="tba:TERMP_01396"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1396"/>
    <dbReference type="eggNOG" id="arCOG09748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_449523_0_0_2"/>
    <dbReference type="OMA" id="YGRPERY"/>
    <dbReference type="OrthoDB" id="18620at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="607" mass="72091" checksum="5FDF0A2983410B08" modified="2011-05-03" version="1">MVVFNEGNPECVRNLLRPAERVLRQGRDVTVEDFETRKSLWERIQDSYSRYLEGECGDFLRDLDSTFRAKFEAALAVLAWSFWKKGEAFPPAEKSFSEREIGLIDEILKYNVFEITTMEDILEKLYRRDEETLQLLKTYYLGVDRWIEEQLEDPEIKLPLRYYLKRTWKSYREKIDAAINEASKYGWFRTLMEEWEREKTEEVEAVRESYEARVGELKKRIAEMVEFFEEERRKLEEELSASSLEEVERLRREKEELIERFEREKAELARRLTELKDEELRKKLEEELARAKEEALREARLLEEKLRRRELELREKEMELRKRELELSEKENLLKSRIEEILAMSGKVEKGSRLVLRDEARIGELNFVGRMKSKFAGEVRLLGRTYSVERIEEKKGEDTARFAGKLDEKSLKNLPENRYVEVALKEKKLLGRKERILVRGVYLTRVERLAELGLDTDPLTLAEVNVHLIDARDSKENARTILVIASPLGFEERVRRYVSSEDFHRNFYSENVSLILLDTESGEVIHNPNDRYAKALVPLVRLELDEEIYARVRECVRKKLEGRDYLPLSECLDCGDEEYVRRAFYEIAREGNLVKYIDGFGLVLIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHZ1</accession>
    <name>F0LHZ1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01416"/>
    <dbReference type="EnsemblBacteria" id="ADT84391">
        <property type="protein sequence ID" value="ADT84391"/>
        <property type="gene ID" value="TERMP_01416"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01416"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1416"/>
    <dbReference type="eggNOG" id="arCOG02008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100105_0_0_2"/>
    <dbReference type="OMA" id="IGIYHEG"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="177" mass="19575" checksum="09AE6F90F777E425" modified="2011-05-03" version="1">MMRHLKYLGIAGVVVYWLFVAWSIGKNPWFSFWRNALSDLGSPEMAQAPGIYNYGLMVTAVFMLAFSVYLMFSAENKLGTIGGAYISISAIFLALIGVFHAGTRPHGFVSTYFFVQFFLGMLIYGAGSKNRAIRYGSVALFALALLGTFVHWPSVALIETYEIALIAVFTSLIAIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI00</accession>
    <name>F0LI00_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF302 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467698.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01425"/>
    <dbReference type="EnsemblBacteria" id="ADT84400">
        <property type="protein sequence ID" value="ADT84400"/>
        <property type="gene ID" value="TERMP_01425"/>
    </dbReference>
    <dbReference type="GeneID" id="26136921"/>
    <dbReference type="KEGG" id="tba:TERMP_01425"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1425"/>
    <dbReference type="eggNOG" id="arCOG02761">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126998_1_1_2"/>
    <dbReference type="OMA" id="NQDMPPY"/>
    <dbReference type="OrthoDB" id="98045at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016796">
        <property type="entry name" value="UCP021774"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021774">
        <property type="entry name" value="UCP021774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="SSF103247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="1">
        <location>
            <begin position="36"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="117" mass="13934" checksum="26BF597E72AC1901" modified="2011-05-03" version="1">MFRYRKKVGLSFEEAEKKFKEELKKRGYKVVLEMNASEVIKRNVGAEFEPYKIFYICNPKVFYEMTKREYEIGSFAPCPVILYKKEDNVYFAINTAEEVLDIIREPLEVVKDTLKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI10</accession>
    <name>F0LI10_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aspartate carbamoyltransferase regulatory chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrI</name>
        <name evidence="10" type="ordered locus">TERMP_01435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in allosteric regulation of aspartate carbamoyltransferase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Contains catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PyrI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467708.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01435"/>
    <dbReference type="EnsemblBacteria" id="ADT84410">
        <property type="protein sequence ID" value="ADT84410"/>
        <property type="gene ID" value="TERMP_01435"/>
    </dbReference>
    <dbReference type="GeneID" id="10041751"/>
    <dbReference type="KEGG" id="tba:TERMP_01435"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1435"/>
    <dbReference type="eggNOG" id="arCOG04229">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128576_0_0_2"/>
    <dbReference type="OMA" id="CPNRNCI"/>
    <dbReference type="OrthoDB" id="101957at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009347">
        <property type="term" value="C:aspartate carbamoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00002">
        <property type="entry name" value="Asp_carb_tr_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020545">
        <property type="entry name" value="Asp_carbamoyltransf_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002801">
        <property type="entry name" value="Asp_carbamoylTrfase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020542">
        <property type="entry name" value="Asp_carbamoyltrfase_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036792">
        <property type="entry name" value="Asp_carbatrfase_reg_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036793">
        <property type="entry name" value="Asp_carbatrfase_reg_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805">
        <property type="entry name" value="PTHR35805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01948">
        <property type="entry name" value="PyrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02748">
        <property type="entry name" value="PyrI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54893">
        <property type="entry name" value="SSF54893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57825">
        <property type="entry name" value="SSF57825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00240">
        <property type="entry name" value="ATCase_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PyrI" evidence="8">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PyrI_C" evidence="9">
        <location>
            <begin position="100"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT84410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="151" mass="16872" checksum="84619BAEAAFE70FC" modified="2011-05-03" version="1">MSELKVSAIKEGTVIDHIPAGKGLKVIEILNLDALNGGTVLLAMNVHSKKLGRKDIVKVEGKYLSEEEVNKIALIAPTATVNIIRDYRVAEKFNVEVPEKISGILRCANPNCISNHEYVVPKFYVISKEPLKVRCHYCERTMEEEEILANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI33</accession>
    <name>F0LI33_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466485.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00210"/>
    <dbReference type="EnsemblBacteria" id="ADT83187">
        <property type="protein sequence ID" value="ADT83187"/>
        <property type="gene ID" value="TERMP_00210"/>
    </dbReference>
    <dbReference type="GeneID" id="26135539"/>
    <dbReference type="KEGG" id="tba:TERMP_00210"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.210"/>
    <dbReference type="eggNOG" id="arCOG01963">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104481_0_0_2"/>
    <dbReference type="OMA" id="IRKIMHD"/>
    <dbReference type="OrthoDB" id="90144at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="102"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="197" mass="22369" checksum="E8D25A9CB99CAC1F" modified="2011-05-03" version="1">MKELEEIKDCLVEMKNLSSLMVDLAFSSVMYNSEDIADEVYILEEKMDELTLKVKKLALRAAKNESDPEKLLSIIEMATINEQISDSAYEIADLILRDVEPHPIIRKIMHDVEEEIGRVKVNKGSILIGKSLKQLKLPTKIGVRLIAIKRGSKYIYNPNKDEEIKEGDILIAVGSGIDRLRELSNEKGEEGERIEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI58</accession>
    <name>F0LI58_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466510.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00235"/>
    <dbReference type="EnsemblBacteria" id="ADT83212">
        <property type="protein sequence ID" value="ADT83212"/>
        <property type="gene ID" value="TERMP_00235"/>
    </dbReference>
    <dbReference type="GeneID" id="10040553"/>
    <dbReference type="KEGG" id="tba:TERMP_00235"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.235"/>
    <dbReference type="eggNOG" id="arCOG01150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075478_0_1_2"/>
    <dbReference type="OMA" id="GNHDTML"/>
    <dbReference type="OrthoDB" id="105276at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004376">
        <property type="entry name" value="CHP00024_Pesterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024173">
        <property type="entry name" value="Pesterase_MJ0037"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30337:SF5">
        <property type="entry name" value="PTHR30337:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000887">
        <property type="entry name" value="Pesterase_MJ0037"/>
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    </dbReference>
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        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SbcD_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="18"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="226" mass="25789" checksum="223B3C7550976A45" modified="2011-05-03" version="1">MRPQPLPNKALKIGNNIIIADLHLGYEESLAREGAYLPKAFHEMISSLKTMLQKEKPKRLIINGDLKHSFIPFRREKLELKAFFEEISPLVNEIVVVKGNHDVGIVWIKELGVEAVDELEISGWKIVHGHKIVEGNKFIIGHEHPAIRLRDEVGALIKAPIFLLSEELIVLPAFTPWAYGNDILREIVSPFLLKFNIEDAEVVVPIEDELLNFSTMKQLREVLRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIB6</accession>
    <name>F0LIB6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-quinone oxidoreductase chain I</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">TERMP_01471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01471"/>
    <dbReference type="EnsemblBacteria" id="ADT84446">
        <property type="protein sequence ID" value="ADT84446"/>
        <property type="gene ID" value="TERMP_01471"/>
    </dbReference>
    <dbReference type="GeneID" id="26136959"/>
    <dbReference type="KEGG" id="tba:TERMP_01471"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1471"/>
    <dbReference type="eggNOG" id="arCOG01543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_4_6_2"/>
    <dbReference type="OMA" id="MEWIPEL"/>
    <dbReference type="OrthoDB" id="108931at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="152" mass="17302" checksum="F5E180F62555B21C" modified="2011-05-03" version="1">MPTKAMFLFLKQLMERPFTNPFPVKHAPKNVTALIDKVQRGEAKINPPVPVPEGFRGKLKYTPERCIGCRLCILVCPANAMEWIPELKKIRHYVSRCMFCALCVDVCPGKKFPGEEKAVKALRMSDEFLLADYNKYSDNLIEEPPEAKEMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LII9</accession>
    <name>F0LII9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00286"/>
    <dbReference type="EnsemblBacteria" id="ADT83263">
        <property type="protein sequence ID" value="ADT83263"/>
        <property type="gene ID" value="TERMP_00286"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00286"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.286"/>
    <dbReference type="eggNOG" id="arCOG03655">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171553_0_0_2"/>
    <dbReference type="OMA" id="PHMVREI"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="92" mass="10712" checksum="DE5BE6E720DDE225" modified="2011-05-03" version="1">MARILENVKYFIKGFISAFKQQSTEYLEFEERELENVFALLLMGAFVGIPSPPTTLVMRLMPHMVREIYVMQQRAINMDDIFGEMAALFEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIJ3</accession>
    <name>F0LIJ3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466565.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00290"/>
    <dbReference type="EnsemblBacteria" id="ADT83267">
        <property type="protein sequence ID" value="ADT83267"/>
        <property type="gene ID" value="TERMP_00290"/>
    </dbReference>
    <dbReference type="GeneID" id="10040608"/>
    <dbReference type="KEGG" id="tba:TERMP_00290"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.290"/>
    <dbReference type="eggNOG" id="arCOG01940">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_3_0_2"/>
    <dbReference type="OMA" id="AVWKHIE"/>
    <dbReference type="OrthoDB" id="42041at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="8"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="249" mass="27970" checksum="0E0241F8CED14208" modified="2011-05-03" version="1">MLDINTEIIGRKVIYLQEVESTNELAKKIAPQEEEGTIIVADIQRRGRGRKLRKWISPKGGLWMSVILKPNVHLVHITKLVFVSALAVVETLAEFGIEGKIKWPNDVLVNRKKICGILSEGKYSTDSVEYVVLGIGLNVNNEIPVDLLDVAISMKDVLGFRVPLVEVFRNLLEKLDKWYLRYLDGQYALILEEWKAYSAVIGKEVRIVGDNEEIIGTAVDVSDDGSLIIALKDGTLKKIYYGDVSLRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIK8</accession>
    <name>F0LIK8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466580.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00305"/>
    <dbReference type="EnsemblBacteria" id="ADT83282">
        <property type="protein sequence ID" value="ADT83282"/>
        <property type="gene ID" value="TERMP_00305"/>
    </dbReference>
    <dbReference type="GeneID" id="10040623"/>
    <dbReference type="KEGG" id="tba:TERMP_00305"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.305"/>
    <dbReference type="eggNOG" id="arCOG01096">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065373_0_0_2"/>
    <dbReference type="OMA" id="EMGENSA"/>
    <dbReference type="OrthoDB" id="26612at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01044">
        <property type="entry name" value="Ferritin_CCC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039376">
        <property type="entry name" value="Ferritin_CCC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Rubrerythrin" evidence="6">
        <location>
            <begin position="14"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="364" mass="40850" checksum="8F9BB3395D8F37C7" modified="2011-05-03" version="1">MDEMIKSALQFYEDEYSDSILYAQLAKTEKDESLKKEFLRLSNIEAKHAKFWHDFLTRRNVRTPRIKISKLSLYSIRLLRKILGPGAVASLLEMGENSAIQKYFKFLTTYQEKLNDEERRELSDVILDELEHEKFFYESKKRLHVENIRDLVLGMNDGLVEILGAVTGLSAVYVYNPKLVGISGLIVGVAGALSMAIGTFISVRSQRQVNESIRQRMEVLFRVSPDRAKDELLDKLLESGMPENVAKEVAEKLSSNHDAIIKLLIQEEDENEIRAALYTGCFYLLGVAFPVTPYFFASSSLVALPFSVLLAGTALAVVATFISVLSGISIKKKVTEMVTTGLGAAFVSYLFGHLMEALFHVSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIK9</accession>
    <name>F0LIK9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trm1</name>
        <name evidence="9" type="ordered locus">TERMP_00306</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466581.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00306"/>
    <dbReference type="EnsemblBacteria" id="ADT83283">
        <property type="protein sequence ID" value="ADT83283"/>
        <property type="gene ID" value="TERMP_00306"/>
    </dbReference>
    <dbReference type="GeneID" id="10040624"/>
    <dbReference type="KEGG" id="tba:TERMP_00306"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.306"/>
    <dbReference type="eggNOG" id="arCOG01219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010862_5_1_2"/>
    <dbReference type="OMA" id="VFYNPVM"/>
    <dbReference type="OrthoDB" id="70865at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004809">
        <property type="term" value="F:tRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00290">
        <property type="entry name" value="tRNA_dimethyltr_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022923">
        <property type="entry name" value="TRM1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="PTHR10631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="379" mass="43224" checksum="6F0BC5C37FB9F22A" modified="2011-05-03" version="1">MELIEISEGKARVLVPKAERIYDAPVFYNPVMALNRDLSVLLLKVVKPKKVLDALSATGIRGIRYALETPAAEVWMNDINPDAFELIIKNLALNFPGKIEIHEKRAFLKGSKVLVATNLDANRLMNDQFRYFDFIDLDPFGSPMEFLDSALRSVKRKGVLAITATDTAPLCGAHPKACLRKYNAVPIRGELCHEAGLRILIGTVARYVAKYDMGFEVLFAYYKDHYFRAFLRFKDGAKKGDETLEKLGYLYFNEKNGKFEIERSFLPSKAKAYGPLWLGELKNQEIVEEIHKLAEREEIAEKKKVLKFLGIIKEELDVPFFYDTHALARRNNLEARKVSKIIEILKEEGYKATRTHFSPTALKTDAPFEKVLETLKSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIU7</accession>
    <name>F0LIU7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467847.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01574"/>
    <dbReference type="EnsemblBacteria" id="ADT84549">
        <property type="protein sequence ID" value="ADT84549"/>
        <property type="gene ID" value="TERMP_01574"/>
    </dbReference>
    <dbReference type="GeneID" id="10041890"/>
    <dbReference type="KEGG" id="tba:TERMP_01574"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1574"/>
    <dbReference type="eggNOG" id="arCOG01679">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03045">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_367490_0_0_2"/>
    <dbReference type="OMA" id="FGDAFWY"/>
    <dbReference type="OrthoDB" id="15659at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="PTHR23155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="581"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="519"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="755" mass="87713" checksum="8DFEE0BD2A60D53F" modified="2011-05-03" version="1">MNASSLIKLLSNETNLEILSVLRSGSFNPRELARILGRDETDVSRRLRAMERAGLVEGRWMRVRGKNVKVYSLKVEDIRIRFEPGEILVSTSKGDRYEVPLLESRHPLVDIFVGREKEIDLITSSEKSVIVIYGIAGIGKTALAAKIFGDAFWYQMSEGDSLDYFAWQVGLFLNSLGYDALLEYLRAGGREERDIFELLLDGVEKSSAKIVIDDLHKCRDERILHLLAFLSEKLDKGKLVVTSREKPNLGLNALYLRLSGLSLEEAYSLVEAKGVNISPEEFVKVYQMTLGHPLALNLFSETYVERREFERENLFDFLVNEIYEKLKTDERFLLQFMSLFDEPLEYDEIKELYGKNVFSVLYSLLNKGLIERRGNLYFVHDLIRGFLSEVREVDEAKFYSKYIKFLLKKNNTRDFLKAFRYAVKLKDEKTIKRLVELRLRRFKRVVQDFSDSYLNVLSTIKDNPYAKEELASIYFQKGFFEKALKLWLEIKDELEGIHKADVLSSLVDVYIELNKSDESKKYLRELEKMREIMNDAEVDFWYFVELTKLNAYLGKLEDALESAFNELGALKRLNPYPELESLVLLHIGDIYIELERYRESLKYYSQALDLARAYSLSFMEHLSLSELSKAYYLVENYKKAVEHATEAVDYFLKVRNYRRAVDALAYRCFSYIALGELEMAQKDAEEMIRIAQSTGYPLGWAGYIALAAVENLRGGNFKEYINIGRERLKGYPWLYEVVLEELSRIFDISSITAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIX7</accession>
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        <submittedName>
            <fullName evidence="2">Rubrerythrin</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
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            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466621.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00346"/>
    <dbReference type="EnsemblBacteria" id="ADT83323">
        <property type="protein sequence ID" value="ADT83323"/>
        <property type="gene ID" value="TERMP_00346"/>
    </dbReference>
    <dbReference type="GeneID" id="10040664"/>
    <dbReference type="KEGG" id="tba:TERMP_00346"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.346"/>
    <dbReference type="eggNOG" id="arCOG01102">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1381484_0_0_2"/>
    <dbReference type="OMA" id="LMKDINF"/>
    <dbReference type="OrthoDB" id="82551at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="174" mass="20840" checksum="A2293447F9A70F6E" modified="2011-05-03" version="1">MKITDKEVFEIAVNSEIRTKEMYEKLASLVKSDLIKDELMFLANEEDKHRRIVEKIREKLGSEETEPKKIDIEIIDEFKVIAEKMGDAIQKQDTEITEVYEIAMQAELVSEKLYKELARYAATEKTKLLLEMLADMEKNHYNILKKQYEYITRYPEIYKEEFYDQLMKDINFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ01</accession>
    <name>F0LJ01_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466645.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00370"/>
    <dbReference type="EnsemblBacteria" id="ADT83347">
        <property type="protein sequence ID" value="ADT83347"/>
        <property type="gene ID" value="TERMP_00370"/>
    </dbReference>
    <dbReference type="GeneID" id="10040688"/>
    <dbReference type="KEGG" id="tba:TERMP_00370"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.370"/>
    <dbReference type="eggNOG" id="arCOG07495">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203781_1_0_2"/>
    <dbReference type="OMA" id="KRCYYAP"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="59" mass="6604" checksum="78C02659540F7A4E" modified="2011-05-03" version="1">MSNEEVVLEVMKKAGKPLKSAEIAEMTGIPKKEVDKIIKKLKKEGKIVSPKRCYYAPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ03</accession>
    <name>F0LJ03_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466647.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00372"/>
    <dbReference type="EnsemblBacteria" id="ADT83349">
        <property type="protein sequence ID" value="ADT83349"/>
        <property type="gene ID" value="TERMP_00372"/>
    </dbReference>
    <dbReference type="GeneID" id="10040690"/>
    <dbReference type="KEGG" id="tba:TERMP_00372"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.372"/>
    <dbReference type="eggNOG" id="arCOG00022">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119369_0_0_2"/>
    <dbReference type="OMA" id="IFHKELM"/>
    <dbReference type="OrthoDB" id="89019at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="187" mass="21755" checksum="04077EEBD5BB0A08" modified="2011-05-03" version="1">MEGLIGIVEKTRKLEEKAEKEYRKSLKKLKEPEYADIKNLLLRITIDTILHKNMLEAVKKSYEDALKLIEEFEGEEIADNTVLIPGVPMIAMPLDFGTLGARIPPEEILEEYFKEFPETAVIPEEKLNEIRDIIKEYLRLQEEMATLYGKLKEKVTHPILKTLMESTENNEKQHEKLLKKLAQKYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ11</accession>
    <name>F0LJ11_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466655.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00380"/>
    <dbReference type="EnsemblBacteria" id="ADT83357">
        <property type="protein sequence ID" value="ADT83357"/>
        <property type="gene ID" value="TERMP_00380"/>
    </dbReference>
    <dbReference type="GeneID" id="10040698"/>
    <dbReference type="KEGG" id="tba:TERMP_00380"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.380"/>
    <dbReference type="eggNOG" id="arCOG01879">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1369577_0_0_2"/>
    <dbReference type="OMA" id="IMFSAMA"/>
    <dbReference type="OrthoDB" id="87824at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="201" mass="22919" checksum="6AE869042FD1E03A" modified="2011-05-03" version="1">MLKYLAVGVMFPVLAILFTKYLGEEYAWINRKIIHFSSVPAILFFREGLVTGKELAAVVMLFAFGQLLTHLMNKELSWYQIKNNYGEVFYCIMFSAMALFMDVNYASAIMLVMAVSDGITGVLRFYYFKKNGFNVKLRKHWIGSVGYIVSAVIIAFLILPQLNFLMKIAWSIILMLAEYQKVIDDNVAVPVVAVLIKPLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ15</accession>
    <name>F0LJ15_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466659.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00384"/>
    <dbReference type="EnsemblBacteria" id="ADT83361">
        <property type="protein sequence ID" value="ADT83361"/>
        <property type="gene ID" value="TERMP_00384"/>
    </dbReference>
    <dbReference type="GeneID" id="25394624"/>
    <dbReference type="KEGG" id="tba:TERMP_00384"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.384"/>
    <dbReference type="eggNOG" id="arCOG02271">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2505122_0_0_2"/>
    <dbReference type="OrthoDB" id="78391at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="85" mass="10240" checksum="65D1254D0101EF4F" modified="2011-05-03" version="1">MKRIKFKVPLNQEMFEMFRGFPEAVEWGYGDTYFILDDEVVKITEVKFREDVSPEEIIGSLRKLHYIKRAQDHTKERPPHNLQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ27</accession>
    <name>F0LJ27_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00396"/>
    <dbReference type="EnsemblBacteria" id="ADT83373">
        <property type="protein sequence ID" value="ADT83373"/>
        <property type="gene ID" value="TERMP_00396"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00396"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.396"/>
    <dbReference type="eggNOG" id="arCOG04479">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162441_0_0_2"/>
    <dbReference type="OMA" id="LVAPPEC"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038767">
        <property type="entry name" value="Transcriptional_reg_pdt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40663">
        <property type="entry name" value="PTHR40663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="96" mass="11147" checksum="8C2295E06027A881" modified="2011-05-03" version="1">MTRRQKIIKLLEERDYSVSELATMLDMRGKGSKKAVLEDLKAVAKIVRREGKVLLIQPAICRKCGFVFRAEINIPSKCPKCKSQWIEEPRFKIEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ43</accession>
    <name>F0LJ43_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="5" type="ordered locus">TERMP_00412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466687.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00412"/>
    <dbReference type="EnsemblBacteria" id="ADT83389">
        <property type="protein sequence ID" value="ADT83389"/>
        <property type="gene ID" value="TERMP_00412"/>
    </dbReference>
    <dbReference type="GeneID" id="10040730"/>
    <dbReference type="KEGG" id="tba:TERMP_00412"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.412"/>
    <dbReference type="eggNOG" id="arCOG00455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_1_2_2"/>
    <dbReference type="OMA" id="VVRVMTN"/>
    <dbReference type="OrthoDB" id="70966at2157"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="150"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="260" mass="28208" checksum="312EB1415031C8A4" modified="2011-05-03" version="1">MKIAVIGAGTVGSAVAKALSEKYEVIATRRRIEKVRWLEKHGVKLMKDNKAAAEVADVIILTVKPNKVRKVLEEIREVVKGKIVISFAAGIPLKVLKSSADAKFVRAMPNIAILVKESFTAYATNDLSDEEIKLVEEIFETFGKCIKIEEEYMDAITGLSGSGPAYASVFLESLIYGGLKVGLPRDVALLAAAQTLLGTAKLLLETNLHPAQIRDMVITPGGTTIDGIFELEDSRVRTAIMKAVDAATKKSKILSLEINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ44</accession>
    <name>F0LJ44_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466688.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00413"/>
    <dbReference type="EnsemblBacteria" id="ADT83390">
        <property type="protein sequence ID" value="ADT83390"/>
        <property type="gene ID" value="TERMP_00413"/>
    </dbReference>
    <dbReference type="GeneID" id="10040731"/>
    <dbReference type="KEGG" id="tba:TERMP_00413"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.413"/>
    <dbReference type="eggNOG" id="arCOG00494">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_1_0_2"/>
    <dbReference type="OMA" id="WPEMVDN"/>
    <dbReference type="OrthoDB" id="26718at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="328" mass="36659" checksum="23FE4D1F9FF00663" modified="2011-05-03" version="1">MEVAILGATGLVGQIFVRLLENHPWFKIERLVASERSKGKKYREIAEWVSDDTGDIEVESLEDFLKNPDVDLVFSALPSSIAGKVEEKLAEKIPVFSNASSHRYEDDVPILVPEVNADQLKLIEFQQEQRGWEGFIVTNPNCSTAILMLSLKVLSEFGLKKVNVATMQAISGAGFKGLSALQIFDNVIPYIEKEEWKIENESRKILGFDFEMSAITTRVPVSHGHTEAVFVELSEDISVEELRKAFDSFDPLKKLKLPSYAKPIVYKEIPQPKLHRKLGNGMTVTVGRLEKIGKKKFKYVTLGHNLVRGAAGGSILNAELSYRLGVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ67</accession>
    <name>F0LJ67_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467887.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01614"/>
    <dbReference type="EnsemblBacteria" id="ADT84589">
        <property type="protein sequence ID" value="ADT84589"/>
        <property type="gene ID" value="TERMP_01614"/>
    </dbReference>
    <dbReference type="GeneID" id="10041930"/>
    <dbReference type="KEGG" id="tba:TERMP_01614"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1614"/>
    <dbReference type="eggNOG" id="arCOG05721">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024709_0_0_2"/>
    <dbReference type="OMA" id="YWGHGSG"/>
    <dbReference type="OrthoDB" id="31522at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="361" mass="39370" checksum="3496460EB01CF882" modified="2011-05-03" version="1">MKAPDLGIKIGFYEHGKRNSITDVKGIKVGHVTLIKGEGKLVPGKGPVRTGVTVILPHDGNIFKEKLLASVFVMNGYAKPVGLTQIRELGTLETPIALTNTLSVYTVADALTDYMLEQNEDIGVTTGSVNPVVLECNDSYLNDLRGKHVKKEHVFEAIKNASEDFEEGSVGAGTGMSSFEFKGGIGSSSRVIEIEGKRYTVGALVLNNFGKREDLTIAGVPVGWELRDYPGRAKPSKGSIIMILATDAPLTARQLSRLAKRAVVGLARTGGYAYHGSGDIALAFSTAQRIKHYQRGEFEMKMLPDARLNRLFKAAAEATEEAIINSLLQAKTMTGRDNHIRYALPHDKLIEIMKKYRRLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ79</accession>
    <name>F0LJ79_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01626"/>
    <dbReference type="EnsemblBacteria" id="ADT84601">
        <property type="protein sequence ID" value="ADT84601"/>
        <property type="gene ID" value="TERMP_01626"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01626"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1626"/>
    <dbReference type="eggNOG" id="arCOG03887">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111879_0_0_2"/>
    <dbReference type="OMA" id="QYINATI"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024464">
        <property type="entry name" value="DUF2391"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09622">
        <property type="entry name" value="DUF2391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="166" mass="18974" checksum="09659B68ED9852ED" modified="2011-05-03" version="1">MTPEWLSKMSEELKQLNERFEKLSEQIEGLEKRFEKKPDKLGWDDIAQEIIGALTFSLPFLFTQEIWDIAKSLTMERAVGILILTLSIAYLFITKAKVSNIEREELFHIPKRLLTVVLISYLISAGLIYLYGINRLAEFSLNQYISATIIISTFAVIGAIAVDMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJC0</accession>
    <name>F0LJC0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467940.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01667"/>
    <dbReference type="EnsemblBacteria" id="ADT84642">
        <property type="protein sequence ID" value="ADT84642"/>
        <property type="gene ID" value="TERMP_01667"/>
    </dbReference>
    <dbReference type="GeneID" id="26137134"/>
    <dbReference type="KEGG" id="tba:TERMP_01667"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1666"/>
    <dbReference type="eggNOG" id="arCOG05869">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2257500_0_0_2"/>
    <dbReference type="OMA" id="FYEVWKY"/>
    <dbReference type="OrthoDB" id="106329at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043960">
        <property type="entry name" value="DUF5748"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19022">
        <property type="entry name" value="DUF5748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="102" mass="11958" checksum="6FD41736DE4DE3B6" modified="2011-05-03" version="1">MNLEVIKEFLEDIGADYTEIEGEIHLAPEVFYEVWKYVGQPDLKTYVIEDEIVEPGSYDPPEMKYTTAKKVKIKKVYFETLDNVKIVTDYAEFQRILKEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJE3</accession>
    <name>F0LJE3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hisC</name>
        <name evidence="5" type="ordered locus">TERMP_00432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466707.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00432"/>
    <dbReference type="EnsemblBacteria" id="ADT83409">
        <property type="protein sequence ID" value="ADT83409"/>
        <property type="gene ID" value="TERMP_00432"/>
    </dbReference>
    <dbReference type="GeneID" id="10040750"/>
    <dbReference type="KEGG" id="tba:TERMP_00432"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.432"/>
    <dbReference type="eggNOG" id="arCOG04273">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_2"/>
    <dbReference type="OMA" id="YPDMACT"/>
    <dbReference type="OrthoDB" id="69863at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="21"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="337" mass="38804" checksum="4FE432172509C2C2" modified="2011-05-03" version="1">MKIRGLVKSFEPYRVLEGNYKIWLDKNENPFDLPPEIKEEIFEELRKTPFNRYPHITAMPLREAIAEFYGLNPENVAVGNGGDELLSYLTRLFKGDYIVTTPPTFGMYYFYAKLNEIPVVEVPLDESFTINGDMIAEKAKKASIVFITSPNNPTGNTQPREEILKVLDTGVTVVLDEAYAEFSGKSCIDLLDKYENLIILRTFSKAFSLAGARAGYLLADEEIINAFYRIKSPFSLNSLTMITAKVMLNHYDVVMERVNYIIKERERIYKKFKDYAYPSEANFLLMRLDAYEFLLEKGIVVRKLGGQLKEHIRVTIGKREENDELINALKEFLEGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJJ2</accession>
    <name>F0LJJ2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiamine-monophosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466756.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00481"/>
    <dbReference type="EnsemblBacteria" id="ADT83458">
        <property type="protein sequence ID" value="ADT83458"/>
        <property type="gene ID" value="TERMP_00481"/>
    </dbReference>
    <dbReference type="GeneID" id="10040799"/>
    <dbReference type="KEGG" id="tba:TERMP_00481"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.481"/>
    <dbReference type="eggNOG" id="arCOG00636">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041631_0_0_2"/>
    <dbReference type="OMA" id="NDIAVRG"/>
    <dbReference type="OrthoDB" id="34102at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="48"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="152"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="330" mass="35395" checksum="46B9AF63557CDC61" modified="2011-05-03" version="1">MLPVGKVPPEKLRDVVFKHLGVRGERVLIKSGIGIDASAIDFGDSVLVASTDPITGAEKHIGFYAVNINANDVATFGAKPKWFLVSVLLPENADEKLLKEIMSDIDKSAKSLDIAVIGGHTEVTPGLKKPIVVGTMLGEVKKEKLVHAGNAKPGDAIILTKGAGIEGTAIIASEREDELVGVFGKEFVERAKAFLWKISVVKEALIANEIGVNAMHDPTEGGIANGLHEMADASGLGFEVHYERIPIAEETRKICEYFNLDPLSLISSGALLIAAPKENADEIVAALKKENLAASVIGEFLGDKKKRIIIRDGAEKELKQPLSDELWKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJL1</accession>
    <name>F0LJL1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467951.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01678"/>
    <dbReference type="EnsemblBacteria" id="ADT84653">
        <property type="protein sequence ID" value="ADT84653"/>
        <property type="gene ID" value="TERMP_01678"/>
    </dbReference>
    <dbReference type="GeneID" id="10041994"/>
    <dbReference type="KEGG" id="tba:TERMP_01678"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1677"/>
    <dbReference type="eggNOG" id="arCOG01369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="OMA" id="NLGNEDW"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="318" mass="35715" checksum="F897FA90341B2D70" modified="2011-05-03" version="1">MKVLVTGGAGFIGSHLVDRLMEQGYEVRVIDNLSAGSLNNIKQWLDHERFEFLKGDLRSKEVAKKAVKDVEVVFHLAANPEVRIGAQSPGLLYETNVLITYSLLEAIREEEVQYLVFTSSSTVYGDAKVIPTPEDYAPLEPISVYGGAKLAAEALISGYAHTFDIKSLVFRLANIIGERSNHGVIYDFINKLKADPNRLEILGDGTQKKSYLHVSDTVEGMLFLFEKFKEENKTYDVYNLGSEDWITVKEIAEIVSEEMGLSPEFYFTGGVDGGRGWKGDVKFMRLSIEKAKRKGWKPKMNSYGAVRRTVQELLRTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJM6</accession>
    <name>F0LJM6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alanyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467966.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01693"/>
    <dbReference type="EnsemblBacteria" id="ADT84668">
        <property type="protein sequence ID" value="ADT84668"/>
        <property type="gene ID" value="TERMP_01693"/>
    </dbReference>
    <dbReference type="GeneID" id="10042009"/>
    <dbReference type="KEGG" id="tba:TERMP_01693"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1692"/>
    <dbReference type="eggNOG" id="arCOG01254">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_7_2_2"/>
    <dbReference type="OMA" id="DREFKYD"/>
    <dbReference type="OrthoDB" id="40337at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="4">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="408" mass="46965" checksum="F33D0D17407D9785" modified="2011-05-03" version="1">MTAKLFYEDAYLNEAKAKIESLEIRGNKVRLNLDRTIFYPEGGGQPSDKGIIRGDGFEIRVEKVYGKDEIWHEGTLKGREPKPGEEVELELDWEWRYENMKQHTGQHILSAVLKDLYDSNTTGFQIFENYNKIEINFNGKLTWEHILNAEIRANEIVSKDLPVEIEFYNELPEDLRNQLRKDLSDKIKPPIRIVSIPGVDVIPCGGTHVKSTREVGFIKVVNFYKKSKNIWRIEFVCGNRALRYLDELLEDYWESLDEMPNKNRPLIKRVRELKNEIVKLEEEKKALRLELWEWKAKALLRGSEEVKGIKIVSTVEELDMKDAQAFVVYLVDKNPNTIALFVGRNYVIFAKNRGVEGVSMKELLREVIKETGGGGGGSEVLAKGGGFKVEPEKVLEIAKEKLKQLLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJQ8</accession>
    <name>F0LJQ8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84700">
        <property type="protein sequence ID" value="ADT84700"/>
        <property type="gene ID" value="TERMP_01725"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01725"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1724"/>
    <dbReference type="eggNOG" id="arCOG03886">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_204994_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="53" mass="6023" checksum="0A60FCB0943E47AE" modified="2011-05-03" version="1">MGVITVKIPDDLEVRFRKKILDVYGVKKGALGKAISEAIELWLEKHEKSGERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJT5</accession>
    <name>F0LJT5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468024.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01752"/>
    <dbReference type="EnsemblBacteria" id="ADT84727">
        <property type="protein sequence ID" value="ADT84727"/>
        <property type="gene ID" value="TERMP_01752"/>
    </dbReference>
    <dbReference type="GeneID" id="10042068"/>
    <dbReference type="KEGG" id="tba:TERMP_01752"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1751"/>
    <dbReference type="eggNOG" id="ENOG502N5NG">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2217180_0_0_2"/>
    <dbReference type="OMA" id="WALSYAY"/>
    <dbReference type="OrthoDB" id="124676at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="107" mass="11965" checksum="8DC2C9AB96D1C51D" modified="2011-05-03" version="1">MLAEFTVGFLFTLTWAGFFVIVGKQKSIWKATLGVTILFLAMIVLNYAKYRLGEPLGWFLGTIVGFLLSLWFVQRVGPEKPTKESAVAMFLFGPLIFAALLIVVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJU2</accession>
    <name>F0LJU2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation initiation factor 1A</fullName>
            <shortName evidence="3">aIF-1A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eif1a</name>
        <name evidence="8" type="ordered locus">TERMP_00502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3 6">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466777.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00502"/>
    <dbReference type="EnsemblBacteria" id="ADT83479">
        <property type="protein sequence ID" value="ADT83479"/>
        <property type="gene ID" value="TERMP_00502"/>
    </dbReference>
    <dbReference type="GeneID" id="10040820"/>
    <dbReference type="KEGG" id="tba:TERMP_00502"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.502"/>
    <dbReference type="eggNOG" id="arCOG01179">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109098_1_2_2"/>
    <dbReference type="OMA" id="ADITWRY"/>
    <dbReference type="OrthoDB" id="102432at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="PTHR21668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="7">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="114" mass="13259" checksum="6F1C55AA22866A0D" modified="2011-05-03" version="1">MARPRRDNRKVEGDEVIRVPLPEGNQLFGVVEQALGAGWMDVRCEDGKIRRCRIPGRLKRRMWIKVGDLVIVQPWPVQTDKRGDIVYRYTRTQVDWLIRKGKISQEFLTGGLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJX4</accession>
    <name>F0LJX4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466809.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00534"/>
    <dbReference type="EnsemblBacteria" id="ADT83511">
        <property type="protein sequence ID" value="ADT83511"/>
        <property type="gene ID" value="TERMP_00534"/>
    </dbReference>
    <dbReference type="GeneID" id="10040852"/>
    <dbReference type="KEGG" id="tba:TERMP_00534"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.535"/>
    <dbReference type="eggNOG" id="arCOG03647">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160445_2_0_2"/>
    <dbReference type="OMA" id="FDDIKWE"/>
    <dbReference type="OrthoDB" id="124033at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="98" mass="11633" checksum="C5A38B2C03FE3FCB" modified="2011-05-03" version="1">MEILKRVIKEFNKYHGSEAQAKIIKAERDEVIIEFDGSFCKTCGLYDYFEDIKWEAMNFGLNIEPVEIIESEEEFERGRYLVKYKLKSEQSSQQARQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJY3</accession>
    <name>F0LJY3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-threonine 3,O-phosphate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00543"/>
    <dbReference type="EnsemblBacteria" id="ADT83520">
        <property type="protein sequence ID" value="ADT83520"/>
        <property type="gene ID" value="TERMP_00543"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00543"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.544"/>
    <dbReference type="eggNOG" id="arCOG04273">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_2_2"/>
    <dbReference type="OMA" id="YPDINYT"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="26"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="325" mass="37544" checksum="E9D0424B3CCAF379" modified="2011-05-03" version="1">MMLKPVKFKTHHGGVREEGLLDFSASLNPYLPEWVDEMFERAKTLSKRYIYWEKLEEELSNLIGEKVTVTAGITEALYLLGILAMKERRKVIIPEHTYEEYERIARIFNAEVIKGPNNPEALAEFVAKSSIVFFCNPNNPDGKFYSPKRLKLLIQAVEDTDSLLVLDEAFIDFVKDARSPKGENILKLRTFTKSYGLPGIRVGYVIGFSEAFKSVRMPWSIGSLGYAFLEFVVRDEFKHLEKTMPLIWKEKERIEKALNVKSDANFFIKNVGNAKGAVEFFKKKGIAVRDCTSFGLPEYIRFSVRKREENEKLIDAFREFFQYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJZ7</accession>
    <name>F0LJZ7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vitamin B12 ABC transporter, B12-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466832.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00557"/>
    <dbReference type="EnsemblBacteria" id="ADT83534">
        <property type="protein sequence ID" value="ADT83534"/>
        <property type="gene ID" value="TERMP_00557"/>
    </dbReference>
    <dbReference type="GeneID" id="10040875"/>
    <dbReference type="KEGG" id="tba:TERMP_00557"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.558"/>
    <dbReference type="eggNOG" id="arCOG04233">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_437218_0_0_2"/>
    <dbReference type="OrthoDB" id="7675at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="87"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="358"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="619" mass="68375" checksum="16E237E989EF5B46" modified="2011-05-03" version="1">MKRKVALILTILMFGVIIAGCINQQTSSTPSTTPTSTTTQATSSKEMTVAHTTSTTKAPTETEQRKYPITITDFADRKVTIEKEPQRIVSLAPSITETLYFLGALDKVVGVTQYDDFPPGVQEGRTIIGGFSNPNIEIIASLKPDLIIATSMHMKYLTQLEQIAPVVIIDPKNMDDIYKAIELLGKVVDKEEQAQKVIANMKSKVEEIQSAVKSKPKVKVFYVVWNNPMMTAGKGTFIDDLIKLAGGENIFSDVEGWAQVSIEQVLAKDPEVIILTPHCGMTVQDVYHSELSKTTAAKEGKVVVIQNDNVLVRPSPRIVIGLEELAKVIHPDVFGGKYPLTVIDFMNRTVTIEKEPQRIVSLAPSITETLFYIGAGDKVVGVTKYDDFPPQVANITKIGGFSDPNIEIIASLKPDLIIGTSMHLKYLDQLQQIAPVIIVAPRNIDEIYKQIELLGKVTNREEYAQSVVNEMKAKVEYITSRVREKPKPKVFFISWWNPIYTPGRDTFQGDLIELAGGENVFNDLTGWAQVSIEQVLARNPEIIILSAHAGISPEQLCETELAKTDAVKNGRVYVISDDNIISRPGPRIVLGLEELAEFIHPEVFNYEPQPLKCSASVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK58</accession>
    <name>F0LK58_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468066.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01795"/>
    <dbReference type="EnsemblBacteria" id="ADT84770">
        <property type="protein sequence ID" value="ADT84770"/>
        <property type="gene ID" value="TERMP_01795"/>
    </dbReference>
    <dbReference type="GeneID" id="10042111"/>
    <dbReference type="KEGG" id="tba:TERMP_01795"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1794"/>
    <dbReference type="eggNOG" id="arCOG01521">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_668371_0_0_2"/>
    <dbReference type="OMA" id="ALHMIPH"/>
    <dbReference type="OrthoDB" id="20763at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="419" mass="46576" checksum="BD4A07FCE4518C54" modified="2011-05-03" version="1">MRVVTIGAGLGGLLTSAFLAKAGYEVIVLEKSSFIGGRFTNLRYKGFQLSTGALHMVPHGEDGPLAHLLKLLNANVKIVNSNPKGKFFIDGNLYHYREGWKYLSFKEKAKAMKLLAEIKANRLPKGEDAQMNAWEWLSDKIGENEFAYLFIKSFLGWAVSLAPEEVPAIEFAKEIKATLKWGGPGLIKGGCKAVTDELARIVRENGGEIITRKKVVEAEEGKVFTADGEEYPYDILISNIGIKETVELFGRENFDKEYLKKLDSLKPAEGIKINIALKGKPRIGNTVVFTLDTKRINGYNEPSALSPELAEEGYTLIMAHQALRSRNIKKEQRLGVEDLYYLFPELDKNGEILLIQTYLDGNPVNRVASGQHLDFPMENVYIVGDANKGEGGIEVEGIALGVMKVLQELGVGRFDEWYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK67</accession>
    <name>F0LK67_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (cytosine(72)-C(5))-methyltransferase</fullName>
            <shortName evidence="4">tRNA:m(5)C72 MTase</shortName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>cytidine(72) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:61988"/>
            <dbReference type="Rhea" id="RHEA-COMP:15996"/>
            <dbReference type="Rhea" id="RHEA-COMP:15997"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468075.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01804"/>
    <dbReference type="EnsemblBacteria" id="ADT84779">
        <property type="protein sequence ID" value="ADT84779"/>
        <property type="gene ID" value="TERMP_01804"/>
    </dbReference>
    <dbReference type="GeneID" id="10042120"/>
    <dbReference type="KEGG" id="tba:TERMP_01804"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1803"/>
    <dbReference type="eggNOG" id="arCOG00973">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00986">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_1_0_2"/>
    <dbReference type="OMA" id="YQGAMLY"/>
    <dbReference type="OrthoDB" id="32049at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02237">
        <property type="entry name" value="NSUN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043699">
        <property type="entry name" value="NSUN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="6">
        <location>
            <begin position="101"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4 5">
        <location>
            <begin position="205"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="384" mass="43758" checksum="33174FC44A88A585" modified="2011-05-03" version="1">MYLEAFPEELQEYYRKLFGEEAEIIMQKLREPVEKYYIRVNTLKISRDKLIDELKREGLKPKRSPYLDEGIYFDREGPNFPDDYNPRLPTVVANKYAAESVYQGAMLYAPGVLKADKSIKEGDEVQIRDPKGLLVGIGTAKMNAKEMIKATRGIAVEVTLPKFKLPSLSELKSFEKGYFYPQSLPSMVTARILEPNEGDLIIDMAAAPGGKTTHLAQLMQNRGEIIAIDKSKNRLRKMEETLKRLGVKNVKLVHMDSRNLPELGIKADKILLDAPCTALGVRPKLWESRTPKDIIATARYQRHFINAAIKSLRKGGILVYSTCTLSYEENEGNVKYMIKKGLRLEKQSFFIGSPGIGLKEVQRFYPHKHLTQGFFIAKLRKVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK77</accession>
    <name>F0LK77_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Putative toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ordered locus">TERMP_01814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468085.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01814"/>
    <dbReference type="EnsemblBacteria" id="ADT84789">
        <property type="protein sequence ID" value="ADT84789"/>
        <property type="gene ID" value="TERMP_01814"/>
    </dbReference>
    <dbReference type="GeneID" id="10042130"/>
    <dbReference type="KEGG" id="tba:TERMP_01814"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1813"/>
    <dbReference type="eggNOG" id="arCOG02219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_3_2_2"/>
    <dbReference type="OMA" id="PYDLQIA"/>
    <dbReference type="OrthoDB" id="104470at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="142" mass="16239" checksum="06C66DCD0ED1F169" modified="2011-05-03" version="1">MENLILDTDVVIDFLRGKRETIEKLKELRKTYQFIITTITAFELYLGAYKSQKREKRLLEVKAFLNTLLILELDEVSAEIAGKIAAELSKDGEPIDVRDLLIGSIAISHSIPLLTNNVKHFERLKKFGLKLLGIENANRKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK98</accession>
    <name>F0LK98_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OrfB_IS605 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00579"/>
    <dbReference type="EnsemblBacteria" id="ADT83556">
        <property type="protein sequence ID" value="ADT83556"/>
        <property type="gene ID" value="TERMP_00579"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00579"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.580"/>
    <dbReference type="eggNOG" id="arCOG00683">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040997_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="1">
        <location>
            <begin position="179"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="281" mass="32550" checksum="F288F3AE4FE07156" modified="2011-05-03" version="1">MKRSVTVKLQPSKAQEKILFELAQATAIIWNKLNYLRLKQFKEFGKIDFNGTEKEAYYCFKDWIGGSTVQQLARKNAEAWRSFFSLNRKKKKGELPEWFKPKPPKFVKEKNGKKLFVIPLRNDQYQIDGNVIELRRLGKFGKLKIQFKGRIHLKGKQGRLEIAYDDVRRKWYAHISFTVEEKLESGEWVSVPRKPRGNLSAGIDLGVNNLMAVYVENGESFLVNGRPLKSIDFYWRRKIAEYQSKLNKSGAKTSRKLKAEPEGLIFGFNEAPQTSPPMARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKE1</accession>
    <name>F0LKE1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron (Iii) abc transporter atp-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466897.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00622"/>
    <dbReference type="EnsemblBacteria" id="ADT83599">
        <property type="protein sequence ID" value="ADT83599"/>
        <property type="gene ID" value="TERMP_00622"/>
    </dbReference>
    <dbReference type="GeneID" id="10040940"/>
    <dbReference type="KEGG" id="tba:TERMP_00622"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.624"/>
    <dbReference type="eggNOG" id="arCOG00198">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_2"/>
    <dbReference type="OMA" id="FHIDAEI"/>
    <dbReference type="OrthoDB" id="68573at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="238" mass="26881" checksum="FE3FEFDEA6D44656" modified="2011-05-03" version="1">MLEVNISFSYGSRRILHDVEFSAQKNSLLAIIGPNGAGKSTLLKCMVGILKPEGYVNFNNINLIELKPKERAKFITYVPQTSVPEFAFTIEEFVEMGTYATRGDIKEALRKVGMWERRKEFVTNLSGGEYQLVLIARALAQGSEVILLDEPTSHLDINHALLVMNLLKDIKEEKIVIAVMHDLNLALQYSDEIILLNKGKVEWKGNTKDLKPEVLERVYSVKAKILKVENKPIVLVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKH2</accession>
    <name>F0LKH2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466928.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00653"/>
    <dbReference type="EnsemblBacteria" id="ADT83630">
        <property type="protein sequence ID" value="ADT83630"/>
        <property type="gene ID" value="TERMP_00653"/>
    </dbReference>
    <dbReference type="GeneID" id="10040971"/>
    <dbReference type="KEGG" id="tba:TERMP_00653"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.655"/>
    <dbReference type="HOGENOM" id="CLU_2550451_0_0_2"/>
    <dbReference type="OrthoDB" id="142618at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="82" mass="9018" checksum="00292F0A45CE4A30" modified="2011-05-03" version="1">MATAYKLAVLPIVGSILARIMGPTSPKTAAYLFVIFLVLYPGWFIYKTSIAGFYEEEKGQMIKAFVLWFACFVGGVVILFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKK2</accession>
    <name>F0LKK2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bipolar DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468132.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT84836">
        <property type="protein sequence ID" value="ADT84836"/>
        <property type="gene ID" value="TERMP_01861"/>
    </dbReference>
    <dbReference type="GeneID" id="10042177"/>
    <dbReference type="KEGG" id="tba:TERMP_01861"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1860"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="33242at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018538">
        <property type="entry name" value="HerA_barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09378">
        <property type="entry name" value="HAS-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAS-barrel" evidence="3">
        <location>
            <begin position="14"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="DUF87" evidence="2">
        <location>
            <begin position="144"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="532" mass="60156" checksum="A707D77C0CD54C97" modified="2011-05-03" version="1">MPEITEELGSFEKIGVVTGESTHVEFYFAVEDEKMPQVWDYVVVPSNELIDGEEKRVLVLGQITSIIAYSPGLTEYVPYSVAEKLKEAEIIEPRNLAKVKILGFLHNGTVLMPRRTIYPGTYVYLAPDDILTEVYSYPEEEGLYIGNLITRPSVKVNLTIRGFRRHLAILAQTGAGKSYTAGVLLEELYKKGATVIVLDPHADYVFISKDPEGKKKVLKRVRVFRTLESTGRYTKEEIGHVETFEIKFADLSLEEIFTIAGINENWTNIMKAIEDALERLKNSSKNYTLDDLITALQTSDNNNALRALTYIKRLKKLKVFGDSTTPIGEFLQPQSIAVMDLSGLNDNVADYIAYKILSEAYNQRESGKYEYPIFILIEEAHRFIPKNQNTLSKRIVKKIAAEGRKFGVFLILVTQRPQKIDSDVLSQCNSQIIMRMTNPEDQKAVRMSAEQVSEDLLRDLPGLNVGEAIIVGEVTKMPVMVKIRKRMTKEGGADIDIVAKLREAMKAAEEYEKNLDNVIREELEKIKSIVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKM6</accession>
    <name>F0LKM6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468156.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01885"/>
    <dbReference type="EnsemblBacteria" id="ADT84860">
        <property type="protein sequence ID" value="ADT84860"/>
        <property type="gene ID" value="TERMP_01885"/>
    </dbReference>
    <dbReference type="GeneID" id="26137408"/>
    <dbReference type="KEGG" id="tba:TERMP_01885"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1884"/>
    <dbReference type="eggNOG" id="arCOG04140">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179754_1_0_2"/>
    <dbReference type="OMA" id="VVHSIDM"/>
    <dbReference type="OrthoDB" id="126791at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003831">
        <property type="entry name" value="DUF211"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023129">
        <property type="entry name" value="MTH889-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42240">
        <property type="entry name" value="PTHR42240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02680">
        <property type="entry name" value="DUF211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160363">
        <property type="entry name" value="SSF160363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="101" mass="11243" checksum="57A2BF8EFB500352" modified="2011-05-03" version="1">MARGIRLLVLDVLKPHQPMVTELALGLSEIRGVEGVNITLVEIDKETENIKITIVGDNLDYDEIVRTIEEFGGVVHSIDMVAAGKRIIEESETPQDKLDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKQ0</accession>
    <name>F0LKQ0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468180.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01909"/>
    <dbReference type="EnsemblBacteria" id="ADT84884">
        <property type="protein sequence ID" value="ADT84884"/>
        <property type="gene ID" value="TERMP_01909"/>
    </dbReference>
    <dbReference type="GeneID" id="26137445"/>
    <dbReference type="KEGG" id="tba:TERMP_01909"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1908"/>
    <dbReference type="eggNOG" id="arCOG05834">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151096_0_0_2"/>
    <dbReference type="OMA" id="FPTYLLM"/>
    <dbReference type="OrthoDB" id="112148at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="139" mass="15711" checksum="3CD13E5719038BF6" modified="2011-05-03" version="1">MKKPRIKFSPIPLIILAFLLLSYPKILPILILALPAFLSYFLGVFFLVVFIIFLLYYKIGGMFGVLLVALALLFVESAYLDREKAPREHYLILTVSVLLALPTYLFIRTLAVAMPRLEVTAVAMLILLVLYAFSKVVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKT7</accession>
    <name>F0LKT7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Deblocking aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_00689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466964.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00689"/>
    <dbReference type="MEROPS" id="M42.009"/>
    <dbReference type="EnsemblBacteria" id="ADT83666">
        <property type="protein sequence ID" value="ADT83666"/>
        <property type="gene ID" value="TERMP_00689"/>
    </dbReference>
    <dbReference type="GeneID" id="26136091"/>
    <dbReference type="KEGG" id="tba:TERMP_00689"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.690"/>
    <dbReference type="eggNOG" id="arCOG01518">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_1_0_2"/>
    <dbReference type="OMA" id="YTLDNKA"/>
    <dbReference type="OrthoDB" id="27966at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="345" mass="37942" checksum="E738D0DFDBDDEC2B" modified="2011-05-03" version="1">MVDFELLRKVVEAPGVSGYEFLGIRDVVVEALKDYVDEIKIDKLGNVIAHKKGSGPKIMIAAHMDKIGLMVNHIDKNGYLHVVPVGGVDPRTLVAQRVRIFTENGELYGVVGHIPPHLTKPEERKKAADWDTIVVDVGADSKEEAEKMGIKVGTVMEFAPAFTKLTENRFASPYLDDRICLYAMIEAARAVENHEADIYFVASVQEEVGLRGARVASYAIDPEIGIAMDVTFAKQPGDKGKIVVELGKGPVMDVGPNINPKVRAFAEEVAKKYEIPLQVEPSPRPTGTDANIMQINREGVATAVLSIPIKYMHSQVELADVRDVDNTINLAKHFLEELKPMNLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKW9</accession>
    <name>F0LKW9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466996.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83698">
        <property type="protein sequence ID" value="ADT83698"/>
        <property type="gene ID" value="TERMP_00721"/>
    </dbReference>
    <dbReference type="GeneID" id="10041039"/>
    <dbReference type="KEGG" id="tba:TERMP_00721"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.723"/>
    <dbReference type="eggNOG" id="arCOG10651">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2766294_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="69" mass="8303" checksum="20A0C7E8804C488B" modified="2011-05-03" version="1">MGTTPLRKESDPIKELIPWARDDAIVQAFEERERERKEILEMIRNFRDISFLPEDAREIFGNIEKRDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKX5</accession>
    <name>F0LKX5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467002.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00727"/>
    <dbReference type="EnsemblBacteria" id="ADT83704">
        <property type="protein sequence ID" value="ADT83704"/>
        <property type="gene ID" value="TERMP_00727"/>
    </dbReference>
    <dbReference type="GeneID" id="10041045"/>
    <dbReference type="KEGG" id="tba:TERMP_00727"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.729"/>
    <dbReference type="eggNOG" id="arCOG01755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_2"/>
    <dbReference type="OMA" id="KVISCHS"/>
    <dbReference type="OrthoDB" id="36410at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="9"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="106"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="333" mass="37638" checksum="91867E6DA94813F6" modified="2011-05-03" version="1">MKPKVAVLFKMKSKPLEELKKYCDADVLLYPKKEDLMEVIHQYDGIIISPLNKIDAEIIEKAERLKVISCHSAGYDHVDINAATKKGIYVTKVSGVLSEVVAEFAIGLMIALLRKIAYSDKFIRQGKWESPKLVWSSFKNIESVYGKRVGILGMGAIGKAIARRAKALGTEILYWSRSRKEDIEKEVNAKYLPFEEVLKQSDIVVLALPATKETYHIINERTLKLMEGKYLVNIGRGVLVDEKAVIKALKEGKLKGYATDVFENEPVQESELFEIEWETVLTPHYAGLSKEAMLDMGIQAVKNLLKVFKGEIPEDLVNRDVLKIRPIESIKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKX7</accession>
    <name>F0LKX7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467004.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00729"/>
    <dbReference type="EnsemblBacteria" id="ADT83706">
        <property type="protein sequence ID" value="ADT83706"/>
        <property type="gene ID" value="TERMP_00729"/>
    </dbReference>
    <dbReference type="GeneID" id="10041047"/>
    <dbReference type="KEGG" id="tba:TERMP_00729"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.731"/>
    <dbReference type="eggNOG" id="arCOG02050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_5_4_2"/>
    <dbReference type="OMA" id="MYHHIIN"/>
    <dbReference type="OrthoDB" id="64126at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="254" mass="26713" checksum="59BCCE06A48F8E32" modified="2011-05-03" version="1">MLRYISYFAVGVVIGILAALFGLGGGFLIVPTLNLLGVEIHHAVGTSSAAVVFTSLSSALAYSRQKRVHYKVGLLLASTAIIGAYIGAWMTSLLNPAQLKVIFGATLILVAIRIYRKKTAEPSEVKLEDVKINYKLVPVGGFFAGIASGLLGVGGGIINVPFLVWLGMPIHYAVATSSFAIVFTAASGAIKHYMMGNVEAQWLVLLVPGLIIGAQLGAKIAKRTKASNLKRAFAVVLALLALRMILKGLGIAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKZ3</accession>
    <name>F0LKZ3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdenum cofactor carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468196.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01925"/>
    <dbReference type="EnsemblBacteria" id="ADT84900">
        <property type="protein sequence ID" value="ADT84900"/>
        <property type="gene ID" value="TERMP_01925"/>
    </dbReference>
    <dbReference type="GeneID" id="10042241"/>
    <dbReference type="KEGG" id="tba:TERMP_01925"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1924"/>
    <dbReference type="eggNOG" id="arCOG02431">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107614_0_1_2"/>
    <dbReference type="OMA" id="FMAYAMG"/>
    <dbReference type="OrthoDB" id="88478at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005268">
        <property type="entry name" value="CHP00725"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00725">
        <property type="entry name" value="TIGR00725"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="177" mass="19339" checksum="00B2614DFA75AC32" modified="2011-05-03" version="1">MIQIAIAGSSDEKPLEKAEKKAREFARELGKYKDEVVLLTGGRGGIMKIVSEEFTKAGGVVIGILPERQEGNEFNTIRIKTGMDFAERSAIMINSADVLVVLGGGIGTMVEALMAYDYGIPLIVVTDTGYASDRLELLARDGYFDHKRIVKVEFTSDPRDAVKLALELKKAEKSAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL25</accession>
    <name>F0LL25_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01958"/>
    <dbReference type="EnsemblBacteria" id="ADT84932">
        <property type="protein sequence ID" value="ADT84932"/>
        <property type="gene ID" value="TERMP_01958"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01958"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1956"/>
    <dbReference type="HOGENOM" id="CLU_078141_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="233" mass="26782" checksum="971F565F2758C4B1" modified="2011-05-03" version="1">MFKSIFENSRLIGGEILELKDSKGGSIASFNSTIPTEYKTLKEIERLNGSKGKIVIKIAEIFDKNSSYPEWKTYKRKCFYLIRTHKKDENKVKVSIVDGAFFETIPEKDLISTMFQNIFNKHAKEYPIPDKVKENASQVFQYLTDHSLISFSQDIPKASIKPRLRIMAEAKNEGNPHWEKYNIPPKTLNLIIKADNGSKTVGNIIEESELPIEIFTIAHQNDGEFLVFSYKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL54</accession>
    <name>F0LL54_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01987"/>
    <dbReference type="EnsemblBacteria" id="ADT84961">
        <property type="protein sequence ID" value="ADT84961"/>
        <property type="gene ID" value="TERMP_01987"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01987"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1984"/>
    <dbReference type="eggNOG" id="arCOG04474">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075238_0_0_2"/>
    <dbReference type="OMA" id="IHYETDG"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035185">
        <property type="entry name" value="DUF5305"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17231">
        <property type="entry name" value="DUF5305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="343" mass="39246" checksum="0EC9A7A73338AAF0" modified="2011-05-03" version="1">MEVSKVKRIDLKNIKRINKKKVGFAIAIAVFLLFSAYSAVALQKDPETITSQKMGSYMQRGVFQHKAFFSNTSLYGDVKSMKYYPKDITESISGVYVYTFTPGDDVTGRYKLTIVTTYYISKGKEKIVLWEEKLVERERELENGMMGEAITFNMNDMNRRMEIVKEGLGIKRISRETKIVVQVLAKGKVNGKYIKEEFDQTINMVIDSGNGLIYFTNDEVEAKKNIIDKNIQVNYVSFLGKPITVAAARKVFPLLALLSALPIFGMVYTAKAKTPKDELKDLRRYMIEGIPNKVDKKITLATEEDLKRTFELIDKPIMHYQEGNSDVYAIVDTGVVYEYRRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL75</accession>
    <name>F0LL75_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="6">PTH</shortName>
            <ecNumber evidence="6">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pth</name>
        <name evidence="7" type="ordered locus">TERMP_00749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467024.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00749"/>
    <dbReference type="EnsemblBacteria" id="ADT83726">
        <property type="protein sequence ID" value="ADT83726"/>
        <property type="gene ID" value="TERMP_00749"/>
    </dbReference>
    <dbReference type="GeneID" id="10041067"/>
    <dbReference type="KEGG" id="tba:TERMP_00749"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.751"/>
    <dbReference type="eggNOG" id="arCOG04228">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073661_2_2_2"/>
    <dbReference type="OMA" id="GHAAVEC"/>
    <dbReference type="OrthoDB" id="115947at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00628">
        <property type="entry name" value="Pept_tRNA_hydro_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034759">
        <property type="entry name" value="Pept_tRNA_hydro_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PTHR12649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="118" mass="13097" checksum="FF1026873A429A2C" modified="2011-05-03" version="1">MFKYKQVMVIRQDLKLSKGKLAVQVAHGAVTAAFQAYKEKPEWFKAWFHEGQKKVVVKVQNEKELFELKAEAEKLGIPTALIKDAGLTEIPPGTITCLAIGPAPEDLVDKVTGHLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLA8</accession>
    <name>F0LLA8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00782"/>
    <dbReference type="EnsemblBacteria" id="ADT83759">
        <property type="protein sequence ID" value="ADT83759"/>
        <property type="gene ID" value="TERMP_00782"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00782"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.784"/>
    <dbReference type="eggNOG" id="arCOG03957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051317_0_1_2"/>
    <dbReference type="OMA" id="QAHMDAI"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01048">
        <property type="entry name" value="Ferritin_like_AB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019243">
        <property type="entry name" value="DUF2202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09968">
        <property type="entry name" value="DUF2202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2202" evidence="3">
        <location>
            <begin position="63"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="243" mass="27679" checksum="12310235B8BD0118" modified="2011-05-03" version="1">MEEVKNMRKKILSLGLLGLMFGIIFGSVAAMPWWADTWDRGSNTTWDRPYVAIYGNDTLTQEEIDGLLWMREEEKLARDVYLTLYEMYGLQIFQNIASSEQMHMDAVLSLLEKYGIEDPAVDEVGVFTNPELQALYDQLIAMGSQSVEDALKVGALIEETDIKDLEEWIAKTDNADIIQVYENLMAGSENHLRAFTSVLQNYGITYEPQVISEDEYNEIISSPMNTGMDDKGRSMRGFRGGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLB1</accession>
    <name>F0LLB1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4405 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467060.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00785"/>
    <dbReference type="EnsemblBacteria" id="ADT83762">
        <property type="protein sequence ID" value="ADT83762"/>
        <property type="gene ID" value="TERMP_00785"/>
    </dbReference>
    <dbReference type="GeneID" id="10041103"/>
    <dbReference type="KEGG" id="tba:TERMP_00785"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.787"/>
    <dbReference type="eggNOG" id="arCOG04002">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1302686_0_0_2"/>
    <dbReference type="OMA" id="YLGFVMI"/>
    <dbReference type="OrthoDB" id="86382at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025517">
        <property type="entry name" value="DUF4405"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14358">
        <property type="entry name" value="DUF4405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4405" evidence="2">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="214" mass="23172" checksum="B772BDF54F47F748" modified="2011-05-03" version="1">MKAPAWLRGAVDLVLTVVFILIAVSGIALYQAPSGRIADAIGWTFLGVTKDTWETVHTYLGFVMIGLVAVHLIIGFNSMVVMLKSAFKKSRVKVAGSLILISLVLVGGYFAFAALTAEEETTSETTSSEGISVTVDNTTIEITGSMLKSLTLEQLAEMYDVDPQKLVEILKADYNIEAQPDQLLEMVEVNNELDREQFKEILAEAIAKAKQGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLE5</accession>
    <name>F0LLE5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Digeranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="9">DGGGP synthase</shortName>
            <shortName evidence="9">DGGGPS</shortName>
            <ecNumber evidence="9">2.5.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Geranylgeranylglycerol-phosphate geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_02000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18109"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="EC" id="2.5.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.42" evidence="9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468270.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02000"/>
    <dbReference type="EnsemblBacteria" id="ADT84974">
        <property type="protein sequence ID" value="ADT84974"/>
        <property type="gene ID" value="TERMP_02000"/>
    </dbReference>
    <dbReference type="GeneID" id="10042315"/>
    <dbReference type="KEGG" id="tba:TERMP_02000"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1997"/>
    <dbReference type="eggNOG" id="arCOG00476">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073311_1_1_2"/>
    <dbReference type="OMA" id="DYFDYEI"/>
    <dbReference type="OrthoDB" id="104789at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047295">
        <property type="term" value="F:geranylgeranylglycerol-phosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01286">
        <property type="entry name" value="DGGGP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023547">
        <property type="entry name" value="DGGGP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT84974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="281" mass="30241" checksum="B1E004847AD2161B" modified="2011-05-03" version="1">MEVKAFIEILRPHNCFVAGLVGILGSIVALGHFPKIKTAVLIFAVVFLGCSAGNTINDYFDYEIDKINRPTRPLPRGAMSRKTAFWYAMLLFVVGLVLAYRLNIYAFILAVAAYSVLLIYAWKLKPLPIIGNIMVASLTGATPLYGAIAVGKIGLAGYLALCAFLVNLAREIMKDIEDIEGDKAKGAKTLPIVWGIKKSAYLASLFGIATVVASFLPLKVGIGIGYLPMIVVDGLILAAVFELLKNPMPKTAGKAQKKLKAAIYLAVFSFLLGSITTGVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLF0</accession>
    <name>F0LLF0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">engB</name>
        <name evidence="9" type="ordered locus">TERMP_02005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468275.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02005"/>
    <dbReference type="EnsemblBacteria" id="ADT84979">
        <property type="protein sequence ID" value="ADT84979"/>
        <property type="gene ID" value="TERMP_02005"/>
    </dbReference>
    <dbReference type="GeneID" id="10042320"/>
    <dbReference type="KEGG" id="tba:TERMP_02005"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2002"/>
    <dbReference type="eggNOG" id="arCOG00355">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033732_3_0_2"/>
    <dbReference type="OMA" id="PNHYDWA"/>
    <dbReference type="OrthoDB" id="73254at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="8">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="190" mass="22034" checksum="CE2C2E86D2D1CDC7" modified="2011-05-03" version="1">MIIFVGRSNVGKSTLIYRLTGKKVKRGKKPGVTRKPIEIIWRNKRVIDMPGFGFMSGIPKHVQERIKTDIVRFIEEHAGEIEVAVLVIDGKSALEIIERWERRGEIPIDVEFFQFLQELNIPTVVAVNKLDKIKNVSLTINKLIEKFGLSGTWEDYKELFVPVSAKFGTNIEELRKVIDKKIREFQERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLI3</accession>
    <name>F0LLI3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3">N5-CAIR mutase</shortName>
            <ecNumber evidence="3">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purE</name>
        <name evidence="6" type="ordered locus">TERMP_02038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02038"/>
    <dbReference type="EnsemblBacteria" id="ADT85012">
        <property type="protein sequence ID" value="ADT85012"/>
        <property type="gene ID" value="TERMP_02038"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02038"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2035"/>
    <dbReference type="eggNOG" id="arCOG02464">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094982_2_2_2"/>
    <dbReference type="OMA" id="SNSIDGW"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="5">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT85012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="141" mass="15046" checksum="AE7E380AF2930F4B" modified="2011-05-03" version="1">MLVVMGSKSDSHIAEKVTKVLDEFGIEYDVEVASAHRNPKKVEELAKKDYDVFIAIAGLSAALPGVIASYTTKTVIGVPVSAKLGGLDALLSIAQMPPGVPVAAVGIDNGKNAALLAIQILALKDESLRKKLEEYRERMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLK0</accession>
    <name>F0LLK0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468325.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02055"/>
    <dbReference type="EnsemblBacteria" id="ADT85029">
        <property type="protein sequence ID" value="ADT85029"/>
        <property type="gene ID" value="TERMP_02055"/>
    </dbReference>
    <dbReference type="GeneID" id="10042370"/>
    <dbReference type="KEGG" id="tba:TERMP_02055"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2052"/>
    <dbReference type="eggNOG" id="arCOG03169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053804_1_1_2"/>
    <dbReference type="OMA" id="HPQDTML"/>
    <dbReference type="OrthoDB" id="35313at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="368" mass="43415" checksum="7D20DAB15DB5547E" modified="2011-05-03" version="1">MENPFIFGEPAKGEKFIDRKRELERLRNYIINARNVIIYSPRRFGKTSLILKVLEELKGDIIPIFIDCYSVTSEKDLASRLTKKVLQHYKGKEIWYAVKKLFQNITPKITIETTPSVQIEISYEGVENWEEALDLPQKLALDKGKRVVVVFDEFQELAKFDNLLKLLRSRFQHHDKVSYIFIGSKRHLMEWIFKSKESPFYNFGAHITLKEIPKKEFEIYIQDAFKRGNIKIKEHVVDLILSLTRCHPYYTQRLCFELWYVGTLKKVVDEKDVEKTLSELISDLEDSYLLIWESLTPNQRKALLAVAKGEEDLFSGEFLRKYDFKSPASVQSALRKLVEKELVTKIGEAYKVSDVFMEYWLKKRFLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLL3</accession>
    <name>F0LLL3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0128 protein TERMP_00813</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0128 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467088.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00813"/>
    <dbReference type="EnsemblBacteria" id="ADT83790">
        <property type="protein sequence ID" value="ADT83790"/>
        <property type="gene ID" value="TERMP_00813"/>
    </dbReference>
    <dbReference type="GeneID" id="26136265"/>
    <dbReference type="KEGG" id="tba:TERMP_00813"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.815"/>
    <dbReference type="eggNOG" id="arCOG05084">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1243079_0_0_2"/>
    <dbReference type="OMA" id="FGRFVFQ"/>
    <dbReference type="OrthoDB" id="58756at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00264">
        <property type="entry name" value="UPF0128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005266">
        <property type="entry name" value="UPF0128"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03673">
        <property type="entry name" value="UPF0128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016179">
        <property type="entry name" value="UCP016179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00703">
        <property type="entry name" value="TIGR00703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="222" mass="26414" checksum="4BA5F83CD1FC74E3" modified="2011-05-03" version="1">MLEGYYIIENSGVVPAERRFKFKDLKAWGYDLHLGTIEGKRAYFVSGAGEKREGESYTVKGKEYRITETQQEIPPNARLLAKIVIERGQPYLVFWLEEEEQTFPLAKEDPRIILKRFWDTKKFKQLLKHVNSVGLTTDFYKDNVFTKSVPLPYEEYPPKVRRVLREVRDIHRDLTGFGRFVFQYYGEEDKMHNYRLWWLLPTIYLFDVEIANEVDKILGMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLN3</accession>
    <name>F0LLN3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467108.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00833"/>
    <dbReference type="EnsemblBacteria" id="ADT83810">
        <property type="protein sequence ID" value="ADT83810"/>
        <property type="gene ID" value="TERMP_00833"/>
    </dbReference>
    <dbReference type="GeneID" id="10041151"/>
    <dbReference type="KEGG" id="tba:TERMP_00833"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.836"/>
    <dbReference type="eggNOG" id="arCOG02406">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102061_0_0_2"/>
    <dbReference type="OMA" id="INPCTFV"/>
    <dbReference type="OrthoDB" id="75096at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="241" mass="27000" checksum="563DA86E06AA7E33" modified="2011-05-03" version="1">MKDEIKTLLLIISLSFGLTILVLFLVNLQSMIFPLISLAVSDSINPCTFVIYTMFLIALSLKEGISKRKIYEIGMAFVVAIYISYYILGIGLVVFTRSIPTWIAGVVSLIFGFYTFFTGYFEKSRVAGKKNVRKSIFRQEATLFGAFALGVMVSFTLLPCSAGSYLIYAILISKIGRTLTWILLGLYNLIFVLPLLIILFTVSSIAESKSLSQKIVRRSRELSMIAGFVLMLLGVYVLFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLQ9</accession>
    <name>F0LLQ9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH adaptation potassium efflux system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467134.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00859"/>
    <dbReference type="EnsemblBacteria" id="ADT83836">
        <property type="protein sequence ID" value="ADT83836"/>
        <property type="gene ID" value="TERMP_00859"/>
    </dbReference>
    <dbReference type="GeneID" id="10041177"/>
    <dbReference type="KEGG" id="tba:TERMP_00859"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.862"/>
    <dbReference type="eggNOG" id="arCOG01537">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_5_2"/>
    <dbReference type="OMA" id="NAWAPDA"/>
    <dbReference type="OrthoDB" id="28394at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="2">
        <location>
            <begin position="129"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="496" mass="53439" checksum="1BC71DC67C03A832" modified="2011-05-03" version="1">MMQYASLLIALPLFSAFLVPLIKRAGKKVILYYLSLVTLIQTGIAAWVFKEVYTTGKPIIVIAGGFKPPVGINLYIGHFAALFILIIAIVSFFMTVFSIKAIAVEPIDKYAMLFLLLMLGSTGMIATGDIFNLFVFMEITAISAYALTGYNKTGEASEAAMKYIVLGGIGSSFFLVGIALLYGSLGTLNLAQIAMLASKINPTVAQAALALLVFGLAVEAELFPLNAWAPDAYQASPHPVTVMFSAFVVKAGIYAMIRIVYLFKDTQAFMGILSLLLILGTLTVIVGELSALRQTNVKRMLAYSSIAQIGLIAVGFGVATPQAIDAAVFHMLNHAIVKTLMFLAVGYVAVKFGSPQIENFRGLGKRMPLTAFAITVGAISIVGIPLFNIFWSKFKLLLAALQVGKTGIVALILGASLVEAVYYFRLLHLMWFEEGKGEKVEEDLALGVIMLLLVALIVVIGVYPDFVWGIVQKASADLYDVAQYVKNVPLLQGVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLV3</accession>
    <name>F0LLV3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-phosphooligosaccharide-protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Oligosaccharyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">TERMP_02078</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.21" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468348.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02078"/>
    <dbReference type="EnsemblBacteria" id="ADT85052">
        <property type="protein sequence ID" value="ADT85052"/>
        <property type="gene ID" value="TERMP_02078"/>
    </dbReference>
    <dbReference type="GeneID" id="10042393"/>
    <dbReference type="KEGG" id="tba:TERMP_02078"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2075"/>
    <dbReference type="eggNOG" id="arCOG02044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355503_0_0_2"/>
    <dbReference type="OMA" id="FWYSVAL"/>
    <dbReference type="OrthoDB" id="5183at2157"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="PTHR13872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ADT85052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="768" mass="87394" checksum="0AC58DC4B1CFB720" modified="2011-05-03" version="1">MKKLDKVFEPKVALPLVTLIAAVFRLIPLRYKYLFGYDPYFHLAYIEESLKAGYWLNFLTIAGGPWGVQVKNFHPLGLWMVPADVYKILKIFGVSLYDAFRITPVIFGVLTIIFFYLAMLNFYGKREAFFSALFLSVMFGHVFRSMANYYRGDNYMLFWYSVALFGVSLALKKTRRAWRYKRFAFYLIPAFASGLAAIFWQAYYPIFIFLLGNAVLLAFGAFILEKDKYLVDSAVLTLSTAFGAFLANYLGEYFGYGMLGGNRWLAKKTAEKLGIELGAIKDVYLAVHLKYLVPLALAGIFALFLLSRIVNEKKQRALIVLILSILGVFVLFMRFDALKELSSGFGIFREAPILETQPSTFSDLWAAYNILVFLCPLFVLRFVPKKVKLSDFVLLGVIAPSLYMLYTWTRFLFIGSFAVAAMAGVGLICLHDFLKPKLESKKALALSVSLLVVVPIISAGLGFERVYAERPIINDRWVQALTWLKDNSNENDVVLAWWDYGHWVTYYARRSPIVQGGPSRWVALYYLGKVNNNQLMARGVDYVIVSYDTALKFGAILDTANISREGYFLMILPLVSKVGALIFQQGQYTITARPGKEWSILINTGTAVFSPKEAFVEYKNSITRLNITAKNTADAYVYLNLNYGYAVLMSEKTFNTTLARLMFTDEYSKDYQLVYSDGGYIKIFKFKHPNVAVEQTEKEIIFKFENATGTGLGVFGYLENGTLVFKRWYPVKGKNEFILPKDQVNGTVIRYAYAEGKKIVDRGVFRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLV4</accession>
    <name>F0LLV4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate thymidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468349.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02079"/>
    <dbReference type="EnsemblBacteria" id="ADT85053">
        <property type="protein sequence ID" value="ADT85053"/>
        <property type="gene ID" value="TERMP_02079"/>
    </dbReference>
    <dbReference type="GeneID" id="10042394"/>
    <dbReference type="KEGG" id="tba:TERMP_02079"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2076"/>
    <dbReference type="eggNOG" id="arCOG00667">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_1_2"/>
    <dbReference type="OMA" id="FTWLDTG"/>
    <dbReference type="OrthoDB" id="61185at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04189">
        <property type="entry name" value="G1P_TT_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005908">
        <property type="entry name" value="G1P_thy_trans_l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01208">
        <property type="entry name" value="rmlA_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="352" mass="39318" checksum="D18E1454BDA22B8F" modified="2011-05-03" version="1">MKALILSGGHGTRLRPLTYSQQKQLIPVANKPVLFYAIEDVIEAGIHDIGIIVGPNAEQVKKTVMSVDWDANIEFIYQGDPLGLAHAIKVAKDYLGDDDFVMYLGDNILREGIVRHLEHFKKGNFDASILLCEVPNPQQFGVAELSEDGKTIKRLVEKPKVPPSNLALVGIYFFKPVIHEAVKHLKPSWRGELEITDAIQWLIDHGYKVGWTKVTGWWKDTGKPEDILDANRLILDDIERDIRIKTRAKIIGRVVIEEGTEIDENTVIKGPAIIGKNCKIKNAYIGPYTSIGNNCIIENTEIEDSVILEGSEIRCGGRIVESLIGRNVKILEQNNHPIGRRLIIGDNSQLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLZ3</accession>
    <name>F0LLZ3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1616 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02118"/>
    <dbReference type="EnsemblBacteria" id="ADT85092">
        <property type="protein sequence ID" value="ADT85092"/>
        <property type="gene ID" value="TERMP_02118"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02118"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2115"/>
    <dbReference type="eggNOG" id="arCOG02884">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047794_1_0_2"/>
    <dbReference type="OMA" id="IEGNWTP"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011674">
        <property type="entry name" value="DUF1616"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014495">
        <property type="entry name" value="UCP018671"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07760">
        <property type="entry name" value="DUF1616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018671">
        <property type="entry name" value="UCP018671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1616" evidence="2">
        <location>
            <begin position="14"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="331" mass="38101" checksum="B2880BB34B50912E" modified="2011-05-03" version="1">MRIMKWRNYWDLITIIALSLLLDFLIAFFPDSLLRKALGLAFVLFFPGYVFITSLFPNKKELDNLERLALSFGLSIAIVPLIGLGLNYTPWGIRLIPILVSLTIFNLIFGILAVYRRAKAIDPWIPRISIEMLKEELEWDKASKLDKALTVILVIAIISSIATLAYVITHPKPGEKFTEFYILGPNGKAADYPTELFVGENATIILGIANHEYRNVTYYVEVWLVNLTYDFNTNTTHIYNMYLLDRFNVTLPHKPVNIEGNWTPQWEMNYTFSIDKPGKWQLWFLLFKDKEPPLPKPINGDYAQTNATQRILDAIDGKILSLKLNIEVRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM09</accession>
    <name>F0LM09_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="15">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">TERMP_02134</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="15"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468404.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02134"/>
    <dbReference type="EnsemblBacteria" id="ADT85108">
        <property type="protein sequence ID" value="ADT85108"/>
        <property type="gene ID" value="TERMP_02134"/>
    </dbReference>
    <dbReference type="GeneID" id="10042449"/>
    <dbReference type="KEGG" id="tba:TERMP_02134"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2131"/>
    <dbReference type="eggNOG" id="arCOG03151">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04276">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_2_1_2"/>
    <dbReference type="OMA" id="MMATMRC"/>
    <dbReference type="OrthoDB" id="4783at2157"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="5 15" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="13 15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="17">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="16">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ADT85108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1042" mass="118312" checksum="464AF19E25C089DE" modified="2011-05-03" version="1">MAVEKVMKRDGRIVPFDEGRIRWAIQRAMWEVGVRDEKLLDKVVKDVVGRINELYDGKIPHIENIQDIVELELMRNGLFDVAKAYILYRKKKAEIREEKKKILNKDKLDEIDKRFSINALRVLASRYLMKNEEGKIIESPRELFERVAILAVIPDLLYDDRVFSKEGGFAQDLKRVDYYREHLDEFDKKLSIGRFKLNKYHFERFLSLYQELAEKGQMKVSIDEIVKMLEDGAFDKYEKEIEEYFRLMTNQIFMPNTPALINAGRPLGMLSACFVVPIEDDMESIMKAAHDVAMIQKMGGGTGVNFSKLRPEGDLVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRRGANMGILEVWHPDIEKFIHAKEKNIGTNVLSNFNISVGIWEDFWEALKEGRKYPLINPRTGKKVREVDPKALFEELAYMAWAKADPGVVFFDVINRRNVLEKAKGQKIRATNPCVVGDTRILTEKGEIEIEKLFELAKEANIDRLEVLDEGALGERAEKYAYLLPFKVIASNGKPVEAYVWKVGFKPSIKIVLEDGRELTGDEEHKVKVGDNYIELKNIKVGDCIEVFKEGCKKVVEVASVGNQLVYTLTMKEVHEYVANSIISRNCGEEPLYEYESCNLASINLAKFVKYDDEGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSKEGFDFMRKATEYLTFYAYKYSVEAAKKRGTFPLYDKSDYPEGKLPVEGFYHREIWNLPWDELAEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKKRGLYSDELLAKISNNYGSVQGLEEIPEDMQRVFVTAMDVHWLDHILAQASIQLWLTDSASKTINMPNDATVEDVKAAYLLAYKLGCKGVTVYRDGSLSVQVYSVEGEKKKRVPAKPSEYAKSILKEIVEKEPWLRRFIDVEAILNGTNGKNDVSKPSLHLSLDIDVTHQHVQSKTAEAKSGVCPVCGAPTVFESGCEVCKNCGWSKCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM67</accession>
    <name>F0LM67_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467212.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00938"/>
    <dbReference type="EnsemblBacteria" id="ADT83914">
        <property type="protein sequence ID" value="ADT83914"/>
        <property type="gene ID" value="TERMP_00938"/>
    </dbReference>
    <dbReference type="GeneID" id="10042552"/>
    <dbReference type="KEGG" id="tba:TERMP_00938"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.941"/>
    <dbReference type="eggNOG" id="arCOG04046">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1648366_0_0_2"/>
    <dbReference type="OMA" id="GTLWDHE"/>
    <dbReference type="OrthoDB" id="97545at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="157" mass="18500" checksum="6BD203DF0103C28A" modified="2011-05-03" version="1">MRLLILDLDGTLWDHEDASQLVPPFEVHDDTVIDAYGNKLSLFPGVREFLEWAKDRFILSIASWNMEELVRPILEALGLWDYFIFPKIENHPDKASMILRTVEQLKSIGYEVDEIIYIDDRTLHLQDIKREIPNVKFIQMWIDVKSFEELKKVLEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM73</accession>
    <name>F0LM73_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467218.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00944"/>
    <dbReference type="EnsemblBacteria" id="ADT83920">
        <property type="protein sequence ID" value="ADT83920"/>
        <property type="gene ID" value="TERMP_00944"/>
    </dbReference>
    <dbReference type="GeneID" id="10041261"/>
    <dbReference type="KEGG" id="tba:TERMP_00944"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.947"/>
    <dbReference type="eggNOG" id="arCOG00318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069302_1_0_2"/>
    <dbReference type="OMA" id="VDRLYWL"/>
    <dbReference type="OrthoDB" id="38423at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="304" mass="35719" checksum="3795AC7FC2B20A5A" modified="2011-05-03" version="1">MEFRKIQFTGRSSYIISLPKKWIKENNLKQGDVVPLVINPDGSITILPKEPKEISEKKELMISEEYSPDMAIRLIISAYIQGYDVLEIKFTKELPHYKVKIRKVIQSLPGVEIILDEPTRIVGKSLLADEEINLREILERINSIIVSMLEDLYFMKKSQTKELIRDINDLENELDRFYFLTIRAVNKILSKRSLIEESGIVRRSFDLIGILFIVRNIERIGDHIIRIAENFDDDIEIEYIRKMYTEMLSQITKRDLKKIDTLMLALKEKIRQIDYKKSIAMDSYRRILEYLENIGETIINMALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM79</accession>
    <name>F0LM79_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transport protein permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467224.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00950"/>
    <dbReference type="EnsemblBacteria" id="ADT83926">
        <property type="protein sequence ID" value="ADT83926"/>
        <property type="gene ID" value="TERMP_00950"/>
    </dbReference>
    <dbReference type="GeneID" id="10041267"/>
    <dbReference type="KEGG" id="tba:TERMP_00950"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.953"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_1_2"/>
    <dbReference type="OMA" id="FQQAMGI"/>
    <dbReference type="OrthoDB" id="82255at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="5"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="370" mass="40434" checksum="D127D1B043ACFBF7" modified="2011-05-03" version="1">MRKKLLLLLSLGWIFNYAHRMAIPPLIPIIKTELGINNAQAGLLMTSLLLPYALIQVPAGYLGDKLGRKKLVVISILGYSLASALIIFAKEYWELLSIRALYGIFAGLYYAPATALISDIYKGRKGSALGVFMVGPPIGSGIAPLIVVPIALALEWKYAFLVLSAMSAIIGITLLLSIKGELHEVEHAKLRIPKHVIRLSIMNFISMLAFFGMLTFLPDFFVNRGRSLEEASLYFSILSIVGIAGSLVGGTIYDRLKKKSLILSLGFNAFLSFLLAKTAMPIIMPILGLFFYSVGPIVTAYTAEQATNENKGSVMGFVNMMGFFGATLGPYLLGVLIDTLGYGEAFYFIPLMYMVALIIIGTQKKRISHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM82</accession>
    <name>F0LM82_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467227.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00953"/>
    <dbReference type="EnsemblBacteria" id="ADT83929">
        <property type="protein sequence ID" value="ADT83929"/>
        <property type="gene ID" value="TERMP_00953"/>
    </dbReference>
    <dbReference type="GeneID" id="10041270"/>
    <dbReference type="KEGG" id="tba:TERMP_00953"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.956"/>
    <dbReference type="eggNOG" id="arCOG03199">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_4_0_2"/>
    <dbReference type="OMA" id="DDILGWK"/>
    <dbReference type="OrthoDB" id="88899at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="301" mass="32513" checksum="5A58C7164AB89CB9" modified="2011-05-03" version="1">MIWVLAFIGLSLSLILTFYSANIMKKAGIVGKDIHKLDKPEIPEMGGIAILISLSVVLTPVLTGNLSTVLLVFLLFGVVGIIDDLTNLRQSHKVLLSLLISLPLLSLKVSSGLNLLLFTINLKTLYYLFAVLFVTASANLVNMLAGFNGLEVGTSAIALLFLGLITSGDARALAFVGFAVALGFLWWNKYPAKVFPGDTGTLSLGALIGLVGILGKVEIFAAILLVPHMIDFLLKTKIKFKGRPLGRTEILEDGTLKAPPYLSFLGLIMRAKRVKEYELVAIVWAIEAILGFVVLLLHQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM94</accession>
    <name>F0LM94_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00965"/>
    <dbReference type="EnsemblBacteria" id="ADT83941">
        <property type="protein sequence ID" value="ADT83941"/>
        <property type="gene ID" value="TERMP_00965"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00965"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.968"/>
    <dbReference type="eggNOG" id="arCOG05011">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_380666_0_0_2"/>
    <dbReference type="OMA" id="ASKHDEP"/>
    <dbReference type="OrthoDB" id="6612at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="728" mass="81292" checksum="1777BEA7CDCE9013" modified="2011-05-03" version="1">MKKSLLVAILVIFSMATSPIGAHFDPPGQPAVQVNVYFIGMSLSEDMDDGANGYADIIGTYKVTHSGHGTKDGKIDMFYYDWDTLKGKNGYIKKRLLYSHKECSPIKPITVEVGMEEHNTIFSNTQLGSGSITVTKPGIYEIKLDKGKALIEVKVTPAVLYSEKCSYFYDQPPSYASSLVSSSGGYIYDWQLANMIHMWIANRTGYANMVFIFNQCFGGGMIDDLKEKLKGTGDAAFLSASKHDEPAWGLGDDYNPDAFPEVKGKGFEKPEGFYPKEVGEELAKTGKDAPTIKELARRAEMEDIKGPYGLWKKDIERPQYTSVGRGDSIKIGKKADGSDVKSRHAILFAGDADSKRHWNNLDRAYKALKKHGFTDTDIIVLAGNGKTMPDGTNVPGYVDGPGTKKALYEAIVNVSKKMNKNEQLVFWVSDHGNRERIELSILKDIIDPVRQPVPPKRTARRPEQVSWDLDEEFLKVVKLDPDNQPYVSILVEATPEVVEYGEKMFRNIVLYMNGQMLELTMVEPIIAYDGEPDLDAFELVYYMDEELLGEENLIEVEWAGDPEMFIEYTILGLMISTGGINELEAEPVEAVEEQTLFELLKEYVPVYNENADNLPGFIKRIAGNERIDLEISLENGSVLNVGIVTEGGYITEFSKGRISEPTMRAWTDEEVARRIISSEDPMSTATNALKMGEIRYSGVGFGRTLRVFVFKVVIKVYRVVEVIGDLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM96</accession>
    <name>F0LM96_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="5">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">TERMP_02145</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>W-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60537"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468415.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02145"/>
    <dbReference type="EnsemblBacteria" id="ADT85119">
        <property type="protein sequence ID" value="ADT85119"/>
        <property type="gene ID" value="TERMP_02145"/>
    </dbReference>
    <dbReference type="GeneID" id="10042460"/>
    <dbReference type="KEGG" id="tba:TERMP_02145"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2142"/>
    <dbReference type="eggNOG" id="arCOG00709">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_2"/>
    <dbReference type="OMA" id="HDEKWHT"/>
    <dbReference type="OrthoDB" id="9593at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0826">Tungsten</keyword>
    <feature type="domain" description="AFOR_N" evidence="13">
        <location>
            <begin position="4"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADT85119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="624" mass="69681" checksum="2100E7CAE4EEA089" modified="2011-05-03" version="1">MYGYTGKLIDVDLSREKIEVVEIDEGILRKFYGGRGLGTYILWKELGERWEYVDPLGEENLLLILTGPLTGYYPGIKTAVVSKSPESNGVVGSVLSSEVGIELKASGYDGIIIRGKAKEPVYLFVNDDTIEIRDASKYWGMNGVEVVKTLTKDVHEELKKKEKLKGVPKEPAIMYIGRGGENKVRFAAIMAKLMHAAGYGGFGAVMGSKMLKAVVVKGSKALPQVYDREKFKTMLREFQKELLTLTTFRQWGTGAGGYSVGKDRSSQPVKNWQEEYHDNEEISVVNFELKAWIKKYWADYGCPVNCMKISYLRYGPYKGSITDAPDYELMAYMGTNLGIFEPEKIVYLSYLVDEYGLDGINAGNVLGFAAELYQRGILTKEDLGFELKWGDEKAFARLLEMIVNKEGIGKILAEGTYRAALKISEMKGSDALRYAVHVKGIGVGAHGIRSDLDYTKDISYAASVQGGDHTATAGLPARSYEGELVNAFYDSAVICMFVTKPGFERILEFGNAVTGFDLTPEKWFNEAGLRIIHLQRILLLLGGPDVYWDPRKDDDNPPRFYEPLPSGPVKGKAPTKDDIRGKLKQYYQEIGYDENGIPKEEVLEELGIGEAKREVKRIKRRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMB7</accession>
    <name>F0LMB7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_02166</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
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        <source>
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        <text evidence="1 5 9">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="10">
        <location>
            <begin position="184"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
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        <location>
            <position position="69"/>
        </location>
        <ligand>
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        <location>
            <position position="93"/>
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        <ligand>
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        <location>
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        </ligand>
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        <location>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="ADT85140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="420" mass="46979" checksum="D1064D2474CEC225" modified="2011-05-03" version="1">MVEQDPFEIAVKQLERAAQYMDISEEALEFLKRPQRILEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIICNPKELSDREKERLARGYIRAIYDIISPYTDIPAPDVYTNPQIMAWMMDEYEMISRRKTPAFGIITGKPPSVGGIIARMDATARGGAFTVREAAKALGWDTLKGKTIAIQGYGNAGYYMAKIMSEEYGMKVVAVSDSKGGIYNPDGLNADEVLKWKKEHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAKIIAELANGPTTPEADEILYEKGILIIPDFLCNAGGVTVSYFEWVQNITGDYWTVEETRAKLDKKMTKAFWDVYNTHKEKNINMRDAAYVVAVSRVYQAMLDRGWVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMC8</accession>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
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            <taxon>Euryarchaeota</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    <dbReference type="eggNOG" id="arCOG05723">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="YTIFGQP"/>
    <dbReference type="OrthoDB" id="58560at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="O_anti_polymase"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="58"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ADT85151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="346" mass="39957" checksum="887DC159269F17A5" modified="2011-05-03" version="1">MKSLKLFSLAFFTYLVLTLYTNVFLKDKLYGAELDMSRIWVALLVVILFFVFLVAGYLKPAELPAWAYWLMLFVFSFALPLYGVIAVAFIFLFSMKYNPFEKHAHIWLILSIILLGFIYLLRGIPLFNWGLRFGLSKILVFLAFLSGVSLVYVNWSIKFKTLVFLILEMLFFLGTFRSLMLLIFLMYILPLYFEERLTLDKICLAIPVFLLILYLSGSLEGLLVRIGFTFLIFHNLVHISMPFGIFHGKLLLHSDPRWRIAFMFTLKNRYTYFLFGQAVADFGIFGVIEAYFIGTLLKLSERNLKTATIVLSTIIYAIESGIDAFLLSVLILFGALYSKTNIKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LME1</accession>
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    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
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                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
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                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="1">
        <location>
            <begin position="14"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="131" mass="15460" checksum="8693531643A31FFB" modified="2011-05-03" version="1">MRKLRIAFGMENEGKLTDGHYGDSEFFLIYEILEDGTVKLLEKKPNRAKKMEEHESEHGDLRKFRVVIEQLEDVDVLAAFRMGPNFLRIRDQSNKVAFFTSTRDLNLALQRVIESFEELWKQVEEKKSKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LME2</accession>
    <name>F0LME2_THEBM</name>
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        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="7" type="ordered locus">TERMP_02191</name>
    </gene>
    <organism evidence="7 8">
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        <dbReference type="NCBI Taxonomy" id="391623"/>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02191"/>
    <dbReference type="EnsemblBacteria" id="ADT85165">
        <property type="protein sequence ID" value="ADT85165"/>
        <property type="gene ID" value="TERMP_02191"/>
    </dbReference>
    <dbReference type="GeneID" id="10042506"/>
    <dbReference type="KEGG" id="tba:TERMP_02191"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2186"/>
    <dbReference type="eggNOG" id="arCOG00953">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058377_0_0_2"/>
    <dbReference type="OMA" id="CIYCELG"/>
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    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040084">
        <property type="entry name" value="GTPase_Obg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01083">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="10"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT85165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="316" mass="36525" checksum="74992DDAF5AE0D4E" modified="2011-05-03" version="1">MIAFGPVPSRRLGKSLGINNIPDKVCSYACVYCQIGRTIRMEVKRKTFYNPELILKEAKEKLEKARAKGEHVDYITFVPDGEPTLDINLRKETELLKELGTPLAILTNSSLIWREDVREDLLEFDFVSLKLDAVSEQLWRKIDRPHKSLKLNEILNGMLEFRKEFKGKLVTETMLINGVDYGDEFEKISKFLKKLEPDIAYIAIPTRPPAERWVKPASEETINRAFQIFAEALGSDRVEYLIGYEGNAFVFTGNVEEDLLSITAVHPMREDAVEDFLKKANADWSVVEKLLKEEKIIELEYEGRKFYMRKLKSRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMG0</accession>
    <name>F0LMG0_THEBM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468479.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02209"/>
    <dbReference type="EnsemblBacteria" id="ADT85183">
        <property type="protein sequence ID" value="ADT85183"/>
        <property type="gene ID" value="TERMP_02209"/>
    </dbReference>
    <dbReference type="GeneID" id="10042524"/>
    <dbReference type="KEGG" id="tba:TERMP_02209"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2204"/>
    <dbReference type="HOGENOM" id="CLU_661605_0_0_2"/>
    <dbReference type="OMA" id="VEWENGT"/>
    <dbReference type="OrthoDB" id="67983at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="419" mass="48682" checksum="1F3928A2C515B77A" modified="2011-05-03" version="1">MKRFNSLLAERMFIISVLFLFLLPSAAAFERSKVIGGNFTNPLHAEVPPEYRAEWVEFIFDSNETCNASAFYRVYQYGEVVKEGSAEVRWLKNRVSITIPLEIYDEFTVHLFPDFSCNATPERYMIFETIDFRRLTSLKVETERTVETLWKGKAIKASPLKMDFNIPGELLGVEAELYDYKGKFVYVTLSWDGFKKNLTLPVVNSRVWIPGQNASGKIRLILDLPRNVFVSATAYYLTKRKPVNEDLLRNEEKLIRFEYPLGGMIWDEVWLKMLFMVNGDGELIVFDFGNDKRSKMFISKGKVCVNLYTRYSERKKECWPLGERNVHYMIFALNRREDGTRYLRIKVDDLAFSTDVNSGIRLWYLGSAISPLSFDASLRRNPSYYVVPPEQRRISFALGLSFLALSLSTVSIFLVLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMH4</accession>
    <name>F0LMH4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SO_alpha_A3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467251.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00977"/>
    <dbReference type="EnsemblBacteria" id="ADT83953">
        <property type="protein sequence ID" value="ADT83953"/>
        <property type="gene ID" value="TERMP_00977"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00977"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.980"/>
    <dbReference type="eggNOG" id="arCOG01299">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172457_1_0_2"/>
    <dbReference type="OrthoDB" id="15559at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041117">
        <property type="entry name" value="SoxA_A3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17806">
        <property type="entry name" value="SO_alpha_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SO_alpha_A3" evidence="1">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="98" mass="11148" checksum="E963371A227E4655" modified="2011-05-03" version="1">MIKFNLDLEKVNPEEVFICGCDVTLKDILDLIDQGITDIQLIKRLTHVGMGFCQGRYCIDTVAQIIAWKTGKDLKEIKLPVARMPVRPVKMKVMADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMM1</accession>
    <name>F0LMM1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467298.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01024"/>
    <dbReference type="EnsemblBacteria" id="ADT84000">
        <property type="protein sequence ID" value="ADT84000"/>
        <property type="gene ID" value="TERMP_01024"/>
    </dbReference>
    <dbReference type="GeneID" id="10041341"/>
    <dbReference type="KEGG" id="tba:TERMP_01024"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1027"/>
    <dbReference type="eggNOG" id="arCOG07709">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193464_0_0_2"/>
    <dbReference type="OMA" id="YAMGEEA"/>
    <dbReference type="OrthoDB" id="128802at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="83" mass="9476" checksum="5AB0E2A25FFF6868" modified="2011-05-03" version="1">MKVKLVYPEYQIEITEKEVYLFNGRLISAPLDEVIYYAYGKDAVLPEELKKVAHDVLRAFTLFSAESNLSKFALPNFSKSITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMN1</accession>
    <name>F0LMN1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467308.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01034"/>
    <dbReference type="EnsemblBacteria" id="ADT84010">
        <property type="protein sequence ID" value="ADT84010"/>
        <property type="gene ID" value="TERMP_01034"/>
    </dbReference>
    <dbReference type="GeneID" id="10041351"/>
    <dbReference type="KEGG" id="tba:TERMP_01034"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1037"/>
    <dbReference type="eggNOG" id="arCOG00721">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109674_1_0_2"/>
    <dbReference type="OMA" id="GCGREFD"/>
    <dbReference type="OrthoDB" id="102178at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="PTHR12814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="4">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="162" mass="18121" checksum="D92BE35E9AD8CFD6" modified="2011-05-03" version="1">MLIIDAAIFIQGIDVEGYTTPKVIEEVKDPESKLFLESLISAGKVKVLVPSKESIEVIKTKALETGELDELSEADIEVLALAYELKAVLFTDDYNLQNIAKTLGIRFKTLKRGIRKVIRWGYVCIGCNKKFKREPPGGICPDCGSPVRLLPRRKSRKKTKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMS7</accession>
    <name>F0LMS7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase, caspase catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467354.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01080"/>
    <dbReference type="EnsemblBacteria" id="ADT84056">
        <property type="protein sequence ID" value="ADT84056"/>
        <property type="gene ID" value="TERMP_01080"/>
    </dbReference>
    <dbReference type="GeneID" id="10041397"/>
    <dbReference type="KEGG" id="tba:TERMP_01080"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1083"/>
    <dbReference type="eggNOG" id="arCOG05844">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_593999_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="460" mass="51946" checksum="126EBBC39DB611A6" modified="2011-05-03" version="1">MEEKINEILELLPFIDNNSEKMKIISTLLRISHGDQQLLSLGFDTVEAIGDDLTRIQSLLSLATAVKDADVGLYKGLLQMAINETKKLANPKEKAMALSDIAVEVVTFDETLVLKLVEEILTLIFKIELKEDKVAAVMYFLRDLLKSEDIEGAIKVAKKISDPYYRAIAFSEIGKALAEAGIQLYLSVFSQALKSASEIENFVMREMTFGEIISKLAEAGKVDESLNLIEKLRVKEAQIQVLESVILRLISAGNLTKALNLMMLIDDRKKKLKLRALSVSALIKAGHYEEALKIVESLKDQIHKDLALSEMSIALAEKGEFERALQVVGHIRDGYYRGRAFSVIGLELFNRGRDGYQVLFEKAIEEAKTIKNQRLRSQLFVDIALRLATVNLRNQLLDFLNRKIQNAEESAKGGNLERAAREYKEGLELSEIARLKEYSEHFRNRIYEIRRKLVEGIEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMU9</accession>
    <name>F0LMU9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetate--CoA ligase (ADP-forming)</fullName>
            <ecNumber evidence="2">6.2.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15081"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.2.1.13" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467376.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01102"/>
    <dbReference type="EnsemblBacteria" id="ADT84078">
        <property type="protein sequence ID" value="ADT84078"/>
        <property type="gene ID" value="TERMP_01102"/>
    </dbReference>
    <dbReference type="GeneID" id="10041419"/>
    <dbReference type="KEGG" id="tba:TERMP_01102"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1105"/>
    <dbReference type="eggNOG" id="arCOG01340">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007415_2_3_2"/>
    <dbReference type="OMA" id="SFMSQSG"/>
    <dbReference type="OrthoDB" id="15044at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014089">
        <property type="entry name" value="AcCoA-synth-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02717">
        <property type="entry name" value="AcCoA-syn-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="462" mass="49659" checksum="7F51C64A89E28368" modified="2011-05-03" version="1">MSIEALFKPKSVAVIGASGKPGKIGYAIMKNLIEYGYEGKIYAVNIKGGEIEISGRKFKVYKSILDVPDEVDMAVIVVPAKFVPQVVEECGKKGVKVLPIISSGFGELGPEGKKVEEQLVETAHKYGMRILGPNIFGVVYTPAKLNATFGPTDVMPGSLALISQSGALGIALMGWTILEKVGLSAVVSIGNKSDIDDADLLEYFKDDENTKAILIYMEGVKDGRKFMKAAKEVSMKKPIIVIKAGRSERGAKAAASHTGSLAGADSIYTAAFKQSGVLRALTIGEAFDWARTLSNLPEPPGENVVIITNGGGIGVMATDAAEEEGLKLYDNLEELKVFANHMPPFGSYKNPVDLTGMADAKAYEGAVRDALAHPEMHAIAVLYCQTAVLDPRDLARIVIDEYEKSGKKKPIVVAIVGGIEAKEAIDILNENGIPAYPEPERAIKSLAALYRWSRWKASKRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMV4</accession>
    <name>F0LMV4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467381.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01107"/>
    <dbReference type="EnsemblBacteria" id="ADT84083">
        <property type="protein sequence ID" value="ADT84083"/>
        <property type="gene ID" value="TERMP_01107"/>
    </dbReference>
    <dbReference type="GeneID" id="10041424"/>
    <dbReference type="KEGG" id="tba:TERMP_01107"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1110"/>
    <dbReference type="HOGENOM" id="CLU_904950_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="307" mass="34837" checksum="ED79AEDC9A531FD1" modified="2011-05-03" version="1">MKKAAGVIFVLLGAFMLYADHMYFRPPYRCVSAYVLPLPVLEVGVKNITNGEEVYTIILALGIDSNKSEIMVHDSEQNLSVPFIRKGELYYPPEPRYINKITINENASTITVYYLNYYNSSSTNVENISLKISPSAFTLNTTLRIKPTKDGFYLNITLPTGNISINGNPETFIFFGNNITEVPILNEIFIGKVLNATLAYDTHDPVVREKLWLLMDIKVYRGGFEFHTHGLNVQNIKRVELQKGFSFKNLILYDNYTAIERMYDVKSGRYQEECYEYFPGLLAYVGGLVTLLGITLFADAVKHGKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN18</accession>
    <name>F0LN18_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467445.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01171"/>
    <dbReference type="EnsemblBacteria" id="ADT84147">
        <property type="protein sequence ID" value="ADT84147"/>
        <property type="gene ID" value="TERMP_01171"/>
    </dbReference>
    <dbReference type="GeneID" id="10041488"/>
    <dbReference type="KEGG" id="tba:TERMP_01171"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1174"/>
    <dbReference type="HOGENOM" id="CLU_2447815_0_0_2"/>
    <dbReference type="OrthoDB" id="140636at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="89" mass="9790" checksum="023AE656C4203111" modified="2011-05-03" version="1">MSKLAYIFAAMPGFGLMLSSWGKGIVYEKEMCIGFPCYAILIGYILVFVGAAGWILDIKFNTESDEYRKTVALSFLVFFVVGLLAVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN60</accession>
    <name>F0LN60_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
            <plasmid evidence="2 3">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747421.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT85199">
        <property type="protein sequence ID" value="ADT85199"/>
        <property type="gene ID" value="TERMP_02226"/>
    </dbReference>
    <dbReference type="GeneID" id="10549050"/>
    <dbReference type="KEGG" id="tba:TERMP_02226"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2220"/>
    <dbReference type="eggNOG" id="arCOG11296">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1623542_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="163" mass="19133" checksum="BBCDCC0BB2A99D26" modified="2011-05-03" version="1">MGLRKLILGFDPDELHELKTALIRIENIEKEIREVKEHMKELQRLLNDKADKQAVDLLSKMLETERKIVDSLEQELKEIKLKFDTLELSSELAESHKVSIDDFELEERLIKLISQGHNSPTELIRMLGISADKLYQIINRLIASRRIKKIKKGRKVYYVLVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGU4</accession>
    <name>F0LGU4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466281.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00005"/>
    <dbReference type="EnsemblBacteria" id="ADT82983">
        <property type="protein sequence ID" value="ADT82983"/>
        <property type="gene ID" value="TERMP_00005"/>
    </dbReference>
    <dbReference type="GeneID" id="10040324"/>
    <dbReference type="KEGG" id="tba:TERMP_00005"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.5"/>
    <dbReference type="eggNOG" id="arCOG04158">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028916_0_0_2"/>
    <dbReference type="OMA" id="MVRLHWR"/>
    <dbReference type="OrthoDB" id="22332at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050504">
        <property type="term" value="F:mannosyl-3-phosphoglycerate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051479">
        <property type="term" value="P:mannosylglycerate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012812">
        <property type="entry name" value="Osmo_MPG_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09488">
        <property type="entry name" value="Osmo_MPGsynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02460">
        <property type="entry name" value="osmo_MPGsynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT82983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="394" mass="45133" checksum="BE382711720FA788" modified="2011-05-03" version="1">MLLEAPVYKEIFGAVKIYELQKLLKMDTETEEVPMFTVTNIPREDIYRTLGEMAVVVPMKNEKLHLVDGVLKAIPHKCPIIIVSNSKREGPNRYRQEVDLVRHFYNLTHSRIIMVHQKDAGIAKAFEKVGYTAILDENGNVRSGKGEGMVIGILLAKAIGAKYVGFVDADNYIPGAVNEYVKDYAAGFLMSESEYTMVRLHWRHKPKVTKGSLYFKKWGRVSEITNRYLNQLISEQTAFETTIMVTGNAGEHAMTMKLAEIMPFSTGYSIEPYEIVYLLERFGRWEGVEEYQDVFDQGIEIFQIETLNPHFHEDKGQRHVKEMILMSLATIYHSSLASDGLRKKIIEDLRMHNIIGENEEPPEPIIMPPIKDVDDKKWIKIVENHSETLLKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGV3</accession>
    <name>F0LGV3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466290.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00014"/>
    <dbReference type="EnsemblBacteria" id="ADT82992">
        <property type="protein sequence ID" value="ADT82992"/>
        <property type="gene ID" value="TERMP_00014"/>
    </dbReference>
    <dbReference type="GeneID" id="26137867"/>
    <dbReference type="KEGG" id="tba:TERMP_00014"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.13"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_2_1_2"/>
    <dbReference type="OMA" id="GEYDMCV"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT82992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="81" mass="9304" checksum="02C4CD0296F90DC9" modified="2011-05-03" version="1">MKGIMAFLFIKTQPKNRQVPVEDEISRMKGVLHLYEVLGEYDMCVHVHAGTREELSNLLYNISTVEGVKEITTIIISKRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH07</accession>
    <name>F0LH07_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467513.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01239"/>
    <dbReference type="EnsemblBacteria" id="ADT84215">
        <property type="protein sequence ID" value="ADT84215"/>
        <property type="gene ID" value="TERMP_01239"/>
    </dbReference>
    <dbReference type="GeneID" id="10041556"/>
    <dbReference type="KEGG" id="tba:TERMP_01239"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1241"/>
    <dbReference type="HOGENOM" id="CLU_2353357_0_0_2"/>
    <dbReference type="OMA" id="ATYANIG"/>
    <dbReference type="OrthoDB" id="139085at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="96" mass="10541" checksum="091DC86366E06865" modified="2011-05-03" version="1">MRTRDVVILASWLAAIVISAVIIIKGGATYANIGIALLLFFMASGISFAVGYSLYDTEELKLSKELSSLNSKLEKIEKKISSIEGKVEKVEKFLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH50</accession>
    <name>F0LH50_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_00034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466310.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00034"/>
    <dbReference type="EnsemblBacteria" id="ADT83012">
        <property type="protein sequence ID" value="ADT83012"/>
        <property type="gene ID" value="TERMP_00034"/>
    </dbReference>
    <dbReference type="GeneID" id="10040353"/>
    <dbReference type="KEGG" id="tba:TERMP_00034"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.33"/>
    <dbReference type="eggNOG" id="arCOG02248">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052508_2_1_2"/>
    <dbReference type="OMA" id="PWGTSGH"/>
    <dbReference type="OrthoDB" id="92958at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="204" mass="21120" checksum="18267FBA828D0888" modified="2011-05-03" version="1">MHIPDGLLSMPVIVITYIIMVATVAYSAKKLKDFPENKIPLLGLFAAGIFAAQMVNFPIIGGVSGHLLGATLVAILLGPYAAVLVMTAVLIIQTLLFGDGGITALGANILNMGILGAFLGYTVYTKLRNINEIAAIGIASWLSVFLAAVLAAIEIGISKSLPFGKVLTLMAGYHAVIGIGEAILTIIIVQAVRAKLPEIGGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH83</accession>
    <name>F0LH83_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfhydrogenase II subunit b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466343.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00067"/>
    <dbReference type="EnsemblBacteria" id="ADT83045">
        <property type="protein sequence ID" value="ADT83045"/>
        <property type="gene ID" value="TERMP_00067"/>
    </dbReference>
    <dbReference type="GeneID" id="26137919"/>
    <dbReference type="KEGG" id="tba:TERMP_00067"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.67"/>
    <dbReference type="eggNOG" id="arCOG05128">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046702_0_0_2"/>
    <dbReference type="OMA" id="DEYCFCK"/>
    <dbReference type="OrthoDB" id="34322at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17179">
        <property type="entry name" value="Fer4_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="334" mass="39041" checksum="B3783FAAFDF8FBDE" modified="2011-05-03" version="1">MRYVKLPSENFEEFFNSLKNWGTVYAPVKQGNIYSFKQVGTLEEVSLNYTRTMLPPKKFFVKPREILLKLKNGKWEENRKAEKIVLFGVHSCDVHGLQILDKVYLEEPADPYYKERRENTIIIGISCMPDEYCFCKSLGTHFAMHGFDLFLHELPDGWLVRVGSVKGHEIAWANESLFEDIDEEDLKHFKEFEEKRSASFKKHLNKEGLADLLDLAFDSPVWKKYERICLGCGNCNMVCPTCRCYEVCDYWVNAYEAVRVRRYDSCFMESHGLVAGGHNFRPTRLDRFRHRYYCKSYFDPSAGFNCVGCGRCDEFCPAKIEHVKVLDEIREALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHA5</accession>
    <name>F0LHA5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00089"/>
    <dbReference type="EnsemblBacteria" id="ADT83067">
        <property type="protein sequence ID" value="ADT83067"/>
        <property type="gene ID" value="TERMP_00089"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00089"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.89"/>
    <dbReference type="HOGENOM" id="CLU_3178771_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="46" mass="5327" checksum="B461FBA0BC285A94" modified="2011-05-03" version="1">MKKLRFPNKYKIEGKEKVLSLELKNMRGKGSIAPPIAKKKGRVWET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHA9</accession>
    <name>F0LHA9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl23</name>
        <name evidence="8" type="ordered locus">TERMP_00093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Contacts protein L29.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466369.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00093"/>
    <dbReference type="EnsemblBacteria" id="ADT83071">
        <property type="protein sequence ID" value="ADT83071"/>
        <property type="gene ID" value="TERMP_00093"/>
    </dbReference>
    <dbReference type="GeneID" id="26135409"/>
    <dbReference type="KEGG" id="tba:TERMP_00093"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.94"/>
    <dbReference type="eggNOG" id="arCOG04072">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_4_2_2"/>
    <dbReference type="OMA" id="MDPYKVI"/>
    <dbReference type="OrthoDB" id="113971at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_L23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019985">
        <property type="entry name" value="Ribosomal_L23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03636">
        <property type="entry name" value="uL23_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="86" mass="9898" checksum="81077AF43A3D8892" modified="2011-05-03" version="1">MDPYKVIIRPVVTEKAVSLIEKENKLTFIVDRRATKQDIKRAVEEIYNVKVEKVNTLITMKGEKKAYVKLKPEYSASEIAARIGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHD2</accession>
    <name>F0LHD2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467557.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01284"/>
    <dbReference type="EnsemblBacteria" id="ADT84259">
        <property type="protein sequence ID" value="ADT84259"/>
        <property type="gene ID" value="TERMP_01284"/>
    </dbReference>
    <dbReference type="GeneID" id="26136767"/>
    <dbReference type="KEGG" id="tba:TERMP_01284"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1286"/>
    <dbReference type="eggNOG" id="arCOG01009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202919_0_0_2"/>
    <dbReference type="OMA" id="LINAMDQ"/>
    <dbReference type="OrthoDB" id="130007at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="63" mass="7403" checksum="878F112A1912B075" modified="2011-05-03" version="1">MTKMKIISVQIPQGLLNAIDTLVKRGVYPNRSEVIREAIRELIKKELYKLETEERTTPEYILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHF7</accession>
    <name>F0LHF7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467582.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01309"/>
    <dbReference type="EnsemblBacteria" id="ADT84284">
        <property type="protein sequence ID" value="ADT84284"/>
        <property type="gene ID" value="TERMP_01309"/>
    </dbReference>
    <dbReference type="GeneID" id="10041625"/>
    <dbReference type="KEGG" id="tba:TERMP_01309"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1310"/>
    <dbReference type="eggNOG" id="arCOG00826">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_36_0_2"/>
    <dbReference type="OMA" id="VGFIVCD"/>
    <dbReference type="OrthoDB" id="101975at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="166" mass="19774" checksum="EDD576CA58904575" modified="2011-05-03" version="1">MEEEVKIEKLKEFNQELLEKLVDVYMRGYEDMPEYGGEGRRYARRYLRWCWDKAKDGFFIAKIGDEIVGFIVCDRDWFSKYEGKVVGAIHEFVVDKRYQGKSIGKKLMEKCLCYLSKYNDKIELWVGEKNKKAIKFYEKYGFRVVGQSGIWVRMVKDVQNEPQSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHH1</accession>
    <name>F0LHH1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="5">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">TERMP_01323</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>W-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60537"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467596.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01323"/>
    <dbReference type="EnsemblBacteria" id="ADT84298">
        <property type="protein sequence ID" value="ADT84298"/>
        <property type="gene ID" value="TERMP_01323"/>
    </dbReference>
    <dbReference type="GeneID" id="10041639"/>
    <dbReference type="KEGG" id="tba:TERMP_01323"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1324"/>
    <dbReference type="eggNOG" id="arCOG00706">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_2"/>
    <dbReference type="OMA" id="IHIGQFR"/>
    <dbReference type="OrthoDB" id="9593at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0826">Tungsten</keyword>
    <feature type="domain" description="AFOR_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT84298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="605" mass="66831" checksum="28ABACA3196F2C63" modified="2011-05-03" version="1">MFGYQGKILRVNLTTGKISEEKIDENFAKKWLGTRGFGIYFLLKEMDPKAKPFSPENKLIFATGPLTGTTAPTGGRYMVITKSPLTGYIAMANSGGFFGAELKFAGWDAIIFEGKADHPVYLYINDDQVELRDASHIWGKVVSETEKILMEEVGDKRVQIASIGPAGENLVRFAAVMNNGHRAAGRGGVGAVMGSKNLKAVVVRGHKRVEVADRQKFTSVVKEKIEKLKKDPVAGGGLPKYGTAVLVNIINSNGLYPTRNFQDSQFEYAEEQSGEALAAKYLKRNKPCFACPIGCGRVTYHPALGETEGPEYESIWALGANLGINDLASIVIANHLCDEYGLDTISTGGTLATAMELYEKGLIKPEDLGDAPPLRFGNTEVLHYYIEKLTFRKGFGDKLAEGGYRLAEMYNGVEYFMGVKKQELPAYDPRGAEGHGLAYATNNRGGCHIKNYMISPEILGYPYKMDPHDISDEKIKMVILFQDLTALIDAAGLCVFTTFGLGADDYRDMLNAALGWDFTTEEYLKIGERIWNAERLFNLKAGLDPLKEDTLPKRLLEEPVKAGPNKGHVVRLKEMLPRYYALRGWTEEGKVPEEKIKELGLEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHI2</accession>
    <name>F0LHI2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467607.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01334"/>
    <dbReference type="EnsemblBacteria" id="ADT84309">
        <property type="protein sequence ID" value="ADT84309"/>
        <property type="gene ID" value="TERMP_01334"/>
    </dbReference>
    <dbReference type="GeneID" id="10041650"/>
    <dbReference type="KEGG" id="tba:TERMP_01334"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1334"/>
    <dbReference type="eggNOG" id="arCOG00045">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077587_0_0_2"/>
    <dbReference type="OMA" id="YHPCGRC"/>
    <dbReference type="OrthoDB" id="66950at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012096">
        <property type="entry name" value="ATPase_PP-loop_MJ1638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006601">
        <property type="entry name" value="ATPase_UCP006601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="246" mass="27591" checksum="527BBEC429477B12" modified="2011-05-03" version="1">MLKVVGDDFVRRYRLQQSLEALERVRDIIGEQSYERLKALVEYRLFGKDFDRAPINEKIAVAFSAGSDSTATVKILRWTGFDVVPVMVKLPQIREPVLWNAQSYGAVFVEIPDYMEKISKQIEKGAPICGKCHSMIMEAVEEYAIREGIKIVASGDLLSVGSISIYPKGKVVRLNLPAFLAMDKKEAIAILGRKYALGFGCSLWKSAARKSPVLKRFAIQRVLRELRAGAIDDEIATKLILDVLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHI4</accession>
    <name>F0LHI4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467609.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01336"/>
    <dbReference type="EnsemblBacteria" id="ADT84311">
        <property type="protein sequence ID" value="ADT84311"/>
        <property type="gene ID" value="TERMP_01336"/>
    </dbReference>
    <dbReference type="GeneID" id="10041652"/>
    <dbReference type="KEGG" id="tba:TERMP_01336"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1336"/>
    <dbReference type="eggNOG" id="arCOG05733">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113599_0_0_2"/>
    <dbReference type="OMA" id="PKLMAYA"/>
    <dbReference type="OrthoDB" id="99223at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="217" mass="25794" checksum="83473C9293F4C188" modified="2011-05-03" version="1">MEEVFKEIEKRIKRLEAEIELAEQRLKLLEETGAAHKYRIWEKRKDYSEYYLILIALWLVVGMMFLYYIKSRYAQRIPFSLTPYVVLVVILISFPLGYLVWKFMHREAIESPLDYLHKREKSARIVLNEFYLPLKEALKKQDKERLRLLADTLLTNLSLAEAIENINEGNPKIMAYALYLYISRDKYPNLKDDIEEAVALLRNKPLKALMMSLLEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHJ0</accession>
    <name>F0LHJ0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="2">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Spermidine synthase</fullName>
            <shortName evidence="2">SPDS</shortName>
            <shortName evidence="2">SPDSY</shortName>
            <ecNumber evidence="2">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">speE</name>
        <name evidence="7" type="ordered locus">TERMP_01342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467615.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01342"/>
    <dbReference type="EnsemblBacteria" id="ADT84317">
        <property type="protein sequence ID" value="ADT84317"/>
        <property type="gene ID" value="TERMP_01342"/>
    </dbReference>
    <dbReference type="GeneID" id="26136826"/>
    <dbReference type="KEGG" id="tba:TERMP_01342"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1342"/>
    <dbReference type="eggNOG" id="arCOG00050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048199_0_1_2"/>
    <dbReference type="OMA" id="LWPGQSF"/>
    <dbReference type="OrthoDB" id="77175at2157"/>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="PTHR11558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="2">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Spermidine binding" evidence="2">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="278" mass="31915" checksum="A227D455230651BD" modified="2011-05-03" version="1">MHFIEWYPRGYGVAFKIKEKLFETQSSYQRIEIYETEGFGKLLVLEGTVQLVEQGEESYHEPLVHPVMLAHPNPRKVLIIGGGDGGTLREVLKHKTVEKAIMVEIDEMVVEISKIYLGIDRGAFDDPRAEVVIGDGVEYIKRAEEKFDVIIIDSTDPVGPAKQLFSEEFYRHAYEVLNSEGILITQSGSVYLFTNELLDAYSAMKSVFDRVYYFSFPVIGYASPWSFLVGIKGSIDFEKIDMNRAKELELVYYDPERHETLFQMPKYVKELLEGKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHJ1</accession>
    <name>F0LHJ1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467616.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84318">
        <property type="protein sequence ID" value="ADT84318"/>
        <property type="gene ID" value="TERMP_01343"/>
    </dbReference>
    <dbReference type="GeneID" id="10041659"/>
    <dbReference type="KEGG" id="tba:TERMP_01343"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1343"/>
    <dbReference type="eggNOG" id="arCOG05845">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1582982_0_0_2"/>
    <dbReference type="OMA" id="ELITICK"/>
    <dbReference type="OrthoDB" id="92413at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="163" mass="19002" checksum="F05A46597B40E514" modified="2011-05-03" version="1">MTEMSFRKQLFKAIKELKNELEELGRYGTPYLIGEIKKDNGKWEVHLAVSVIEEEIEEFSIEENETLMFICPVRDTRPYKVYMDVISLISNKRLQQEIKPGSVIKGNPRRALKRMGFEILWMHSQNTSEGAYITVWASKRGNKYTITMKVVGEEAKIIEVKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHJ5</accession>
    <name>F0LHJ5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetolactate synthase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467620.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01347"/>
    <dbReference type="EnsemblBacteria" id="ADT84322">
        <property type="protein sequence ID" value="ADT84322"/>
        <property type="gene ID" value="TERMP_01347"/>
    </dbReference>
    <dbReference type="GeneID" id="10041663"/>
    <dbReference type="KEGG" id="tba:TERMP_01347"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1347"/>
    <dbReference type="eggNOG" id="arCOG00811">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1881149_0_0_2"/>
    <dbReference type="OMA" id="GECEMIV"/>
    <dbReference type="OrthoDB" id="111711at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="58"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="135" mass="15197" checksum="16871093E5774E3B" modified="2011-05-03" version="1">MRHYEIVRIKENGKVEIPLEFAYEIGLLKDAYFLVEIDTDLKELHLEMVALPGKKLVEIELVVEDKPGVLAKISGVLGRNRVNILFSEAEELEGIGLAAIVTVVDVSEAKISIEELKDELENIEEVKEITLKILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHM1</accession>
    <name>F0LHM1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps13</name>
        <name evidence="6" type="ordered locus">TERMP_00128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466403.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00128"/>
    <dbReference type="EnsemblBacteria" id="ADT83105">
        <property type="protein sequence ID" value="ADT83105"/>
        <property type="gene ID" value="TERMP_00128"/>
    </dbReference>
    <dbReference type="GeneID" id="26135443"/>
    <dbReference type="KEGG" id="tba:TERMP_00128"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.129"/>
    <dbReference type="eggNOG" id="arCOG01722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_0_0_2"/>
    <dbReference type="OMA" id="IRAYRGI"/>
    <dbReference type="OrthoDB" id="84219at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019977">
        <property type="entry name" value="Ribosomal_S13_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03629">
        <property type="entry name" value="uS13_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="148" mass="17010" checksum="A5FA61BD414B584E" modified="2011-05-03" version="1">MADFRHIVRVAGVDLDGNKQLRWALTGIKGIGINFATMVCRVAGLDPFQKAGYLTDEQVKLIEEILEDPVKHGIPPWAVNRPKDYETGRDMHLIGAKLVMAWREDINRLRRIRAYRGIRHELGLPLRGQRTRSNFRRGTTVGVRRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHM7</accession>
    <name>F0LHM7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps9</name>
        <name evidence="9" type="ordered locus">TERMP_00134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466409.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00134"/>
    <dbReference type="EnsemblBacteria" id="ADT83111">
        <property type="protein sequence ID" value="ADT83111"/>
        <property type="gene ID" value="TERMP_00134"/>
    </dbReference>
    <dbReference type="GeneID" id="26135450"/>
    <dbReference type="KEGG" id="tba:TERMP_00134"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.135"/>
    <dbReference type="eggNOG" id="arCOG04243">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_2"/>
    <dbReference type="OMA" id="FMGQAEA"/>
    <dbReference type="OrthoDB" id="115425at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_A">
        <property type="entry name" value="Ribosomal_S9_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019958">
        <property type="entry name" value="Ribosomal_S9_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03627">
        <property type="entry name" value="uS9_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="135" mass="15243" checksum="FB4B7342E5A5EA23" modified="2011-05-03" version="1">MRIIQTAGKRKTAIARATIREGKGRIRINNKPVEIIEPEIARFTILEPLILAGEEIVSKVDIDVKVQGGGFMGQAEAARVAIARALVEWTGDMNLKEKFMKYDRTMLVGDSRRTEPHKPNRSTKGPRAKRQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHN0</accession>
    <name>F0LHN0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphopyruvate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_00137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466412.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00137"/>
    <dbReference type="EnsemblBacteria" id="ADT83114">
        <property type="protein sequence ID" value="ADT83114"/>
        <property type="gene ID" value="TERMP_00137"/>
    </dbReference>
    <dbReference type="GeneID" id="10040455"/>
    <dbReference type="KEGG" id="tba:TERMP_00137"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.138"/>
    <dbReference type="eggNOG" id="arCOG01170">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_817891_0_0_2"/>
    <dbReference type="OMA" id="IDSYLWE"/>
    <dbReference type="OrthoDB" id="29605at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="6">
        <location>
            <begin position="124"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="341" mass="37582" checksum="D40286B1E1EEEBA1" modified="2011-05-03" version="1">MTIIENVVGRVTILRGGKYSIEVDVITSSGFGRFAAPVDENPSLYIVEAHRAVSEVDEIIGPELIGFDAQEQELIDSYLWEIDGTDNLSHIGANTALAVSVAVAKAAANVKKMPLYSYIGGTFTTELPVPLIGFASDEAFEYYVMVRDLMEITDVVDAMVKIEEHAEKTSVEELSKASEAASDELGLDIAIGIVQKRPLELEEVLRTVEDNNIAYIKPLGGEELFLELIASTHGVFVDGEYLFKEKDIIDRRYYNALSIKPINFGTLTDLYNLVNDAKSERITPILAEAKFESADEALPHMAVGLKCPAIMLYKDSLVKINELIRIAEDLGERGRIITFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHN9</accession>
    <name>F0LHN9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease J</fullName>
            <shortName evidence="8">RNase J</shortName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnj</name>
        <name evidence="10" type="ordered locus">TERMP_00146</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466421.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00146"/>
    <dbReference type="EnsemblBacteria" id="ADT83123">
        <property type="protein sequence ID" value="ADT83123"/>
        <property type="gene ID" value="TERMP_00146"/>
    </dbReference>
    <dbReference type="GeneID" id="10040464"/>
    <dbReference type="KEGG" id="tba:TERMP_00146"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.147"/>
    <dbReference type="eggNOG" id="arCOG00546">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008727_4_1_2"/>
    <dbReference type="OMA" id="KNTCVFE"/>
    <dbReference type="OrthoDB" id="12384at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01492">
        <property type="entry name" value="RNase_J_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030879">
        <property type="entry name" value="RNase_J_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001587">
        <property type="entry name" value="RNase_J_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01292">
        <property type="entry name" value="UPF0036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="14"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="378"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="441" mass="49367" checksum="80E32E369F87E6C5" modified="2011-05-03" version="1">MINIYTLGGYEEVGKNMTAVEYNGEVVIIDMGIRLDRVLIHEDVEFQKMPSKELRKIGAIPDDTPIRNKKVVAIAFSHGHLDHIGAIAKLAPHYPDVPIYGTSYTIKLAKSEVKSEQYFEVKNPMYETQYGEIVQVSENLAIEFVQITHSIPHSSIVVVHTPEGAVVYACDYKFDNNSPLGEKPDYKRLKEIGKEGVKVLIAESTRVAEQTKTPSEAVAKMLLEDFFYYDGMDEKGLIATTFASHIARLQELIEIANNIGRQAILVGRSLAKYTGIAKQLGLIKMKGSRVLRSPNAVQKVLREVSQARENYLLIVTGHQGEPGAVLTRMANGELYNIGKDDTVVFSAGVIPNPLNIAQRYALETKLKMKGVRMVKNLHVSGHASREDHRYLIKMLNPENIVPAHGEFRMLTHYAELAEEEGYLIGRDVFVSRNGYKVEISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHS9</accession>
    <name>F0LHS9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00186"/>
    <dbReference type="EnsemblBacteria" id="ADT83163">
        <property type="protein sequence ID" value="ADT83163"/>
        <property type="gene ID" value="TERMP_00186"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00186"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.187"/>
    <dbReference type="eggNOG" id="arCOG02991">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3021156_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="55" mass="6631" checksum="8193AB401BAF95C6" modified="2011-05-03" version="1">MNKFLGKKWEYWFIPINNATIKINDKIVFVQPKEDGIMKIEIRRVPILLIISRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHW2</accession>
    <name>F0LHW2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHOCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01387"/>
    <dbReference type="EnsemblBacteria" id="ADT84362">
        <property type="protein sequence ID" value="ADT84362"/>
        <property type="gene ID" value="TERMP_01387"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01387"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1387"/>
    <dbReference type="eggNOG" id="arCOG03911">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159099_2_2_2"/>
    <dbReference type="OMA" id="LMNGWGY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="96" mass="11259" checksum="3BF90BA6F9CBAA08" modified="2011-05-03" version="1">MFESTELVRFSAHTGETRWGWHDMMGFGYFGIFGALLMLLFWIAIIAGVVWFIKWLFEQSSGGSRKSALEILDEKYARGEIDDEEYERRKRKLLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHY9</accession>
    <name>F0LHY9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467687.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01414"/>
    <dbReference type="EnsemblBacteria" id="ADT84389">
        <property type="protein sequence ID" value="ADT84389"/>
        <property type="gene ID" value="TERMP_01414"/>
    </dbReference>
    <dbReference type="GeneID" id="25394640"/>
    <dbReference type="KEGG" id="tba:TERMP_01414"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1414"/>
    <dbReference type="eggNOG" id="ENOG502N57D">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1286380_0_0_2"/>
    <dbReference type="OrthoDB" id="105003at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="SSF55856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="119"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="207" mass="22412" checksum="C3BEE80C75238217" modified="2011-05-03" version="1">MKRVIKALIISGELLIVVSLALMVTGLAMNDPASTLGSLISYETARRAHTIASYLFIPLFYVHTAAGLLVIANRTERLKTGKAKRALVGAWTVLTVLLVVAGFTAFGTGRLALGSVQATAVLTLEEVAKHSNENDCWVVVENRVYNVTSLIDTHPGGRDAILKYCGTNATEVFFLEHNQNDYEALQAYYIGTINEPIVNQGNGTEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHZ3</accession>
    <name>F0LHZ3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-S cluster assembly SufB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467691.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01418"/>
    <dbReference type="EnsemblBacteria" id="ADT84393">
        <property type="protein sequence ID" value="ADT84393"/>
        <property type="gene ID" value="TERMP_01418"/>
    </dbReference>
    <dbReference type="GeneID" id="10041734"/>
    <dbReference type="KEGG" id="tba:TERMP_01418"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1418"/>
    <dbReference type="eggNOG" id="arCOG01715">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_1_2"/>
    <dbReference type="OMA" id="YYSAPKQ"/>
    <dbReference type="OrthoDB" id="19042at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="52"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="475" mass="53410" checksum="A4956BF3E01F98BB" modified="2011-05-03" version="1">MGQQSRLEEILKAGSLEEILGTAVSYPKEIELKGELTKDMIEELSRIKNEPEWMLRHRLKALELFHKLPMPKWVVGIEELDLESLTLYSKPEIGSEVRDWDDLPENIRRTFERLNIPEIEKKFLSGLTAVFDSESVYSKLKEEFEKKGIIMLPMEEAVQRYPDLVKKYFGRVFPAGEHKFSALHHALWSGGVFVYVPKGVRIPFPVEAFFVIGSALEGQFEHTLLVADEGSYIHFIEGCSAPMYKGFSFHDGMVEIYAHKNATVKFTTIQNWSRNVINFNNKRAIIEENAYVEWIEGSIGSKITYTYPSSILRGEGARTAQYVVSLSNGPYLKDTGAKTVHLAPNTSSKIVSKSISANGGINIYRGLVRILKGAKNSTATVSCDSLILDEESRAYTYPHNQSDEPTASIIHEATTGKLGEDKLFYMNSRGISEEEAKSLIVLGFISEILEGLPFEYVEVLKKVIELEFSEVGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHZ6</accession>
    <name>F0LHZ6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ThiF-like sulfur carrier protein adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467694.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01421"/>
    <dbReference type="EnsemblBacteria" id="ADT84396">
        <property type="protein sequence ID" value="ADT84396"/>
        <property type="gene ID" value="TERMP_01421"/>
    </dbReference>
    <dbReference type="GeneID" id="10041737"/>
    <dbReference type="KEGG" id="tba:TERMP_01421"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1421"/>
    <dbReference type="eggNOG" id="arCOG01676">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_10_1_2"/>
    <dbReference type="OMA" id="LGSWEVY"/>
    <dbReference type="OrthoDB" id="86909at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="8"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="319" mass="36052" checksum="64D82418261F0987" modified="2011-05-03" version="1">MEIFSRHFPIIGLEGQKKLMKSKVAVVGAGALGSWEVYFLKKVGVGEIIVVDRDFVDYNDLPRTIYDEEDVEKPKVEVLKEKFGVKGYFEDLNPSTVNLLDEADLILDGTDNIYTRQVINDYAVKTGKPWIYVGVLSTYGNIMPIIPGKTACFRCLMPKLPSRPMPTCAVAGIMSYVPPLAASLAVALAVKILLGEEVKSEMIFFDTKTLDFEKIEIPRRDDCEACIRHNFTFLEKQMKIERMCDGSIQVTPPEKMSVNLDDLAKRLEALGKEYLKTPQFIQFEDDYAEILIFKSGRMVVRGVEDEKEAKNFFARYLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIA3</accession>
    <name>F0LIA3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467731.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01458"/>
    <dbReference type="EnsemblBacteria" id="ADT84433">
        <property type="protein sequence ID" value="ADT84433"/>
        <property type="gene ID" value="TERMP_01458"/>
    </dbReference>
    <dbReference type="GeneID" id="10041774"/>
    <dbReference type="KEGG" id="tba:TERMP_01458"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1458"/>
    <dbReference type="eggNOG" id="ENOG502N57G">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1307874_0_0_2"/>
    <dbReference type="OMA" id="CLEMNET"/>
    <dbReference type="OrthoDB" id="104280at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="210" mass="23682" checksum="D6B4F5E2432A7844" modified="2011-05-03" version="1">MKSYFAVAIIFVVLALLFGTFSLERSKNAAINESSATHVNFSNSCIHPGYGEFNVHNILFNTSEKLPPETVFRVAMPRNTTIRIKGIIFAKEYAVKEATSPRDVNKTKCYYDGKAKLKAFIGEPNLGDAWSTIQEKLKEPEELEVEIIPSEVDISLEKNATFEVKINTKNAEEGKTYYIYIVAFGERGWKSWAEIEVKIWKITASSTPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIA4</accession>
    <name>F0LIA4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TldD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01459"/>
    <dbReference type="EnsemblBacteria" id="ADT84434">
        <property type="protein sequence ID" value="ADT84434"/>
        <property type="gene ID" value="TERMP_01459"/>
    </dbReference>
    <dbReference type="GeneID" id="10041775"/>
    <dbReference type="KEGG" id="tba:TERMP_01459"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1459"/>
    <dbReference type="eggNOG" id="arCOG00321">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_2_2"/>
    <dbReference type="OMA" id="TDFWGSM"/>
    <dbReference type="OrthoDB" id="22382at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="108"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="222"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="455" mass="50975" checksum="DF15E5D8E58BBD08" modified="2011-05-03" version="1">MEIERLMKKAEELARRYGINYYEVRIVKINATHLEMQNSHLEELSSNMEIGIGVRAFQGAWGFSSANDMRRAEKAIETAMKIAKLMKGGSKVYLDDPIKDKAEIEAKKPFTDVDLEEKLELVKMVDKFLSGDGIVNRKVTYGDGLKWQFYFNSLGSEIETTVPRIRLSFSATAKKGKDMQSYWKIFGGTGGWEIIDRVDLEYWTDFVKEKAKSLLDAQLPPSGEFDVIMDPELAGVFIHEALGHASEGDAIKNGESILEGKLGEKIAVEELTVVDDPTMEGKFGSYIYDDEGIKAKRVEIIKNGVLNEYLLDRETATYLNMQPNGHGRAQSYNYQPLVRMSNTYIEPRDWSFEEMLSEVKHGLYLIGDKGGEVDIANGTFMFGAKEGYLIENGEIKAHIRDVALSGKILDVLKNIRAIGKDLKVEFPGYCGKGQWVPVDDGGPHILTRALVGGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIB9</accession>
    <name>F0LIB9_THEBM</name>
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        <submittedName>
            <fullName evidence="2">Membrane bound hydrogenase beta (NADH dehydrogenase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467747.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01474"/>
    <dbReference type="EnsemblBacteria" id="ADT84449">
        <property type="protein sequence ID" value="ADT84449"/>
        <property type="gene ID" value="TERMP_01474"/>
    </dbReference>
    <dbReference type="GeneID" id="10041790"/>
    <dbReference type="KEGG" id="tba:TERMP_01474"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1474"/>
    <dbReference type="eggNOG" id="arCOG01552">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097415_1_0_2"/>
    <dbReference type="OMA" id="YPWRRDE"/>
    <dbReference type="OrthoDB" id="101801at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="1">
        <location>
            <begin position="43"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="184" mass="21568" checksum="EA5E477E6C21BD5F" modified="2011-05-03" version="1">MNVEEVIEKLEKSLGDALLNYEIREYEMGIRRKRKLYEVWAEIDRSAFRKAVETIFSLDYPHLHLISGEDNGGDSIKMIYSFGVFYSNPWGEVSITLKFDLPKDSLILPTITDLMPGAETNEREIREMLGIEFEGLKNKRHLFLPDDWPEGKYPWRRDEYGVEDMIKHTHKSVREIRKKGEGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIH1</accession>
    <name>F0LIH1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83245">
        <property type="protein sequence ID" value="ADT83245"/>
        <property type="gene ID" value="TERMP_00268"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00268"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.268"/>
    <dbReference type="HOGENOM" id="CLU_2597922_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="79" mass="8849" checksum="CF9ACEB35FCEFAD0" modified="2011-05-03" version="1">MARCMFNGASKIPISGNENEIDVIDFIFSTSSFARNSEEYLPNATAKKLSGIATRNAWEIREFADPKVSTPNFLEMIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIH5</accession>
    <name>F0LIH5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TtuB-like tartrate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466547.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00272"/>
    <dbReference type="EnsemblBacteria" id="ADT83249">
        <property type="protein sequence ID" value="ADT83249"/>
        <property type="gene ID" value="TERMP_00272"/>
    </dbReference>
    <dbReference type="GeneID" id="10042541"/>
    <dbReference type="KEGG" id="tba:TERMP_00272"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.272"/>
    <dbReference type="eggNOG" id="arCOG00535">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_9_4_2"/>
    <dbReference type="OMA" id="IEWREGM"/>
    <dbReference type="OrthoDB" id="122076at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="67" mass="7339" checksum="E4B856C7F96F2D11" modified="2011-05-03" version="1">MIRVRVIGRKIEKEIEWQKGMKVADVLRAVGFNTESAIAKVNGKVALEDDPIKDGDYVEVIPVVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIK4</accession>
    <name>F0LIK4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466576.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00301"/>
    <dbReference type="EnsemblBacteria" id="ADT83278">
        <property type="protein sequence ID" value="ADT83278"/>
        <property type="gene ID" value="TERMP_00301"/>
    </dbReference>
    <dbReference type="GeneID" id="10040619"/>
    <dbReference type="KEGG" id="tba:TERMP_00301"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.301"/>
    <dbReference type="eggNOG" id="arCOG01804">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053800_0_0_2"/>
    <dbReference type="OMA" id="AIAIWEP"/>
    <dbReference type="OrthoDB" id="114594at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014466">
        <property type="entry name" value="Txn_rg_UCP012876"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012876">
        <property type="entry name" value="Txn_rg_UCP012876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="334" mass="38152" checksum="9ACB960060DEE13A" modified="2011-05-03" version="1">MSAKNDILKYLKSKGHDGALQSELYNLGYSRSTIAEALEALEKEKLIVKKNIGKKAYRIWAIDEAPFPIKNTLRLGILRAVEYPHALLTAYDLREKYNVRVLVYNSALELTNALAIGKVDLACSPLITQLLYSLLMKSIKIVSGCGFAGSGLVVRGELEEGKTIASSELSTMETMLKLFLEKGGLKNIKVTYFKNPENAVRSFLSGEIDGISIWEPYLSLLKKKGFDVYHYSNYFGKYPCCALGVNLSFLDVNKDIFKEFFERFKYNTENLEKRKEEAIRLMVEVMGFEEKLVRESFGGFVYDYRLTKKQVEEMLNRFGLKVFNLEKLFLSQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIN9</accession>
    <name>F0LIN9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dipeptide transport system permease DppB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467789.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01516"/>
    <dbReference type="EnsemblBacteria" id="ADT84491">
        <property type="protein sequence ID" value="ADT84491"/>
        <property type="gene ID" value="TERMP_01516"/>
    </dbReference>
    <dbReference type="GeneID" id="26137027"/>
    <dbReference type="KEGG" id="tba:TERMP_01516"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1516"/>
    <dbReference type="eggNOG" id="arCOG00751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_1_2"/>
    <dbReference type="OMA" id="FLMVNVM"/>
    <dbReference type="OrthoDB" id="61149at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="333" mass="37303" checksum="868551333EF06734" modified="2011-05-03" version="1">MADLKKFLIRRVLTFIPTIVGVTIIVFLIAYVIPADPAKAWAGGEKASPEAVERIKERYHLNEPWYDQYWFLIKGLATNTLIDPRTSNPVFDDIKDRFPVTFQLAIIAFTFTILIGIPLGLISALKRNTWIDTLVRIFALIGVSTPVFWLGYLLLFVFFVKFRITNLAGVPPAPPVQITHIPIIDSLLTGNFTLFKQHLARFWLPGFVLGFMGTGVLARFVRNSFLEALSGDYIQFLKAKGVPKLRMYRHALKNALVPIVTVLGLQFGGLLAGTPITETVFALPGMGRYAILSIQNLDFPAVVAITFIYAIIYVTANLVVDILYAVIDPRVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIV8</accession>
    <name>F0LIV8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable aminomethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gcvT</name>
        <name evidence="8" type="ordered locus">TERMP_01585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01585"/>
    <dbReference type="EnsemblBacteria" id="ADT84560">
        <property type="protein sequence ID" value="ADT84560"/>
        <property type="gene ID" value="TERMP_01585"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01585"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1585"/>
    <dbReference type="eggNOG" id="arCOG00756">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_10_2_2"/>
    <dbReference type="OMA" id="MPVQYPA"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="6">
        <location>
            <begin position="6"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="7">
        <location>
            <begin position="310"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="397" mass="45321" checksum="B2B1EEF93FAB7C8E" modified="2011-05-03" version="1">MKRVHLFDWHKEHAKKVEEFAGWEMPIWYSSIKEEHLAVRNGVGIFDVSHMGEIFFRGKDALKFLQYVTTNDISRPPAISGTYTLVLNERGAVKDETLVFNMGNDTYMMVCDSDAFEKLYAWFMSIKRAIEQYTELDLEIENKTYDMAMFSIQGPKAKDIAMELFGIDINQLWWFQAKEVELDGIKMLLSRSGYTGENGFEVYFEDANPYHPDPEKRGKPEKALYVWEKILEVGAKYGIKPAGLGARDTLRLEAGYTLYGNETKELQLLSTDIDEVTPLQANLEFAIFWDKEFIGKDALLKQKERGLPSKMVHFKMVDKGIPRAGYKVYKDGKEIGEVTSGTMSPLLGIGIGIAFVKPEYAVPGVEIEIEIRGQKKKAVTVSPPFYDPKKYGAFREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIZ2</accession>
    <name>F0LIZ2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron(II) uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466636.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00361"/>
    <dbReference type="EnsemblBacteria" id="ADT83338">
        <property type="protein sequence ID" value="ADT83338"/>
        <property type="gene ID" value="TERMP_00361"/>
    </dbReference>
    <dbReference type="GeneID" id="26135705"/>
    <dbReference type="KEGG" id="tba:TERMP_00361"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.361"/>
    <dbReference type="eggNOG" id="arCOG01868">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_4_4_2"/>
    <dbReference type="OMA" id="TRIEINT"/>
    <dbReference type="OrthoDB" id="109456at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="125" mass="14441" checksum="D6CE270E38014F5D" modified="2011-05-03" version="1">MWKKNALKRLKEKGYKLTPQRLKLVEILDRIGSEHPSLKEVLDEIREEFPTVSFSTLYSNVLTLKELGLLELFSLDGETRVELNTEPHINLISGGKVIDFNDPEIIERIREKTGRKVKLVNVILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ34</accession>
    <name>F0LJ34_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466678.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00403"/>
    <dbReference type="EnsemblBacteria" id="ADT83380">
        <property type="protein sequence ID" value="ADT83380"/>
        <property type="gene ID" value="TERMP_00403"/>
    </dbReference>
    <dbReference type="GeneID" id="26135744"/>
    <dbReference type="KEGG" id="tba:TERMP_00403"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.403"/>
    <dbReference type="eggNOG" id="arCOG01641">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182721_0_0_2"/>
    <dbReference type="OMA" id="PKYGFAS"/>
    <dbReference type="OrthoDB" id="125987at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="2">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="80" mass="8879" checksum="BE45168E32A57B0F" modified="2011-05-03" version="1">MENRKFGGKKFDRSRSRGRQPPVKVGERYKVKIEALGKGGDGIARIKGFVVFVPQTKIGDEVEIVINSVKQKFAFGEVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ38</accession>
    <name>F0LJ38_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466682.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00407"/>
    <dbReference type="EnsemblBacteria" id="ADT83384">
        <property type="protein sequence ID" value="ADT83384"/>
        <property type="gene ID" value="TERMP_00407"/>
    </dbReference>
    <dbReference type="GeneID" id="10040725"/>
    <dbReference type="KEGG" id="tba:TERMP_00407"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.407"/>
    <dbReference type="eggNOG" id="ENOG502N588">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1870842_0_0_2"/>
    <dbReference type="OrthoDB" id="128207at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="136" mass="15269" checksum="3C1D0200A647BCF7" modified="2011-05-03" version="1">MNLGVVFAIVIGLLIGMFIPKLMERHREWGRFVILLMMVGIALANWKAGSVRDAYIYFEIVVWLLFGLVSYVEEFGIKVMMTLLLIAVGILGLTLYRLEATITDILGLVVSTVVALYGFAYLGDLVNQRRAEKPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ47</accession>
    <name>F0LJ47_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467867.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01594"/>
    <dbReference type="EnsemblBacteria" id="ADT84569">
        <property type="protein sequence ID" value="ADT84569"/>
        <property type="gene ID" value="TERMP_01594"/>
    </dbReference>
    <dbReference type="GeneID" id="10041910"/>
    <dbReference type="KEGG" id="tba:TERMP_01594"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1594"/>
    <dbReference type="eggNOG" id="arCOG10995">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_788992_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="351" mass="41390" checksum="1E4036E891327C2E" modified="2011-05-03" version="1">MAQLKETLFTNFVKILSSISFLTANLVIFWVLLEFSSLRYKDLFQKGAFLLVGFILTVVFIRPNWLLAFFKNSESQSKIYSHSILKSLFSLRWNGPKIAILIIPRTLFFTTLNYMFLVLIVWVGYFWIATLVGLVHWDPNNLSILFGILSIIGILSGLFQFYFRYYREEVLEKISDAIGDYLKQFVDEISPKAFLEFLKNKKPHLYNKIRQKTFAELFGALPQWIRMRRESGKNISNIIVPYLPQEYTIIWGIENILDESEKQELMKVYEEFFTLKVERIKKKINEIDVSDIREVFILNPFLVDDIWMMMTKIKYEIPPTEENPATFKDYMLNAVGEILLYFTKKVTGEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ53</accession>
    <name>F0LJ53_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467873.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01600"/>
    <dbReference type="EnsemblBacteria" id="ADT84575">
        <property type="protein sequence ID" value="ADT84575"/>
        <property type="gene ID" value="TERMP_01600"/>
    </dbReference>
    <dbReference type="GeneID" id="10041916"/>
    <dbReference type="KEGG" id="tba:TERMP_01600"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1600"/>
    <dbReference type="eggNOG" id="arCOG00150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_15_1_2"/>
    <dbReference type="OMA" id="NWLWINP"/>
    <dbReference type="OrthoDB" id="16335at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="439" mass="49094" checksum="618B62476C7A83F3" modified="2011-05-03" version="1">MSKRRQLFVYLIIGILATAVVSGCISQKETTPTATQAQKEVLEIYHWWTAGGEKEAFDALAKKFQEKYPNIEIKANPVSGGAGVNMKMILQSLMLAGKPPDTFQVHAGYEMARYIKANQLSPIDDIWTDDMKKNYPDVIEQMVIFNNHYYAVPINVHRANVIWYNKKIFEKYGIDPASIKTIDDLFAVAEKLKKNGVTPFALGDRNKWPATQVFEVMLVAVGGIDYYQKFINGEISDNDPTLKKVLEYFVKYIEYSNPDHAAKTWDEACAMVYKGEAAMTLMGDWANGYFKAKGWKPDVDYGAIPIPAGVYDLVIDTFVLPAKAAHPDAAKKWLSFIGTVEAQNTFNPIKGSIPPRMDAPADPYDPIQKAFMKELKSPETKMIPSIAHGSAVPEAFAADLNDIISELATSKDVNKAMTEIINAMKKDLLPNKIKEWKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ76</accession>
    <name>F0LJ76_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">DNA polymerase</fullName>
            <ecNumber evidence="2 10">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">TERMP_01623</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 10"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467896.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01623"/>
    <dbReference type="EnsemblBacteria" id="ADT84598">
        <property type="protein sequence ID" value="ADT84598"/>
        <property type="gene ID" value="TERMP_01623"/>
    </dbReference>
    <dbReference type="GeneID" id="10041939"/>
    <dbReference type="KEGG" id="tba:TERMP_01623"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1623"/>
    <dbReference type="eggNOG" id="arCOG00328">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_6_0_2"/>
    <dbReference type="OMA" id="YAHNSYY"/>
    <dbReference type="OrthoDB" id="35869at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
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        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="12">
        <location>
            <begin position="529"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="11">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT84598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1138" mass="132463" checksum="7F3EDAE7CED8C5BD" modified="2011-05-03" version="1">MILDTDYITKDGKPIIRIFKKENGEFKIELDRNFQPYIYALLESDDAIEEVKKITAKRGNKTVRVLKAEKVQKKFLGRPIEVWKLIFEHPQDVPAIREKIREHPKVIDIFEYDIPFAKRYLIDKGLIPMEGDEELKLLAFDIETFYHEGEQFGEGEIIMISYADENEAKVITWKKIDLPYVEVVSSEREMIKRFVQIIREKDPDVLITYNGDNFDLPYLIKRAQKLGLRLFISRDKENPEPKIQRMGDRFAVEIKGRIHFDLFPVVRRTINLPTYTLEAVYEAVLGKKKTKLEAAEITAIWESEEGMKELAKYSMEDAKATYELGREFFPMEAELARLIGQSVWDVSRSSTGNLVEWFLLRIAYQRNELAPNKPSDEEYQRRLRTTYLGGYVKEPERGLWENIVYLDFRCHPADTKVVVKGKGIVNISEVREGDYVLGINGWHKVLKVWEYDYDGELVNVNGLKCTPNHKLPVVTQKKRQTVIRDSYAKSMLTNKVKGRIIATHLFESIGEIEKRKSEFSEEFILKSELAGIILAEGHLLRKDIRYFDSSRRRHRVSHQYRVAITVNEDEKELIDRINYIFEKLFGCKPSIKRKKNSKALTLQCAKKSVYLEIENIMREIENLDAASVLRGFFEGDGTINTVRRTVVANQGTRNKKKIELVSKLLNKLGIRHSTYTYTDEKNGKRYTRYIIEIPWRGELVKFAILVGFISTRKKELLKQIIEQKEMYQIENSGFYRLNEIHATKEYYKGKVYDLTLDGAPYYFANGILTHNSLYPSIIITHNVSPDTLEREGCKNYDVAPIVGYKFCKDFKGFISSILEELIETRTKIKKEMKATIDPIKRKMLDYRQKAVKLLANSHYGYMGYPKARWYSKECAESVTAWGRTYIEMTIKEIEEKFGFKVLYADTDGLYATIPDADAETIKKKAKEFLKYINSKLPGLLELEYEGFYLRGFFVTKKRYAVIDEEGKITTRGLEVVRRDWSEIAKETQAKVLEAILKDGSVEKAVEIVKKVVEDLAKYKVPLEKLVIHEQITKSLDEYKATGPHVAVARRLKAKGIKVRPGMIISYIILKGDKKISDRAILLSEYDPKKHKYDPDYYIEHQVLPAVLRILEAFGYRKEDLRYQKTKQLGLGAWLNVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ78</accession>
    <name>F0LJ78_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467898.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01625"/>
    <dbReference type="EnsemblBacteria" id="ADT84600">
        <property type="protein sequence ID" value="ADT84600"/>
        <property type="gene ID" value="TERMP_01625"/>
    </dbReference>
    <dbReference type="GeneID" id="10041941"/>
    <dbReference type="KEGG" id="tba:TERMP_01625"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1625"/>
    <dbReference type="eggNOG" id="arCOG05094">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815405_0_0_2"/>
    <dbReference type="OMA" id="AYGHWGN"/>
    <dbReference type="OrthoDB" id="32943at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024508">
        <property type="entry name" value="DUF3226"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11536">
        <property type="entry name" value="DUF3226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="334" mass="38330" checksum="DE7ED5397808AFE6" modified="2011-05-03" version="1">MRIVTGKRYENFKDAVFFPEHGKNSEELKKFVSSLEGEETVVTASLELIDLILERFKRTESGELLYSDTMKSLTLKEAYELRKYLDFDLRGASFGGFSKVSIIFCEGKTDSKFFKGVYKKLFGFKESRTTPENLKLIEKVFERDNFELLRKDDVFLAIIPSEGNAGVIRNLGNFLKAMDVFEFKVDKIGLAIDIDESAEGVMESIRGKLSSFKFTREGGNFRVGDVVIVPLLIGYHFRHPCVEWKKPTVEDLMLKLLEKQGVLRKIERAINILCIDLKRKLKPKEVIYLALASYGFWGNLEGFYEMFVMRSRKKNLEEILSAAGLLDKLAEVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ81</accession>
    <name>F0LJ81_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01628"/>
    <dbReference type="EnsemblBacteria" id="ADT84603">
        <property type="protein sequence ID" value="ADT84603"/>
        <property type="gene ID" value="TERMP_01628"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01628"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1628"/>
    <dbReference type="eggNOG" id="arCOG02008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1943968_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="136" mass="14864" checksum="FD01A541345ED2FC" modified="2011-05-03" version="1">MGILGIVFSLAAVRYFGSNMMHILTVAMAFLIAVGIFPEEYGKIHSIPAILFYLLSLTGIFYAGVILRKRGKQKLSLFSMIGSAGTFALMIATLGKSGLAVPEMIGAVFILSWIVVISHKMLKETKRKESNIKSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJF0</accession>
    <name>F0LJF0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="13">ATP-PRT</shortName>
            <shortName evidence="13">ATP-PRTase</shortName>
            <ecNumber evidence="5 13">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hisG</name>
        <name evidence="15" type="ordered locus">TERMP_00439</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the ATP phosphoribosyltransferase family. Short subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5 13"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466714.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00439"/>
    <dbReference type="EnsemblBacteria" id="ADT83416">
        <property type="protein sequence ID" value="ADT83416"/>
        <property type="gene ID" value="TERMP_00439"/>
    </dbReference>
    <dbReference type="GeneID" id="26135782"/>
    <dbReference type="KEGG" id="tba:TERMP_00439"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.439"/>
    <dbReference type="eggNOG" id="arCOG02208">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_2_0_2"/>
    <dbReference type="OMA" id="VASKFVH"/>
    <dbReference type="OrthoDB" id="67224at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13595">
        <property type="entry name" value="PBP2_HisGs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01018">
        <property type="entry name" value="HisG_Short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024893">
        <property type="entry name" value="ATP_PRibTrfase_HisG_short"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="14">
        <location>
            <begin position="46"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADT83416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="205" mass="22945" checksum="27E788455568F868" modified="2011-05-03" version="1">MRFVLPKGRLFKGSLEILQKAGIELKPPENRELIVKNGRYELLLARAFDVPVYVEYGVDVGIAGSDVVEERESDVLVPLELPFGKCRLSLAMPKENVVSVEEMDGFRIATKYPNLARKFFEKRGVEVEVIKLHGSIELAPKIGIADAIVDIVETGNTLRANGLVEVEKIMDVSALLLVNRISQKTKFKEINELVLKIKEVIKDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJF3</accession>
    <name>F0LJF3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-glycosylase/DNA lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">8-oxoguanine DNA glycosylase</fullName>
            <ecNumber evidence="2">3.2.2.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">AGOG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="2">AP lyase</shortName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="2">Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="2"/>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466717.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00442"/>
    <dbReference type="EnsemblBacteria" id="ADT83419">
        <property type="protein sequence ID" value="ADT83419"/>
        <property type="gene ID" value="TERMP_00442"/>
    </dbReference>
    <dbReference type="GeneID" id="10040760"/>
    <dbReference type="KEGG" id="tba:TERMP_00442"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.442"/>
    <dbReference type="eggNOG" id="arCOG04144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085935_0_0_2"/>
    <dbReference type="OMA" id="VKMFGYA"/>
    <dbReference type="OrthoDB" id="108705at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000702">
        <property type="term" value="F:oxidized base lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01168">
        <property type="entry name" value="AGOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016544">
        <property type="entry name" value="AGOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015254">
        <property type="entry name" value="AGOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09171">
        <property type="entry name" value="AGOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008955">
        <property type="entry name" value="AGOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1 2" id="KW-0228">DNA excision</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>8-oxoguanine</name>
            <dbReference type="ChEBI" id="CHEBI:52617"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>8-oxoguanine</name>
            <dbReference type="ChEBI" id="CHEBI:52617"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>8-oxoguanine</name>
            <dbReference type="ChEBI" id="CHEBI:52617"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>8-oxoguanine</name>
            <dbReference type="ChEBI" id="CHEBI:52617"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>8-oxoguanine</name>
            <dbReference type="ChEBI" id="CHEBI:52617"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>8-oxoguanine</name>
            <dbReference type="ChEBI" id="CHEBI:52617"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>8-oxoguanine</name>
            <dbReference type="ChEBI" id="CHEBI:52617"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="264" mass="30926" checksum="1913E0873C44302C" modified="2011-05-03" version="1">MTLDRFITVKYKENKPKIERLKGILRELGIECARTIEEKVDLQFSALEHLYKNLKNDELFIKLVIANAVVSYQLTATGEEWWWEFAEYFSSNPSEKGIADAYSRFLSESKTNRRLTAAKIKRLEKLEPFLAELKLKDLKNYYYSMTSLRNDLAKVLNSKRNAKTIVFAVKMFGYAGRIAFREFIPYPMEIEIPDDVRINAYTKRFTNEPPTVFWSRIARDVDIPPLHIDSILWPVLGKHAEVKERLKKYCPRAELIFELASLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJG3</accession>
    <name>F0LJG3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclic 2,3-diphosphoglycerate synthetase</fullName>
            <shortName evidence="5">cDPGS</shortName>
            <ecNumber evidence="5">6.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cpgS</name>
        <name evidence="6" type="ordered locus">TERMP_00452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(2R)-2,3-bisphosphoglycerate + ATP + H(+) = ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="ChEBI" id="CHEBI:79081"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.5.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.9" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466727.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00452"/>
    <dbReference type="EnsemblBacteria" id="ADT83429">
        <property type="protein sequence ID" value="ADT83429"/>
        <property type="gene ID" value="TERMP_00452"/>
    </dbReference>
    <dbReference type="GeneID" id="10040770"/>
    <dbReference type="KEGG" id="tba:TERMP_00452"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.452"/>
    <dbReference type="eggNOG" id="arCOG01230">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_638764_0_0_2"/>
    <dbReference type="OMA" id="RRCGGGM"/>
    <dbReference type="OrthoDB" id="18931at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036356">
        <property type="term" value="F:cyclic 2,3-diphosphoglycerate synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01908">
        <property type="entry name" value="Cyc_PG_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016557">
        <property type="entry name" value="Cyc_diphosphoglycerate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009445">
        <property type="entry name" value="Cyc_PG_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="433" mass="47827" checksum="67B5DADF4BF9605B" modified="2011-05-03" version="1">MRLVLIDGEHYPDVIRWAIKKIGNVCCAVFLGGSEKIGKLEDLERVIGIPLYHDADYLKALERAIIENPVREVVDLSDEPILNYEDRFRIASLLMKYGITYRGADFEFKPKKMRGIKKPSLAVIGTGKRVGKTAVSGFVARTLKEVAKPIIVTMGRGGPETPEIIYGDKFEITPEFLLKMAEKGKHAASDHFEDALTARVTTVGCRRCGGGMAGFSFFDIVEEGIKIAEKLEGDVIILEGSGATFPAFRADKYITVVGATQKLSFIKGYFGPFRVGLADLVVVTMADMVSKRKINAVEKAIERINPDADVHLTAFRPKLLGKAEGRAVLIMTAPRKAVKRAANYIEEQYGIEIVGISPNLANRSKLRNDLKTFRNYDTVLVELKAAAVDVVTREALKGGKKIVYLDNEPVNVDGKNLREAVLKLGKELLEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJG5</accession>
    <name>F0LJG5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <shortName evidence="8">GAPDH</shortName>
            <ecNumber evidence="8 10">1.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gap</name>
        <name evidence="12" type="ordered locus">TERMP_00454</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8 10">
            <text>D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8 10">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.59" evidence="8 10"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466729.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00454"/>
    <dbReference type="EnsemblBacteria" id="ADT83431">
        <property type="protein sequence ID" value="ADT83431"/>
        <property type="gene ID" value="TERMP_00454"/>
    </dbReference>
    <dbReference type="GeneID" id="10040772"/>
    <dbReference type="KEGG" id="tba:TERMP_00454"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.454"/>
    <dbReference type="eggNOG" id="arCOG00493">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069533_0_0_2"/>
    <dbReference type="OMA" id="NAIVPNP"/>
    <dbReference type="OrthoDB" id="32079at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047100">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00559">
        <property type="entry name" value="G3P_dehdrog_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006436">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01546">
        <property type="entry name" value="GAPDH-II_archae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="8">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="8">
        <location>
            <begin position="192"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT83431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="334" mass="37285" checksum="A730F53586944197" modified="2011-05-03" version="1">MKVKVGINGYGTIGKRVAYAITKQDDMALIGVTKTKPDFEAYRAKELGIPVYAASEEFLPRFEKAGFEVAGTLEDLLQKVDVIVDATPGGMGAKNKPIYEKYGVKAVFQGGEKADVAEVSFVAQANYEKALGKSYVRVVSCNTTGLTRTLSAIQEYIDYVYAVMIRRAADPNDIKRGPINAIKPTVEVPSHHGPDVQTVIPINIETTAFVVPTTIMHVHSIMVELKKPITKKDVIDIFENTTRVLLFEKEKGFDSTAQLIEFARDLHREWNNLYEIAVWKESINVKGNRLFYIQAVHQESDVVPENIDAIRAMFELADKWESIKKTNNSLGILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJH4</accession>
    <name>F0LJH4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466738.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00463"/>
    <dbReference type="EnsemblBacteria" id="ADT83440">
        <property type="protein sequence ID" value="ADT83440"/>
        <property type="gene ID" value="TERMP_00463"/>
    </dbReference>
    <dbReference type="GeneID" id="26136021"/>
    <dbReference type="KEGG" id="tba:TERMP_00463"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.463"/>
    <dbReference type="eggNOG" id="arCOG03817">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2613809_0_0_2"/>
    <dbReference type="OrthoDB" id="131085at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="78" mass="9064" checksum="77BBDB0E5D029DA5" modified="2011-05-03" version="1">MKSYEKREATNEVQLELLELTKQMSSLNYKLYEVYTANRALAIKILGYSSENIALGGKGMSREVEKIIDYYLRPGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJI8</accession>
    <name>F0LJI8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="2 9">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_00477</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="2 9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466752.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00477"/>
    <dbReference type="EnsemblBacteria" id="ADT83454">
        <property type="protein sequence ID" value="ADT83454"/>
        <property type="gene ID" value="TERMP_00477"/>
    </dbReference>
    <dbReference type="GeneID" id="10040795"/>
    <dbReference type="KEGG" id="tba:TERMP_00477"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.477"/>
    <dbReference type="eggNOG" id="arCOG00794">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133784_0_0_2"/>
    <dbReference type="OMA" id="ICKTKLW"/>
    <dbReference type="OrthoDB" id="115986at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="9 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="10">
        <location>
            <begin position="14"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="170" mass="19886" checksum="FB1CF69A8614826D" modified="2011-05-03" version="1">MTDTYPETHLIIRGTEINYLFICPTKLWYFAKGITMEQESEYVDLGKFLHEKSYFGEEKDVKIGMISIDFIKKGDIIEVHEVKKGKSMEKAHEMQALYYLYYLKKLGINAKAILNYPKLRETKEITLEGREKEVEKAIGEVEQIKSLSVPPKPVKTKKCKKCAYYELCWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJK7</accession>
    <name>F0LJK7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467947.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01674"/>
    <dbReference type="EnsemblBacteria" id="ADT84649">
        <property type="protein sequence ID" value="ADT84649"/>
        <property type="gene ID" value="TERMP_01674"/>
    </dbReference>
    <dbReference type="GeneID" id="10041990"/>
    <dbReference type="KEGG" id="tba:TERMP_01674"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1673"/>
    <dbReference type="eggNOG" id="arCOG00271">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_15_1_2"/>
    <dbReference type="OMA" id="VFIWGFT"/>
    <dbReference type="OrthoDB" id="47457at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="153"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="286" mass="31798" checksum="50D2AE9E15FD9D1A" modified="2011-05-03" version="1">MEISGRIKITVSMLIWGSVGIFARFTNLNGLGIAFFRVALGALILALLFSIKDKSWFQKVSGATKQKFGWMILLGIALALNWVFLFTAFLYTSIARAVLIYYSAPVLATLISAKFLKEKISKFQILLILMAFLGLMIIMSEQKMNFKNRDFVGAVFAFIAAVFYAMIPNLGRFLKEVKSDILTFVQLFIASVILIPFVLYGKIFAGKINWFAVGILVAVHTVFALFLYMDGLKNVKVNEVALLSYLDPLSAVVYAFLVFGEVPALRTVIGGVLILSASLLDTLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJL8</accession>
    <name>F0LJL8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01685"/>
    <dbReference type="EnsemblBacteria" id="ADT84660">
        <property type="protein sequence ID" value="ADT84660"/>
        <property type="gene ID" value="TERMP_01685"/>
    </dbReference>
    <dbReference type="GeneID" id="26137116"/>
    <dbReference type="KEGG" id="tba:TERMP_01685"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1684"/>
    <dbReference type="eggNOG" id="arCOG00749">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_10_0_2"/>
    <dbReference type="OMA" id="IKEQTYV"/>
    <dbReference type="OrthoDB" id="34606at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="273"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="480" mass="53426" checksum="359E47E83C290207" modified="2011-05-03" version="1">MRWVDVKESIKDFWFEFRRQKGGLLGLFLLALLVFTAIAAPYITEPDIPKKWTTYWEGNPTNVPPVWYNYFTAKKLAAHEVLTYNDLKVTAEGQDLGGGIKYYAFEFDYNNRYDLPPKDLIIKNIGVQLADLNTPAQIVITVYRPDGKKIELLSADLVEGSIYQIAKMGAVRNNVFNWASQFEDPKNLQGRVETIKSTMDVMEVIFAKAEPGILINPQPLHGDYKFQVEIFTFNKGDKVDLKPIQIILTGRTYGLMGTDYKGRDLWAGLVWGTRVSLVVGVSVAVLSVLIGIAYGVTSAYLGGWKDEFMQRVNEFVASIPTLPILILLGAAFKGHVTLWTIVFLLVMFGWTGIAKVARSMALQIKEQTYVEAAKALGAGTGRIIFKHIMPQIMPYAFAVMALSVPGAVLTEASLSFLGLGDPTAVTWGQILYDAQTNSATINGYWWWVIPPGLAISLVALTFVLIGVALDRVLNPRLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJM9</accession>
    <name>F0LJM9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">V-type ATP synthase alpha chain</fullName>
            <ecNumber evidence="4 13">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">V-ATPase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpA</name>
        <name evidence="15" type="ordered locus">TERMP_01696</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="4 13"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467969.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01696"/>
    <dbReference type="EnsemblBacteria" id="ADT84671">
        <property type="protein sequence ID" value="ADT84671"/>
        <property type="gene ID" value="TERMP_01696"/>
    </dbReference>
    <dbReference type="GeneID" id="10042012"/>
    <dbReference type="KEGG" id="tba:TERMP_01696"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1695"/>
    <dbReference type="eggNOG" id="arCOG00868">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008162_3_1_2"/>
    <dbReference type="OMA" id="RIVKTFW"/>
    <dbReference type="OrthoDB" id="6736at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005726">
        <property type="entry name" value="ATP_synth_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01043">
        <property type="entry name" value="ATP_syn_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="14">
        <location>
            <begin position="223"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="231"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADT84671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="585" mass="65490" checksum="F52A33715C7CBFD8" modified="2011-05-03" version="1">MGKVIRVTGPLVVADNMRGARMYEVVKVGELGLIGEIIRLEGDKAVIQVYEETAGLKPGEPVIGTGASLSVELGPGLLTSIYDGIQRPLEVLREKSGDFIARGLTAPALPRDKKWHFTPKVKVGDKVVSGDIIGEVPETSLIVHKIMIPPGIEGEIVEIAEEGEYTIEEVVAKVKTPGGEIKELKMYQKWPVRKKRPYKEKLPPHVPLITGQRTIDTFFPQAKGGTAAIPGPFGSGKTVTQHQLAKWSDAQVVVYIGCGERGNEMTDVLEEFPKLKDPRSGKPLMERTVLIANTSNMPVAAREASIYTGITIAEYFRDMGYDVALMADSTSRWAEALREISGRLEEMPGEEGYPAYLASKIAEFYERAGRVVTLGSDYRVGSVSVIGAVSPPGGDFSEPVVQNTLRVVKVFWALDADLARRRHFPAINWLMSYSLYVDAVKDWWHQNIDPEWKEMRDTAMKLLQKEAELQEIVRIVGPDALPDRERAVLLVTRMIREDYLQQDAFHEVDTYCPPKKQVTMMRVLLNFYNYTMQAIDRGIPVEEIAKLPVREKIGRMKFEPNIDEIAKLIDETKEQFEELFKKYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJP8</accession>
    <name>F0LJP8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="11">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">alaS</name>
        <name evidence="13" type="ordered locus">TERMP_01715</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="11"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467988.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01715"/>
    <dbReference type="EnsemblBacteria" id="ADT84690">
        <property type="protein sequence ID" value="ADT84690"/>
        <property type="gene ID" value="TERMP_01715"/>
    </dbReference>
    <dbReference type="GeneID" id="10042031"/>
    <dbReference type="KEGG" id="tba:TERMP_01715"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1714"/>
    <dbReference type="eggNOG" id="arCOG01255">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_4_0_2"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="OrthoDB" id="7896at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_A">
        <property type="entry name" value="Ala_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022429">
        <property type="entry name" value="Ala-tRNA_lgiase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03683">
        <property type="entry name" value="A-tRNA_syn_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="12">
        <location>
            <begin position="57"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="607"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="711"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="715"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT84690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="911" mass="104331" checksum="BC67AE75C35C7ECA" modified="2011-05-03" version="1">MSMDMTTKMFKEEGWIRKTCKVCGKPFWTLDPDRETCGDPPCDEYQFIGKPGIPKKYTLEEMREAFLSFFERHGHGRVKRYPVLPRWRDDVLLVGASIMDFQPWVISGEADPPANPLTISQPSIRFTDIDNVGITGRHFTIFEMMAHHAFNYPGKPIYWMDETVELAFEFFTKDLKMKPEDITFKENPWAGGGNAGPAFEVLYRGLEVATLVFMQYKLAPPGTPDDQVVIIKGDRYVPMDTKVVDTGYGLERLVWMSQGTPTAYDAVLGYVVEPLKRMAGIEKIDDRILMENSRLAGMFDIEDMGDLKVLRREVAGRVGISVEELERLIRPYELIYAIADHTKALTFMLADGVVPSNVKAGYLARLLIRKSIRHLRELGLQIPLSEIVAMHIKALHKTFPEFKEMEDVILDIVNVEEKRYQETLKRGSDLVRREIKKLRKEGKDEIPLEKLILFYESHGLTPEIVKEIAEKEGIKVHIPDNFYSLVAKEAEKMAKEEKEEKIVDFELVRDLPDTRTLYYEDPFMKEFDAKVLKVIDDWVVLDKTAFYPEGGGQPYDTGELNGVEVLEVQKVGKVILHRVKDPGKFKEGMTVHGKIDWERRIQHMRHHTGTHVLMGALVRVLGKHVWQAGSQLSTEWARLDISHYKRISEEELKEIERLANRIVMEDRKVAWEWLPRTEAEQKYGFRLYQGGVVPGRIIRILNIEDWDVQACGGTHLPSTGLIGPIKILRTERIQDGVERIIFACGEAAIKEWQRERDIIKKTSEVFRVPPEKLPETAEKFFEEWKQARKEVEKLKKELAKLLVYELENKVEKIGEIEFIGEVVEGDLDHLREAALKLKKPKRVTALISEDTNAVVVAVGDEVPFKAGELIRIITSIAGGGGGGKKDLAQGKIKDVRKAREALEELRKRLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJS5</accession>
    <name>F0LJS5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamin ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468014.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01742"/>
    <dbReference type="EnsemblBacteria" id="ADT84717">
        <property type="protein sequence ID" value="ADT84717"/>
        <property type="gene ID" value="TERMP_01742"/>
    </dbReference>
    <dbReference type="GeneID" id="10042058"/>
    <dbReference type="KEGG" id="tba:TERMP_01742"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1741"/>
    <dbReference type="eggNOG" id="arCOG00226">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_6_1_2"/>
    <dbReference type="OMA" id="PTTNWMY"/>
    <dbReference type="OrthoDB" id="28853at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015888">
        <property type="term" value="P:thiamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13545">
        <property type="entry name" value="PBP2_TbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005948">
        <property type="entry name" value="ThiB-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01254">
        <property type="entry name" value="sfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="355" mass="40076" checksum="FCB08EAD1C8A53B9" modified="2011-05-03" version="1">MKNLALILALMVIVGGLGCISSNKEQTSKELVVYAYDSFVSWGLANATIPKFEKMYNVKVKIITVGDAGEVLNRLILEKDNPRADVVIGIDNNLIAKAIEAGVLEPYKPKNIDVVPKELIDALDPTYHVVPFDYGFIAVVYKKSEISNPPQSFDDLTKPEWKKSLIVEDPRTSSTGAAFLLWTIAVYGDPGWLYFWEKLKPNIYQITKGWDAGWEMWDKGEAPLFVSYATDPAYSAYESGKEPDIGAIIFKEGGYPQIEGIGLVKGAKHPDLAKKFIEFVLSEDFQKEIPLTNWMFPVNKNVQLPDVFKYAVKPDKLVSLDPKEIEQNYSRWLEEWTKLMIEGKTPEEIIKERKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJS7</accession>
    <name>F0LJS7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468016.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01744"/>
    <dbReference type="EnsemblBacteria" id="ADT84719">
        <property type="protein sequence ID" value="ADT84719"/>
        <property type="gene ID" value="TERMP_01744"/>
    </dbReference>
    <dbReference type="GeneID" id="10042060"/>
    <dbReference type="KEGG" id="tba:TERMP_01744"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1743"/>
    <dbReference type="eggNOG" id="arCOG02408">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100862_1_1_2"/>
    <dbReference type="OMA" id="TIAYVTR"/>
    <dbReference type="OrthoDB" id="88507at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002790">
        <property type="entry name" value="CHP00288"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00288">
        <property type="entry name" value="TIGR00288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="27"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="175" mass="19505" checksum="F54A851202200792" modified="2011-05-03" version="1">MKEKIFRILKREEREVKEKKEEPKKTIGLIIDGPNILRKEFGIRLEDIKEALERIGKIRVAKVVLNQYAPQGLIEAVVNQGFEPIIVAGDTDVRIAIEAMELIYNSDVDIIAIATRDADFLPIISEAKRKGKETIVIGVEPGFSVALQNAADYVIKMEGRGEGVGYGKNYKTHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJT0</accession>
    <name>F0LJT0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acylamino-acid-releasing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468019.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01747"/>
    <dbReference type="MEROPS" id="S09.071"/>
    <dbReference type="EnsemblBacteria" id="ADT84722">
        <property type="protein sequence ID" value="ADT84722"/>
        <property type="gene ID" value="TERMP_01747"/>
    </dbReference>
    <dbReference type="GeneID" id="10042063"/>
    <dbReference type="KEGG" id="tba:TERMP_01747"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1746"/>
    <dbReference type="eggNOG" id="arCOG01646">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_2_1_2"/>
    <dbReference type="OMA" id="DENHWIM"/>
    <dbReference type="OrthoDB" id="3754at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPPIV_N" evidence="4">
        <location>
            <begin position="157"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="425"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="635" mass="73513" checksum="04459C1C6B8C2D1C" modified="2011-05-03" version="1">MKKLDIRDLGKFKLVGGLDIHKNKTAFTVTEVNLEKDDYFSKIYLYDGRKVMQFTSGPKDSNPKFSPDGNFMAFTSKRNKESKESELYLIPTRGGEAKLLTRFKYGINDFEFSPDGKALAVISPVEVDRKKEKDDVHIIKEIPFWFNGIGWIYGKRAQIFLVNTESGRKRKLTKGKLNILTLKWSDDGSKIYFIAQEDRERKPMISDLYVLDVKSKKIEKLTDSKWRIGDFVIIDEKHFVLRMSTLERGIPTNTHIYLFNAETKEIKKLTEKLDRSAYNSLNCDVRGKSRNPLIYKDGWVYYIATDGPRANLFRVDLEGNIERVIAGDRSIETFGIGNYIAFIAQDAVTPTELYILRDGKEKRVTNFNEWIKEYKLSKPEHFKVKASDGVEIDAWIMRPVDFKEGKKYPTILEIHGGPKTAYGYSFMHEFHVLTSKGFVVIFSNPRGSDGYGEDFADIRKHYGERDYQDLMEVVDEALKRFDFIDPERIGVTGGSYGGFMTNWIVGHTNRFKAAVTQRSISNWMSFFGTTDIGYYFAPDQIGEDPWSNFEGYWEKSPLKYAPNVETPLLIIHSMEDYRCWLPEALQLFTALKYFGKTVELAVFPGENHDLSRSGKPKHRVKRLELIVGWFERWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJW2</accession>
    <name>F0LJW2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="9">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cysS</name>
        <name evidence="11" type="ordered locus">TERMP_00522</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466797.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00522"/>
    <dbReference type="EnsemblBacteria" id="ADT83499">
        <property type="protein sequence ID" value="ADT83499"/>
        <property type="gene ID" value="TERMP_00522"/>
    </dbReference>
    <dbReference type="GeneID" id="10040840"/>
    <dbReference type="KEGG" id="tba:TERMP_00522"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.522"/>
    <dbReference type="eggNOG" id="arCOG00486">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_2"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="OrthoDB" id="20883at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="10">
        <location>
            <begin position="354"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="474" mass="55851" checksum="6E12709B105D016E" modified="2011-05-03" version="1">MKVYNTLTKQKEEFKPLREGEVRMYVCGPTVYDYTHLGHARTYIAFDVIRRYLEHKGYTVLMVMNFTDIDDKIIRRAQETGEDPKELAEKFLKYFLEDMKALKVKPADIYPRVTEHIEDIIDFVKKLEEKGYAYEGSDGVYFEVQRFRDYGKLSGIKLEELRKGARVEPGEGKRNPEDFALWKKAKPGEPKWDSPWGEGRPGWHIECSTMSTKYLGEQFDIHGGGNDLIFPHHENEIAQTEACTGKEWVRYWLHTGFVMVKGEKMSKSLGNFVTIRELLQRYSPEVIRFFVLQKHYRSPLDYTEEGIQHAKNNLEKLYNTIENIRIALEKAEIPFKWSKEEFELYEVIREAKRKFYEAMDDDFNTAEAMKPIFEVANAVNKYLAKVEKPKESVLRKALEFFKMVGEVFGIFEEYFKETKETKEEELIELLIQVRAELRKQKNYALADKIRAELRELGIQLEDTPQGTIWKRINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJZ4</accession>
    <name>F0LJZ4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CobY-like adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466829.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00554"/>
    <dbReference type="EnsemblBacteria" id="ADT83531">
        <property type="protein sequence ID" value="ADT83531"/>
        <property type="gene ID" value="TERMP_00554"/>
    </dbReference>
    <dbReference type="GeneID" id="10040872"/>
    <dbReference type="KEGG" id="tba:TERMP_00554"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.555"/>
    <dbReference type="eggNOG" id="arCOG01871">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098907_0_0_2"/>
    <dbReference type="OMA" id="YAIVGLN"/>
    <dbReference type="OrthoDB" id="90478at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="185" mass="20426" checksum="E274D5293F20713F" modified="2011-05-03" version="1">MIIILAGGKSTRMGKEKPVLRIANKPMLLWIYEQAEKVDEVLVALSKNTPKTRELCLREGIPFIETSGKGYVHDIQELLKEFGPFISISADVPFVKASDFWLIRKAFDGKTSLTGVLPLSLVPNDLNPVVYRGCAIVGLNAVAGEGEEFFKLSNPLLALNVNTLEELELAEKIAKLIYSPKLSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK09</accession>
    <name>F0LK09_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466844.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00569"/>
    <dbReference type="EnsemblBacteria" id="ADT83546">
        <property type="protein sequence ID" value="ADT83546"/>
        <property type="gene ID" value="TERMP_00569"/>
    </dbReference>
    <dbReference type="GeneID" id="10040887"/>
    <dbReference type="KEGG" id="tba:TERMP_00569"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.570"/>
    <dbReference type="eggNOG" id="arCOG04318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099315_0_0_2"/>
    <dbReference type="OMA" id="EKTHGDI"/>
    <dbReference type="OrthoDB" id="100043at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="PTHR10741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741:SF2">
        <property type="entry name" value="PTHR10741:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="SSF74784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="205" mass="24126" checksum="990AD44CA6ACF2B6" modified="2011-05-03" version="1">MKIAEIITKIREVLDEKDALREEALKTTRDIVRLSGDAIKALHRGNFELAEKRLNKAQELVKHLKNMLKNHQDLYFTGYVQNAHQEFVEAMLFYSYLKDQDFPSPRELEIPEADYVLGIGDFIGELRRYFLILLMNGDIAKAEEVYHFMESVYEELMTLEYPKGLVNIRQKQDQARYILERTLEDLTRAKINKALEEKLEEALKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK41</accession>
    <name>F0LK41_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468049.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84753">
        <property type="protein sequence ID" value="ADT84753"/>
        <property type="gene ID" value="TERMP_01778"/>
    </dbReference>
    <dbReference type="GeneID" id="10042094"/>
    <dbReference type="KEGG" id="tba:TERMP_01778"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1777"/>
    <dbReference type="eggNOG" id="arCOG05794">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174526_0_0_2"/>
    <dbReference type="OMA" id="DRDLFLM"/>
    <dbReference type="OrthoDB" id="125505at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="104" mass="11824" checksum="2B30A368520B91DD" modified="2011-05-03" version="1">MKVEYRIGLILLIGLIASVILRSYAGILIAALGIPFYLAYTAREQNILAKSRLFDRDLFLMMGLTVLVILAFEYFADPRLGLIVMAIVIPLVIYWMDRLKTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK88</accession>
    <name>F0LK88_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPASM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468096.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01825"/>
    <dbReference type="EnsemblBacteria" id="ADT84800">
        <property type="protein sequence ID" value="ADT84800"/>
        <property type="gene ID" value="TERMP_01825"/>
    </dbReference>
    <dbReference type="GeneID" id="10042141"/>
    <dbReference type="KEGG" id="tba:TERMP_01825"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1824"/>
    <dbReference type="eggNOG" id="arCOG05729">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_902006_0_0_2"/>
    <dbReference type="OMA" id="CRALEYQ"/>
    <dbReference type="OrthoDB" id="56122at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPASM" evidence="1">
        <location>
            <begin position="225"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="310" mass="35732" checksum="888886F26BE0CF11" modified="2011-05-03" version="1">MERIASANISQPEIQRSWNIATIAKPPWANYSHSGKLERLILQLGQGKGKFSEITGIPRSIGCIGNNEFILRREPLSVERIKEIIREFYFANGRELYLTNYDSVEYLISVARHAAAIGIKEVYAVVRIKDIEKIIPEDDVRVIVELEYSKENLKKLKELKWVHGALIMIEPEQYAEFIKSKPEFDGEVYVDLLYPGSLRHLKFNVIEVKRVHSATANKYHDCLAGTLTITADGYALPCPLLRNFIVGDAKRETVKQLRRKKRLKNFWKLTKDGIEECKLCPFKYLCHDCRALEYQASGDIFGIEYCNLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK96</accession>
    <name>F0LK96_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulatory protein TERMP_00577</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00577"/>
    <dbReference type="EnsemblBacteria" id="ADT83554">
        <property type="protein sequence ID" value="ADT83554"/>
        <property type="gene ID" value="TERMP_00577"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00577"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.578"/>
    <dbReference type="eggNOG" id="arCOG04152">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075726_0_0_2"/>
    <dbReference type="OMA" id="PGVVYFR"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00584">
        <property type="entry name" value="HTH_type_cro_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020886">
        <property type="entry name" value="Arc_TR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="319" mass="36601" checksum="E240B14FFE2F33FB" modified="2011-05-03" version="1">MMEKERLIRVVESILRGTGFRTARMEFKGACFDLVASRLFLLLFIKVLQNIDTLTKEQAEDLKRLAKFFQASPLIVGLKTKNDELEEGVVYERFGIYALNPQTLYDVIVENELPAIFAERGGFYVKINGEYLRYLREKYGYSIGELAELLGVSRKSLQNYERGEQAVSLDVAIRLEEIFNEPLAKPIDILHAKVEAKLDVKPENELEREIFERLKALGMGVVKIKKAPFNAISKEEEFKILTGIDQRKTKTTIKRAQMINEVSKIIHSDGVFILEKTKTEVVGEIPLIPKKALSEIRDADELIEMIEELKKEIKKKIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKB7</accession>
    <name>F0LKB7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NOSY-like membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00598"/>
    <dbReference type="EnsemblBacteria" id="ADT83575">
        <property type="protein sequence ID" value="ADT83575"/>
        <property type="gene ID" value="TERMP_00598"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00598"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.599"/>
    <dbReference type="eggNOG" id="arCOG02436">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068384_1_0_2"/>
    <dbReference type="OMA" id="FMRREIR"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="315" mass="34977" checksum="CE7A4CCBB8B412BC" modified="2011-05-03" version="1">MDDEEGREEMNVFNIAMKEFYVSIKSKRFVIILLLYVIYLLLVAYALRNHLAELSKPTVGTTNLEPFGTRGEVFQTPLSMMLIANFSFFTIIGGIMGASLGADAINREIETGTIKTLLGHPVYRDEVINGKFLGNGLVLGITVMVGYLFTVAYLLIIGIPIDGESFFRGLIAFLVTLLYSLTFLSIAILISTMVRKPETSMLISIGLAIFLTLVYGIIVSLIAEHLAGEMPPYGPAFRVWRENVLLWEQRLHLINPAHHYAALVLAVFAGDRIANSYLPLSEVLALALNNLAMLVVFLMLPFALAYVRFMTSDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKC3</accession>
    <name>F0LKC3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor 1-alpha</fullName>
            <shortName evidence="6">EF-1-alpha</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Elongation factor Tu</fullName>
            <shortName evidence="6">EF-Tu</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tuf</name>
        <name evidence="8" type="ordered locus">TERMP_00604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466879.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00604"/>
    <dbReference type="EnsemblBacteria" id="ADT83581">
        <property type="protein sequence ID" value="ADT83581"/>
        <property type="gene ID" value="TERMP_00604"/>
    </dbReference>
    <dbReference type="GeneID" id="10040922"/>
    <dbReference type="KEGG" id="tba:TERMP_00604"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.605"/>
    <dbReference type="eggNOG" id="arCOG01561">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_2"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="OrthoDB" id="13117at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="5"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="89"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="428" mass="47551" checksum="91297A27730FFA8F" modified="2011-05-03" version="1">MAKEKPHVNIVFIGHVDHGKSTMIGRLLFDTANIPEQIIKKFEEMGEKGKSFKFAWVMDRLKEERERGITIDVAHTKFETPHRYITIIDAPGHRDFVKNMITGASQADAAVLVVAATDGVMPQTKEHAFLARTLGINHIIVCINKMDMVNYDEKRFKEVAAQVEKLLKMLGYKNFPIIPTSAWEGDNVVKKSDKMPWYKGPTLIEALDQIPEPPKPVDKPLRIPIQDVYSIKGVGTVPVGRVETGKLKVGDVVIFEPASTIFHKPIQGEVKSIEMHHEPLQEALPGDNIGFNVRGVSKNDIKRGDVAGHPDKAPTVVRPKDTFKAQIIVLNHPTAITVGYTPVLHAHTTQVAVRFEQLLAKLDPRTGNIVEQNPQFIKTGDSAIVILRPTKPMVIEPVKEIPQLGRFAIRDMGQTVAAGMVISIQKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKE5</accession>
    <name>F0LKE5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466901.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00626"/>
    <dbReference type="EnsemblBacteria" id="ADT83603">
        <property type="protein sequence ID" value="ADT83603"/>
        <property type="gene ID" value="TERMP_00626"/>
    </dbReference>
    <dbReference type="GeneID" id="10040944"/>
    <dbReference type="KEGG" id="tba:TERMP_00626"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.628"/>
    <dbReference type="eggNOG" id="arCOG00984">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_2"/>
    <dbReference type="OMA" id="IRFGPGC"/>
    <dbReference type="OrthoDB" id="22099at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08179">
        <property type="entry name" value="NADPH_BDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034802">
        <property type="entry name" value="NADPH_BDH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="8"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="378" mass="42222" checksum="76C8F32DF1D1EECE" modified="2011-05-03" version="1">MQFFSLKTRIVLGEGSLGYIKSIAKKHSRVLIFSSKSMRVHGFLNEAMNYVEDANAEVEAITGVPAEPSYEYVESIMPKVREFQPDLIVALGGGSVIDVAKAVKVFYDGTELKFEEVAFISRFEKPKPIPKLKTPLIAIPSTSGAGSEVSAASVLKKGDIKYNLVSFEIAPEFAILDPRLPRTMPKEVARNSGLDVLVHGIEAYTTTAATPFSDAMAIKAIKLVYKWLPLSVQGDEKARENVHYAATMAGIAFLNARLGLCHSLSHKAAWIAPHGLLNAIFLPYVMEFNMRSEYARKRYAEITRELGFNTAQELIEVIREFNEMLGVPKLSELVSEEEFLSKLDEMSEKAYHDPLINFNPVEPSIEEIKELYKRAFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKH8</accession>
    <name>F0LKH8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar abc transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468108.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01837"/>
    <dbReference type="EnsemblBacteria" id="ADT84812">
        <property type="protein sequence ID" value="ADT84812"/>
        <property type="gene ID" value="TERMP_01837"/>
    </dbReference>
    <dbReference type="GeneID" id="10042153"/>
    <dbReference type="KEGG" id="tba:TERMP_01837"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1836"/>
    <dbReference type="eggNOG" id="arCOG00159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_2"/>
    <dbReference type="OMA" id="AWLLKGY"/>
    <dbReference type="OrthoDB" id="57718at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="277" mass="30567" checksum="AE09D67F397F87B2" modified="2011-05-03" version="1">MNDKTRFMLKKLLLYSFLFTIVVWIVLPIIVSILYAFSSKLDYYDPQKVIPTHYTTQWVKTLLFTLGAWDGIKNSVIVAILTIIISFSLGIPAGYAIAKFIFPGKDTIKLSIIALRMFPIPVMAIPLVVLYIKLNLIDTLLGVALAHTAMALPFVVLITSSIFAGVSKELEEAAMVFGVTRLGAFFRITLPLALPGLAAAAMFTFVMSWNEVFVASILTLKNRTLPAQILSIMAGSSGGAAPPYYKFAAAFIMTLPAMIFIFFARKYLVSMWGITLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKJ6</accession>
    <name>F0LKJ6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1156 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468126.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01855"/>
    <dbReference type="REBASE" id="29888">
        <property type="entry name" value="M.TbaMPORF1855P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84830">
        <property type="protein sequence ID" value="ADT84830"/>
        <property type="gene ID" value="TERMP_01855"/>
    </dbReference>
    <dbReference type="GeneID" id="10042171"/>
    <dbReference type="KEGG" id="tba:TERMP_01855"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1854"/>
    <dbReference type="eggNOG" id="arCOG00889">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007795_2_0_2"/>
    <dbReference type="OMA" id="TVIAWIW"/>
    <dbReference type="OrthoDB" id="2122at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009537">
        <property type="entry name" value="DUF1156"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014455">
        <property type="entry name" value="N6_adenine_Mtase_MK1259"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06634">
        <property type="entry name" value="DUF1156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009427">
        <property type="entry name" value="UCP009427_DNAmts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1156" evidence="2">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1057" mass="120588" checksum="1986682842513A8D" modified="2011-05-03" version="1">MERTFLESPNFPIREINEKSAKEKGPARPPYWEMVFWWTRKPLIGARAVIAGALLPKDFDTNEFKKIIRLNEKTSPHRFNPQIPDKYKQYFEGKKLLDPFAGFGSIPLEGLRLGLDVTAVELLPTAYVFLKAVLEYPKKFGRLKVKVPVKELEALGLNSYAREAKKKIVANVEVPALVYDVAKWGNWITGQLKNDPELRELYDDDVAVYIGTWEVKCPHCGKWTPIVGNWWLARVKDSKGKYQRLAYMKPKRAKNGIEIEVVDLNRIVGDVSNARVDTRKGEIVFEDEEIVKELKPKIEKGEVDAKIRKIDGKEIVVFDVPKSNIESRRQQAFCLNCGNVMRFVDESGNHYTGKKGEGEFYIKFALKKYHQGDESYARQRLLVKVKIEDKDLVFEPATKEDNAKLEKAKEKVKELLEKGNPDIPREPVPPYGSLLFGALQIIGWGFDQWYKLFNPRQLLTLIKILRLIREVGRKVEEEKLKEGWGEEKAFEYAEAVATYLAIALGRYADYNSINTLWNAGSWSDNKVAHTLSSRGIAMQWNWCEIPAVKDLPLTYSGNLPNLKNAIGYLTSALSSGQRTLTGLSSNTVKVIQGDATSLNLPEKFDVIVTDPPYSIDVPYAELSDFYYVWLKRALSDVEGNKLVPRFHSEAFFKKIGKKYREREVQWKEFASKEVSEFSARFFTEREKEKLAKEHFKNLFTQAFIAMKTNLKDDGILATYYAHTSLDAWATLIEAGWQGAKLQITTAIPLSTESATSIMSRGKLSLDTSIIAVWRKVKRDGKKVVDVRDFVEYKDPYTGEVKKVRFTEKIQLVAEEKARQLLAHGYTGLDLLYGVIASALSVITEYEEVQRYGTKLPVLEILEKYVYPASAQAIAKALAQEVHGRVSSKEALFYLLAKLLFGKAKVSSNDVVLLSIATETNSRELISSKILLEKKEGSSKYYQLNSPQSDNLTKLEAFLKSRGIDIANPKPKNAIDALHLLEYYAKRHPKSEFRRRYDELKQKYQSLVEEATNLALIFTSMAKNLRWDDVEFKLAENIAEKLELIKKPQKTLMEIIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKM4</accession>
    <name>F0LKM4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="16">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="16">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="16">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">nnrE</name>
        <name evidence="14" type="synonym">nnrD</name>
        <name evidence="18" type="ordered locus">TERMP_01883</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15 16">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14 16">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14 16">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="15 16">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="16"/>
    <dbReference type="EC" id="5.1.99.6" evidence="16"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468154.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01883"/>
    <dbReference type="EnsemblBacteria" id="ADT84858">
        <property type="protein sequence ID" value="ADT84858"/>
        <property type="gene ID" value="TERMP_01883"/>
    </dbReference>
    <dbReference type="GeneID" id="10042199"/>
    <dbReference type="KEGG" id="tba:TERMP_01883"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1882"/>
    <dbReference type="eggNOG" id="arCOG00018">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_4_1_2"/>
    <dbReference type="OMA" id="HNGGDAL"/>
    <dbReference type="OrthoDB" id="41305at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
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        <property type="entry name" value="CARKD"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11 15 16" id="KW-0413">Isomerase</keyword>
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    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="7 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="17">
        <location>
            <begin position="6"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="53"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="128"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
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        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
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        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
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            <position position="304"/>
        </location>
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        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
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        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
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        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
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        </source>
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            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ADT84858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="480" mass="52518" checksum="1A8EBD622474DF4A" modified="2011-05-03" version="1">MKIEDVYIWDTNAKWLGISPFQLMENAGAGVARAIEEKFGRGLKVAIFCGTGNNGGDGFVAARHLSFENDVTVFLVGDEIKIRSEEAKHNWEILKKLDFVKIKILKDSSQIKGLNLEEYDVIVDALLGAGTKGEPREPIRSAIKKINEYSGKAKIVSVDLPSGYPSKVQVKCDFAVTFQWDKEEFEGFERIVAKIGYPKELYHLVGPGNAKFALRKKGEHKGQNGRLLIIGGSEDYFGAPYLAAKAASYIVDLVYLVMPEYSAKRITDPDMILRPVEGKNFTREHLEEVLALTEKADAVIVGPGIGLRDETREFVREFVKRCEKPLVIDADGLKAIAEDLSVLNGKTFVLTPHAGEFKTLFGEKPEGSLKEKAGLVMKKAKEINGVILLKGVYDIISDGKVWKYNKTGNRGMTTGGTGDVLAGIIGALLALGNSPLRAASVGAFLNGLAGDTVKEELGENFTALNVAKKVPHAVKWVLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKM5</accession>
    <name>F0LKM5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468155.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01884"/>
    <dbReference type="EnsemblBacteria" id="ADT84859">
        <property type="protein sequence ID" value="ADT84859"/>
        <property type="gene ID" value="TERMP_01884"/>
    </dbReference>
    <dbReference type="GeneID" id="10042200"/>
    <dbReference type="KEGG" id="tba:TERMP_01884"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1883"/>
    <dbReference type="eggNOG" id="arCOG01683">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121767_0_0_2"/>
    <dbReference type="OrthoDB" id="105440at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
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    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="185" mass="21887" checksum="B034FDCC8471690B" modified="2011-05-03" version="1">MREVLIITEIERMKVLAEPTRFKILELLRRHPMSIAELSSFLKKDRSTVYRHIKVLENAGFVEEIGQEGNERIYARTARLFLLKVEPDESIEEFRKQYLRIEASRLMEILKKSGIKIKNENEFLRLTAQILKEIEDNSRPIIQKVSQADLDLKEIELFHLLNLLVFLQSCEFCEKAKKMKNLLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKN3</accession>
    <name>F0LKN3_THEBM</name>
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        <submittedName>
            <fullName evidence="5">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468163.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01892"/>
    <dbReference type="EnsemblBacteria" id="ADT84867">
        <property type="protein sequence ID" value="ADT84867"/>
        <property type="gene ID" value="TERMP_01892"/>
    </dbReference>
    <dbReference type="GeneID" id="10042208"/>
    <dbReference type="KEGG" id="tba:TERMP_01892"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1891"/>
    <dbReference type="eggNOG" id="arCOG00175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="PEVMFFD"/>
    <dbReference type="OrthoDB" id="87718at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="239" mass="27013" checksum="77A7190AF79AF2A2" modified="2011-05-03" version="1">MIVRAENLVKSYEDHRALDGVSLEVKKGEIFCVMGHSGAGKTTLLRILALLERPDSGEYFFDGKPVNWSRPGELRKNITMVFQTPVMFNTTVFKNIAYGLKLRGYSRAEIEKKVHEVLSLVRLEGYEKRKAKTLSGGEKQRVAIARAIVLEPKLLLMDEPTANLDPTNSAIIEDIVKEITKENGTTIVFSTHNMFQAKRLADRVAHMYAGKIVEVGKTKEVFERPKSELTKRFINGELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKR2</accession>
    <name>F0LKR2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inosine-5'-monophosphate dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00664"/>
    <dbReference type="EnsemblBacteria" id="ADT83641">
        <property type="protein sequence ID" value="ADT83641"/>
        <property type="gene ID" value="TERMP_00664"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00664"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.666"/>
    <dbReference type="eggNOG" id="arCOG00622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1912450_0_0_2"/>
    <dbReference type="OMA" id="VLIPTQW"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="39"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="139" mass="16507" checksum="A606DAD3AB8F2435" modified="2011-05-03" version="1">MTEKKEILLITREKAFERARHLKRENELIYGVKFIIDHKYLPLDILIPTQRELSEAKLLIVLQEIKHGYDAPIIVLEHQKKYYILDGHHRAYALKKLGFSQVECLILKPKKEIKTKIEETVQRSKLKSLDDIKIVRNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKW0</accession>
    <name>F0LKW0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83689">
        <property type="protein sequence ID" value="ADT83689"/>
        <property type="gene ID" value="TERMP_00712"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00712"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.714"/>
    <dbReference type="eggNOG" id="arCOG05088">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_668385_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="411" mass="47284" checksum="0482345667CC7855" modified="2011-05-03" version="1">MLKKVFKAQNLPKMSEKERMQYFEKVYLRNSKPLNVTQKKANIILEVYRYGIYVHPLTLKKYLRIDTKIKNLGNNSVELMIREPAKLTVDGFSVIEYPKDISSIKSKKLEPGKDITEEFLFPMEEISLEGREFILEVHETEMLPEREAEIMLPKLKFSLNYTLVNISKPAEKFPIEITLMKYAVFEYETPEGKEEGVKVLLKIKNTGDNEVKIDLNGITLGGEVKIAPFTWFLTVGPHSEKQTWLLFPYVQGKTTLTVHLYDLTELKDELIEIPFEIKGTPRTREIKVNKTIEEYPLKITIEKVEEIPYLEITKLKSLVKIYLTLENTGETALPLNIEQWGLLTSKGVLIPGDVVMSNLTNVIELTPGNCVSGYVVFKDIPEDAQYILKIKIPNALRTIEFKVKLPIRLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL67</accession>
    <name>F0LL67_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467016.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00741"/>
    <dbReference type="EnsemblBacteria" id="ADT83718">
        <property type="protein sequence ID" value="ADT83718"/>
        <property type="gene ID" value="TERMP_00741"/>
    </dbReference>
    <dbReference type="GeneID" id="10041059"/>
    <dbReference type="KEGG" id="tba:TERMP_00741"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.743"/>
    <dbReference type="eggNOG" id="arCOG04756">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_971885_0_0_2"/>
    <dbReference type="OMA" id="GWWSIPL"/>
    <dbReference type="OrthoDB" id="64716at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="286" mass="31601" checksum="9DF37A72C75D8277" modified="2011-05-03" version="1">MKVPEMLILIAFGHLIGRKFNLAKVGRFASKYLLAFLIFGNIASKSLDYLLSIKIVFIYAVLVIVICLLSSYLYGYAFIKDHKWRGALIVLSVYPNLSALGFPIVSLFVNDITPAVIYASITSMTVVPIVTFVASHFSDHASTLKESLRTSLFFPPSIATVLGVTAVVLNIKIPCLNVIKRIGWLTIPLLLIYFGSRITLKRFTLKSFAEVLVFRSLIPAVFVVTTLYGYSEEVFYSVLVESVMPPAISANAILAYYNLKAEDAISATFAHTILTLAVFIVLGILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL80</accession>
    <name>F0LL80_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4392 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00754"/>
    <dbReference type="EnsemblBacteria" id="ADT83731">
        <property type="protein sequence ID" value="ADT83731"/>
        <property type="gene ID" value="TERMP_00754"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00754"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.756"/>
    <dbReference type="eggNOG" id="arCOG05870">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062537_1_0_2"/>
    <dbReference type="OMA" id="DVSNWGA"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025504">
        <property type="entry name" value="DUF4392"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14336">
        <property type="entry name" value="DUF4392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4392" evidence="1">
        <location>
            <begin position="5"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="271" mass="29882" checksum="44ADB990CE71D6AA" modified="2011-05-03" version="1">MKMIAHIINTDIYGRGILKVYLEYRLRNFNFLKNAAKLLIDNSEKVLVVSSFPIPPMNICENDGPLGALALYKTVEKIGGKAEIWAHEQVKKALKPFDITFVEQPDVSEYSLLISVETVGRAKDGKYYSMSGFEVKTTTPFDEIFLEAKKLGIPTIGIGDGGNEIGMGKIRHLIEKYIPLGGKIASIVDTDELIVSAVSNWGAYGLVAQVSLEVGENLLEGWDERKNLQVIVSAGLIDGIIKKPAMSVDGISVDIHEKIVELLKETVNYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLB3</accession>
    <name>F0LLB3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467062.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00787"/>
    <dbReference type="EnsemblBacteria" id="ADT83764">
        <property type="protein sequence ID" value="ADT83764"/>
        <property type="gene ID" value="TERMP_00787"/>
    </dbReference>
    <dbReference type="GeneID" id="10041105"/>
    <dbReference type="KEGG" id="tba:TERMP_00787"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.789"/>
    <dbReference type="eggNOG" id="arCOG07800">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1700351_0_0_2"/>
    <dbReference type="OMA" id="TECPCEN"/>
    <dbReference type="OrthoDB" id="114482at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="154" mass="16697" checksum="61EA3DFD3DC24F32" modified="2011-05-03" version="1">MRKKILGVGLLALVVGLVFGAAAAYQGAPSETANTTECPCENFVKARYMHGQNGEHGKGTPQFMGLGIKGQYLGEANVDEQQIQEYLSGVTIEGFTTPRGITVQKLVLDGEYIGKIVGDYDLSSLEVYKAYETQNGIKVFLSYDGNIVGFFLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLE4</accession>
    <name>F0LLE4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anaerobic ribonucleoside-triphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84973.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|391623.17.peg.1996"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="95067at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="126" mass="14815" checksum="490BEE13325F4684" modified="2011-05-03" version="1">MIFENIFKENLERNELWLIITFKTPYGPGETMDLMVKELEKLGWEIKFKANWWTADVPYGLIRIDAVHNGKEKIILGKWILGDKCRVIKVDNAGIEAGKEEFFRMVDSITSTLIYDPVIRTMREQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLG3</accession>
    <name>F0LLG3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02018</name>
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    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
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            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT84992">
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        <property type="gene ID" value="TERMP_02018"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02018"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2015"/>
    <dbReference type="eggNOG" id="arCOG11330">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208228_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="43" mass="5287" checksum="5FB782ABFD33A673" modified="2011-05-03" version="1">MKPTLIIKTREKEFEVELFEEDYEHESKPKVKFIQEVKRIHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLL4</accession>
    <name>F0LLL4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467089.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00814"/>
    <dbReference type="EnsemblBacteria" id="ADT83791">
        <property type="protein sequence ID" value="ADT83791"/>
        <property type="gene ID" value="TERMP_00814"/>
    </dbReference>
    <dbReference type="GeneID" id="10041132"/>
    <dbReference type="KEGG" id="tba:TERMP_00814"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.816"/>
    <dbReference type="eggNOG" id="arCOG04171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135994_0_0_2"/>
    <dbReference type="OMA" id="AEHASTF"/>
    <dbReference type="OrthoDB" id="112766at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007171">
        <property type="entry name" value="DUF371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023131">
        <property type="entry name" value="Mth639-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40696">
        <property type="entry name" value="PTHR40696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04027">
        <property type="entry name" value="DUF371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="144" mass="16488" checksum="0129A32F0F6F7EBD" modified="2011-05-03" version="1">MTREVIHCYGHENIKATHKSTLEITKEDFLTPRGDCIICIKADKSLRDLSDEFKQALKSGKKIRIRIIVDDLVDEIFASGDERLTFENDVSMVIRKSTYIDGRTLAVKANKAAKDIDRRIIEKLKNPNQKAVIELIVYDDPAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLP0</accession>
    <name>F0LLP0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0033 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467115.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00840"/>
    <dbReference type="EnsemblBacteria" id="ADT83817">
        <property type="protein sequence ID" value="ADT83817"/>
        <property type="gene ID" value="TERMP_00840"/>
    </dbReference>
    <dbReference type="GeneID" id="26136289"/>
    <dbReference type="KEGG" id="tba:TERMP_00840"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.843"/>
    <dbReference type="eggNOG" id="arCOG02062">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165255_0_1_2"/>
    <dbReference type="OMA" id="EIPMACE"/>
    <dbReference type="OrthoDB" id="124510at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="1">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="73" mass="8180" checksum="1B81CA36CF0F0349" modified="2011-05-03" version="1">MIKINVIGKECPIPLNEFRKALRKAKVGEVIEIVGTHELSKGEIALAADETGQEILEIDEKDGIWRIVVKKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLW1</accession>
    <name>F0LLW1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468356.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02086"/>
    <dbReference type="EnsemblBacteria" id="ADT85060">
        <property type="protein sequence ID" value="ADT85060"/>
        <property type="gene ID" value="TERMP_02086"/>
    </dbReference>
    <dbReference type="GeneID" id="10042401"/>
    <dbReference type="KEGG" id="tba:TERMP_02086"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2083"/>
    <dbReference type="eggNOG" id="arCOG00726">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121774_2_1_2"/>
    <dbReference type="OMA" id="SNAIWKH"/>
    <dbReference type="OrthoDB" id="116013at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="126" mass="14420" checksum="E6C0D49BEB041DB2" modified="2011-05-03" version="1">MIVIDASSLAKYILREENWKTEVSNAIWKHHVLYKAISNKEVGIMLEVLKKLKEDVVIFEPFEDYLGDAVKIAIGGKISIYDALYLAQAKKYGSLLISDEKQWKIAKKLGIKAEYVEQRYLVVEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM81</accession>
    <name>F0LM81_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRISPR-associated endoribonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467226.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00952"/>
    <dbReference type="EnsemblBacteria" id="ADT83928">
        <property type="protein sequence ID" value="ADT83928"/>
        <property type="gene ID" value="TERMP_00952"/>
    </dbReference>
    <dbReference type="GeneID" id="10041269"/>
    <dbReference type="KEGG" id="tba:TERMP_00952"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.955"/>
    <dbReference type="eggNOG" id="arCOG04342">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089858_1_1_2"/>
    <dbReference type="OMA" id="HWDLYPH"/>
    <dbReference type="OrthoDB" id="59332at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010156">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045747">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36984">
        <property type="entry name" value="PTHR36984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01881">
        <property type="entry name" value="Cas_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005054">
        <property type="entry name" value="PF1131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01877">
        <property type="entry name" value="cas_cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="249" mass="29354" checksum="E324CF25F708A0E4" modified="2011-05-03" version="1">MRIEIRLKPRDEGTILPFNYNYDVYTQIIQKVAINSPELARLLETTHKDYFTFSRIMVRKRELIPDKGIKILSDEVCLYISSSVVDVIKSIVEGFIENPVLQIENSTFIMDGVKVLREPKIKDGTLFSTLSPIIVRTVKLEGNRMKIWDLYPSEETFHDKLRKIMLMRFSEIEERMPEDKDFRIDVIKYKPVRIKVKDTYFRGSLMVFRYYGSKEIAKFAYENGFGEKTKYGFGMVKVIDEEEAQRSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMA5</accession>
    <name>F0LMA5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468424.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02154"/>
    <dbReference type="EnsemblBacteria" id="ADT85128">
        <property type="protein sequence ID" value="ADT85128"/>
        <property type="gene ID" value="TERMP_02154"/>
    </dbReference>
    <dbReference type="GeneID" id="10042469"/>
    <dbReference type="KEGG" id="tba:TERMP_02154"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2150"/>
    <dbReference type="eggNOG" id="arCOG03169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061108_0_0_2"/>
    <dbReference type="OMA" id="GYNRWSL"/>
    <dbReference type="OrthoDB" id="56889at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="350" mass="40392" checksum="642E505C97AED5C2" modified="2011-05-03" version="1">MLFDLRPKSRREDIFDREKEFEELEESIKTYPLTLLLGIRRVGKSSILRAYLNEKPGVLIDCRELYGERGHITREDLIRELQTGGSLFSKALAKFRISVDLKFLKLEPKELSLREIFRELNELGEKTGGFILAFDEAQYLRFYGSRGGKDLLALFAYAYDNLPSLKIVLTGSEVGLLHDFLDIGNYESPLYGRIAGEVYVKPFDKNTSIKFLKKGFNEVGIDILEDDLERAVKILDGIPGWLVTFGIEYTKERNLEKAIARTLEIAKGLIFGELKELERRSPRYMIILQAIALGYNRWSLIRDYLAVKGYKTPEPRLHELLKNLKKMSWIEEKDETYHLTDPVVSIILKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMC0</accession>
    <name>F0LMC0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyadenylation specificity factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_02169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468439.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02169"/>
    <dbReference type="EnsemblBacteria" id="ADT85143">
        <property type="protein sequence ID" value="ADT85143"/>
        <property type="gene ID" value="TERMP_02169"/>
    </dbReference>
    <dbReference type="GeneID" id="10042484"/>
    <dbReference type="KEGG" id="tba:TERMP_02169"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2164"/>
    <dbReference type="eggNOG" id="arCOG00543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_5_1_2"/>
    <dbReference type="OMA" id="YLDGMIW"/>
    <dbReference type="OrthoDB" id="5321at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019975">
        <property type="entry name" value="aCPSF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033769">
        <property type="entry name" value="KH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17214">
        <property type="entry name" value="KH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03675">
        <property type="entry name" value="arCOG00543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="102"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="198"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="3">
        <location>
            <begin position="433"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT85143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="648" mass="73343" checksum="55FB9D3A1E8C7ABE" modified="2011-05-03" version="1">MIKRESFVDDILKEMREIINQMVPREAKITDIEFEGPELVIYVKNPEAIMQDGDLIKNLAKVLKKRISVRPDPDVLLPPERAEGLIKEIVPSEAEITNISFDPSVGEVIIEAKKPGLVIGKNGETLRKITQKVHWAPRVVRTPPLQSQTIYSIRQILQTESKDRRKFLRNVGRNIYRKPELKSEWIRITGLGGFREVGRSALLVQTNESFVLVDFGINVAALNDPKKAFPHFDAPEFRYVLNEGLLDAIIITHAHLDHSGLLPYLFRYNLFDGPIYTTPPTRDLMVLLQKDFIEIQQSNGAEPLYKPKDIKEVVKHTITLDYGEVRDISPDMRLTLHNAGHILGSAIVHLHIGNGLHNVAVTGDFKFIPTRLFEPANARFPRLETLIMESTYGGSNDYQMPREDAEKKLIEVIHQTIKRKGKVLIPAMAVGRAQEIMMVLEEYARVGGIEVPIYLDGMIWEATAIHTAYPEYLSKHLRDQIFHEGYNPFLNEIFKPVANSKERQDIIDSEEPAIIIASSGMLVGGPSVEYFKQLAPDPRNSIIFVSYQAEGTLGRQVQRGLKEIPTIGEGGRTEVIRVNMEVHTIDGFSGHADRRELMSYVAKVRPRPERVITVHGEPQKCLDLASSLHKRFSISTRAPNNLDAIRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMD6</accession>
    <name>F0LMD6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coenzyme A-dependent NAD(P)H sulfur oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_02185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468455.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02185"/>
    <dbReference type="EnsemblBacteria" id="ADT85159">
        <property type="protein sequence ID" value="ADT85159"/>
        <property type="gene ID" value="TERMP_02185"/>
    </dbReference>
    <dbReference type="GeneID" id="10042500"/>
    <dbReference type="KEGG" id="tba:TERMP_02185"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2180"/>
    <dbReference type="eggNOG" id="arCOG01069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_3_2"/>
    <dbReference type="OMA" id="WVSHAPC"/>
    <dbReference type="OrthoDB" id="40511at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050451">
        <property type="term" value="F:CoA-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017758">
        <property type="entry name" value="CoA_disulphide_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03385">
        <property type="entry name" value="CoA_CoA_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="4"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="326"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT85159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="441" mass="48799" checksum="415F4476D5A24456" modified="2011-05-03" version="1">MSRRVVIIGGGAAGMSAASRVKRLKPDWDVKVFEATEWVSHAPCGVPYVVEGISPKEKLMHYPPEFFRKKRGIDLHLNAKVVEVEQGQVRVQEKDGEHKYEWDYLVFANGASPKLPPIEGIDLKGVFTADLPPDAVAIREYMQEYDVKDVVVIGTGYIALEMAEAFVAQGKNVTLIGRSERVLRKSYDKEITDIVEAKLREHLNLRLQELTIRIDGKERVEKVVTDANEYKADLVVIATGIKPNIELAKQLGVRIGETGAIWTNEKMQTSVENVYAAGDVAETKHIITGRRVWVPLAPPGNKMGYVAGSNIAGKEIRFPGVLGTSITKFMDLEIGKTGLTESEALKEGYDVKTAFIEARTKPHYYPGGKKIWLKAVADKETNRLLGLQAVGSDVLPRIDAFAVALQAGFTVKDLFFADLAYAPPFAPVWDPLIVLARVLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LME6</accession>
    <name>F0LME6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468465.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02195"/>
    <dbReference type="EnsemblBacteria" id="ADT85169">
        <property type="protein sequence ID" value="ADT85169"/>
        <property type="gene ID" value="TERMP_02195"/>
    </dbReference>
    <dbReference type="GeneID" id="10042510"/>
    <dbReference type="KEGG" id="tba:TERMP_02195"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2190"/>
    <dbReference type="eggNOG" id="arCOG05855">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_923236_0_0_2"/>
    <dbReference type="OMA" id="IIQTIYG"/>
    <dbReference type="OrthoDB" id="46061at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="300" mass="33191" checksum="974D404F6E8DA8B4" modified="2011-05-03" version="1">MKYSKLAVELLKGAEQVIYYDPVYHGRTLKIFGIDNDPTKLVKYLADKYLEKDYGIVIFDTTGDYPKEGFESIIKIEDGKPTGLDPIKMAEEGIIDDPYTAVTIVQTIYELDRSLTEKLYADVLFGKIESVSQAASSEEKYGEVIRESYTVLDEEFFQGSTPNFGNSILVDLSGAHSITIVGMAFLIVAAVVRKRRHVFIGLDDAAVLSYTPAGSAAIPLLTQPMRGRVTVLATRYTVESILNISGPTLVLYTDPDIQSLIYESNGVPPGAMRKRVLKGEGAFIWRTPETINVEEGELLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMH3</accession>
    <name>F0LMH3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sarcosine oxidase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467250.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00976"/>
    <dbReference type="EnsemblBacteria" id="ADT83952">
        <property type="protein sequence ID" value="ADT83952"/>
        <property type="gene ID" value="TERMP_00976"/>
    </dbReference>
    <dbReference type="GeneID" id="10041293"/>
    <dbReference type="KEGG" id="tba:TERMP_00976"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.979"/>
    <dbReference type="eggNOG" id="arCOG00755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_4_1_2"/>
    <dbReference type="OMA" id="PDHNALI"/>
    <dbReference type="OrthoDB" id="45129at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="379" mass="42234" checksum="7D5431646395736E" modified="2011-05-03" version="1">MRSEIVIIGGGIVGVTLAYELAKRGEQVTVLEKKYIGSGSTFRCGTGIRQQFTDEANIKVMKRSVELWKKYSEELGFPFKQTGYLFLLYDDEEVKEFKKNIKLQNRLGVPTRLITPEEAKEIVPVLDTSEVIAASWNPTDGKADPFFATTAFAREAEKLGAEILEYTEAKDIIVEEGEIKGVKTNKGMIETGIIVNAANAWAKLINAMAKIPIKIPIEPYKHQGVITQPLKEGQINPMVISLKYNDAYLTQTEHGGIIGGVGVEYGPTYDLTPTYEFIREVSKAFIKIIPVLGELLILRTWAGFYAKTPDSNPAIGRIEEIDEFYIAAGFSGHGFMMAPAVAEMLADLITKGRTDLPVEWYDPYRFERGELRETALQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMI2</accession>
    <name>F0LMI2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PspC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467259.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00985"/>
    <dbReference type="EnsemblBacteria" id="ADT83961">
        <property type="protein sequence ID" value="ADT83961"/>
        <property type="gene ID" value="TERMP_00985"/>
    </dbReference>
    <dbReference type="GeneID" id="10041302"/>
    <dbReference type="KEGG" id="tba:TERMP_00985"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.988"/>
    <dbReference type="eggNOG" id="arCOG03456">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099432_1_0_2"/>
    <dbReference type="OMA" id="WIVVPEN"/>
    <dbReference type="OrthoDB" id="118974at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PspC" evidence="6">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="153" mass="17376" checksum="9D312F3BC3E09C53" modified="2011-05-03" version="1">MEKRRLYRSKDEKIFLGVLGGIAKYLDVDPTLVRIIYVILLFLAPVTAILMYFALALIMPEEPEEEISFDKLPEKAEKIAKEIDETLTQAFSSKKPASTVKDHNNEKLLAIILIVLGGVLILRKITPFMWYLQGDILLAVLLLLFGIYLLIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMI9</accession>
    <name>F0LMI9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467266.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00992"/>
    <dbReference type="EnsemblBacteria" id="ADT83968">
        <property type="protein sequence ID" value="ADT83968"/>
        <property type="gene ID" value="TERMP_00992"/>
    </dbReference>
    <dbReference type="GeneID" id="10041309"/>
    <dbReference type="KEGG" id="tba:TERMP_00992"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.995"/>
    <dbReference type="eggNOG" id="arCOG01229">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046378_0_0_2"/>
    <dbReference type="OMA" id="ECTIEER"/>
    <dbReference type="OrthoDB" id="39434at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="450" mass="51030" checksum="2B70B3896E92541C" modified="2011-05-03" version="1">MAEKKRKRVIILGAAGRDFHNFNVFFRNNPDYEVVAFTATQIPDIEGRIYPPELAGPLYPNGIPIWSEDDLEKIIKEHDIDIAVFAYSDVSHEHVMHLASRAHAAGADFWLLGPKSTMLKSSKPVIAVTAVRTGSGKSQTSRKVAKILKDLGYKVAVIRHPMPYGDLRKQIVQRFATYEDLDKYECTIEEREEYEPHIDYGHVVYAGVDYEKILREAEKEADIILWDGGNNDFPFYEPDLWIVVADPHRPGHELKYHPGETNFRSADVIIINKVETAYPENVQKVRENIEKVNPNAIVIEAASPIFVDKPELIKGKRVLVVEDGPTLTHGGMKYGAGYVAAKKFGAKEIIDPRPYAVGSIVETYKKYPHLDVILPAMGYGKKQIKELEETINRADADVVVIGTPIDLRRILNINKPAVRVRYELEEIGQPKLYDILKDFVEKCEKLKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMP2</accession>
    <name>F0LMP2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467319.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01045"/>
    <dbReference type="EnsemblBacteria" id="ADT84021">
        <property type="protein sequence ID" value="ADT84021"/>
        <property type="gene ID" value="TERMP_01045"/>
    </dbReference>
    <dbReference type="GeneID" id="26136496"/>
    <dbReference type="KEGG" id="tba:TERMP_01045"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1048"/>
    <dbReference type="eggNOG" id="arCOG02177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086260_0_0_2"/>
    <dbReference type="OMA" id="GYWEQHP"/>
    <dbReference type="OrthoDB" id="32299at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002749">
        <property type="entry name" value="DUF63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40700">
        <property type="entry name" value="PTHR40700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01889">
        <property type="entry name" value="DUF63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="268" mass="31155" checksum="40AA1C61C5995B13" modified="2011-05-03" version="1">MGVSEIFQKYFVNPIKYNTGYNVVNTLTYAIILGIAALGVYKILKRLGIKYDNAFFRALIPYMIFGAFTRALTDATIYPRTYLTVTPGIYVVTFAITFTALLITHKLFEDWRRVFLYFGWALVGFDFVMLLTHLDKVHFTWIVLKYFIPALIIAESVIYLMTKKIELVRENSYLFYAHFYDATTTFVGIQFMGYWEQHVLPRFLMNLTGTAAVMYLLKFVTLMVALYLMKELQETESDKELMDFIKTVIFILGFAPGTRNLLRMLMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMP8</accession>
    <name>F0LMP8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rad21_Rec8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467325.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01051"/>
    <dbReference type="EnsemblBacteria" id="ADT84027">
        <property type="protein sequence ID" value="ADT84027"/>
        <property type="gene ID" value="TERMP_01051"/>
    </dbReference>
    <dbReference type="GeneID" id="26136503"/>
    <dbReference type="KEGG" id="tba:TERMP_01051"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1054"/>
    <dbReference type="eggNOG" id="arCOG02610">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070251_1_1_2"/>
    <dbReference type="OMA" id="GKVDPWN"/>
    <dbReference type="OrthoDB" id="81037at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21_Rec8" evidence="1">
        <location>
            <begin position="167"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="218" mass="25995" checksum="E89A8793694F1BB5" modified="2011-05-03" version="1">MERRYEEEITPVDILLQLVTMGKVDPWNIDIVDLTEKYIERLREMKELDLRLSARAILAASILLRMKTEALLYADEEKEEEKKEERIRVDVEPYVPPLRRVERYYTLDDLIEALMDALEDVEKRKPKVKKKVEIEEEIFVVDDFRVDIEKHVNRLYAIVKRLYEETKEKISFWELVFDPSPKIVARTFLYLLFLANMGKVELIQEEPFGDIYVVPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMQ0</accession>
    <name>F0LMQ0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467327.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01053"/>
    <dbReference type="EnsemblBacteria" id="ADT84029">
        <property type="protein sequence ID" value="ADT84029"/>
        <property type="gene ID" value="TERMP_01053"/>
    </dbReference>
    <dbReference type="GeneID" id="10041370"/>
    <dbReference type="KEGG" id="tba:TERMP_01053"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1056"/>
    <dbReference type="eggNOG" id="arCOG01206">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_10_0_2"/>
    <dbReference type="OMA" id="RALHPMM"/>
    <dbReference type="OrthoDB" id="108083at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="96" mass="11000" checksum="5DE1EB0580299BDD" modified="2011-05-03" version="1">MKLEGILKVLEELKPELKSKYKVKSLAVFGSYVRGEQRETSDVDVLVEFSEDADLFDLIALEEFLTEKLGIKVDVVPKNALRKELRQSVFREAIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMU1</accession>
    <name>F0LMU1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467368.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01094"/>
    <dbReference type="EnsemblBacteria" id="ADT84070">
        <property type="protein sequence ID" value="ADT84070"/>
        <property type="gene ID" value="TERMP_01094"/>
    </dbReference>
    <dbReference type="GeneID" id="10041411"/>
    <dbReference type="KEGG" id="tba:TERMP_01094"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1097"/>
    <dbReference type="eggNOG" id="arCOG01346">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095994_2_1_2"/>
    <dbReference type="OMA" id="FKPREGW"/>
    <dbReference type="OrthoDB" id="114057at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01103">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75471">
        <property type="entry name" value="SSF75471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51295">
        <property type="entry name" value="CRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CRM" evidence="3">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="138" mass="16330" checksum="CA185F1943EDD883" modified="2011-05-03" version="1">MEKRLPGKVRRAIRAKYYDIQPKAWIGKKGLEEGVINEINTQLKKDGILKVEIRKGALIATGMDRKRIAEKVAELTDSELIEVRGKRFILFRPREGWEKYLRKLKLKELSKEKREEKPVKKVRLDIAQFRKKFKKGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMU5</accession>
    <name>F0LMU5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="92" mass="10776" checksum="91AF158BFB14C4ED" modified="2011-05-03" version="1">MDIKRVIKELNEKGEISLETWKPLSAKKNGDGTVDILYRNLLLGDENDPVFLWVYVNIIEEDEEDTEVRILERMTFKKEDLAWVAKFVSKFG</sequence>
</entry>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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            </authorList>
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            <begin position="12"/>
            <end position="33"/>
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            <end position="94"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="94" mass="11041" checksum="1B55694A8F89659E" modified="2011-05-03" version="1">MEEKDKKLIESGIEALILGWLAYLFFYQNFLLYKWHRGLLLPSKIPFLVAGILVGLAYFLYRWEKIEKEIPKEVPKGTSAPQEIPEEKEKELKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMY8</accession>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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            </authorList>
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        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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            <begin position="37"/>
            <end position="59"/>
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        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="137" mass="14899" checksum="229010BAD9346F03" modified="2011-05-03" version="1">MSEVVTFIWAVIILSLIATIVISLYGIARRPNLVKKLIALTIFGDTANLLVVLLGYRLIYPVAPPILPSLSKESLQQFVSTAVDPLPQALVITAVVIGMAVNVLIAFAIIQIYRLYGTVDTRELGKKLPAILRGESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN05</accession>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="391623.TERMP_01158"/>
    <dbReference type="EnsemblBacteria" id="ADT84134">
        <property type="protein sequence ID" value="ADT84134"/>
        <property type="gene ID" value="TERMP_01158"/>
    </dbReference>
    <dbReference type="GeneID" id="26136621"/>
    <dbReference type="KEGG" id="tba:TERMP_01158"/>
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    </dbReference>
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    </dbReference>
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            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84134.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="287" mass="32775" checksum="382F595C3B0567D9" modified="2011-05-03" version="1">MTIVDVRILVEGASDVEVVSKALQGLALGSEYNITISSIIPTTNLEIAKSAAAGADLLIIATDADRVGRELADRLFRELSELVGHVERMKIPLGHDLEHIDVELVRKELKNTLVRAGLKSLQLLPEYMALRNQLLDLKGKYDMLEQEKHSLENQLQEIEQKYEELKQEYQRLKDENENLKILLDKRSNLVKIEEAWKQIFPGEAVPNEEIIGKAVERLGLQGRVIVGQGYIYAEEERLIEELLKIVYLTMTIAKPEGREPPEERADESERIEETKETEVFHEKIEEL</sequence>
</entry>
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            <taxon>Euryarchaeota</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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                <person name="Marteinsson V.T."/>
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                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="gene ID" value="TERMP_01162"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="121018at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="201" mass="23209" checksum="B87BFB24EA7AC499" modified="2011-05-03" version="1">MELSEAINKRTSVRFYEEREVDEETLRELIKAAIRAPTASGLENWLFVAYKSKDIREKLYELIKQGHIEYFTERGLPEEKMKKLLKRFEEGMYKAPIYLGVFINKNVKALKDEKYSELEFCFALESAAMAIENLMLKAVELGLGTCYIGVACFEQIEKELKKMAGLGEEYFLVGLITIGYPKGEISPRERKKSVEEVLKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN10</accession>
    <name>F0LN10_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467437.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01163"/>
    <dbReference type="EnsemblBacteria" id="ADT84139">
        <property type="protein sequence ID" value="ADT84139"/>
        <property type="gene ID" value="TERMP_01163"/>
    </dbReference>
    <dbReference type="GeneID" id="26136626"/>
    <dbReference type="KEGG" id="tba:TERMP_01163"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1166"/>
    <dbReference type="eggNOG" id="arCOG08604">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157021_0_0_2"/>
    <dbReference type="OMA" id="HIFEMNE"/>
    <dbReference type="OrthoDB" id="124891at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="106" mass="11931" checksum="B88DD4A2396A2465" modified="2011-05-03" version="1">MIEFVILLGIIGGWVIFASTLFLMLALGKMWGLLGIALLIAGIEINHKLKAKYMKAVMDYSPRAKELAMHIFEMNELILMSSYVIALALYAVIQKYIEIMIKLPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN28</accession>
    <name>F0LN28_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467455.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01181"/>
    <dbReference type="EnsemblBacteria" id="ADT84157">
        <property type="protein sequence ID" value="ADT84157"/>
        <property type="gene ID" value="TERMP_01181"/>
    </dbReference>
    <dbReference type="GeneID" id="10041498"/>
    <dbReference type="KEGG" id="tba:TERMP_01181"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1184"/>
    <dbReference type="eggNOG" id="arCOG00959">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1850741_0_0_2"/>
    <dbReference type="OMA" id="PFKKRYG"/>
    <dbReference type="OrthoDB" id="101311at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="134" mass="15835" checksum="23BDBB9E33A42631" modified="2011-05-03" version="1">MSETKSWKEYYDYMEQKTPLTIYYPICGGGEECITACPYGEKIWDVEPMKVSLFGFNQKVRLRPVMKNPELCKECYLCVEACPTGALRPKDKPANHPLLTLVYNTLKLPFKRRYNIKFVFRPEHVEKFRRNNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN44</accession>
    <name>F0LN44_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF553 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0252 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467471.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84173">
        <property type="protein sequence ID" value="ADT84173"/>
        <property type="gene ID" value="TERMP_01197"/>
    </dbReference>
    <dbReference type="GeneID" id="10041514"/>
    <dbReference type="KEGG" id="tba:TERMP_01197"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1200"/>
    <dbReference type="eggNOG" id="arCOG02164">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045499_0_0_2"/>
    <dbReference type="OMA" id="PYNNTIQ"/>
    <dbReference type="OrthoDB" id="66569at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007562">
        <property type="entry name" value="Transglutaminase-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04473">
        <property type="entry name" value="DUF553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF553" evidence="3">
        <location>
            <begin position="91"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="380" mass="42849" checksum="4719368937ABD295" modified="2011-05-03" version="1">MKLLKFMLSALIIALVFVSGCIQIETITQTERSTSETLSTHSSTAAPSTQTTASTAVLPQVNTTSSCSDPLWRYILERAIPCALNKEELAKIKPLAEQLKGDSLQQSAWNILEWEKEHIQYDWKKASLPAPEIEMYSNGSFKVVKGKNNTVQTPYETIMKGKGICTDYAILTAGLLLDMNYSPVYIFSINFTNSDTGHAAAVIEIEGWYFVLDQHPPAMDLGAYYRYWKEKGKIISNATIYEIKLVNGSAEVKSLGIVSGIEFLKQDYKFTNADAQAIFGSLTSVILRSFPNLRLDEKLQSLSQGILPEGYSEGKVWTFRFEKFVEYYNPLFHEQLIEYLYNIIISDPEVGADLEQYSAFWIEIREEGENLKIILDIAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN68</accession>
    <name>F0LN68_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02234"/>
    <dbReference type="EnsemblBacteria" id="ADT85207">
        <property type="protein sequence ID" value="ADT85207"/>
        <property type="gene ID" value="TERMP_02234"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02234"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2228"/>
    <dbReference type="eggNOG" id="arCOG03045">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025311_0_0_2"/>
    <dbReference type="OMA" id="GIVWINE"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="474" mass="55054" checksum="3042D69A476557C1" modified="2011-05-03" version="1">MGELVKKFVKPEGITVEEFFAEGFSEKSLEDLEKAYEEAWEREKLLYADGYIKLLVSIAEYYEKRSKKGSKNEVEAFLDEYFGTSSKSPTYKKLVTKYYIKASNIATSVSLIYLSQQNNPEKAEKYLKLAVELGEKVMKLGVIPKDYSIILNILGTYYYETNRPEKALMVLKKALRYAMTPRETALTLYNLALTYAELGMNRKAIDFMVNAICIHYSTQHDFGDASLYDDDINRIIEMTGDANTDIYALKVALDLISGNLTAEEAKKLLEQIDRDEWPLTDALLSILNGEECMLSIDLVECITLLQDIAKIVGNENALKLQSFYPREVEEDLKKLGEYIRGKCGNVQHLTWEISVTHNLESRIKVNYVSKECYYLVGSYEELTFSWFMKRRNWRWRIKGIVWINEKPHILLGKVKKQRLWYALYNIDMSEPKIFNLPIPANFTGDLWNAWSDNLEKVLTNHFITEKDKFRFVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN71</accession>
    <name>F0LN71_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GGACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
            <plasmid evidence="2 3">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747432.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02237"/>
    <dbReference type="EnsemblBacteria" id="ADT85210">
        <property type="protein sequence ID" value="ADT85210"/>
        <property type="gene ID" value="TERMP_02237"/>
    </dbReference>
    <dbReference type="GeneID" id="10549061"/>
    <dbReference type="KEGG" id="tba:TERMP_02237"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2231"/>
    <dbReference type="eggNOG" id="arCOG03271">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083466_5_1_2"/>
    <dbReference type="OMA" id="FGRAILW"/>
    <dbReference type="OrthoDB" id="114717at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGACT" evidence="1">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="113" mass="13252" checksum="8CD4220371386B04" modified="2011-05-03" version="1">MKIAVYGTLRKGKPLHDYLRESKFLGEDWIEGYDLYVDVLPYAVKGEGRLKVEIYEVDEETFERISRMEVNAGYKPVEVDTKFGRAILWKWVHEPSGERVESGDFDDVEFKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN96</accession>
    <name>F0LN96_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mrr_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
            <plasmid evidence="2 3">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747457.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02262"/>
    <dbReference type="EnsemblBacteria" id="ADT85235">
        <property type="protein sequence ID" value="ADT85235"/>
        <property type="gene ID" value="TERMP_02262"/>
    </dbReference>
    <dbReference type="GeneID" id="10549086"/>
    <dbReference type="KEGG" id="tba:TERMP_02262"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2256"/>
    <dbReference type="eggNOG" id="arCOG04267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2178012_0_0_2"/>
    <dbReference type="OMA" id="QHKKAEY"/>
    <dbReference type="OrthoDB" id="143312at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="1">
        <location>
            <begin position="7"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="109" mass="12362" checksum="AFD7700F82159DB6" modified="2011-05-03" version="1">MPRNRGKGSGFEKKIASRYKRAGYFIERNKVKNGTEIDIIAKKKRQKKLVIETKAGKQVVTSSVIRKLAEVARSIKGKPVLVIGPRVSLTKPAKKEAKKRNIRIRKVYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGY0</accession>
    <name>F0LGY0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467486.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01212"/>
    <dbReference type="EnsemblBacteria" id="ADT84188">
        <property type="protein sequence ID" value="ADT84188"/>
        <property type="gene ID" value="TERMP_01212"/>
    </dbReference>
    <dbReference type="GeneID" id="10041529"/>
    <dbReference type="KEGG" id="tba:TERMP_01212"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1214"/>
    <dbReference type="eggNOG" id="arCOG03269">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027397_0_0_2"/>
    <dbReference type="OMA" id="PYPLACG"/>
    <dbReference type="OrthoDB" id="24518at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="645" mass="73056" checksum="66460CA88B447634" modified="2011-05-03" version="1">MRKVFLAVVIFLISLPQTIADSVFYGWVQIPTTITIGSTQIMLKDISGVDGSIFAVFKDDKDSNIEILPLSNYIHWEEYNLSSEYVLLINEKGYAKLKLNFPYLLEGETMRFGDYKIYLKSVTKKQAQLELSYKNITRKFTYKGGEINFENLKLSLILAPTIFDGYISRGYPKKIDEWSITFVSYNITKEDGILKEIVELKINQKTYWSEVGDVLEAEGLRIEIKDLVGSTYLRMEVELKGAYLNISLTPYFESWLSEGKTTKIGPYIVKIEKIFSDQAYVSIKNPCGMPLKSGLVKIDKFSRMLSYDGISVGFIETKEENGEKKVKTVIIIDNEKIPKIEDVAFLNVSYEVPTRATQYSTFETKVILENTGKSDLRYVEILPNVSKIFSIVNNYPRYIPTIKRGEKIELTLVLQSQAYGNLTVGNIRVLAHAPYELSCYGVGEVEFSSETKRVEILKAEPNYSIDVRTLNGTVGSPIPLNITIANLGNVDSPFDLTVALPKEFGVVAENFTIYRKWLHLRDTLKPGTSKTYKMFLISTKEGQYEVEVLVKSFGKLFQKSTTLTVTSLVKEHTENILLNQNVTCTPKVIERVVEVSKITQQNSTVTVEPVSLKWKIVYGGGFFVGGVIFILALAWIAAKLEERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGY1</accession>
    <name>F0LGY1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PUA-PAPS reductase like fusion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467487.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01213"/>
    <dbReference type="EnsemblBacteria" id="ADT84189">
        <property type="protein sequence ID" value="ADT84189"/>
        <property type="gene ID" value="TERMP_01213"/>
    </dbReference>
    <dbReference type="GeneID" id="10041530"/>
    <dbReference type="KEGG" id="tba:TERMP_01213"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1215"/>
    <dbReference type="eggNOG" id="arCOG00073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026622_0_0_2"/>
    <dbReference type="OMA" id="RWCCKVT"/>
    <dbReference type="OrthoDB" id="6490at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="565"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="597"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="630" mass="73016" checksum="7A9033A8EB72E61A" modified="2011-05-03" version="1">MRRGPVFLGKAYIHWCEKCNVPLISEKCDVHGKEGVFKLDLTPPADVRFAFEKDLEFIKREFKKHYGVNIGEIIDGKIVLLNKTPGEDDIYEIILDGYIFGWLRFDPLELKWKPGLKVEGAIALWKRFGKNMRKWVVVDEGAVEPIKKGANVLPVGIIEADPSIKIGDDVIIVSESGEVIATGIAKKDYEQLINPKERGTGIKTRHQRNIKYREGKNATIDDVIRANKSALEERVGEAREFMRRTAEKIKLPMAVAFSGGKDSLAVLGLMLEEFEEGFTIFFNNTGIEFPETLQYIEEMKKELKDKNIEFIVADAKDAFWHAINVFSPPGRDYRWCCKVTKLGPITLTIKKHYPQGVLMFVGQRKYESIQRYKQPRIWKNPWVPNEIGASPIFHWNALEVWLYIFSRKLKYNPLYEHRLDRIGCFLCPSSSLAEIYTLKEEKSGLWDKWEEELEKWRKRLNLPKEWITYGFWRWKQLSRGQKMLAEQLGIDLPEKRVWEPVKYSIEEHENGYLVKLNTAINLERIKEVAPILGEVEIGENYIKVSEIVFREEGIFAPERREGIQAYYLIKRAYECVGCGVCVGRCKENALSINPKTRKIVVDYGRCIHCRECMEVCPLLKIKNPREGSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH02</accession>
    <name>F0LH02_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467508.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01234"/>
    <dbReference type="EnsemblBacteria" id="ADT84210">
        <property type="protein sequence ID" value="ADT84210"/>
        <property type="gene ID" value="TERMP_01234"/>
    </dbReference>
    <dbReference type="GeneID" id="10041551"/>
    <dbReference type="KEGG" id="tba:TERMP_01234"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1236"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="EFFSHDK"/>
    <dbReference type="OrthoDB" id="51469at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="275" mass="30844" checksum="4B0421152F63D85C" modified="2011-05-03" version="1">MPIVKIRNVSKRFGDVVALRNIDLEIEQGEFVVIAGENGSGKSTLLKIMTGLLIPDNGEVTVLGFDVVEEWKELAKHIGVALANERSLYWKLTGMENLEIFGGIYGVRDAKKKALALLERLDLIDVKDMLVENYSTGMRRKLLLAKSLIHSPKILFLDEILNGLDPKSMIEIVSFLEELNRDGITIVLVSHILHSLPSNSRLIVMKDGKIILDDALRNFKNMKTVKVKAVIGGEKIEKTVDESELTKVIKELTEVGAENIMIERDDLYAILRRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH24</accession>
    <name>F0LH24_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467530.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01256"/>
    <dbReference type="EnsemblBacteria" id="ADT84232">
        <property type="protein sequence ID" value="ADT84232"/>
        <property type="gene ID" value="TERMP_01256"/>
    </dbReference>
    <dbReference type="GeneID" id="10041573"/>
    <dbReference type="KEGG" id="tba:TERMP_01256"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1259"/>
    <dbReference type="eggNOG" id="arCOG02835">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097044_0_0_2"/>
    <dbReference type="OMA" id="PFGKYYY"/>
    <dbReference type="OrthoDB" id="84226at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007354">
        <property type="entry name" value="CruF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39419">
        <property type="entry name" value="PTHR39419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04240">
        <property type="entry name" value="Caroten_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="229" mass="26547" checksum="E942601FB4EFFE0F" modified="2011-05-03" version="1">MKADIKIALVFIVLANIMKKSPVYLLLYLFGFAILSQRAWKSLPKLLLWALVVGFSAEIIGTHVCLPFGCYEYVNLRPQIFGVGLFVPLAWGIFGAVAYLTASYFFRNWGKRLLFAALLMVIIDLSVDPIMTSWKAWIWKRTTAINWFGIPWTNYLGWFVVSLIFFYLYERFSRVEVEDALLKLGPPIYLLEMLTFMIYAPQSVRTPTEIAFLMSLAVILPLYLWRRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH30</accession>
    <name>F0LH30_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01262"/>
    <dbReference type="EnsemblBacteria" id="ADT84238">
        <property type="protein sequence ID" value="ADT84238"/>
        <property type="gene ID" value="TERMP_01262"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01262"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1265"/>
    <dbReference type="eggNOG" id="arCOG03808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096716_0_0_2"/>
    <dbReference type="OMA" id="MYDAFSL"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="251" mass="28370" checksum="EFB3DAAE04CF2712" modified="2011-05-03" version="1">MVKTLYNELDEVMGGGLSQGSAMAILYDTYSFAQYFALHILAKRIKKGDLGIISNYSYPIGRLIRGAQFAGLDLVSEGKEGNLFVIDYFSSRYGIMPRYPFVYTFSGHVGEETLNPKTFLIYQEKILPNLGDRLLVRVIYTLDGLAFFFGENTALKLLYFDLAKFMDMFPNSVTILLVNKDAVSKHFVARVVDISDYVIDFRSQVTKKGIVEDVIISKALTPEFSPEIFEFLIGETEKEKGGKFSFKKVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH34</accession>
    <name>F0LH34_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
            <shortName evidence="5">HPPK</shortName>
            <ecNumber evidence="5">2.7.6.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">6-hydroxymethyl-7,8-dihydropterin diphosphokinase</fullName>
            <shortName evidence="5">6-HMPDK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">7,8-dihydro-6-hydroxymethylpterin diphosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase</fullName>
            <shortName evidence="5">PPPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mptE</name>
        <name evidence="7" type="ordered locus">TERMP_01266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal 6-HMPDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467540.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01266"/>
    <dbReference type="EnsemblBacteria" id="ADT84242">
        <property type="protein sequence ID" value="ADT84242"/>
        <property type="gene ID" value="TERMP_01266"/>
    </dbReference>
    <dbReference type="GeneID" id="10041583"/>
    <dbReference type="KEGG" id="tba:TERMP_01266"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1269"/>
    <dbReference type="eggNOG" id="arCOG04303">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093043_0_0_2"/>
    <dbReference type="OMA" id="HAHGDNM"/>
    <dbReference type="OrthoDB" id="105604at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02131">
        <property type="entry name" value="HMPDK_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027510">
        <property type="entry name" value="HMPDK_MptE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39648">
        <property type="entry name" value="PTHR39648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MAF_flag10" evidence="6">
        <location>
            <begin position="38"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="248" mass="28424" checksum="7BFA277F9CDC76FC" modified="2011-05-03" version="1">MKFEEWKPFYNEIVTTMGYDVMKDREAAEILQELLLKNKNYIKPHYLREIIEGKKVYIFGAGPSLELALKYLSFKDGIKISADGATSALLEFGLVPDIVVTDLDGRFEDIRRADLLGAYIVVHAHGDNIEKLKEYVPQLEKVLGTCQTEPLDIVHNFGGFTDGDRAVFLAEEFGAEEIILVGFDFGDVVGKWSKPHLKEHAPIWESKRKKFEFAQKLLQWLKKNGKAKIRRIVCHPIDYAISKCYIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH35</accession>
    <name>F0LH35_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467541.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01267"/>
    <dbReference type="EnsemblBacteria" id="ADT84243">
        <property type="protein sequence ID" value="ADT84243"/>
        <property type="gene ID" value="TERMP_01267"/>
    </dbReference>
    <dbReference type="GeneID" id="10041584"/>
    <dbReference type="KEGG" id="tba:TERMP_01267"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1270"/>
    <dbReference type="eggNOG" id="arCOG05734">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010555_0_0_2"/>
    <dbReference type="OMA" id="FQFRFPY"/>
    <dbReference type="OrthoDB" id="50288at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="274" mass="32024" checksum="CE8D847CD6DB4A80" modified="2011-05-03" version="1">MRFATKNEAVKDAFINELKNSGIRFKVKERLSYETFIGYMIEGTLEEIRAQIDALSGEEKEVILRGFQSFKEQIFHALEHLKEGETFENLLSEGYWMGDIIDQLMKNSALDIKENKVKLKERIDATKLKFQFRFPYELAKQVDVIEKVAKQFAFIDLVPEWEIEIKELRIERVNQALQIAAKYFPEKDVMNVYFALIGKSILANEILKSLGNEKIPVDVIIKEFLRIFPFEIPTERGVMVINATERSLYAILKELEKFGYIDIKGNKVRKIREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH40</accession>
    <name>F0LH40_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gpmA</name>
        <name evidence="6" type="ordered locus">TERMP_01272</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467546.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01272"/>
    <dbReference type="EnsemblBacteria" id="ADT84248">
        <property type="protein sequence ID" value="ADT84248"/>
        <property type="gene ID" value="TERMP_01272"/>
    </dbReference>
    <dbReference type="GeneID" id="10041589"/>
    <dbReference type="KEGG" id="tba:TERMP_01272"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1275"/>
    <dbReference type="eggNOG" id="arCOG01993">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_1_4_2"/>
    <dbReference type="OMA" id="RMLPYWY"/>
    <dbReference type="OrthoDB" id="61359at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="235" mass="27313" checksum="C2C79B56C7B1B90F" modified="2011-05-03" version="1">MALLVLVRHGESLWNRLNIFTGWVDIPLSENGIREALKAGDLLKDYKFDVIFTSELVRAIQTAMLIMSRNKHGVAKIEHENGKMKEWGTVYGEHGRNYIPVYKAWQLNERYYGKLQGWNKDYARKVYGDEQVLLWRRSYDIAPPGGESLKDTAKRTIPYLKERIIPELEKGKNVLVSAHGNSLRSVVMHIENLTKEEVLRLNIPTGIPLIYEYKNRKLIRKGYLTERGFINKLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHD0</accession>
    <name>F0LHD0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467555.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01282"/>
    <dbReference type="EnsemblBacteria" id="ADT84257">
        <property type="protein sequence ID" value="ADT84257"/>
        <property type="gene ID" value="TERMP_01282"/>
    </dbReference>
    <dbReference type="GeneID" id="10041598"/>
    <dbReference type="KEGG" id="tba:TERMP_01282"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1284"/>
    <dbReference type="eggNOG" id="arCOG01130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_2"/>
    <dbReference type="OMA" id="SVAMTGW"/>
    <dbReference type="OrthoDB" id="32104at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="391" mass="44706" checksum="9BE6FAF28CEBF7F8" modified="2011-05-03" version="1">MRYKRHRYFIAERVNLIQRSKIRELFEKARKIENVISLGIGEPDFDTPDNIKEAAKRALDEGWTHYTPNAGIPELRQAISEYYREMYNLDVPTDNIIVTAGAYEATYLAFETLLERGDEVIIPDPAFVCYAEDAKLAEAGIVRLPLREENGFQPDPDELLELITKRTRMIVINYPNNPTGATMDEETAKAVADIAEDYNLYILSDEPYEHFLYDGAKHYPMLKYAPDNTILANSFSKTFAMTGWRLGFAIAPKDIIRDMIKLHAYVIGNVASFVQVAGIEALRSPKSWEAVEKMREEYAERRKIVLDAIKEMPYISAFEPKGAFYIFANIKETGMTSEEFSEWLLEKAKVVVIPGTAFGKNGEGYVRISYATKKEKLIEAMKRMKKALEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHE1</accession>
    <name>F0LHE1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01293"/>
    <dbReference type="EnsemblBacteria" id="ADT84268">
        <property type="protein sequence ID" value="ADT84268"/>
        <property type="gene ID" value="TERMP_01293"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01293"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1295"/>
    <dbReference type="eggNOG" id="arCOG00545">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050517_0_0_2"/>
    <dbReference type="OMA" id="FYIDPWR"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="290" mass="32888" checksum="08060F1264B4FE15" modified="2011-05-03" version="1">MMIIYGIGLDSSARVTFQSHAHSDHFVSGNIIFSTKATKFLSHLKKSGLYKVVKFGKTFYLGDYKAKLYPAGHMLGSAQIYIEFDEFSLLYTGDVKWFKLRTAEKSRFRKADVLIIEATFGVPMYNFPSPKEAEKKLIAFVESALDKRKTPTLYANQMGKAQELLKILEVHGYTVKASRSIIKVAKVYEKFGIKFGNIDRNGEVVLRGFRTPKPENSLSPSELYVSGFGNLKLSNHADFWELIKIIEKVKPEKIYTVYGYAENFAKILRGLGYDATAIDRDCCLSCYKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHE4</accession>
    <name>F0LHE4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NitrOD5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467569.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01296"/>
    <dbReference type="EnsemblBacteria" id="ADT84271">
        <property type="protein sequence ID" value="ADT84271"/>
        <property type="gene ID" value="TERMP_01296"/>
    </dbReference>
    <dbReference type="GeneID" id="10041612"/>
    <dbReference type="KEGG" id="tba:TERMP_01296"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1298"/>
    <dbReference type="eggNOG" id="arCOG07117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2284905_0_0_2"/>
    <dbReference type="OMA" id="LEMVIIN"/>
    <dbReference type="OrthoDB" id="118971at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021609">
        <property type="entry name" value="NitrOD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044908">
        <property type="entry name" value="NitrOD5-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11537">
        <property type="entry name" value="NitrOD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NitrOD5" evidence="1">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="99" mass="11361" checksum="FD8C1250A80AA1D6" modified="2011-05-03" version="1">MSSAEDIVVRAVTYAVEKANPTLKNLLEFHLKTTTGKGYELAYEDPKMFKEAVSKLFGEYSGRLLEMLIISYFKEKVGLKENIEDLEDLVEYVKKIYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHQ7</accession>
    <name>F0LHQ7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exosome complex component Rrp42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rrp42</name>
        <name evidence="6" type="ordered locus">TERMP_00164</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family. Rrp42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466439.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00164"/>
    <dbReference type="EnsemblBacteria" id="ADT83141">
        <property type="protein sequence ID" value="ADT83141"/>
        <property type="gene ID" value="TERMP_00164"/>
    </dbReference>
    <dbReference type="GeneID" id="26135493"/>
    <dbReference type="KEGG" id="tba:TERMP_00164"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.165"/>
    <dbReference type="eggNOG" id="arCOG01574">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_0_0_2"/>
    <dbReference type="OMA" id="PESVFEM"/>
    <dbReference type="OrthoDB" id="64101at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11365">
        <property type="entry name" value="RNase_PH_archRRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00622">
        <property type="entry name" value="Exosome_Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020869">
        <property type="entry name" value="Rrp42_archaea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="4">
        <location>
            <begin position="29"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="5">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="270" mass="29700" checksum="8BF1E8DE09F8D155" modified="2011-05-03" version="1">MEVMASIMKDHIVELLKEKKRIDGRSLEDLRPLEVKVNVIEKAEGSAWVKLGNTQVLVGIKLDLGEPFPDLPDKGVMTTNVELVPLASPTFEPGPPDERAIELARVVDRGIRESQAIDLEKLVIIPGKLVRVVFIDVHVLDHDGNLVDATGIGAIAALLSTKMPKIEYNEETGEVMMLDEYEPLPVTKIPIPVSFAKIGGTIVVDPNLEEEHVMDGKLTITTDENGYISAVQKSEGGSFKLEEVMYAVDVAFKKAQEIREKILEAVGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHR8</accession>
    <name>F0LHR8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466450.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00175"/>
    <dbReference type="EnsemblBacteria" id="ADT83152">
        <property type="protein sequence ID" value="ADT83152"/>
        <property type="gene ID" value="TERMP_00175"/>
    </dbReference>
    <dbReference type="GeneID" id="10040493"/>
    <dbReference type="KEGG" id="tba:TERMP_00175"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.176"/>
    <dbReference type="eggNOG" id="arCOG03827">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065737_0_0_2"/>
    <dbReference type="OMA" id="YLAYYMA"/>
    <dbReference type="OrthoDB" id="37379at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="356" mass="40389" checksum="031438E34EBF00A0" modified="2011-05-03" version="1">MREIEKLIKERKIKDAIEVALKMENTILKLEVLAYILRSVDNRDHQEFIFSQMFEVAESLDRPQDKAVAHAILAYSAYVMGKEKVDEHLFQKAVDVAKSLPHPSWKADALADIAYYMAKADLFEESFKTFLLAYNTIKSSKEPYSITVSVLSNIAKRLVRAGDSIPNSLSIQFYSLAKEIYQSIRFMTQAKLVNEKIEFVQNVLKRKNLAIAEFLGKGDIEKAITSIRYLDPKERVLGLLEISYWLILHDKPELARKILTDAFNMMLTGKFKPNDMELVRVAQKFMKIGLLEDALILAGIIEDRVKASEVLGDIALTYARFGKKEKALSIAEGIQNETVKSRVLKALKGEGNVGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHR9</accession>
    <name>F0LHR9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466451.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00176"/>
    <dbReference type="EnsemblBacteria" id="ADT83153">
        <property type="protein sequence ID" value="ADT83153"/>
        <property type="gene ID" value="TERMP_00176"/>
    </dbReference>
    <dbReference type="GeneID" id="10040494"/>
    <dbReference type="KEGG" id="tba:TERMP_00176"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.177"/>
    <dbReference type="eggNOG" id="arCOG04359">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110988_0_0_2"/>
    <dbReference type="OMA" id="WDTSKDY"/>
    <dbReference type="OrthoDB" id="88074at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041169">
        <property type="entry name" value="Alpha_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18489">
        <property type="entry name" value="Alpha_Helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="241" mass="26742" checksum="AB1437EF32A6B67B" modified="2011-05-03" version="1">MWDTSKDYRLLTAEKAVELFLKTIEHAKFKGRWDKKKAIKLAKEMIPELQAMRYSYLDPKELIDTPQMEALKEKAQGIIEALGGEEWHHKFLSLADKSEKEKVEEAVAKVRFFLNTILNLDKRLALGKINDPVIAVDIKVGEVMSVGKHPNADRLLVCNVNIGDRAITVVTNDLTVKEGNRVAVALLPPANFRGIVSEGMFLGAGDGVLKDVKGEIGGLPKGIPLDALKETRNLVEAFLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHT4</accession>
    <name>F0LHT4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitro_FeMo-Co domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467632.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01359"/>
    <dbReference type="EnsemblBacteria" id="ADT84334">
        <property type="protein sequence ID" value="ADT84334"/>
        <property type="gene ID" value="TERMP_01359"/>
    </dbReference>
    <dbReference type="GeneID" id="10041675"/>
    <dbReference type="KEGG" id="tba:TERMP_01359"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1359"/>
    <dbReference type="eggNOG" id="arCOG02734">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104194_2_2_2"/>
    <dbReference type="OMA" id="ISPHFGG"/>
    <dbReference type="OrthoDB" id="120742at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00851">
        <property type="entry name" value="MTH1175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033913">
        <property type="entry name" value="MTH1175_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="1">
        <location>
            <begin position="14"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="107" mass="11970" checksum="239D90AAEBC70511" modified="2011-05-03" version="1">MRITIPAKDDKGLKSEVCEHFGRAKYFVFVDVQDDKIENVETVEVPFEDHSPGDLPNFIKEHGGELVLAYGIGRRAMTYFQSLGIQVVTGAHGKIEDVVKDFMQRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHT7</accession>
    <name>F0LHT7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01362"/>
    <dbReference type="EnsemblBacteria" id="ADT84337">
        <property type="protein sequence ID" value="ADT84337"/>
        <property type="gene ID" value="TERMP_01362"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01362"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1362"/>
    <dbReference type="HOGENOM" id="CLU_3210930_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="44" mass="5042" checksum="8861326AF82233A3" modified="2011-05-03" version="1">MLEYAKLTRASAPVPMTLANQEGANPFTFIFIFIHLKKITFEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHU1</accession>
    <name>F0LHU1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome F420 hydrogenase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01366"/>
    <dbReference type="MEROPS" id="A31.003"/>
    <dbReference type="EnsemblBacteria" id="ADT84341">
        <property type="protein sequence ID" value="ADT84341"/>
        <property type="gene ID" value="TERMP_01366"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01366"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1366"/>
    <dbReference type="eggNOG" id="arCOG04429">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099037_4_1_2"/>
    <dbReference type="OMA" id="EMCAANP"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06067">
        <property type="entry name" value="H2MP_MemB-H2evol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004420">
        <property type="entry name" value="Pept_A31_hyd_mat_HycI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00142">
        <property type="entry name" value="hycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="155" mass="17026" checksum="CE3333472B9AC127" modified="2011-05-03" version="1">MLEDFLQGAKKVVICGIGNEVRGDDAFGIIVAEELKNRLKSEKIVILNCGEVPESYVGKIINEKPTHVIFIDAVDFGGKPGEVVIADPEGTLGESFSTHKLPLKLLVGYLKQNINAKFILIGCQPKQLGLFVEMSEEVKQSAEKLIEILAQELEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHU2</accession>
    <name>F0LHU2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(4)-bis(aminopropyl)spermidine synthase</fullName>
            <ecNumber evidence="1">2.5.1.128</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Branched-chain polyamine synthase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bpsA</name>
        <name evidence="3" type="ordered locus">TERMP_01367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:44132"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82771"/>
            <dbReference type="EC" id="2.5.1.128"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the branched-chain polyamine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.128" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01367"/>
    <dbReference type="EnsemblBacteria" id="ADT84342">
        <property type="protein sequence ID" value="ADT84342"/>
        <property type="gene ID" value="TERMP_01367"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01367"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1367"/>
    <dbReference type="eggNOG" id="arCOG00913">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042160_0_0_2"/>
    <dbReference type="OMA" id="KSYMFRI"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01947">
        <property type="entry name" value="Aminopropyltransf_BpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014435">
        <property type="entry name" value="BpsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002723">
        <property type="entry name" value="BpsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01861">
        <property type="entry name" value="DUF43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005895">
        <property type="entry name" value="UCP005895_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF43" evidence="2">
        <location>
            <begin position="124"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="368" mass="42665" checksum="87BB6954129CA1B0" modified="2011-05-03" version="1">MLNTLYGLFKSLKTWEVLKVREIIAKVKEKTNIPVYERTIENVMSAVLASSDIWRIVDLSEEPLPLVVAVLETLNELGYVEFRDGVFLTEKGRKFAEEYGIGKREDYTCPHCEGKTVDINAFSDLLEQFKEIVKDRPQPKHEFDQAYVTPETTVARIILMHTRGDLENKEVFVLGDDDLTSIALMLSGLPKRIAVLDIDERLIKFIEKTADELGYTNIEIFTFDLRKPLPDYALRKFDTFITDPPETVDAIRAFVGRGIATLKGPGCAGYFGITRRESSLNKWRDIQKLLLNEFNVVITDIIRNFNEYVNWGYEEETRAWKLLPMKVKPRYNWYKSYMFRIQTLEGSKGYEEEIKDEDIYNDEEASTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHW0</accession>
    <name>F0LHW0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cystathionine gamma-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467658.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01385"/>
    <dbReference type="EnsemblBacteria" id="ADT84360">
        <property type="protein sequence ID" value="ADT84360"/>
        <property type="gene ID" value="TERMP_01385"/>
    </dbReference>
    <dbReference type="GeneID" id="10041701"/>
    <dbReference type="KEGG" id="tba:TERMP_01385"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1385"/>
    <dbReference type="eggNOG" id="arCOG00060">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_2"/>
    <dbReference type="OMA" id="LRMERAN"/>
    <dbReference type="OrthoDB" id="55005at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="385" mass="43048" checksum="C25632885E096469" modified="2011-05-03" version="1">MRFSTKAIHVGEEPESMQHGDVVSPIHLSTTFAKRSIKEVEEGYVYSRSGNPTRDALERKLAALENAKYGLAFSSGLAAESTILLALLKKGDHVIAFDDLYGGTKRLFNQVMERFGIEFTYVDARESENVRNAIRENTRMVWLETPTNPLLKLADIRAVAEIAHERDIIVVVDNTFASPYFQNPLDLGADIVLHSVTKYLGGHSDVVGGAVMVNDDEIYERLKFHQNAVGAILSPFDSWLVMRGIKTLAVRMERHEKNAMTIARYLEEHPLVERVYYPGLPSHPQHELAKRQMRGFGGMLSFELKGGLEEAIKFVESLEIFALAESLGGVESLIELPAIMTHASVPKDEREKVGIRDSLIRVSVGIEDVEDLIEDLERGFEAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHW6</accession>
    <name>F0LHW6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467664.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01391"/>
    <dbReference type="EnsemblBacteria" id="ADT84366">
        <property type="protein sequence ID" value="ADT84366"/>
        <property type="gene ID" value="TERMP_01391"/>
    </dbReference>
    <dbReference type="GeneID" id="10041707"/>
    <dbReference type="KEGG" id="tba:TERMP_01391"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1391"/>
    <dbReference type="eggNOG" id="arCOG01307">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_2_2"/>
    <dbReference type="OMA" id="ATIMSKW"/>
    <dbReference type="OrthoDB" id="44676at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Vps4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="144"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="393" mass="44324" checksum="E38447A6D6F50DD3" modified="2011-05-03" version="1">MPVDLSGPLLSEFERAKKEFERAVAAGDMETARRSALRCASILRQLARHVPYNGELYLKKAKKWEDVAGQIERGEYGRKAVVGAEGKSTTQEKDEEDQFREYVLGLISKSRTTWDDIGGLEDVKLLMMETVVIAALKKPAAVQPWRGILLFGPPGTGKTLLASAAAGSLNATFFNVKASSVLSKYFGESSKIISALYEVAREKAPSIVFLDEIDALTTRRSNDTSEATRRMLSTLLTELEGFHGEGNEKLVLTLAATNTPWDLDEAVLSRFPKRIYVPLPDKEATKAIVRIHTEGLDISRLDLDAIAEESVRRLYSGRDIRNLCQEAIWNMIREENKDLHRLAGLPFEELRKRSLRTRPLEMRDFEEAFRKIKSPLTKKDIERYEKWAEEFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHZ8</accession>
    <name>F0LHZ8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467696.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01423"/>
    <dbReference type="EnsemblBacteria" id="ADT84398">
        <property type="protein sequence ID" value="ADT84398"/>
        <property type="gene ID" value="TERMP_01423"/>
    </dbReference>
    <dbReference type="GeneID" id="10041739"/>
    <dbReference type="KEGG" id="tba:TERMP_01423"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1423"/>
    <dbReference type="eggNOG" id="arCOG00247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_0_6_2"/>
    <dbReference type="OMA" id="WSSEVNN"/>
    <dbReference type="OrthoDB" id="92096at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="2">
        <location>
            <begin position="155"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="278" mass="31156" checksum="94E492394498F668" modified="2011-05-03" version="1">MIGWIGLGHIGRAMAERLSEEFEIIVWNRTREKAEGFKNIAESPEEVVSKADVVFLSLYDSKAVQEVAERILKADLRGKIIVDTTTNHFKMVLEFHEMFKNAGAHYLESPVIGSVIPARNGQLTILVSGNEEAYRIVLPYLQRLGKKIFYFKEPGKATKLKLINNFVLGAFMVAIGEAVALGEKAGIEKSELIEILENGAGNSIVLKAKKEKLLTEDFSTHFSVKNLLKDLTYAYELAKSVRKPVFLNAQVKELYSMALSRGIEDEDFSVIYQLLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI19</accession>
    <name>F0LI19_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl12</name>
        <name evidence="6" type="ordered locus">TERMP_00196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466471.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00196"/>
    <dbReference type="EnsemblBacteria" id="ADT83173">
        <property type="protein sequence ID" value="ADT83173"/>
        <property type="gene ID" value="TERMP_00196"/>
    </dbReference>
    <dbReference type="GeneID" id="26135526"/>
    <dbReference type="KEGG" id="tba:TERMP_00196"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.197"/>
    <dbReference type="eggNOG" id="arCOG04287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_2_0_2"/>
    <dbReference type="OMA" id="EYIYAAM"/>
    <dbReference type="OrthoDB" id="128352at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05832">
        <property type="entry name" value="Ribosomal_L12p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_L12/P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022295">
        <property type="entry name" value="Ribosomal_L12_arc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03685">
        <property type="entry name" value="ribo_P1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="104" mass="10698" checksum="51E8E945132469D3" modified="2011-05-03" version="1">MEYVYAALLLHAAGKEITEENLKAVLEAAGVTPDEARIKALVAALEGVNIDEVIEKAAMPVAVAAAPAAAPAPAEEAPAQEEEEEEEEEASEEEALAGLGALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI27</accession>
    <name>F0LI27_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA primase DnaG</fullName>
            <ecNumber evidence="1">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaG</name>
        <name evidence="3" type="ordered locus">TERMP_00204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00204"/>
    <dbReference type="EnsemblBacteria" id="ADT83181">
        <property type="protein sequence ID" value="ADT83181"/>
        <property type="gene ID" value="TERMP_00204"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00204"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.204"/>
    <dbReference type="eggNOG" id="arCOG04281">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034626_0_0_2"/>
    <dbReference type="OMA" id="KYMIVAQ"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00007">
        <property type="entry name" value="DNA_primase_DnaG_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020607">
        <property type="entry name" value="Primase_DnaG_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0271">Exosome</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0639">Primosome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Toprim" evidence="2">
        <location>
            <begin position="174"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="433" mass="48669" checksum="3F5BD1C18D72ADBD" modified="2011-05-03" version="1">MSAKDDFGTTKYVIYAEFEANGVVERPDVVGAIFGQTEGLLGDDLDLRELQKTGRIGRIKVEVHTKAGKTYGTITVPSSLDRVETAILAAALETIDRVGPCEARIKVIKIEDVRATKRKYIIERAKEILETLMEEEIPESQELTEEVKKAVRAKELIEYGPEKLPAGPHVPFSDSIIVVEGRADVLNLLKHGIKNAIAVEGTSVPETIIRLSKERIVTAFTDGDRGGELILKELLQVADIDYVARAPEGKEVEELTKKEIIKALRSKVPAEQVINELFYKGKSFYDLIKEKEREKSEETRKEEVRVEKPPVAVKEEGKEARVEQKREERFIKPIQVPKAAELEKFKEFVEKVKNNSMAILLDEDRNVIAEIPVRDLLSSLNDKEGIHAIIFNGIITQRLIDIVSEKGVKYLIGARKANVVRRPVDLKIITFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI60</accession>
    <name>F0LI60_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466512.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00237"/>
    <dbReference type="EnsemblBacteria" id="ADT83214">
        <property type="protein sequence ID" value="ADT83214"/>
        <property type="gene ID" value="TERMP_00237"/>
    </dbReference>
    <dbReference type="GeneID" id="10040555"/>
    <dbReference type="KEGG" id="tba:TERMP_00237"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.237"/>
    <dbReference type="eggNOG" id="arCOG02295">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1217628_0_0_2"/>
    <dbReference type="OMA" id="VDDKPWR"/>
    <dbReference type="OrthoDB" id="106684at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="224" mass="27080" checksum="74D38DDB9ABA67C1" modified="2011-05-03" version="1">MIVAFDFDGTLVDSYSVIEEAFKRALEKHFRWLPFKEFWAKVLTKIEEYLERPRFGKHGGKIKQPFIFKFKFFRTWFEERAKLTKELDNAKELLKKLKEEGHIVISFSAEDFIDGMKEYRLKVSGFYDLFDDVIIFGRDITLCEAFSLVREKYGDEIFVWVDDKPWRFIGRGDENTEYVWYYFPPTAKYVKEEILAQIPHLHVIRDLWSLFDVIERIKQERKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI68</accession>
    <name>F0LI68_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable transcription termination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusA</name>
        <name evidence="7" type="ordered locus">TERMP_00245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Participates in transcription termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466520.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00245"/>
    <dbReference type="EnsemblBacteria" id="ADT83222">
        <property type="protein sequence ID" value="ADT83222"/>
        <property type="gene ID" value="TERMP_00245"/>
    </dbReference>
    <dbReference type="GeneID" id="26135583"/>
    <dbReference type="KEGG" id="tba:TERMP_00245"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.245"/>
    <dbReference type="eggNOG" id="arCOG01760">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131906_0_0_2"/>
    <dbReference type="OMA" id="TDQIKYI"/>
    <dbReference type="OrthoDB" id="99842at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_A">
        <property type="entry name" value="NusA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010212">
        <property type="entry name" value="NusA_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01952">
        <property type="entry name" value="nusA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="KH" evidence="6">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="145" mass="16630" checksum="7843632F18781B3B" modified="2011-05-03" version="1">MPLKLNTDQIKYIALFESFTGATVLDCIIDQDRNRLIYVIKKGEMGLALGKRGMNVRRIQSMLGKEIDLIEHSENPEEFLRNIYKTMGVRVKKVHITEKKNGKKVALLDVNQRDKPRAIGRGGHNINLVKELMERHHGIEDVVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIB2</accession>
    <name>F0LIB2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01467"/>
    <dbReference type="EnsemblBacteria" id="ADT84442">
        <property type="protein sequence ID" value="ADT84442"/>
        <property type="gene ID" value="TERMP_01467"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01467"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1467"/>
    <dbReference type="eggNOG" id="arCOG00288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059362_3_1_2"/>
    <dbReference type="OMA" id="CAIAAYD"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020051">
        <property type="entry name" value="SagB-type_dehydrogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03605">
        <property type="entry name" value="antibiot_sagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="220" mass="24961" checksum="9445E98BD2C06410" modified="2011-05-03" version="1">MSSLLILFKPYFYSFREYGVKYEGEEVMLPEPELKGEMSVEEAIAKRRSIRYYKDRPLTLKQLSQLLWAAQGITEEKKKFRAAPSAGATYPFEIYVVVGYVEGLKPGVYHYDPFNHSLTLIKEGDYRTELQKAALNQQWVGKAAVDIVLVAFYERTTKYYGERGYRYVYMEAGHIGQNIYLQAVALGLGTVAVGAFHDKEVAKIIGTDGNPIYIFPVGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIE1</accession>
    <name>F0LIE1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane bound hydrogenase MbhC-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01496"/>
    <dbReference type="EnsemblBacteria" id="ADT84471">
        <property type="protein sequence ID" value="ADT84471"/>
        <property type="gene ID" value="TERMP_01496"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01496"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1496"/>
    <dbReference type="eggNOG" id="arCOG03082">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121334_0_6_2"/>
    <dbReference type="OMA" id="YLQMALH"/>
    <dbReference type="OrthoDB" id="105926at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="127" mass="13840" checksum="59C8545E20767E0A" modified="2011-05-03" version="1">MTTIVEYIIYAFLGINITFNLLGSFALHRFPDVYTRLHGATKCTTFGTIFAVLAVIVHAVNQLHITGDPKYLQMALHSLVALIALLLTNPTGAHAIAKAAHLSGVKPVRAVVDAYEVKLKRERGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIE6</accession>
    <name>F0LIE6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="9">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">TERMP_01501</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467774.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01501"/>
    <dbReference type="EnsemblBacteria" id="ADT84476">
        <property type="protein sequence ID" value="ADT84476"/>
        <property type="gene ID" value="TERMP_01501"/>
    </dbReference>
    <dbReference type="GeneID" id="10041817"/>
    <dbReference type="KEGG" id="tba:TERMP_01501"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1501"/>
    <dbReference type="eggNOG" id="arCOG01358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_4_2_2"/>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="OrthoDB" id="18705at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:N6-threonylcarbomyladenosine methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061712">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="129"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="362"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT84476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="424" mass="47976" checksum="9E0DF5C4AEFF062C" modified="2011-05-03" version="1">MRVHIETYGCTRNKADAEIMEALLVNAGYEIVDLDSADYVIVNTCAVKDPTENHMRKRIKELLDAGKKVIVTGCLPHINIEAIDERVSAILGVKSINRITEAIELAERGVKLVDVEQRGIDKLELPRMWKSKVVFVVPISEGCLNACTYCATRFARGILKSYSPEKIVRWVKEALAKGYKEIQLSSEDTGCYGFDIGTNLAELLDELTSIEGEFRIRVGMMNPNHVIKFLDELIDAYKDEKIYKFLHLPVQSGDNEILRKMGRTYTVEDFETIVKAFRKEFPELNLNTDIIVGFPGESEEAFQNTVELIKRVKPDKINVSRFSPRPGTLAARMPDQIVGWRAKERSRYLHRLRLAISYEINQKYVGRELLVLTHGEGKKGGVEGRTMNYKEIILPEAPIGEFVKVKVTKATATYLMGELITSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIG3</accession>
    <name>F0LIG3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00260"/>
    <dbReference type="EnsemblBacteria" id="ADT83237">
        <property type="protein sequence ID" value="ADT83237"/>
        <property type="gene ID" value="TERMP_00260"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00260"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.260"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_2_2_2"/>
    <dbReference type="OMA" id="RISNIEM"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="78" mass="9192" checksum="5F1776A6CDBF29F8" modified="2011-05-03" version="1">MEAFVLIIVKPGNEEKVYNKLKDKPMVKEIYRVYGEYDIVIRVEVSNIAELDKFHDEILRRIGDIEMTETLIASSYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIL4</accession>
    <name>F0LIL4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein pelota homolog</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pelA</name>
        <name evidence="11" type="ordered locus">TERMP_00311</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466586.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00311"/>
    <dbReference type="EnsemblBacteria" id="ADT83288">
        <property type="protein sequence ID" value="ADT83288"/>
        <property type="gene ID" value="TERMP_00311"/>
    </dbReference>
    <dbReference type="GeneID" id="26135652"/>
    <dbReference type="KEGG" id="tba:TERMP_00311"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.311"/>
    <dbReference type="eggNOG" id="arCOG01741">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023334_0_0_2"/>
    <dbReference type="OMA" id="DDLWHLK"/>
    <dbReference type="OrthoDB" id="90096at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01853">
        <property type="entry name" value="PelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023521">
        <property type="entry name" value="Pelota_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="Transl-rel_pelota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PTHR10853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="SSF159065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="356" mass="40595" checksum="00EF3DBB6245FC75" modified="2011-05-03" version="1">MKILDQNPKEGKIKVKAETLDDLWHLYHIIEEGDVVYAKTLRKQSQRSDSLRPEKVQAIPVFLGIRAEKINFHKFANALRITGPIVYASREEVPLGKYHTIAVEENSIITIQKPKWKAHHLERLKQAVEASQRARIMIVVVDDGEADIALVREYGVDIIANIRHNLGGKRYGTNREAEEMKFFHDLAKTIAEIMEREKVDKAIVAGPGFVKENFYRFLQENYPDLAKRVVIEDTSVTGRTGIYEVIRRGTVDKVYHENRVAKEIQLVEKVIEEIAKNGLVAYGIKEVEEAANYGAIETLLVLDELLKGEMREKIEQLMEFVRQMRGEIVIVSSEHEGGEKLKALGGIAALLRYKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIP2</accession>
    <name>F0LIP2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle 19 kDa protein</fullName>
            <shortName evidence="5">SRP19</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">srp19</name>
        <name evidence="6" type="ordered locus">TERMP_01519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SRP19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467792.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01519"/>
    <dbReference type="EnsemblBacteria" id="ADT84494">
        <property type="protein sequence ID" value="ADT84494"/>
        <property type="gene ID" value="TERMP_01519"/>
    </dbReference>
    <dbReference type="GeneID" id="26137030"/>
    <dbReference type="KEGG" id="tba:TERMP_01519"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1519"/>
    <dbReference type="eggNOG" id="arCOG01217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169299_1_0_2"/>
    <dbReference type="OMA" id="FVVWPSE"/>
    <dbReference type="OrthoDB" id="121943at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00305">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022938">
        <property type="entry name" value="SRP19_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SSF69695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="103" mass="11996" checksum="377185D039A5C192" modified="2011-05-03" version="1">MRKFVVWASELDARLSRKYGREIPKNLAVESPKLDEIIEAAKILGMKIVKVEWDKLNPRVSGLDETLRAKGMLVIESKYGKSKSLRLIAQKIREFRKSKRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIV0</accession>
    <name>F0LIV0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01577"/>
    <dbReference type="EnsemblBacteria" id="ADT84552">
        <property type="protein sequence ID" value="ADT84552"/>
        <property type="gene ID" value="TERMP_01577"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01577"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1577"/>
    <dbReference type="eggNOG" id="arCOG10286">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1329532_0_0_2"/>
    <dbReference type="OMA" id="TYMLKRE"/>
    <dbReference type="OrthoDB" id="89446at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="204" mass="23013" checksum="E30868558A15844A" modified="2011-05-03" version="1">MKKILLLFLLLLLPLAVAQEIKIVEFKVDGTMKITVDDVGNAKVNEVWKFTPNLYLQMKQTYPTTYMLKREFENKRSDTEYKNMKIEWDDSNNQIKASYVMLGAAVNKGSYWELNLGEGDLTLSTQNENTIVLTGVQPLFGGQGRLVETITVVLPKDARNVRFENGAIKYELPYKESGKNPIFLGLAVIALIGLVLLNVPLKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIX1</accession>
    <name>F0LIX1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor S</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Transcription elongation factor IIS/RNA polymerase subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_00340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466615.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00340"/>
    <dbReference type="EnsemblBacteria" id="ADT83317">
        <property type="protein sequence ID" value="ADT83317"/>
        <property type="gene ID" value="TERMP_00340"/>
    </dbReference>
    <dbReference type="GeneID" id="26135682"/>
    <dbReference type="KEGG" id="tba:TERMP_00340"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.340"/>
    <dbReference type="eggNOG" id="arCOG00579">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_3_2_2"/>
    <dbReference type="OMA" id="MVKFCPK"/>
    <dbReference type="OrthoDB" id="121393at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="DNA-dir_RNA_pol_M/15kDasu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006288">
        <property type="entry name" value="TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="PTHR11239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="TFIIS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01384">
        <property type="entry name" value="TFS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="66"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="109" mass="12744" checksum="FF9664FF0A9DD49A" modified="2011-05-03" version="1">MVKFCPKCGSIMLPDRKREVFVCRKCGYEEPLNPEAAKAYRLTQKVEHKVEDIPIIEQDLATLPKVKITCPKCGNDEAYWWELQTRAGDEPSTIFYRCTKCGYTWRSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIX8</accession>
    <name>F0LIX8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-oxoglutarate oxidoreductase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466622.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00347"/>
    <dbReference type="EnsemblBacteria" id="ADT83324">
        <property type="protein sequence ID" value="ADT83324"/>
        <property type="gene ID" value="TERMP_00347"/>
    </dbReference>
    <dbReference type="GeneID" id="26135688"/>
    <dbReference type="KEGG" id="tba:TERMP_00347"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.347"/>
    <dbReference type="eggNOG" id="arCOG01606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_1_0_2"/>
    <dbReference type="OMA" id="LNPFPKN"/>
    <dbReference type="OrthoDB" id="41678at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="3">
        <location>
            <begin position="16"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="4">
        <location>
            <begin position="213"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="570" mass="63331" checksum="61C4767C84C116DA" modified="2011-05-03" version="1">MPKFIKDVSIVLGGAAGQGIQTVEETLTRVLKLSGYNVYANKEYMSRVRGGVNTTEIRVSSEKVRAFVRRIDILIPFKRGVLPWVEKRISKNTVVLGEKENVEEEFLENVTFIEVPLSKISKEVGGSLYLNTVAAGVIAGLFHADIKVLEEYLRKRFGGKGEEVVEKNIEAAIRGYNLGRKLCEEKKVEIEVSKDESVKDDILLSGSEAVALGALAGGMNFLSFYPMSPSTGVAVFLAQHAEDFEIIVEQVEDEISAINMALGAWFAGARAMVTTSGGGFALMTEAISLAGMAENPVVVHLAQRPGPATGLPTRTMQGDLNLALHAGHGEFPRIILAPGTIEEAFYLTAEAFNLADKYQVPVIIMTDEYLVDTYYNIPDIEFDRIKVEKYVVEAEEDYKRYKLTEDGISPRAIPGYGKGVVVANGNEHDEYGDITEDEELSRIMQEKRAIRKLETIKKSAKLPKLIGDENARYLVIGWGSTFHVIREALEQLNIDDIAFLHFSWVYPLREDIREMFDGKVIIDIEGNVTGQFAQLLKRELGVEVDYKILKYDGRPFSVEEICDALKGVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIY1</accession>
    <name>F0LIY1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466625.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00350"/>
    <dbReference type="EnsemblBacteria" id="ADT83327">
        <property type="protein sequence ID" value="ADT83327"/>
        <property type="gene ID" value="TERMP_00350"/>
    </dbReference>
    <dbReference type="GeneID" id="10040668"/>
    <dbReference type="KEGG" id="tba:TERMP_00350"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.350"/>
    <dbReference type="eggNOG" id="arCOG00509">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017490_1_0_2"/>
    <dbReference type="OMA" id="VPWLHWP"/>
    <dbReference type="OrthoDB" id="72715at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="265"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="410" mass="47090" checksum="F6E78AE552CBBA06" modified="2011-05-03" version="1">MPKVWIEKILDKPELYLLRVDDNQIKYFEATWEIPEGITYNAYLLKLENAVVLFDAWKKDYTKEFIEALSKLVDPKEITHIVVHHTEPDHSGALSEVLRLNCYRAQIIGTSFAKRLLEAFYGSKAVENFYTIKDGEEMKIGGKTFRFITVPWLHWPDTMITYIVEEGLMFSCDAGGGYSIPKTIDDSDEEVVQEYLPYVTKYIVTVIGHYHKYIVQNIEKLKKLGIIEKTKMILPGHGLIWRKNPKRIFEHYEAVGAGVPKRGKVLVIYDSMYGFVEKAIEIALDELKKHGYIPVVYRFTDKEAPAVSDILGEVPDSEALIIGASTYEANIHPRVRYVLYEIVDKANYEKPVLILGAYGWAGVAGREIETMIMRSKFDHVDTIEARGNATEEDEERIRESVRKLIQKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ31</accession>
    <name>F0LJ31_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466675.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00400"/>
    <dbReference type="EnsemblBacteria" id="ADT83377">
        <property type="protein sequence ID" value="ADT83377"/>
        <property type="gene ID" value="TERMP_00400"/>
    </dbReference>
    <dbReference type="GeneID" id="10040718"/>
    <dbReference type="KEGG" id="tba:TERMP_00400"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.400"/>
    <dbReference type="eggNOG" id="arCOG10058">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112309_0_0_2"/>
    <dbReference type="OMA" id="PECYTLE"/>
    <dbReference type="OrthoDB" id="112221at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="213" mass="24902" checksum="FD37132BB735FA71" modified="2011-05-03" version="1">MPVLGKIKGMFQVMTEGKIFKYASIRCEVLSECMRRMEDYFQFRRMHYTRLIDPDPYLLETMADSLYERGQFLGVVELKAELSRAFYFLDSDVPIELKDIPGLEFTLTFRVRKKEGLQELLGIIGKEKAGRIRHKHRSTLNFLISLLSGTVFSSVMEFRSYWSNLLVTIFFALILYLVLDYPFSLLYFKGVEVMSTGEVHTKVFVVKVRMGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ42</accession>
    <name>F0LJ42_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-polyprenyl-4-hydroxybenzoate carboxy-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466686.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00411"/>
    <dbReference type="EnsemblBacteria" id="ADT83388">
        <property type="protein sequence ID" value="ADT83388"/>
        <property type="gene ID" value="TERMP_00411"/>
    </dbReference>
    <dbReference type="GeneID" id="10040729"/>
    <dbReference type="KEGG" id="tba:TERMP_00411"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.411"/>
    <dbReference type="eggNOG" id="arCOG01671">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023348_5_1_2"/>
    <dbReference type="OMA" id="TEGGCCW"/>
    <dbReference type="OrthoDB" id="35356at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="422" mass="47960" checksum="BBFA6600AFBAB9CD" modified="2011-05-03" version="1">MLREIIEKFEDEVVTIEKPISKSLEITKYLLKYKTKPVLFKDVDGWEVVGNLWSTRERIAKYLGIKKEDILHVMECAMDNLHDYKLIEKAEFMENITKDFSLKELPIPKYYPKDGGEYFTSAVVVAKDENGFVNMSFHRMMVIDDKRTAIRIVPRHLYAMWKEKAERGEELDVRIIVGNPIYVLLAAATSVEYGKSELNIASAIKEKTLGSPLEVVNVNGIEVPAESELVFEAKILPELTDEGPFVDITGTYDHIRKQPVVVFEKMYHVDNPIFHVLLPGGYEHYMLMGLPKEPQIYKSVKRVVPKVHGVRLTEGGCMWLHAVVSITKHHDGDGKNAILAAFAGHPSLKHVVVVDEDVNIYDDREVEWAIATRFQADRDLVVIPNARGSSLDPSADKSLTAKWGIDATKPLDKKEEFERAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ83</accession>
    <name>F0LJ83_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467903.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01630"/>
    <dbReference type="EnsemblBacteria" id="ADT84605">
        <property type="protein sequence ID" value="ADT84605"/>
        <property type="gene ID" value="TERMP_01630"/>
    </dbReference>
    <dbReference type="GeneID" id="26137172"/>
    <dbReference type="KEGG" id="tba:TERMP_01630"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1630"/>
    <dbReference type="eggNOG" id="arCOG00132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025894_0_2_2"/>
    <dbReference type="OMA" id="LMNIVWP"/>
    <dbReference type="OrthoDB" id="32618at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="390" mass="43554" checksum="D59F78B589C8B4C0" modified="2011-05-03" version="1">MLQKFNRDAKILIALNAVGQLFLQFSFFIIPFYLRALGYSMSDMGVFFSLRTFVGALFFLFAGQISLKIGYKKSLLLGAVLGFTGRILQVTALNYYVLLLGFLLVGVNMGIRQPNFSALLSEEVGDELRHHAFSISFGLGTIFNAVGVLLAGFMPNFLENAFGITTQLAYRLVLAFSFLQFLITIPALLIIKDVPVENPKIRWRKELIIKILKFSVPSAIIGLGAGITIPYMQLYFDMRFGVTLAAISGVFFFQQLVMGLGSFILPKLVDRIGPVKTITLFQSSAALLFAVFPSINIFTLAAFFYIIRSILMNIVWPINDSFMLGFFSTEEKATAVGIRRAFSTFMRGVGNYIGGFLFGISLSYPFYTTATLYIIATLTFYFFFAKYNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ89</accession>
    <name>F0LJ89_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01636"/>
    <dbReference type="EnsemblBacteria" id="ADT84611">
        <property type="protein sequence ID" value="ADT84611"/>
        <property type="gene ID" value="TERMP_01636"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01636"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1636"/>
    <dbReference type="eggNOG" id="arCOG00777">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124322_0_1_2"/>
    <dbReference type="OMA" id="HCYVLEK"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="39"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="128" mass="14239" checksum="EF40404ACBB9A5FD" modified="2011-05-03" version="1">MQRTHNLTSKRLVGEPVKITEGYAEVKLKTVDEMKVDEHGLVHGGFTFGLADYAAMLAVNEPTVVLGKAEVKFTKPVKVGDELLAKAKVVEDLGKKKVVHVEVFNQGNEKVLEGEFYCYVLEKHVLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ96</accession>
    <name>F0LJ96_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467916.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01643"/>
    <dbReference type="EnsemblBacteria" id="ADT84618">
        <property type="protein sequence ID" value="ADT84618"/>
        <property type="gene ID" value="TERMP_01643"/>
    </dbReference>
    <dbReference type="GeneID" id="10041959"/>
    <dbReference type="KEGG" id="tba:TERMP_01643"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1643"/>
    <dbReference type="eggNOG" id="arCOG05720">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1922896_0_0_2"/>
    <dbReference type="OrthoDB" id="100844at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="131" mass="14984" checksum="D0111355D482CE11" modified="2011-05-03" version="1">MEKSDDILSLYLDMLSSGFYIGNVRGSITAVTEEGEFPLISPVPTTTFDIFCSENSLILFGFWKHGEEAEYGYLKIPLSRIEMIGEIDDELILYVFSEKRTQDSIGFVRLNLYPEPIIKEKLLKVIEFGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ99</accession>
    <name>F0LJ99_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467919.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01646"/>
    <dbReference type="EnsemblBacteria" id="ADT84621">
        <property type="protein sequence ID" value="ADT84621"/>
        <property type="gene ID" value="TERMP_01646"/>
    </dbReference>
    <dbReference type="GeneID" id="26137156"/>
    <dbReference type="KEGG" id="tba:TERMP_01646"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1646"/>
    <dbReference type="eggNOG" id="arCOG05796">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191936_0_0_2"/>
    <dbReference type="OMA" id="AHGKYFY"/>
    <dbReference type="OrthoDB" id="127922at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="85" mass="10202" checksum="6F47B76B2F153D64" modified="2011-05-03" version="1">MDFELFMERYGYKLLLGLMALVVIVVVGIPILGYIYFLRRYSWEIGGLMLIIVVVYAFSVRRKVMDAYAQAHGKYFYDDKWYKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJD2</accession>
    <name>F0LJD2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroB</name>
        <name evidence="10" type="ordered locus">TERMP_00421</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466696.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00421"/>
    <dbReference type="EnsemblBacteria" id="ADT83398">
        <property type="protein sequence ID" value="ADT83398"/>
        <property type="gene ID" value="TERMP_00421"/>
    </dbReference>
    <dbReference type="GeneID" id="10040739"/>
    <dbReference type="KEGG" id="tba:TERMP_00421"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.421"/>
    <dbReference type="eggNOG" id="arCOG00983">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_0_1_2"/>
    <dbReference type="OMA" id="YGVIWDA"/>
    <dbReference type="OrthoDB" id="45841at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="50"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="54"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="88"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="332" mass="37101" checksum="C874E17C34426948" modified="2011-05-03" version="1">MEIIIKKGSIKKLKSIVDELSPYKTAVITNTTLEKLWLDKILDQINAVPIVIPDGEEFKSLETAQQIWKKLIEISFTRRSLIIGLGGGVMTDLAAFAASTFMRGTYLGLIPTTLLAQVDAAIGGKTGVNFEGKNIIGTFYLPNFVLIDPETLKTLPEVEIVNGFGEVVKYGILDSRVYKKLKSFRKIDEELIRECVNVKLRIVEEDLRESGKRRILNLGHTAGHAVEKASNYRVKHGFAVAIGLMASALIAEKVNGFDSGKVEELLDKFSLPKRHSFEPKELLEAMKIDKKAWYGRLVFILPEEIGKVTIREVEEKIVLAVLEAMKNDSRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJK5</accession>
    <name>F0LJK5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00494"/>
    <dbReference type="EnsemblBacteria" id="ADT83471">
        <property type="protein sequence ID" value="ADT83471"/>
        <property type="gene ID" value="TERMP_00494"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00494"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.494"/>
    <dbReference type="eggNOG" id="arCOG05832">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1122675_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="212" mass="24985" checksum="0E995CFCDBA88107" modified="2011-05-03" version="1">MGIALRFLFETGISSERLPRKKSKWWNVAEFITLFAIVVAVYLLLTAKPRYLPRGEAPIIRYPKWIMSFGLNQTVMIYYKPLPLYAYALPLIIAALLVLTAVKRRKKRIIIMGEPHKFNPQMTFDTIEGTPEERIIKMYKNVVAGLILKGYPYQKSWTHWEHEEKLRDIFEDLEDLHALTRIFEKAKYAKRLSSKDIDIAKKSYDNLMKFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJM2</accession>
    <name>F0LJM2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase electron transfer subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="4">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="F0LJM2"/>
    <dbReference type="STRING" id="391623.TERMP_01689"/>
    <dbReference type="EnsemblBacteria" id="ADT84664">
        <property type="protein sequence ID" value="ADT84664"/>
        <property type="gene ID" value="TERMP_01689"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01689"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1688"/>
    <dbReference type="eggNOG" id="arCOG02199">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_1_1_2"/>
    <dbReference type="OMA" id="RYMKCGI"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="246" mass="27987" checksum="047C88698ADAF16E" modified="2011-05-03" version="1">MRVELTEVWEEAKNIKAFRFNRKLNFVPGQFIMVWLPGFGEKPFSLADKDLILVKRVGAFTSKMFELKEGNYIWIRGPYGKGFEPEGENIGVIAGGIGIPPLYALVKHYREHFERITLIYGSKSRYEFALLDIENYVDEIILTTDDGSLGVKGFPTDVLAERKDEFDYVYTCGPEVMMAKVLEIMNFKNVQVSAERYMKCGIGVCGSCALGEYLVCKDGPVFYGEQLKNTELGKFRRLPDGRIARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJR4</accession>
    <name>F0LJR4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468004.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01731"/>
    <dbReference type="EnsemblBacteria" id="ADT84706">
        <property type="protein sequence ID" value="ADT84706"/>
        <property type="gene ID" value="TERMP_01731"/>
    </dbReference>
    <dbReference type="GeneID" id="10042047"/>
    <dbReference type="KEGG" id="tba:TERMP_01731"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1730"/>
    <dbReference type="eggNOG" id="arCOG00001">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_3_2"/>
    <dbReference type="OMA" id="KDLIRGH"/>
    <dbReference type="OrthoDB" id="117084at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="123" mass="14244" checksum="E4AF8026C79F7FF5" modified="2011-05-03" version="1">MFGDPKEKALKKLRRELRAGTYSFIILSLLENKGDMHGYAIRKEFEKLSSGKIVPSEGTLYDLLKSLERYKLIEGFWAEVGGRARKYYRITSLGEKVLEELKKEIESVSRMMKKLGGDEYGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJT6</accession>
    <name>F0LJT6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466771.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00496"/>
    <dbReference type="EnsemblBacteria" id="ADT83473">
        <property type="protein sequence ID" value="ADT83473"/>
        <property type="gene ID" value="TERMP_00496"/>
    </dbReference>
    <dbReference type="GeneID" id="10040814"/>
    <dbReference type="KEGG" id="tba:TERMP_00496"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.496"/>
    <dbReference type="eggNOG" id="arCOG03351">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1821110_0_0_2"/>
    <dbReference type="OMA" id="EYHYYKL"/>
    <dbReference type="OrthoDB" id="106282at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_7" evidence="1">
        <location>
            <begin position="85"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="129" mass="15076" checksum="4FDE76C892378F25" modified="2011-05-03" version="1">MRVEITARNNEELLRKIDELLNENVREVYINLRPTKEILVRILENAPNVKLIGCPPSLYPKVSKRVIRALRQMGIEVVPIKKSRGRPRKYDEAVLLRIRELMTQGKSPKEISRELGIPLRTVYYMLNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJU0</accession>
    <name>F0LJU0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466775.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00500"/>
    <dbReference type="EnsemblBacteria" id="ADT83477">
        <property type="protein sequence ID" value="ADT83477"/>
        <property type="gene ID" value="TERMP_00500"/>
    </dbReference>
    <dbReference type="GeneID" id="10040818"/>
    <dbReference type="KEGG" id="tba:TERMP_00500"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.500"/>
    <dbReference type="eggNOG" id="arCOG04150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064992_3_0_2"/>
    <dbReference type="OMA" id="DPLAVWK"/>
    <dbReference type="OrthoDB" id="80501at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019964">
        <property type="entry name" value="KH_domain_protein_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039912">
        <property type="entry name" value="PNO1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="PTHR12826:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03665">
        <property type="entry name" value="arCOG04150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="35"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="126"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="222" mass="25190" checksum="2EE42C31D48FBB25" modified="2011-05-03" version="1">MRDEFDKLLKKYEYVDKEGERRSEFEESIDYESLGEQEEFVRIPKERIGVLIGKKGSTKKKIEEITKTKIEVDSETGEVFISSTEKTDDPLAVWKARDVVMAIGRGFSPERAFRLFNEGEVLEIINLSDIIIGNEKNALPRIRGRIIGRKGRTREIIEEMSGADISVYGKTVAIIGNPIQVEIAKTAIEKLAKGSPHGTVYKYLERRKKDLELEGGVYYGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJU1</accession>
    <name>F0LJU1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TERMP_00501</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466776.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00501"/>
    <dbReference type="EnsemblBacteria" id="ADT83478">
        <property type="protein sequence ID" value="ADT83478"/>
        <property type="gene ID" value="TERMP_00501"/>
    </dbReference>
    <dbReference type="GeneID" id="10040819"/>
    <dbReference type="KEGG" id="tba:TERMP_00501"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.501"/>
    <dbReference type="eggNOG" id="arCOG01180">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_3_3_2"/>
    <dbReference type="OMA" id="EIRCAKV"/>
    <dbReference type="OrthoDB" id="44076at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="50"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT83478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="256" mass="30398" checksum="58E106AE9CDBEDA9" modified="2011-05-03" version="1">MERFDREIAEILGLDERREKDSELFKVFSEVFDKTTVETLSYFHRRGKIEQLLGVISTGKEANVFMGTDSKGNKIAVKIYRTYTTEFRRIWEYLAADPRVGYLPKDIRKLVFVWTRREFKNLQRAMKYAVRAPEPIAFRNNILIMEFIGDEVPAPRLKDVEKVLEKRDFEELYEFSMSAIERLWKRGDMVHGDLSEYNILIWEKPVIIDWSQATVKRNRMSLTLLYRDLRNIINYFGRKGVAVDDLEEKFKELTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJU4</accession>
    <name>F0LJU4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466779.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00504"/>
    <dbReference type="EnsemblBacteria" id="ADT83481">
        <property type="protein sequence ID" value="ADT83481"/>
        <property type="gene ID" value="TERMP_00504"/>
    </dbReference>
    <dbReference type="GeneID" id="10040822"/>
    <dbReference type="KEGG" id="tba:TERMP_00504"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.504"/>
    <dbReference type="eggNOG" id="arCOG03396">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_506827_0_0_2"/>
    <dbReference type="OMA" id="RGCSEDY"/>
    <dbReference type="OrthoDB" id="45295at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="532" mass="61252" checksum="F2103D498AF79849" modified="2011-05-03" version="1">MKKLSVVMIILLFLPSATAFSFEEAKTEVIQKLEAQVNFVENAELNYAIYIRFLEIIAVTRSGIPNEKLIQNYAEWLKSLQEDDGSFPPIITFDVSGVPSCDAYYYAERPKGFEGFPSCLYGFSFKKCPEYSYITTCSRAASTALILYALLDAGEPRNSPVIKKGVQYLLKTMKNGTYWTYVYTVSSSKVGVSSCKEAEKVWGFKEKPSLVATAYAVALLHRLGYNVSKSLQWLNSNLKPENLINKDYLTYLLENETPKWEYSFPFYQLGFPSVHFYHREPFESLVVPLVLIKEERLEINQSAVRFMVSILNKTRISFAGDYTLYISTDLFWNSKENYSLSVLFKGTNLSQITENGTFYYLLSRSLKFKALEKNFTISGSLNFTVPEEVSWEPEVNVFLFKRLTNRSYMRVDCAEVEKCGRGCYNFKLYPHYDWWSDSIRPSATALLWYYLAGETRAIDEFLRNYSSPKCESELAEDYQNRGCSEDYALLLLLMDVRSGSFKEYGKPRIKLVGGIFVFVVLVLLVRLYLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJU8</accession>
    <name>F0LJU8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00508"/>
    <dbReference type="EnsemblBacteria" id="ADT83485">
        <property type="protein sequence ID" value="ADT83485"/>
        <property type="gene ID" value="TERMP_00508"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00508"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.508"/>
    <dbReference type="eggNOG" id="arCOG00020">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035788_0_0_2"/>
    <dbReference type="OMA" id="AWIEIPA"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019293">
        <property type="entry name" value="ThiN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10120">
        <property type="entry name" value="ThiP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="1">
        <location>
            <begin position="17"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="449" mass="48941" checksum="2C83BF58ECAC9B96" modified="2011-05-03" version="1">MDDRKYVKTALTIAGSDSGGGAGIEADLKTFSAFGVHGLVAITSVTAQNTQEVRAIYDVSPEVVAKQIEAVADDIGVDAAKTGMLSSAEIIKAVAKTMEKYEFPLVVDPVMIAKSGAPLLREDAVDALLKYVIPLATLVTPNKPEAEKLSGIKIETLEDAKKAAKIIVEELGAKAAIVKGGHLNLSEAVDVLYYGGEFREYRAPFVEGCTHGTGCSFSAAITANLAKGKDLEEAIKVAKEFITMGIFYGARIGKGHCPVNQNAWIEIPAEKWRVYESLVKAVRELEKIGDRTLPHVPETGMDFVYALSRLYARTPKDVAGSKIVRVGNTVKAVGSVEFGASNYLVSAVLKFMELYPEIRSALNLRYSEELIKKAQKNGFRVSFYDRRKELEKIKVKEEATIPRDIETAIKMLSEKPDIICHLGNWGGEALMLIFGESPEDVLRKVKIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJW9</accession>
    <name>F0LJW9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Archaeal ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466804.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00529"/>
    <dbReference type="EnsemblBacteria" id="ADT83506">
        <property type="protein sequence ID" value="ADT83506"/>
        <property type="gene ID" value="TERMP_00529"/>
    </dbReference>
    <dbReference type="GeneID" id="10040847"/>
    <dbReference type="KEGG" id="tba:TERMP_00529"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.529"/>
    <dbReference type="eggNOG" id="arCOG03166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041137_3_0_2"/>
    <dbReference type="OMA" id="YNEDKFH"/>
    <dbReference type="OrthoDB" id="21452at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="300"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="443" mass="52583" checksum="D0A5D532084E94C6" modified="2011-05-03" version="1">MKHFVDRKNELRAIREKLMSRKFELIVIYGRRRVGKTRLVLEAVKDFPHIYYLAVESDNLRHFRKTAERIAPEVRYTREDWESLLHALKGKVIIIDEFPNMIKEDPKVVSIFQRAVDLDLSNSNTKLILLGSSVSMMTEKVLSYKSPLYGRRTGSMKLKPMEFFTLREFFPGISWKELIEIYGLTDGIPFYIIQVKLPFWEWLEKELLNPVSFFRDEVDFLLRYEFTETRTYRRILEAIALGKTTPKEIKDFTGMRHSDITPYLRNLIETDLVVREVPVTEKPASKKGRYYVADNFLAFWFRYIYPNLSRIEAGTFDIAEIREDYSRYLGWVFEKVARQFLVRLNKAGRLPFRFTKIGKWWHKSEEIDLVALNEREKKVLFVEVKWKDLREREAKGVLRNLERKSKLVGLEDWEKAYGMIARNIGGKEDVRGSGYFAWDLGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJX1</accession>
    <name>F0LJX1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00531"/>
    <dbReference type="EnsemblBacteria" id="ADT83508">
        <property type="protein sequence ID" value="ADT83508"/>
        <property type="gene ID" value="TERMP_00531"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00531"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.532"/>
    <dbReference type="HOGENOM" id="CLU_3302926_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="39" mass="4624" checksum="8705AF7500993DFA" modified="2011-05-03" version="1">MLFVNYPALPDRDFPPDKLNKKLIKQLHSKIMKLIEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJX9</accession>
    <name>F0LJX9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfhydrogenase II subunit b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466814.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00539"/>
    <dbReference type="EnsemblBacteria" id="ADT83516">
        <property type="protein sequence ID" value="ADT83516"/>
        <property type="gene ID" value="TERMP_00539"/>
    </dbReference>
    <dbReference type="GeneID" id="10040857"/>
    <dbReference type="KEGG" id="tba:TERMP_00539"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.540"/>
    <dbReference type="eggNOG" id="arCOG05128">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046702_0_0_2"/>
    <dbReference type="OMA" id="THKLGTW"/>
    <dbReference type="OrthoDB" id="34322at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17179">
        <property type="entry name" value="Fer4_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="367" mass="43290" checksum="C780C7297790BD86" modified="2011-05-03" version="1">MRYVKLPQENVYEFLERLKNFGKLYAPVKISEKFYDFREIDDVRKIEFHYNRTIMPPKKFFFLPRETMFKFSISKAEYEEVVENVEPFVIFGLHACDIFGLKIMDTIYLDEFPDKYYKIRREKGIIIGISCMPDEYCFCNLRETDFADDGFDLFLHELPDGWLVRVGTPTGHRIVDKNIKLFEEVTTQDICNFRDFEKKRHQSFRYHEDWGNLRYLLELEMEHPMWDEQSELCLGCGNCNLTCPTCRCYDVQDIPNLDGDTGVRIRRWDSCQLRSHGLVAGGHNFRPTKKSRFMNRYLCKNAYNEKLGISYCVGCGRCTYFCPAGISFVRNLRTILGFEEKSCPPEMSEEIPKRGFAYASNIRGEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK37</accession>
    <name>F0LK37_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential transporter for phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01774"/>
    <dbReference type="EnsemblBacteria" id="ADT84749">
        <property type="protein sequence ID" value="ADT84749"/>
        <property type="gene ID" value="TERMP_01774"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01774"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1773"/>
    <dbReference type="eggNOG" id="arCOG02267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_3_3_2"/>
    <dbReference type="OMA" id="VWWIVAP"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="407" mass="42822" checksum="C7793C104FF2513A" modified="2011-05-03" version="1">MIEALTDPWLFITIAVGLFMAWTIGANDAANSMSTAVGAGAITPKQAVIIAGVLEFTGAYFFGKSVTETIRKGIIDPSKITEPSVLIYGSIAALLAAALWLLMATKFGLPVSTTHSIIGGIVGYGIVYAGIGIVNWGKMAQVIASWILSPIFGAIMAFMVFKAISKTILQSENPVKSAKNYSPVWIGLAFVVIGSMFYIKVLHGKSLLIAVIKFGIPAGFAAFLVSFMLLRRNFKTADPYLGAESIFKKVQVLTSAYVALSHGANDVANAIGPVAAVYAVATMGLAGMRVPVPRWILAMGGLGIAVGVATYGYKVMETVGKKITELTNTRGFSIDFSAATVVLIASWLGLPISTTHTVVGAVIGVGLARGVKAINKDIVKNIIISWFVTVPIAAIISGIIFKILMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK61</accession>
    <name>F0LK61_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetate--CoA ligase (ADP-forming)</fullName>
            <ecNumber evidence="2">6.2.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15081"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.2.1.13" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468069.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01798"/>
    <dbReference type="EnsemblBacteria" id="ADT84773">
        <property type="protein sequence ID" value="ADT84773"/>
        <property type="gene ID" value="TERMP_01798"/>
    </dbReference>
    <dbReference type="GeneID" id="10042114"/>
    <dbReference type="KEGG" id="tba:TERMP_01798"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1797"/>
    <dbReference type="eggNOG" id="arCOG01340">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007415_2_3_2"/>
    <dbReference type="OMA" id="CVPPIFI"/>
    <dbReference type="OrthoDB" id="15044at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="443" mass="48217" checksum="2F76ACB433738065" modified="2011-05-03" version="1">MDLDFFFYPSSVAIFGSFRKGAIAYEILRNIAEGGFEGKITPINPKGGEVEVSGKRFEIKKRLDEKTDVAIIAIPAKLVPGLIEEIGDKIRGAVVISAGFSEIGNMELERELVEKAREKGVRIIGPNCAGIFGVHGKFFGSFEVRVKKGGLALISQSGAFGGAALAMGNEEGIGFSAFVSYGNATDLTESDFLRYFADDRNTKAIALYIEGVKDGRKFIDALKYATPKKPVIILKAGKSRSGSRAAQSHTGSLAGSYEIYKAAFNQFGAIEVEEMEELFDAAKVFEMYDKAGRRIAIITNSGGPGVLATDKAESLGLEIAKLSEKTIKALREFLPPQCSVKNPIDLIADADYERYKRTIEIVGKDENVDALLVICVPPIFIPSEEIAKAIIDAKCDKPIIVNFMAGKLVRDGVKLLAEKGIKNFQTPERAAKAFYWLSLREKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKC1</accession>
    <name>F0LKC1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466877.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00602"/>
    <dbReference type="EnsemblBacteria" id="ADT83579">
        <property type="protein sequence ID" value="ADT83579"/>
        <property type="gene ID" value="TERMP_00602"/>
    </dbReference>
    <dbReference type="GeneID" id="10040920"/>
    <dbReference type="KEGG" id="tba:TERMP_00602"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.603"/>
    <dbReference type="eggNOG" id="arCOG00278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1084240_0_0_2"/>
    <dbReference type="OMA" id="LFWQLGH"/>
    <dbReference type="OrthoDB" id="83362at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="149"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="279" mass="30684" checksum="4494800048C13124" modified="2011-05-03" version="1">MNQEAKGTLFAFIALILVGIEPVVIKSNPVNPLSFAAFSALFASLILWVMILPSGKWKELKESPEHLHKAFLVGLFGTALAYIAYSYGARMSTAINASLITRSEVLYSFVLSYLFLRERITKKQLVLSLIILLGIVLVITQGRFIEPKRGDVLLLLTPLFWQIGHTIAKQLKYSPYLIATLRNTFGGLILLVLALSLDLEFTKLAVVEGVIIALTQVLWYSAIRLINLSKATAIITPAPAVAIGLSILLGENFTVYHAVGFILIMIGTLGVSKIKSERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKD1</accession>
    <name>F0LKD1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoglutarate oxidoreductase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466887.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00612"/>
    <dbReference type="EnsemblBacteria" id="ADT83589">
        <property type="protein sequence ID" value="ADT83589"/>
        <property type="gene ID" value="TERMP_00612"/>
    </dbReference>
    <dbReference type="GeneID" id="10040930"/>
    <dbReference type="KEGG" id="tba:TERMP_00612"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.614"/>
    <dbReference type="eggNOG" id="arCOG01599">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_2_0_2"/>
    <dbReference type="OMA" id="SAWIASP"/>
    <dbReference type="OrthoDB" id="43666at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="57"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="287" mass="31431" checksum="3007E36D0A7A8ACA" modified="2011-05-03" version="1">MAKEIYTKYKMAKYLRKEALPTALCPGCGGGTVLNAFANAIDQLKIDPRDLVVVSGIGCSAWIASPYFLADTLHTTHGRAIAFATGVKVGLPDKKVVVISGDGDLAGIGGNHLIHAARRNIDITVILVNNFIYGMTGGQVAPTTPFGAKTTTTPYRNIEHPLNIAEVVAEAGASYVARWTTAHVYQLIESIKRALQVKGFSLVEVISQCPVQFGRRNKMKEPAEMLRWFLRNSIPISKAKNMSKEELEGKFVIGEFVNRQRPEFTEELNKLIDEVAEHFGLGDEDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKH3</accession>
    <name>F0LKH3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Fructose-1,6-bisphosphate aldolase/phosphatase</fullName>
            <shortName evidence="15">FBP A/P</shortName>
            <shortName evidence="15">FBP aldolase/phosphatase</shortName>
            <ecNumber evidence="6 15">3.1.3.11</ecNumber>
            <ecNumber evidence="15">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">fbp</name>
        <name evidence="16" type="ordered locus">TERMP_01832</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">Homooctamer; dimer of tetramers.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the FBP aldolase/phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="6 15"/>
    <dbReference type="EC" id="4.1.2.13" evidence="15"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468103.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01832"/>
    <dbReference type="EnsemblBacteria" id="ADT84807">
        <property type="protein sequence ID" value="ADT84807"/>
        <property type="gene ID" value="TERMP_01832"/>
    </dbReference>
    <dbReference type="GeneID" id="10042148"/>
    <dbReference type="KEGG" id="tba:TERMP_01832"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1831"/>
    <dbReference type="eggNOG" id="arCOG04180">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041630_0_0_2"/>
    <dbReference type="OMA" id="YMRRHGP"/>
    <dbReference type="OrthoDB" id="21175at2157"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02067">
        <property type="entry name" value="FBP_aldolase_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002803">
        <property type="entry name" value="FBPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036076">
        <property type="entry name" value="FBPase_V_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38341">
        <property type="entry name" value="PTHR38341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01950">
        <property type="entry name" value="FBPase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015647">
        <property type="entry name" value="FBPtase_archl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111249">
        <property type="entry name" value="SSF111249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 15" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="FBP binding" evidence="15">
        <location>
            <begin position="107"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="FBP binding; shared with dimeric partner" evidence="15">
        <location>
            <begin position="250"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for FBP phosphatase activity" evidence="15">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor; for FBP aldolase activity" evidence="15">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DHAP; for FBP aldolase activity" evidence="15">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADT84807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="374" mass="41824" checksum="7AB4EF3D0E0E2D09" modified="2011-05-03" version="1">MAVGEKITISVIKADIGGWPGHHKVHPALIEKAREILSKAKEEGTIIDFHVTYCGDDLQLIMTHKKGTDSPDIHGLAWETFKEATKTAKELGLYGAGQDLLKDAFSGNIRGMGPGAAEMEITIRKSEPIVTFHMDKTEPGAFNLPIFRMFADPFNTAGLVIDPNMHMGFRFEIWDIREHKRVIMNSPEEMYDILALIGAKSRYVIKRVFPKEGHKLPKDEPVAVVSTEKLYEIAGEYVGKDDPVAIVRAQSGLPALGEVLEPFAFPHLVSGWMRGSHNGPIMPVPLKYATPSRFDGPPRAVALGWQISPEGKLIGPVDLFDDPAFDWARQKALEITEYMRRHGPFEPHRLPLEEMEYTTLPGVLEKLKDRFEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKL8</accession>
    <name>F0LKL8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease NucS</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nucS</name>
        <name evidence="4" type="ordered locus">TERMP_01877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NucS endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01877"/>
    <dbReference type="EnsemblBacteria" id="ADT84852">
        <property type="protein sequence ID" value="ADT84852"/>
        <property type="gene ID" value="TERMP_01877"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01877"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1876"/>
    <dbReference type="eggNOG" id="arCOG01304">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069350_1_0_2"/>
    <dbReference type="OMA" id="RCSVDYA"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="251" mass="28647" checksum="0CA7D0931324B567" modified="2011-05-03" version="1">MEAKVEPSHEEIIEILDKALSVEAIITLFAYCRVFYEGRAKSELGPGDRVIIIKPDGSFLIHQKNKREPVNWQPPGSVVSIVLEDGRIMLRSVRRKPKETLEVELIKTYLVSYFQAEDYEELTLTGSEAEMADLIFENPSLIEEGFKPLFKEKPIKHGIVDVLGKDKHGNLVVLELKRRRADLHAVSQLKRYVDSLREEHKNVRGILVAPSLTAGAKKLLEKEGLEFKKLNPPKREKRKKGKQKTLDFLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKM1</accession>
    <name>F0LKM1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="3">MTA phosphorylase</shortName>
            <shortName evidence="3">MTAP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mtnP</name>
        <name evidence="5" type="ordered locus">TERMP_01880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468151.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01880"/>
    <dbReference type="EnsemblBacteria" id="ADT84855">
        <property type="protein sequence ID" value="ADT84855"/>
        <property type="gene ID" value="TERMP_01880"/>
    </dbReference>
    <dbReference type="GeneID" id="10042196"/>
    <dbReference type="KEGG" id="tba:TERMP_01880"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1879"/>
    <dbReference type="eggNOG" id="arCOG01327">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_0_2_2"/>
    <dbReference type="OMA" id="ADPFCPE"/>
    <dbReference type="OrthoDB" id="63298at2157"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="4">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="3">
        <location>
            <begin position="50"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="3">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="204"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="257" mass="29075" checksum="0DDC3B4BE6516187" modified="2011-05-03" version="1">MPKIGIIGGSGVYGVFEPKETIKVHTPYGRPSAPVEIGEIEGIEVAFIPRHGKNHEFPPHEVPYRANIWALHELGVERVIGITAVGSLREEYKPGDIVITDQFIDFTKKREYTFYNGPRVAHVSMADPFCPEMRKIFYETAQELGFPVHEKGTYVCIEGPRFSTRAESAMFRQFAHIIGMTLVPEVVLARELGMCYVNIATITDYDVWADKPVDAQEVLKVMKENNYKVQEILKKGIPRIPEERKCGCADVLKTMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKX8</accession>
    <name>F0LKX8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467005.1">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="TM_pro_TauE-like"/>
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    </dbReference>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="251" mass="26832" checksum="A4040CCEDA62BA73" modified="2011-05-03" version="1">MLWHISIIFIGFFIGLFAGLFGIGGGFLIVPVLTLLGLPIHEAIGTSLACISMSALASAYGHLRRKNVLFRVVVIKEAFSIPSALLGAYITAFLNTRQLSAIFGFALIYVAYKLIKKPETPSVKRNVKVDYRKVPVIGVVSGFSSGLLGISGGILNVPLFYSLGLPIHYAIGTSSVALFFTALAGTVGHYILGQVHFDKAILLAPGLILGGFSGARLAHEIHPERLKMGFSLILLIIAIRMILKGLGFVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKY9</accession>
    <name>F0LKY9_THEBM</name>
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        <submittedName>
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        </submittedName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
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            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01921"/>
    <dbReference type="EnsemblBacteria" id="ADT84896">
        <property type="protein sequence ID" value="ADT84896"/>
        <property type="gene ID" value="TERMP_01921"/>
    </dbReference>
    <dbReference type="GeneID" id="10042237"/>
    <dbReference type="KEGG" id="tba:TERMP_01921"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1920"/>
    <dbReference type="eggNOG" id="arCOG05800">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1399806_0_0_2"/>
    <dbReference type="OMA" id="GKMYGAM"/>
    <dbReference type="OrthoDB" id="80280at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="200" mass="22574" checksum="339E024D198E7986" modified="2011-05-03" version="1">MKEIEELKNMLGKVEGKLIAAAKMYAAMNFSFWLFIMAGFYVLLELVNFKGIGLALYWMAAIVIGIPFTIKLWSRVERLQKIQQTGKKRKIVGAMIAIPWIVGSIIGWMIIPSMQIALNAEARLAVGFLSFIGISIGGMWLVVGREFEMVPAFLIPLCSIPVVWNMEEGAMIWAGFVVTASYSITVFWYLYSAFKAIERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
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    <organism evidence="6 7">
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        <lineage>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01939"/>
    <dbReference type="EnsemblBacteria" id="ADT84914">
        <property type="protein sequence ID" value="ADT84914"/>
        <property type="gene ID" value="TERMP_01939"/>
    </dbReference>
    <dbReference type="GeneID" id="26137478"/>
    <dbReference type="KEGG" id="tba:TERMP_01939"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1938"/>
    <dbReference type="eggNOG" id="arCOG01953">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_2"/>
    <dbReference type="OMA" id="MMMLYMG"/>
    <dbReference type="OrthoDB" id="79669at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="106"/>
        </location>
    </feature>
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        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="9"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="394" mass="43336" checksum="ED2F50EC971C271F" modified="2011-05-03" version="1">MQYILDLSILLVTAKTLEWLFEKREIHPIIAHILTGIILGPFVLNVISPSEPLKVLSEFGLLMMMLYMGLTSNFSAIATNKLKATVVAILGVAFSFVLGFMTVMAFGRGLAAAIFVGVTLGNTAIEVTSGVIVRERVKREISSILMGAAFADDIIAVYLIGIITALARGELSFVPLAVLTIKIALFIVAVLLISEFVFKRSKRFYGIVRNLNIFFTFTLVLTFLLALIAEEVGLHQIIGAYLAGLTISRLRERKDPLVISRIKLNELIEDLQVVLTEFFIPLFFIYVGLMFNPTMGKISLFMIVILYVAAVLGKLIGCSLGMKIFGFDWKKAFLVGIGMGGRGSLDIAILKFGLEKGLIDQSLFASIVIVSMLTAITTPQFFKLYLGKIREDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL10</accession>
    <name>F0LL10_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468213.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01942"/>
    <dbReference type="EnsemblBacteria" id="ADT84917">
        <property type="protein sequence ID" value="ADT84917"/>
        <property type="gene ID" value="TERMP_01942"/>
    </dbReference>
    <dbReference type="GeneID" id="26137481"/>
    <dbReference type="KEGG" id="tba:TERMP_01942"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1941"/>
    <dbReference type="eggNOG" id="arCOG01880">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031477_4_1_2"/>
    <dbReference type="OMA" id="IGAHIYF"/>
    <dbReference type="OrthoDB" id="96884at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="PTHR31303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="206" mass="22954" checksum="1D9245EEC91BE2CD" modified="2011-05-03" version="1">MSMKSEIKRKSLHLAGLTVPAVYLLFGKEAALFFVGLSFVMFIVLEPLRIVEHFRDRLKRKLGLYVDRQLIEIVEREIDIIAREHERRSIGAHIYFALAAFVIVYFFPRDIAIGSIAVATLGDAVAAIIGKPFGKHRFKNGKSLEGSLAYFVTALLILSSLIDLPHALIGALAGTLAEFYELPPDDNFSNQLAVAVTLYAFRNIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL18</accession>
    <name>F0LL18_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator Ptr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468221.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01950"/>
    <dbReference type="EnsemblBacteria" id="ADT84925">
        <property type="protein sequence ID" value="ADT84925"/>
        <property type="gene ID" value="TERMP_01950"/>
    </dbReference>
    <dbReference type="GeneID" id="26137495"/>
    <dbReference type="KEGG" id="tba:TERMP_01950"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1949"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OMA" id="EDCWFIA"/>
    <dbReference type="OrthoDB" id="97695at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="141" mass="15801" checksum="935F9771ECD0D55F" modified="2011-05-03" version="1">MIDERDRVIIDMLTKDARTPFTEIAKVLGISETAVRKRVRALEEAGIIKGYTVKVNPAKLGYNLVSITGVDTKPEKIFEVAHKLKEFEFVKELYLTSGDHMIMAEIWAKDGEDLADIISNKIGKIDGVTKVCPAIILERLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL39</accession>
    <name>F0LL39_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468242.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01972"/>
    <dbReference type="EnsemblBacteria" id="ADT84946">
        <property type="protein sequence ID" value="ADT84946"/>
        <property type="gene ID" value="TERMP_01972"/>
    </dbReference>
    <dbReference type="GeneID" id="26137516"/>
    <dbReference type="KEGG" id="tba:TERMP_01972"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1970"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062979_2_0_2"/>
    <dbReference type="OMA" id="VKREERC"/>
    <dbReference type="OrthoDB" id="27311at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="3">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="4">
        <location>
            <begin position="112"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="339" mass="39173" checksum="E00B781BE64D311A" modified="2011-05-03" version="1">MEISEKVLGMLTRLGFTKYEILTYWTLLVYGPSTAKEISERSGIPYNRVYDTIASLKTRRFVSEIDGSPRVYVAFSPSIAFLRFKKEVDEIKEQLEEELKRIKVKTEERPGVWRTKELDEAIEMVRESLERVEYEAILLSPGKFFIEIKDSLRNALKKGATLSIYTEGNIDLSELTNIGNLFVRKFHRLNHFIGMFDGREVINIQNIGFEPKNPPSFKATYPEIIFSQYSFLREAFGESELILEDINQKNELRFFADFHAVDVIRRYLGKCDIYAEVIAKSLSTNEIEELRGKVVGYTFALNEGIDNFELETDRGILKIGGMFAVLEDYETTKIKLILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL87</accession>
    <name>F0LL87_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467036.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00761"/>
    <dbReference type="EnsemblBacteria" id="ADT83738">
        <property type="protein sequence ID" value="ADT83738"/>
        <property type="gene ID" value="TERMP_00761"/>
    </dbReference>
    <dbReference type="GeneID" id="26136213"/>
    <dbReference type="KEGG" id="tba:TERMP_00761"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.763"/>
    <dbReference type="eggNOG" id="arCOG05828">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2748408_0_0_2"/>
    <dbReference type="OMA" id="PMEVRRY"/>
    <dbReference type="OrthoDB" id="127256at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="70" mass="8438" checksum="12D00E787A4BB974" modified="2011-05-03" version="1">MKHLKVLNILKGKELTAEEISREVRISHPEVRRILLRLAEQGKVESLQKEGKILWRLKQRTREEEEFKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL99</accession>
    <name>F0LL99_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00773"/>
    <dbReference type="EnsemblBacteria" id="ADT83750">
        <property type="protein sequence ID" value="ADT83750"/>
        <property type="gene ID" value="TERMP_00773"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00773"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.775"/>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1141286_0_0_2"/>
    <dbReference type="OMA" id="FHPWEFT"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="215" mass="25214" checksum="8981140221DF37A1" modified="2011-05-03" version="1">MEEGLPKILDLLNEKNVRATFFFTAEMARKYPNLAKRIIDEGHELACHGFNHERFDKLEKDRADFILEKALNILREFGDVVSFRAPNLQFPDYLFPALSKNGILLDSSKARYKGYKGGVKVVDGVLEVPVSITSSILRLPWSVQKAIHKKLREPRIYFAHPWEFVSMKKERIRLDCKFNTGDKALMFLERLIDYYKTQNAKFVMMQEYLNVYREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLC9</accession>
    <name>F0LLC9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467078.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00803"/>
    <dbReference type="EnsemblBacteria" id="ADT83780">
        <property type="protein sequence ID" value="ADT83780"/>
        <property type="gene ID" value="TERMP_00803"/>
    </dbReference>
    <dbReference type="GeneID" id="10041121"/>
    <dbReference type="KEGG" id="tba:TERMP_00803"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.805"/>
    <dbReference type="eggNOG" id="arCOG07104">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2230511_0_0_2"/>
    <dbReference type="OMA" id="QRENVFD"/>
    <dbReference type="OrthoDB" id="142699at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="105" mass="12283" checksum="2B4031E2C5D2303E" modified="2011-05-03" version="1">MSIITRLSRTGKYEKIEFVLKLVDRILAGDDIFDDRVLLMDTIEEMYRILRQLALNSKDENLLTAFEKMAILRHSLQRENVFDRKTLSDIKPVLLNTLKERSGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLF1</accession>
    <name>F0LLF1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468276.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84980">
        <property type="protein sequence ID" value="ADT84980"/>
        <property type="gene ID" value="TERMP_02006"/>
    </dbReference>
    <dbReference type="GeneID" id="26137610"/>
    <dbReference type="KEGG" id="tba:TERMP_02006"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2003"/>
    <dbReference type="eggNOG" id="arCOG05740">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1253649_0_0_2"/>
    <dbReference type="OMA" id="DQFYFIL"/>
    <dbReference type="OrthoDB" id="84255at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="220" mass="25556" checksum="C78D2B76DC39F1B3" modified="2011-05-03" version="1">MAEQQGQANQLVNKFVVSLVDGTILGYVTDINVEVEGDQFYFILRMKVLENLGKTGEFHSGMFSTEKKIRIRPSDIVNVGGDVIILGDGKVPPLREIERLHQIATEYNTLVRELEQKDMMIKELKEENKQLNKQIDELMKELRRLQVIKEDFEHLKEQLIKQEGQLEMAKEYIRLLEGLRHDIDQIKADVERLVKGYLEDAVRRIINEELNARGLKKTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLG1</accession>
    <name>F0LLG1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S27ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps27ae</name>
        <name evidence="8" type="ordered locus">TERMP_02016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02016"/>
    <dbReference type="EnsemblBacteria" id="ADT84990">
        <property type="protein sequence ID" value="ADT84990"/>
        <property type="gene ID" value="TERMP_02016"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02016"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2013"/>
    <dbReference type="eggNOG" id="arCOG04183">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179743_2_0_2"/>
    <dbReference type="OMA" id="GVFMAEH"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00777">
        <property type="entry name" value="Ribosomal_S27ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_S27a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022845">
        <property type="entry name" value="Ribosomal_S27ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ribosomal_S27" evidence="7">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="51" mass="6069" checksum="7166BDD9EB8B5114" modified="2011-05-03" version="1">MMGQKWKLYEVKDGKVVRKNKYCPRCGPGVFMANHKDRWACGRCGYTEWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLH2</accession>
    <name>F0LLH2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468297.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02027"/>
    <dbReference type="EnsemblBacteria" id="ADT85001">
        <property type="protein sequence ID" value="ADT85001"/>
        <property type="gene ID" value="TERMP_02027"/>
    </dbReference>
    <dbReference type="GeneID" id="10042342"/>
    <dbReference type="KEGG" id="tba:TERMP_02027"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2024"/>
    <dbReference type="eggNOG" id="arCOG05787">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_382952_0_0_2"/>
    <dbReference type="OMA" id="AYNQTPR"/>
    <dbReference type="OrthoDB" id="22470at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="698" mass="80067" checksum="CE5FAD774CED992C" modified="2011-05-03" version="1">MRRRGFVLTLDALLSLLLIMIFVSTIAVIENNVGTYTTYMREQEKYIAEDTLTLLRSTSLKELVPPQKIQEWLADGTLNTTLVSPDMSPLDIVSTYWATELIYPSANLRHKAEIILGYVLNRTLMGYNYELMINNYTSPYLRKTGSNSSRVPNISPATLILSGYAYNQTPRGYMARAYLTKATYRRQEIIGIQRVLAYCGVSNTFRVEAPIRLPDDASINSADIRLVARTSAQYSYFELNNVTLPLGTSDITNILHGGLNVLEATFTPASWYCYEMGFGSGSTLFADYTTNSLSVEDPATRYGELYQLESDRTGIYYLNALFVPGNITEINIHLETEGVRDIRIYYSYGSYHYELVHKTVPTTGRQIVDITNSEIVSALASYGFTYENLSRTYFKLIIALDSWWDESQRRFVYDTTPRRRILYGYGASRIEIKYIPRVLVTQYSIPLSIFIDYNDITYNGPCYGVRCAEMTFDYTLPENAKPWYVDIWTAIQFTTFTPDATMTLSENGYTFYDYYPDIYLIRVAYTRLTDTMMVPGRTNTFRAYSTDAYQFGFREGESRGVVNYFIEGYAGYGDVFPQLLQGYPRYKGYNLTYWYYDGSSTYQRQILIGDPPYKLITVDDLDPQRYAVDDAILRLFNNLNYINDVNPDDWKTSPYDGSQNNPIDVDLPEGVKIAFASMGEIPGLFKPITITLRVWREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLH7</accession>
    <name>F0LLH7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase</fullName>
            <ecNumber evidence="3">6.3.4.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purP</name>
        <name evidence="6" type="ordered locus">TERMP_02032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24836"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.23" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468302.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02032"/>
    <dbReference type="EnsemblBacteria" id="ADT85006">
        <property type="protein sequence ID" value="ADT85006"/>
        <property type="gene ID" value="TERMP_02032"/>
    </dbReference>
    <dbReference type="GeneID" id="10042347"/>
    <dbReference type="KEGG" id="tba:TERMP_02032"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2029"/>
    <dbReference type="eggNOG" id="arCOG04346">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065084_0_0_2"/>
    <dbReference type="OMA" id="CIHYFYS"/>
    <dbReference type="OrthoDB" id="21169at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01163">
        <property type="entry name" value="IMP_biosynth_PurP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023656">
        <property type="entry name" value="IMP_biosynth_PurP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009720">
        <property type="entry name" value="IMP_biosynth_PurP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010672">
        <property type="entry name" value="IMP_biosynth_PurP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38147">
        <property type="entry name" value="PTHR38147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06849">
        <property type="entry name" value="DUF1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06973">
        <property type="entry name" value="DUF1297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004602">
        <property type="entry name" value="ATPgrasp_PurP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="100"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</name>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</name>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</name>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT85006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="333" mass="38148" checksum="85F88E321A7EA88B" modified="2011-05-03" version="1">MEWKIATYASHSALQILKGAKDEGFKTVAFGREKVKPLYTKYFPVADEYLIGECPEEELLKRNAIVIPHGSFVAHLGIEKVESMKVLYYGNKAVLRWESDRKLERKWLEKAKLKIPRVYNDPDNIDKPVIVKFHGAKGGKGYFLAKNPEDFWTKAEKAGIKNKEQLKEVQIQEYIIGVPVYPHYFYSKLNDGLELMSIDRRYETNVDGIGRILARDQLELSLENSYVVVGNIPIVLRESLLMKVIEMGERVVKAAEKLMGGLWGPFCLETILTDELEFVVFEISARIVAGTNPFINGSPYTWLKYKKPMSTGRRIAIEIKQAIEENRLDEILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLJ6</accession>
    <name>F0LLJ6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_02051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPF0165 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468321.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02051"/>
    <dbReference type="EnsemblBacteria" id="ADT85025">
        <property type="protein sequence ID" value="ADT85025"/>
        <property type="gene ID" value="TERMP_02051"/>
    </dbReference>
    <dbReference type="GeneID" id="10042366"/>
    <dbReference type="KEGG" id="tba:TERMP_02051"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2048"/>
    <dbReference type="eggNOG" id="arCOG03880">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200885_2_0_2"/>
    <dbReference type="OrthoDB" id="130343at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008203">
        <property type="entry name" value="AF2212-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024069">
        <property type="entry name" value="AF2212-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01954">
        <property type="entry name" value="DUF104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT85025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="66" mass="7735" checksum="4CE905269D3ACC18" modified="2011-05-03" version="1">MEVIEAIYEDGILKPLKKLNLKEKEKVILVIREKVIDDDFITLIEELSKKVPKVENASKLLEEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLK8</accession>
    <name>F0LLK8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02063"/>
    <dbReference type="EnsemblBacteria" id="ADT85037">
        <property type="protein sequence ID" value="ADT85037"/>
        <property type="gene ID" value="TERMP_02063"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02063"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2060"/>
    <dbReference type="HOGENOM" id="CLU_3283049_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="40" mass="4978" checksum="8D46B840DC17FA40" modified="2011-05-03" version="1">MYRRFDLNELKEIIEEDLKAGEEEYHKERYNISSIAFLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLL2</accession>
    <name>F0LLL2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-glycerate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00812"/>
    <dbReference type="EnsemblBacteria" id="ADT83789">
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
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        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
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        <location>
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            <end position="138"/>
        </location>
    </feature>
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        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
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        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
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        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
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        <location>
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            <end position="297"/>
        </location>
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            <end position="336"/>
        </location>
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            <end position="365"/>
        </location>
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            <begin position="372"/>
            <end position="390"/>
        </location>
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            <end position="416"/>
        </location>
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            <end position="460"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="461" mass="47932" checksum="25CACC1CCBB5183C" modified="2011-05-03" version="1">MIDALYGQEGNSMVPGSILLLLLAIAVGLIILFTGKYRVHAFLVLLAAAYFVGIFSGLGLAKTVDAIAAGFGGTLKSIGIVIAAGTIIGYILEKSGGAISMAEAVLKIVGKHRVPHAMSIIGYIVSIPVFCDSGFVILSPLNKALSKRAGISLAVTAVALSTGLYATHTLVPPTPGPIAAAANLNADLGLVILLGLIASIPAALAGLYYGLKVGSKIYIEPDIEESYEDLIKKYGKLPPAKWAFAPLVVPIILIVLKSIADFPSHPFGTGMAKEFFDFIGHPITALLLGVLLSFKLVDKLDEHVYGPTGWVAEGLKNAAIIILITGAGGSFGYVLRQTGIGDYIGTTLSSYHLGLILPFIIAALLKTAQGSSTVAIITTSALLAPLLPSLGLSTPYGRALTVLAIGAGSMVVSHANDSYFWVVTQFSNMDVMQGYKLQTVATFVEGIVAAIVILIMGAVLL</sequence>
</entry>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="ADT83857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="51" mass="5764" checksum="4CC9957F4A57F0E0" modified="2011-05-03" version="1">MGVITVSVDDGVEERFRKLVAKKYGRIRGALGVAVTEAMKLWIEKVEQEEK</sequence>
</entry>
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    <accession>F0LLT7</accession>
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            <fullName evidence="2">Biofilm PGA synthesis PgaC-like N-glycosyltransferase</fullName>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="309" mass="35678" checksum="0FBBA05999A999AB" modified="2011-05-03" version="1">MYFPRISIGIPVYNEQENIQKLLLSILCQKGVNIREIIIINDGSTDNTLKKIMEISSIIERDIVLKVINLRHNIGKANALNIIFRIASSEYLVLLDSDVILMDEYTLKRLVYPLIKNEDIGLVSGWYEISSYSSINMSVFNKIITWAYKFSAKLLKEIGSNFGVYGATGAIMAVPRNIYKELQLPTNMLRDDLYVYLDVLSKNKKFVFQPNAKVIVHINPTLKNYLRYQVRVRSIPKDIIIGFGNIAQEELRKPPYSMLLLTLLRLSIKYPLEGISWVLLKVISLIYIKYLKNIKISVRWRARKEGINE</sequence>
</entry>
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    <accession>F0LLU7</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="10042387"/>
    <dbReference type="KEGG" id="tba:TERMP_02072"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2069"/>
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    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="76" mass="8857" checksum="04152BDB1BF11F3E" modified="2011-05-03" version="1">MPLAKEDLKVGRSILSRESYYEFTCPFCGAFQKAELKEPINLKIKFPMKRGMKRLLESDTVQLIFYREGGKELEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLV7</accession>
    <name>F0LLV7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
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            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="26137698"/>
    <dbReference type="KEGG" id="tba:TERMP_02082"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2079"/>
    <dbReference type="HOGENOM" id="CLU_2821103_0_0_2"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="66" mass="7844" checksum="C1331CE60325C78C" modified="2011-05-03" version="1">MKNLKVEIIVPDNVKKRKVGKKIKEYIEAVKAAERLNKLLDEVDLDEIEKEVEDFRKKFKFRSSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLW3</accession>
    <name>F0LLW3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
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            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
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            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468358.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02088"/>
    <dbReference type="EnsemblBacteria" id="ADT85062">
        <property type="protein sequence ID" value="ADT85062"/>
        <property type="gene ID" value="TERMP_02088"/>
    </dbReference>
    <dbReference type="GeneID" id="10042403"/>
    <dbReference type="KEGG" id="tba:TERMP_02088"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2085"/>
    <dbReference type="eggNOG" id="arCOG00710">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134210_2_0_2"/>
    <dbReference type="OMA" id="KFRFFID"/>
    <dbReference type="OrthoDB" id="88061at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="162" mass="18295" checksum="E3B1726E82C62C7E" modified="2011-05-03" version="1">MTSGKFRFFIDSNVILNYFYGDENAREIIEIAESIGEIFINGIVLTEVSIRYVKDKTGEKSYTLKHKPELVKNVDKSPLYAVLGKFLYLPDNVLIGEDAVTLMDIYGILPNDAIILATCKFYGIKYLISFDSDFREACEKEGITLIESKEKLNEIIKSGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLX0</accession>
    <name>F0LLX0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468365.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02095"/>
    <dbReference type="EnsemblBacteria" id="ADT85069">
        <property type="protein sequence ID" value="ADT85069"/>
        <property type="gene ID" value="TERMP_02095"/>
    </dbReference>
    <dbReference type="GeneID" id="10042410"/>
    <dbReference type="KEGG" id="tba:TERMP_02095"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2092"/>
    <dbReference type="eggNOG" id="arCOG06566">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_520356_0_0_2"/>
    <dbReference type="OrthoDB" id="143554at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="523" mass="60559" checksum="86657A367747A50F" modified="2011-05-03" version="1">MRQLLKTLITILVFVLTLALPIFYYTLGITGAFNFRVTSAIYQFLNSSYVNIRDPSVGDGYPFYVPAVIFSNIILSKITTISPKDFQFLPILSLPYLFSLGVLYNKMSKSNDYMYLSFAVYITIWGSLGLAGKAAYSPMFPHSWGSTLYPLIVVLIANISEMGSIRRTLILLILVSANHLYSYTSEGWSLFFIYSVMVSSVLIYRSSKPKSEEKGKIHRLWYTLLFISILFSFNRMLFHHFLKDYQIDISYLYSNSLGFFRRFFIKSPTSPHTYVSDPTSTIIHLMYFLAVVFILVYGITSRVVCLLKNNNINNDMEHNIIVLSFWGVFIGEFLTYGIAGIILYRYIALWGAIFVVIFLKELKDSTSALFIKRVVNMLLIFLLIISTLGVVTTYEYKTINISPSRYEYITRSFMWLYHSTDNTITILGDLITVDKYYLEARARQLPLKIQRRYVDEKTYSALSGLSEYCKESHSNYILLNLRLNVVETPGWKFFKPYTYYLDPIYTNRCFDIIYTDNAVIIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMD5</accession>
    <name>F0LMD5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468454.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02184"/>
    <dbReference type="EnsemblBacteria" id="ADT85158">
        <property type="protein sequence ID" value="ADT85158"/>
        <property type="gene ID" value="TERMP_02184"/>
    </dbReference>
    <dbReference type="GeneID" id="10042499"/>
    <dbReference type="KEGG" id="tba:TERMP_02184"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2179"/>
    <dbReference type="eggNOG" id="arCOG04329">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075234_0_0_2"/>
    <dbReference type="OMA" id="KKWHLFW"/>
    <dbReference type="OrthoDB" id="76280at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009927">
        <property type="entry name" value="DUF1464"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07318">
        <property type="entry name" value="DUF1464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009433">
        <property type="entry name" value="DUF1464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="355" mass="39320" checksum="61B691A205957A73" modified="2011-05-03" version="1">MRVIGVDPGTRSFDVIGLKDGKIKLDLSFPSEVVAEEPSKIVKAIEEFNADIIIGPSGYGVPLKHISELTERDRFEMTLVREEEMKQIPVLIGLQKMVNEMKEKDMNVWFIPGIIHLPTVPEFRKYNKIDMGTADKMAITVLAIYDQAKRLGISYEEVSFALLEVGFGYNFAGAVDRGRIVDGIGGTIFPGPAFVNSGALDGEVAYLVGEIKKWHLFYGGASIIAAGEILSPEEFAKRLDEESFAKAWEAMKDGFVKAIASELTVIEKPKEIILSGRLMRIRELREDVKDLFEEKFGLPVVKQRGLEGKAKEAAQGSAIIGDGLLGGQFKDLIEHVEIRKARGSVLDYVKFPLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LME3</accession>
    <name>F0LME3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RCK C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02192"/>
    <dbReference type="EnsemblBacteria" id="ADT85166">
        <property type="protein sequence ID" value="ADT85166"/>
        <property type="gene ID" value="TERMP_02192"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02192"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2187"/>
    <dbReference type="eggNOG" id="arCOG05758">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088248_0_0_2"/>
    <dbReference type="OMA" id="IMNHPVR"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="116"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="232" mass="26085" checksum="69F73D628BD9D7A3" modified="2011-05-03" version="1">MTGLSRDVAAFQAQSAFSGTGFTTSESEYVVSHPIRRKIIRILIFLGSAGITSAIATLVLTFIGKSAEEVKQNFVILLSGLLILYFFVRSKWIDKMMRKVIRRLLNRFFPSLKIYDYNQLLGISRGYSIGQIKVRKSSWLANKTLRELQLDKEGVLVLGIYRKVGEKEVYLGAPSGDTKILPGDLVVLYGPEEVILNLSKRVKGIKGKIEHEEAVEKAKIRAMQEEMELKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMF8</accession>
    <name>F0LMF8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468477.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02207"/>
    <dbReference type="EnsemblBacteria" id="ADT85181">
        <property type="protein sequence ID" value="ADT85181"/>
        <property type="gene ID" value="TERMP_02207"/>
    </dbReference>
    <dbReference type="GeneID" id="10042522"/>
    <dbReference type="KEGG" id="tba:TERMP_02207"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2202"/>
    <dbReference type="eggNOG" id="arCOG13128">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_835819_0_0_2"/>
    <dbReference type="OMA" id="PTFAWAD"/>
    <dbReference type="OrthoDB" id="133736at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="330" mass="37224" checksum="EE34915A11177C90" modified="2011-05-03" version="1">MRKLPLILVVLNLFSLVMVSAYSFNFSVDNYEIIEKPTFAWADFGSTTFEWHGYELNTTDYLYWAGILVSVSDNCTLKDEVKIVDKNGKRLHVGYGTSPAGGTLYIPIFEADLYSSPGLNGGPYTFNITLRVENCEVVVKDFIFVTSKTHPKEFPLKLIPPNRCPWSKPALRSFEFGNKTYWKEFELNFTYIYDGGFSDLVVGWKSEPCPILSLYNGSVCLSDDYCHCHEAKASLQPGIYRIALGLKDGNLSVKIFDDKVVFEKSVHIRHPLYLESIGEPCSGKIVGNVSFYGIEGSPSETFYTPEDDYGGFVFAVAVVIALIIAFRWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMK0</accession>
    <name>F0LMK0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01003</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467277.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01003"/>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Methyltr_RsmF_N"/>
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        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NusB-like_sf"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RCMTFAMILY"/>
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    </dbReference>
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        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="191"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="281"/>
            <end position="287"/>
        </location>
    </feature>
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        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="305"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
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        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="465" mass="53503" checksum="9E2401DD78C7851F" modified="2011-05-03" version="1">MEEISNAIIQLIEREKEGEKKLSIPPKGVRALIEAVRLAEIIKPSQYAKREAFKKHQIDEYYLNRMLTMLFYDIMKKQGLIDRVINDIVGVNPLILDPWLRAALRVVVDVSLFHHSKPGTLKALKWKGSDFISSKTHPYVGMYYWDIFDKVIRYKPRPKSRDEFLEWKYIAPIWLIRRIKKLLGEETEQFFQAVNSKHSWTSIRVNTLKTTVDEVVEALRSEGKEVKVSERVPTIVKIKGPYDFDRSKLFREGKILVQEEASAVASLILDPKPGMTVVDLAAAPGGKTSHIAELMRNKGKIYAFDIDEFRIKRMKEILKRMGVNIVKIIRKDGRKAPKILGRGIADRVLLDAPCTSSGTIGKNPELRWRLRENKILEIAELQKDLLKVAAQLLKPGGRLLYATCSLFPEENEENIEWFLGTYDNFRLIPLNGPYDESPLLKGTMRAYPHRHGTIGFFYALLEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMK2</accession>
    <name>F0LMK2_THEBM</name>
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        <submittedName>
            <fullName evidence="2">MinD-like P-loop ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="protein sequence ID" value="ADT83981"/>
        <property type="gene ID" value="TERMP_01005"/>
    </dbReference>
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    <dbReference type="KEGG" id="tba:TERMP_01005"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1008"/>
    <dbReference type="eggNOG" id="arCOG04073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="50469at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="4FE4S_FER_1"/>
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    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="286" mass="31411" checksum="512EDF45364DD9A8" modified="2011-05-03" version="1">MQIAVSGGKGGTGKSTIAINLAIALRNYFDLTLADLDVEAPNDHILLGIELQNEEPVELFMPRFDYSKCIKCRRCAEVCEEHAIITMRDGTPFLMPTLCSGCGACRIVCPVEGAILEGKKLMGHTYLTETPYGFQLVTGKLLEGEERAMPIVVAAKERAKALNKELLIVDTAAGTSNTVSKALEDSQLIIAVTEPTPLGLHDLELILKLADIMGIEAWVVINRSDLGKKEDVKELARRYNARITAEIPYSENIIKSYVEGRPIVLSDCGEAEIFRKLAEEVVSYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMK7</accession>
    <name>F0LMK7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01010"/>
    <dbReference type="EnsemblBacteria" id="ADT83986">
        <property type="protein sequence ID" value="ADT83986"/>
        <property type="gene ID" value="TERMP_01010"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01010"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1013"/>
    <dbReference type="eggNOG" id="arCOG13126">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3130990_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="50" mass="6210" checksum="E3D1162C60944E9E" modified="2011-05-03" version="1">MREYIKPQSFEFVCPFCGYRARSLEELKQHIFEKHTFNREDIRGSRFIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMM3</accession>
    <name>F0LMM3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Septum site-determining protein MinD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParA family. MinD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467300.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01026"/>
    <dbReference type="EnsemblBacteria" id="ADT84002">
        <property type="protein sequence ID" value="ADT84002"/>
        <property type="gene ID" value="TERMP_01026"/>
    </dbReference>
    <dbReference type="GeneID" id="26136476"/>
    <dbReference type="KEGG" id="tba:TERMP_01026"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1029"/>
    <dbReference type="eggNOG" id="arCOG00589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_3_2"/>
    <dbReference type="OMA" id="CESAKAY"/>
    <dbReference type="OrthoDB" id="105856at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010224">
        <property type="entry name" value="MinD_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01969">
        <property type="entry name" value="minD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="260" mass="27771" checksum="9F079074CC62AB54" modified="2011-05-03" version="1">MEGRSIVFASGKGGTGKTTVVANLGVALAQFGKEVIVIDADITMANLSLILGMEDIPVTLHDVLAREADLRDAIYEGPAGVKVIPGGLSLEKIKKAKPERLRELIREISQMGDFILIDAPAGLEITSVTALLIGKELIVVTNPEISAITDSLKTKLVAEKLGTLPLGAVLNRVTNEKTELTKEEIEAILEVPVLAIIPEDPEVKRASAYGVPLVVKNPTSPAAIAIKQLAAKLAGIRWQPPEPESPIKRVFRALFGGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMN4</accession>
    <name>F0LMN4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01037"/>
    <dbReference type="EnsemblBacteria" id="ADT84013">
        <property type="protein sequence ID" value="ADT84013"/>
        <property type="gene ID" value="TERMP_01037"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01037"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1040"/>
    <dbReference type="HOGENOM" id="CLU_3264014_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="41" mass="4592" checksum="9C3BDB0167AB7675" modified="2011-05-03" version="1">MKRYGGAFMPASIVFLWFGIPAVYVALALVYFLFSKDEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMR4</accession>
    <name>F0LMR4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467341.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01067"/>
    <dbReference type="EnsemblBacteria" id="ADT84043">
        <property type="protein sequence ID" value="ADT84043"/>
        <property type="gene ID" value="TERMP_01067"/>
    </dbReference>
    <dbReference type="GeneID" id="25394633"/>
    <dbReference type="KEGG" id="tba:TERMP_01067"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1070"/>
    <dbReference type="eggNOG" id="arCOG00388">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054697_2_0_2"/>
    <dbReference type="OMA" id="IPYERWY"/>
    <dbReference type="OrthoDB" id="48337at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="428" mass="48875" checksum="2EE4C60DEAC2D768" modified="2011-05-03" version="1">MMRKKVLTTSLVMIFMLSLIPISHAADVNIVILVSDNEADSTLADSVANIINAYAVIKVPWGIYNPNYSAEVLKYAPDKVIIIGGPTAVPIDYEKDLEEMDIPFERWYGKNRYETNLVVVQKLKEEFPEEFSQIETVYIVHGRDVLSMLMQRWLDALPNVAKYKSIWVFTGDGYENLSLQVLDDILEASQGRPWVEVIVTSRWIQLEHKKVPKPLFNINTDEIANFLRKKGYEVTVGNYTRGTYFTIKYAGTIGQVVLETLKLVDNKTQVAENFLDGLDIPEAKKRLNMAKEQITKAWKLYSLGNYQEAYLLAVAANRNADFVISMSAKEWNKIAQMSLNYALNREVLRLEARINALKVLGINTESVEEVLAEIKLAIKSKNYSKALKLIKEAKEELREMFINEKRHPLPVPPDHREERGGHAKNPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMS3</accession>
    <name>F0LMS3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84052">
        <property type="protein sequence ID" value="ADT84052"/>
        <property type="gene ID" value="TERMP_01076"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01076"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1079"/>
    <dbReference type="eggNOG" id="arCOG13123">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2490614_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="86" mass="9772" checksum="24F92DE46B74B06E" modified="2011-05-03" version="1">MEYLKRIGSYLLAAGTLTLLFKNILSLSLPHLFLWWFFVFLLFDLSISGFQRLFELKYPKLRTVGIAVGMVFSAVVICIIGNILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMV1</accession>
    <name>F0LMV1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467378.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01104"/>
    <dbReference type="EnsemblBacteria" id="ADT84080">
        <property type="protein sequence ID" value="ADT84080"/>
        <property type="gene ID" value="TERMP_01104"/>
    </dbReference>
    <dbReference type="GeneID" id="10041421"/>
    <dbReference type="KEGG" id="tba:TERMP_01104"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1107"/>
    <dbReference type="HOGENOM" id="CLU_1782578_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="145" mass="16468" checksum="2BEE21BF8D761711" modified="2011-05-03" version="1">MNWEKTLRDYERTNRRIGRIFILLGIVIAVFGIINVYLNFEYLCIQAFGTVYPNTSSALAFTAFLLPYLFTGTGLGLLGITIERKLNLKNAEVPLVVLILLPIMYSTTKFLLSSLMETYYSPISMIESVLISVFLIAGYLFTKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMZ3</accession>
    <name>F0LMZ3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase chain B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467420.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01146"/>
    <dbReference type="EnsemblBacteria" id="ADT84122">
        <property type="protein sequence ID" value="ADT84122"/>
        <property type="gene ID" value="TERMP_01146"/>
    </dbReference>
    <dbReference type="GeneID" id="10041463"/>
    <dbReference type="GeneID" id="26136609"/>
    <dbReference type="KEGG" id="tba:TERMP_01146"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1149"/>
    <dbReference type="eggNOG" id="arCOG01553">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="1">
        <location>
            <begin position="16"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="192" mass="21239" checksum="50E5CE0646E8C2B3" modified="2011-05-03" version="1">MFEKSLWVFHLNSGSCNGCDIEILNIFAPKQDVERFGIKLVGSPRHADAIAFTGPVTRECLPKVIEAFKAVPEPKIVLAIGSCACGGGIWYDTYAVIGGVKELYKILKEEYGIEPPTTIYIPGCPPKPEAIIYAVAMARGLVKQKQKREIYIEELDEKTERDIVEILFGEAKETRHFVPNIVVKTDGGADEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMZ7</accession>
    <name>F0LMZ7_THEBM</name>
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            <fullName evidence="3">Hydrogenase-4 component B</fullName>
        </submittedName>
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        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="ADT84126">
        <property type="protein sequence ID" value="ADT84126"/>
        <property type="gene ID" value="TERMP_01150"/>
    </dbReference>
    <dbReference type="GeneID" id="10041467"/>
    <dbReference type="KEGG" id="tba:TERMP_01150"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1153"/>
    <dbReference type="eggNOG" id="arCOG01537">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_8_1_2"/>
    <dbReference type="OMA" id="YFCMTKA"/>
    <dbReference type="OrthoDB" id="28394at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="2">
        <location>
            <begin position="134"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="635" mass="69471" checksum="F2C9C2383809D14E" modified="2011-05-03" version="1">METQMLLIPVGILIVAAVVGLSKAKISLKMVSTLSAIASVVMIYIGILGFEATLELKYNLFNSSSLFATLNWLVFRVDSLSAFFLLLLGILSLCASVYGIKYMEKYLGKEDMRVYTFNYPIFLLTMYFVLICWNLLWFIIFWELMSLFSQFLVAFEQSEEKAVKAAFKYFCMTKAGAEFLVLAVVLIILKVTSFNADYSEIASILPAYLSAHLGVLYALTFALLIGFGVKAAMIPFHSWLPDAHPEAPSNVSALLSGIMIKLPIYMMLRFFITFFPLEPEIGLIIAVFGVLTLFFSMMYALLQEDSKRLLAFSSIDNIGYILLPMGAGIYFLANGNQLLGSVALAAALFHTMNHAFFKGLLFLTAGSVMYETGTRDLNYLGSLAKKMPLTAFAALIGSLAIAGMPPLNGFVSKWMIYISTLSSPATSLFGIIAIFISAVTLGAFVKYFTAIFTKPAVKEINAKEVPLLMSAPQILLALLCIAFGIYPFVPLKMISQALGAIGVPLASLVVYPSLVVPKTGSYSPVIVFAFLLVSTLIALLILPSKGSVMSTWKTGRSEDLNVGMPADAYYRDFREAFNEVYLLGDASKDIVQKVARIGKAFGTKFEVLSYDLDSMLSLAMILIVILVAVLGGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN01</accession>
    <name>F0LN01_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S cluster-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467428.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01154"/>
    <dbReference type="EnsemblBacteria" id="ADT84130">
        <property type="protein sequence ID" value="ADT84130"/>
        <property type="gene ID" value="TERMP_01154"/>
    </dbReference>
    <dbReference type="GeneID" id="10041471"/>
    <dbReference type="KEGG" id="tba:TERMP_01154"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1157"/>
    <dbReference type="eggNOG" id="arCOG01500">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_3_1_2"/>
    <dbReference type="OMA" id="DMQRCIG"/>
    <dbReference type="OrthoDB" id="105930at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12800">
        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="211" mass="23851" checksum="861E161DE46A6264" modified="2011-05-03" version="1">MSLLKTSLERPTIYIDPKKCMGCRSCEIACAVEHSMSKTLFGAIFEKPTPKPRLKVVVADFFNVPLRCQHCEDAPCMKVCPTGAIKKSEEGFVILNTNKCIGCLMCVMACPFGHPKYEPEYKVVLKCDSCIERVREGREPACVEACPTKALKFGTLEEILDEIRKERAEELISGLKVPGIVYMKPVVEEKKKEERISPMDVYAAYLEVKWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN02</accession>
    <name>F0LN02_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic molybdate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT84131">
        <property type="protein sequence ID" value="ADT84131"/>
        <property type="gene ID" value="TERMP_01155"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01155"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1158"/>
    <dbReference type="eggNOG" id="arCOG00223">
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    <dbReference type="OMA" id="SPSTYWE"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="259"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="340" mass="38671" checksum="1EDF5E80A5E509B3" modified="2011-05-03" version="1">MLPLEALEILSSHLEDFRFDEGLLTCPNPLLHPKIDIILRQTMELCKKLTLFIPVSVSRNFLNKTSLENVDFISLIIPSYKDIKSNLQTVKMLLSQGIDNLEAYILLDSNSDFAEILSTIELCKSYGLKITLGPKLYASPYADKFLEKIAKKENVEIGLHYGRKYFYNAIKVFIDNYPVTLLTSPGAENCKTLYLNPYGNFSKCPLSRFEVNYKKITKDDLRKMLFSPCAINRNVVGLSPKIRVSFVTKEGVEIPGEILELLELISQVNSFRAACKALGVSPSTYWEKIRSLEEKLGISLIISVRGGRKKGITILTEFAKDLLKEYREIREKAIVSLYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN22</accession>
    <name>F0LN22_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01175"/>
    <dbReference type="EnsemblBacteria" id="ADT84151">
        <property type="protein sequence ID" value="ADT84151"/>
        <property type="gene ID" value="TERMP_01175"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01175"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1178"/>
    <dbReference type="eggNOG" id="arCOG01895">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1648382_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="160" mass="18619" checksum="B3C39EBF301B448F" modified="2011-05-03" version="1">MGSLWLFFIRDIIHLELKFSNAYEKVHKRSLEEIDKVSERIGIKVALENMPKFPILDGQTAGRIYELIDGTNLYVTFDVGHLYTVSDDFAEFIEVLKDKIIHVHLHDNEGENDSHLALGEGIIPWDKVLRILPKNVTWSLEVRSLDDFKKSFEFLKSYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN23</accession>
    <name>F0LN23_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01176"/>
    <dbReference type="EnsemblBacteria" id="ADT84152">
        <property type="protein sequence ID" value="ADT84152"/>
        <property type="gene ID" value="TERMP_01176"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01176"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1179"/>
    <dbReference type="eggNOG" id="arCOG01895">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2420196_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="91" mass="10671" checksum="FC9F0519F8DAF20F" modified="2011-05-03" version="1">MIGASTYALFDRSLGVAIYKLREFPLDFVEIMSEGYHVLDKYNYRFHLEYLESYGMKNIIHAPFSDLNLAALNEKLRRVTLEIIFETLKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN87</accession>
    <name>F0LN87_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
            <plasmid evidence="2 3">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747448.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02253"/>
    <dbReference type="EnsemblBacteria" id="ADT85226">
        <property type="protein sequence ID" value="ADT85226"/>
        <property type="gene ID" value="TERMP_02253"/>
    </dbReference>
    <dbReference type="GeneID" id="10549077"/>
    <dbReference type="KEGG" id="tba:TERMP_02253"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2247"/>
    <dbReference type="HOGENOM" id="CLU_835814_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="332" mass="37834" checksum="9519A1FDE23A6519" modified="2011-05-03" version="1">MKRNVLISLFLLFLILPLNSSGAYYQYGWRYKAIIRPQNFIDVYTIPINETISGDNNIVSIRRNFTLSEEAQIIGITLRFSNLGENLAQDFNLFLIKKQGSSDKFGVGMSFDIYPLGNGEYIASTYLMNSSLYHTALYVENWRKEKFLEGNIVISAFLPEGSKTKIEDIKFYIYTQSRETDFVIKEIPNGYLLLPEPVTFKQLLLRIDASTPVTVYLKGEGGREHRVTLNPNLSSTQTFYIGFDSSSKKITVSKIQNENRITLKEIKSDSSWLQVARIFVPSLIRTKTVAISGEIYISENTEKGVSRDINLIGIILVGSFLLVIWLKRITKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGY4</accession>
    <name>F0LGY4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
            <shortName evidence="4">PIMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pcm</name>
        <name evidence="5" type="ordered locus">TERMP_01216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01216"/>
    <dbReference type="EnsemblBacteria" id="ADT84192">
        <property type="protein sequence ID" value="ADT84192"/>
        <property type="gene ID" value="TERMP_01216"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01216"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1218"/>
    <dbReference type="eggNOG" id="arCOG00976">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055432_2_0_2"/>
    <dbReference type="OMA" id="TISAIHM"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00090">
        <property type="entry name" value="PIMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="241" mass="27682" checksum="37FECBC403DAB6A6" modified="2011-05-03" version="1">MKALRDKLKYFFSKFFFVRAMSEEELYERWVRLVRQLEREGIIKSKRIKTAFLKVPRYKFVLDRYKHYAHVDEPLPIPAGQTISAPHMVAIMLEVADLKEGMNVLEIGTGSGWNAALIYELVKRDVYTIERIPELVEFAKRNLEEAGYKDKVHVILGDGTKGFPPKAPYDRIIVTAGAPKIPEPLIEQLKVGGKLIIPVGSYHLWQELYEVIKLDEKGRIKVINHGGVAFVPLIGEHGWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGZ6</accession>
    <name>F0LGZ6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467502.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01228"/>
    <dbReference type="EnsemblBacteria" id="ADT84204">
        <property type="protein sequence ID" value="ADT84204"/>
        <property type="gene ID" value="TERMP_01228"/>
    </dbReference>
    <dbReference type="GeneID" id="10041545"/>
    <dbReference type="KEGG" id="tba:TERMP_01228"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1229"/>
    <dbReference type="eggNOG" id="arCOG02168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513539_0_0_2"/>
    <dbReference type="OMA" id="VDGYWEW"/>
    <dbReference type="OrthoDB" id="23455at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="289"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="532" mass="61161" checksum="C7FF66640F0F43DD" modified="2011-05-03" version="1">MKKSAFLLLLIIFASGCLIKQPAVVTFEIDRTVVKAGGTFHIIVTINNTGKVAFIGADLAINNPDFKILQNPKFPSPLKVGEKVELVWIVKAPDKPGVYTIGVPLELIDELHRTWKGFYHEFTITVVKEETKMPPGELSMEVNVPSSVSGGKIFNITVELKNSGMTPIEIGEVSVNLLDGLKIINRSKIPEKIYGGQSYKIVYQIDAPYRHVSGYVTVIVNYFENGNEKKEIVSRYIEITWAPWFANNETLRKAYGDKYYWIENKYLVDGYWIERFNSTPYANVSILRNYALPLVLKSKSEVEAAKKIYSWILEHYKFGDTTASVDPQKILQQNKISYAEGQLLFTAMMKSINVPSRIVSLYNGTDCIINPLSEFYSGGRWYVVDFKHGFIGTRNEYIATPYFPRVYQLLTQGNFKLVAQAPEELKGHEHVDVGPDYLANLKDKLMTQVEKKLNPMLKTKLTLMLNRMNENEQIFALFIFASAPEKELNEMLLKYDYKDIERSMTALYEFYKDKPWPENFRKYWYILRGVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH10</accession>
    <name>F0LH10_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01242"/>
    <dbReference type="EnsemblBacteria" id="ADT84218">
        <property type="protein sequence ID" value="ADT84218"/>
        <property type="gene ID" value="TERMP_01242"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01242"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1244"/>
    <dbReference type="eggNOG" id="arCOG00135">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2313928_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="99" mass="11194" checksum="C531178B30612307" modified="2011-05-03" version="1">MKSKLYPLLLLTTVLRVTGDAIESIALPWHLLNQTSSLLSVAGYSLASMLPWVIFPPLMGRFLDKTEKKVRLAFLALFIQSFFALTIIKFASNIWAFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH52</accession>
    <name>F0LH52_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_00036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00036"/>
    <dbReference type="EnsemblBacteria" id="ADT83014">
        <property type="protein sequence ID" value="ADT83014"/>
        <property type="gene ID" value="TERMP_00036"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00036"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.35"/>
    <dbReference type="eggNOG" id="arCOG02569">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015263_5_1_2"/>
    <dbReference type="OMA" id="PMISGSG"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="454"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="514"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="576" mass="62536" checksum="A0B04FEE813A1876" modified="2011-05-03" version="1">MDAIISLMEWRTRRYAKRWAVILIFSFVAGLVGGFGAVVFRILIKVFHWIFFSFLLPYFSIYIGRFNLGYILLPVLGGILIAPLISRAPNIRGNGVPEVIEAFIFKEGTIAWKFAVMKTLATSVAIGSGASLGREGPIGFIGASLSSIISQIFGLHRDMKRLLTACGLAAGIAGTFNAPFAGALFALEVLYMGAFSINLVPIFIASITGNAVTLAVLGSASGIKIPSPLSYTVTELPFFFLMGVFSGVLAAFFVKLLYFVGDRFESSGFSPKLRLLIGGAAVGILGMLFPEYGVLGIGYEGMRLAMFGILPIYLLVLLIFLKATATIFSIASGYSGGIFAPSLYIGTAFGAVFGMVLRFFLPWVNPSSYALAGMAAFFSGVAQAPINQILMVAELTKDYTMLPPAMLSSVAGFLSARVLLKGSSVYTLKLERRGIKIKTGKPLILETISVGDIMTREPVFVYSSDPLFRVEKLISETGHDCFPVVDEKMGVVGIVGVRDLISCPDKSMSVEKLLQRPYAVAYPTETAQQALEKLITFNQNLLPVVESPKRNKLIGVVTKRDIYRAYYKGLEKMYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH59</accession>
    <name>F0LH59_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00043"/>
    <dbReference type="EnsemblBacteria" id="ADT83021">
        <property type="protein sequence ID" value="ADT83021"/>
        <property type="gene ID" value="TERMP_00043"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00043"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.44"/>
    <dbReference type="eggNOG" id="arCOG01142">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1387638_0_0_2"/>
    <dbReference type="OMA" id="MHISDTP"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="30"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="201" mass="23483" checksum="D7C28C7EA991BE4D" modified="2011-05-03" version="1">MKFEEMRLNLPNFLRRQKIPDILLRRDEKKIMHISDTPDNIYVFLLNLIEKTKPDYIIHTGDLVDNIKLERRPELRERYEKSLIELLHILENSKAEVYIVPGNEDDVSILRRHITLSKIVPPGTIIEIEGVKLAVGHRYGDVAEINNVDFKLYGHNFRLIPKGINGVLRINFILLPSKRVVGVKYPDGTNFERGYRLMRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH80</accession>
    <name>F0LH80_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466340.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00064"/>
    <dbReference type="EnsemblBacteria" id="ADT83042">
        <property type="protein sequence ID" value="ADT83042"/>
        <property type="gene ID" value="TERMP_00064"/>
    </dbReference>
    <dbReference type="GeneID" id="10040383"/>
    <dbReference type="KEGG" id="tba:TERMP_00064"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.64"/>
    <dbReference type="eggNOG" id="arCOG00288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_3_2"/>
    <dbReference type="OMA" id="GMERKPF"/>
    <dbReference type="OrthoDB" id="121018at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="186" mass="21552" checksum="646BADD01CE87FD6" modified="2011-05-03" version="1">MEFFEVIRRRSIRRFQNKEVPEELIEKILEAAFYSPSSKNRRPWHFVVVKDRGLIKKLAETRPAVRFLETAPLAIVVCGDERISNAWVYDCSIAAEHIQLAATALGLGACWGHIHERMHDDEKTAEDYVRELLGIPKHIRILCIIGIGYPAEEKPEHRKDEIMWERVHLNKFGNRVEQEGRDLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH84</accession>
    <name>F0LH84_THEBM</name>
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        <submittedName>
            <fullName evidence="6">Sulfhydrogenase II subunit g</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="4">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00068"/>
    <dbReference type="EnsemblBacteria" id="ADT83046">
        <property type="protein sequence ID" value="ADT83046"/>
        <property type="gene ID" value="TERMP_00068"/>
    </dbReference>
    <dbReference type="GeneID" id="10040387"/>
    <dbReference type="KEGG" id="tba:TERMP_00068"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.68"/>
    <dbReference type="eggNOG" id="arCOG02199">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_1_1_2"/>
    <dbReference type="OMA" id="YMTLERR"/>
    <dbReference type="OrthoDB" id="67226at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
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        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="289" mass="33053" checksum="DB7B5939C5C5A501" modified="2011-05-03" version="1">MNPFQTYDARILEVKELTPREKLFTLRFVDPEINREFTYRPGQFVIVDIRGFGEFPISLCSSPTRTGYFQLCIRRVGRMTKYIHKLKEGDIVGIRGPYGNGFPMEAMEGSNLLLVAGGLGMAPLRSVLWYAIDSGKYEQIYLFYGTKSYEDILFRDEIIHLLKHGEAMNCRVKLAYEVESPSCIYLEKGFAPKVCKGVVTDLFRGEEFDVDNTYALICGPPVMYRFVIRELLDRKLAPGRIYMTLERRMRCGIGKCGHCIVGTSTSIKYICKDGPVFTYWEALSTRGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH89</accession>
    <name>F0LH89_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466349.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00073"/>
    <dbReference type="EnsemblBacteria" id="ADT83051">
        <property type="protein sequence ID" value="ADT83051"/>
        <property type="gene ID" value="TERMP_00073"/>
    </dbReference>
    <dbReference type="GeneID" id="10040392"/>
    <dbReference type="KEGG" id="tba:TERMP_00073"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.73"/>
    <dbReference type="eggNOG" id="arCOG00893">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_985571_0_0_2"/>
    <dbReference type="OMA" id="CAVQLHT"/>
    <dbReference type="OrthoDB" id="47746at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011589">
        <property type="entry name" value="UCP004961"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42206">
        <property type="entry name" value="PTHR42206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004961">
        <property type="entry name" value="UCP004961_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="281" mass="32005" checksum="74B7CA396D949558" modified="2011-05-03" version="1">MIIFDNHFHVDPFKGLFLEAVKQFHRAGGTHLAVVYKTAHDYGFAGMKAEDFIEAMDFHIKLVEKINKETPVKAFAVVGVHPAEFVYLAEKKSLEYAKDEVMKALEYAQKLCLEGKAIAIGEIGRPHFEVSGEIWRASIELMKYGMALAKEADCAVQLHTESFTEEKFRELGKIVKEVGIKPYRVVKHYSPPLVKIAEEVGVFPSILASKKAMMEAIMQGNRFFMETDYIDDKRRPGAVLGPKTVPKRTKAFLQQRIFTEEDVYKIHVENPEKVYGVEMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHH0</accession>
    <name>F0LHH0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tungsten-containing aldehyde ferredoxin oxidoreductase cofactor modifying protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01322"/>
    <dbReference type="EnsemblBacteria" id="ADT84297">
        <property type="protein sequence ID" value="ADT84297"/>
        <property type="gene ID" value="TERMP_01322"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01322"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1323"/>
    <dbReference type="eggNOG" id="arCOG00938">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_1_1_2"/>
    <dbReference type="OMA" id="MCFKQYW"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027604">
        <property type="entry name" value="W_rSAM_matur"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04317">
        <property type="entry name" value="W_rSAM_matur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="337" mass="39295" checksum="1E78F3EB70249CE5" modified="2011-05-03" version="1">MCFKQYWEDEEGDMDYSLFLKILNDAEDFPELEMIYFGGIGEPTVHPRFMDMVREVKKRGYALGMSTNGFLLTDKVIKELVELETDLIYISLDTIPTQETRIGHIMPSVAVDRIKKIVEEKKRQKKDFPHIGVEVVVTKENYWQMAEIADYLGELGIDVLLFSNIIPIEKHQADQIVYDGSVDMQSHIDELHAKAYKHFLLKLPEFELRTERHCDFIEKKVAVVRWDGEVAPCYRFLHTYPEIIFGREKKVYAYSFGNVKQKSLKEIWTSRDYTWFRFIVKNSIYPSCTDCQLADSCSFVEDTNADCWGNTPSCGDCLWARRIVVCPIPEKGIKGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHI1</accession>
    <name>F0LHI1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aromatic ring hydroxylating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467606.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01333"/>
    <dbReference type="EnsemblBacteria" id="ADT84308">
        <property type="protein sequence ID" value="ADT84308"/>
        <property type="gene ID" value="TERMP_01333"/>
    </dbReference>
    <dbReference type="GeneID" id="10041649"/>
    <dbReference type="KEGG" id="tba:TERMP_01333"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1333"/>
    <dbReference type="eggNOG" id="arCOG01845">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091588_2_2_2"/>
    <dbReference type="OMA" id="PPWGPER"/>
    <dbReference type="OrthoDB" id="83611at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="107" mass="12199" checksum="ADABBF09D3969399" modified="2011-05-03" version="1">MDKAEEVKLSKEAILEKLKEVVDPEIGIDVVNLGLIYELEIRPDNTVYVKMTMTTPGCPLTMWLLKAVEEKILEIPGVKDAEIELTFDPPWSPERISEEYKKKLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHP2</accession>
    <name>F0LHP2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Archaeal ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466424.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83126">
        <property type="protein sequence ID" value="ADT83126"/>
        <property type="gene ID" value="TERMP_00149"/>
    </dbReference>
    <dbReference type="GeneID" id="10040467"/>
    <dbReference type="KEGG" id="tba:TERMP_00149"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.150"/>
    <dbReference type="eggNOG" id="arCOG03166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041137_3_0_2"/>
    <dbReference type="OMA" id="PYWVEED"/>
    <dbReference type="OrthoDB" id="21452at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="307"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="458" mass="54936" checksum="9D2AB034C0BCD9A1" modified="2011-05-03" version="1">MILKFINREGELKALEELYIQNRAHLILIYGRRRIGKTELIKQFIKDKPSFYFLARKQPIELELNRLIQNFNRKFNVFIEAHSLEEFFEKVKDFGRLVFVIDEFPYWVEEDKSIPSVFQYIWDEILKDSQIMLILLGSSISTMESLMSYKNPLYGRRTAQLKLSPIGFFHLKEVFPRYSWDELVKVYGCIDGIPAYFQHFDNSLSVEENIERNFYNKVSILYEDAERLLKDELREPIDYLNILKAINEGKTKLTEIANETKIAITNLPKYLKTLETLDLVYKEFPITQRERRKFGVYRVKDFYYRFWLRFVYPYKDDIEIGAISFEDFREDFNKYLGEVFEIVARQFLIKLNIESKLPFKFTKIGRWWDKEKEIDLVIINSITHEAGFFEVKWKELSYKDAIKILKELKEKRKSIKINTKAEHYGLIAKHADRKEELREKGYLVFDLSDFTSPQQPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHQ1</accession>
    <name>F0LHQ1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00158"/>
    <dbReference type="EnsemblBacteria" id="ADT83135">
        <property type="protein sequence ID" value="ADT83135"/>
        <property type="gene ID" value="TERMP_00158"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00158"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.159"/>
    <dbReference type="HOGENOM" id="CLU_3148151_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="48" mass="5401" checksum="EFE7771AE3837516" modified="2011-05-03" version="1">MGELIPLIVQGWTEQTNPELLDPNKDSPKILPPDHTKERAKNNPALQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHS0</accession>
    <name>F0LHS0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,5-diketo-D-gluconic acid reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466452.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00177"/>
    <dbReference type="EnsemblBacteria" id="ADT83154">
        <property type="protein sequence ID" value="ADT83154"/>
        <property type="gene ID" value="TERMP_00177"/>
    </dbReference>
    <dbReference type="GeneID" id="10040495"/>
    <dbReference type="KEGG" id="tba:TERMP_00177"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.178"/>
    <dbReference type="eggNOG" id="arCOG01619">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_2"/>
    <dbReference type="OMA" id="HCRFVNM"/>
    <dbReference type="OrthoDB" id="35652at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="278" mass="31946" checksum="81FFC0FE3F11C49A" modified="2011-05-03" version="1">MKRVIPFNDLKKIGDDKVTAVGMGTWGIGGRERADYSRDKESVEALRYGLDLGINLIDTAEFYGAGHSEEIVGNAIKEYERDSIFIISKVWPTNFGYEKAKKAARNSAKRLGTYIDLYLLHWPIDDFERIKETLWALEDLVDEGIIRYIGVSNFDLELLKRSQEVMRKHEIVANQVKYSLMDRRVERTGLLEYMKKENIALIAYTPLEKGQLARNPCLAKIGEKYSKTAAQVALNYLIWHENVIAIPKAINKEHLKENFGAMGWRLSEEDLKRARECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHS7</accession>
    <name>F0LHS7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83161">
        <property type="protein sequence ID" value="ADT83161"/>
        <property type="gene ID" value="TERMP_00184"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00184"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.185"/>
    <dbReference type="eggNOG" id="arCOG04026">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_205638_2_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007166">
        <property type="entry name" value="Class3_signal_pept_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04021">
        <property type="entry name" value="Class_IIIsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="58" mass="6525" checksum="1A2372359364735A" modified="2011-05-03" version="1">MRGQAAIEYLFMILLALLIVSLVIRYIKNIANEAGQTIENATRVLLRELQSSYSNIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHU6</accession>
    <name>F0LHU6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-phosphopantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphopantothenate synthetase</fullName>
            <shortName evidence="1">PPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27930"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal phosphopantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.36" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467644.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01371"/>
    <dbReference type="EnsemblBacteria" id="ADT84346">
        <property type="protein sequence ID" value="ADT84346"/>
        <property type="gene ID" value="TERMP_01371"/>
    </dbReference>
    <dbReference type="GeneID" id="10041687"/>
    <dbReference type="KEGG" id="tba:TERMP_01371"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1371"/>
    <dbReference type="eggNOG" id="arCOG04262">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078701_0_0_2"/>
    <dbReference type="OMA" id="PKSHPRY"/>
    <dbReference type="OrthoDB" id="76877at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02224">
        <property type="entry name" value="PPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002855">
        <property type="entry name" value="PPS/PS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038138">
        <property type="entry name" value="PPS/PS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40695">
        <property type="entry name" value="PTHR40695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02006">
        <property type="entry name" value="PPS_PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004853">
        <property type="entry name" value="UCP004853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="201"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="264" mass="29916" checksum="2D1F91AE00430D2D" modified="2011-05-03" version="1">MAEFKVPKSHPRYWSLYYRHKLEEALENGILATAGLIAHGRGEAFDYLIGEKTIEPAERAMRAAVAKLLLAEHPVLSVNGNVAALVPKETIELAKLLNAKIEINLFYRTEERVKAIAEVLREIDPDVELLGINPTKRIPNLESERGKVDEKGIWRADVVVVPLEDGDRTEALVAMGKFVITIDLNPLSRSARMADITVVDNIIRAYPRMIEIAKELKKKPKEELKAIVNNYDNGKILSEVLLHMKDRLEKLANHSIWRMKELPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHY1</accession>
    <name>F0LHY1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YHS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467679.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01406"/>
    <dbReference type="EnsemblBacteria" id="ADT84381">
        <property type="protein sequence ID" value="ADT84381"/>
        <property type="gene ID" value="TERMP_01406"/>
    </dbReference>
    <dbReference type="GeneID" id="10041722"/>
    <dbReference type="KEGG" id="tba:TERMP_01406"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1406"/>
    <dbReference type="eggNOG" id="arCOG04507">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185152_1_1_2"/>
    <dbReference type="OMA" id="GKIYYFC"/>
    <dbReference type="OrthoDB" id="128626at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="2">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="73" mass="8205" checksum="616C621DAFBD4537" modified="2011-05-03" version="1">MPIDPVCGMEIGEETEFKVEYGGKVYYFCSPHCKAQFEANPEKYIKEGGMEHGHGMHSHGHGHGHKKHGCCHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHY7</accession>
    <name>F0LHY7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467685.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01412"/>
    <dbReference type="EnsemblBacteria" id="ADT84387">
        <property type="protein sequence ID" value="ADT84387"/>
        <property type="gene ID" value="TERMP_01412"/>
    </dbReference>
    <dbReference type="GeneID" id="10041728"/>
    <dbReference type="KEGG" id="tba:TERMP_01412"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1412"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_0_0_2"/>
    <dbReference type="OMA" id="IKFFVTT"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="187" mass="21193" checksum="BA866F75C725BB7E" modified="2011-05-03" version="1">MDERDLLIYRLLRKNGRMKMSEIARELGISHPSARERLEKLERRGDLRVQALLNIRKRNFVSAVVNLKVRSMDEAEKLADVFARCPRTVFVATTTGKYNLNLALIAESYSALEATIENTIRPMESVKEMDVSLGSSPAYPEFVDFKLEPTRKVAPCGKVCTECYIYGRKCSGCLATVYFMGLKGSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI02</accession>
    <name>F0LI02_THEBM</name>
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        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">TERMP_01427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01427"/>
    <dbReference type="EnsemblBacteria" id="ADT84402">
        <property type="protein sequence ID" value="ADT84402"/>
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    </dbReference>
    <dbReference type="GeneID" id="10041743"/>
    <dbReference type="KEGG" id="tba:TERMP_01427"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1427"/>
    <dbReference type="eggNOG" id="arCOG00499">
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    </dbReference>
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    <dbReference type="OrthoDB" id="73329at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="36"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="251" mass="28874" checksum="88ADA0E213CD0981" modified="2011-05-03" version="1">MKVIVLGSGSYSGTPKPLCSCENCVRARKYPQHRRTRFSVFIPEIKALIDPSPDLHYHLEHLNMDVKRVFITHAHFDHIAGLPELQIFKGVKFYSHEYAVNTAKHLQELFLGERDWEYIPLEFNRWYDFGFRVYHFPTIHQPIKAAGGFVIEIGKKKIAITGDTGPEILGDENAIEIMKGSDLLIAEMTKKHSVPKTHLGVEDAIKLAQKVEAKKTVFAHISHSNYTQERLEDMVRDHGYIIARDFMYVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI44</accession>
    <name>F0LI44_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00221"/>
    <dbReference type="EnsemblBacteria" id="ADT83198">
        <property type="protein sequence ID" value="ADT83198"/>
        <property type="gene ID" value="TERMP_00221"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00221"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.221"/>
    <dbReference type="eggNOG" id="arCOG00701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_3_2"/>
    <dbReference type="OMA" id="YSVHVPI"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="12"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="247" mass="28192" checksum="E6A480BEC0ABD52F" modified="2011-05-03" version="1">MCIGTVISMSQTIVLGHGGFRDVYPENTIIAFEKAIEAGADGIEFDVWLTKDGKLVTLHDGKFRTNDEVYYIKELSLKSLRKFHPYGKFIPTVDELFEMFPNLIFNIDVKDKEAVKPLLKLVEEFDSFDRVIFSSPSPETLRLIRKHSKEAKLGFSIITETGIVKVALLKRNLKLYSLHVPLDGISYVGFPMFVALLKWVRGLGIKIFMWNYEMDELFWLPRLKGLYDGIIADNAVKVLNLIELGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIC4</accession>
    <name>F0LIC4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na+/H+ antiporter MnhB subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_01479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467752.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01479"/>
    <dbReference type="EnsemblBacteria" id="ADT84454">
        <property type="protein sequence ID" value="ADT84454"/>
        <property type="gene ID" value="TERMP_01479"/>
    </dbReference>
    <dbReference type="GeneID" id="26136967"/>
    <dbReference type="KEGG" id="tba:TERMP_01479"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1479"/>
    <dbReference type="eggNOG" id="arCOG03079">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101659_3_2_2"/>
    <dbReference type="OMA" id="INPGYLN"/>
    <dbReference type="OrthoDB" id="119875at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="8">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="156" mass="16603" checksum="EE45DEFE19BC457F" modified="2011-05-03" version="1">MTTTIIKTTTKILAPLILVFGSYIILHGHLTPGGGFQGGAVFASGLALLIVANKYDAVKSLFEKAPLSVFESIGALGFLGMACLGFAGYTFFKNVIANSGFPLFGGKTPVGINPGYLNTGGTLPYMNIFVGMKVLAGLTSIVLVFFLIMRRERDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LID8</accession>
    <name>F0LID8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane bound hydrogenase MbhF-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_01493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467766.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01493"/>
    <dbReference type="EnsemblBacteria" id="ADT84468">
        <property type="protein sequence ID" value="ADT84468"/>
        <property type="gene ID" value="TERMP_01493"/>
    </dbReference>
    <dbReference type="GeneID" id="10041809"/>
    <dbReference type="KEGG" id="tba:TERMP_01493"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1493"/>
    <dbReference type="eggNOG" id="arCOG03079">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101659_3_2_2"/>
    <dbReference type="OMA" id="GFLPIMN"/>
    <dbReference type="OrthoDB" id="119875at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="8">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="148" mass="15599" checksum="33127545C33A104F" modified="2011-05-03" version="1">MENDMGLIVKTMARATIPLIGIFGAYVVSHGHLTPGGGFQGGATIAGAGILFLIAFGLNEAKKRYDKNLYSALEGLGGLAFLGAAMLGLSVAFFYNILWRNRIAFAGQPGTLLSAGFLPIMNLAVGLKVFTGLVSAMMAIALFRRWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIE5</accession>
    <name>F0LIE5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467773.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01500"/>
    <dbReference type="EnsemblBacteria" id="ADT84475">
        <property type="protein sequence ID" value="ADT84475"/>
        <property type="gene ID" value="TERMP_01500"/>
    </dbReference>
    <dbReference type="GeneID" id="26137011"/>
    <dbReference type="KEGG" id="tba:TERMP_01500"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1500"/>
    <dbReference type="eggNOG" id="arCOG01641">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182721_0_0_2"/>
    <dbReference type="OMA" id="FMFREES"/>
    <dbReference type="OrthoDB" id="125987at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="75" mass="8161" checksum="036FF766705DD409" modified="2011-05-03" version="1">MYGDRFGGNRDRFGGVAPVKVGERYTVKIESIGKGGDGIARIKGFVVFVPNTKVGQEVEIVINSVKRKFAFGEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIG4</accession>
    <name>F0LIG4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466536.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00261"/>
    <dbReference type="EnsemblBacteria" id="ADT83238">
        <property type="protein sequence ID" value="ADT83238"/>
        <property type="gene ID" value="TERMP_00261"/>
    </dbReference>
    <dbReference type="GeneID" id="10040579"/>
    <dbReference type="KEGG" id="tba:TERMP_00261"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.261"/>
    <dbReference type="eggNOG" id="arCOG02579">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126379_0_0_2"/>
    <dbReference type="OMA" id="CPGINHP"/>
    <dbReference type="OrthoDB" id="85209at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="166" mass="19837" checksum="BB3701342F8D1035" modified="2011-05-03" version="1">MKKKWIATIHLDTLEIESDPSFKFKCLENCAECCFRLEVPLRDEDIERLEELGYSTWEFVDYEKMFYRGDRFLGYALKKRPFDGGCIFLQENGKCKVYPHRPLACKLYPFVLIRKGNTLEVYIKEDEFCKGINHPQGEPFTLELVKKYFWEIVEDYRRKLGFSEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIJ4</accession>
    <name>F0LIJ4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proton/glutamate symport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_00291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466566.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00291"/>
    <dbReference type="EnsemblBacteria" id="ADT83268">
        <property type="protein sequence ID" value="ADT83268"/>
        <property type="gene ID" value="TERMP_00291"/>
    </dbReference>
    <dbReference type="GeneID" id="10040609"/>
    <dbReference type="KEGG" id="tba:TERMP_00291"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.291"/>
    <dbReference type="eggNOG" id="arCOG04335">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019375_7_1_2"/>
    <dbReference type="OMA" id="YLYIAVI"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="428" mass="45204" checksum="7EAABA2BFA621CA2" modified="2011-05-03" version="1">MAQKGILRTYLDIPVLQKIFAGLILGVIVGLVLGSLGYADAVKTYIKPFGDIFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVIYYLLTSAFAVTLGIIMARIFKPGLGLQLATGAKFQAKQAPSMVQTLLNIIPKNPFGALANGQVLPTIFFAIVLGIALTYLMNSKDEFVKDSANTLFKAINGLAEAMYKIVGGVMQYAPIGVFALIAYVMAEQGVKVVGQLAKVVVAVYLGLILQIVLVYFVLLKIFGLDPIKFIKKAKDAMITAFVTRSSSGTLPVTMRVADEEMGISKGIYSFTLPLGATINMDGTALYQGVCTFFIALAIGQHLTIGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLQSVGLPLTDPSVAAAYAMILGIDAILDMGRTMVNVTGDLTGTTIVAKTEGELDLSKWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIP8</accession>
    <name>F0LIP8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="ordered locus">TERMP_01525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467798.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01525"/>
    <dbReference type="EnsemblBacteria" id="ADT84500">
        <property type="protein sequence ID" value="ADT84500"/>
        <property type="gene ID" value="TERMP_01525"/>
    </dbReference>
    <dbReference type="GeneID" id="10041841"/>
    <dbReference type="KEGG" id="tba:TERMP_01525"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1525"/>
    <dbReference type="eggNOG" id="arCOG01303">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_0_2"/>
    <dbReference type="OMA" id="YRDSHEW"/>
    <dbReference type="OrthoDB" id="96879at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="29"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="134" mass="14992" checksum="775D2388E029A921" modified="2011-05-03" version="1">MIEVGEYKVKEGLYYTKEHEWAQVLDDGTVLVGISDYAQKELGDVAYVELPEVGKEVSQGDVLCEIESVKAVSEVYAPVSGEVVEVNGELEDSPEKINEDPYEAWIAKIKPSNLEEDLKNLMTAEQYAEYLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIU3</accession>
    <name>F0LIU3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467843.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01570"/>
    <dbReference type="EnsemblBacteria" id="ADT84545">
        <property type="protein sequence ID" value="ADT84545"/>
        <property type="gene ID" value="TERMP_01570"/>
    </dbReference>
    <dbReference type="GeneID" id="10041886"/>
    <dbReference type="KEGG" id="tba:TERMP_01570"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1570"/>
    <dbReference type="eggNOG" id="arCOG02640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104916_1_1_2"/>
    <dbReference type="OMA" id="IWNQVIT"/>
    <dbReference type="OrthoDB" id="75689at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002727">
        <property type="entry name" value="DUF47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36536">
        <property type="entry name" value="PTHR36536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00153">
        <property type="entry name" value="TIGR00153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="215" mass="24829" checksum="4B0BD7CACEB6C214" modified="2011-05-03" version="1">MPIFGGKESNVFEAINRHLEMVGLTLEKLNEMIRIYLEGDFEKAEDLMREVENYEREADTLRREIETMLYQGAFLPANRGDYVRLSELIDNTADAAESAAHVLILAKPKVPKELKEEIMQLVDASLKTYEYVRKAVELLNEDVNEALEYAKKTEEQEENADKLEYDILKKMFESEKITTYAKLIWNQVITKIGDIADRAEDASDQVMLMAIKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIU5</accession>
    <name>F0LIU5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylornithine deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467845.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01572"/>
    <dbReference type="EnsemblBacteria" id="ADT84547">
        <property type="protein sequence ID" value="ADT84547"/>
        <property type="gene ID" value="TERMP_01572"/>
    </dbReference>
    <dbReference type="GeneID" id="10042563"/>
    <dbReference type="KEGG" id="tba:TERMP_01572"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1572"/>
    <dbReference type="eggNOG" id="arCOG01107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_0_2"/>
    <dbReference type="OMA" id="LNSHHDT"/>
    <dbReference type="OrthoDB" id="14646at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="163"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="367" mass="41124" checksum="A1902B31F238F85D" modified="2011-05-03" version="1">MEVELLKKLVSTPSHFGEEKEISEFITSFLEPYAKVETQEVEGFGSNVIAYLKGVKNTVVLNGHMDTVGLSAGWTKNPWGQIEGDKFYGLGSADMKGGLAALMSVFAEIAELSRRERPNVIFTAVVDEEGYSRGTWELIKSKKLEKADVVLVGEPTNEKLMLGARGRFVIQVKAFGKKAHAARPENGINAIEELSKLLANLNRAKLKKHRKLGKGSFCTLEIEGKADGLSVPEYAKAIVDRHTVVGEDWEFVRETLEKLAQKLEIKAKLKIEKFKRPTPEMLPYYVKENLKVVKIFKRIFKQKTGKDVEVTYGKSVGDFNYFGTYLGKPTLVFGPIGGNWHSADEWVSISSVKRVKEIYRDFLKALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIW7</accession>
    <name>F0LIW7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="3">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobB</name>
        <name evidence="5" type="ordered locus">TERMP_00336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">2 residues (Tyr-85 and Arg-88) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00336"/>
    <dbReference type="EnsemblBacteria" id="ADT83313">
        <property type="protein sequence ID" value="ADT83313"/>
        <property type="gene ID" value="TERMP_00336"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00336"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.336"/>
    <dbReference type="eggNOG" id="arCOG04248">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_1_2"/>
    <dbReference type="OMA" id="SMQVYPA"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
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    </dbReference>
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            <begin position="24"/>
            <end position="272"/>
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            <begin position="41"/>
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        </ligand>
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            <position position="148"/>
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            <begin position="212"/>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="272" mass="30618" checksum="CAF54DB46BA9E0CC" modified="2011-05-03" version="1">MMDITYVKILKPKIRKILGNGMIEEAAKIIARSRFLIAFTGAGISAESGIPTFRGRNGLWKRHRPEELATPEAFARNPKLVWEFYRWRMKIISKAKPNKAHLVLAELERMGILKAVITQNVDDLHREAGNKNIIELHGNIFRVKCIRCDYRENLKESGRLEKFLEDEDLPKCPKCGSLLRPDVVWFGEALPESALSKAFSLARRADVCLVVGTSGQVFPAAYIPYIVKDNGGYVIEINPSQSGITPIADIFIRGKAGEVMDELLKKVEELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
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            <dbReference type="PubMed" id="21217005"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
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        <property type="entry name" value="MIP18-like"/>
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        <property type="entry name" value="SSF117916"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="117" mass="13460" checksum="9569AD03EECB597F" modified="2011-05-03" version="1">MKIYSPDREYPPEYREVLEELKKIIDPVTGGDILDSGVVAGLEVTKDTLKIWLRFESHAEYNIIGESPIAYSKIIGDIMERFALVKFDNVYVYDLGNKIVGKFENKGRYKPEDLREG</sequence>
</entry>
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        <submittedName>
            <fullName evidence="2">Circadian clock KaiC-like protein</fullName>
        </submittedName>
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        <name evidence="2" type="ordered locus">TERMP_00364</name>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83341.1"/>
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    <dbReference type="STRING" id="391623.TERMP_00364"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="KaiC-like_dom"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="231" mass="26262" checksum="5B931A6E787F2A19" modified="2011-05-03" version="1">MTRISTGVKGLDKMLNGGLIPGRAYLVKGGPGSGKTTLCIHFLMEGVKRGEKVLYITLEEPIDILKEDMREMGFDVDNPLFVGIDATPVKEKRSFFEGMHYEEFAKGFNELIRAIKERLEGEEFTRVVIDPITMIKLTMKDELEYRRTFLGFLKEIAKYNVTLLITSEIYEMGIEDYLVSGVIELRTFEVGGKTVRGIKVVKFRGSDFDETIRPYKITGNGIEVYSEETIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIZ8</accession>
    <name>F0LIZ8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466642.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00367"/>
    <dbReference type="EnsemblBacteria" id="ADT83344">
        <property type="protein sequence ID" value="ADT83344"/>
        <property type="gene ID" value="TERMP_00367"/>
    </dbReference>
    <dbReference type="GeneID" id="10040685"/>
    <dbReference type="KEGG" id="tba:TERMP_00367"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.367"/>
    <dbReference type="eggNOG" id="ENOG502N572">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1465186_0_0_2"/>
    <dbReference type="OrthoDB" id="128097at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="184" mass="20727" checksum="666A09158FABB27D" modified="2011-05-03" version="1">MICPIIREVVEIVIGFSVISLYFSKRFPLMYKSHLALAIGAFFLSEPILDYLFGMDSTILEFIGALLLLWVVERFIAVNKNSRISFYTLIIGGFAGVLGFALNKNLAYFHIGTLTAFAFISLRMGKAVEVVRWEHRDVFLISSIFLFAGAIAFASALFMLSLFLYYGGIFIFMLAVMEIMHGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ21</accession>
    <name>F0LJ21_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466665.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00390"/>
    <dbReference type="EnsemblBacteria" id="ADT83367">
        <property type="protein sequence ID" value="ADT83367"/>
        <property type="gene ID" value="TERMP_00390"/>
    </dbReference>
    <dbReference type="GeneID" id="10040708"/>
    <dbReference type="KEGG" id="tba:TERMP_00390"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.390"/>
    <dbReference type="eggNOG" id="arCOG01359">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533842_0_0_2"/>
    <dbReference type="OMA" id="HTPGKYL"/>
    <dbReference type="OrthoDB" id="19362at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="196"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="581" mass="65604" checksum="E8937127F9EA6E92" modified="2011-05-03" version="1">MIVAIVDGYTDEPAGLGVPPYLGIYPRYAYGAIKKARKDAQIFYLTIDDLRFTFEGEQGIKTKNKTPNVFKVREILSKADLIVYIGGLHTPGKYLSAVPSQVEEVARFLKHFNGTKILGGPAFMGSAHEGGTRISSRELMLADQIFDHIVYGDLEAFLYDLLTTPKDADPFRFRTYGELRDYALLGAEVVKQFPDYPEFVIVEIETQRGCPKAMGIGGCSFCTEPVRYKRVEDRPIGDIVEEIKVLYDLGVRHFRVGRQSCIFSYMAEPNGRVPVPNPEAVEKLFKGIREAAPNIKTLHVDNANPAVIANYPEESIKIAKALIKYGTPGNVVAFGLETADPKVAKRNNLNTTAEETYEAVKILNEIGAKRGYNGMPWLLPGINIIFGLPGETKKSYEITFQFLKRLVDDGLMVRRINIRQVVVFPGTPLWFMKDKVKTEKHKHLIKHYKYKIRHEIDLPMLKRVAPVGTILRDVRAEVYENGLTYGRQIGSYPLIVGIPKQIKLNKFYDVLIVDHGFRSITGIPIPINVNKESSKVLSYLPGIGRKRVTKILTKRPFKSKEEFLALLDKDLKEMYREIVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ52</accession>
    <name>F0LJ52_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01599"/>
    <dbReference type="EnsemblBacteria" id="ADT84574">
        <property type="protein sequence ID" value="ADT84574"/>
        <property type="gene ID" value="TERMP_01599"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01599"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1599"/>
    <dbReference type="eggNOG" id="arCOG00157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_2"/>
    <dbReference type="OMA" id="IIATMQV"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="208" mass="23689" checksum="8902602565396E3E" modified="2011-05-03" version="1">MGLLLAIMLDRRIRFESGFRTIYALPFALSFVVTATLWAWMYDPSSGVLNTIFGKLHLEFLKSRWITDPKIAMYCIIIALIWQFSGYTMIIYLAGIRSIPVDHYEAAVIDGASTWQLYRYVVIPQLVKPTLSAFVVLMVFSLKAFDFIWVLTRGGPGTSTFILAVQMYKETFAKTNFAYGAAIATILLLMALAIVLPYLYWSYRGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ68</accession>
    <name>F0LJ68_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84590">
        <property type="protein sequence ID" value="ADT84590"/>
        <property type="gene ID" value="TERMP_01615"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01615"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1615"/>
    <dbReference type="HOGENOM" id="CLU_3264015_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="41" mass="4819" checksum="D2A99E8C7427812A" modified="2011-05-03" version="1">MNLVFYVISAAVLIAVLYAMEKRKELSEFTNRILKLVFRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ75</accession>
    <name>F0LJ75_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA/RNA cytosine-C5-methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467895.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01622"/>
    <dbReference type="EnsemblBacteria" id="ADT84597">
        <property type="protein sequence ID" value="ADT84597"/>
        <property type="gene ID" value="TERMP_01622"/>
    </dbReference>
    <dbReference type="GeneID" id="10041938"/>
    <dbReference type="KEGG" id="tba:TERMP_01622"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1622"/>
    <dbReference type="eggNOG" id="arCOG00974">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_0_1_2"/>
    <dbReference type="OMA" id="HAYVFEI"/>
    <dbReference type="OrthoDB" id="32049at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="6">
        <location>
            <begin position="179"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="269"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="451" mass="52796" checksum="164429326A2A4A3A" modified="2011-05-03" version="1">MELFYRITLHELIADILTLIDERELSSKNALERVFKRVSGKDREKARGLAHAYVFEIEKWRKKIDFIVNSVLKGSKIEDLELYLANLIRIGVFEMKFKGVNPAIATDSVVRVVKEKYDLAKAKFVNALLREVENFNLEKALKKLKEKDRIEYLSVKFSHPRWYVEYAIELLGYDDAIRLLLSNNRAQRYYVRVNPIKTDIDSLADYLEEHNVRVARTPVDDVLKILEYKTPITRLEWYKQGYFVIQDLASAYVAHVLGPEKGERILDLAAAPGSKTFHVAHLMENTGEIIAVDYSLERLNKMREKMKILGVRNVKLVHADGMKFKEKEEFDRIILDAPCSSSGTYRQFPEVKWRFDERKIKKVIQVQKAMLRNAYRNLRIGGEMTYSTCSIRIDENEENIKYAMNKIGFELVDYPFSWGERGFLEIGDKVFRAWTHLHDCNSFFIAKLRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ84</accession>
    <name>F0LJ84_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467904.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01631"/>
    <dbReference type="EnsemblBacteria" id="ADT84606">
        <property type="protein sequence ID" value="ADT84606"/>
        <property type="gene ID" value="TERMP_01631"/>
    </dbReference>
    <dbReference type="GeneID" id="10041947"/>
    <dbReference type="KEGG" id="tba:TERMP_01631"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1631"/>
    <dbReference type="eggNOG" id="arCOG00132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025894_0_2_2"/>
    <dbReference type="OMA" id="IPYLNLY"/>
    <dbReference type="OrthoDB" id="32618at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MFS" evidence="1">
        <location>
            <begin position="12"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="397" mass="43630" checksum="4B2172CBFCA79FD0" modified="2011-05-03" version="1">MSLEKYRGFSRDAKLVVAYSFFGWLGGNIAWFILPFYLKSLGMDFTKIGILFSLSTIVQAALLLISGQISIRFGYKRTILLSLSLIFIARLIQVSVPVFWALALSSVIAGIAMALEWPSLMALLSGEASEEKRHYLFTLNSALGTAGAAFGMLLGGILPKVLDGTNPYRRTLLLAALLILIQMVLMSFVSPVLGKEERKLRLRRELLIKIAKFSLPSALIGLGAGVTIPYMGLYFNLKFGTSLESIGGLFALQQLVMALGMFSMPLLADKIGSVKTIVSFNGSATALIIALPLAPSFLIASIIYIVRTILMNIVNPIWDAFMMKFFTKEERATSIALRSFAWTSTFGLGQYLGGIIFDRSLVFPFLITGFLYAASIVIFWMFFAGYEERVISNGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ90</accession>
    <name>F0LJ90_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467910.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01637"/>
    <dbReference type="EnsemblBacteria" id="ADT84612">
        <property type="protein sequence ID" value="ADT84612"/>
        <property type="gene ID" value="TERMP_01637"/>
    </dbReference>
    <dbReference type="GeneID" id="10041953"/>
    <dbReference type="KEGG" id="tba:TERMP_01637"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1637"/>
    <dbReference type="eggNOG" id="arCOG05768">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115257_0_0_2"/>
    <dbReference type="OMA" id="FEMFFWG"/>
    <dbReference type="OrthoDB" id="78702at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="210" mass="24241" checksum="EB6BCD0206399C31" modified="2011-05-03" version="1">MAYYQHAPEYGAYIFMMLSYFIFSWAIIILGAYINRGVLIKNPKFEDIPHGKKVFLKKWAPWLIIGLMLWSFSTFKLTDYYLSTYSFEFTGTHFTASSLLEDMRGNERYRFDVEGIQKLGMPHYGLLKGYKLQDSVREGLIVKRINQVVILQGYPFLPVAKLYIYDVAGKQVKSLRTAYIFFPQSPGGKLSSLFNFPFEMFFWGSGGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ93</accession>
    <name>F0LJ93_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467913.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01640"/>
    <dbReference type="EnsemblBacteria" id="ADT84615">
        <property type="protein sequence ID" value="ADT84615"/>
        <property type="gene ID" value="TERMP_01640"/>
    </dbReference>
    <dbReference type="GeneID" id="10041956"/>
    <dbReference type="KEGG" id="tba:TERMP_01640"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1640"/>
    <dbReference type="eggNOG" id="arCOG02642">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041771_2_0_2"/>
    <dbReference type="OMA" id="EIAYVYQ"/>
    <dbReference type="OrthoDB" id="79655at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="327" mass="36698" checksum="8B7EEDFC4ACC72DB" modified="2011-05-03" version="1">MKAELLVWGGIVIAILYLAWSTVSQLLSPIFFAAILTYAVYPIHKHLSSRLSIKKSALILTAFLILIATGITIELILIFKNVLMSFYEDVIAFISWSQTFTFPFGLTNVIQKFYAQFTPKFSEYILSYTFSIPKYLLQLVIFVVMFYYFLVSSEAIRRQISLLLPQENKELANKLLKRADLTLQALIRAWLLLNIAKGILMTLGFIVFQVSDVPTAVIAGFLTVLFSFVPLFEGWMIWLAGAIYLFKNGNVITAILLAVYGFVFVSPLPDFTVRPKLVAKGAQLDEVMVLVGMIGGAWSFGVKGLIIGPIVLNLVVALLKEWRKITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ98</accession>
    <name>F0LJ98_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Indolepyruvate oxidoreductase subunit IorA</fullName>
            <shortName evidence="13">IOR</shortName>
            <ecNumber evidence="3 13">1.2.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Indolepyruvate ferredoxin oxidoreductase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">TERMP_01645</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:12645"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57271"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="EC" id="1.2.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 13">Heterodimer of the IorA and IorB subunits.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.8" evidence="3 13"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467918.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01645"/>
    <dbReference type="EnsemblBacteria" id="ADT84620">
        <property type="protein sequence ID" value="ADT84620"/>
        <property type="gene ID" value="TERMP_01645"/>
    </dbReference>
    <dbReference type="GeneID" id="10041961"/>
    <dbReference type="KEGG" id="tba:TERMP_01645"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1645"/>
    <dbReference type="eggNOG" id="arCOG01609">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017727_0_0_2"/>
    <dbReference type="OMA" id="VTMKQVG"/>
    <dbReference type="OrthoDB" id="20764at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043805">
        <property type="term" value="F:indolepyruvate ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017721">
        <property type="entry name" value="IorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="PTHR43710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006439">
        <property type="entry name" value="Indolepyruvate_ferr_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03336">
        <property type="entry name" value="IOR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="15">
        <location>
            <begin position="551"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="15">
        <location>
            <begin position="582"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR006439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR006439-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADT84620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="616" mass="67924" checksum="E5D4323635E2F3CB" modified="2011-05-03" version="1">MRKLLMGNEAIAYGALESGISFATGYPGTPSTEVIETIARLNPEVFAEWAPNEKVALEEAAGVSYAGLRSLVTMKCVGLNVAADPLMSLAYSGVEGGLVILVADDPGPHTSQTEQDDRYYGKLSLLPVLEPYDPQEAHDLIKYAYGLSEKYKVPVLFRTTTRVNHTTADVEVGEFIKLERKPVFKKDIQRYVRASMKGNLERHKWLNKTLREIEKEFETLKFNWVEGEGRIGIIAEGAPYNYVKEVVPKIGENFKILKFSTPHPLPKKLVVDFLKSVDMVIVVEDGAPFLEEEVKIVAYEEGLNVPIYGKRTGHLPLEGELTPSLVRNALLKLLGKEAQSYEKPKEVKEAEKLAPSRPPTMCPGCPHRGSYRALLDALRELKFKRDEIPIHGDIGCYALSLLPPLEAIWTEYVMGASISLANGQSIAFGKKIVATIGDSTFFHNGIQPLVDAVYKNLDVLVMILDNRTTAMTGHQPHPGTGGSETGRKFNEIDIEALVKALGVKYVKTVDPYDLKATREAIKEAMQVKGPAVIIAKRECIIPVIRRGEIGETPTVIEDKCVGCKACILLTGCPALVYDPETNKVRIDPLICTGCGICNQLCPFEAIKFPSEIGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJA2</accession>
    <name>F0LJA2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467922.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01649"/>
    <dbReference type="EnsemblBacteria" id="ADT84624">
        <property type="protein sequence ID" value="ADT84624"/>
        <property type="gene ID" value="TERMP_01649"/>
    </dbReference>
    <dbReference type="GeneID" id="10041965"/>
    <dbReference type="KEGG" id="tba:TERMP_01649"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1648"/>
    <dbReference type="eggNOG" id="arCOG01084">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04332">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1109552_0_0_2"/>
    <dbReference type="OMA" id="NEEKYPA"/>
    <dbReference type="OrthoDB" id="67620at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11537">
        <property type="entry name" value="NTP-PPase_RS21-C6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025984">
        <property type="entry name" value="DCTPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12643">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="125"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="249" mass="28617" checksum="EEC814548299A1E5" modified="2011-05-03" version="1">MNFKELEEKAVKFRDERLWRKYHTPKNLAISITVEVGELLEHFQWDTNEEILEKVKNPKIKEEIGDEIADIIIYLTLLAHELGIDLDEAVERKLKKNEEKYPAREIRLQEIVEELGGEIIEVGKEVRSVKQVTKLLRVKPEQVVKSLVFISEKEPILVIVDGKSKASVEKLTKYFGRVRMANKEEVEKITGYKVGEVPPVGISIRTIVDKKVLEKDVVIAGGGRIDRLIKIKPEKILEFQKGEVLDIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJC5</accession>
    <name>F0LJC5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA primase large subunit PriL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">priL</name>
        <name evidence="8" type="ordered locus">TERMP_01672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467945.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01672"/>
    <dbReference type="EnsemblBacteria" id="ADT84647">
        <property type="protein sequence ID" value="ADT84647"/>
        <property type="gene ID" value="TERMP_01672"/>
    </dbReference>
    <dbReference type="GeneID" id="10041988"/>
    <dbReference type="KEGG" id="tba:TERMP_01672"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1671"/>
    <dbReference type="eggNOG" id="arCOG03013">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_691913_0_0_2"/>
    <dbReference type="OMA" id="KNIWYHL"/>
    <dbReference type="OrthoDB" id="29893at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06560">
        <property type="entry name" value="PriL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00701">
        <property type="entry name" value="DNA_primase_lrg_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023642">
        <property type="entry name" value="DNA_primase_lsu_PriL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0639">Primosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="398" mass="46370" checksum="54471B5F51795B82" modified="2011-05-03" version="1">MLDPFGKKARELLKEFEDINSFLEIIPTYLDINLALERVKWLKNGAIPEYILNANDWKDLMGFYALLGALAFSPYGFEMELVKEANLKIYLTRIEKTKNFEELSISIEPVADNEIPQRDLTIIEKRLYSEISPEDREKITLKYKVKLKDFLSLNEGSLKDVYIRNGYAYLNRSQLIELWEKSFEKNLERAVNLLYELRDELPQYYIQLYNRLSEIAREHFKKRLEGVGRTTAQPLRFDLFPPCIKIALGGVPSGLRNYAITVLLTSFLSYARICPNPPSKNVRIKDCIKDLSIIEKEILPVIIEAGNRCSPPLFEDQPNEIKNIWYHLGFGYTSKPKLEDSGTSTWYFPPNCSKIKVNAPQLCKPDKDCKYIKNPLTYYLRKLYLESKKESQGEDRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJC9</accession>
    <name>F0LJC9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466693.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00418"/>
    <dbReference type="EnsemblBacteria" id="ADT83395">
        <property type="protein sequence ID" value="ADT83395"/>
        <property type="gene ID" value="TERMP_00418"/>
    </dbReference>
    <dbReference type="GeneID" id="10040736"/>
    <dbReference type="KEGG" id="tba:TERMP_00418"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.418"/>
    <dbReference type="eggNOG" id="arCOG01053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_4_1_2"/>
    <dbReference type="OMA" id="WHVIKID"/>
    <dbReference type="OrthoDB" id="73908at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="45"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="221" mass="24503" checksum="31E8227CFE7778D2" modified="2011-05-03" version="1">MSESLIHLVLSDKLKEMLSGVNNFHLNSSMTCLEILKAVIAKKRENDVIILSKGHSAPAFYVILSGLGLLSEDELKSFANLDGLPSHVIRGFPFIEVSSGSLGQGLSVANGIALASKLEGEERNVYVILGDGELDEGQIWEAAMTSSHYRLDNVIAIVDRNFRQLTGMTEEIMSKEPLAEKWNSFGWEVFEVENNAEKLLKLLFELDKVKGKPKVIIAKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJD5</accession>
    <name>F0LJD5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Shikimate kinase</fullName>
            <shortName evidence="8">SK</shortName>
            <ecNumber evidence="5 8">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroK</name>
        <name evidence="10" type="ordered locus">TERMP_00424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="5 8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466699.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00424"/>
    <dbReference type="EnsemblBacteria" id="ADT83401">
        <property type="protein sequence ID" value="ADT83401"/>
        <property type="gene ID" value="TERMP_00424"/>
    </dbReference>
    <dbReference type="GeneID" id="10040742"/>
    <dbReference type="KEGG" id="tba:TERMP_00424"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.424"/>
    <dbReference type="eggNOG" id="arCOG01025">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073768_0_0_2"/>
    <dbReference type="OMA" id="WDVLVWT"/>
    <dbReference type="OrthoDB" id="98200at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00370">
        <property type="entry name" value="Shik_kinase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010189">
        <property type="entry name" value="SK_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF3">
        <property type="entry name" value="PTHR20861:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005758">
        <property type="entry name" value="Shikimt_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01920">
        <property type="entry name" value="Shik_kin_archae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="75"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="271" mass="29058" checksum="220077C17FFE2949" modified="2011-05-03" version="1">MKSEAFSAVTVINAFATGKGGAIGIDLKVSVGVKLTGEGVSGEIFVRGEKFEDFSLVGTVVETIKDKFGLDFGVKVKIDSEIPVGKGLKSSSAVANALTDAILKELKIELSDIEVVKLGVEASKRAGVTLTGAFDDACASYFGGLCLTDNLKLELLKKEEVEKLPVVLLIPKEILLTSSLRGRNFKVLAPYVEEAFKLALRGEWKKALVLNGLIYGSFLGYNLEPIVEALRAGVVAGLSGKGPAMFAITEEPEKIVETWRDYGEVLTTRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJF2</accession>
    <name>F0LJF2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00441"/>
    <dbReference type="EnsemblBacteria" id="ADT83418">
        <property type="protein sequence ID" value="ADT83418"/>
        <property type="gene ID" value="TERMP_00441"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00441"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.441"/>
    <dbReference type="HOGENOM" id="CLU_3338669_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="37" mass="4373" checksum="343ED3A1C46789A2" modified="2011-05-03" version="1">MRCLKMRELRVNSKRSISLEGEVEFSIALLVSYCHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJG9</accession>
    <name>F0LJG9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466733.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00458"/>
    <dbReference type="EnsemblBacteria" id="ADT83435">
        <property type="protein sequence ID" value="ADT83435"/>
        <property type="gene ID" value="TERMP_00458"/>
    </dbReference>
    <dbReference type="GeneID" id="10040776"/>
    <dbReference type="KEGG" id="tba:TERMP_00458"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.458"/>
    <dbReference type="eggNOG" id="arCOG02005">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055360_1_0_2"/>
    <dbReference type="OMA" id="TNTMHLI"/>
    <dbReference type="OrthoDB" id="74879at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF7">
        <property type="entry name" value="PTHR21198:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="226" mass="25889" checksum="173BD26D92F7B456" modified="2011-05-03" version="1">MKKIGIIGGMSPESTLYYYKKFIEISREKFEPYFYPELIIYSINFREFKDNPEGWEGRKKILINAAKALERAGAEVIGISANTSHIVFPDVQRAVNVEMVSIIDAVAEEAKRRGLRKLLLLGTKTTMTMSFYKEALKEKGFDVIVPSENEIEEINRIIFEELMFENLNSKLWLIELIERYVERREIEGVILGCTELPLAIKPEDVSAEVLDTAEIHVRALIEKALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJM5</accession>
    <name>F0LJM5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467965.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01692"/>
    <dbReference type="EnsemblBacteria" id="ADT84667">
        <property type="protein sequence ID" value="ADT84667"/>
        <property type="gene ID" value="TERMP_01692"/>
    </dbReference>
    <dbReference type="GeneID" id="10042008"/>
    <dbReference type="KEGG" id="tba:TERMP_01692"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1691"/>
    <dbReference type="eggNOG" id="arCOG00046">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014190_0_0_2"/>
    <dbReference type="OMA" id="GYTTNCL"/>
    <dbReference type="OrthoDB" id="25986at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012121">
        <property type="entry name" value="ATPase_PP-loop_MJ1599"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036668">
        <property type="entry name" value="ATPase_UCP036668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="274" mass="31703" checksum="C7E0820A91342061" modified="2011-05-03" version="1">MLTCSVCINNEKTSKIKIVNGKPICKECIVYLSHKPDKSKIQAELEELMKDVDKAIVAFSGGKDSTVALYLAKEVYKVPELEAVMIDHGFMAGEAIENAKRIAEYLNVQFTILRYDYSDIFREAFLKAQSPCRRCSKRTMEKLRRYALKKGVKYIITGHELPFGHHPYRLMSGGIIQIRLLSLMSESERFEILEKLPFEFPNLAGYTTNCLILGPALERYYEKHSFSFEHRRIAALVRYGLLDRKKALEKVKKPEIPEEIKRTVYERLNLEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJN1</accession>
    <name>F0LJN1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type ATP synthase subunit C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">V-ATPase subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atpC</name>
        <name evidence="6" type="ordered locus">TERMP_01698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467971.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01698"/>
    <dbReference type="EnsemblBacteria" id="ADT84673">
        <property type="protein sequence ID" value="ADT84673"/>
        <property type="gene ID" value="TERMP_01698"/>
    </dbReference>
    <dbReference type="GeneID" id="10042014"/>
    <dbReference type="KEGG" id="tba:TERMP_01698"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1697"/>
    <dbReference type="eggNOG" id="arCOG02459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059311_0_0_2"/>
    <dbReference type="OMA" id="WKYTPYS"/>
    <dbReference type="OrthoDB" id="75042at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00314">
        <property type="entry name" value="ATP_synth_C_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014272">
        <property type="entry name" value="ATPase_V0-cplx_c_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_su_c/d_dom_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02923">
        <property type="entry name" value="AhaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="2 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="370" mass="43031" checksum="DB785F7A25F936F5" modified="2011-05-03" version="1">MEISTITGILDTTLAVIFTWIAYKTGSIIYKYTPYSYPNARIRAMEARLFTEQRFNELAESKDLNTFVMNLEDSDYKPYLSKLSIYTAETIDRAFDEALADTYRLMFKILPKRINPFFKLLLEEWDIRNISAIVKAKVYGEVARDYIAELGTMVEKIKAMAEAKTLEEILVILEGTEYEEVYQRLLLKEITIEEFETELYKMHYAKLLKYAESRKDEERKILEEFVKLKIDKINLMTILRAKLYGLGADKIRPFLIPGGSLSQRVLDTLMHVEDLSMALAELDSTKYNEVLREVREGLESGDLDVFNKAFERYIKRKISELTRFYPLSVAIPLNYILAKESEIRKLKAIAKLIEDRIKPEDIKALVGELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK18</accession>
    <name>F0LK18_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biotin ECF transporter substrate-specific component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BioY family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01755"/>
    <dbReference type="EnsemblBacteria" id="ADT84730">
        <property type="protein sequence ID" value="ADT84730"/>
        <property type="gene ID" value="TERMP_01755"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01755"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1754"/>
    <dbReference type="eggNOG" id="arCOG02986">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077931_3_1_2"/>
    <dbReference type="OMA" id="AGYLWSY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="203" mass="21770" checksum="88821308705F3A24" modified="2011-05-03" version="1">MRLEKIDLFSKFFFREVKILKVNQNKTLEDAKMKAKEIAYSALFAALTAVGAQISIPIGEVPVTLQVLFVLLSGLILGARLGFLSQAIYLLMGAIGLSVFAGFKGGFVYLYGPTGGYLIAFPVAAFLVGLISERYENLKGYILGSLTGIGVIYLLGWLRLGFYFGGNFGKAFAVGVAPFVVIDLIKAGVAVVVADRVKKSGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK70</accession>
    <name>F0LK70_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-layer domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468078.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01807"/>
    <dbReference type="EnsemblBacteria" id="ADT84782">
        <property type="protein sequence ID" value="ADT84782"/>
        <property type="gene ID" value="TERMP_01807"/>
    </dbReference>
    <dbReference type="GeneID" id="10042123"/>
    <dbReference type="KEGG" id="tba:TERMP_01807"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1806"/>
    <dbReference type="eggNOG" id="arCOG02079">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03418">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_320984_0_0_2"/>
    <dbReference type="OMA" id="INDGKWK"/>
    <dbReference type="OrthoDB" id="3317at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="894"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="916" mass="101544" checksum="3685AF3C0AA2EE66" modified="2011-05-03" version="1">MKKFGILLGVMIIVATFNMVLAQDTVLFEGYLNKGDAILVGPLIITLNDVQKDYLTNQYKAMFVIMKDGKIINANYTVIYVPNPSKIQSLLEDPQFLRAMAETLGYNATNPLSYAQFLAWLATASPEEIADAVFKTINEHPELGINKEDILMPMRVPQFTYIGENETIELNVDGQKVTITALEIYPNGARISISGPYEWKASLIPALITTSIEAPKSVNPGQEFTVKVHLKNEGALKAKYITVMVSPVMLNVGSGENQSSTGQALAQALSQSGVVQSALMPVNTSIKYIEFLDGKESATLEFKFKANENAQPGVYPLYVTVIYFFGVGQNIRQMQSFNFVGITVARDSDASFVIESIEKPKIVHPGEDFEVKIKLRNMGGDTAKDFLATIEPKGSLNIEEQRIQNAQLPQSNLPMEAKTPILVANRTDQYYRAIVEPNEEVELTFRLHVSEDAETGSYPVTLKLTYYSGDSKDSKSQSFEFSVQVLRKREAFIEIESIDMEPKKIEPGDEFTLTIKLRNVGEENARAFVLKIIPTQVPVQGEIKKVDLSSLQNLPIQGSQAISENLQEALNQILKELAKRNVDAFLPIGEDNVKYVPEIAPNQEVTLTFHLKANDRLENGIYPLRIGVEYLSSPDDSKISDERLIGISVLGKEQLIISKVSTSPSRVYPGMHNVEVSLSVENIGSGEAKYVLLIPKPQSPFELSDTSEQIINLGTLRQGDSANAVFRINVNEDARGGSYKLPIEIQYKDALGNSQKIMLNVPIIIHEKPKLVVENVRFDKTPMQGEEIKVYITVKNVGGEKASSVMIEGIVKSSQPFTLTKRTDYIGNLKPGQSGEGVVELSIDKDAVPKTYVIQIRMRAVGDKESGDDNVYVFEDSIKIPVEENTKQAHTLKYAGMGVGFLVVLAILATYMKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK73</accession>
    <name>F0LK73_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH-type transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GbsR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468081.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01810"/>
    <dbReference type="EnsemblBacteria" id="ADT84785">
        <property type="protein sequence ID" value="ADT84785"/>
        <property type="gene ID" value="TERMP_01810"/>
    </dbReference>
    <dbReference type="GeneID" id="10042126"/>
    <dbReference type="KEGG" id="tba:TERMP_01810"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1809"/>
    <dbReference type="eggNOG" id="arCOG02795">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107445_2_0_2"/>
    <dbReference type="OMA" id="MYMRDEM"/>
    <dbReference type="OrthoDB" id="90861at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026282">
        <property type="entry name" value="MJ1563"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006707">
        <property type="entry name" value="MJ1563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH marR-type" evidence="3">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="98"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="175" mass="20394" checksum="9E442FFD95B25AA8" modified="2011-05-03" version="1">MGIEEARRIMMNHFANAARRFGLSELYGYIYGVLFFADEPLSLGEIAEKTGYSISHVSSALKLLESVGLVTRIKKPGDKKAYFTAIKNLKEWRKAAYYNKLLEDVRQTRVNVQKALEEIKEDKSEEAEKIREKLKFMLKRNEITEKIIKLLVRSDEERLLEKLILCLHELENERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKA7</accession>
    <name>F0LKA7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0145 protein TERMP_00588</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466863.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00588"/>
    <dbReference type="EnsemblBacteria" id="ADT83565">
        <property type="protein sequence ID" value="ADT83565"/>
        <property type="gene ID" value="TERMP_00588"/>
    </dbReference>
    <dbReference type="GeneID" id="26135866"/>
    <dbReference type="KEGG" id="tba:TERMP_00588"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.589"/>
    <dbReference type="eggNOG" id="arCOG02287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117144_1_2_2"/>
    <dbReference type="OMA" id="VDFEISM"/>
    <dbReference type="OrthoDB" id="121009at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="109" mass="11659" checksum="4E30DBEF08E1E60B" modified="2011-05-03" version="1">MDEFIVATTEHVPGYKVVKVLGIARGATVRAKHIGKDILAGLRNIVGGEVKEYTEMLAEAREVAIQRMIEHAKSMGANAVIGVRFMTSSIAAGAAEIFAYGTAVILEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKC8</accession>
    <name>F0LKC8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_00609</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466884.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00609"/>
    <dbReference type="EnsemblBacteria" id="ADT83586">
        <property type="protein sequence ID" value="ADT83586"/>
        <property type="gene ID" value="TERMP_00609"/>
    </dbReference>
    <dbReference type="GeneID" id="10040927"/>
    <dbReference type="KEGG" id="tba:TERMP_00609"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.611"/>
    <dbReference type="eggNOG" id="arCOG01360">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060488_0_0_2"/>
    <dbReference type="OMA" id="KRGPHNC"/>
    <dbReference type="OrthoDB" id="29724at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005909">
        <property type="entry name" value="RaSEA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004954">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01210">
        <property type="entry name" value="TIGR01210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="13"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="322" mass="37079" checksum="9E04622AF0430F9F" modified="2011-05-03" version="1">MSYWTSEDNVAGRKGVALFIILPTIGCYRYRIGQACYMCSYPASAPKMPWNQEEIVEYVKKALKKIEDKERVAVRIFTSGSFLDDGELKPETRKKIFKLLAGYDNIKEIVIESRSELVRYNAVKELADIAEDRHFEIAIGLETANNDIADVCINKGNTFEQFVNASEEIRSAGAKVKTYLLLKPIFLSERDGIEDVKESIKKAAPYTDTFSINITNIQKGTVYERLWEKREYRPPWLWSVVKILKWAKMTFPEKRILSDPVGAGSKRGPHNCGKCDKMIADAIRKFSTTQELKYLENLEHECIAEWEYIVQEGLLDWQLLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKE3</accession>
    <name>F0LKE3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466899.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00624"/>
    <dbReference type="EnsemblBacteria" id="ADT83601">
        <property type="protein sequence ID" value="ADT83601"/>
        <property type="gene ID" value="TERMP_00624"/>
    </dbReference>
    <dbReference type="GeneID" id="10040942"/>
    <dbReference type="KEGG" id="tba:TERMP_00624"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.626"/>
    <dbReference type="eggNOG" id="arCOG00388">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054697_2_0_2"/>
    <dbReference type="OMA" id="YGWDLAG"/>
    <dbReference type="OrthoDB" id="68178at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="417" mass="47234" checksum="E4AA3BCE6F211A9F" modified="2011-05-03" version="1">MMGRKILALLFGFLVLASAAPLSKAQSGTATSLNLVILVSDNEADHALAEKIAEYLNASVVVTPWGIYDPNVTSEIVARAPDLVLVIGGPNAVVDQYLSDLQDLGIPYVRRWGANRYETNLAVLQYLFENYSELMKNVKVVIVYGEDVTAIRRAENITGRTIIIYVDEDNFENQTQILNLLNTTAVVIINTPYSENITERVRERIREKLNANVTCENTTISAEDALLAIQIAENRTALAESLIANTSIPAAEKLLERAKDHLQEAKEAYNETKYGKAYGLAIAAKSLAEVVIKMGSEEMQVMMHKNETMKLKIQLEKLEDIIERLEELGFNVTEEKSLLEQVEQAYDNGNYELAKQLLAQLRDMIKTRYHSEKELIRVRWEEKEKHHREGREHKEENHHEEGHHEDHHNESGEENNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKG7</accession>
    <name>F0LKG7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="6">CDG synthase</shortName>
            <ecNumber evidence="6">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Archaeosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">queE</name>
        <name evidence="8" type="ordered locus">TERMP_00648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="6">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466923.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00648"/>
    <dbReference type="EnsemblBacteria" id="ADT83625">
        <property type="protein sequence ID" value="ADT83625"/>
        <property type="gene ID" value="TERMP_00648"/>
    </dbReference>
    <dbReference type="GeneID" id="10040966"/>
    <dbReference type="KEGG" id="tba:TERMP_00648"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.650"/>
    <dbReference type="eggNOG" id="arCOG02173">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066739_1_0_2"/>
    <dbReference type="OMA" id="IPQTHKM"/>
    <dbReference type="OrthoDB" id="64973at2157"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="44"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="255" mass="28731" checksum="3EAE11E1B0AF3EA0" modified="2011-05-03" version="1">MSYRLILAEIFNSWQGEGGSVEGSAFGRRQIFVRFAGCDLRCVWCDSRQFIDASKVLQWRYEIEPFSGEFKYKPNPATLDEVVDVILSLDTGDVHSISYTGGEPTLQIKPLKALMEKSSELGFKNFLETHGGFPERIAEIAHLVDYASVDIKDESARATGAWRDLVMMEVESIKILRKAGAKVYAKLVVTKDTKLENIEWYASLLEGSAPLVIQPKEPIDLTQKQLMEFYKAAAKILGRENVGLSFQVHKYLNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKH4</accession>
    <name>F0LKH4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glyceraldehyde-3-phosphate: ferredoxin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_01833</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>W-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60537"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468104.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01833"/>
    <dbReference type="EnsemblBacteria" id="ADT84808">
        <property type="protein sequence ID" value="ADT84808"/>
        <property type="gene ID" value="TERMP_01833"/>
    </dbReference>
    <dbReference type="GeneID" id="10042149"/>
    <dbReference type="KEGG" id="tba:TERMP_01833"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1832"/>
    <dbReference type="eggNOG" id="arCOG05072">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_440510_0_0_2"/>
    <dbReference type="OMA" id="CRFHRGW"/>
    <dbReference type="OrthoDB" id="5023at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0826">Tungsten</keyword>
    <feature type="domain" description="AFOR_N" evidence="10">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT84808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="652" mass="74022" checksum="9905A3AB2C45FC15" modified="2011-05-03" version="1">MKFTTLKINLKTKEISMNEIQQEGIYGIIDYALYLHDEVYKTYELDPYDPKNITVFGKGPFAGSVLPGAHRLVFIFRSPLYGTLFPSTMGGAAYIFQRVGVDFVVLEGKRDKPTIILLQGDGENVSVELHEMELEKLLQIWRSYKGEEGVYALTEYLIENFKDKFDEEFRIACVGPASLNTNFGAIFSQTLKNGKRVEGSEDWAARGGPGSVLLRAHNVVAIIFGGKAKKEFPGENIGDIKVARPIVEGVHKKPMFQVIGEKTTKYRYNPKLKTGGTFGGNYPAEGDFVPILNWQMPYINKEERIKIHENIMKHYWEPFNKEAIETKNWTTCGEPCPVVCKKFRRGHHVEYEPYEANGPLSGSIYIYASDISVHAVDAMGFDAIEFGGLASWVLELVYRGLLKPEEVGLSGKPDFTKDDLILKPVEASEKNARLVAELAHKVAFAETEIAKILGLGKRKASAILDEKFKDRLKYGESFKDYAVFTPLGEDGEICPTMYWAIGNYIPLPIQGRYWTFYQFGVFLEPEELASKIVASALYEFWYDNVGWCRFHRGWMKPVLKALFLEAYGENVDMEEHAKKVIRKLINYAKKAGYEPVFWDSMRVVDLVAAGAEEFGNEKWAEKFKEDKVGTAKEYLKRVLDTYSEILGVDWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKH7</accession>
    <name>F0LKH7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Maltose/maltodextrin transport ATP-binding protein MalK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468107.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01836"/>
    <dbReference type="EnsemblBacteria" id="ADT84811">
        <property type="protein sequence ID" value="ADT84811"/>
        <property type="gene ID" value="TERMP_01836"/>
    </dbReference>
    <dbReference type="GeneID" id="26137361"/>
    <dbReference type="KEGG" id="tba:TERMP_01836"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1835"/>
    <dbReference type="eggNOG" id="arCOG00177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OMA" id="MADRMMI"/>
    <dbReference type="OrthoDB" id="88924at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="368" mass="41220" checksum="15999D26931E370C" modified="2011-05-03" version="1">MVEVRLEKITKKFGDFTAVNELTLTIKDGEFLVLLGPSGCGKTTTLRMISGLETPTSGKIWFGDRDVTYLPPKDRNISMVFQSYAVWPHMTVYDNIAFPLKIKKYPKEEIDKRVKWAAELLQIEELLDRYPAQLSGGQRQRVAVARAIVVEPDVLLMDEPLSNLDAKLRVMMRAEIKKLQEKLKVTTIYVTHDQVEAMTMGDRIAVMNKGQLLQVGPPVEVYSKPNSIFVATFIGAPEMNLMDVTVKETDKGIALEGEGFEILLPEDLGEFLKDYVNKTVVFGIRPEHMTVEGISEVLHVKRKAKIKGTVDFVEALGTDTIIHAKVGGKIIKIKIPGHVPIELGRPVDIIIDLDNIHVFDKSTEKAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKL5</accession>
    <name>F0LKL5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01874</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468145.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01874"/>
    <dbReference type="EnsemblBacteria" id="ADT84849">
        <property type="protein sequence ID" value="ADT84849"/>
        <property type="gene ID" value="TERMP_01874"/>
    </dbReference>
    <dbReference type="GeneID" id="26137392"/>
    <dbReference type="KEGG" id="tba:TERMP_01874"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1873"/>
    <dbReference type="eggNOG" id="arCOG00467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025112_3_1_2"/>
    <dbReference type="OMA" id="DMLGIIN"/>
    <dbReference type="OrthoDB" id="58376at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="63"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="5">
        <location>
            <begin position="318"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="421" mass="48500" checksum="0049032E556D84F6" modified="2011-05-03" version="1">MEKRRENEQTYLDSIFEKYLNAKKIFKNKEVLRHSYTPKELPHRREQIEALAHILVPVLRGETPSNVFVYGKTGTGKTVTVKFVTEELKRISRKYNVPVDVIYLNCEIVDTQYRVLANIVNHFKHESGFEVPLVGWPTDEVYAKLKQIIDAKERFVIIVLDEIDKLIKKSGDDVLYSLTRINSELKNAKVSIVGISNDLKFKDYLDPRVLSSLSEEEVVFPPYDANQLRDILMQRAQEAFYPDVLDEAVVPLCAALAAREHGDARRALDLLRVSGEIAEREGASKVTEKHVWKAQEKIEQDTMEEVIKTLPLHSKILLYAIVLLDENGELPANTGDVYAVYKELCDYMDIEPLTQRRVSDLINELDMLGIINAKVVSKGRYGRTKEIRLNVTPYKVKNIYRFDYSLQPLLTVSIARQRRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKM2</accession>
    <name>F0LKM2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-methylthioadenosine/S-adenosylhomocysteine deaminase</fullName>
            <shortName evidence="1">MTA/SAH deaminase</shortName>
            <ecNumber evidence="1">3.5.4.28</ecNumber>
            <ecNumber evidence="1">3.5.4.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mtaD</name>
        <name evidence="3" type="ordered locus">TERMP_01881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + H2O + S-adenosyl-L-homocysteine = NH4(+) + S-inosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:20716"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57985"/>
            <dbReference type="EC" id="3.5.4.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + H2O + S-methyl-5'-thioadenosine = NH4(+) + S-methyl-5'-thioinosine</text>
            <dbReference type="Rhea" id="RHEA:25025"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:48595"/>
            <dbReference type="EC" id="3.5.4.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.28" evidence="1"/>
    <dbReference type="EC" id="3.5.4.31" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468152.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01881"/>
    <dbReference type="EnsemblBacteria" id="ADT84856">
        <property type="protein sequence ID" value="ADT84856"/>
        <property type="gene ID" value="TERMP_01881"/>
    </dbReference>
    <dbReference type="GeneID" id="10042197"/>
    <dbReference type="KEGG" id="tba:TERMP_01881"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1880"/>
    <dbReference type="eggNOG" id="arCOG00695">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_1_2"/>
    <dbReference type="OMA" id="ALIGKVC"/>
    <dbReference type="OrthoDB" id="40873at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090614">
        <property type="term" value="F:5'-methylthioadenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050270">
        <property type="term" value="F:S-adenosylhomocysteine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01281">
        <property type="entry name" value="MTA_SAH_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023512">
        <property type="entry name" value="Deaminase_MtaD/DadD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="51"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="425" mass="46944" checksum="4F1FEDDFF64FF39E" modified="2011-05-03" version="1">MSILIKNGYVIYGENLDVMKADIYIEDNKITKIGKNLNISADYVIDAKGKVVSPGFINLHTHSPMGLFRGLADDLPLMDWLKHHIWPKEAKLTREYTKAGAYLGALEMIKTGTTAFLDMYFYMDAVAEVVLESGLRGYLSYGMIDLGEPDKTEKEIKVALETMKFIEKLSSERVQFVFGPHAPYTCSIALLKKVRELANEHKKLITIHVAETMTEIGQITSRYGKSPVVLLDDIGFLADDVIIAHGVWLDSKDIHILARHRVSIAHNPASNMKLASGVMPIERLLNAGVNVGLGTDGSASNNNLDMLEEMKIAALLHKVHNLDPTVADAKTVFKMATQNGAKALRLDAGVIKKGALADLVIIDFNQPHLRPINNVISHLVYSANGNDVETTIVDGKILMLDREVFTLDEEKTLEKAEEVVEKLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKP5</accession>
    <name>F0LKP5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468175.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01904"/>
    <dbReference type="EnsemblBacteria" id="ADT84879">
        <property type="protein sequence ID" value="ADT84879"/>
        <property type="gene ID" value="TERMP_01904"/>
    </dbReference>
    <dbReference type="GeneID" id="26137440"/>
    <dbReference type="KEGG" id="tba:TERMP_01904"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1903"/>
    <dbReference type="eggNOG" id="arCOG01724">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1607223_0_0_2"/>
    <dbReference type="OMA" id="MKIPKIY"/>
    <dbReference type="OrthoDB" id="81031at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019217">
        <property type="entry name" value="DUF2118"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09891">
        <property type="entry name" value="DUF2118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="165" mass="19305" checksum="85C46814C76DA37D" modified="2011-05-03" version="1">MERIPQLYVESSYEECFDKEGRAKVNCIIIQGNVEVRLKKGEKIPEFIDIERAKILKKEVYDRFHFYVDKYEHKMLCDAIVVLPDRRTEIRLYKGDELMILPVEGYVSTLIAGVGNRVRKSDAFAAVTTKKGEVHYLKPPKNGVVVFIDEFTNRPHYLYYLLPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKQ1</accession>
    <name>F0LKQ1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468181.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01910"/>
    <dbReference type="EnsemblBacteria" id="ADT84885">
        <property type="protein sequence ID" value="ADT84885"/>
        <property type="gene ID" value="TERMP_01910"/>
    </dbReference>
    <dbReference type="GeneID" id="10042226"/>
    <dbReference type="KEGG" id="tba:TERMP_01910"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1909"/>
    <dbReference type="eggNOG" id="arCOG00014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065902_2_1_2"/>
    <dbReference type="OMA" id="DMNTRDT"/>
    <dbReference type="OrthoDB" id="98664at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="4"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="276" mass="30791" checksum="49060C05CE0E648E" modified="2011-05-03" version="1">MELDLVVIGHVSIDHIKFPRREEILQPGGAAAAVATSAALSGAKVGLVTKVGRDFPEEWLKKLSEILDIRGVYILEGRTIHIYMIYHEDGTVDAPVDMGVAQRMGEIEIPREYMSAKVFHIAPIPPEEQLKLVKRLKGKRISLDFNPTYIEDYKAKTELLKNIVKNTEIIFPNEREARMITKTEDIKEAAKVLHEWGAKIIVITKGERGVLVYDGEKFAEFKALPINEIVDPTGAGDAFAGGFLAYYAKGKSLKECVAQGLFRAREVLKKKGSWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKR1</accession>
    <name>F0LKR1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466938.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00663"/>
    <dbReference type="EnsemblBacteria" id="ADT83640">
        <property type="protein sequence ID" value="ADT83640"/>
        <property type="gene ID" value="TERMP_00663"/>
    </dbReference>
    <dbReference type="GeneID" id="10040981"/>
    <dbReference type="KEGG" id="tba:TERMP_00663"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.665"/>
    <dbReference type="eggNOG" id="arCOG01773">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_14_0_2"/>
    <dbReference type="OMA" id="CIVPRES"/>
    <dbReference type="OrthoDB" id="45753at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="44"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="225" mass="25991" checksum="1CADB5A32AD6FD92" modified="2011-05-03" version="1">MAQYFDKIAYRYDAWYQTKVGQYVDRTEKRLIFSMIKTKRGRALDLGCGTGNYTLELYRRGFDVIGVDLSQEMLKIAKAKIPDVLFIRANAYNLPFKKEAFDLVLSVTMFEFIHEPEKVLNEIYRILKLGGEVVIGTMNGKSLWFLFKRVKSLFVETAYRYARFYTSKELESLLANAGFSDVESKSVIFFPSFFPFVGIAEKVDRKVNKKLKNLGAFIAVRGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKT1</accession>
    <name>F0LKT1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative nickel-responsive regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_00683</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Transcriptional regulator.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="8">Binds 1 nickel ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466958.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00683"/>
    <dbReference type="EnsemblBacteria" id="ADT83660">
        <property type="protein sequence ID" value="ADT83660"/>
        <property type="gene ID" value="TERMP_00683"/>
    </dbReference>
    <dbReference type="GeneID" id="10041001"/>
    <dbReference type="KEGG" id="tba:TERMP_00683"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.684"/>
    <dbReference type="eggNOG" id="arCOG01008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113319_1_2_2"/>
    <dbReference type="OMA" id="AHNCLET"/>
    <dbReference type="OrthoDB" id="90041at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010045">
        <property type="term" value="P:response to nickel cation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00476">
        <property type="entry name" value="NikR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022988">
        <property type="entry name" value="Ni_resp_reg_NikR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0533">Nickel</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHH_1" evidence="9">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="NikR_C" evidence="10">
        <location>
            <begin position="56"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="139" mass="15930" checksum="736DA2E92B6DD0DD" modified="2011-05-03" version="1">MKKIVRFGVSIPQDLLAKFDKIIDEKGYTNRSEAIRDLIRDFIVRHEWEVGDEEVAGTITIVYNHDEAEVVKELLDLQHDYIDEIVSSLHVHMDEHNCLEVVVVKGKATRIKKIAERLISLKGVKHGKLVMTTTGRELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKX3</accession>
    <name>F0LKX3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative carbamoyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00725"/>
    <dbReference type="EnsemblBacteria" id="ADT83702">
        <property type="protein sequence ID" value="ADT83702"/>
        <property type="gene ID" value="TERMP_00725"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00725"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.727"/>
    <dbReference type="eggNOG" id="arCOG01188">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014411_2_0_2"/>
    <dbReference type="OMA" id="RTEMDYL"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="85"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="364"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="532" mass="59604" checksum="D1D37102E5945825" modified="2011-05-03" version="1">MILGIHDGHDAGAVLIKDGEIYAVNEERLNRIKHYRGFPKLSVLKVLEMGNVTPDEVELIVIAGIFRKRSRLLELEKNLAKIFGRDFKRKVLYVEHHLAHAASAYLTSGWREALALSIDAAGDGSSSSIYICRDGEMIKIAQSTYLDSLGDFYASVTELLGFKPMRHEGKVMSLAAYGKPSYDLSAIIELNGLTFENHLKVVGIEATKKLAEFFGFPFEKAKEVSANLKKGQLSGKLEQKAIEIAASAQKHLEKIVDELGLKLTKHGVPLAYAGGVAQNVKANMVLRRHFPDLWVFPAMHDGGLAFGAAVYVKSQLERLDGRWKPFKLEHVYLGPSYPEDEIEEFLREEGVKYEEIRAVSGFVADSLIDGKIVAFFQGKMEFGPRALGNRSILADPRDESIKEKLNLALRRDVFQPFAPTILEERIGDYLVDPYPNKFMTMSYYATEEFIKTAPAVVHVDGTTRPQTLEEEDNHTYYNIIKHFEKQSGVGAVLNTSFNMHGEPIVCSPEDALRTFRNAKLDVLVLEKFAVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL12</accession>
    <name>F0LL12_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468215.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="SMR" id="F0LL12"/>
    <dbReference type="STRING" id="391623.TERMP_01944"/>
    <dbReference type="EnsemblBacteria" id="ADT84919">
        <property type="protein sequence ID" value="ADT84919"/>
        <property type="gene ID" value="TERMP_01944"/>
    </dbReference>
    <dbReference type="GeneID" id="10042260"/>
    <dbReference type="KEGG" id="tba:TERMP_01944"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1943"/>
    <dbReference type="eggNOG" id="arCOG03280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026700_0_0_2"/>
    <dbReference type="OMA" id="HFMSAGL"/>
    <dbReference type="OrthoDB" id="3280at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015179">
        <property type="entry name" value="A-amylase/a-glucTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015178">
        <property type="entry name" value="A-amylase/a-glucTrfase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09094">
        <property type="entry name" value="DUF1925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09095">
        <property type="entry name" value="DUF1926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="2">
        <location>
            <begin position="19"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1925" evidence="3">
        <location>
            <begin position="309"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1926" evidence="4">
        <location>
            <begin position="390"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="656" mass="76955" checksum="57A1447980F60943" modified="2011-05-03" version="1">MINFIFGIHNHQPLGNFGWVFEDAYNKSYRPFMEILEEFPSMKVAVHFSGPLLEWINENHPEYIELLRKLVKRGQLEIVVAGFYEPVLAAIPKEDRIEQIKLLKEFAKKLGYDAKGVWLTERVWQPELVKTLRESGIEYVIVDDYHFMSAGLSKEDLYWPYYTEDGGEVIVVFPIDEKLRYLIPFRPVERTIEYLESLADSDPSKVAVFHDDGEKFGVWPGTYEWVYKKGWLRRFFDAVTSNEKINLMLYSEYLSKFTPRGVVYLPIASYFEMSEWSLPASQAKLFVEFVEKLKRRGEFEKYRVFVRGGIWKNFFYKYPESNFMHKRMLYVSKLVRNIPEARRYILKAQCNDAYWHGVFGGVYLPHLRRAVWENIIRAQSYVSTGNRVFDVDFDGRDEIILENGRFIATIKPHYGGSIFELSSKRKAVNYNDVLARRWEHYHDVSGTTPGEESEEGVASIHELGKKIPGEIKRELAYDWHLRAILQDHFISTTETLDTYRLVKYHELGDFVNQPYEFELNGNRVKLWRNGGIYAEKKVPARVEKVIELTNDGFLAKYSVSLGEPYETLFGVELNLAVHSVMENPEEFEADRILVNDTYGIGKVEIILDRKVKVWKFPIKTLSQSESGWDFIQQGVSYTLLFPTEKELEFEIKFREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL45</accession>
    <name>F0LL45_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468248.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01978"/>
    <dbReference type="EnsemblBacteria" id="ADT84952">
        <property type="protein sequence ID" value="ADT84952"/>
        <property type="gene ID" value="TERMP_01978"/>
    </dbReference>
    <dbReference type="GeneID" id="25394643"/>
    <dbReference type="KEGG" id="tba:TERMP_01978"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1975"/>
    <dbReference type="eggNOG" id="arCOG03797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067022_1_0_2"/>
    <dbReference type="OrthoDB" id="90585at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008553">
        <property type="entry name" value="DUF835"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05763">
        <property type="entry name" value="DUF835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="DUF835" evidence="2">
        <location>
            <begin position="123"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="258" mass="29756" checksum="A555960881EAB9B6" modified="2011-05-03" version="1">MHEIAQGFWYAGHFLLVLAIFVTLYMFYLSTKETHKTERHLIMIALLAIFIDILSELSLSAGITTTALYFLSIAGEFVGALIVILVLFRIRRGKVEIEFKPLPPNNRAEISITPGLLLLKADETNSQLVCRFSKGRQSLIISRKNEDYWRALGCEAPVIWLSKVENVRNAINPRNLEYLAHITVQLMKGEGEKFVFIDGLEYLIIENSFDRVFRLLTTLKDHALLHNTMVMVEFEPETLSKKELALLLREFPIFRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL48</accession>
    <name>F0LL48_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468251.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01981"/>
    <dbReference type="EnsemblBacteria" id="ADT84955">
        <property type="protein sequence ID" value="ADT84955"/>
        <property type="gene ID" value="TERMP_01981"/>
    </dbReference>
    <dbReference type="GeneID" id="10042296"/>
    <dbReference type="KEGG" id="tba:TERMP_01981"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1978"/>
    <dbReference type="eggNOG" id="arCOG03839">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058982_0_0_2"/>
    <dbReference type="OMA" id="REMIKIQ"/>
    <dbReference type="OrthoDB" id="69374at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="312" mass="36866" checksum="2E64552989183E31" modified="2011-05-03" version="1">MNEREFVEFIIQKTGIKKGNLIRKDIILHSILRELYSNEYFSSNYLFKGGTCLIKCYLGYYRFSVDLDFTSRDPQTWIELSRRSRERELKAEAVKLAELIEGIASKRGLEFKADLRDRNYMEFGGGSRMITFKLYYSEGVMREMIKIQVNLVERLLFEPKNVSAKSLLSDIQVSGEEEAYFSEFLEDYSDVPVSAYDLREILTEKVRALLTRKKVKFRDVYDLYYLEKEAGLRIEDYVEEITQKLLFALKFERYSINFQRVIKSISFLEATATEEELFLLNVPFNAEDFKKFLERLHNYILVQFGQKSETIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL53</accession>
    <name>F0LL53_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468256.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01986"/>
    <dbReference type="EnsemblBacteria" id="ADT84960">
        <property type="protein sequence ID" value="ADT84960"/>
        <property type="gene ID" value="TERMP_01986"/>
    </dbReference>
    <dbReference type="GeneID" id="10042301"/>
    <dbReference type="KEGG" id="tba:TERMP_01986"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1983"/>
    <dbReference type="eggNOG" id="arCOG03229">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102155_0_0_2"/>
    <dbReference type="OMA" id="FVANHYK"/>
    <dbReference type="OrthoDB" id="73889at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18481">
        <property type="entry name" value="DUF5616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF434" evidence="1">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5616" evidence="2">
        <location>
            <begin position="65"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="221" mass="25677" checksum="6CB3CBD77B4FA83A" modified="2011-05-03" version="1">MPSPFLDAYLDLKYLLNRGYRKSTALNFVANHYKLKKMERYFLARCVFSDKELENRQRKRMPIEFIRGRILAVDGFNVLITLESALEGKAILCEDGFVRDLKYQRGYKLSEKTEEMLFVLLEFLSQFSPEKVVFLYDKPVSKSGEVAEITGKIMREVGLSGLAKVVPSPDFELKKFKTVATSDFAVIDSVEHAVDIPQEYALRRRIKIKTFREVLREFKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL68</accession>
    <name>F0LL68_THEBM</name>
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        <submittedName>
            <fullName evidence="4">TldE/PmbA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00742"/>
    <dbReference type="EnsemblBacteria" id="ADT83719">
        <property type="protein sequence ID" value="ADT83719"/>
        <property type="gene ID" value="TERMP_00742"/>
    </dbReference>
    <dbReference type="GeneID" id="10041060"/>
    <dbReference type="KEGG" id="tba:TERMP_00742"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.744"/>
    <dbReference type="eggNOG" id="arCOG00322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_4_2_2"/>
    <dbReference type="OMA" id="DTMVAGN"/>
    <dbReference type="OrthoDB" id="49762at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="1">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="3">
        <location>
            <begin position="108"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="218"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="441" mass="48921" checksum="6DE03A4FCEE06834" modified="2011-05-03" version="1">MEELIRFGERFFDELEIAVYRNRDVGVNIELNEVSTSSVRQRTITVIRGIKDKRIGISIVDSKDKEEIKKAIEEAYKMAKLNAPDEKWVSLPEPGKYREPKKISKEVKEVSPDYFVDLATKAIKLALEKDKDFVVAGGGGGAEWSESLIVNSHGIDVFQEGGGAYFYLELIGRKNGNVTPGIFEFDAKLGLNLEVEKVVEDVAQKVKWAYNVEKSKTEEAKVIVGPWAVASLLSYALFPAFSGERAVKETTPLLNKVEQKIASELLTIYDDPFHELSLKPVIADDEGVPTRKNMLIENGVFKGFVWNNYWAKVYGTESTGNGTRNLSTGGIGIGFHSIVIEKGKENLSDLIAEIDHGYLIDGFQGAHSSNPDNGNFAVVANPAFLIENGEIKGSTVFMMSGNVYELINQIYEISKEQKVIPFHGTAITPWIAFENVRIAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL86</accession>
    <name>F0LL86_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467035.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00760"/>
    <dbReference type="EnsemblBacteria" id="ADT83737">
        <property type="protein sequence ID" value="ADT83737"/>
        <property type="gene ID" value="TERMP_00760"/>
    </dbReference>
    <dbReference type="GeneID" id="10041078"/>
    <dbReference type="KEGG" id="tba:TERMP_00760"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.762"/>
    <dbReference type="eggNOG" id="arCOG00578">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142653_1_0_2"/>
    <dbReference type="OMA" id="CGSPLFE"/>
    <dbReference type="OrthoDB" id="99528at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06677">
        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="106" mass="12324" checksum="BD5F02955EF13A2C" modified="2011-05-03" version="1">MALSDEEIRKIITPLLLSGAKMLDKHCPKCGSPLFELNGRVFCPVCEHRKKQRKAELKGIEEILMEKLKVLANNLPDDIEKLEKHLRVMEKIIEILERYKKLEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL92</accession>
    <name>F0LL92_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467041.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83743">
        <property type="protein sequence ID" value="ADT83743"/>
        <property type="gene ID" value="TERMP_00766"/>
    </dbReference>
    <dbReference type="GeneID" id="26136218"/>
    <dbReference type="KEGG" id="tba:TERMP_00766"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.768"/>
    <dbReference type="eggNOG" id="arCOG07084">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2613813_0_0_2"/>
    <dbReference type="OMA" id="HDELGIK"/>
    <dbReference type="OrthoDB" id="117060at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="77" mass="8936" checksum="A267E207F6FF54EF" modified="2011-05-03" version="1">MDVFELARRYHQELGIKEPSFATLAAEIFGELGLKIYEHLKGEGYTLKSTRFIDYDKSLVLEVVKEEKAFEILLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLA4</accession>
    <name>F0LLA4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467053.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00778"/>
    <dbReference type="EnsemblBacteria" id="ADT83755">
        <property type="protein sequence ID" value="ADT83755"/>
        <property type="gene ID" value="TERMP_00778"/>
    </dbReference>
    <dbReference type="GeneID" id="26136233"/>
    <dbReference type="KEGG" id="tba:TERMP_00778"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.780"/>
    <dbReference type="eggNOG" id="arCOG08354">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2766267_0_0_2"/>
    <dbReference type="OMA" id="FAFYQMN"/>
    <dbReference type="OrthoDB" id="127274at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="66" mass="7544" checksum="B88C34EAE1468080" modified="2011-05-03" version="1">MPAYGGTPSGWISIILGLILIVIVVFAFYQMNKTLSELKLELSNLRNVLEETKRYTEDVKKKLEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLB5</accession>
    <name>F0LLB5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467064.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00789"/>
    <dbReference type="EnsemblBacteria" id="ADT83766">
        <property type="protein sequence ID" value="ADT83766"/>
        <property type="gene ID" value="TERMP_00789"/>
    </dbReference>
    <dbReference type="GeneID" id="10041107"/>
    <dbReference type="KEGG" id="tba:TERMP_00789"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.791"/>
    <dbReference type="eggNOG" id="arCOG00538">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_4_3_2"/>
    <dbReference type="OMA" id="IRLMGAF"/>
    <dbReference type="OrthoDB" id="124053at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="76" mass="8400" checksum="3E25A737C3E3659C" modified="2011-05-03" version="1">MIRIKLMGALAHLAGSREIYIEVDKPKTVDEILKEIVKGYDRLHDKIIMVNGKVARGDVIVKDGDEIKVMPVLSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLC8</accession>
    <name>F0LLC8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467077.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00802"/>
    <dbReference type="EnsemblBacteria" id="ADT83779">
        <property type="protein sequence ID" value="ADT83779"/>
        <property type="gene ID" value="TERMP_00802"/>
    </dbReference>
    <dbReference type="GeneID" id="10041120"/>
    <dbReference type="KEGG" id="tba:TERMP_00802"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.804"/>
    <dbReference type="eggNOG" id="arCOG03808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096716_0_0_2"/>
    <dbReference type="OMA" id="HEVENRI"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="249" mass="27996" checksum="2A80582A86828FCF" modified="2011-05-03" version="1">MRVVSTGIPELDLALGGGLIKGGLIVISYESDLNGSAGWILGLKILKNRIDEGDLGILINHRYPLSNLFNRLSVVGLNAEATLKEGRLKILDVFGSLYGIKYSYEGVHQFGSFDPRMYIPKMVELFEKILTPEQIENSIAAIFTAGSFAMRIGEERYMKVIEESMAFNEKLKLEKGIAFPTRIYFLNRDEISPRFSAWLSSIADQVISITSHEVENRIGGKLRITKSLLPNFELKSFRYWVAKGNIEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLD8</accession>
    <name>F0LLD8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468263.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01993"/>
    <dbReference type="EnsemblBacteria" id="ADT84967">
        <property type="protein sequence ID" value="ADT84967"/>
        <property type="gene ID" value="TERMP_01993"/>
    </dbReference>
    <dbReference type="GeneID" id="26137575"/>
    <dbReference type="KEGG" id="tba:TERMP_01993"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1990"/>
    <dbReference type="eggNOG" id="arCOG03828">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093378_2_0_2"/>
    <dbReference type="OMA" id="RHRKSVY"/>
    <dbReference type="OrthoDB" id="97382at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="148" mass="17166" checksum="406709F46D7176F0" modified="2011-05-03" version="1">MTTSAMILGNDRRMFVIEYLQKCNGKADLRDLVEYIAKKEGNTDRRHRKSVYVSLVQTHIPKMEREGIIEFKHGTIKLIQVPENVDVYMEIVNKNDVRWATVYSMLALGSAAMSYYVQSWEGFVISTVFLSMSVIQRLKEKRIIKRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLI1</accession>
    <name>F0LLI1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468306.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02036"/>
    <dbReference type="EnsemblBacteria" id="ADT85010">
        <property type="protein sequence ID" value="ADT85010"/>
        <property type="gene ID" value="TERMP_02036"/>
    </dbReference>
    <dbReference type="GeneID" id="10042351"/>
    <dbReference type="KEGG" id="tba:TERMP_02036"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2033"/>
    <dbReference type="eggNOG" id="arCOG03169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061108_0_0_2"/>
    <dbReference type="OMA" id="PITNARL"/>
    <dbReference type="OrthoDB" id="56889at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="365" mass="42594" checksum="C9F4046CEEEFC4A3" modified="2011-05-03" version="1">MLFDPKPKVKREDIFDREEELKKVMDSIKNYPITLILGIRRVGKSSVLRVALNESDAIGIYIDARKLYMNVSGWITKDELKRELESALLNLKPKILKSLQSYFNLAKFSIKGFELSFREKSLADILENLNEFGEDRNKLIVLAFDEAQYLRFYGTKGGREFLALVAHAYDNLPNIHFVLTGSEIGLLHDFLGFENYEALLFGRIYNEITIEPFTREKSIEFLKKGFDEANLKVSEWELKKAVDVLDGIPGWLVEYGFHYLHSNDPQKALEYTMKKARQSILEELKELERRSKRYTLILKAVALGFNRWEKIKEYLETHSGRITNARFSSLLKNLERMSWIKSELKDGKKVYSMTDPVIERVLREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLM5</accession>
    <name>F0LLM5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467100.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00825"/>
    <dbReference type="EnsemblBacteria" id="ADT83802">
        <property type="protein sequence ID" value="ADT83802"/>
        <property type="gene ID" value="TERMP_00825"/>
    </dbReference>
    <dbReference type="GeneID" id="10041143"/>
    <dbReference type="KEGG" id="tba:TERMP_00825"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.827"/>
    <dbReference type="eggNOG" id="arCOG03847">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1656978_0_0_2"/>
    <dbReference type="OMA" id="RPYMMIP"/>
    <dbReference type="OrthoDB" id="78275at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="156" mass="17833" checksum="791BA15A46007A0A" modified="2011-05-03" version="1">MKAYITMLGRSTWAMINAYYAVVMEKKYRPNEIYIFLEDIYQDKIPVAVEALKIISAAFGFSPKVEVITIEEANFKEARRKVESLLRKLKDKGFEIAIDITSGRKALVAGALVHGVPLKVDHVFYLALAEKDLQFANRPYMMIPIHSQKLEDFMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLQ4</accession>
    <name>F0LLQ4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase chain D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00854</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467129.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00854"/>
    <dbReference type="EnsemblBacteria" id="ADT83831">
        <property type="protein sequence ID" value="ADT83831"/>
        <property type="gene ID" value="TERMP_00854"/>
    </dbReference>
    <dbReference type="GeneID" id="10041172"/>
    <dbReference type="KEGG" id="tba:TERMP_00854"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.857"/>
    <dbReference type="eggNOG" id="arCOG01548">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_2"/>
    <dbReference type="OMA" id="GGRMHYM"/>
    <dbReference type="OrthoDB" id="4328at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="5">
        <location>
            <begin position="139"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="391" mass="44613" checksum="D9739D48D78A5A34" modified="2011-05-03" version="1">MVSQSELIKEARENGMDLLPLDKDTYELFFGPQHMATENFSIILKMDGHRVVKAIANPGFLHRGFEKLAELRPWYTNIALLLRICVPEPDVPEMIYSMAVEEIMGWEVPERAQWIRTVVLEMARVSAYLFWTMGMAFKLGVYTAGQWAAAYRERFMALFEELTGARVYHIYTIPGGVRRDIPGDKWLRQLKDTVEYVKSKLPDFDHLIFENYITFRRMEGIGVMDKKFALEEGVTGPNLRATGVPYDVRRADPYLLYPELDFEVPVLKEGDALSRALIRRYELEQDLYILEQLLEMGPPSGPYKIQDPRLKNLPRFKVPAGDAFAHVESTKGDFGAYVVSDGGNKPYRVQIRGPSIAHGIRVLEQLLVGARIADVPVILVSLDNCPPDIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLT1</accession>
    <name>F0LLT1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467156.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00881"/>
    <dbReference type="EnsemblBacteria" id="ADT83858">
        <property type="protein sequence ID" value="ADT83858"/>
        <property type="gene ID" value="TERMP_00881"/>
    </dbReference>
    <dbReference type="GeneID" id="10041199"/>
    <dbReference type="KEGG" id="tba:TERMP_00881"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.884"/>
    <dbReference type="eggNOG" id="arCOG00683">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040997_0_0_2"/>
    <dbReference type="OMA" id="SFCHIPH"/>
    <dbReference type="OrthoDB" id="13813at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="174"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="319"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="434" mass="50228" checksum="1B7B6A43A4DAB801" modified="2011-05-03" version="1">MKRSVTVKLQPSKAQEKILFELAQATAIIWNKINYQRLKQFKEFGKIDFSTTEKEAYHKFKNWIGGSTVQQLARKNAEAWRSFFSLNRKKKKGELPEWFKPRPPKFVREENGRKLFIIPLRNDQYRINGNVLELRRLGKFGRLRIQFKGRIHLRGKQGRLEIIYDDVKRKFYAHISYTVEEKLTKKGWVKVPRQPPGSLIAGIDLGVNNLMAVYVENCESLLVNGRPLKSIAFYWQKKIAEYQSKINKSGCKKSRKLRRMHEKAKLQAKHYINTAVRQTVEKLYHLGVSRIVVGYPREIARNSDKGRKQNFILSHVWRFNYVIKRLKEVAEEYGVTVIITDEAFTSQTCPLCGQCHSNARFVRGLFKCHREGVVMNADLVGAFNILKKVVRTITLSLEGLKAFKVRGNGLKAEPEGLIFGFNEAPQTSPPMARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLT2</accession>
    <name>F0LLT2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00882"/>
    <dbReference type="EnsemblBacteria" id="ADT83859">
        <property type="protein sequence ID" value="ADT83859"/>
        <property type="gene ID" value="TERMP_00882"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00882"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.885"/>
    <dbReference type="eggNOG" id="arCOG04026">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1718316_0_0_2"/>
    <dbReference type="OMA" id="CELYVMA"/>
    <dbReference type="OrthoDB" id="92233at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="154" mass="17675" checksum="859D0219453B84ED" modified="2011-05-03" version="1">MKKGQSSLEYLIFIAVAIIIVALVIKYTEPAVKEVPITGIVYIDPETSPVVEQTSEKIKWKVTYYYPPGCQATKCDFYVSVNLKYYYSSDKYRIDVYIGGEADRIKKIKVSMCTGWEKVVDANGFDRNYFVGYFAKKELDPLFPCQVTVMAWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLT6</accession>
    <name>F0LLT6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467161.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00886"/>
    <dbReference type="EnsemblBacteria" id="ADT83863">
        <property type="protein sequence ID" value="ADT83863"/>
        <property type="gene ID" value="TERMP_00886"/>
    </dbReference>
    <dbReference type="GeneID" id="10041204"/>
    <dbReference type="KEGG" id="tba:TERMP_00886"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.889"/>
    <dbReference type="eggNOG" id="arCOG01403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_2_2"/>
    <dbReference type="OMA" id="CWRDTGH"/>
    <dbReference type="OrthoDB" id="83551at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="189"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="366" mass="42594" checksum="9B9352480CD7F8F0" modified="2011-05-03" version="1">MRILILNWREINDPLAGGAEKYLYEIGKRIAKMGHSVVFFGREYYPQIPKKDKINEIKIVRGGNKFTVYLWALWYLAKNRKKFDVVIDSENGIPFFSPLVFNNVICVMHHVHLDVFDKELSFPLNLVGKFLEGRLMPYIYKNKLFVSVSPSTKKEIIERLKIKPEQIKIVYNGVDYEKLSTQSIISKFKDPTVIYFGRVKRYKRIDHVIRALALTKRKIKNVKLIIAGKMDNNICNELKKLADELNVYVEWYSNVENSLKNELLSKSWIYVITSLKEGWGISVIEANACGTPVVSYDVPGLRDSVRNSYNGILVRNGNIKALSKVIICLLENPKVRKKLSHNARKWAKRFSWERSMQYIIQIISER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLZ8</accession>
    <name>F0LLZ8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dolichol-p-glucose synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468393.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02123"/>
    <dbReference type="EnsemblBacteria" id="ADT85097">
        <property type="protein sequence ID" value="ADT85097"/>
        <property type="gene ID" value="TERMP_02123"/>
    </dbReference>
    <dbReference type="GeneID" id="10042438"/>
    <dbReference type="KEGG" id="tba:TERMP_02123"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2120"/>
    <dbReference type="eggNOG" id="arCOG00894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_4_0_2"/>
    <dbReference type="OMA" id="FASEMVI"/>
    <dbReference type="OrthoDB" id="96698at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="371" mass="41447" checksum="6765668142F9C09F" modified="2011-05-03" version="1">MSIEVSIVLPTMNEEDAVKAVLPKIKDVMEKTGISYEIIVVDKSNDRTPEIAKNLGATVIRQKGKGYGDAYLEGFKHARGKYIIMLDPDGSYDPLDIPRLLGPLLEGKADFVMGTRLKGKIEKGAMPRLHRYIGNPLLTKILNILFKAGISDAHCGMRAIRKDALEKLPLKCKGMEFASEMVIEAAKKKLRIAEVPITYHPRIGESKLSSFRDGWRHLRLMLLYSPSHLFLFPGIILALLGIGLLSYTYLVNPIRLHTMILGSLLTIVGFQIINFGISSKVYAVREGLEEPSRLTKFFMRYSILEEGLIVGGIMFLIGISLGIKIFLEWKASGYGSLFKINEGILVLTLTVLGLQLMFFSFFVSIYMLKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM19</accession>
    <name>F0LM19_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467164.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83866">
        <property type="protein sequence ID" value="ADT83866"/>
        <property type="gene ID" value="TERMP_00889"/>
    </dbReference>
    <dbReference type="GeneID" id="10041207"/>
    <dbReference type="KEGG" id="tba:TERMP_00889"/>
    <dbReference type="eggNOG" id="arCOG04026">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_205638_2_0_2"/>
    <dbReference type="OMA" id="MMRKAQG"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007166">
        <property type="entry name" value="Class3_signal_pept_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04021">
        <property type="entry name" value="Class_IIIsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="61" mass="6117" checksum="DDDC2ACCD30F291D" modified="2011-05-03" version="1">MRRKAQGAIEYLFMIAAALIIIAIVLRYLKGTGSSTGSAVSSAASALTSQVASELSAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM50</accession>
    <name>F0LM50_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-splicing endonuclease</fullName>
            <ecNumber evidence="1">4.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA-intron endonuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">endA</name>
        <name evidence="4" type="ordered locus">TERMP_00921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467195.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00921"/>
    <dbReference type="EnsemblBacteria" id="ADT83897">
        <property type="protein sequence ID" value="ADT83897"/>
        <property type="gene ID" value="TERMP_00921"/>
    </dbReference>
    <dbReference type="GeneID" id="10041238"/>
    <dbReference type="KEGG" id="tba:TERMP_00921"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.922"/>
    <dbReference type="eggNOG" id="arCOG01701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114393_0_0_2"/>
    <dbReference type="OMA" id="KGPGIDH"/>
    <dbReference type="OrthoDB" id="98477at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01833">
        <property type="entry name" value="EndA_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006678">
        <property type="entry name" value="tRNA_intron_Endonuc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036740">
        <property type="entry name" value="tRNA_intron_Endonuc_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016442">
        <property type="entry name" value="tRNA_splic_arch_short"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="PTHR21227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02778">
        <property type="entry name" value="tRNA_int_endo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005285">
        <property type="entry name" value="tRNA_splic_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="SSF53032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55267">
        <property type="entry name" value="SSF55267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_int_endo_N" evidence="3">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_int_endo" evidence="2">
        <location>
            <begin position="80"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="171" mass="20372" checksum="92E20D66236FED6A" modified="2011-05-03" version="1">MKEPIAFYLSGERVFSEREKAINQFYNKRYFGEVVNGKLFLSLIEAAYLMDRGKIKVFDGNKELSLKELFDLGRKKDEQFDLKFLVYKDLRDRGYVVKTALKYGSHFRVYRKGMEEHSDWLVWVVSENQKMFPNDLTARVRVAHGVRKKMIMAVVDEDNDIVYYQIERVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM87</accession>
    <name>F0LM87_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467232.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00958"/>
    <dbReference type="EnsemblBacteria" id="ADT83934">
        <property type="protein sequence ID" value="ADT83934"/>
        <property type="gene ID" value="TERMP_00958"/>
    </dbReference>
    <dbReference type="GeneID" id="10041275"/>
    <dbReference type="KEGG" id="tba:TERMP_00958"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.961"/>
    <dbReference type="eggNOG" id="arCOG05764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_1_2_2"/>
    <dbReference type="OMA" id="ILMNRLC"/>
    <dbReference type="OrthoDB" id="101593at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="121" mass="14271" checksum="C3810E9C74BF1EE4" modified="2011-05-03" version="1">MEPHEFKLNEEGLRAVLPPLEAEIMEYMWKVKIATAGEVYEHMKERHPEMRRSTVSILMNRLCERGLLKRSVETGRGGMRYVYSITTTREEFEKRIVETILNALMNNFKEATFAYLSKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM97</accession>
    <name>F0LM97_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, Fe-S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468416.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02146"/>
    <dbReference type="EnsemblBacteria" id="ADT85120">
        <property type="protein sequence ID" value="ADT85120"/>
        <property type="gene ID" value="TERMP_02146"/>
    </dbReference>
    <dbReference type="GeneID" id="26137742"/>
    <dbReference type="KEGG" id="tba:TERMP_02146"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2143"/>
    <dbReference type="eggNOG" id="arCOG01502">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_3_2_2"/>
    <dbReference type="OMA" id="ILCRLCM"/>
    <dbReference type="OrthoDB" id="105930at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12800">
        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="177" mass="19396" checksum="90D382A2B6936B11" modified="2011-05-03" version="1">MSEEAKSEERIWILITPDKCSGCRLCEVACSLEHEGIIWPEASRIRIYELLPGVNVPHTCVQCPDYPCVNACNFGALTVDENTGAVLVNEEKCTECGACVLACPGKVPRIPAGKGSVVICDLCGGNPKCVEVCHEAGHDALTLVRGNYRSIYRTFAKEPVEKSMDLARKMYGEEFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMA6</accession>
    <name>F0LMA6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02155"/>
    <dbReference type="EnsemblBacteria" id="ADT85129">
        <property type="protein sequence ID" value="ADT85129"/>
        <property type="gene ID" value="TERMP_02155"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02155"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2151"/>
    <dbReference type="eggNOG" id="arCOG03166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142661_0_0_2"/>
    <dbReference type="OMA" id="NTAYLIE"/>
    <dbReference type="OrthoDB" id="21452at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF234" evidence="1">
        <location>
            <begin position="35"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="164" mass="19453" checksum="7084670299653AAA" modified="2011-05-03" version="1">MENLLRLGLVRREKPLFGGRKVSLYQISDPMLLTWFTLVYPQVDRISLGIATLENAYKVFSIRFEELAREFLILKKPFEFSQIGRWWWKGEEIDIIAVDENTAYLIEVKWKDLSEKDGRRILSLLKEKAKNVRFNGEFRYGIIAKSIEEKERFELAFSLEDIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMD2</accession>
    <name>F0LMD2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative activity regulator of membrane protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_02181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468451.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02181"/>
    <dbReference type="EnsemblBacteria" id="ADT85155">
        <property type="protein sequence ID" value="ADT85155"/>
        <property type="gene ID" value="TERMP_02181"/>
    </dbReference>
    <dbReference type="GeneID" id="26137817"/>
    <dbReference type="KEGG" id="tba:TERMP_02181"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2176"/>
    <dbReference type="eggNOG" id="arCOG01912">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1850705_0_0_2"/>
    <dbReference type="OMA" id="DMMVTAF"/>
    <dbReference type="OrthoDB" id="106825at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="48"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT85155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="137" mass="15187" checksum="7E579F0782E9A8C4" modified="2011-05-03" version="1">MDYFPILLLILGLLIIVLDMMVAAFITPIGIAFAVLGLLLGLGVNFNVAFVISLISAVISYQLFARLIKKETVDIGKPKYTFELKGKRGKVKRIKGDEVWVELEGEEWLAKPLDDVKEGDEVVVVDVDGVKLIVRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMG8</accession>
    <name>F0LMG8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_00971</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467245.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00971"/>
    <dbReference type="EnsemblBacteria" id="ADT83947">
        <property type="protein sequence ID" value="ADT83947"/>
        <property type="gene ID" value="TERMP_00971"/>
    </dbReference>
    <dbReference type="GeneID" id="10041288"/>
    <dbReference type="KEGG" id="tba:TERMP_00971"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.974"/>
    <dbReference type="eggNOG" id="arCOG01029">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_2_1_2"/>
    <dbReference type="OMA" id="NTHQDYK"/>
    <dbReference type="OrthoDB" id="65810at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="10">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="8">
        <location>
            <begin position="92"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="9">
        <location>
            <begin position="250"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="351" mass="39771" checksum="D1C9D81C24CBB4F6" modified="2011-05-03" version="1">MYKVISPGRVNLIGEHTDYTFGYVMPMAVNLYTVIEGEKSESVELYSEHFKETRTFELNNLEKENSWIDYVKGIYKVLFEAGFKLRGIRGRISGNLPIGAGLSSSASFELAIMQFLNEVYNLEISREDMALLAQKAENEFVGIPCGIMDQFIIALGKKGHAVFIDTETLHYEYIPLPKDMQILVFYTGIRRKLAASAYADRRRVAETILKRIGKKSSKEVTERDLRGLPGIYKKRFAYIIRENERVLEAKEALKEGDIEQFGRILTKAHWDIAENYGVSCGELDFFVRKVVKLGAYGARLTGAGFGGAAIAVVDREESKKIGEKILREYTKAFNWKAQYFLVEASDGVKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LML9</accession>
    <name>F0LML9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467296.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01022"/>
    <dbReference type="EnsemblBacteria" id="ADT83998">
        <property type="protein sequence ID" value="ADT83998"/>
        <property type="gene ID" value="TERMP_01022"/>
    </dbReference>
    <dbReference type="GeneID" id="10041339"/>
    <dbReference type="KEGG" id="tba:TERMP_01022"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1025"/>
    <dbReference type="eggNOG" id="arCOG05763">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1922875_0_0_2"/>
    <dbReference type="OMA" id="LEIINWM"/>
    <dbReference type="OrthoDB" id="119628at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018662">
        <property type="entry name" value="DUF2095"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09868">
        <property type="entry name" value="DUF2095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="132" mass="15953" checksum="FE09E055AFB153C7" modified="2011-05-03" version="1">MDKKKKKPVDEFAWQEYDKEEFREKFPALAEELEEREGIVIEGYRVDEFQVLEEEELEEEKIDFSGYNPTVIDFLRRCETDEEALEIINWLEERGEITHEMAKDLRITLVKKGVRAFGPKKEWGWYERHGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMM4</accession>
    <name>F0LMM4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stomatin/prohibitin-family membrane protease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467301.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01027"/>
    <dbReference type="EnsemblBacteria" id="ADT84003">
        <property type="protein sequence ID" value="ADT84003"/>
        <property type="gene ID" value="TERMP_01027"/>
    </dbReference>
    <dbReference type="GeneID" id="26136477"/>
    <dbReference type="KEGG" id="tba:TERMP_01027"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1030"/>
    <dbReference type="eggNOG" id="arCOG01915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_3_3_2"/>
    <dbReference type="OMA" id="NAVLYFR"/>
    <dbReference type="OrthoDB" id="49614at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="25"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="274" mass="30802" checksum="E1F76C78BBA9845F" modified="2011-05-03" version="1">MVSFIGGNFIVTAIVLLFVLVFLGSALKIVKEYERAVIFRLGRVVGARGPGLFFIIPIFEKAVIVDLRTQVLDVPVQETITKDNVPVRVNAVVYFRVVDPIKAVTQVKNFIMATSQIAQTTLRSVIGQAHLDELLSEREKLNRELQRIIDEATDPWGIKVTTVEIKDVELPTGMQRAMARQAEAERERRARITLAEAERQAAEKLREAAEIISEHPMALQLRTLQTISDVASDKSNVIVLTLPMEMLKLFRSLADTSEVVRKKLEKEAEEQEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMP1</accession>
    <name>F0LMP1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycerol-1-phosphate dehydrogenase [NAD(P)+]</fullName>
            <shortName evidence="11">G1P dehydrogenase</shortName>
            <shortName evidence="11">G1PDH</shortName>
            <ecNumber evidence="11">1.1.1.261</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Enantiomeric glycerophosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">sn-glycerol-1-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">egsA</name>
        <name evidence="15" type="ordered locus">TERMP_01044</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:21412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>NADP(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycerol-1-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.261" evidence="11"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467318.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01044"/>
    <dbReference type="EnsemblBacteria" id="ADT84020">
        <property type="protein sequence ID" value="ADT84020"/>
        <property type="gene ID" value="TERMP_01044"/>
    </dbReference>
    <dbReference type="GeneID" id="10041361"/>
    <dbReference type="KEGG" id="tba:TERMP_01044"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1047"/>
    <dbReference type="eggNOG" id="arCOG00982">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038362_0_0_2"/>
    <dbReference type="OMA" id="ALHGEQC"/>
    <dbReference type="OrthoDB" id="57545at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106357">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106358">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase [NADP+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00497_A">
        <property type="entry name" value="G1P_dehydrogenase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023002">
        <property type="entry name" value="G1P_dehydrogenase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="115"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADT84020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="346" mass="37562" checksum="099F14017BF5CD06" modified="2011-05-03" version="1">MHLMELPREVLLGENLKDKVGEVAKRLKLGERVLILYGPKTKEIAGREVRHHLKESFDVHSLTIKKASMKEVGKTVEKIKNENVQWIVAVGGGSIIDVAKLASFKSDISFISFPTTASHDGIASANASIKDLNAKTSIKAKPPIAVIADVKVIKTAPYRYLAAGVGDMISNLTAVKDWQLAHKLKGEYYSEYAASLSLMSAKMVIKNADIIRLGNEESVRKVIKGLISSGVAMSIAGSSRPASGAEHLFSHALDLIAPKPALHGEQCGVGTIIMAYLHGLKWQKIRETLKKVNAPTNAYELGIDPEYIIEALTIAHTIRPERYTILGKDGLTREAAEKAAKITGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMR6</accession>
    <name>F0LMR6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467343.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01069"/>
    <dbReference type="EnsemblBacteria" id="ADT84045">
        <property type="protein sequence ID" value="ADT84045"/>
        <property type="gene ID" value="TERMP_01069"/>
    </dbReference>
    <dbReference type="GeneID" id="26136519"/>
    <dbReference type="KEGG" id="tba:TERMP_01069"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1072"/>
    <dbReference type="eggNOG" id="ENOG502N58S">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2271134_0_0_2"/>
    <dbReference type="OrthoDB" id="139447at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="103" mass="12285" checksum="2B34931242D6B1D0" modified="2011-05-03" version="1">MVSRSDYAFKYSMRELKRLFPNTPFLEVKMQELEGDEVRVKSLEEFIDVCDKLRLLVEYSVDDENGSVRFLTKYQGRTLVYEIDINEFYKAVSRIRELKESVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMS2</accession>
    <name>F0LMS2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="7" type="ordered locus">TERMP_01075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467349.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01075"/>
    <dbReference type="EnsemblBacteria" id="ADT84051">
        <property type="protein sequence ID" value="ADT84051"/>
        <property type="gene ID" value="TERMP_01075"/>
    </dbReference>
    <dbReference type="GeneID" id="10041392"/>
    <dbReference type="KEGG" id="tba:TERMP_01075"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1078"/>
    <dbReference type="eggNOG" id="arCOG04137">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_2"/>
    <dbReference type="OMA" id="NKYGCRE"/>
    <dbReference type="OrthoDB" id="17629at2157"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="6">
        <location>
            <begin position="188"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="217"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="421" mass="46894" checksum="8B35EE521B4A02B0" modified="2011-05-03" version="1">MDCTKDYCVKDINLAPEGEKKIDWVSRFMPVLQSIRKDFEKEKPFKGIRIAACLHLEMKTAFLLLTLKAGGAEVSATASNPLSTQDDVVAALARAGVKVYAWKGENTEAYYENMHKALDIKPNILIDDGADMISVVHRERQELIDDIWGASEETTTGVIRLRAMEKDGVLKFPIIAVNDSYTKYLFDNRYGTGQSTWDGIIRTTNLLVAGKNVVVVGYGWCGRGIAIRARGLGATVIVVEVDPIRALEARMDGFLVMPMSKAAEIGDIFITATGDINCIRKEHFEVMKDGVILANAGHFDVEISKPDLEALAVGISKPRPNITEYKLKDGRRLYLLAEGRLVNLAAADGHPAEIMDMSFALQAMAAKYIKDNHEKLENKVYVLPREIDEMVARIKLKAMGIEIEQLTEEQKKYLESWEHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMY2</accession>
    <name>F0LMY2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol-1-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467409.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01135"/>
    <dbReference type="EnsemblBacteria" id="ADT84111">
        <property type="protein sequence ID" value="ADT84111"/>
        <property type="gene ID" value="TERMP_01135"/>
    </dbReference>
    <dbReference type="GeneID" id="10041452"/>
    <dbReference type="KEGG" id="tba:TERMP_01135"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1138"/>
    <dbReference type="eggNOG" id="arCOG04213">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050011_0_0_2"/>
    <dbReference type="OMA" id="YEVNAFY"/>
    <dbReference type="OrthoDB" id="46491at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="213"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="383" mass="42706" checksum="82F5684CE1962A73" modified="2011-05-03" version="1">MARVVILGQGYVGSIFAIGVERIKRGDLGYYGIPLANELPIKVEDIEIVGSYDVDKSKIGRPLYEVVKRYWEDEIPESLKNVVVRKGIHLGSLRNLPIEAEGLEDRMTLKEAVEKIVEEWKELKPDVIVNVCTTEAFKPFNSKEELIKAIENDNRERLTATQVYAYAASLYAKEVGGAAFVNAIPTLIANDNAFLELAKESNLVIFGDDGATGATPLTADVLAHLAQRNRYVKDIAQFNIGGNTDFLALTDKDRNKSKEYTKSSVVKDILGYDAPHYIKPTGFLEPLGDKKFIAMHIEYVSFNGAIDELVITGRINDSPALAGLLVDLVRLGKIAVERKEWGTVYEVNAFYMKNPGPAEKGNIPRIIAYEKMRQWAGLKPRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMZ2</accession>
    <name>F0LMZ2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multiple resistance and pH regulation protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467419.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01145"/>
    <dbReference type="EnsemblBacteria" id="ADT84121">
        <property type="protein sequence ID" value="ADT84121"/>
        <property type="gene ID" value="TERMP_01145"/>
    </dbReference>
    <dbReference type="GeneID" id="10041462"/>
    <dbReference type="KEGG" id="tba:TERMP_01145"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1148"/>
    <dbReference type="eggNOG" id="arCOG03121">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125825_5_0_2"/>
    <dbReference type="OMA" id="WIYALDI"/>
    <dbReference type="OrthoDB" id="128222at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="94" mass="10489" checksum="9935A328E7F2F891" modified="2011-05-03" version="1">MSLESQFFLLMKFVIPLYLLAFVIYAIRAFKGPTIVDIILAVDCMSFDIAAFMAILAVYFKSAFLISAAITLALWAYLLDIYIAKHLVSKEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN15</accession>
    <name>F0LN15_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467442.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01168"/>
    <dbReference type="EnsemblBacteria" id="ADT84144">
        <property type="protein sequence ID" value="ADT84144"/>
        <property type="gene ID" value="TERMP_01168"/>
    </dbReference>
    <dbReference type="GeneID" id="26136630"/>
    <dbReference type="KEGG" id="tba:TERMP_01168"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1171"/>
    <dbReference type="eggNOG" id="arCOG05747">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167326_0_0_2"/>
    <dbReference type="OMA" id="ENIERYM"/>
    <dbReference type="OrthoDB" id="125653at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="99" mass="11060" checksum="63DEDA194DCE07A6" modified="2011-05-03" version="1">MKLAVYLLFLQAFFLLYYYVSENSLIYLAFGLLNFILAWAILRGEKRAVKVTLVYKGVDLFFSILMLMSGVLSAGISALIDFAIIHDLIGLFGAGNKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN20</accession>
    <name>F0LN20_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Archaeal succinyl-CoA ligase (ADP-forming), beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467447.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01173"/>
    <dbReference type="EnsemblBacteria" id="ADT84149">
        <property type="protein sequence ID" value="ADT84149"/>
        <property type="gene ID" value="TERMP_01173"/>
    </dbReference>
    <dbReference type="GeneID" id="26136636"/>
    <dbReference type="KEGG" id="tba:TERMP_01173"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1176"/>
    <dbReference type="eggNOG" id="arCOG01338">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063044_1_1_2"/>
    <dbReference type="OMA" id="FGHAIMF"/>
    <dbReference type="OrthoDB" id="65977at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="235" mass="26423" checksum="B742998DAE42FCA6" modified="2011-05-03" version="1">MKDEALKVIEDVLSRGRKALVEYEAKQVLKAYELPVPDEKLAKTLDEALEYAKEIGYPVVLKLMSPQILHKSDAKIIALNIKNEEELKKKWEEIHENAKKYRPDAEILGVLVAPMLKPGREVIIGVTEDPQFGHAIMFGLGGIFVEILKDVTFRIIPIEEKDAWAMIKSIKGYPILAGARGEPPADMKALVDMMLKVSKLVDDLKDYIKEMDLNPVFVYNEGEGAVVVDARIILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN64</accession>
    <name>F0LN64_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747425.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT85203">
        <property type="protein sequence ID" value="ADT85203"/>
        <property type="gene ID" value="TERMP_02230"/>
    </dbReference>
    <dbReference type="GeneID" id="10549054"/>
    <dbReference type="KEGG" id="tba:TERMP_02230"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2224"/>
    <dbReference type="HOGENOM" id="CLU_1369592_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="199" mass="23693" checksum="02D56A60030A7197" modified="2011-05-03" version="1">MPSWRVHKKWGERILGFSTSKIDQLIDQDETHDAGRYDINIFERQVTHVKSLYGETGVEYYILHHLLDYAEQRLLSILSDEAIREYYERTRSAEEVLREVRRKLLEDLQEFKLKDDPFIAKTIKKIVKFYQNLDMLDELIFDIMNGDNFPKRLGNIIYMKAIPHSKSWYFIDQKKVDEIVNIAIECIGEIFGILAKKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN67</accession>
    <name>F0LN67_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2357 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
            <plasmid evidence="2 3">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02233"/>
    <dbReference type="EnsemblBacteria" id="ADT85206">
        <property type="protein sequence ID" value="ADT85206"/>
        <property type="gene ID" value="TERMP_02233"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02233"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2227"/>
    <dbReference type="eggNOG" id="arCOG06467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027714_0_0_2"/>
    <dbReference type="OMA" id="DIYKMHT"/>
    <dbReference type="OrthoDB" id="28603at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018633">
        <property type="entry name" value="DUF2357"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007505">
        <property type="entry name" value="PDDEXK_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09823">
        <property type="entry name" value="DUF2357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04411">
        <property type="entry name" value="PDDEXK_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2357" evidence="1">
        <location>
            <begin position="77"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="554" mass="64974" checksum="8F7159A40E7B705D" modified="2011-05-03" version="1">MEKSRNKNFLPEISLDKGGKYQLKAKKKKESIIKDAETLYLFEWQEYMIIGEKEFSVRIGDEKIEAEKINENTYIATFQFKNYIGKTHIEILEGTKPISLEFKNFEVLSEKVGKIYNVSPENTEELIQKHEELYNALLKYISEKSISLPFSVSAPTAFGVEESEEPMSELFVYHFLVNNRERIISAYEEIIRRPHRKLVEREEWLNFWEVSEVDEDTVMSIITHPEYLIKAEPSSIAVAEYLNNHVPTKVAQRIKYESFDTHENRFAKHFLNELITWGEKAIAAILTSSYLTKEQKENATSKLTSILGELEYYATSDIFDDVGEMVIFPYTSQVLLKREGYRDLLQLWREFRSYSPFFDEMQKAIDNKDIAKLYEYWCFFKLVEELGKILGQENLRIIVEPTGELSERGHVYAEFDNGWRLYYNLKKRGYSVSLRPDFLLLKGRNIIGVFDAKFKLDVVDVNEFAEEDREMERAPNFQTWAKLEDIYKMHTYRDALNAKFAVVLYPGDRSLFFDKISKKCIGDLKECKGKFDLRALLDRDNVKLEGIGYLSCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN98</accession>
    <name>F0LN98_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747459.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT85237">
        <property type="protein sequence ID" value="ADT85237"/>
        <property type="gene ID" value="TERMP_02264"/>
    </dbReference>
    <dbReference type="GeneID" id="10549088"/>
    <dbReference type="KEGG" id="tba:TERMP_02264"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2258"/>
    <dbReference type="HOGENOM" id="CLU_1745635_0_0_2"/>
    <dbReference type="OrthoDB" id="104523at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="149" mass="16949" checksum="5360151FB13C56D7" modified="2011-05-03" version="1">MFESILKKLHRTNAPITGKSKIPAAGVKAFEAILKSKGLKEGSEAVKIALSEFSKYNNENEETFQEFKKILEREFSGLRGARIIKAKAKALKELWEAEAKALFGPVRRTKWISIRVTEEEYNKILEEANKEGLDVSNYIRKKLGLSYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGY5</accession>
    <name>F0LGY5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoserine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01217"/>
    <dbReference type="EnsemblBacteria" id="ADT84193">
        <property type="protein sequence ID" value="ADT84193"/>
        <property type="gene ID" value="TERMP_01217"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01217"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1219"/>
    <dbReference type="eggNOG" id="arCOG01158">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036368_4_5_2"/>
    <dbReference type="OMA" id="AINPHEG"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006386">
        <property type="entry name" value="HAD-SF_hydro_IB_PSP-like_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01491">
        <property type="entry name" value="HAD-SF-IB-PSPlk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="212" mass="24325" checksum="A8671C66DBA3AA1E" modified="2011-05-03" version="1">MEIRLIAFDLEGTLVKSKSSWVELHKRFGTWDKGREYAERFFRGEFDYQTWADLDASLWKGRKREEILEWANSVEYMDGVKELFEFLRENNFKIAIISGGLMCLAKRVADELNADYVFANELIFDEEGRVTGKVIARVDFQNKGEILAKLKEDLKPSLTIAVGDGHNDIAMFKVADVSIAVNPHEGVEGDYVANDLKEVIEIIRKILEERGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH65</accession>
    <name>F0LH65_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent thymidylate synthase</fullName>
            <shortName evidence="1">FDTS</shortName>
            <ecNumber evidence="1">2.1.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FAD-dependent thymidylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thymidylate synthase ThyX</fullName>
            <shortName evidence="1">TS</shortName>
            <shortName evidence="1">TSase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thyX</name>
        <name evidence="2" type="ordered locus">TERMP_00049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:29043"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.148"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate synthase ThyX family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.148" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466325.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00049"/>
    <dbReference type="EnsemblBacteria" id="ADT83027">
        <property type="protein sequence ID" value="ADT83027"/>
        <property type="gene ID" value="TERMP_00049"/>
    </dbReference>
    <dbReference type="GeneID" id="10040368"/>
    <dbReference type="KEGG" id="tba:TERMP_00049"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.50"/>
    <dbReference type="eggNOG" id="arCOG01883">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077585_0_0_2"/>
    <dbReference type="OMA" id="AKLGPRC"/>
    <dbReference type="OrthoDB" id="77034at2157"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01408">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Involved in ionization of N3 of dUMP, leading to its activation" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="79"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="90"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="244" mass="29071" checksum="6304F495E4A0163B" modified="2011-05-03" version="1">MDRIKVRLINYTPKPLETVTWAALISYWEEWESEAFERTTMADVRRHLPKVLSYGHESILEHAVFTFAIEGCSRVCTHQLIRHRIASYTQQSHRYIKLNPQDVEETFLIPESIKEKPELYEKWKQLMEGAIRLYKEAYENGVHQEDARYILPQAVRTKIVVTMNLRELKHFFGLRTCERAQWEINYVAWKMLEEISKVEELNPIIKWAKLGPRCIQLGYCPERELMPEGCLKRTREKWMEIAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH88</accession>
    <name>F0LH88_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466348.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00072"/>
    <dbReference type="EnsemblBacteria" id="ADT83050">
        <property type="protein sequence ID" value="ADT83050"/>
        <property type="gene ID" value="TERMP_00072"/>
    </dbReference>
    <dbReference type="GeneID" id="10040391"/>
    <dbReference type="KEGG" id="tba:TERMP_00072"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.72"/>
    <dbReference type="eggNOG" id="arCOG05813">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178227_0_0_2"/>
    <dbReference type="OMA" id="VEFAIPG"/>
    <dbReference type="OrthoDB" id="119876at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="106" mass="12138" checksum="DD63F35FABA7FC0E" modified="2011-05-03" version="1">MGIFRRIFKKPKREVNKIEIVSRKPVGRFRVLQVFNIFGKQVLAGEVIDGIIYPGYKLKGRDVGIVRNIEKNRKKVDFAVSGDVVALMLENKMDVNDGELLEVYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH90</accession>
    <name>F0LH90_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">RNA 3'-terminal phosphate cyclase</fullName>
            <shortName evidence="5">RNA cyclase</shortName>
            <shortName evidence="5">RNA-3'-phosphate cyclase</shortName>
            <ecNumber evidence="5">6.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rtcA</name>
        <name evidence="8" type="ordered locus">TERMP_00074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.5.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.4" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466350.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00074"/>
    <dbReference type="EnsemblBacteria" id="ADT83052">
        <property type="protein sequence ID" value="ADT83052"/>
        <property type="gene ID" value="TERMP_00074"/>
    </dbReference>
    <dbReference type="GeneID" id="10040393"/>
    <dbReference type="KEGG" id="tba:TERMP_00074"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.74"/>
    <dbReference type="eggNOG" id="arCOG04125">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027882_0_0_2"/>
    <dbReference type="OMA" id="PKPGLSH"/>
    <dbReference type="OrthoDB" id="52581at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00200">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017770">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="PTHR11096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="PTHR11096:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52913">
        <property type="entry name" value="SSF52913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03399">
        <property type="entry name" value="RNA_3prim_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RTC" evidence="6">
        <location>
            <begin position="8"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="RTC_insert" evidence="7">
        <location>
            <begin position="184"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="5">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="290"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="350" mass="38416" checksum="F26A59339DE97A78" modified="2011-05-03" version="1">MKVIDGSYGEGGGQILRTAVALSAITGEPIKIINIRANRPNPGLRPQHLHGILALKELCNAKVKGAEVGSKVLEFYPGKIQSKHIKVPIKTAGSITLVLQALLPAMAFADREVTFEITGGTDVPWSPPIDYLKNVTLFALEKIGLRAEIEIRRRGHYPKGGGSVMGKVEPWEEKRELRATRFTKIESFEGISHAVKLPSHVAVRQAKAAKQVIERAYPNIPINIIEEYYERDKDPHLGPGSGIVVWANTDVLRLGGDALGKRGKPAEMVGEEAAIELLNQLKPRHAVDKFLGDQLIPFLAFAGGEIWVSEITKHLVTNVWVVEQFFGKVFKVEGEVGKPGRVRVVKSVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHC5</accession>
    <name>F0LHC5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L32e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl32e</name>
        <name evidence="6" type="ordered locus">TERMP_00109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466385.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00109"/>
    <dbReference type="EnsemblBacteria" id="ADT83087">
        <property type="protein sequence ID" value="ADT83087"/>
        <property type="gene ID" value="TERMP_00109"/>
    </dbReference>
    <dbReference type="GeneID" id="26135425"/>
    <dbReference type="KEGG" id="tba:TERMP_00109"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.110"/>
    <dbReference type="eggNOG" id="arCOG00781">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071479_3_1_2"/>
    <dbReference type="OMA" id="HPSGYEE"/>
    <dbReference type="OrthoDB" id="110802at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00810">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_L32e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023654">
        <property type="entry name" value="Ribosomal_L32e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_L32e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_L32e_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="PTHR23413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="SSF52042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="126" mass="14840" checksum="5532B5A39107337C" modified="2011-05-03" version="1">MNEKARLLRIRAKLKRKKPKFLRQEWWRFPKFKNDPKWRRPKGIDSKMRLKKKGKPRSPSIGWSSPKLVRGLHPSGYEEVLVHNVKELEALDPARQAARIARTVGKKKRIMIVERARELGIKVLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHD5</accession>
    <name>F0LHD5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467560.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01287"/>
    <dbReference type="EnsemblBacteria" id="ADT84262">
        <property type="protein sequence ID" value="ADT84262"/>
        <property type="gene ID" value="TERMP_01287"/>
    </dbReference>
    <dbReference type="GeneID" id="26136770"/>
    <dbReference type="KEGG" id="tba:TERMP_01287"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1289"/>
    <dbReference type="eggNOG" id="arCOG05095">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2191163_0_0_2"/>
    <dbReference type="OMA" id="REYMGRF"/>
    <dbReference type="OrthoDB" id="117290at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="112" mass="13234" checksum="0665D3047DF0309D" modified="2011-05-03" version="1">MSKEKGKIPQLFSGSIDELTRPKTKKADKRREELKKIKKQKTLYISQDTNLKLIELYAEESRRQSNIVEDAVNLYYYLKKAMGEKNFDELMSAVLREDPEFLRSYLEKAKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHP4</accession>
    <name>F0LHP4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="7">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">leuS</name>
        <name evidence="11" type="ordered locus">TERMP_00151</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466426.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00151"/>
    <dbReference type="EnsemblBacteria" id="ADT83128">
        <property type="protein sequence ID" value="ADT83128"/>
        <property type="gene ID" value="TERMP_00151"/>
    </dbReference>
    <dbReference type="GeneID" id="10040469"/>
    <dbReference type="KEGG" id="tba:TERMP_00151"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.152"/>
    <dbReference type="eggNOG" id="arCOG00809">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004174_0_0_2"/>
    <dbReference type="OMA" id="AWNMAFQ"/>
    <dbReference type="OrthoDB" id="4914at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_A">
        <property type="entry name" value="Leu_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020791">
        <property type="entry name" value="Leu-tRNA-lgase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="PTHR45794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="10"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="717"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="642"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="645"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="958" mass="111757" checksum="C8B3F802B6E9287E" modified="2011-05-03" version="1">MVDFRAIEEKWQKKWNEEKIFEPKIDRNKPKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRMQGYNVLFPMAWHITGSPIVGIAERIKHRDPQTIFVYRDVYKVPEEILWTFEDPINIVKYFMKAAKETFIRAGFSVDWSREFHTTSLHPQFNAFITWQFLRLKEKGLIVKGAHRVRWDPVVGTPLGDHDLMDGEDVPILEYILIKFILEENGEIIYLPAATLRPETVYGVTNMWLNPNATYVKAKVKYKGKEETWIVSKEAAYKLSFQDKEIEVLEEFKGEKLIGKWVKNPVTGDEVIILPADFVDPDNATGVVMSVPAHAPFDHAALEDLKRNTEILLKYDIDPRIVENITYISLIELEGYGEFPAVEEAEKLGVKSQEDKEKLEQATKTIYKAEYHKGIFKIEPYKGIPVSKVKDLVAEDMKKKGIADIMYEFADKNVISRFGNRAVVKIIHDQWFIDYGNPEWKAKAFECLEQMKIIPESRRAQFRAVFDWIEKKACARKIGLGTPLPWDPEWVIESLSDSTIYMAYYTISRAINKYGIKGEQLIPELFDYIFLEERSGEKEKELSNKTGIPAEVIKEMKEEFEYWYPLDWRCSAKDLIPNHLTFFVFNHVAIFDKKYWPKGIAVNGYGTLEGKKMSKSKGNVLNFIDAINENGADVVRLYIMSLAEHDSDFDWRSKEVSKLKGQLERFYELISEFAEYDAKPAELKDIDKWMLHRINKAIEGATKALEEFRTRTAVQWAFYSILNDLRWYMRRTEGRDDEAKRYVLRTLADVWVRLMAPFTPHICEELWEKLGGDGFVSLAKWPEPNPEWWNETIELEENYIKSLIEDIKEIIRVAKLEDAKRAYIYTAPEWKWKVAEIVAEKRDFKAVMSEVMKDPEMRKKGKEVASLVNKLIKERAFEIKRIDEEKALKEAKDFIEKELGLEIIINPEEDKGGKAKQAMPMKPAVFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHV0</accession>
    <name>F0LHV0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467648.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84350">
        <property type="protein sequence ID" value="ADT84350"/>
        <property type="gene ID" value="TERMP_01375"/>
    </dbReference>
    <dbReference type="GeneID" id="10041691"/>
    <dbReference type="KEGG" id="tba:TERMP_01375"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1375"/>
    <dbReference type="eggNOG" id="arCOG00288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059362_3_1_2"/>
    <dbReference type="OMA" id="GHMGQNI"/>
    <dbReference type="OrthoDB" id="107170at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020051">
        <property type="entry name" value="SagB-type_dehydrogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03605">
        <property type="entry name" value="antibiot_sagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="196" mass="21989" checksum="FB1AAFE7FC9D633D" modified="2011-05-03" version="1">MKIKLPAPKREGRMSLEEAIDRRKSIRRYKDESLTIEEVSQVLWAAYGINRWGKRTSPSAGACYPFEVYVVVENVEGLSPGIYRYDGEAHRLELIREGHFRKSLAEACLGQRCVATAPVNIVIVAHYERTTGRYGERGVRYVHIDAGHMGQNIYLQATALNLGTVAVGAFRDEEVKKVLEVPGEPLYIFPLGIPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHX5</accession>
    <name>F0LHX5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467673.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01400"/>
    <dbReference type="EnsemblBacteria" id="ADT84375">
        <property type="protein sequence ID" value="ADT84375"/>
        <property type="gene ID" value="TERMP_01400"/>
    </dbReference>
    <dbReference type="GeneID" id="25394639"/>
    <dbReference type="KEGG" id="tba:TERMP_01400"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1400"/>
    <dbReference type="eggNOG" id="arCOG03580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065200_4_0_2"/>
    <dbReference type="OMA" id="YMYVRLA"/>
    <dbReference type="OrthoDB" id="92990at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="191" mass="21899" checksum="57EED1653FBA45C2" modified="2011-05-03" version="1">MSWLYVVLFALWLVLDGYVFSEIKKIYEKGEILPTNVAIAVWTSYILHFVLIVWASLEGLWRLPINTTVALASGLVVAAVGSIIMLLGIWEFRSFKRMSGLDTSKLVTTGIYRYSRNPQNLGLLLIFLGISLAGRSLLALLLTAAFAIGFHKYVVELEEPYLERIFGEEYRRYKERTPRYFGRPKSRRDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI06</accession>
    <name>F0LI06_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine-phosphate pyrophosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01431"/>
    <dbReference type="EnsemblBacteria" id="ADT84406">
        <property type="protein sequence ID" value="ADT84406"/>
        <property type="gene ID" value="TERMP_01431"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01431"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1431"/>
    <dbReference type="eggNOG" id="arCOG04214">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096980_1_2_2"/>
    <dbReference type="OMA" id="VSAMHIT"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="135" mass="15347" checksum="4261198725D6D092" modified="2011-05-03" version="1">MVRKELYLSTRGEIDLIDITHEVERFVEESGITNGQVLIFVPGATGAVVTIEHENGLLEDFKRILKELVPRGQGYKHDLIDNNAHSHLRASLLGPSLVLPIIDGELMRGIWQQIFFVELDVRPRRRRIVLQAIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI14</accession>
    <name>F0LI14_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein transport protein Sec61 gamma subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secE</name>
        <name evidence="10" type="ordered locus">TERMP_00191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00191"/>
    <dbReference type="EnsemblBacteria" id="ADT83168">
        <property type="protein sequence ID" value="ADT83168"/>
        <property type="gene ID" value="TERMP_00191"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00191"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.192"/>
    <dbReference type="eggNOG" id="arCOG02204">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191921_0_1_2"/>
    <dbReference type="OMA" id="DFLHQCR"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="SSF103456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="63" mass="6935" checksum="9B424E142AED0EF3" modified="2011-05-03" version="1">MPTRGYMEKLKNFLSESKRVLLVTKKPSGKEYKMAAKITGLGIILIGLIGMIIRIIGTLITGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI20</accession>
    <name>F0LI20_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466472.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00197"/>
    <dbReference type="EnsemblBacteria" id="ADT83174">
        <property type="protein sequence ID" value="ADT83174"/>
        <property type="gene ID" value="TERMP_00197"/>
    </dbReference>
    <dbReference type="GeneID" id="10040515"/>
    <dbReference type="KEGG" id="tba:TERMP_00197"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.198"/>
    <dbReference type="eggNOG" id="ENOG502N56K">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1096752_0_0_2"/>
    <dbReference type="OrthoDB" id="126397at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="253" mass="28370" checksum="3645F550E6EA71BE" modified="2011-05-03" version="1">MNEVLPPDIQKGEGKSVDEYLSEGFNLIISNPKILFPFVIPLIVNVLYGVYLLEHFFRGLHFTSIQLFKVSIPNWGHFLMISILAVIIIVVFMLWGIESIAYFVIKEQNISKAISFGVKRLPVAFVNYIIVLLIISALFVPVVVVHSLWLIIPYSFLIAILVSPLIFLLSPVIIEKTFGIVDTFVLYKRTFKRSLILGLLYSLVSSAVSSLIPIVGGALNVLLVIPGFVATYSLLYRDYREKGNKESGFISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI83</accession>
    <name>F0LI83_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467711.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01438"/>
    <dbReference type="EnsemblBacteria" id="ADT84413">
        <property type="protein sequence ID" value="ADT84413"/>
        <property type="gene ID" value="TERMP_01438"/>
    </dbReference>
    <dbReference type="GeneID" id="10041754"/>
    <dbReference type="KEGG" id="tba:TERMP_01438"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1438"/>
    <dbReference type="eggNOG" id="arCOG03794">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094093_0_0_2"/>
    <dbReference type="OMA" id="PWGMNID"/>
    <dbReference type="OrthoDB" id="72767at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="194" mass="21312" checksum="A4EDBD4238BD9AC2" modified="2011-05-03" version="1">MKSREIALIGIMLALSLMLNVSPLKVPTQWGMTIDLVAIPIVVVYLLLGFASSLVSLALLFIGLSIVSPASWLGASMKFFATLSVILGLETAKKLTKFSPDSYTEKQLIAFIVSAYLISIAIRIPLMVGLNYYYALPIWLGIPREQVIPKIEEWFHIPFWLVIAIPNAVQSAVDIIGGILISLPVIRALPHILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI87</accession>
    <name>F0LI87_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01442"/>
    <dbReference type="EnsemblBacteria" id="ADT84417">
        <property type="protein sequence ID" value="ADT84417"/>
        <property type="gene ID" value="TERMP_01442"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01442"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1442"/>
    <dbReference type="eggNOG" id="arCOG01045">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02433">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_730799_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="377" mass="43310" checksum="3619E0F083BACB77" modified="2011-05-03" version="1">MIIGVVGKIAAGKTTIAKFLEENGFCRISCSDPLIDLLTHNVDAYSQIPELPQKAEPTRDKLIEYGRYLKETYGEDILIRLALDKMRHCKDVVIDGVRSRGEIGAIKRRGGAIIYVEAKPELRYERLVRRKAEKDKAINSFDDFKRMDDEEERLYHTSKLKDLADFVIANEGTLGDLRKEVKKILEFLNTLVVIAPCLLSPFTVYRGPKEKEYRAASALMRFFGKYHYLKILAYPCPEFILLGFPRLPASKEVYEKLGMREYAKKVAEFIVRSIGEEQPSRVILIGVKGSPTCGVFHTTSSDPEEYPYEKMEEFKKLSKKERFKLAAEIAKDFKVIEGEGTLFELLKRKIEGIYLEFDKDNLEGSLRRIEKALRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIC0</accession>
    <name>F0LIC0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase chain B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467748.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01475"/>
    <dbReference type="EnsemblBacteria" id="ADT84450">
        <property type="protein sequence ID" value="ADT84450"/>
        <property type="gene ID" value="TERMP_01475"/>
    </dbReference>
    <dbReference type="GeneID" id="26136963"/>
    <dbReference type="KEGG" id="tba:TERMP_01475"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1475"/>
    <dbReference type="eggNOG" id="arCOG01553">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_2"/>
    <dbReference type="OMA" id="WVFHASG"/>
    <dbReference type="OrthoDB" id="100307at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="21"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="148" mass="16272" checksum="2353CADB30F4E548" modified="2011-05-03" version="1">MGKLTNFKRSLWVFHASGGSCNACDIEIVALLTPRYDVERFGIKLAGSPRHADVLLVTGAIPRDFADKLRRIYEQMPDPKAVIVVGNCGTSGGVFYDSYNIAGPIDEIIPVDVYVPGCPPRPEAIIDAVVKAWLKLEKLEKELEGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LID5</accession>
    <name>F0LID5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane bound hydrogenase MbhI-like subunit</fullName>
        </submittedName>
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        <name evidence="2" type="ordered locus">TERMP_01490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467763.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01490"/>
    <dbReference type="EnsemblBacteria" id="ADT84465">
        <property type="protein sequence ID" value="ADT84465"/>
        <property type="gene ID" value="TERMP_01490"/>
    </dbReference>
    <dbReference type="GeneID" id="10041806"/>
    <dbReference type="KEGG" id="tba:TERMP_01490"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1490"/>
    <dbReference type="eggNOG" id="arCOG05308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2103645_0_0_2"/>
    <dbReference type="OMA" id="GYWDALY"/>
    <dbReference type="OrthoDB" id="120936at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="115" mass="13360" checksum="70A38AFF2A2B8383" modified="2011-05-03" version="1">MFGYWDALYFIYVFIIGLIISYILMKWGERASMGTRRVGAGTKVYLSGEDEDEVIPQFEHLRGYFTGRHVMWGLIRGINRMFITFRREHTGLLTDYVAYLLVTVAIILGVLIIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LID7</accession>
    <name>F0LID7_THEBM</name>
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        <submittedName>
            <fullName evidence="6">Membrane bound hydrogenase MbhG-like subunit</fullName>
        </submittedName>
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        <name evidence="6" type="ordered locus">TERMP_01492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ADT84467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
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    <dbReference type="EnsemblBacteria" id="ADT84467">
        <property type="protein sequence ID" value="ADT84467"/>
        <property type="gene ID" value="TERMP_01492"/>
    </dbReference>
    <dbReference type="GeneID" id="10041808"/>
    <dbReference type="KEGG" id="tba:TERMP_01492"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1492"/>
    <dbReference type="eggNOG" id="arCOG03072">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_082058_2_1_2"/>
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    <dbReference type="OrthoDB" id="108209at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="120" mass="13335" checksum="385CA65D6DFE6285" modified="2011-05-03" version="1">MIPFQFITAFLLIFMGIYAFLYKRNLIKLILALNIIDSGIHLLLISLGYRLENGVLPTAPIYTGYETLRGTPMVGPIPQALVLTSIVIGVCVLALAMALTINAYRHYGSLDINKLRRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIE4</accession>
    <name>F0LIE4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">TERMP_01499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01499"/>
    <dbReference type="EnsemblBacteria" id="ADT84474">
        <property type="protein sequence ID" value="ADT84474"/>
        <property type="gene ID" value="TERMP_01499"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01499"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1499"/>
    <dbReference type="HOGENOM" id="CLU_2629904_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="77" mass="9397" checksum="CC93DD36B2BDD4C3" modified="2011-05-03" version="1">MHFTPSIVLRGVDYVKSIHWKFWNYLKASINKFVYIRPLIFTNFLLRIFCLKRAVLYLHCEFGTFQNSFKSNKRNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIP3</accession>
    <name>F0LIP3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467793.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01520"/>
    <dbReference type="EnsemblBacteria" id="ADT84495">
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    </dbReference>
    <dbReference type="GeneID" id="10041836"/>
    <dbReference type="KEGG" id="tba:TERMP_01520"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1520"/>
    <dbReference type="eggNOG" id="arCOG03793">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1340770_0_0_2"/>
    <dbReference type="OMA" id="EYPSTFP"/>
    <dbReference type="OrthoDB" id="82554at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005489">
        <property type="entry name" value="DUF257"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03192">
        <property type="entry name" value="DUF257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="211" mass="24408" checksum="A6B71C16E12785CB" modified="2011-05-03" version="1">MEIHSIGKFLKGHVRGGDVVLIEYPSAYPFEDLAWGEIIPEISHDNQIVVDDFFGIGDLSFRNYIRKISPKDYRRIIEITKHIKVIKIGPGRASYGSIVDEIPLTYEISEFMKNYYDAIRKALVDSIKPLYFLSFGLSEYFYFGKERAIQAILFSRSNLPVEDWTSIYLINKNLVEMPQLAILEDISAWIIDINQEEEYTVKIKKGNGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIP7</accession>
    <name>F0LIP7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01524"/>
    <dbReference type="EnsemblBacteria" id="ADT84499">
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        <property type="gene ID" value="TERMP_01524"/>
    </dbReference>
    <dbReference type="GeneID" id="10041840"/>
    <dbReference type="KEGG" id="tba:TERMP_01524"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1524"/>
    <dbReference type="eggNOG" id="arCOG05772">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2140308_0_0_2"/>
    <dbReference type="OMA" id="GHFFLEQ"/>
    <dbReference type="OrthoDB" id="104308at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="114" mass="13860" checksum="52CEF0C497AA877B" modified="2011-05-03" version="1">MRTLKEWDVKVKLVRTKRGAILHKIELSENHFFLEQNPLKDSKYGVAYRKIKNKFPEFYMFWEIKNNRYTGRLLVGSFLEKEEIDEFITLLAQSEEFKKFEHILEEIEEEEKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIQ0</accession>
    <name>F0LIQ0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467800.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01527"/>
    <dbReference type="EnsemblBacteria" id="ADT84502">
        <property type="protein sequence ID" value="ADT84502"/>
        <property type="gene ID" value="TERMP_01527"/>
    </dbReference>
    <dbReference type="GeneID" id="26137038"/>
    <dbReference type="KEGG" id="tba:TERMP_01527"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1527"/>
    <dbReference type="eggNOG" id="arCOG02317">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119372_0_0_2"/>
    <dbReference type="OMA" id="PLMGWEV"/>
    <dbReference type="OrthoDB" id="71317at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014424">
        <property type="entry name" value="UCP004897_ACT"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004897">
        <property type="entry name" value="UCP004897_ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="197" mass="22820" checksum="47D38F4504213BED" modified="2011-05-03" version="1">MMLILEAYFKNYPARRKVAEFLFENGLSVKKGKIYLRDVEVPISELSRVIGVNRKIIYHTIEYIEKTYPLKLIFERLTPLPSLIDVAPIMGWEVLEIEFDKELYSKAISSVLQILSENGVSIMEIFSRNLRQEESKAYIVIDGTLPVEVFVKIKDIPGFKKLILHTPEKRKEKFVCAYCEVRYCPKKVALENISAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIT9</accession>
    <name>F0LIT9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA:Cm32/Um32 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467839.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01566"/>
    <dbReference type="EnsemblBacteria" id="ADT84541">
        <property type="protein sequence ID" value="ADT84541"/>
        <property type="gene ID" value="TERMP_01566"/>
    </dbReference>
    <dbReference type="GeneID" id="10041882"/>
    <dbReference type="KEGG" id="tba:TERMP_01566"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1566"/>
    <dbReference type="eggNOG" id="arCOG01018">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056931_3_0_2"/>
    <dbReference type="OMA" id="PIMNLSH"/>
    <dbReference type="OrthoDB" id="93855at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="PTHR42786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004808">
        <property type="entry name" value="LasT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00050">
        <property type="entry name" value="rRNA_methyl_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="245" mass="28386" checksum="DFADCE809E52B988" modified="2011-05-03" version="1">MKVAVILVEPEYQMNIGFVARAMKNFDVKELILVNPPELRGEAYKFAMHAKDVLENAKIVKTVDEALKIVDVAVGTTGISGKVYLPERTPISPEEFAKRAFLYGGKIGIFFGRESKGLSNEELEKMDFTVTIPTSEEYPVMNLSHAVAVVLYEIYKQRVKAEISTEENRHLRKATREEKDILVKYWSELLETLNYPKDPIRRKYFTIMLRRVIGRSFIYAREIYSLYGPLRLAIEKIKRYENDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIU4</accession>
    <name>F0LIU4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467844.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01571"/>
    <dbReference type="EnsemblBacteria" id="ADT84546">
        <property type="protein sequence ID" value="ADT84546"/>
        <property type="gene ID" value="TERMP_01571"/>
    </dbReference>
    <dbReference type="GeneID" id="10041887"/>
    <dbReference type="KEGG" id="tba:TERMP_01571"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1571"/>
    <dbReference type="eggNOG" id="arCOG01754">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_2"/>
    <dbReference type="OMA" id="PHIAWAY"/>
    <dbReference type="OrthoDB" id="36410at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="3"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="106"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="307" mass="33930" checksum="2074F65154833706" modified="2011-05-03" version="1">MKVLVAAPLHPKAIELLKNEGFEVVYEEYPDEERLIELAKDVDAIIVRSKPKVTRKVIEAAEKLKVIGRAGVGLDNIDLEAAKEKGIEVVNSPAASSRSVAELTWALILAVARKVAFADRKMREGVWAKKQCMGIELEGKTIGIIGFGRIGYNVAKIAKGFGMRILLYDVIKNYERAEEVGGKFVELEELLKESDVVTIHVPLLDSTYHLIDEEKLKLMKKNAILINPARGPIVDTEALVKALKEGWIYGAGLDVFEEEPLPKDHPLTKLDNVVLTPHIGAGTWEAQERAGVQVVEKVVEILKQKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIV3</accession>
    <name>F0LIV3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467853.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01580"/>
    <dbReference type="EnsemblBacteria" id="ADT84555">
        <property type="protein sequence ID" value="ADT84555"/>
        <property type="gene ID" value="TERMP_01580"/>
    </dbReference>
    <dbReference type="GeneID" id="10041896"/>
    <dbReference type="KEGG" id="tba:TERMP_01580"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1580"/>
    <dbReference type="eggNOG" id="arCOG00449">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_0_2"/>
    <dbReference type="OMA" id="FLHKAPC"/>
    <dbReference type="OrthoDB" id="67791at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="157"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="280" mass="31508" checksum="D28165DA74CBCEC3" modified="2011-05-03" version="1">MFEKILFPTDFSEVSLHALRNCVPKFFELGAKKLYLVHIVDITATDIEALELMKIDEEQINNLADELRERGIEVESIVKLGIPSLEIAEIARERNVDLIISPSKGENILRQMFLGSTASNLVRATKKPVLLIRYEWDEEEEKIKCLHDCEKIFDKPLVALDFSPCSIRIMEAVKRFEELAKEGVLLHVVDYGKAEELEENIAKAKQNLERYAKIVKFPVEKEVLAGIASQGIIGLSIAKGATLIVMGKKGRSIIRDLLLGSTAERVIRDSKLPVLLVPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIV9</accession>
    <name>F0LIV9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA wyosine derivatives biosynthesis protein Taw3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">taw3</name>
        <name evidence="7" type="ordered locus">TERMP_01586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TYW3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467859.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01586"/>
    <dbReference type="EnsemblBacteria" id="ADT84561">
        <property type="protein sequence ID" value="ADT84561"/>
        <property type="gene ID" value="TERMP_01586"/>
    </dbReference>
    <dbReference type="GeneID" id="10041902"/>
    <dbReference type="KEGG" id="tba:TERMP_01586"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1586"/>
    <dbReference type="eggNOG" id="arCOG04156">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047426_2_0_2"/>
    <dbReference type="OMA" id="GFKYTTF"/>
    <dbReference type="OrthoDB" id="118297at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00266">
        <property type="entry name" value="TYW3_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022908">
        <property type="entry name" value="Taw3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSF111278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TYW3" evidence="6">
        <location>
            <begin position="5"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="205" mass="23416" checksum="A53F0E0D5A724027" modified="2011-05-03" version="1">MKAKREALVSLFTAMREKKVDEDIIDLLMLINSIRGVYTTSSCSGRIGIIEEPDLGAKPLSRWLIKEHRPITFEEAKESLKNAQRGFIFLKSQPPIFHIVAESIKIGKKLHELGLASGFKYTTFKAVKDRILVEINGTEYLTAPLGKDGRVLVDDVYLKFAVELGNSMLIRAKSRLPRLKENFEKLKEELGEDELFYEVKRKFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIX2</accession>
    <name>F0LIX2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00341"/>
    <dbReference type="EnsemblBacteria" id="ADT83318">
        <property type="protein sequence ID" value="ADT83318"/>
        <property type="gene ID" value="TERMP_00341"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00341"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.341"/>
    <dbReference type="eggNOG" id="arCOG05877">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3021172_0_0_2"/>
    <dbReference type="OMA" id="VRLMLNI"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="57" mass="6777" checksum="C80042A8ECC9315E" modified="2011-05-03" version="1">MSMKEEVEVLRRLAEKALKELDEAYKRIPDVNNGKTYLLRGKERVRLMLKILNDMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIX9</accession>
    <name>F0LIX9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-oxoglutarate oxidoreductase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466623.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00348"/>
    <dbReference type="EnsemblBacteria" id="ADT83325">
        <property type="protein sequence ID" value="ADT83325"/>
        <property type="gene ID" value="TERMP_00348"/>
    </dbReference>
    <dbReference type="GeneID" id="10040666"/>
    <dbReference type="KEGG" id="tba:TERMP_00348"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.348"/>
    <dbReference type="eggNOG" id="arCOG01599">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_0_0_2"/>
    <dbReference type="OMA" id="EHDGFAH"/>
    <dbReference type="OrthoDB" id="43666at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="57"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="PFO_beta_C" evidence="5">
        <location>
            <begin position="204"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="291" mass="33122" checksum="02603D9ACDADFF60" modified="2011-05-03" version="1">MNLDPKIFEPKRPGSQDVAWCPGCGNFGIRNILKRAFVELGLNPWEVVIISGIGQAAKMPHYINVHGYHTLHGRAIPIATAVKASNPELTVIAEGGDGDMYAEGGNHLIHAIRRNPNITVLIHDNQIYGLTKGQASPTTMLGMKTPTQPWGVFEEPFNPIALAVALNASFVARTFMGYFKESVEIIKEAIQHKGLAIVDILHPCVSFNKLNTYTWYREHTYWMKDHDPYDREEAFKRAVEKDLLPLGIFYINERPTFEEMSPAYKRDKTPLWKRVPKVEEIKRILDLKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIY9</accession>
    <name>F0LIY9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466633.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00358"/>
    <dbReference type="EnsemblBacteria" id="ADT83335">
        <property type="protein sequence ID" value="ADT83335"/>
        <property type="gene ID" value="TERMP_00358"/>
    </dbReference>
    <dbReference type="GeneID" id="10040676"/>
    <dbReference type="KEGG" id="tba:TERMP_00358"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.358"/>
    <dbReference type="eggNOG" id="arCOG01103">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119858_0_0_2"/>
    <dbReference type="OMA" id="MYSQMMH"/>
    <dbReference type="OrthoDB" id="77121at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="174" mass="20824" checksum="0FAE61A31F3B5445" modified="2011-05-03" version="1">MSLQEFEERYPFEKIKNFSLKELLEMAITSEIGAREFYESLASNIEIKPLKEKISWLAEEERKHEELLRRIHSEMFSGEEIKTPKEHIGPELKPVAKKLQDVKDIIDLIRWAMKAEEMAAQFYEELEKLVEGEEKKKLMRYLSDMEKSHYYALRAEYELLLDWSMYSQMMHIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ32</accession>
    <name>F0LJ32_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="5">HMG-CoA reductase</shortName>
            <ecNumber evidence="5">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466676.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00401"/>
    <dbReference type="EnsemblBacteria" id="ADT83378">
        <property type="protein sequence ID" value="ADT83378"/>
        <property type="gene ID" value="TERMP_00401"/>
    </dbReference>
    <dbReference type="GeneID" id="10040719"/>
    <dbReference type="KEGG" id="tba:TERMP_00401"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.401"/>
    <dbReference type="eggNOG" id="arCOG04260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001734_2_2_2"/>
    <dbReference type="OMA" id="DDKMTRA"/>
    <dbReference type="OrthoDB" id="26445at2157"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="PTHR10572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="SSF55035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="SSF56542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="408" mass="43810" checksum="9753E2E3AA56ACC8" modified="2011-05-03" version="1">MNIDEIIEKVVSGEIKLHQVEKYTNGDKKLATEIRRKALEKKFGISLEHIGHYSIDPNQVIGKNIENMIGVVQIPMGVAGPLRINGEYAKGEFYIPLATTEGALVASVNRGCSALTAAGGVKTTIIGDKMTRAPLLKCPDARRAREVAEWVKENIDYLQEVAVSKVTRHGKLKDVKPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEKFPDVKYLALSGNLCVDKKPNALNFILGRGKTVIAEAVIPREIVEKKLKTTPELIAEVNYRKNLVGSAQAGSYGFNAHFANIVGAIFLATGQDEAQITEGAHGITLAEVTPEGDLYISITMPSLEIGTVGGGTRVPPQREALSIMGVAGGGEPAGTNAKKFAEIIAGAVLAGELSLLAAIAAKHLAKAHKELGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ45</accession>
    <name>F0LJ45_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Threonine synthase</fullName>
            <ecNumber evidence="5 9">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">TERMP_00414</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5 9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466689.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00414"/>
    <dbReference type="EnsemblBacteria" id="ADT83391">
        <property type="protein sequence ID" value="ADT83391"/>
        <property type="gene ID" value="TERMP_00414"/>
    </dbReference>
    <dbReference type="GeneID" id="10040732"/>
    <dbReference type="KEGG" id="tba:TERMP_00414"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.414"/>
    <dbReference type="eggNOG" id="arCOG01434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_0_0_2"/>
    <dbReference type="OMA" id="MWGFQAS"/>
    <dbReference type="OrthoDB" id="16594at2157"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="60"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="10">
        <location>
            <begin position="223"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT83391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="391" mass="43020" checksum="61F838842ECEFD07" modified="2011-05-03" version="1">MLRCIECGKEYSEDEVRYRCECGGLLEIIIDLDKVENVFDGKNMTLWKYKSFIPVEKRVSLKEGGTPLYRLENLQKELEMRELYVKNEGANPTGSFKDRGMTVGVSKAIELGMDKVICASTGNTSASLAAYSAKAGIKSYVLVPSGKIALGKLAQAIVYGAKVVPVRGNFDNALRVVVEASRELGVYMLNSINPFRLEGQKTIAFEIFDQLGSVPDNVILPVGNAGNISAIWKGFKELYEAGFIDKLPRMIGIQAEGASPLAKAWKKKREFKPEEKPETVATAIRIGNPANWKKAWRAVEESGGLFESVSDEEILKAQKLLASKEGIFVEPASASSLAGLIKLKELNLIEPDESYVLITTGHGLKDPNIIIENFKLPEPIEPSLEAFKEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ55</accession>
    <name>F0LJ55_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADP-dependent malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01602</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467875.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01602"/>
    <dbReference type="EnsemblBacteria" id="ADT84577">
        <property type="protein sequence ID" value="ADT84577"/>
        <property type="gene ID" value="TERMP_01602"/>
    </dbReference>
    <dbReference type="GeneID" id="10041918"/>
    <dbReference type="KEGG" id="tba:TERMP_01602"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1602"/>
    <dbReference type="eggNOG" id="arCOG00853">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034446_2_1_2"/>
    <dbReference type="OMA" id="HKYAAVV"/>
    <dbReference type="OrthoDB" id="18649at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
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    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="6">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="5">
        <location>
            <begin position="170"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="444" mass="48287" checksum="5CD483C6B1EE46C6" modified="2011-05-03" version="1">MADNEQRKKLKEKALSFHRGNFPGNGKIEVIPKVSLKDKHDLSLAYTPGVAEPCKEIAKNPDDVYEYTSKGNLVAVVSDGSRILGLGNIGALAGLPVMEGKALLFKHFGGVDAFPIMIDEQDPDKFIEIVKAIAPTFGGINLEDIASPKCFYILERLRKELDIPVFHDDQQGTAAVVLAGLLNALKVVGKKLDETTIALFGAGAAGFATLRILTKAGVKPGNVRVVELVNGKPTVLTSDMDLEKLFPYRGWLLSKTNAEEITGGPEEAVNGADVLISFTKPGPGVIKPEWIAKMNDDAIVFPLANPVPEILPDEAKKAGAKIVATGRSDYPNQINNVLGFPGIFRGALDVRAKTITDTMIIEAAKAIASVVGDEELTEEYIIPSPLNPEVYPREARAVAEQAMKEGVARRKVSGEWVEEHTRKLREFYENVIAPVNKERKTWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ65</accession>
    <name>F0LJ65_THEBM</name>
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        <recommendedName>
            <fullName evidence="2">UPF0147 protein TERMP_01612</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0147 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01612"/>
    <dbReference type="EnsemblBacteria" id="ADT84587">
        <property type="protein sequence ID" value="ADT84587"/>
        <property type="gene ID" value="TERMP_01612"/>
    </dbReference>
    <dbReference type="GeneID" id="26137191"/>
    <dbReference type="KEGG" id="tba:TERMP_01612"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1612"/>
    <dbReference type="eggNOG" id="arCOG04308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165882_1_0_2"/>
    <dbReference type="OMA" id="RTIIWEV"/>
    <dbReference type="OrthoDB" id="116790at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00342">
        <property type="entry name" value="UPF0147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023130">
        <property type="entry name" value="Ta0600-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005354">
        <property type="entry name" value="UPF0147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03685">
        <property type="entry name" value="UPF0147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="86" mass="9838" checksum="4E379E200CD26031" modified="2011-05-03" version="1">MSDVEERINQIIQVLKEQVVQDTIVPRNIRRAAEEAIEHLMDRSKEPAVRAADAIAILEEISEDPNMPLHTRTIIWEVLGALEQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJA0</accession>
    <name>F0LJA0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84622">
        <property type="protein sequence ID" value="ADT84622"/>
        <property type="gene ID" value="TERMP_01647"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01647"/>
    <dbReference type="HOGENOM" id="CLU_3338671_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="37" mass="4171" checksum="8812F853ABFC038E" modified="2011-05-03" version="1">MKTTMINFPSKFKSFSFIAVAEHLKYLHGVLISGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJB4</accession>
    <name>F0LJB4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467934.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01661"/>
    <dbReference type="EnsemblBacteria" id="ADT84636">
        <property type="protein sequence ID" value="ADT84636"/>
        <property type="gene ID" value="TERMP_01661"/>
    </dbReference>
    <dbReference type="GeneID" id="26137141"/>
    <dbReference type="KEGG" id="tba:TERMP_01661"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1660"/>
    <dbReference type="eggNOG" id="arCOG00499">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074581_0_0_2"/>
    <dbReference type="OMA" id="HCHPDHY"/>
    <dbReference type="OrthoDB" id="107971at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="33"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="270" mass="30710" checksum="22BFDB281D1C5149" modified="2011-05-03" version="1">MIEITFLGSGGGRFITITQTRSTGGFFIKASKKIYVDPGPGALVRAWRYKIDPRRIDVLFVSHRHTDHCNDVEVMLEGITMGVTKKRGILIASKSVVHGDESHTPAVSQYHLDSLEEIHTPNPGDKFILGEEEMIITPAMHADPTTIGFRLRTKYGDISYIPDTQYFDELKKWHEGARVMIAAITRPKDMRIPYHLCTEDVIYMLKGMKDKPELLIMNHIGMKMHFANPYKEAKFIENVTGVKTLVAKEGFRVTIGKEIRLKTLRPARWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJB5</accession>
    <name>F0LJB5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetylornithine deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467935.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01662"/>
    <dbReference type="EnsemblBacteria" id="ADT84637">
        <property type="protein sequence ID" value="ADT84637"/>
        <property type="gene ID" value="TERMP_01662"/>
    </dbReference>
    <dbReference type="GeneID" id="10041978"/>
    <dbReference type="KEGG" id="tba:TERMP_01662"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1661"/>
    <dbReference type="eggNOG" id="arCOG01107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_2_2"/>
    <dbReference type="OMA" id="STFEPTM"/>
    <dbReference type="OrthoDB" id="14646at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010182">
        <property type="entry name" value="ArgE/DapE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01910">
        <property type="entry name" value="DapE-ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="4">
        <location>
            <begin position="204"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="413" mass="46654" checksum="984B7A3815524C32" modified="2011-05-03" version="1">MGEIIEKVSKEVEMLRDDMVQMLVELVRIPAISPDYGGEGEYDRAEKLLEIIRDWGFDRIERYDVPDERAKNGVRPNILAYYYGEKGEESQRLWILTHLDVVPPGEGWTVTEPFKPVIKDGKVYGRGSEDNGQSLVASLYAVKALMNLGIRPKRTIILAFVSDEETGSEYGIKWLIKNHPELFRKNDLVLVPDGGNEEGTFIEIAEKSILWMKIKFKGKQVHASMPDKGINAHRIALEYGYKLDKLLHEKYNAKDEIFDPPESTFEPTMGGNPSDAPNIASGEHEIVFDCRVLPKYNLDDILNDAKELAKEMEEKYRGAKIDIEVMQRVDAPEPTPKDSEIVKLLQNAIRILRNKEAKVGGIGGGTFAAYFRMLGIPAVVWCTCDETAHQPNEYAKIDNIVEDAKIMAILTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJD4</accession>
    <name>F0LJD4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="5">SDH</shortName>
            <ecNumber evidence="2 5">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">aroE</name>
        <name evidence="9" type="ordered locus">TERMP_00423</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="2 5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466698.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00423"/>
    <dbReference type="EnsemblBacteria" id="ADT83400">
        <property type="protein sequence ID" value="ADT83400"/>
        <property type="gene ID" value="TERMP_00423"/>
    </dbReference>
    <dbReference type="GeneID" id="10040741"/>
    <dbReference type="KEGG" id="tba:TERMP_00423"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.423"/>
    <dbReference type="eggNOG" id="arCOG01033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_3_1_2"/>
    <dbReference type="OMA" id="FGNPIKH"/>
    <dbReference type="OrthoDB" id="98644at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="7">
        <location>
            <begin position="11"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="6">
        <location>
            <begin position="111"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="8">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="5">
        <location>
            <begin position="19"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="127"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="149"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="272" mass="30171" checksum="E914155586B101DD" modified="2011-05-03" version="1">MINAKTRLYGLIGKPVEHSLSPVIHNALFKRYNINAVYLAFDVDDLESAVKGVKALGISGLNVTMPYKEQILEFLDELSEEARAIGSVNTVVNREGKLIGYNTDGIGALKALKRFTEVEGKRVLLLGAGGAGKAIAYTLSRLAKVVVLNRTERKAKELEKFGVKGGKLSKENLKRYLSWADIVINATSLGMNEDRSPIPKGLLRENLVVFDIVYSPLETNLLREAREVGCLTIDGLWMLIHQGAESFRLWTGVKPDVEFMRREALKGEKRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJF1</accession>
    <name>F0LJF1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine--tRNA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466715.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00440"/>
    <dbReference type="EnsemblBacteria" id="ADT83417">
        <property type="protein sequence ID" value="ADT83417"/>
        <property type="gene ID" value="TERMP_00440"/>
    </dbReference>
    <dbReference type="GeneID" id="10040758"/>
    <dbReference type="KEGG" id="tba:TERMP_00440"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.440"/>
    <dbReference type="eggNOG" id="arCOG00404">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_948696_0_0_2"/>
    <dbReference type="OMA" id="IFEVYSP"/>
    <dbReference type="OrthoDB" id="57287at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA-synt_His" evidence="2">
        <location>
            <begin position="7"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_His" evidence="2">
        <location>
            <begin position="188"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="296" mass="34415" checksum="3D4EA251BFBD01C1" modified="2011-05-03" version="1">MKKDLFSESERLADITKYLRRTFELWGYREIFLPTIEEFSGQLRKGTKFVYNNEFYVIKPDLTSQILANLKEPRRLKIYYISEVLNGGIKGDWQAGVEFIGGDDIKMQVEVLLTVITSLEALGIEDFYIDVGSLKVWERAIEGIEEFKAEIFRALTRRNFEIIERLPINEEKKEELWQLFNFRGKSCEYEKLNKIIEAVDDERVFIDFGTIRPLPYYSDIIFEVYSPRIGKPLGGGGEYTFKGASAFGFAFDLNALSKLFDGKIEKSRKRIRGKMKEAYKLARELVKLGIPVEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJG2</accession>
    <name>F0LJG2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-phosphoglycerate kinase</fullName>
            <shortName evidence="3">2PGK</shortName>
            <ecNumber evidence="3">2.7.2.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pgk2</name>
        <name evidence="6" type="ordered locus">TERMP_00451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2R)-2-phosphoglycerate + ATP = (2R)-2,3-bisphosphoglycerate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42408"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Thermoadapter biosynthesis; cyclic 2,3-diphosphoglycerate biosynthesis; cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 2-phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.16" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466726.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00451"/>
    <dbReference type="EnsemblBacteria" id="ADT83428">
        <property type="protein sequence ID" value="ADT83428"/>
        <property type="gene ID" value="TERMP_00451"/>
    </dbReference>
    <dbReference type="GeneID" id="10040769"/>
    <dbReference type="KEGG" id="tba:TERMP_00451"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.451"/>
    <dbReference type="eggNOG" id="arCOG01967">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_848909_0_0_2"/>
    <dbReference type="OMA" id="EMPFSKG"/>
    <dbReference type="OrthoDB" id="57277at2157"/>
    <dbReference type="UniPathway" id="UPA00551">
        <property type="reaction ID" value="UER00609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016774">
        <property type="term" value="F:phosphotransferase activity, carboxyl group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00769">
        <property type="entry name" value="2PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020872">
        <property type="entry name" value="2PKG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-cone" evidence="5">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="299" mass="34689" checksum="625028DBB1EF4A72" modified="2011-05-03" version="1">MIIVIDKERKTELPFSRGILTRSITSAGVEVGIAYSIATEVMKHFMEMRKKKVTKDDIREITYEKLVEHGLKEEAKRYLFWRRLKKLKFPMIILIGGTTGVGKSTISTELAFRLGMRTIIGTDTVREVMRKIIAKELIPAIHTSSFLAWKEIENFPKGVSPLIYGFETQVRHVAVGVNAVIERSYTEGFNTIIEGIHLVPGYIKLNDRSFMYLIVVKDKDSLKARFYERTRYSLRPAEYYLKNLDEIMEIQEFLIEKAKEHGIPIIENVELEKTVNAIMERLMEEVLGRLKERGIEIWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJH7</accession>
    <name>F0LJH7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00466"/>
    <dbReference type="EnsemblBacteria" id="ADT83443">
        <property type="protein sequence ID" value="ADT83443"/>
        <property type="gene ID" value="TERMP_00466"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00466"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.466"/>
    <dbReference type="eggNOG" id="arCOG07085">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169423_0_0_2"/>
    <dbReference type="OMA" id="FCERARM"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="106" mass="13478" checksum="AFCB84F68F12E25D" modified="2011-05-03" version="1">MEIEIRVTNDEFQKIRKEKKEIKRRFYELEKLEKTLQILEINYLLEKRRRLEEKLKEMEEHYQMLLKFSEKAKKDKEKMKEFRLKLSIENRELRREMKRDENRGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJH8</accession>
    <name>F0LJH8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466742.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00467"/>
    <dbReference type="EnsemblBacteria" id="ADT83444">
        <property type="protein sequence ID" value="ADT83444"/>
        <property type="gene ID" value="TERMP_00467"/>
    </dbReference>
    <dbReference type="GeneID" id="10040785"/>
    <dbReference type="KEGG" id="tba:TERMP_00467"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.467"/>
    <dbReference type="eggNOG" id="arCOG09854">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1237978_0_0_2"/>
    <dbReference type="OMA" id="MENFLYE"/>
    <dbReference type="OrthoDB" id="67637at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045706">
        <property type="entry name" value="DUF6062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19538">
        <property type="entry name" value="DUF6062"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="234" mass="27078" checksum="57FBBF8CEA69530C" modified="2011-05-03" version="1">MDLIGIYLREAFQGTGCPICRIVEKYEREVIGHILYEHINSPSVREKFSESLGLCPYHAWKLKDIAYSNPLYGGLGVAIIYEHMLSIYLNALKDEKKIEDGKCYLCELTEVKEKHTVEATVDRMDKLIEDYRNSEAILCKKHFEEIEVKLRRKNPELAEELKKVQIGKLEKIKTLMHLFIEKFDYRATKAPTEQEASSVPKAIESLKGLPLQINFVKRQKQHSILRGVLLGNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJI3</accession>
    <name>F0LJI3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CRISPR-associated helicase Cas3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TERMP_00472</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466747.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00472"/>
    <dbReference type="EnsemblBacteria" id="ADT83449">
        <property type="protein sequence ID" value="ADT83449"/>
        <property type="gene ID" value="TERMP_00472"/>
    </dbReference>
    <dbReference type="GeneID" id="10040790"/>
    <dbReference type="KEGG" id="tba:TERMP_00472"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.472"/>
    <dbReference type="eggNOG" id="arCOG01443">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01444">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_367100_0_0_2"/>
    <dbReference type="OMA" id="QVIEVGM"/>
    <dbReference type="OrthoDB" id="9047at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF5">
        <property type="entry name" value="PTHR47959:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="234"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="HD Cas3-type" evidence="11">
        <location>
            <begin position="553"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT83449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="758" mass="87054" checksum="1367B386E718058E" modified="2011-05-03" version="1">MSEIERRFRQVTGFTPYDFQKEAIEYLLDGYSLIVRAPTGAGKSEMVLIPFISELNESLPSQLIYSLPNRTLVESLGNRAKRYASFKKLRVAVHHGKRVESRLFEEDIIITTIDQTAGAYLSVPLSMPKKWGNIFVGGVASSMLVFDEVHTLHPEKGLLTSVAMSIESSKLGFPFVMMSATLPESFMEKVKKMAEKKGGKVNIISVDDENEIASRKARKIYLDTSPLYSKTSLTAEEVLKHLEDSKNLLIVVNTVSKAQKLYLDLKDKIDVPLLLLHSRFLEEDRQAKERTVLEIFGKKQREGILITTQVIEVGMDISSSKLLTEISPIDSLIQRAGRVARWGGEGEVIVYDVEKKPGKPYAPYSEELVEPTIQALKGVELLNWQAEVMLVDKVLSKPFENYLDPYKFYERLGGLVRAVYEGKRAYVEENVREAYSVEIALYENVEELKGEPEKAFALKRLRVDFRVLAGKFNYLQEIGAKIYRVEENPLIDEYESKYELVEVQSKEDIMPFEFYIISGISYSPEVGLLFDKSGEIKSFEFEEKEHLFKLELKELRRETWVEHSLKTLDFLRTYMLPRYAYPIKTFAKYFGISKKDLISWIELSVALHDLGKLNYYWQKAAGWQKGEEPIAHGFERIKKLPPHATVSAKALEPYLMEQFDEEGLFKAFYLAIAHHHSPWSSKYQKFKLIEDAQEYIFSIYPIPDDLILRKSPSGSFPFKLNIDDENEYYRLYGLVSKLLRISDRLATGGESYESIFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJJ5</accession>
    <name>F0LJJ5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protease IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466759.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00484"/>
    <dbReference type="EnsemblBacteria" id="ADT83461">
        <property type="protein sequence ID" value="ADT83461"/>
        <property type="gene ID" value="TERMP_00484"/>
    </dbReference>
    <dbReference type="GeneID" id="10040802"/>
    <dbReference type="KEGG" id="tba:TERMP_00484"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.484"/>
    <dbReference type="eggNOG" id="arCOG01311">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046540_0_1_2"/>
    <dbReference type="OMA" id="GVVLWIE"/>
    <dbReference type="OrthoDB" id="36138at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="4">
        <location>
            <begin position="153"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="338" mass="38060" checksum="2732C82B478F005C" modified="2011-05-03" version="1">MDKEEVWKYLTFILTLLLALAIVSNVLLYTQNSELQKALVVNRTTEVKVEMPNITVKTSVGNITALQAKIEELQRQVEYLKEQLREKQPAKANTTIAILPIMGPIDENMALDVVSKIRQIKENESIGGVLLWIESPGGYVGPVRVIYKELKKLSYSKPVVAYTGGYADSGGYFIACAADKIIADPLAEVGSIGVLYVHYDLEQYYAQNGIKVNVFKTGKYKDMGAEWRDLTPEEREMIKNIIDTYFQDFLQVVSEGRHLDMNTTKKYATGQTWFATDVKGILVDDTGDLDYAIKVLEQLMNVKSAKVVLYSAQKTDFGIYESSSLYMPANYVYSYIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJL6</accession>
    <name>F0LJL6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide transport ATP-binding DppF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467956.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01683"/>
    <dbReference type="EnsemblBacteria" id="ADT84658">
        <property type="protein sequence ID" value="ADT84658"/>
        <property type="gene ID" value="TERMP_01683"/>
    </dbReference>
    <dbReference type="GeneID" id="26137118"/>
    <dbReference type="KEGG" id="tba:TERMP_01683"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1682"/>
    <dbReference type="eggNOG" id="arCOG00184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="GRYPHMF"/>
    <dbReference type="OrthoDB" id="41087at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="335" mass="38184" checksum="4C01D2412DDDCBB5" modified="2011-05-03" version="1">MAEPILKVENLKKYFPIKRGLLGALRGEPPRFVRAVDGVSFEVHKQEVFALVGESGCGKTTTGKLVMKLLEPTDGRIYLEGKDVTELKTQEEIKAYRRKVQMIFQDPFSSMNPRFRIYDVLEEPLLIHGIGETRAEREELIYKALEMVKIVPPEDYVGRHPHMLSGGQRQRVAIARALILNPTFIVADEPVSMLDVSIRAEILELMKELKEKMGVTYLYITHDLSTARYFADWIAVMYLGRIVEMGPAKVVIDNPIHPYTRALLAAVPEPIPERRNIIKELPIKGEVPSAVNIPPGCRFHPRCVYMEKGLCDVKHPQLIEYEHNHWVECHLAGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJN5</accession>
    <name>F0LJN5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">V-type ATP synthase subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467975.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01702"/>
    <dbReference type="EnsemblBacteria" id="ADT84677">
        <property type="protein sequence ID" value="ADT84677"/>
        <property type="gene ID" value="TERMP_01702"/>
    </dbReference>
    <dbReference type="GeneID" id="26137097"/>
    <dbReference type="KEGG" id="tba:TERMP_01702"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1701"/>
    <dbReference type="eggNOG" id="arCOG03363">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160668_2_0_2"/>
    <dbReference type="OMA" id="IDAECER"/>
    <dbReference type="OrthoDB" id="123647at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014275">
        <property type="entry name" value="ATPase_A1A0-cplx_hsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02926">
        <property type="entry name" value="AhaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="103" mass="11781" checksum="D9F2996358BEDD22" modified="2011-05-03" version="1">MEEVIKQIVEAEKQAKERIEKAKEEAKLIIQKAKEEAKELESKIIAEAEEKAKVVIEQKKKEGEIEANKLIEEGNRELEELKVRATENLEKAIDESIKLIRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJR0</accession>
    <name>F0LJR0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468000.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01727"/>
    <dbReference type="EnsemblBacteria" id="ADT84702">
        <property type="protein sequence ID" value="ADT84702"/>
        <property type="gene ID" value="TERMP_01727"/>
    </dbReference>
    <dbReference type="GeneID" id="10042043"/>
    <dbReference type="KEGG" id="tba:TERMP_01727"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1726"/>
    <dbReference type="eggNOG" id="arCOG00910">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074702_1_0_2"/>
    <dbReference type="OMA" id="DVVYSIH"/>
    <dbReference type="OrthoDB" id="119044at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="208" mass="23415" checksum="5FB32C500397C75A" modified="2011-05-03" version="1">MKKKHLAMLLSRLKGFENPKAELEQYRTPGNVAAELLWLAYSLGDVEGKVIADLGAGTGVLSVGACLLGAKKVYAVEIDESALKIAEENVKALSVETCVELILSDVSFFDKQADAVIMNPPFGSQNPKADRPFLLKAFEISKVVYSIHLAKPEVRKFIEAFVRDNGFTITHRLTVDFEIPAQFFFHRKRLERIKVDIYRFERAQPTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJT2</accession>
    <name>F0LJT2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01749"/>
    <dbReference type="EnsemblBacteria" id="ADT84724">
        <property type="protein sequence ID" value="ADT84724"/>
        <property type="gene ID" value="TERMP_01749"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01749"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1748"/>
    <dbReference type="eggNOG" id="arCOG09530">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3057323_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="53" mass="6540" checksum="C7D3E18370B7C01A" modified="2011-05-03" version="1">MIFHLLALWRYREKAKSIPYGDESRSLEVEELLRKFDRVIKEMKKEGYQHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK14</accession>
    <name>F0LK14_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466849.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00574"/>
    <dbReference type="EnsemblBacteria" id="ADT83551">
        <property type="protein sequence ID" value="ADT83551"/>
        <property type="gene ID" value="TERMP_00574"/>
    </dbReference>
    <dbReference type="GeneID" id="10040892"/>
    <dbReference type="KEGG" id="tba:TERMP_00574"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.575"/>
    <dbReference type="eggNOG" id="arCOG00696">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046987_1_0_2"/>
    <dbReference type="OMA" id="HCTEGHK"/>
    <dbReference type="OrthoDB" id="44408at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="237"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="380" mass="42990" checksum="7FFBB409BBF8041B" modified="2011-05-03" version="1">MKAVKATLLYDGLGNLKKNIYIVFDKEIKKITKEKPKDAEIIAEGVVTPAFIDGHSHIGMERYGEPYQEGEANEQMDSVLPLVDALYSIYMDDKAFKHSIEFGVLYSSVLPGSGNIIGGRAVLIKNYGRDIEDAFMKYVGVKAAFGYNPRSTKEWKGTRPSTRMGAIGILLNWLIKTQKTIALLEKGKKEPEEIEPTVEALIPVLKGEEPLRVHVHKEDDIAALLMIKRKFGLKITIEHAGDVHSKETFEKIKKENVPLIYGPFDSLPYKVELKHEDWKNAKYLIEVKPLFGLMSDHPVTLQANLYLQLRHFIRLGMSKEEAIKIITHNNAKILGVDDILGSIEKGKWASLVVWNGDPFHMESYPTHVFAEGKLIHEWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK45</accession>
    <name>F0LK45_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPF0165 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468053.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01782"/>
    <dbReference type="EnsemblBacteria" id="ADT84757">
        <property type="protein sequence ID" value="ADT84757"/>
        <property type="gene ID" value="TERMP_01782"/>
    </dbReference>
    <dbReference type="GeneID" id="26137295"/>
    <dbReference type="KEGG" id="tba:TERMP_01782"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1781"/>
    <dbReference type="eggNOG" id="arCOG08303">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200885_3_0_2"/>
    <dbReference type="OrthoDB" id="128231at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008203">
        <property type="entry name" value="AF2212-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024069">
        <property type="entry name" value="AF2212-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01954">
        <property type="entry name" value="DUF104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="66" mass="7677" checksum="0055CB817683D45E" modified="2011-05-03" version="1">MVTKIVAVYENGVLKPKKKLNLPEGMEVELIIKPSIKELLKAFENVEVKEDVERALKEGRERKIWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK62</accession>
    <name>F0LK62_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin_Reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468070.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01799"/>
    <dbReference type="EnsemblBacteria" id="ADT84774">
        <property type="protein sequence ID" value="ADT84774"/>
        <property type="gene ID" value="TERMP_01799"/>
    </dbReference>
    <dbReference type="GeneID" id="10042115"/>
    <dbReference type="KEGG" id="tba:TERMP_01799"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1798"/>
    <dbReference type="eggNOG" id="arCOG02017">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_5_3_2"/>
    <dbReference type="OMA" id="WAMPLDF"/>
    <dbReference type="OrthoDB" id="76604at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="171" mass="19433" checksum="7F269D886BF22CD9" modified="2011-05-03" version="1">MDAYRLLYPMRTYLIVSGHGEEANVMAADWVTILSHEPFMVGVAVSPKRYTHRLISKYREFIVSVPSLDMLRDVWIAGTKSGPSKLKEMSITLVPSTKIETPSIKEALANIECKVIDARDYGDHTWFVGEVVGWSYNEKAFKNGKPNLEAKFLAHAAWTDFVTFDKKIHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKA1</accession>
    <name>F0LKA1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466857.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00582"/>
    <dbReference type="EnsemblBacteria" id="ADT83559">
        <property type="protein sequence ID" value="ADT83559"/>
        <property type="gene ID" value="TERMP_00582"/>
    </dbReference>
    <dbReference type="GeneID" id="10040900"/>
    <dbReference type="KEGG" id="tba:TERMP_00582"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.583"/>
    <dbReference type="eggNOG" id="arCOG03805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063611_0_0_2"/>
    <dbReference type="OMA" id="AFEDQQW"/>
    <dbReference type="OrthoDB" id="77863at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008553">
        <property type="entry name" value="DUF835"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05763">
        <property type="entry name" value="DUF835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="DUF835" evidence="2">
        <location>
            <begin position="236"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="365" mass="41505" checksum="42D64F8DA41FE637" modified="2011-05-03" version="1">MLGIPLYILAEVLLVMTLDLLAFVFVFRAYLKTKRKSALVFSFAWLSDFLTILFAGFNMYVLNSFFIALFGALITYGILIFLEEEKETLPLTQVQKATVLPPLFVIYLVLLKNYAGINEWTLIVGGSWFLAGGFLIFAGIFLRNLVNVYEKSVRYLYYGFVLFGLHLLPYPFFAREEWYAPIGLTASTVLIVFLTTTMIRLVLSPRFTKLYEIPAESKARKIDLKPGVLIVNQNEYKQLELKLKDMPALAFLRNITNVPEKWEYFFVTTVTKDGSQKVVSPTDLAKITELTYRYLKAAADTNTPGIVIIDCLEYLLVYNEPTSVMKFLTKLRDLILVHKATLILVAEKSALGDKNWALLTKLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKA3</accession>
    <name>F0LKA3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TERMP_00584</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00584"/>
    <dbReference type="EnsemblBacteria" id="ADT83561">
        <property type="protein sequence ID" value="ADT83561"/>
        <property type="gene ID" value="TERMP_00584"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00584"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.585"/>
    <dbReference type="eggNOG" id="arCOG01185">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG10111">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063953_2_0_2"/>
    <dbReference type="OMA" id="VECSITM"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="PTHR12209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="100"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT83561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="323" mass="38131" checksum="B6ACFE39786F92B9" modified="2011-05-03" version="1">MEEVKIYEIRKDNIRAMLKEIAEYNLADIEVENRASLVDDMLKSPGDRLSYALQKLEENDVDTARFVIKDDAGILIVKIDDIITIRISLRILGLLQIKRVVLMELIKQGAEAKIYLAKFEELYFPFNGEKVIIKHRISKRYRIKEIDQKLRKERTVREARILHRAKKFGVNVPYIYEVDLKDMKIVMEFIEGERLKEYLERIPIEERLKFCREIGRQIGKLHEAGIVHGDLTTSNMILRDGKIYLIDFGLAEFDNTLEAQGVDLHLLKRAMESTHYKWFEEGFEAVLEGYVEVRGEEKAQKLKEKIEEIESRGRYVRERKWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKF1</accession>
    <name>F0LKF1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00632"/>
    <dbReference type="EnsemblBacteria" id="ADT83609">
        <property type="protein sequence ID" value="ADT83609"/>
        <property type="gene ID" value="TERMP_00632"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00632"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.634"/>
    <dbReference type="eggNOG" id="arCOG10341">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103231_0_0_2"/>
    <dbReference type="OMA" id="DEKNALW"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="189" mass="21351" checksum="F4B1A0EBBBB71816" modified="2011-05-03" version="1">MLGGVKYGEMKQNPEKVADEIISAARERGIPVKNEDKEKIITAIQKASKIVDKLTGDVSEEKLDALYQALAEKTDDPLYILKRNGIDIEPELEEFRQFLAEISGRKTETEDLKVRTPKTGIPSEVLAIVKGLEFADFSENAMQKAEKELLELIDGLLDDEKNALWVFYAVKLLRLIQRKDLGGIKKFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKF5</accession>
    <name>F0LKF5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyacylglutathione hydrolase-like protein, glyoxalase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00636"/>
    <dbReference type="EnsemblBacteria" id="ADT83613">
        <property type="protein sequence ID" value="ADT83613"/>
        <property type="gene ID" value="TERMP_00636"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00636"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.638"/>
    <dbReference type="eggNOG" id="arCOG00504">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_5_1_2"/>
    <dbReference type="OMA" id="FNTHEHF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="229" mass="26440" checksum="9DDFBEDA05D30C14" modified="2011-05-03" version="1">MIPIEIPPNTVMLKGIGWDSNIYLVRDENEALIIDTGTGVYWHKYIDIWLNENYLKGAEKITIFNTHEHFDHVGGNMAFRRYFEERGIKVYFAAHKYTAEALERGDDYVILSFYHGRSYTPHEVHLKLSGGEALRVGNLELIVIHTPGHTRGSVCLYEPNEKLLFTGDTIFNKTVGRTDFPTGSLEMLKKSLQKLEKLDVYLGLPGHGRVIKNWKENLEYIKHLLEDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKG9</accession>
    <name>F0LKG9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466925.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00650"/>
    <dbReference type="EnsemblBacteria" id="ADT83627">
        <property type="protein sequence ID" value="ADT83627"/>
        <property type="gene ID" value="TERMP_00650"/>
    </dbReference>
    <dbReference type="GeneID" id="10040968"/>
    <dbReference type="KEGG" id="tba:TERMP_00650"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.652"/>
    <dbReference type="eggNOG" id="arCOG05812">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1599099_0_0_2"/>
    <dbReference type="OMA" id="ESKWDEL"/>
    <dbReference type="OrthoDB" id="76489at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="167" mass="19895" checksum="437A703562A405D2" modified="2011-05-03" version="1">MTGTISKIVRFEDEEEFLMDMENIMERFTYLTSRYGGGNVIEGFLLWDYVGIQDDEGIKIFRIGEFPYIEGTLKVDYETLRILERYFDEIESRWSDLSVEEIDYFIRMLNEALEREIVFYEAYDLGLNRDEAYLILNIKALHYLDRVVDAEDREVLEEAVGLLMKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKI3</accession>
    <name>F0LKI3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468113.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01842"/>
    <dbReference type="EnsemblBacteria" id="ADT84817">
        <property type="protein sequence ID" value="ADT84817"/>
        <property type="gene ID" value="TERMP_01842"/>
    </dbReference>
    <dbReference type="GeneID" id="10042158"/>
    <dbReference type="KEGG" id="tba:TERMP_01842"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1841"/>
    <dbReference type="eggNOG" id="arCOG00894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052035_0_0_2"/>
    <dbReference type="OMA" id="IPSYNNA"/>
    <dbReference type="OrthoDB" id="41009at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="380" mass="42899" checksum="16A8FFE370ACDD5B" modified="2011-05-03" version="1">MKVMVGIPSYNNADTIGFVVKQAAEGLKKYFGGGIIANADGGSNDGTREVVMKTRVPEGVEVMSFVYKWPIPGKGSAMKELMELAKEKGVDVLVFVDSDLRSITPEWIYKFAKPVEDGYDFVAPLYIRHKYDGTITNNIAYPMTASLYGYNVRQPIGGDFGISAKLIDVYLADEEVWKTDVARFGVDIFLTTTALAEGFRVVQTALGLKIHNPKDPAASLGPMFNQVVGTLFMLMKKYEEKWKPVKNIRDVEVFGEIQWKEPEEVKVTLELLKQKAKELFKENEAILKKALSEETFTQVTKALETFELDDVLWSHILFDGAVAYKRGILKNAEPLIPLYFAKTADFVEKTRELTTAEAEKIIQERAKVFLEEKDYLLEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKK4</accession>
    <name>F0LKK4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA double-strand break repair protein Mre11</fullName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mre11</name>
        <name evidence="7" type="ordered locus">TERMP_01863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Nuclease activity is regulated by Rad50.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468134.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01863"/>
    <dbReference type="EnsemblBacteria" id="ADT84838">
        <property type="protein sequence ID" value="ADT84838"/>
        <property type="gene ID" value="TERMP_01863"/>
    </dbReference>
    <dbReference type="GeneID" id="10042179"/>
    <dbReference type="KEGG" id="tba:TERMP_01863"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1862"/>
    <dbReference type="eggNOG" id="arCOG00397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026621_5_2_2"/>
    <dbReference type="OMA" id="YRQYNLD"/>
    <dbReference type="OrthoDB" id="25870at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02044">
        <property type="entry name" value="Mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032885">
        <property type="entry name" value="Mre11_archaea-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="6">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="380" mass="43426" checksum="EE7E6564ED82E18B" modified="2011-05-03" version="1">MRIAHISDTHLGYRQYNLDERENDIYDAFNEAIDIIIEERVDVVIHAGDFFDTPRPPIKALYVAKEAIKRLHENGVKILTVLGEHDTPKRRAMPPHKLLDIPILGIGEVNVVEVNGVGFFGISNMKGKRVDLLKQELSKVDALANRYSKAVLIAHQGIKKYLPFEGAYELELGDLPKEIDYYAFGHIHRRTFEKFGRGYLAYSGSIEILSRSEITDWKRDGKGIYIVDLEGDLPEVHKISLQQIRPQFELSYSEGDVIEELKAFLYNLLKNPLDKSPILRINISGEGIRKPEILEKVQYLLRKMVPEKVLRYDVHFVGSDAPITITAEELGKIVDLEELFIEYLGDETLGHLAFELYKSLQYGDVEGGIEICKEYLEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKQ4</accession>
    <name>F0LKQ4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal heat shock regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466931.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00656"/>
    <dbReference type="EnsemblBacteria" id="ADT83633">
        <property type="protein sequence ID" value="ADT83633"/>
        <property type="gene ID" value="TERMP_00656"/>
    </dbReference>
    <dbReference type="GeneID" id="26136056"/>
    <dbReference type="KEGG" id="tba:TERMP_00656"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.658"/>
    <dbReference type="eggNOG" id="arCOG01684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077589_0_0_2"/>
    <dbReference type="OMA" id="CTECYFS"/>
    <dbReference type="OrthoDB" id="87825at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="229" mass="26767" checksum="B44AE9B9F0843109" modified="2011-05-03" version="1">MSEPDIFYILGNKVRRDLLSHLTCTECYFSLLSNKVSVSSTAVSKHLKIMEREGLLKSYEKEGKFIGPVRKYYKITLSSTYVVTVTPNLFWYRGIKLDEKPKLKRFEIDLENLEESPNTLQSMVLNLIDANKQLHILLEALKSLESYRDMLVKTIKERYLEEIGDMTQLAILHYLMLYGEATIEDLSDRLNIKEREVIKKAEELNKFVPLTIKDRTIKIDEEKLRKVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKT9</accession>
    <name>F0LKT9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466966.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00691"/>
    <dbReference type="EnsemblBacteria" id="ADT83668">
        <property type="protein sequence ID" value="ADT83668"/>
        <property type="gene ID" value="TERMP_00691"/>
    </dbReference>
    <dbReference type="GeneID" id="26136093"/>
    <dbReference type="KEGG" id="tba:TERMP_00691"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.692"/>
    <dbReference type="eggNOG" id="arCOG01723">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105244_2_0_2"/>
    <dbReference type="OMA" id="QHPCRDF"/>
    <dbReference type="OrthoDB" id="123503at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="PTHR21028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00318">
        <property type="entry name" value="cyaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="184" mass="21836" checksum="5C60F8FD0FEEE661" modified="2011-05-03" version="1">MIEIELKGYANDRIFEKVRGRFEFMRKEMHEDIYYQHPCRDFSKTDEALRIRIKRFNGHFEAFLTYKGPKLDDMSKTRKEIEVPISDVDAYSDLLTSLGFEKVLTIVKVREKYYVEKGVTITLDEVEGLGKFIEIEKLVKEEKDIKNEVKKLRGILEDLGVERFERRSYLELLLEKLKKNGSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKU8</accession>
    <name>F0LKU8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 12">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">uppP</name>
        <name evidence="13" type="ordered locus">TERMP_00700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 12"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466975.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00700"/>
    <dbReference type="EnsemblBacteria" id="ADT83677">
        <property type="protein sequence ID" value="ADT83677"/>
        <property type="gene ID" value="TERMP_00700"/>
    </dbReference>
    <dbReference type="GeneID" id="26136103"/>
    <dbReference type="KEGG" id="tba:TERMP_00700"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.701"/>
    <dbReference type="eggNOG" id="arCOG04761">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060296_1_2_2"/>
    <dbReference type="OMA" id="IEGPFRD"/>
    <dbReference type="OrthoDB" id="104282at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT83677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="270" mass="29501" checksum="ED537A163CAC20E9" modified="2011-05-03" version="1">MNYIEAVIMGILQGFTEWLPISSSGQVMLAMMNFFGISPEKAYSYALLLHFGTLFAVLFKFRYELGRILMNLVTLRWGEEETFLFYSTLFTAVIGLPLYRAFKTIVTSLNAEAVNGIVGFALILTGVILAKSREKPKDEFGQIVRKKRKKEVTIVEAMVAGIAQGIAVLPGISRSGMTIGALLLLGVDQKKAVRLSFLMAVPAIFGALFLELQAVSEPITVSLVAVLSAFIVSLLTLEGMLKLAERLNFSKFCIVFGSIAVVVSIMGVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKW4</accession>
    <name>F0LKW4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Valine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Valyl-tRNA synthetase</fullName>
            <shortName evidence="6">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">valS</name>
        <name evidence="10" type="ordered locus">TERMP_00716</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466991.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00716"/>
    <dbReference type="EnsemblBacteria" id="ADT83693">
        <property type="protein sequence ID" value="ADT83693"/>
        <property type="gene ID" value="TERMP_00716"/>
    </dbReference>
    <dbReference type="GeneID" id="10041034"/>
    <dbReference type="KEGG" id="tba:TERMP_00716"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.718"/>
    <dbReference type="eggNOG" id="arCOG00808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_2"/>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="OrthoDB" id="4914at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02005">
        <property type="entry name" value="Val_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022874">
        <property type="entry name" value="Valine-tRNA_ligase_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="8">
        <location>
            <begin position="14"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="9">
        <location>
            <begin position="612"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="6">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="6">
        <location>
            <begin position="531"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="534"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="887" mass="103661" checksum="B58776A40E1BC6D8" modified="2011-05-03" version="1">MLPKNYNPEEVETKWQRFWLDEKIYKYELDEKKPPYAIDTPPPFTSGTLHLGHVLSHTWIDIVARYKRMRGYNVLFPQGFDNHGLPTELKVEKEFGISKDEPEKFLQKCIEWTWQAIEAMRNQFIRIGYSADWDLEYHTMDDEYKALVQKSLLEFYKKGLLYQAEHPVFWCPNCRTSLAKAEVGYVEEDGFLYYIKLPLADGNGYIPIATTRPELMPACVAVFVHPEDDRYKDLVGKKVKLPIFEREVPILADEDVDPSFGTGAVYNCTYGDEQDIVWQKRYNLPVIIAIDEYGRMTEVAGKYKGMKTEEAREAIAKDLEEMGLLYKKEKIRHRVLRHTERSSCMAPIELLPKKQWFIKVKEFTEELVEVARQIRWFPEDMFLRLKDWAESMDWDWVISRQRVFGTPIPFWVCKDCGHIIPAREEDLPVDPRFDKPPVEKCPKCGSANLEGVRDVLDCWIDSSITPLVITKWTKDEKWFKHNFPTALRPQGTDIIRTWAFYTIFRTYILTGQKPWHDILINGMVAGPDGRKMSKSYGNVVSPEEVIPKYGADALRLWTALAPPGEDHPFKWETVDYNFRFLQKLWNIFRFAERHIKDLDYNANKNIKLEPLDRWILSRLHRLIKFATNEMEIYRFNLLTRELMTFIWHEVADDYLEMIKHRLYGEDKESKLKARVALYELLYNILLLLAPFVPHITEELYQEVFKDKVGAKSIHLLEWPAYNEARIDEEAEKLGELAREIIGAMRRYKNSHGLALNAKLKHVAIYATDSYEMLKAIEKDIAGTMNIEKLEIVKGEPELEERIVEIKPNFRTVGPRYGKLVPKIVAYLKQNAEEVSKALKESGKVEFEVEGQKVELSKDDIVLRKAVFSEGEEVETAVVGDAVILFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKY4</accession>
    <name>F0LKY4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geranylgeranyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468187.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01916"/>
    <dbReference type="EnsemblBacteria" id="ADT84891">
        <property type="protein sequence ID" value="ADT84891"/>
        <property type="gene ID" value="TERMP_01916"/>
    </dbReference>
    <dbReference type="GeneID" id="10042232"/>
    <dbReference type="KEGG" id="tba:TERMP_01916"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1915"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_0_1_2"/>
    <dbReference type="OMA" id="IGVHMDR"/>
    <dbReference type="OrthoDB" id="115808at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="371" mass="41859" checksum="012443657BFD6881" modified="2011-05-03" version="1">MKYDIVIIGGSVVGSYLATLLARHYRIAVIEAKSSFGGKACTGIIGAKSYEELKLPKDAIINKLRGAVFYSKIQSFEIERKEPQAYMVDRKILEKSLAERAVKRGAEYYMNTRFLGFRNGKAVLQRFNDRFEINADFYIGADGVNSKVAQEIGAKTKAEFLSGYEVEIVGEFEKPDFVELWVNKELNEDFFFWVAPINESLARVGTFGRLDALFNFIRARMLKETNIVEFKAGSVALGVRKPWVKGNVALVGDAALQIKPLTAGGIAYGMYCAYALAYSLINGKPEDYERLCKNIKREISFGLKARRLFKNLNQEQIEKLFEVLSSREAIEVIESTADFDEHAKTIKALIKHPKLLARALKVTPMIIRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKZ7</accession>
    <name>F0LKZ7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468200.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01929"/>
    <dbReference type="EnsemblBacteria" id="ADT84904">
        <property type="protein sequence ID" value="ADT84904"/>
        <property type="gene ID" value="TERMP_01929"/>
    </dbReference>
    <dbReference type="GeneID" id="10042245"/>
    <dbReference type="GeneID" id="26137469"/>
    <dbReference type="KEGG" id="tba:TERMP_01929"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1928"/>
    <dbReference type="eggNOG" id="arCOG01848">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_9_1_2"/>
    <dbReference type="OMA" id="MFANDMF"/>
    <dbReference type="OrthoDB" id="93082at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="201" mass="22407" checksum="A47179A4E58FFA4B" modified="2011-05-03" version="1">MSQKYFVHPTAVVEDEVEIGEGTRIWHFAHIRKGAKIGKNCNIGKDVYIDVGVEIGNNVKIQNGVSVYRGVKVEDDVFLGPHMTFTNDLYPRAFSEDWELVPTLVKKGASIGAHATIVCGVTIGEYAMVGAGAVVTKDVPPFGLVYGNPARLKGFVCYCGRKLKEKIGEDENHIIFKCSHCGREVKIRKEDYERYLKEKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKZ8</accession>
    <name>F0LKZ8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01930"/>
    <dbReference type="EnsemblBacteria" id="ADT84905">
        <property type="protein sequence ID" value="ADT84905"/>
        <property type="gene ID" value="TERMP_01930"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01930"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1929"/>
    <dbReference type="eggNOG" id="arCOG01405">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01406">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_11_2_2"/>
    <dbReference type="OMA" id="AQDMANL"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="80"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="269" mass="30143" checksum="A2D4B5F063B25010" modified="2011-05-03" version="1">MRKKVIVDVRDLFLDVSVNLGFIKKGSLIERIFRFLESKALQKADAVTLVTPKIRHQLVEEYGINPAKCYVVPNGVDLETFKCDKSKRKLQMVYAGYFGHAQDFDTFLKGYALLRENERVPLILAGGGETLEDVLKNVEKLGISKWIKYVGMLSRKDVVKLLCSSSIGVAPIKVDESLKYAIPSKIYEYLACGLPFIGVGVGEIEKIAEESRAGCVGKTPEEVAECIMKLLNSNLEKLKVRALRYVTRFSRESSAKKFLIVLNSLRGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL21</accession>
    <name>F0LL21_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum site-determining MinD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468224.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84928">
        <property type="protein sequence ID" value="ADT84928"/>
        <property type="gene ID" value="TERMP_01953"/>
    </dbReference>
    <dbReference type="GeneID" id="10042269"/>
    <dbReference type="KEGG" id="tba:TERMP_01953"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1952"/>
    <dbReference type="eggNOG" id="arCOG00589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_3_2"/>
    <dbReference type="OMA" id="KLAFHFG"/>
    <dbReference type="OrthoDB" id="51149at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="266" mass="30036" checksum="97C0BAA4CC7741BA" modified="2011-05-03" version="1">MTVVVITGRGGAGKTTLTSNLGVYFARNKYKTLVIDGDLYLPKLGFHFSIDSPRYSIHNLLRDPTLKMENALYRHKKTGVYIIPGSAKLRDIIDVPAFRLKSILHEIMDEFSVIFVDSPTGIPFDTLHIFELADYQIIVIELERSPIYSAEVMIQNEVVKLKSLGDAFGLNVAVVLNKVRESSKNIEAVIDFLEDEIDVPVIGVIPFDHSVPHSVNMGVPILEYKPRSRVSRRLRECGEILEDWMFGKAKVERIIDEIIAEKLLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL44</accession>
    <name>F0LL44_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01977"/>
    <dbReference type="EnsemblBacteria" id="ADT84951">
        <property type="protein sequence ID" value="ADT84951"/>
        <property type="gene ID" value="TERMP_01977"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01977"/>
    <dbReference type="eggNOG" id="arCOG04554">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125807_0_1_2"/>
    <dbReference type="OMA" id="VKVPYST"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029291">
        <property type="entry name" value="Tfx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004645">
        <property type="entry name" value="Tfx_DNA-bd_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018384">
        <property type="entry name" value="Tfx_DNA-bd_euryarc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036657">
        <property type="entry name" value="Tfx_DNA-bd_sf_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14601">
        <property type="entry name" value="TFX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004932">
        <property type="entry name" value="DNA_bind_Tfx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89915">
        <property type="entry name" value="SSF89915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00721">
        <property type="entry name" value="tfx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="154" mass="17771" checksum="A3FC9607F7BAB52F" modified="2011-05-03" version="1">MFKMKSFLTEQQIRILQLRAKGLKQSEIAELLGTSRANVSILEHRALEKIEKARNTLLIWEQINSKISVEVKKGEDIFTIPDKLFKKADELKIKVPYSTAEIIAFLVEHAPIEDRIAKRDFTLFLDAQDKLRVSECLLEDMDKIRKNKGSENSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL74</accession>
    <name>F0LL74_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable tRNA pseudouridine synthase D</fullName>
            <ecNumber evidence="4">5.4.99.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(13) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truD</name>
        <name evidence="6" type="ordered locus">TERMP_00748</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(13) in tRNA = pseudouridine(13) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42540"/>
            <dbReference type="Rhea" id="RHEA-COMP:10105"/>
            <dbReference type="Rhea" id="RHEA-COMP:10106"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.27" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467023.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00748"/>
    <dbReference type="EnsemblBacteria" id="ADT83725">
        <property type="protein sequence ID" value="ADT83725"/>
        <property type="gene ID" value="TERMP_00748"/>
    </dbReference>
    <dbReference type="GeneID" id="10041066"/>
    <dbReference type="KEGG" id="tba:TERMP_00748"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
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    </dbReference>
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    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="162"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="422" mass="48827" checksum="A63617FCF09A82B7" modified="2011-05-03" version="1">MDYKEFFRQFKHLSETPGIGGKIKQRPEDFIVVEIVPKRLISEGHCLIYKLKKKNWETMAAVKEIAKRIGIHYKEIGFAGTKDRHALTVQYISICDTSLKEKLDSLKIQDIKLEFVGYGKALKLGMLIGNKFEIVIREPNLPIEEAFERTKEIIAELKSKGGFPNYFGYQRFGEKRVVNHEIGKLLLKGQFEDAAIKFLGEYTGEMEGDEARKNFLETKNIEKALEEFPKFLRYERAMLYRYKETKSWKKAFAVLPRPILRIFIHSYQSYLFNKVLSRRIEEGLPLNEALVGDIVCQIKHGIPLRSKTFKVTRGTLRLVNEKIKKGEAMVTGPIFGFASRLADGEMGKIEREILEDEGINLKEFKMKSLKILAEPGGRRELLIKPLEFKYKALPEENAMVFKFFLPKGVYATSVLREIMKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL88</accession>
    <name>F0LL88_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00762"/>
    <dbReference type="EnsemblBacteria" id="ADT83739">
        <property type="protein sequence ID" value="ADT83739"/>
        <property type="gene ID" value="TERMP_00762"/>
    </dbReference>
    <dbReference type="GeneID" id="26136214"/>
    <dbReference type="KEGG" id="tba:TERMP_00762"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.764"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072493_0_2_2"/>
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    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF11495">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="3">
        <location>
            <begin position="125"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="264" mass="30726" checksum="2FDAAB6F397F1D1F" modified="2011-05-03" version="1">MAKDRMVELLQEHFELNLYEARAYVALVAFGVLTPAELASVSEVPAPRTYDVLRSLEKKGFAISQPGKVNKYRPVHPKNILEKFIEEWQERVKEELEAKRKAKEELLELMTPLIETEIPKYGVERVWVVRGIRNSTLKTKEMLEGVQKEILLADDGYVAINLEDDIIKAIEKGITVKIVVTKQILPRLQASKLMDYYKNGKFELKVIDTLELPMLICDEEVFFALEDMAARYFNYETQVWIKDFRVVSLFKGKFNEYWEKATKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLA2</accession>
    <name>F0LLA2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT83753">
        <property type="protein sequence ID" value="ADT83753"/>
        <property type="gene ID" value="TERMP_00776"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00776"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.778"/>
    <dbReference type="HOGENOM" id="CLU_3178772_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="46" mass="5114" checksum="ECF8AAA8CAA21232" modified="2011-05-03" version="1">MHNLISAPDGVSLGKVALIVALFLALFILRTLLEKHLEKRSLKKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLA6</accession>
    <name>F0LLA6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00780"/>
    <dbReference type="EnsemblBacteria" id="ADT83757">
        <property type="protein sequence ID" value="ADT83757"/>
        <property type="gene ID" value="TERMP_00780"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00780"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.782"/>
    <dbReference type="eggNOG" id="arCOG15188">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_212438_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="49" mass="5635" checksum="913387288670384C" modified="2011-05-03" version="1">MPRGFGGPMFGRMGWWFGIFGVFLLLFRLAFLLLPFILIGVLIYLIAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLD6</accession>
    <name>F0LLD6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01991"/>
    <dbReference type="EnsemblBacteria" id="ADT84965">
        <property type="protein sequence ID" value="ADT84965"/>
        <property type="gene ID" value="TERMP_01991"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01991"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1988"/>
    <dbReference type="eggNOG" id="arCOG02696">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116585_0_0_2"/>
    <dbReference type="OMA" id="YVFEEMF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009482">
        <property type="entry name" value="DUF1102"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06510">
        <property type="entry name" value="DUF1102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="184" mass="20217" checksum="5E3176B880A39EA9" modified="2011-05-03" version="1">MKMNKVIGLVLLLVGMMLAVGAGANFRYYEAERDLTVAIVGDDNEFIDLTPLQPYVYLNNGKLTVEISDNHPDYPGHGAGMSPNTTYVFEEMFEVSNDLWENYVEDGNVTLTDAYPICVSISVPSNSDVTLFTGDYNGTSSTQLLFTVYHGDPVKIGMVFDNTGAELGENQVQMDIQVFAGECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLE3</accession>
    <name>F0LLE3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468268.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01998"/>
    <dbReference type="EnsemblBacteria" id="ADT84972">
        <property type="protein sequence ID" value="ADT84972"/>
        <property type="gene ID" value="TERMP_01998"/>
    </dbReference>
    <dbReference type="GeneID" id="10042313"/>
    <dbReference type="KEGG" id="tba:TERMP_01998"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1995"/>
    <dbReference type="eggNOG" id="arCOG02258">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1036734_0_0_2"/>
    <dbReference type="OMA" id="WVLGFRD"/>
    <dbReference type="OrthoDB" id="60961at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="2">
        <location>
            <begin position="61"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="267" mass="30945" checksum="ADC835B22A39D034" modified="2011-05-03" version="1">MKKRLPATRVYIRDILEGFFVKSEGDFEPNYLITKDARKVYRAKIVATVVRDPVIAEDETYGKFQVDDGTGVIWVLGFRDDTKFAKLVKKGDLVQIIGKIAEWRGDKQILVEGVSKVHPNMWILHRYETLKDKVEHIKKAKIAFEIYNTYGITAKAKVIAKNKGISEDLLETIDELYAIMIEQRAEEALEEEIFEEEEKKVDETLEEAKKAILEILRSKGDRPVSRKYIERKLQEKFKAEIIDDALRELLAEGEIYEPEIGYYKILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLG9</accession>
    <name>F0LLG9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468294.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02024"/>
    <dbReference type="EnsemblBacteria" id="ADT84998">
        <property type="protein sequence ID" value="ADT84998"/>
        <property type="gene ID" value="TERMP_02024"/>
    </dbReference>
    <dbReference type="GeneID" id="10042339"/>
    <dbReference type="KEGG" id="tba:TERMP_02024"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2021"/>
    <dbReference type="eggNOG" id="arCOG03821">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147804_0_0_2"/>
    <dbReference type="OMA" id="WIVKNST"/>
    <dbReference type="OrthoDB" id="106807at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="143" mass="15791" checksum="BC3E5E1885268EE6" modified="2011-05-03" version="1">MKRGQLSLDLLFAVLLIIVTLTNLTYLATSEISHAESFDTFTKVRLFSSTLVDHSAKVYAIGEGYKVREVAPDLNGGTIRVVFDGATNKIIVNATVNGRSFWIVKNSTVPLSTSSVNLTSGEEFWITAYYNTTEGMLYVKVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLI9</accession>
    <name>F0LLI9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purL</name>
        <name evidence="9" type="ordered locus">TERMP_02044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468314.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02044"/>
    <dbReference type="EnsemblBacteria" id="ADT85018">
        <property type="protein sequence ID" value="ADT85018"/>
        <property type="gene ID" value="TERMP_02044"/>
    </dbReference>
    <dbReference type="GeneID" id="10042359"/>
    <dbReference type="KEGG" id="tba:TERMP_02044"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2041"/>
    <dbReference type="eggNOG" id="arCOG00641">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003100_0_1_2"/>
    <dbReference type="OMA" id="FIEPYQG"/>
    <dbReference type="OrthoDB" id="860at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001587">
        <property type="entry name" value="FGAM_synthase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="8">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="68"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="186"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="417"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="552"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="77"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT85018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="713" mass="78591" checksum="E14936D4553BAF7C" modified="2011-05-03" version="1">MFPHKEKFVREKLGREPNELEWAMIEVMWSEHASYKSSRKWLKLLPTKNEHVILGPGEDAGVVKFDENTAIVVGIESHNHPSAVEPYGGAATGVGGIVRDILCMGARPIALLDPIRFGPLEKERNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDGYTLVNVACIGIMHPNELVHSYVTESGLLLVLVGNKTGRDGIYGVTFASEELSKNAEEEDRSAVQIPDPFTEKLLIEATLEAVKTGKVKALKDLGGGGLTCASSEMAGKKGFGAVIYADKVLQREPNMTAMEVMISESQERMLFAIKKEDLEDMSKIFEKYELEWTVVGEIIDKPRYLVYWGKEKVADLPIDLLTEVPIIEWEAKPYSVERDVQTPEISPQDAFLKVLSSPNILSKEWVYRQYDHEVQGRTVLKPGLDAAVLKINDEYGLAFVSDGNPSYSYLNPYHGAMACVVEAVRNLTSVGAKPLSLVDNLNFASPERPEVYWSFIETVKGLRDAANTFGLAYVSGNVSFYNEVGNKPIKPTPVVAALGKVKLEHITTMDFKDEGELIAIVGVTKKELGGSELYRVLGIEGGIAPRVDLKAEKENVEGILKAIEHGSVKTVHDVSRGGLAIALAEMAIASGLGFEVDISKVPVEAKLSPLEVLFSESQARFIVSFEEENLEKLRKIFKDFAVIGEVKGREMVFKSNEDKVIGVSVKEGRKIYGSLPRLLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLL9</accession>
    <name>F0LLL9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Archaeal histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00819</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467094.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00819"/>
    <dbReference type="EnsemblBacteria" id="ADT83796">
        <property type="protein sequence ID" value="ADT83796"/>
        <property type="gene ID" value="TERMP_00819"/>
    </dbReference>
    <dbReference type="GeneID" id="26136271"/>
    <dbReference type="KEGG" id="tba:TERMP_00819"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.821"/>
    <dbReference type="eggNOG" id="arCOG02144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192667_0_0_2"/>
    <dbReference type="OMA" id="ELPVAPC"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TAF" evidence="5">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="67" mass="7269" checksum="00BD604A320292F0" modified="2011-05-03" version="1">MAELPIAPVDRLIRKAGAQRVSEEAAKLLAEHLEEKAVEIAKKAVDLAKHAGRKTVKAEDIKLAIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLR1</accession>
    <name>F0LLR1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Na(+) H(+) antiporter subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_00861</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467136.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00861"/>
    <dbReference type="EnsemblBacteria" id="ADT83838">
        <property type="protein sequence ID" value="ADT83838"/>
        <property type="gene ID" value="TERMP_00861"/>
    </dbReference>
    <dbReference type="GeneID" id="10041179"/>
    <dbReference type="KEGG" id="tba:TERMP_00861"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.864"/>
    <dbReference type="eggNOG" id="arCOG03079">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069132_3_0_2"/>
    <dbReference type="OMA" id="TAVLFDW"/>
    <dbReference type="OrthoDB" id="117506at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="8">
        <location>
            <begin position="98"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="237" mass="25737" checksum="7BF38944208C6F0E" modified="2011-05-03" version="1">MVKRVLAIILILITGYWLANALAQVPFGADKMLVGKYYLENVKEQTGAVNAVTAVVVNYRGLDTLGEVTVLFIAATGVAALLWRKKRERTAKSEGSVVLQTGSKLLLPFIMLFGAYIFIHGHLTPGGGFPGGATIATAFLMLYLAFREYEIPHNVFEPLEGLAGMGYVAVGLIGLIIGGYFLFDWIWQTWQLGHANIGRLFSAGFIPIIYTLIGLKVGTELTGIVDNMVKEPKEGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLS1</accession>
    <name>F0LLS1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467146.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00871"/>
    <dbReference type="EnsemblBacteria" id="ADT83848">
        <property type="protein sequence ID" value="ADT83848"/>
        <property type="gene ID" value="TERMP_00871"/>
    </dbReference>
    <dbReference type="GeneID" id="10041189"/>
    <dbReference type="KEGG" id="tba:TERMP_00871"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.874"/>
    <dbReference type="eggNOG" id="arCOG01994">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099320_0_1_2"/>
    <dbReference type="OMA" id="IIPHGIV"/>
    <dbReference type="OrthoDB" id="120839at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="186" mass="20242" checksum="FB88CDC9823F4D54" modified="2011-05-03" version="1">MNKKIFLALLGTFLIGVSLGVVFTVLNPQFAENLFLNLKQIFSGKLNGVPDSFTLFKLIFLNNTRVAILAAFGGVLFGVVPLGILFFNGFLVGIVMEYSYLQGESLTKILLSILPHGIVEIPAFAIAGLGGIEWYLEIIKGRGTLGDRFRRGFKTAMKMLGIAIFLLLIAALIEAYVTPSLAGYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLS5</accession>
    <name>F0LLS5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467150.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00875"/>
    <dbReference type="EnsemblBacteria" id="ADT83852">
        <property type="protein sequence ID" value="ADT83852"/>
        <property type="gene ID" value="TERMP_00875"/>
    </dbReference>
    <dbReference type="GeneID" id="10041193"/>
    <dbReference type="KEGG" id="tba:TERMP_00875"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.878"/>
    <dbReference type="eggNOG" id="arCOG04172">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_5_1_2"/>
    <dbReference type="OMA" id="YYGYGGF"/>
    <dbReference type="OrthoDB" id="65776at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="294" mass="32902" checksum="7CB02BF2A2F812A8" modified="2011-05-03" version="1">MRGVIVPLVTPFNEDYSLDFQALEEHIGYLEKVGVHGIFVNATTGEFTSLTKEERKLLAERGRELVNASFYLVGTASTNTFEVVELTKHAEDIGADYAVIAPPYYCPLNDEALFIHYSMIAERTDIPIILYNIPSCANPLSVSLIKKLALEYSNIAGVKETIDSISHVRDVIFEVKGERKDFKVFTGLDHHFLNTLILGGDGGIMACANFAPEIHLKLFKAFEDKKPEMFEYARKLAKLSQVYNLASSFGSAIKIAMQLRGFPVKPVLRPPYVIDGKETREKIKELLSLLELIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLU6</accession>
    <name>F0LLU6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02071"/>
    <dbReference type="EnsemblBacteria" id="ADT85045">
        <property type="protein sequence ID" value="ADT85045"/>
        <property type="gene ID" value="TERMP_02071"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02071"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2068"/>
    <dbReference type="HOGENOM" id="CLU_2911724_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="61" mass="7349" checksum="2AB8E17F9F2C1E56" modified="2011-05-03" version="1">MKTSGRKTPKIYGFIRQLIKLRGDIIKESRIGNLPLWMIFWRREDDHMFFIAIRKKSKPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM01</accession>
    <name>F0LM01_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468396.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02126"/>
    <dbReference type="EnsemblBacteria" id="ADT85100">
        <property type="protein sequence ID" value="ADT85100"/>
        <property type="gene ID" value="TERMP_02126"/>
    </dbReference>
    <dbReference type="GeneID" id="10042441"/>
    <dbReference type="KEGG" id="tba:TERMP_02126"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2123"/>
    <dbReference type="eggNOG" id="arCOG02902">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03264">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG08355">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_243766_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="92"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1614" mass="179936" checksum="11A4AA7C5FE85D7A" modified="2011-05-03" version="1">MKKELQCLLIISLLLMSLGTVPAFQGNYVEAGSENVFITVDSSNFPSEVVLRISLNVSETLSAENFEVYENGVRQQITGVYYTGEGLIMPIDVVFIIDRSDSMDSYIEAIKNSAYQFSYDLERIGGENVRFALVTFANYDDARIDLPLTNNVSEFVEALNSIYTAGGTEWSFGGILKALDLEFNPNAQKVFIVVTDEDDQSPYSVEEVANNLTAEGVLLALVYNHRDGQKLSALSEMIGALDIDISEVQQNGFEEVLHYITTTIGQQYQIVYTPTNQSMDGGERLVKVIINLPDGTYMEANVSYIAKERSIKRYEKVMLTDQEILNILGDIAQWFDESNRYLSMMVDNYQNINLASASYYSMIHREYIPPLPLEEPREFNEFLSKINDLPDSPANTREVENLLMYFTLALNEEGDSLTLKNGTTNVTITLWRVIGFPLVPVVSSEYPIGTPQIRTGEIYKISIQDVLRNSTFYISHSVSKGSPRFQQVEIQDLKIPVEPIEISTLYERVTIYQPMEVDNNAYLVPKIEMEKIIGGVRGKNGAILAAPMSSTVKTLTDYIVEQEYGYKTFKSTSVDPFSSLYIYAGVSGIIEAKVKFLFWRLLGIGGGLDVQFRYYPVRDRMTIRLGSRVGIESIAGEIWLIRGVETASISNASEIGDMVKLWFLYTFTDIPLLDQLAYGELQKTILDAEYSKRSEFLNSTYLFAVVEKSLNFGKLPGQSFVTMSQWDRWSRSPHSKLTVTQVSSIKNNLYRRSFQNYVYKFEEGIKISYPIITVKAEVPLVMAYEIPSVVSAGIFGTVKASAGVSTMLYGYQIVDPVASTSVGTYIMNVSLISESPVDTNSDGLFDGLRLTIEIHSNATGEYNGLFYLLANNTVIVAWPADLSITNSFTLLEILIPSQYLYYTNYTGPFDVGLIIEDENGSIVYSNFSLGRTNSYDYRQFEHVTPQFDFRYVPVDSDKDGKYDEIQVNITELNNLTGITISPILMAPSWMVYLNSTNLTSTSVYTTYIDGMHVRKFMGNFSFMIHVTNKTSGIYLGSYNWSINVDPMKFESAYPTIVDVIPRTINYKPAVTFTVNVSRDSNISIILKYSVGGLVYDTWGYFENVTPGIQNFTVFLDPSAFVLNNTRKATLLSATLITNDLTTDSVKINKEVSFFLLSRADILNIDQNLNAVKKLLNMTIDLISYEDVNSTVVVVLSSGNVTLTNLAYPEMHEKTILELPVTFNLSGILSNVSENGTLSVIMYDENGELLKMKTVNVDLSPLFTPGHLRVYSNPSGASVYINNVYFGTTPLEVDLLPGEYTLELSKEGYQKLIISVTINSGESKTIYATLSPGFLPATLEISSFPSGAKVYIDDELKGLTPLTVEVSPGTHTVKLIRDGYHEYVTTLTIDQGETITINVRLTPLVNYAPFSIGDYTTVVNNASSVFFVFNNYGTPDAFSVSQYVSRTLPIDKRAVSRLAREFDFNEVASNDLIISVGGPLVNNVTARYDNASAVHMSISGGSITIVTPQENITWIVPRPWWNVTEGYFIIQAFYDREFNTTVFTIYGTDADSTAAGAYYFLTEVYPNIAAYNSISYIVGKWEDTEAGADIPLPGANLGDTSGFSAGDTITVIFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM42</accession>
    <name>F0LM42_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Low-affinity inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_00913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential transporter for phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467187.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00913"/>
    <dbReference type="EnsemblBacteria" id="ADT83889">
        <property type="protein sequence ID" value="ADT83889"/>
        <property type="gene ID" value="TERMP_00913"/>
    </dbReference>
    <dbReference type="GeneID" id="26136358"/>
    <dbReference type="KEGG" id="tba:TERMP_00913"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.914"/>
    <dbReference type="eggNOG" id="arCOG02267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_0_1_2"/>
    <dbReference type="OMA" id="RANPHKA"/>
    <dbReference type="OrthoDB" id="40216at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="309" mass="32638" checksum="1E6D631B5E68C7FC" modified="2011-05-03" version="1">MELAIIAAGLFMAWSIGANDSAKAVGIAVGSEILNFKRAVFLIGVFSLLGAFLGSSNVAHTVGSNIVPDFNRNYLSFALLASALAVTFASLKGLPISTTQSIIGAIVGIGIYQKTYVNWGIVLKIALAWVVSPIVSAILSILIFAVYGWIINHISKIYEIEILYRWMIILSSAYASFNLGANELSNVVGLLTYSTNIEVGTLKLILALALFIGALTFSYEVLMTIGKNLTQLGPLAGFSAQFGAALAVTSANIIGLPVSSGQAIIGGIIGLGVLKGHKINKKLAFNIVKGWILAPLVSCLLTLLFIKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM48</accession>
    <name>F0LM48_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00919"/>
    <dbReference type="EnsemblBacteria" id="ADT83895">
        <property type="protein sequence ID" value="ADT83895"/>
        <property type="gene ID" value="TERMP_00919"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00919"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.920"/>
    <dbReference type="HOGENOM" id="CLU_3302927_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="39" mass="4549" checksum="2FDEA6BE85D17EA5" modified="2011-05-03" version="1">MMSALDPDEKMMSGFLADSSFYRTKIYIHVRSNYEMVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM53</accession>
    <name>F0LM53_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467198.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00924"/>
    <dbReference type="EnsemblBacteria" id="ADT83900">
        <property type="protein sequence ID" value="ADT83900"/>
        <property type="gene ID" value="TERMP_00924"/>
    </dbReference>
    <dbReference type="GeneID" id="10041241"/>
    <dbReference type="KEGG" id="tba:TERMP_00924"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.925"/>
    <dbReference type="eggNOG" id="arCOG04590">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117973_0_0_2"/>
    <dbReference type="OrthoDB" id="108170at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="162" mass="18246" checksum="D154A30FF58A0065" modified="2011-05-03" version="1">MDPLKHASIPLLAFLAVSKSPSLVSVAVLLFGAVFPDFDVLFEEHRGYFHSLLFIMPIFTLSFYIQNHYLWLFVFGLGMHFFLDFLSGVIPFLYPLRKKGFGIKVSGVIVFESLPKINVKYEILVGYPARSRGSYVGFSNESLAIALVALIALLFRLKFSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM54</accession>
    <name>F0LM54_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Replication factor C small subunit</fullName>
            <shortName evidence="6">RFC small subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Clamp loader small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rfcS</name>
        <name evidence="8" type="ordered locus">TERMP_00925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the activator 1 small subunits family. RfcS subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467199.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00925"/>
    <dbReference type="EnsemblBacteria" id="ADT83901">
        <property type="protein sequence ID" value="ADT83901"/>
        <property type="gene ID" value="TERMP_00925"/>
    </dbReference>
    <dbReference type="GeneID" id="10041242"/>
    <dbReference type="KEGG" id="tba:TERMP_00925"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.926"/>
    <dbReference type="eggNOG" id="arCOG00469">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_2_1_2"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01509">
        <property type="entry name" value="RfcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023748">
        <property type="entry name" value="Rep_factor-C_ssu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="45"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="326" mass="37220" checksum="342C19DE051337E0" modified="2011-05-03" version="1">MSEEVKEVKILEKPWVEKYRPQRLDDIVGQDHIVKRLKHYVKTGSMPHLLFAGPPGVGKTTAALCLTRELFGEHWRHNFLELNASDERGINVIREKVKEFARTKPIGGASFKIIFLDEADALTQDAQQALRRMMEMFSNNVRFILSCNYSSKIIEPIQSRCAIFRFRPLKDEDIAKRIRFIAENEGLELTEEGLQALLYIAEGDLRRAINVLQAAAALDTKITDENVFLVASRARPEDIREMMLMALEGNFLKAREKLREILLKQGLSGEDVLIQMHKEVFNLPISEPKKVALADKIGEYNFRLVEGANEMIQLEALLAQFTLLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM78</accession>
    <name>F0LM78_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">TERMP_00949</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00949"/>
    <dbReference type="EnsemblBacteria" id="ADT83925">
        <property type="protein sequence ID" value="ADT83925"/>
        <property type="gene ID" value="TERMP_00949"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00949"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.952"/>
    <dbReference type="eggNOG" id="arCOG01181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_1_0_2"/>
    <dbReference type="OMA" id="GYTNFRE"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="108"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT83925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="321" mass="37731" checksum="F940E8818E2C3E2C" modified="2011-05-03" version="1">MNLQTLTGVKMVSKLIALEVYHNLKDIDFRILRGVELNMRHHQWVPLEDIAKFARTDVETASYRLGKLDNWMLVRRRSDIGYIGYQLTIHGYDVLAIRAFARKGVIEAISQTQIGVGKEADVYVGITPQGEKVAVKFNRIGRTSFTRIKLYRRDFIDKHHISWLYISRLVAEREHEALQLLSPIAKVPKPIAWNRHAIVMEFIEGVELSELRDDDLTREEAEDILNKVLDEYLKIVRFGIVHSDMSEFNIVLTEDDDILIIDWPQYLPTAYPESLEYLRRDISVLLNAFHRRWRVKKDFSEVWNEFYEAWLESRGEKDNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM85</accession>
    <name>F0LM85_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">dCMP deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00956</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467230.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00956"/>
    <dbReference type="EnsemblBacteria" id="ADT83932">
        <property type="protein sequence ID" value="ADT83932"/>
        <property type="gene ID" value="TERMP_00956"/>
    </dbReference>
    <dbReference type="GeneID" id="10041273"/>
    <dbReference type="KEGG" id="tba:TERMP_00956"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.959"/>
    <dbReference type="eggNOG" id="arCOG01487">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047993_2_1_2"/>
    <dbReference type="OMA" id="TKWYVLH"/>
    <dbReference type="OrthoDB" id="81620at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="181" mass="20430" checksum="74CD57CF054324E1" modified="2011-05-03" version="1">MKVEIVLDEKKAERIKKIRPTKDEYFMLIAKLVSLRATCPRLRVGAVAVKDGYILATGYNGAPRGMDHCIDVGCLIVDGHCHRAVHAEQNVIAMAARKGISLEGATLYVTHFPCDTCFKLLVNAGIKEIVYEEMYPNKATEILLKEAQEKGMIKIRQFKLPKERVKAFLEELFANEFCDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LME5</accession>
    <name>F0LME5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468464.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02194"/>
    <dbReference type="EnsemblBacteria" id="ADT85168">
        <property type="protein sequence ID" value="ADT85168"/>
        <property type="gene ID" value="TERMP_02194"/>
    </dbReference>
    <dbReference type="GeneID" id="10042509"/>
    <dbReference type="KEGG" id="tba:TERMP_02194"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2189"/>
    <dbReference type="eggNOG" id="arCOG01350">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064691_0_0_2"/>
    <dbReference type="OMA" id="RGNQQFS"/>
    <dbReference type="OrthoDB" id="78237at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039065">
        <property type="entry name" value="AcoX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011386">
        <property type="entry name" value="Put_ATP-NAD_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40697">
        <property type="entry name" value="PTHR40697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016907">
        <property type="entry name" value="Kin_ATP-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="375" mass="41559" checksum="60DCD156809D7AD1" modified="2011-05-03" version="1">MRIGLIINPIAGMGGKVALKGTDGVVEEAIRRGAKPTALDLAKLFLSELSHYDESKNIEFFTGPKELGEYALREFNFSFQVLKHREISYREIFGVRIPDTTSEDTKTLAKLMADKVDILVFAGGDGTARDVYSAVNRKVPILGIPTGVKMFSGVFASSPEDAAKLLIEFLKGSAQIVEREILDLDEDSYRKDEVRVRHYGMALTPYLETLVQGSKEPTAVDESEELEALAEAIVEELEDGVYFLGAGSTVKKIKDKLGIDGTLLGVDIVEIKDGKAKLLVKDAQEKDLLRFINRNPKIIVTIVGGVNFLFGRGNQQFSPDVLRHIPKENIIVVAAPSKVEKPIRAYTGDREVDKKLRGYIRVKIGPWRDRIVKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMG4</accession>
    <name>F0LMG4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-galactosidase/6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_00967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467241.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00967"/>
    <dbReference type="EnsemblBacteria" id="ADT83943">
        <property type="protein sequence ID" value="ADT83943"/>
        <property type="gene ID" value="TERMP_00967"/>
    </dbReference>
    <dbReference type="GeneID" id="10041284"/>
    <dbReference type="KEGG" id="tba:TERMP_00967"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.970"/>
    <dbReference type="eggNOG" id="arCOG06070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_1_1_2"/>
    <dbReference type="OMA" id="NEHASHI"/>
    <dbReference type="OrthoDB" id="24300at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="193"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="435" mass="49497" checksum="9D85283A1F4DD8DA" modified="2011-05-03" version="1">MRIAFIGAGSIFTPLALYTIANSEILSKAEIYLVDIDKERLEFIEAVGRKIGRVFKKELKIWTFQDIRELEDFGIDYAVISVEKERYKRWRLDFEVPHKYGIKQVLGENGGIGGLSHTLRVVPIVLDVAKKIEDINSDARVFIYSNPEPRVTYAVLNYTKLRNAYGLCTGYLERKETLAPLLRVKENQITFIAAGLNHFTWITELYIDGEESYEKLDSALERNPKFEPLSLLLYRAFGLFPSPSDNHIGEYLSFAWDLIPEEKKGLKWIERTKKEGEEVRKLLQLFLKGFVPKFAFNKFIKFPDIAMNIVEGLEGNKKLQEAINVPNKGYIDLPYGTVVEVPAEVSPKGIKPLKVKLTREVIPMLRTQAEIQKLSAEAAAEGNIEKVVQAVLLDPVVNNAESGLKAIAELIEINLDMLPQFSKEDAEEIRKMIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMK4</accession>
    <name>F0LMK4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyruvate-formate lyase-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467281.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01007"/>
    <dbReference type="EnsemblBacteria" id="ADT83983">
        <property type="protein sequence ID" value="ADT83983"/>
        <property type="gene ID" value="TERMP_01007"/>
    </dbReference>
    <dbReference type="GeneID" id="10041324"/>
    <dbReference type="KEGG" id="tba:TERMP_01007"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1010"/>
    <dbReference type="eggNOG" id="arCOG00936">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044176_0_0_2"/>
    <dbReference type="OMA" id="TCVCFFG"/>
    <dbReference type="OrthoDB" id="54365at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="120"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="365" mass="41399" checksum="9B271FCDA79DA3D3" modified="2011-05-03" version="1">MAKCKLCGYESKEISKSIGVCVNCLRKDDQALKTAMESHFKWRELIGLPPEPPKDGELQCKICVNECNIPRGGSGYCGIIWNKGGMLTTITGTFDKAYLHWYLDPHPTNCVAEPICPEREHYGFYNLAVFYAGCNLDCLFCQNVQHKYMIKEGRIDLREGIVLSTDELANIAMQRRVTCVCYFGGDPTPHSIYALKVSRKILKQAEESKEMKRICWETNGLENPKIMTKMAELSLKSGGIVKIDWKAYTSSVYQALTGINGEKAIKRIKENIKLVLKMSEGRELPLLVVSTLVVPHYIDEHEVFNIARYIAGINPETPYVLLAFTPQHLMYDVPTTSRRQMEKVYKAAQEAGLKNIYIGNPWLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMP6</accession>
    <name>F0LMP6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467323.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01049"/>
    <dbReference type="EnsemblBacteria" id="ADT84025">
        <property type="protein sequence ID" value="ADT84025"/>
        <property type="gene ID" value="TERMP_01049"/>
    </dbReference>
    <dbReference type="GeneID" id="10041366"/>
    <dbReference type="KEGG" id="tba:TERMP_01049"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1052"/>
    <dbReference type="eggNOG" id="arCOG10341">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078140_0_0_2"/>
    <dbReference type="OrthoDB" id="120668at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="309" mass="34859" checksum="7C1AA1C60ACC38F5" modified="2011-05-03" version="1">MKFIFGGKKKEEKKSSIDPELRRIVGRIMSSHGEGLYQLLVRASPDGDVEKIKKMLAHNEAYNAPEVTTKSKYRKMYVETKDLQHKIAAAHYPILHTFLALAYHTGSHSPLTASVVGDILTAAYQTKADYSELKKRKETLARAIAKRAKERGITTDEDKTAKVVETALDKAFKIIDKIAPDHKKENLAILTRAISASTDDPFVVLRNAGIDIEPELEEFRQFLAEISGKKIEEKPKLQIIPPEVLAIVKGLKFADYSDSALKRAEEELLSKIDSLLDSYPKTARLIGHYAALLRLIQRKDFEKLEELFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMR3</accession>
    <name>F0LMR3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative asparagine synthetase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="3">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O + L-aspartate + L-glutamine = AMP + diphosphate + H(+) + L-asparagine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467340.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01066"/>
    <dbReference type="EnsemblBacteria" id="ADT84042">
        <property type="protein sequence ID" value="ADT84042"/>
        <property type="gene ID" value="TERMP_01066"/>
    </dbReference>
    <dbReference type="GeneID" id="10041383"/>
    <dbReference type="KEGG" id="tba:TERMP_01066"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1069"/>
    <dbReference type="eggNOG" id="arCOG00093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_4_0_2"/>
    <dbReference type="OMA" id="DWSGIYS"/>
    <dbReference type="OrthoDB" id="12911at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="5">
        <location>
            <begin position="2"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="346"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="480" mass="54347" checksum="B53FD5C77692062E" modified="2011-05-03" version="1">MCLIAGGVGKSLKERIVKMIFAGKHRGEDSFGVWTDEGVLKSRNFSKVYEIPNGNIALLQCRLAMTGSKEFTQPFYNEFVLVHNGEIYNHTQIREYLENKGISFESNVDSEVILRLLEFLIHEKDMSYVTAVKKSMKILNGDYAVAFSDGREIYLFRDPIGIRPLYYSPNGFFASEKKVLWSIDENAIPVNPGEVVKISKGKVERFKVFNILELRDSFFPYERAKKSLIKSLEYSVKIRVGKKTGVLFSGGLDSSLLALLSSKYSNVTLYAAGAEGSQDLEWARKVGDMLGLKLKEYVFDISDVEEVIPKVVFAIEEPNPMNLAIGIPLYFATKLAKEDNRKLLLSGQGADELFGGYFKYLENPGLMEKDLIELGEKNLARDDKIAMLNSVEGRFPFLDLNVVRTALRTPIGFKIKNGIRKAILREVAFELGLPKEVAYREKKACQYGTNSQKILQKIAKNKGMKTKEFVHRVFNEVFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMS5</accession>
    <name>F0LMS5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01078"/>
    <dbReference type="EnsemblBacteria" id="ADT84054">
        <property type="protein sequence ID" value="ADT84054"/>
        <property type="gene ID" value="TERMP_01078"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01078"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1081"/>
    <dbReference type="eggNOG" id="arCOG02491">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_965120_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="288" mass="31970" checksum="ACDF153FF2C9EAF9" modified="2011-05-03" version="1">MLFDKNGNLLWKFNAMTKVKRVAISEDGSIVAASSYDGNLYVFSREGLKWKRYLEDKLAGVSISKDNQLIAVGGFSGYVYILSLNGEILGAYLTKMPVFAVDFDKTYVVAGDYNGTVVYLSPNGTLIWKIQLRGSIWDLETFGGKILVGTANGDFSLLSNNGNILWEEHLGNTTKIGVFDVSIFKRYLVGVAVDTENGGGGIYLVDENETILWKFEKADEYFLSVDSNNNQIIVGTSIWDNKRKAWNKSKIYAFGIVENKTKKKTCGVGFILIGVLVAIVLTKKLMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMT5</accession>
    <name>F0LMT5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GimC subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pfdA</name>
        <name evidence="7" type="ordered locus">TERMP_01088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the prefoldin alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467362.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01088"/>
    <dbReference type="EnsemblBacteria" id="ADT84064">
        <property type="protein sequence ID" value="ADT84064"/>
        <property type="gene ID" value="TERMP_01088"/>
    </dbReference>
    <dbReference type="GeneID" id="10041405"/>
    <dbReference type="KEGG" id="tba:TERMP_01088"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1091"/>
    <dbReference type="eggNOG" id="arCOG01341">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091867_1_3_2"/>
    <dbReference type="OMA" id="ELQNQFM"/>
    <dbReference type="OrthoDB" id="111673at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00308">
        <property type="entry name" value="PfdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PTHR12674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00293">
        <property type="entry name" value="TIGR00293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="97"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="148" mass="16789" checksum="023D2159BAF598ED" modified="2011-05-03" version="1">MAQNQEQLERLAYEYQLLQAQAQLLAQNLELLTLGMNEFRAVKETLEELKKVEEEKPEILVPVGAGSFLKGMIVDKEHAIISVGSGYAVEKSLEDAVAYLDARIKEYEDAIKRTQEALQQIQEKLQDLAQKAQKIQQEQAMGFKVPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMY5</accession>
    <name>F0LMY5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Deblocking aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_01138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467412.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01138"/>
    <dbReference type="MEROPS" id="M42.004"/>
    <dbReference type="EnsemblBacteria" id="ADT84114">
        <property type="protein sequence ID" value="ADT84114"/>
        <property type="gene ID" value="TERMP_01138"/>
    </dbReference>
    <dbReference type="GeneID" id="10041455"/>
    <dbReference type="KEGG" id="tba:TERMP_01138"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1141"/>
    <dbReference type="eggNOG" id="arCOG01518">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_1_0_2"/>
    <dbReference type="OMA" id="FGWPAIH"/>
    <dbReference type="OrthoDB" id="27966at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="348" mass="38431" checksum="10C79C75C97238BF" modified="2011-05-03" version="1">MVDYELLKKIVEAPGVSGYEFLGVRDVVIEAFKDHVDEIKVDKLGNVIAHKKGDGPKVMLAAHMDQIGLMVTHIEKNGFLRVAPIGGVDPRTLIAQRFKVWIGKDKFIYGVGGSVPPHIQKPEDRKKAPDWDQVFIDIGAESKEEAEEMGVRIGTIITWDGRLERLGKHRLVSIAFDDRIAVYTLVETARKLSETNADIYFVATVQEEVGLRGARTSAFGIDPDYGFAIDVTIAADVPGTPEHKQVTQLGKGTAIKIMDRSVICHPTIVRWMEELAKKYEIPYQWDILLGGGTDAGAIHLNKAGVPTGAVSVPSRYIHSNAEVVDERDVDAGVELMVKVLEHIHELKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMZ4</accession>
    <name>F0LMZ4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase-4 component H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467421.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01147"/>
    <dbReference type="EnsemblBacteria" id="ADT84123">
        <property type="protein sequence ID" value="ADT84123"/>
        <property type="gene ID" value="TERMP_01147"/>
    </dbReference>
    <dbReference type="GeneID" id="10041464"/>
    <dbReference type="KEGG" id="tba:TERMP_01147"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1150"/>
    <dbReference type="eggNOG" id="arCOG01543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_3_1_2"/>
    <dbReference type="OMA" id="AEHHRES"/>
    <dbReference type="OrthoDB" id="108931at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="172" mass="19525" checksum="222E835BB9217B59" modified="2011-05-03" version="1">MGRFKLIAKAVSIGKVTEKYPFVPIEVPEGFRGKPVIDPEKCIGCTSCSNACPPQALQVYDEPERGVRVVHLFIGRCIFCARCQDVCPTGAIKLTKEFELATLSEEDLHQFVELKMVRCEECGRPFDTFRHLLYSAKELQPWEREMMFLCPECRAKKVSERLIFAKGGGEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN34</accession>
    <name>F0LN34_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467461.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01187"/>
    <dbReference type="EnsemblBacteria" id="ADT84163">
        <property type="protein sequence ID" value="ADT84163"/>
        <property type="gene ID" value="TERMP_01187"/>
    </dbReference>
    <dbReference type="GeneID" id="10041504"/>
    <dbReference type="KEGG" id="tba:TERMP_01187"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1190"/>
    <dbReference type="eggNOG" id="arCOG01144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_377511_0_0_2"/>
    <dbReference type="OMA" id="IVLIHHP"/>
    <dbReference type="OrthoDB" id="30489at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027552">
        <property type="entry name" value="CGP_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04288">
        <property type="entry name" value="CGP_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="125"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="658" mass="72387" checksum="DDAE47CF813274BF" modified="2011-05-03" version="1">MRKGIALLLVLMVFSMFQAVQVEAATLYPLDVLQYPAPGAPAVAIPGDTITVKAQPGVEITGLSIVSILHGPYELQIVEKNGDELKVKIPENVAPDDYFLIVQSNKGKVIVPNGVWVLKEYPKVLRIAHGSDLHVTSGAKIGYVNGEKFCRSIFKCGEGAIPLHSYVADDSFFTYWGMNPNVDVIIATGDVVDTAGDSKAYGYLLGLMENAIAAGKPTIIVKGNHDDPPKYFSKMIAPPTYYLTIGKFIIIALDSDNERSHPTMEQLEWMEKILEQNPDKIPIIIVHHPYWYKTPEGRSGKIEGMSVFEDWDKIAPLVSWYWIGGKERKTEDIAKRFLEDVEKYNIKLVLSGHVHADYVQVYVDKKGNEHWFVTSTTTGAPDKREKDNWYGSRIVEIDENGNVRLPGIKDMFGTIFGPISSFPIPQEFIVFRHTTDFGSAIKFVNEFKEASGKLAVVVPNGAKVDAGATTVKYKVLGERTIGDKHYMLLEVTVPKGVSQLVITKGKDTEKPQVSIAYTSPAKPVKGKPFKVYFKASDNLGIKDLYVEIEANGEVKKYPAEPTKGGPNVDYFLAQIPGVNADEYTIRVVAIDFYGNKAVAEKVMGKPTPTSTTKTTTTTTSQTSSESSPTTQTATQASTCGPAVLVGLALIPLLLRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN36</accession>
    <name>F0LN36_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putrescine transport ATP-binding PotA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_01189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467463.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01189"/>
    <dbReference type="EnsemblBacteria" id="ADT84165">
        <property type="protein sequence ID" value="ADT84165"/>
        <property type="gene ID" value="TERMP_01189"/>
    </dbReference>
    <dbReference type="GeneID" id="26136651"/>
    <dbReference type="KEGG" id="tba:TERMP_01189"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1192"/>
    <dbReference type="eggNOG" id="arCOG00177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OMA" id="HLGWEIQ"/>
    <dbReference type="OrthoDB" id="88924at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015417">
        <property type="term" value="F:ABC-type polyamine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT84165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="353" mass="40043" checksum="4763289B23CF3E9A" modified="2011-05-03" version="1">MVEVKLENIVKTFGETVALKGIDLHIKHGELFTLLGPSGCGKSTTLRIIAGLDFPDKGRIFFDDQEVTYLSSSERGAVLVFQNYALWPHMTVYDNIAYGLKIKKLPKDEIEKKVRWALQLVKLEGFEDRYPTQLSGGQQQRVAIARAIVVEPKLLLLDEPLSNLDAKLRLEMRSEIRRIQRELGITVLYVTHDQEEAMAISDRIAVMNVGTVEQVGTPREIYEKPKTEFVASFMGKTNVIPAKVVEREGDKVTVEFEHFRLEGVTYTDKSDKVVIVIRPERISLKPIENAVKLEGKVDLIEYYGFFIEVVGMFGETRIIARTISDKDVMSLKPQGPVTFYINKDDILVLPKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN51</accession>
    <name>F0LN51_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_02217</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
            <plasmid evidence="6 7">pTBMP1</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747412.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02217"/>
    <dbReference type="EnsemblBacteria" id="ADT85190">
        <property type="protein sequence ID" value="ADT85190"/>
        <property type="gene ID" value="TERMP_02217"/>
    </dbReference>
    <dbReference type="GeneID" id="10549041"/>
    <dbReference type="KEGG" id="tba:TERMP_02217"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2211"/>
    <dbReference type="eggNOG" id="arCOG00467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025112_3_1_2"/>
    <dbReference type="OMA" id="DQYNTET"/>
    <dbReference type="OrthoDB" id="93705at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="56"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="5">
        <location>
            <begin position="306"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="68"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT85190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="404" mass="46231" checksum="CA4E655AF06BE9D9" modified="2011-05-03" version="1">MSDKLKEIFTKRRTTTRILLYPQYLSEGYIPEKLLFRDREVEEIAGHAADFLFSSIVKNLVIHGPPGVGKTVAVRMLERTYNEVALENEIDSRAIYISAKDLTYRRVLYELASQLGINVNLGMSIADIYDSTIMYMKEKESKYLIIVDEIDKLRKRPGEEPVDNLVYSLSRINERVGKVVVSIFFVTNNARIVERLSAPSFSSLSPIFVYFRNYNTDELYAILKDRVEKAFAPGTVDDAALRLLAALIRRESRDLRWAFLVLREAPNEAENGKITEKSIWRAVEIIERKVLNQVINGLDIDALLLLYALAVLTEKGHAQIDSSTLYLKYKELCDVLGWYPRTMKHTINYIGAKLEAEGLITRKAISRGRYGRTHLFHLEEDPTTVKNITKEIIAGRFNLSATQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN70</accession>
    <name>F0LN70_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747431.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02236"/>
    <dbReference type="EnsemblBacteria" id="ADT85209">
        <property type="protein sequence ID" value="ADT85209"/>
        <property type="gene ID" value="TERMP_02236"/>
    </dbReference>
    <dbReference type="GeneID" id="10549060"/>
    <dbReference type="KEGG" id="tba:TERMP_02236"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2230"/>
    <dbReference type="eggNOG" id="arCOG04448">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024566_8_2_2"/>
    <dbReference type="OMA" id="PGTWTDD"/>
    <dbReference type="OrthoDB" id="74062at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="313" mass="35173" checksum="0DA7DD4311714105" modified="2011-05-03" version="1">MLRSRLEGGLWGVLVGDAFGLTFQFTSRLAMELNYPKPKEIPMLDGLWSDDSSLTLATAHALREGYSIERIAENFLRWYYDGEFTPRGYTFDQGNTTSRAIERIANGVPPLEAGGRGEWDNGNGSLMRIPPAAYYAYFKLNSLEERLKLIHEVSMITHAHPRALIGCGIYSLIVWNILDGMDKLKAYHKAIETAEKFYLRESFAKELAHYERVLSGRIHKVERSEIRGSGYVVHTLEASFWAFLRNESFVNAIKEVISLGEDADTTGAVTGGLAGTYYGIGAIPQEWLEKIEAKEYAGEIINTFIDSLLGRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LNA2</accession>
    <name>F0LNA2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
            <plasmid evidence="3 4">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747463.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02268"/>
    <dbReference type="EnsemblBacteria" id="ADT85241">
        <property type="protein sequence ID" value="ADT85241"/>
        <property type="gene ID" value="TERMP_02268"/>
    </dbReference>
    <dbReference type="GeneID" id="10549092"/>
    <dbReference type="KEGG" id="tba:TERMP_02268"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2262"/>
    <dbReference type="eggNOG" id="arCOG06149">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055960_0_0_2"/>
    <dbReference type="OMA" id="YANAFAY"/>
    <dbReference type="OrthoDB" id="52760at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="114"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="334" mass="38821" checksum="198AFE5E644A7B07" modified="2011-05-03" version="1">MKRSLKLTIVLGVKHGLLVSLVWIFLLNLIPAIYDAIWGEKIINDVVSTVIGNETNPNKIALNIYFWEKSNFVSPYTYYQKTPELLRNIGIYKIEGEYRWFLRPTFYPTPVSWILHSKLANCEEYARVFVFIMTHAGVKARIVRAPGEDHAWAEYYYNGIKIVFDPSTVGPIVDPKKFAEGRHWSYVESVDMFNPADRIDVSDEYIKRGKLIVKISKRNTPVKGATVVVYSTYLMKRYPDRYRSPRKVLEQISDENGMATFLLGENEYLLKIKKCYMGFLCLITERKAYVKVDDTSIVDVDFSTARLSNGTIFLMLIGIFGMLIIFWKKRRRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGU2</accession>
    <name>F0LGU2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5 13">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">TERMP_00003</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the archaeal-type GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="5 13"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466279.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00003"/>
    <dbReference type="EnsemblBacteria" id="ADT82981">
        <property type="protein sequence ID" value="ADT82981"/>
        <property type="gene ID" value="TERMP_00003"/>
    </dbReference>
    <dbReference type="GeneID" id="26137853"/>
    <dbReference type="KEGG" id="tba:TERMP_00003"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.3"/>
    <dbReference type="eggNOG" id="arCOG02602">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105797_0_0_2"/>
    <dbReference type="OMA" id="YPADAGH"/>
    <dbReference type="OrthoDB" id="72912at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016758">
        <property type="entry name" value="G6P_isomerase_archaea/bacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010551">
        <property type="entry name" value="G6P_isomerase_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06560">
        <property type="entry name" value="GPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019325">
        <property type="entry name" value="Glucose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPI" evidence="14">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR019325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADT82981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="189" mass="21570" checksum="C1306BEFB7E4E13E" modified="2011-05-03" version="1">MYKEPFGVKLDFETGIIENAKKLVRKLSDMKGYFLDEQAWKELVEKEDPVVYEVYAIEQEEKDGDLNFATTVLYPGKVGKEFFFTKGHYHAKADRAEIYFALKGRGGMLLQTPEGKAKFIEMVPGTVVYVPPYWAHRTVNTGNEPFIFLAVYPADAGHDYGTIKEKGFSKIVVEEDGKVVVKDNPKWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH36</accession>
    <name>F0LH36_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467542.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01268"/>
    <dbReference type="EnsemblBacteria" id="ADT84244">
        <property type="protein sequence ID" value="ADT84244"/>
        <property type="gene ID" value="TERMP_01268"/>
    </dbReference>
    <dbReference type="GeneID" id="26136751"/>
    <dbReference type="KEGG" id="tba:TERMP_01268"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1271"/>
    <dbReference type="eggNOG" id="arCOG05722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2766259_0_0_2"/>
    <dbReference type="OMA" id="IDDINWI"/>
    <dbReference type="OrthoDB" id="120302at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="70" mass="7999" checksum="A36F394560D4E487" modified="2011-05-03" version="1">MSEPLLDETLKKWKDRKIALAVNGEHSFIGILREFDGESLLLEDVTDVVGNKGKQLLVRIDDVSWIMLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH43</accession>
    <name>F0LH43_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01276</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467549.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01276"/>
    <dbReference type="EnsemblBacteria" id="ADT84251">
        <property type="protein sequence ID" value="ADT84251"/>
        <property type="gene ID" value="TERMP_01276"/>
    </dbReference>
    <dbReference type="GeneID" id="10041592"/>
    <dbReference type="KEGG" id="tba:TERMP_01276"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1278"/>
    <dbReference type="eggNOG" id="arCOG01832">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_12_0_2"/>
    <dbReference type="OMA" id="WREPFVD"/>
    <dbReference type="OrthoDB" id="100198at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="52"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="57"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="167" mass="20369" checksum="9CE75C27D67AEB13" modified="2011-05-03" version="1">MVRRVRRWDIWDPFDIMREIQEEIDSIFNEFFRGPRLWSYRRWSEPEYFEERIEGVWREPFVDIFDNGNEFIITAELPGVRKEDIKVRVTDDTVYIEAQVRREKELEREGAIRVERYYSGYRRVIRLPEEVIPEKAKAKYNNGVLEIRIPKKHPTKKEGEGFEVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH75</accession>
    <name>F0LH75_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466335.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00059"/>
    <dbReference type="EnsemblBacteria" id="ADT83037">
        <property type="protein sequence ID" value="ADT83037"/>
        <property type="gene ID" value="TERMP_00059"/>
    </dbReference>
    <dbReference type="GeneID" id="10040378"/>
    <dbReference type="KEGG" id="tba:TERMP_00059"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.59"/>
    <dbReference type="eggNOG" id="arCOG02491">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846277_0_0_2"/>
    <dbReference type="OrthoDB" id="20532at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="328" mass="37298" checksum="40E76AA22B6E3E14" modified="2011-05-03" version="1">MKRMLFFFLFILLFQESFVYSWITLVPVSPLSQSIYYAPRDVTIFSVSNDSRHVAVGFNAICIYINNPEGGTYERCDGSASIYLLKDGELLWKKENIGDFIVSLSLSSNYVAVAVQKAQKIGVGFIYLFDRKGNLIWRKETEWPQRIIITTKNNIILGTQDDYVYAFDKEGNLLWKKRAGGILDISVDGNYIVAGSTNTKTIYLLDRNGTILWRREVGLLGNAAISEKGEYVATIVFDNYNDYYNSKNGKVLIFNKAGKLLHEYKNVSTFSLSKEGKYLALAFRDNIVLLDIEGGIMWERSIKNGMLISLNNDLMQLVPPMVNYISHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHA0</accession>
    <name>F0LHA0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466360.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="SMR" id="F0LHA0"/>
    <dbReference type="STRING" id="391623.TERMP_00084"/>
    <dbReference type="EnsemblBacteria" id="ADT83062">
        <property type="protein sequence ID" value="ADT83062"/>
        <property type="gene ID" value="TERMP_00084"/>
    </dbReference>
    <dbReference type="GeneID" id="10040403"/>
    <dbReference type="KEGG" id="tba:TERMP_00084"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.84"/>
    <dbReference type="eggNOG" id="arCOG00600">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076812_1_0_2"/>
    <dbReference type="OMA" id="DEWTWES"/>
    <dbReference type="OrthoDB" id="67420at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="67"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="133"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="228"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="282" mass="31865" checksum="3235782A1632E0A7" modified="2011-05-03" version="1">MKVKSIMTPDPVVIELPATRGYALELFKKHKVRSFPVVRRGNKELVGIVSIKRVLVNPDEDQLAMLVKRDVPVVKPTDDLKKAVRLMLDYDYRRVIVVNDDGKVVGILTVGDIIRRYLAKNEKYRNVEIEPYYQRNVSVVWKGTPLKAALKALLLCNAMAIPVIDDDGNLVGIVDETDLLKDSEVVRVMKSSALAVSSEEEWILESNPILLFEKAELQLPKKPVEDIMTKNPIIATPHMSVYDVANKMAKYKIEQLPVIKGEGDLVGLIRDMDLIKVIVNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHA4</accession>
    <name>F0LHA4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466364.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00088"/>
    <dbReference type="EnsemblBacteria" id="ADT83066">
        <property type="protein sequence ID" value="ADT83066"/>
        <property type="gene ID" value="TERMP_00088"/>
    </dbReference>
    <dbReference type="GeneID" id="26135404"/>
    <dbReference type="KEGG" id="tba:TERMP_00088"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.88"/>
    <dbReference type="eggNOG" id="arCOG02263">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1891542_0_0_2"/>
    <dbReference type="OMA" id="WDIAKLC"/>
    <dbReference type="OrthoDB" id="117737at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012426">
        <property type="entry name" value="SepF_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019313">
        <property type="entry name" value="UCP019313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="133" mass="15202" checksum="A58F3443AE84CCB9" modified="2011-05-03" version="1">MGLFDKIIKKEEPKRKPLKFSRKELEGKVRADIDVIPMEEDELAKEIAKPEIRYIKKIVVTSYTDLEKISEEIQEGNIVIVDLTPLESKQEILEKIAEQIKGMVHGLGGDLAKVSKYEIKLIVTPPDIKIYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHB2</accession>
    <name>F0LHB2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl22</name>
        <name evidence="7" type="ordered locus">TERMP_00096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="4 6">This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466372.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00096"/>
    <dbReference type="EnsemblBacteria" id="ADT83074">
        <property type="protein sequence ID" value="ADT83074"/>
        <property type="gene ID" value="TERMP_00096"/>
    </dbReference>
    <dbReference type="GeneID" id="26135412"/>
    <dbReference type="KEGG" id="tba:TERMP_00096"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.97"/>
    <dbReference type="eggNOG" id="arCOG04098">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_0_2_2"/>
    <dbReference type="OMA" id="ANAEYKG"/>
    <dbReference type="OrthoDB" id="103467at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_A">
        <property type="entry name" value="Ribosomal_L22_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_L22/L17_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="PTHR11593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="156" mass="17785" checksum="132CFA577EDC930C" modified="2011-05-03" version="1">MSRGRFGYSFQNFDPERMARASGRDLRISPKFSVEICREIRGMMLNDAIKFLDDVIAMRRPVPLRRFNDSQGHKRGKGFGPGRYPVKVAKAIKKVLLNAKNNAEQKGLDPDKLKIIHAAAHRGPVLRGYIPRAFGRATPFNEETTHIEIVVEEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHC1</accession>
    <name>F0LHC1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl5</name>
        <name evidence="8" type="ordered locus">TERMP_00105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466381.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00105"/>
    <dbReference type="EnsemblBacteria" id="ADT83083">
        <property type="protein sequence ID" value="ADT83083"/>
        <property type="gene ID" value="TERMP_00105"/>
    </dbReference>
    <dbReference type="GeneID" id="10040424"/>
    <dbReference type="KEGG" id="tba:TERMP_00105"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.106"/>
    <dbReference type="eggNOG" id="arCOG04092">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_2"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="OrthoDB" id="97230at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_A">
        <property type="entry name" value="Ribosomal_L5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022804">
        <property type="entry name" value="Ribosomal_L5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="6">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="7">
        <location>
            <begin position="72"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="183" mass="20806" checksum="179E89B4B1D16AA6" modified="2011-05-03" version="1">MIANREAILADWEAHPMRRPRIAKVTINIGVGGSGERLTKAETMLQQLVGQKPIRRRAKKTNRDFGIRRGEPIAVKVTLRGKKAYEMLKRLLAAVDNKLKASSFDEHGNVCFGIDEHINIPGVEYDPEIGIFGMDVCVTLERPGFRVARRRRKRTKIPTRHKLTKEEGMVFMQEEFGVEIVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHD6</accession>
    <name>F0LHD6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD synthase</fullName>
            <ecNumber evidence="3">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">FMN adenylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Flavin adenine dinucleotide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ribL</name>
        <name evidence="5" type="ordered locus">TERMP_01288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal FAD synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467561.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01288"/>
    <dbReference type="EnsemblBacteria" id="ADT84263">
        <property type="protein sequence ID" value="ADT84263"/>
        <property type="gene ID" value="TERMP_01288"/>
    </dbReference>
    <dbReference type="GeneID" id="10041604"/>
    <dbReference type="KEGG" id="tba:TERMP_01288"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1290"/>
    <dbReference type="eggNOG" id="arCOG01222">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_2_1_2"/>
    <dbReference type="OMA" id="FAKKHAD"/>
    <dbReference type="OrthoDB" id="79845at2157"/>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046444">
        <property type="term" value="P:FMN metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02115">
        <property type="entry name" value="FAD_synth_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024902">
        <property type="entry name" value="FAD_synth_RibL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 3" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="12"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="16"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="21"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="150" mass="17191" checksum="5DA13558E2BFCF18" modified="2011-05-03" version="1">MSKEREKKIRVLVGGVFDILHVGHIHFLSQAKQLGDELVVIVAHDETVVRRKGRPPINSMHERAEVLKALKMVDEVYIGEPDGISFELVKRINPDVVALGPDQDFKCEELKRQLRQHGINAEVIRIPYLYKSDVAKTSRIIKRIVEIFCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHE0</accession>
    <name>F0LHE0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467565.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01292"/>
    <dbReference type="EnsemblBacteria" id="ADT84267">
        <property type="protein sequence ID" value="ADT84267"/>
        <property type="gene ID" value="TERMP_01292"/>
    </dbReference>
    <dbReference type="GeneID" id="10041608"/>
    <dbReference type="KEGG" id="tba:TERMP_01292"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1294"/>
    <dbReference type="eggNOG" id="arCOG04232">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_5_1_2"/>
    <dbReference type="OMA" id="PWGGSAY"/>
    <dbReference type="OrthoDB" id="8357at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="2">
        <location>
            <begin position="39"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="491"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="562" mass="64349" checksum="6FD18341A25E7A7E" modified="2011-05-03" version="1">MTFDRKKLDEIRKAEQEWEENVVKPLIAKRPERKEKFMTDDGFEIKRVYTPADLGEDWDYMEKLGFPGQYPFTRGVYATMYRGRFWTMRQYAGYATAEESNKRYKYLLEQGQTGLSVAFDLPTQLGYDSDHPMAEGEVGKVGVAIDSLWDMEILFDGIPLDKVSTSMTINSTAANLLAMYILVAEKQGVPQHVLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFNAHNNFLEEIAKFRAARRLWAKIMKEKFGAKNPKSMLLRFHTQTAGSTLTAQQPENNIIRVTIQALAAVLGGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTIDPLGGAYYIEWLTDHIEEEAMKYIEKIERMGGMMRAIERGYIQKEIADSAYKYQKEVEEGKRIIVGVNKFVVDEPIEVEILKVDPSIRDKQIERLRKLRSERDNKKVEEALDKLRNAAEKEDVNLMPYIIEAHRHLATLGEVTDVLREVWGEYRAPLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHF0</accession>
    <name>F0LHF0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">flpA</name>
        <name evidence="5" type="ordered locus">TERMP_01302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467575.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01302"/>
    <dbReference type="EnsemblBacteria" id="ADT84277">
        <property type="protein sequence ID" value="ADT84277"/>
        <property type="gene ID" value="TERMP_01302"/>
    </dbReference>
    <dbReference type="GeneID" id="26136781"/>
    <dbReference type="KEGG" id="tba:TERMP_01302"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1303"/>
    <dbReference type="eggNOG" id="arCOG00078">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059055_2_0_2"/>
    <dbReference type="OMA" id="INMATHR"/>
    <dbReference type="OrthoDB" id="58340at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="226" mass="25679" checksum="D9B22FA1AE5DE672" modified="2011-05-03" version="1">MKIKKHKFPGVYVFIDEDGSEKIATKNLVPGQKVYGERIVKWEGEEYRIWNPRRSKLAAAIMNGLKNFPIKPGVSVLYLGIASGTTASHVSDIVGWEGKIFGIEFSPRVLRELVPIVEERRNIIPILGDATKPEEYRALVTKVDVIFEDVAQPTQAKILIDNAKAYLKSRGYGMIAVKSRSIDVTKEPEEVFKMVEEELGEYFEIVERISLEPYEKDHALFVVRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHG6</accession>
    <name>F0LHG6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterial autolysin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01318"/>
    <dbReference type="EnsemblBacteria" id="ADT84293">
        <property type="protein sequence ID" value="ADT84293"/>
        <property type="gene ID" value="TERMP_01318"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01318"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1319"/>
    <dbReference type="eggNOG" id="arCOG00395">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_830601_0_0_2"/>
    <dbReference type="OMA" id="LIIVRND"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="273"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="337" mass="37690" checksum="302AEA407D93C089" modified="2011-05-03" version="1">MKNKVWISLSLLILLAVSLVSFTLLPVNAQENKQQYDLIIVRNDDLIDYIVALPYSKLINAPILPVDPQMLDDKTKAQLYSYAQLGWRKILIVGNSNAISKEVEDELLSLGFSVTRIGGAVRTETAEKLAVAFYPEGSNTVVLASAMDYGSALAAAKFAMEYQLPLLLTLENDLSEFTIMGLKKLHPRLVIMIGTGLNETIEKRLQEMGYETYWLGHQIGPPPVSKPEKESPIPWVVIGAVLSLAIAVPIILYWAKKKWAANRVPIEVLTEKERIVVKAILEKGGKVKQEDLPELTGYSRPTVSRIVQELEKKQLVTREKIGKTFIVKLIKEINLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHI6</accession>
    <name>F0LHI6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467611.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01338"/>
    <dbReference type="EnsemblBacteria" id="ADT84313">
        <property type="protein sequence ID" value="ADT84313"/>
        <property type="gene ID" value="TERMP_01338"/>
    </dbReference>
    <dbReference type="GeneID" id="10041654"/>
    <dbReference type="KEGG" id="tba:TERMP_01338"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1338"/>
    <dbReference type="eggNOG" id="arCOG01403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_1_2"/>
    <dbReference type="OMA" id="FFCPNAG"/>
    <dbReference type="OrthoDB" id="83551at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="189"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="378" mass="42615" checksum="F0C092506B7AF7D7" modified="2011-05-03" version="1">MRIALVSDWYYPKIGGVASHMHHLALKLREMGHEVAIITNNRETGKETELEEKGIRLIKIPGVVSPILEVNITYSLKSTRELNEFLKEFDVVHSHHAFTPLALKAAKAGREMGKATLLTTHSISFAHESKLWEALGLTFPMFSNYLKYPHKIIAVSKAAKAFIEHFTDTPIEIIPNGVDDKLFTPKWDKERIKAEFGIDNKVVLYVSRMSYRKGPHVLLNAFSEIEDATLVMVGSGEMLPFLRAQAKFLRIEDRVRFLGYVDSKMLPKIFGMADVFVLPSITAEAFGIVILEAMASGLPVIATDVGGIPEIVRESESGLLVPPGNELELRKAIQKLLLDDNLREWFGNNGRRAVEERYSWDKVAKQIEKTYEDILSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHJ6</accession>
    <name>F0LHJ6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Na(+) H(+) antiporter subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467621.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01348"/>
    <dbReference type="EnsemblBacteria" id="ADT84323">
        <property type="protein sequence ID" value="ADT84323"/>
        <property type="gene ID" value="TERMP_01348"/>
    </dbReference>
    <dbReference type="GeneID" id="10041664"/>
    <dbReference type="KEGG" id="tba:TERMP_01348"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1348"/>
    <dbReference type="eggNOG" id="arCOG01541">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_5_2"/>
    <dbReference type="OMA" id="YMEIASV"/>
    <dbReference type="OrthoDB" id="28394at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="2">
        <location>
            <begin position="122"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="505" mass="55951" checksum="A849679228E27586" modified="2011-05-03" version="1">MIPLLVACPLLFAFLVSLFDVLGVRDKITRFLFLTGAVSPWIVFFGVRAKIPLDEIVGRYAKTAGIQVSLDYINVYFVLAELILFFAVSIYSIEYFSKHRKNGKIYSLLLLMHAGLLGAFISRDLFNYYIYMEIASVSAFALIAISEEKGAKRAAYKYLILSLTASYLFVFAVGMMYLKTGYLNTELIRGSILPSREIDVAAGIAFSALLLKAGVFPLHSWLPDAHSKAPDPVSALLSGIVVKVPVYGMLLLYLSLPLTKRFLTVLMVVAFASIFFGIVLMIVESNIKKFLAYSTVSQVGYVVLGVSTSNILGSVYYAFAHALIKGALFLSAGALIRAQKSKEIRNLSYRGDAILMLSILMLSLAIGGVSPFVGAYGKSLLLEGMKKPLGYILYIAGIGTLAAFTKLNYYLLKSREHSNICLLQRMPPFLLSLLVLASGVYYGQRIDYMDFVLIVSAVMGFALLRRSGIIEKDIRYRFSKTVGEEINIFMAVFLLFTLFLLLQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHP6</accession>
    <name>F0LHP6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466428.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00153"/>
    <dbReference type="EnsemblBacteria" id="ADT83130">
        <property type="protein sequence ID" value="ADT83130"/>
        <property type="gene ID" value="TERMP_00153"/>
    </dbReference>
    <dbReference type="GeneID" id="10040471"/>
    <dbReference type="KEGG" id="tba:TERMP_00153"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.154"/>
    <dbReference type="eggNOG" id="ENOG502N5PB">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1168620_0_0_2"/>
    <dbReference type="OrthoDB" id="49331at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="237" mass="27201" checksum="4B23227B34FE423A" modified="2011-05-03" version="1">MSRVVDPKKLLTLFFVLLLFITSLSISLAQDVEIFNVYSFGDKAAFIVVNTTTFESYALIYNGSFVEIYPLNFSLRYTPVHWNGKYWLLQKGRRGTVELYIYNGTFKHIKTFKNGSLCVDNDLKIKWNSKEYFLTFIGASPYDNPNTGECILKFKHFLLKDGNLIPINVSGSPYWIPPLNVWLVGTSFVDEDGNITHLNIVNASLYSEGVAYNDTHVWLIIAWNSDTYTNVVIYRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHT0</accession>
    <name>F0LHT0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466462.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00187"/>
    <dbReference type="EnsemblBacteria" id="ADT83164">
        <property type="protein sequence ID" value="ADT83164"/>
        <property type="gene ID" value="TERMP_00187"/>
    </dbReference>
    <dbReference type="GeneID" id="26135517"/>
    <dbReference type="KEGG" id="tba:TERMP_00187"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.188"/>
    <dbReference type="eggNOG" id="arCOG01801">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033215_4_1_2"/>
    <dbReference type="OMA" id="TTGVYFP"/>
    <dbReference type="OrthoDB" id="56367at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42941">
        <property type="entry name" value="PTHR42941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02122">
        <property type="entry name" value="TRAP_TAXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="344" mass="37175" checksum="B4DF1E958DCCA8B9" modified="2011-05-03" version="1">MRRWKALGLVFVLVLALVAAGCTQKTTTTGTQTQAPIVTKNEEGKYEITIYTGSGPGSVYFAIGSMLAKVINKKSNLIAAKAVTSGASVANCKAIGKGEAQVAIAQNDVTWYAWEGKYQFEGNPIKVLRGIGTLYPEPVQIVVRADSDIKTLQDLAGKKVVVGAAGSGVAATAERVLKAAGVWDKIEPVYQTFEEAAQSLVLGQVDAEFTVIAYPAPAIDQIAVKVPVRLIPIPDDVIKKLHDQGYPFYVKVIIPKGTYKGMTEDTQTIAVKATLVVHKDLPDEVVYEITKILYENIDELAKAHQVAKQIDMKHAFDGLMIPLHPGAVKYYEEHGIKVPDNLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHZ0</accession>
    <name>F0LHZ0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467688.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01415"/>
    <dbReference type="EnsemblBacteria" id="ADT84390">
        <property type="protein sequence ID" value="ADT84390"/>
        <property type="gene ID" value="TERMP_01415"/>
    </dbReference>
    <dbReference type="GeneID" id="10041731"/>
    <dbReference type="KEGG" id="tba:TERMP_01415"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1415"/>
    <dbReference type="HOGENOM" id="CLU_357041_0_0_2"/>
    <dbReference type="OrthoDB" id="2903at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="665" mass="71686" checksum="A326CE6CD882CBF7" modified="2011-05-03" version="1">MKKRKIAGFALLLGIVMVGAFISGCIDQGNATETGTKTGGTTSQPTTTSPGISEEEKYQNNLLKAIATYDAEIVDIESRLKPSTLSGLAEETKALERDATHSTGREKTLLLEKLAYLKSLQLAELRNLIGISAVETAYWENTTTGEPIEGFYREDGKLFIVDNGKMVPLSRDEMVARMMELTKSYETRSMEIYHFGSGSLLQIREGGRTVGAGQLAVVRISVPKKGFMIQALGDSPGIMRLIDPGTGRTVLRVKPDGNGVYQVPPVNTTLVGIADDEGFCYRPLPLDSNTMNTIPEEPEDPLICPSPGLAPFIFEPGTGDVTVEPVPFEDAYLTGKTYGGITFELAVAPLGMLGRSETMLLVGVPENGTGIRVLSNSSKPGVMVLMDPKTGREIDRITPDKKGIYRIPGIDGEVIGFVAKADPPNGGFCYRPLELNINTTLEPMEICEEEFTMMPIIFEPSTNETFEPVSSQRADLKQLAEQLVNFRAETGRFAAGATGAGWVRDAPVGERVNDIRGVTPMKTGEYTAFRMERGNTAPFLKGILGDFGTGPFNPAPLPEFRYINVTDFGTGPFIPPVELAVMDSGGEVFVAVAGPAMTSKMPPEYLGGTFLEVWTGRNPQTGKEISVIALKVLDENGKVSIRAMTVVRDKPVRIGVFAPGNGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI03</accession>
    <name>F0LI03_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4338 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467701.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01428"/>
    <dbReference type="EnsemblBacteria" id="ADT84403">
        <property type="protein sequence ID" value="ADT84403"/>
        <property type="gene ID" value="TERMP_01428"/>
    </dbReference>
    <dbReference type="GeneID" id="10041744"/>
    <dbReference type="KEGG" id="tba:TERMP_01428"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1428"/>
    <dbReference type="HOGENOM" id="CLU_041281_0_0_2"/>
    <dbReference type="OrthoDB" id="144602at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025639">
        <property type="entry name" value="DUF4338"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14236">
        <property type="entry name" value="DUF4338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4338" evidence="1">
        <location>
            <begin position="36"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="377" mass="45429" checksum="4AE06F32C7C9BB86" modified="2011-05-03" version="1">MNEQNLDEIREKLISYFHELGFLVNPHLKPKDYSKDFLRLLHSKRRIEQLYKHKDFLEQYYPLIREYYKDMEINLEDIKLEVKFVERGTEEYILFKWWNLVWWSLPYEKSVGRRIYYMLFDKYHNLPFGLVVLQSPILYCKARDEYLGITKETRDYWINQSLYGQRIGALPPYNKIFGGKMVSMSLASVEIRKRYREKYKNKVTAKKKRILPARLLFIYTLSAYGRSKLYEDLYYDTLPLSIFVGYSSGAGTFHITDGIYKELLKILGENVNTSTFVSPSRKLKLVSRAFRILGLYGFEYHNIKRGVYLFPHVNNLREVINNNERPKWRNIKFENLFEHWLQNYVPDKLKRKKIKVSWGKLIKSVDYPFDKSKIHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI53</accession>
    <name>F0LI53_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466505.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00230"/>
    <dbReference type="EnsemblBacteria" id="ADT83207">
        <property type="protein sequence ID" value="ADT83207"/>
        <property type="gene ID" value="TERMP_00230"/>
    </dbReference>
    <dbReference type="GeneID" id="10040548"/>
    <dbReference type="KEGG" id="tba:TERMP_00230"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.230"/>
    <dbReference type="eggNOG" id="arCOG07627">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088146_0_0_2"/>
    <dbReference type="OrthoDB" id="126009at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="276" mass="32136" checksum="246A5300BAF37650" modified="2011-05-03" version="1">MKKVLGLLVAVILIMSFSGCLQGSKPPTKETILQAIDSVDTYTYEKKMIMRYPSLTRVVYIYSGINRQEKQFFELLEINATYSNGQFQRTKMLQYFDGSKNYVKMETNENGKETNGAWAFTINDIYKAYEQYYPDLPRDQVLNKFIESRDEILNVKDLLSKANITEITKKGDRYEIKFVLYRQYISTPSILQSYPGNASEVQEYMNVMRKLVRENIAGVLLVDKDGKPLLLKMKSNAKITYLYSNETIDATGDYTIKFSYEYNPPKWAEDLKRIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI54</accession>
    <name>F0LI54_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466506.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00231"/>
    <dbReference type="EnsemblBacteria" id="ADT83208">
        <property type="protein sequence ID" value="ADT83208"/>
        <property type="gene ID" value="TERMP_00231"/>
    </dbReference>
    <dbReference type="GeneID" id="10040549"/>
    <dbReference type="KEGG" id="tba:TERMP_00231"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.231"/>
    <dbReference type="eggNOG" id="arCOG07627">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088146_0_0_2"/>
    <dbReference type="OrthoDB" id="126009at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="267" mass="31552" checksum="390D40A69E172A12" modified="2011-05-03" version="1">MKKMLSLVFVILLTVKVSDCIQQTQQPTKVSIINALNNVDDYTHELSEKGIIGNRTYRIYSFIGIDRRTLQFFEFTKIETEEYTFKLWQYFDGSYVYFRVEDSEKNITRGGKASIDEIYKNMSIYYKNMSREEFIEMTVKTKDVLNNLKKMIENATITSIENDGELYKITFTLTRHYEKAPTFLNTNAENSEAIQGYINTLRRNVTENITGIVWVNNKSLPVKFKVEKSIIEKYRAANVTMHRHVEYNVTVTYKYQLPEWVYEVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI62</accession>
    <name>F0LI62_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable glycine dehydrogenase (decarboxylating) subunit 2</fullName>
            <ecNumber evidence="3">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Glycine cleavage system P-protein subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Glycine decarboxylase subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Glycine dehydrogenase (aminomethyl-transferring) subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvPB</name>
        <name evidence="4" type="ordered locus">TERMP_00239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GcvP family. C-terminal subunit subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466514.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00239"/>
    <dbReference type="EnsemblBacteria" id="ADT83216">
        <property type="protein sequence ID" value="ADT83216"/>
        <property type="gene ID" value="TERMP_00239"/>
    </dbReference>
    <dbReference type="GeneID" id="10040557"/>
    <dbReference type="KEGG" id="tba:TERMP_00239"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.239"/>
    <dbReference type="eggNOG" id="arCOG00076">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_5_0_2"/>
    <dbReference type="OMA" id="MHINLHK"/>
    <dbReference type="OrthoDB" id="8883at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00713">
        <property type="entry name" value="GcvPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023012">
        <property type="entry name" value="GcvPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="501" mass="56168" checksum="B26E2038AA029AC5" modified="2011-05-03" version="1">MYRQAKWDEPLIFELSKPGRIGFSLPEPIEDVEVDIPEKLKRKKLELPELSEPEVVRHYTRLSEMNYGVDSGMYPLGSCTMKYNPKINEEIAGHPKVAFIHPYQDERTVQGALQIMWELEQWLKEITGMDRFTLQPAAGANGEFTGVMIIRAYHLDRGETQRNEIIVPDSAHGTNPASAAMAGFKVIEIPSNEQGMVDLEALENAVSERTAGLMLTNPNTLGIFEEDILEIAKIVHKAGGLLYYDGANLNGILGKVRPGDMGFDVIHVNLHKTFSTPHGGGGPGAGPVGVKDFLKDYLPVPVVEYDEENNRYYLNYDLPKSIGKVKEFYGNFAVLVRALTYLKIMGKNGLKAVSEIAVLNANYLTQKLKGTRGYALPHKELRKHEVVFSAEPMKKETGVKALDVAKRLLDHGLHAPTIYFPLIVHEALMIEPTETVTKEDLDYYVEVLKKISEEAYSNPEVVKSAPHNTAVRRVDDVLAAKRPVITWRMYKQLKEKGEIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI97</accession>
    <name>F0LI97_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467725.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84427">
        <property type="protein sequence ID" value="ADT84427"/>
        <property type="gene ID" value="TERMP_01452"/>
    </dbReference>
    <dbReference type="GeneID" id="10041768"/>
    <dbReference type="KEGG" id="tba:TERMP_01452"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1452"/>
    <dbReference type="eggNOG" id="arCOG06115">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444603_0_0_2"/>
    <dbReference type="OMA" id="LGWMNKE"/>
    <dbReference type="OrthoDB" id="93282at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039519">
        <property type="entry name" value="YokE-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14470">
        <property type="entry name" value="bPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bPH_3" evidence="2">
        <location>
            <begin position="14"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="191" mass="22955" checksum="8D554A5CCC72939D" modified="2011-05-03" version="1">MQSLIYSRVILENLYPDEDVLYAIKKKFSLEAKPKWLVVTDRRILYVDEKLLGRYELTAVPYEKLELVYVKVGKIYSEFLIRKEDGKEIKLTKMDKEKARKAIEAIRDALNEIAVEPVTIERKKHLMSEEWVIHKPKEAVSRSIRMEPRKFREKREEDPLEKLKKLKELYDMGVITQEEYEEKRKKLLRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIB4</accession>
    <name>F0LIB4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rubrerythrin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01469"/>
    <dbReference type="EnsemblBacteria" id="ADT84444">
        <property type="protein sequence ID" value="ADT84444"/>
        <property type="gene ID" value="TERMP_01469"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01469"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1469"/>
    <dbReference type="eggNOG" id="arCOG01104">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="IAHESYK"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
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        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="174" mass="20801" checksum="306491E25E11AA78" modified="2011-05-03" version="1">MDNIHLGKLDIEKFIEELEKLSDREILSYWIKGELKEAELYKNLAIRAKKLGLEDRIVETFIILSKESKGHATRLWEIYKRLFRTEKLEEVELPPIEVEPLIDEFKETSNILGILELAMQSELLAKRIYRLLAKRTKDEKMKKIYEYLAAVEDEHYHKLKVEYEYCKKKAQINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIB8</accession>
    <name>F0LIB8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467746.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01473"/>
    <dbReference type="EnsemblBacteria" id="ADT84448">
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        <property type="gene ID" value="TERMP_01473"/>
    </dbReference>
    <dbReference type="GeneID" id="10041789"/>
    <dbReference type="KEGG" id="tba:TERMP_01473"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1473"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="4328at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00507">
        <property type="entry name" value="NI_HGENASE_L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="2">
        <location>
            <begin position="120"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="409" mass="46198" checksum="60906B340963A2E0" modified="2011-05-03" version="1">MPKTAYYIPIGPIHPALKEPIRVEAEVEGEKIVRVDVKRGFAHRGIEYMGMKRNAIQTLYLSERICGICSISHPYAFVVTAEKALGIEAPPRAQYIRPIIAELERIHSHILWLGVIAHEMGFDSLLFWTWKGREKVLDLLELLTGNRINYSVYMIGGVRRDLKESHIKAIKDAITYYWKFTEQMKEIILSDPVYKARTRGVAQLSKEMALKLNVVGPVARAAGIRMDIRQDMPYDAYADIDVRAVVPQDIVGEAKGDAYDITMVRIYEIEQSLDIIEYCVDNLPEGKILAIPNYPALLAKIRRTKGEAIGAHEAPRGEVVHYLKFDGRDGPSVWKVIAPSYNNINSWAPLLLGAEVADIPIVVAYIDPCMCCNDRVALLKTPEGKVLGYEYIHKKAVEKTRKIEKEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LID4</accession>
    <name>F0LID4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane bound hydrogenase NiFe-hydrogenase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467762.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01489"/>
    <dbReference type="EnsemblBacteria" id="ADT84464">
        <property type="protein sequence ID" value="ADT84464"/>
        <property type="gene ID" value="TERMP_01489"/>
    </dbReference>
    <dbReference type="GeneID" id="10041805"/>
    <dbReference type="KEGG" id="tba:TERMP_01489"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1489"/>
    <dbReference type="eggNOG" id="arCOG01553">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_2"/>
    <dbReference type="OMA" id="WVFHVNS"/>
    <dbReference type="OrthoDB" id="100307at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="1">
        <location>
            <begin position="27"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="151" mass="16542" checksum="0DB8CCF0F0E221EF" modified="2011-05-03" version="1">MLEKRIAKLCKYIGRSPWVFHVNSGSCNGCDIEIIAALTPRYDAERFGVKLVGTPRHADILLVTGPITDQSLERVKLIYEQTPDPKVVIAVGACPTGGSVFYESPFTNAPLDKHIPVDVFVPGCPPRPEAILYGVVLGLEKLIKKIEGEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIE8</accession>
    <name>F0LIE8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467776.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01503"/>
    <dbReference type="EnsemblBacteria" id="ADT84478">
        <property type="protein sequence ID" value="ADT84478"/>
        <property type="gene ID" value="TERMP_01503"/>
    </dbReference>
    <dbReference type="GeneID" id="10041819"/>
    <dbReference type="KEGG" id="tba:TERMP_01503"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1503"/>
    <dbReference type="eggNOG" id="arCOG04440">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145189_0_0_2"/>
    <dbReference type="OMA" id="YLMGYAV"/>
    <dbReference type="OrthoDB" id="109871at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019235">
        <property type="entry name" value="DUF2178_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09946">
        <property type="entry name" value="DUF2178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="156" mass="17853" checksum="600B7EE64263F6AD" modified="2011-05-03" version="1">MNEAIVNFIIWAFLATVTTLILLHLSKRDEKKKTLIPAMLVILTMGYLMGYAVSNGNLPLAFSVFLVGGIMLNLYYASMKRRGYVLEDERTLRIEEISARRTLQVFMIGLAFAVIYLSVAQQRNPALRDAFILAESLLVFLFFTHLAFKIYYSRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIG1</accession>
    <name>F0LIG1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00258"/>
    <dbReference type="EnsemblBacteria" id="ADT83235">
        <property type="protein sequence ID" value="ADT83235"/>
        <property type="gene ID" value="TERMP_00258"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00258"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.258"/>
    <dbReference type="HOGENOM" id="CLU_3113258_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="50" mass="6164" checksum="7C38C59925B4E1B2" modified="2011-05-03" version="1">MYIISGNGTFRLFYVSFDLRRTFTAISERTRLLSPKYQIIIEYEEKRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIH3</accession>
    <name>F0LIH3_THEBM</name>
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        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83247">
        <property type="protein sequence ID" value="ADT83247"/>
        <property type="gene ID" value="TERMP_00270"/>
    </dbReference>
    <dbReference type="GeneID" id="10040588"/>
    <dbReference type="KEGG" id="tba:TERMP_00270"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.270"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="105754at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="108" mass="12851" checksum="AE1D46544734C776" modified="2011-05-03" version="1">MTAPMERLKEKVTKEVLWLYILSLLKERPMYAYELKSRIREKFGFEPATVSSYVVLYKLEKDGYVTSKWQESETGKPSRKYYELTEKGRKLLEEGINFIENTLEKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LII1</accession>
    <name>F0LII1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MalE-like maltose/maltodextrin ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466553.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00278"/>
    <dbReference type="EnsemblBacteria" id="ADT83255">
        <property type="protein sequence ID" value="ADT83255"/>
        <property type="gene ID" value="TERMP_00278"/>
    </dbReference>
    <dbReference type="GeneID" id="10040596"/>
    <dbReference type="KEGG" id="tba:TERMP_00278"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.278"/>
    <dbReference type="eggNOG" id="arCOG00151">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_5_2"/>
    <dbReference type="OMA" id="WGGEMFG"/>
    <dbReference type="OrthoDB" id="14823at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="454" mass="50883" checksum="CF613AAD12A77977" modified="2011-05-03" version="1">MKKAYSFILVSVLLIAVVAAGCIGGGGETSSPPPTTVTTTKVETQTKIQTETKVQEKVFIRFAGWSAGETEMKNYQRIIGEFEQKYPNIGVKYEVIPQMFHENILASFGAGVAPDVFYVDSSWAPIFIDKGALYPISDLADKSFIDQFYPFLLKPFMKDGKLYGLPKDWSMLALFYNKKLFEQAGLTRPPQTWEELEEYAKIIADKTGKPGLAIYLGGFNRYVPVAVSNGAPKPWFEKPEDASWFDNPVVKETLTWYINLYKKGKIEREQQGKTPYVVQPSDVGAGWLGDAFGQQQVAMVISGNWMIPFLADQFPDFKYGEDWDIAPVPAGKKGRVTMAYTVILGINAKTEHPQEAWKFVEFVLGPYGQKELVVKAGHTLPSIKGFENDPDMWPQHKKTLSFKYDQMIVFLWGPKSGVLEGKFSDAMASAMRGEITVDEAIEVMKQIVQEELSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIP5</accession>
    <name>F0LIP5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="2">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467795.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01522"/>
    <dbReference type="EnsemblBacteria" id="ADT84497">
        <property type="protein sequence ID" value="ADT84497"/>
        <property type="gene ID" value="TERMP_01522"/>
    </dbReference>
    <dbReference type="GeneID" id="10041838"/>
    <dbReference type="KEGG" id="tba:TERMP_01522"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1522"/>
    <dbReference type="eggNOG" id="arCOG02199">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_1_0_2"/>
    <dbReference type="OMA" id="WDELIHR"/>
    <dbReference type="OrthoDB" id="50646at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="288" mass="32471" checksum="567544A24D4372F0" modified="2011-05-03" version="1">MYRILERKEIAMRNVWFKVHAPHIVRKLQPGQFIIVRAFENGERIPLTPVTWSREEGWIGLIVFTRGKTTMQINTELKEGDYFLNIAGPLGNPAPMKNYGKILAIGLYTGIVEVFPIARAWQEIGNEVHTLQVTFEPMILLKDELEKAVSKHTAVGVPLNPEKSFPENMKNVTARAREIVRDMIRNLKPDLVFMVGPVGDQKVIFEVVKEFNVPMLVDLHPIMVDGTGMCGACRVTVGGQIKFACVDGPTFNAYEVDFDELIKRSGYYGDLEMIAMQGYMQKIQGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIP9</accession>
    <name>F0LIP9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Drug/metabolite transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467799.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01526"/>
    <dbReference type="EnsemblBacteria" id="ADT84501">
        <property type="protein sequence ID" value="ADT84501"/>
        <property type="gene ID" value="TERMP_01526"/>
    </dbReference>
    <dbReference type="GeneID" id="10041842"/>
    <dbReference type="KEGG" id="tba:TERMP_01526"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1526"/>
    <dbReference type="eggNOG" id="arCOG00271">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064680_1_0_2"/>
    <dbReference type="OMA" id="ALNYTWP"/>
    <dbReference type="OrthoDB" id="53664at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="155"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="294" mass="32984" checksum="1593F88E9B8A953C" modified="2011-05-03" version="1">MHQQKSAYVYGSITVLLWSTVASAFKLSLRYLSYLNLLLYASFTSLFIFFILLVLQNKLYVVKKLSSNKYSAILGFVNPFLYYLVLFKAYSILPAQEAQALNYTWPIMLTLLSIPLLQQRIRLRNIFGIFISFSGVLIISTRGDMTALKFANPYGAFLGLMSALIWAVYWILNLRDGRDAVVKMFFNFAFGIMYIFLFVILTHNIVIPTAKGLAGALYVGTFEMGITFFLWLKALELSETTAQMANLVYLTPFISLIIIHFAVGERILISTIVGLALIVAGIIYGGAGRNNGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIS8</accession>
    <name>F0LIS8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate:ferredoxin oxidoreductase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of one alpha, one beta, one delta and one gamma chain.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467828.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01555"/>
    <dbReference type="EnsemblBacteria" id="ADT84530">
        <property type="protein sequence ID" value="ADT84530"/>
        <property type="gene ID" value="TERMP_01555"/>
    </dbReference>
    <dbReference type="GeneID" id="10041871"/>
    <dbReference type="KEGG" id="tba:TERMP_01555"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1555"/>
    <dbReference type="eggNOG" id="arCOG01608">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002569_5_0_2"/>
    <dbReference type="OMA" id="WNDQQDS"/>
    <dbReference type="OrthoDB" id="29908at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="3">
        <location>
            <begin position="262"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="394" mass="43834" checksum="E68F5B9C68C04150" modified="2011-05-03" version="1">MPMRKVMKGNEAAAWAAKLAKPKVIAAFPITPSTLVPEKISEFVANGELDAEFIKVESEHSAISACVGASAAGVRTFTATASQGLALMHEILFIAAGMRLPIVMAIGNRALSAPINIWNDWQDTISERDTGWIQFYAENNQEALDLILIAFKVAEDERVLLPAMTGFDAFILTHTVEPVEIPDQELVDEFLGEYKPKHAYLDPKRPITQGTLGFPAHYMEARYKVWEAMENARQVIKEVFEEFEKKFGRKYQMVEEYKTDDAEIIMITMGSLAGTLKEFVDKKREEGVKVGAAKITVYRPFPIEEIRALAKKAKVLAILEKDISFGSGGAVFADVARSLINEKEKPIVLDFIIGLGGRDVTFGQLEEALSIAEKAMKEGVEEEVYWIGLRKEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIT7</accession>
    <name>F0LIT7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467837.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01564"/>
    <dbReference type="EnsemblBacteria" id="ADT84539">
        <property type="protein sequence ID" value="ADT84539"/>
        <property type="gene ID" value="TERMP_01564"/>
    </dbReference>
    <dbReference type="GeneID" id="10041880"/>
    <dbReference type="KEGG" id="tba:TERMP_01564"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1564"/>
    <dbReference type="eggNOG" id="arCOG02732">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_848884_0_0_2"/>
    <dbReference type="OMA" id="GVFWEDV"/>
    <dbReference type="OrthoDB" id="81811at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="338" mass="39876" checksum="7956BFC67D95746B" modified="2011-05-03" version="1">MDKLKLYIIGFLVLIIAIAGGIVYKWGFWMLVRIVLSLGFLGLTLMLGFFLVLTLYAESWKYAAYLLVPTALSAYATYLSITWQKLKVVGGIIVLFILGLAFGIWYISEPDLSLADRFRSAEKLEKMGKYKAAARKYEKKGNYLKAAEMYEKLGWMESAAWAYEKAEKYEKAAEIYEQLYEKERDTYYLKEAHEYWKKAGNMERAAKALERYAEEEPWFWEDVAKLYEELGKEEKAKEAWQRALDYYMKEAQEEGVFWEDVGNIARKLGKEELAKEAYQKFLEYCLKEAEEDPMWWKHVAEAYEYLGEKDKAEEARKKYEEYRKKIMKANEETSKFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIX6</accession>
    <name>F0LIX6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxiredoxin</fullName>
            <ecNumber evidence="5">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_00345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodecamer. Pentamer of dimers that assemble into a ring structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00345"/>
    <dbReference type="EnsemblBacteria" id="ADT83322">
        <property type="protein sequence ID" value="ADT83322"/>
        <property type="gene ID" value="TERMP_00345"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00345"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.345"/>
    <dbReference type="eggNOG" id="arCOG00312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_4_4_2"/>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00401">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022915">
        <property type="entry name" value="Peroxiredoxin_TDXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="11"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="5 6">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Interchain (with Cys-220); in linked form" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Alternate" evidence="5">
        <location>
            <begin position="214"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with Cys-55); in linked form" evidence="5">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="225" mass="25844" checksum="5777DDCDB467B050" modified="2011-05-03" version="1">MKKQTRVIEMVVIGEKFPEVEVKTTHGVIKLPDYFAEKGKWFILFSHPADFTPVCTTEFYAMQKRLDEFKKLGVEPIGLSVDQVFSHIKWMEWIKENLGVEIEFPVIADDRGELADKLGMIPSGATITARAVFIVDDKGIIRAIVYYPAEVGRDWDEILRLVKALKISTEKGVALPHKWPNNELIGDKVIIPPASTIEEKKQREEAKAKGEIECYDWWFCYKKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ00</accession>
    <name>F0LJ00_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466644.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00369"/>
    <dbReference type="EnsemblBacteria" id="ADT83346">
        <property type="protein sequence ID" value="ADT83346"/>
        <property type="gene ID" value="TERMP_00369"/>
    </dbReference>
    <dbReference type="GeneID" id="10040687"/>
    <dbReference type="KEGG" id="tba:TERMP_00369"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.369"/>
    <dbReference type="eggNOG" id="arCOG01615">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078428_1_0_2"/>
    <dbReference type="OMA" id="AGCGWYS"/>
    <dbReference type="OrthoDB" id="44926at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015661">
        <property type="term" value="F:L-lysine efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005642">
        <property type="entry name" value="LysO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35804">
        <property type="entry name" value="PTHR35804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03956">
        <property type="entry name" value="Lys_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="193" mass="20638" checksum="D233307D46AA5368" modified="2011-05-03" version="1">MSFLYLVLVALSAGILVGKYTGFQFGNSYEIMLYALIFIIGVDLGKSRGLKEIRELGKIALILPLATVVGSLLGGLLASFLLNVPVKWALAISAGFGWYSLTGPLLAQYSPVYGVVGFLANLTREILTILFYPVAIRKIPKELAVSMGGATTMDSTLPVIVKFGGSEITVIAFVHGFILTAIAPFLIPLILQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ25</accession>
    <name>F0LJ25_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl21e</name>
        <name evidence="7" type="ordered locus">TERMP_00394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466669.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00394"/>
    <dbReference type="EnsemblBacteria" id="ADT83371">
        <property type="protein sequence ID" value="ADT83371"/>
        <property type="gene ID" value="TERMP_00394"/>
    </dbReference>
    <dbReference type="GeneID" id="26135735"/>
    <dbReference type="KEGG" id="tba:TERMP_00394"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.394"/>
    <dbReference type="eggNOG" id="arCOG04129">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103610_1_1_2"/>
    <dbReference type="OMA" id="KGMPHRR"/>
    <dbReference type="OrthoDB" id="107212at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00369">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_L21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_L21e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022856">
        <property type="entry name" value="Ribosomal_L21e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_L21e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="PTHR20981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="97" mass="11204" checksum="FEE0785A13542D3F" modified="2011-05-03" version="1">MVQKAHSFRRKTRGKLSKHPRRRGLPPLTRFLQEFEVGQKVHIVIEPSYHKGMPDPRFHGRTGTVVGKRGDAYIVQITDGGKVKTFFIHPVHLRPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ39</accession>
    <name>F0LJ39_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83385">
        <property type="protein sequence ID" value="ADT83385"/>
        <property type="gene ID" value="TERMP_00408"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00408"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.408"/>
    <dbReference type="HOGENOM" id="CLU_219594_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="39" mass="4632" checksum="400577FC9C017450" modified="2011-05-03" version="1">MENKCIRDNEVLSAVENFEIMLTQLIKILEKIKKKKLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ48</accession>
    <name>F0LJ48_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467868.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01595"/>
    <dbReference type="REBASE" id="29885">
        <property type="entry name" value="M.TbaMPORF1595P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84570">
        <property type="protein sequence ID" value="ADT84570"/>
        <property type="gene ID" value="TERMP_01595"/>
    </dbReference>
    <dbReference type="GeneID" id="10041911"/>
    <dbReference type="KEGG" id="tba:TERMP_01595"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1595"/>
    <dbReference type="eggNOG" id="arCOG02632">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013049_4_2_2"/>
    <dbReference type="OMA" id="NSADWAW"/>
    <dbReference type="OrthoDB" id="45297at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="4">
        <location>
            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="164"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="515" mass="59946" checksum="85658117A751381C" modified="2011-05-03" version="1">MERKLTEYVKLKQNKTVTREELERVLKKAADLIRTRVDYKYILLLLFLKRLSDEWEKEFEGYVEKLVKEGLDRKTAEKIALQDKSAYTIAYPSEYLWRKLREKDIEKLPQNLSEALKKLAELNPNLRGVVDRFDFMEFMLHRDNAEILKQLFELFSGLDLRNASPDVLGDAYEWILRYFAPQKAKEGEVYTPREVIKLLVEILDPRPGEEVYDPALGSGGMLIGSYLHVKEKFGESEAKKLFLYGQEVNPTTYAIAEMNMMIHGIKDAKLAVGDTLLRPAFKEGEKLKRFDVVIANPPWNQDGYGEETLKKAEFREERFKYGYPPNNSADWAWIQHMLASARDNGRIGIVIDNGALFRGGAEKKIRSRIVKEDLLECVILLPEKLFYNTGAPGAIMIFNKAKPKERKGKVLFINASLEYEKHPEVRKLNRLGEKNIEKIVKAYEEFEDVEGFARVVSLDEIKENDFNLNVTLYVFPMEEEEEIDVKAEWEELKKINEELAEIDEKIEEYLRELGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ87</accession>
    <name>F0LJ87_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467907.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01634"/>
    <dbReference type="EnsemblBacteria" id="ADT84609">
        <property type="protein sequence ID" value="ADT84609"/>
        <property type="gene ID" value="TERMP_01634"/>
    </dbReference>
    <dbReference type="GeneID" id="10041950"/>
    <dbReference type="KEGG" id="tba:TERMP_01634"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1634"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040020_1_0_2"/>
    <dbReference type="OMA" id="FGFHRMM"/>
    <dbReference type="OrthoDB" id="22281at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="13"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="395" mass="43416" checksum="5EFCBFB3A6A19584" modified="2011-05-03" version="1">MDKEKKIFGISWNVFLLGLVSFLNDMSSEMIAPIVPAYLTSVLNVGKLASGSIMGLIESLSSLFKVVFGHISDKFRQRKVFVTLGYGLSTISKGALAFTHSWWDFLSLRIVDRVGKGIRTAPRDALIAESTEKGKTGKSFGFHRMMDTMGAVAGPLVAIGLLALFVKYPADVAYRRIFLLSALPGALSILIIIFLVKDTGKEVKKKIRGISALRNRNLKLFLVVVAIGALGRYSYAFTMWKAQELGYSIVQSLGFYALFNVIYALSAYPIGVYSDKVGKKVIITAGFGVATLAALTFAYAKTLWMLLAGFILYGVYLAIEDTVPRAYMADLAKDFEKGTIIGAYHTVFGVFVFPASAIAGWLWQNYSLKYSFLYAAAMSAFAMILMMTMVKEEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJF6</accession>
    <name>F0LJF6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466720.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00445"/>
    <dbReference type="EnsemblBacteria" id="ADT83422">
        <property type="protein sequence ID" value="ADT83422"/>
        <property type="gene ID" value="TERMP_00445"/>
    </dbReference>
    <dbReference type="GeneID" id="10040763"/>
    <dbReference type="KEGG" id="tba:TERMP_00445"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.445"/>
    <dbReference type="eggNOG" id="arCOG02817">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_0_2_2"/>
    <dbReference type="OMA" id="FSIDTYH"/>
    <dbReference type="OrthoDB" id="86032at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="274" mass="30299" checksum="635EB88A4338BF20" modified="2011-05-03" version="1">MKFAGVNLEEPKIMGVINVSPESFYKGSVKQSEDELIRTALKMVEDGASFIDIGAKSTAPYLETQIPVEEEIRRAVWAISTLRDYVNVPISIDTTNAKVAEEAIKAGADIINDVSGLKGDSEMVKVAKEYGVPVIICAHGEVRDFMEPVHTVISFLQESLQIAYKNGIEKEKIAIDPAIGFLRPSYPPWYEWDSKVIANLNMLKMFGLPILVGVSRKSFIGAITGRKDPGERLPGSLATTAIAVWNGANIIRTHDVKETFDAVRLAWFIKRFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJM1</accession>
    <name>F0LJM1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydroorotase</fullName>
            <shortName evidence="3">DHOase</shortName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pyrC</name>
        <name evidence="5" type="ordered locus">TERMP_01688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467961.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01688"/>
    <dbReference type="EnsemblBacteria" id="ADT84663">
        <property type="protein sequence ID" value="ADT84663"/>
        <property type="gene ID" value="TERMP_01688"/>
    </dbReference>
    <dbReference type="GeneID" id="10042004"/>
    <dbReference type="KEGG" id="tba:TERMP_01688"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1687"/>
    <dbReference type="eggNOG" id="arCOG00689">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_1_2"/>
    <dbReference type="OMA" id="QHAQEPR"/>
    <dbReference type="OrthoDB" id="43469at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_A">
        <property type="entry name" value="PyrC_classI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="4">
        <location>
            <begin position="49"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="291"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="3">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="407" mass="46423" checksum="AA28118651FD77D1" modified="2011-05-03" version="1">MHELVLKGKFFVEKHVINGYIGVDNGKITKFSKKPLKGEKIIETKAHEVIMPGMIDVHVHLRDFNQNHKETIKSGTMAALHGGITTVFDMPNTDPPVMSKEIFEKRAELFKRKSYTDYALSFLIAGNCSEVKSGKADFYKIFMGASTGGIYSKNFEEDYKCANKRVSVHAEDYELIQKFPERPNIVEVKAIEKALNISKKLKKPLHICHVSTKEGLKRILEESLPWISFEVTPHHLFLNKKDFKKNPLLKVYPPLRSKEDVIYLWQNFEKIPIVASDHAPHTLDEKEEGAAGLPGLETELALLLTAYNKGMVSFWGIIEKTSLNPAKIFRIKNKGFEVGKDADLIVVNLKEEWKVQPEEFYTKAEWSPFEGWKLKGKVKITLLRGKVVMEDDEIVGKPRGERIVIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJZ0</accession>
    <name>F0LJZ0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6487 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466825.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00550"/>
    <dbReference type="EnsemblBacteria" id="ADT83527">
        <property type="protein sequence ID" value="ADT83527"/>
        <property type="gene ID" value="TERMP_00550"/>
    </dbReference>
    <dbReference type="GeneID" id="10040868"/>
    <dbReference type="KEGG" id="tba:TERMP_00550"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.551"/>
    <dbReference type="eggNOG" id="arCOG04457">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2662166_0_0_2"/>
    <dbReference type="OMA" id="CGGTMVK"/>
    <dbReference type="OrthoDB" id="119858at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045504">
        <property type="entry name" value="DUF6487"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20097">
        <property type="entry name" value="DUF6487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6487" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="82" mass="9357" checksum="EA259A347B7FE838" modified="2011-05-03" version="1">METKKCPFCGGTMIKGKSKFEGHAQYFWRAPWKHGLKAAFTGTVKAYPWLCIDCGAIIPYVDEAELQKIREEYEQAKLEGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJZ5</accession>
    <name>F0LJZ5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Probable cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cobQ</name>
        <name evidence="10" type="ordered locus">TERMP_00555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466830.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00555"/>
    <dbReference type="EnsemblBacteria" id="ADT83532">
        <property type="protein sequence ID" value="ADT83532"/>
        <property type="gene ID" value="TERMP_00555"/>
    </dbReference>
    <dbReference type="GeneID" id="10040873"/>
    <dbReference type="KEGG" id="tba:TERMP_00555"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.556"/>
    <dbReference type="eggNOG" id="arCOG00105">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019250_2_2_2"/>
    <dbReference type="OMA" id="EIHHGVA"/>
    <dbReference type="OrthoDB" id="34382at2157"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="8">
        <location>
            <begin position="5"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="9">
        <location>
            <begin position="250"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="483" mass="54139" checksum="21FA46ACEE802E39" modified="2011-05-03" version="1">MGKALMIQGTSSGAGKSLLTLALCRIFTDMGYDVVPFKSQNMSLNSAPSIEGGEISRAQYLQALACRKKPSINFNPILLKPEGNMRSQIVFMGKPIGSVSAREYMLSKKEELFKKAMQVLDELLEKHDIVVIEGAGSPVEINLKDYDIANMRVAKHANAKVILVTDIDRGGSFASIVGTMELLSKEERELVIGFVFNKFRGDVSLLKPGFDYLEKRYGKKVLGVIPYMEHKLPEEDSLVEFPKVKGDLHIQIIKLPHISNFTDFEPLHWANGVDYVTKAEEIEGDLIIIPGSKNTVEDLLWMRENGIEDAILEAHKDGAFVVGICGGFQMLGEKIIDNIESKRGKVRGIGLLKAKTVFAETKRTNHLKAEIMWEPMRGLNVDGYEIRMGRSVAKKPFSIIRKINGVKAFEPEGAVGKGVFGTYLHGIFHNFEFTEQFLNMLRLKKDLEPITVQKWSIEEEIERFAKIVERNLDISYILDSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK04</accession>
    <name>F0LK04_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kef-type K+ transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466839.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00564"/>
    <dbReference type="EnsemblBacteria" id="ADT83541">
        <property type="protein sequence ID" value="ADT83541"/>
        <property type="gene ID" value="TERMP_00564"/>
    </dbReference>
    <dbReference type="GeneID" id="10040882"/>
    <dbReference type="KEGG" id="tba:TERMP_00564"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.565"/>
    <dbReference type="eggNOG" id="arCOG01566">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046377_1_1_2"/>
    <dbReference type="OMA" id="KCATALM"/>
    <dbReference type="OrthoDB" id="19570at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="487" mass="53832" checksum="06A3083C75F4A1E7" modified="2011-05-03" version="1">MKVLILGGGAIGRTIAEALKGEFDITIIEKDELRARSLSESGFQVVHGDFSYTATLLKAHIDKADLAIITTMDVPTIKRTIQVIRSNNKSIPILTILPDDVSQEDIVNQIKEEFETEVKIDYAVSPRKAISKVVVDIVEMFGEKKNANLLAKKLQQLKQKGDGLLIVMHDNPDPDSMASAAALKTIAQNFGFKVHIVYGGEITHHENKALLNVLGVDMSKVSRGSYEIKRYPFIALIDSQPNGNLTILEEDDFKKIQIIIDHHQILQSLKEKLPQDAFVDIRPEVNATSSILAEYFKALNLPLNETLSTGLFYGIYVDTKKFSKLSHVDLKAIEFLAEKVNYELLDKIEHPDISTETAEILARAILNRKIYKNVVVSNVGFITNRDAIAESADFLLRLEGITTVLVFGIVDDRIEISARTRDVRINIGKVLKDAFGDIGSGGGHAQSGGARISLGIFKLAKDKSSLLRLAEEAITEKFLEALGVKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK59</accession>
    <name>F0LK59_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="2">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">coaD</name>
        <name evidence="4" type="ordered locus">TERMP_01796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468067.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01796"/>
    <dbReference type="EnsemblBacteria" id="ADT84771">
        <property type="protein sequence ID" value="ADT84771"/>
        <property type="gene ID" value="TERMP_01796"/>
    </dbReference>
    <dbReference type="GeneID" id="26137309"/>
    <dbReference type="KEGG" id="tba:TERMP_01796"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1795"/>
    <dbReference type="eggNOG" id="arCOG01223">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035272_5_0_2"/>
    <dbReference type="OMA" id="FDTLHSG"/>
    <dbReference type="OrthoDB" id="93412at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00647">
        <property type="entry name" value="PPAT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023540">
        <property type="entry name" value="PPAT_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="155" mass="17593" checksum="76001BE68D865B04" modified="2011-05-03" version="1">MRKYKKVVVGGTFDRLHLGHKALLRKAFEVGKYVYIGLTSDEMIKNKPYAEKILPYELRLKDLIKFFEVNGYKNYRIIKIHNAIGFADKLKSLDAIVVSEETYKGALIVNKAREEKGLKPLKIVKIGIIKSKLGCKISSSLIRAGLIDPFGNPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK84</accession>
    <name>F0LK84_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468092.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01821"/>
    <dbReference type="EnsemblBacteria" id="ADT84796">
        <property type="protein sequence ID" value="ADT84796"/>
        <property type="gene ID" value="TERMP_01821"/>
    </dbReference>
    <dbReference type="GeneID" id="10042137"/>
    <dbReference type="KEGG" id="tba:TERMP_01821"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1820"/>
    <dbReference type="eggNOG" id="arCOG04915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1933369_0_0_2"/>
    <dbReference type="OMA" id="FMVARGR"/>
    <dbReference type="OrthoDB" id="96780at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="131" mass="15267" checksum="177E4E306E9B9BDC" modified="2011-05-03" version="1">MFKLPERMEMIWLMKAEGLREIEIADTLGISRQAVNKALRDAKAKLFEMFLGLAEVFGFEVIRVNVEKGFMVTNAKIEHEVKRVYFFYIPKMGVRAFFEDSEFPEYLLKHAFEIGIVKNPVKGELIKMLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK85</accession>
    <name>F0LK85_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468093.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01822"/>
    <dbReference type="EnsemblBacteria" id="ADT84797">
        <property type="protein sequence ID" value="ADT84797"/>
        <property type="gene ID" value="TERMP_01822"/>
    </dbReference>
    <dbReference type="GeneID" id="10042138"/>
    <dbReference type="KEGG" id="tba:TERMP_01822"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1821"/>
    <dbReference type="eggNOG" id="arCOG10098">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1163855_0_0_2"/>
    <dbReference type="OMA" id="IALWTVY"/>
    <dbReference type="OrthoDB" id="85044at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="239" mass="26873" checksum="E371BE32FADD086C" modified="2011-05-03" version="1">MKLESVRPMNFSGIPFVLVVVSFVLLIVLPRLVSHVQGIFFVIGVFCLMASWGTGAEVEGNSIVLKYVFGKLKIRIPFDDIEEITTLNRLQKGAIAGYFKWEILLFIVFIAYALFDLITLPRGLLKGYYFGDIGLIVFGLFYIFAFVIPFSRKVFVAILAYSFVPVAIFLLYQKTGSITGDDIFMFIALVMVLGFAILDIYGKDYVLIRTKKNTYLLTCRSADEIVKALLKVAQNVQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKA2</accession>
    <name>F0LKA2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thermosome subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms a Heterooligomeric complex of two stacked eight-membered rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466858.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00583"/>
    <dbReference type="EnsemblBacteria" id="ADT83560">
        <property type="protein sequence ID" value="ADT83560"/>
        <property type="gene ID" value="TERMP_00583"/>
    </dbReference>
    <dbReference type="GeneID" id="10040901"/>
    <dbReference type="KEGG" id="tba:TERMP_00583"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.584"/>
    <dbReference type="eggNOG" id="arCOG01257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OMA" id="HRKGNTW"/>
    <dbReference type="OrthoDB" id="11742at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="552" mass="59645" checksum="B9EB9C07B0FB7D8A" modified="2011-05-03" version="1">MAQLVGQGGQPIVILPEGTQRYVGRDAQRLNILAARIVAETVRTTLGPKGMDKMLVDSLGDIVITNDGATILDKIDLQHPAAKMMVEVAKTQDEEAGDGTTTAVVIAGELLRKAEELIDQNIHPSIIVKGYTLAVEKAQEILGDIAIKVDPENEETLMKIAKTAITGKSAESHREHLARLAVEAVKQVAEKKDGKFEVDIDNIKIEKKEGESVEESQLIKGVVIDKERVHPRMPKRVERAKIALINDALEVKKTETDAKINITAPDQLYAFLEQEEKMIKDMVDQIVATGANVVFVQKGIDDLAQHYLAKAGILAVRRVKKSDMEKLAKATGAKIVTNVKDLTSEDLGYAELVEERKIAGENMIFVEGCKNPKAVTILIRGGTEHVIDEVERALEDAVKVVKDVMEDGAILPGGGATEIELSIRLDEYGKQVGGKEALAIEAFSDALKIIPKTLAENAGLDTIDVLVKVISEHKTKGKAIGIDVFAGEPADMLERGVIEPVRVKKQAIKSASEAAIMILRIDDVIAAKRVKSEGSGQGMEGMGGMGGMNMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKB0</accession>
    <name>F0LKB0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00591"/>
    <dbReference type="EnsemblBacteria" id="ADT83568">
        <property type="protein sequence ID" value="ADT83568"/>
        <property type="gene ID" value="TERMP_00591"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00591"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.592"/>
    <dbReference type="HOGENOM" id="CLU_3003344_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="56" mass="6440" checksum="7F0B384F99552FD3" modified="2011-05-03" version="1">MYYAVAYLRFGFKFPLFPVAMLFVGMIFYLNSRDQMILKIAGITEIIASLAFLILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKB1</accession>
    <name>F0LKB1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466867.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00592"/>
    <dbReference type="EnsemblBacteria" id="ADT83569">
        <property type="protein sequence ID" value="ADT83569"/>
        <property type="gene ID" value="TERMP_00592"/>
    </dbReference>
    <dbReference type="GeneID" id="10040910"/>
    <dbReference type="KEGG" id="tba:TERMP_00592"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.593"/>
    <dbReference type="eggNOG" id="arCOG09830">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2353348_0_0_2"/>
    <dbReference type="OrthoDB" id="141749at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="96" mass="9867" checksum="E5A7C472F774D782" modified="2011-05-03" version="1">MWRKALVLGLVLITIGMVVGGAVESSNIGLALWAWHAWHHKDTSGDKSTVEAGSAVTAAGSILWGIAERQAVRTTATVVASYLGLGLIGTGVLIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKE8</accession>
    <name>F0LKE8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polbeta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00629"/>
    <dbReference type="EnsemblBacteria" id="ADT83606">
        <property type="protein sequence ID" value="ADT83606"/>
        <property type="gene ID" value="TERMP_00629"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00629"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.631"/>
    <dbReference type="eggNOG" id="arCOG02105">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_1_2_2"/>
    <dbReference type="OMA" id="ARAFKEY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="121" mass="14477" checksum="2C37B06C72C8D753" modified="2011-05-03" version="1">MIEEVVEELKLYPWIIAVYLFGSQATGKAKPYSDYDICVITEPKITKAQRREILSFSSRKIDISIFWDLPIYIRFRVLSEGKPLFVRDEKKLHRIKARAFKEYWDFKPLLERHLKRVLSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKF7</accession>
    <name>F0LKF7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YcfH-like deoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466913.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00638"/>
    <dbReference type="EnsemblBacteria" id="ADT83615">
        <property type="protein sequence ID" value="ADT83615"/>
        <property type="gene ID" value="TERMP_00638"/>
    </dbReference>
    <dbReference type="GeneID" id="10040956"/>
    <dbReference type="KEGG" id="tba:TERMP_00638"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.640"/>
    <dbReference type="eggNOG" id="arCOG00891">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_5_2_2"/>
    <dbReference type="OMA" id="PNEAPRI"/>
    <dbReference type="OrthoDB" id="48998at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="253" mass="29538" checksum="70799004D8AAD2D7" modified="2011-05-03" version="1">MIDAHAHFEFYKRDAPKIIDECKAELKAVVDSITEYRKAHVWKSWEMLKPYFGFIFPTLGYHPNEARRGNWEKVRKVEEFIWDHKDEIVAVGEIGLDYHYAENEKQKENQMNIFKHFLKLALEIKKPVVIHARESEKEAYEIVQHYGVNAYFHSFAGSKELAKEIAENGHYIGINTGIVFIPEVKAAAEVLDVEAVLVETDSPYMSPFKGQRNKPCYVKVVIEEIAKLKELSFEEVERITEENAIKFFNLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKG8</accession>
    <name>F0LKG8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466924.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00649"/>
    <dbReference type="EnsemblBacteria" id="ADT83626">
        <property type="protein sequence ID" value="ADT83626"/>
        <property type="gene ID" value="TERMP_00649"/>
    </dbReference>
    <dbReference type="GeneID" id="10040967"/>
    <dbReference type="KEGG" id="tba:TERMP_00649"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.651"/>
    <dbReference type="eggNOG" id="arCOG05769">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2534861_0_0_2"/>
    <dbReference type="OMA" id="MLFKKRG"/>
    <dbReference type="OrthoDB" id="117061at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="82" mass="9447" checksum="2E27713DEB1E9127" modified="2011-05-03" version="1">MLFKKKGLFTVSDAMRVVEIASRENAKEIIVMCEVIDEDAKRRLWDYANAVRLMADLTGEQREVRIEILEGYVSDKVKGIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKK3</accession>
    <name>F0LKK3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468133.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01862"/>
    <dbReference type="EnsemblBacteria" id="ADT84837">
        <property type="protein sequence ID" value="ADT84837"/>
        <property type="gene ID" value="TERMP_01862"/>
    </dbReference>
    <dbReference type="GeneID" id="10042178"/>
    <dbReference type="KEGG" id="tba:TERMP_01862"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1861"/>
    <dbReference type="eggNOG" id="arCOG13122">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1307875_0_0_2"/>
    <dbReference type="OMA" id="KECIMGI"/>
    <dbReference type="OrthoDB" id="138129at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="210" mass="24566" checksum="D54D6F1997D351B0" modified="2011-05-03" version="1">MRQFTIFRKLEEIDRIRYVFKEFFEKLEKIVPSLVTEDGILEIFEQDMELIQEMYNRGEISRKEALQLLRELDEVADDLEEYVLRVRERLIELERENLAALGKLRKSIEPPQIGIPIVIVKEKIKDSIRKIAGSGLPKKDFGILNVSDYPRNYCKEEIKEKILGFLEEYSSGIVIARSELKECIMGILSERGMKFEVKEMGTKTIFIVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKL1</accession>
    <name>F0LKL1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468141.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01870"/>
    <dbReference type="EnsemblBacteria" id="ADT84845">
        <property type="protein sequence ID" value="ADT84845"/>
        <property type="gene ID" value="TERMP_01870"/>
    </dbReference>
    <dbReference type="GeneID" id="10042186"/>
    <dbReference type="KEGG" id="tba:TERMP_01870"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1869"/>
    <dbReference type="eggNOG" id="arCOG03839">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058982_0_0_2"/>
    <dbReference type="OMA" id="DFAYRNS"/>
    <dbReference type="OrthoDB" id="69374at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="338" mass="40598" checksum="0D844E89B353D300" modified="2011-05-03" version="1">MLNNELLFKIRESERKGFANFVSKKVGIKNVDMVEWDYIIHTILKELKKDPHFRENYVFKGGTYLVKCHLGYYRFSRDLDFAYRNSEELQEMSRSKLKKFLSEETGRIAETLNCIARDLGLEFYYRDHNDFNNHRYFSFLIGPGWFREIIAYSPAGEKIKLEFNYAEKFAFKPKTAKAHTLLSWKKAELKVRDYEKYIEFFGNHYPIRVSAYPDKEILIEKVRAILTRREFKLRDLYDLYKLHQVKGLKIKKYEKQIIMKVKNYISLSNNARENLLKTLEELKREDYLNVLKPEVEKDAVLIVEEFDKDKFFEFVESLRKELLELIESEGFAALIKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKN7</accession>
    <name>F0LKN7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468167.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01896"/>
    <dbReference type="EnsemblBacteria" id="ADT84871">
        <property type="protein sequence ID" value="ADT84871"/>
        <property type="gene ID" value="TERMP_01896"/>
    </dbReference>
    <dbReference type="GeneID" id="10042212"/>
    <dbReference type="KEGG" id="tba:TERMP_01896"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1895"/>
    <dbReference type="eggNOG" id="arCOG04849">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176008_0_0_2"/>
    <dbReference type="OMA" id="IRGKCPV"/>
    <dbReference type="OrthoDB" id="103145at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023811">
        <property type="entry name" value="CHP04076"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04076">
        <property type="entry name" value="TIGR04076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="113" mass="12290" checksum="56085A9531EB8DBD" modified="2011-05-03" version="1">MGKLIINVIEIRGKCPVFKVGDRIVIEGPQINLKETDAVCTHAFASLMPYIVALRKGIKPSELGLGKGGKAYVQCLDPGPPYTEGGTVIFEITVVKDEAEKSMENSERSDRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKQ6</accession>
    <name>F0LKQ6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA (pseudouridine(54)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trmY</name>
        <name evidence="6" type="ordered locus">TERMP_00658</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>pseudouridine(54) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:55292"/>
            <dbReference type="Rhea" id="RHEA-COMP:14140"/>
            <dbReference type="Rhea" id="RHEA-COMP:14141"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="EC" id="2.1.1.257"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the methyltransferase superfamily. TrmY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.257" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466933.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00658"/>
    <dbReference type="EnsemblBacteria" id="ADT83635">
        <property type="protein sequence ID" value="ADT83635"/>
        <property type="gene ID" value="TERMP_00658"/>
    </dbReference>
    <dbReference type="GeneID" id="10040976"/>
    <dbReference type="KEGG" id="tba:TERMP_00658"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.660"/>
    <dbReference type="eggNOG" id="arCOG01239">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107018_0_0_2"/>
    <dbReference type="OMA" id="HADHCII"/>
    <dbReference type="OrthoDB" id="126445at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18087">
        <property type="entry name" value="TrmY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00587">
        <property type="entry name" value="tRNA_methyltr_TrmY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007158">
        <property type="entry name" value="TrmY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40703">
        <property type="entry name" value="PTHR40703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04013">
        <property type="entry name" value="Methyltrn_RNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="201" mass="22603" checksum="C261EA1614742B7D" modified="2011-05-03" version="1">MRIFIIKANHAHTKADFSLKDLPGTSGRIDLLCRSINSAFLLSHGFRKNVRVWLNLNGPPNPPKTIRFEGSEIRPKTINPDERSIAKLIIKALKAGERIKDPSKEHQVLPGIHISNLTFEDIIRKTLKTAKLYYLHEEGKPIAEVNFKGNIAFILGDHVGLSDEDEAFLENIAEKISIGRKSYLTSHVIAYVNIFLDNLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKR3</accession>
    <name>F0LKR3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-phosphooligosaccharide-protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Oligosaccharyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">TERMP_00665</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.21" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466940.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00665"/>
    <dbReference type="EnsemblBacteria" id="ADT83642">
        <property type="protein sequence ID" value="ADT83642"/>
        <property type="gene ID" value="TERMP_00665"/>
    </dbReference>
    <dbReference type="GeneID" id="10040983"/>
    <dbReference type="KEGG" id="tba:TERMP_00665"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.667"/>
    <dbReference type="eggNOG" id="arCOG02044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_304340_0_0_2"/>
    <dbReference type="OMA" id="YGYWIES"/>
    <dbReference type="OrthoDB" id="5183at2157"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041530">
        <property type="entry name" value="OST_IS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041152">
        <property type="entry name" value="OST_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="PTHR13872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18246">
        <property type="entry name" value="OST_IS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18235">
        <property type="entry name" value="OST_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="OST_IS" evidence="18">
        <location>
            <begin position="593"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="OST_P2" evidence="17">
        <location>
            <begin position="805"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ADT83642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="947" mass="107931" checksum="D910EB9A0D7BAECB" modified="2011-05-03" version="1">MVKTKVKEKSGEQKTHSEQSFDFNKLRRYAFPILVVIVALIGFKIRYQTASYKYFIDPDTFYHFEIYKLTIKEWIPKYYMMADAPFGSKIAEPLGLYMLPALLYKFLSIFGYSEIAVFKLWPPLVGFFSIIAIYLLGKKFHSDWAGLWAALVMMFSTAHFVRTFSGNNRGDGPFLMLFLYAVIALFMYLDSKSRKRYLWGALFVIFSVTSLSVWNGSPFGLMVLLGFGSVYAILLFIFGKIEKFKEFIKDFYPAYFAVLILGYLLTLPGIIRVRSFIRFAFEVFIALVLLTLVMLYGERFKLNYSDRKHRFAVVAIIVLLGFAGAYAYVGPKLFKLMSGAYQSTQVYETVQELAKTTWNDVSRYYAVKSSDGMIFLISLLGILAVALRFVLSLSREGKIDEKQLFVLIYYTMSLYLMWTAVRFLFLASGAVILVFGILIGELFSFVENMKEKASTKALYAVLLIILFIPIPVVGATSMNSQAKAMARAGSVTPSWEETLKWLNQNTPKLSTATSWWDYGYWIESSLLGNRRAPADGGHARDRDYILARFLANDGTKSEVDFESWELNYFIVWTQDIFKFNAISYLGGAISRKERDNLGMILPFQKYGNNLYVLNQNQVIRVIEQNGKKKVIIQIQNQQLEPIQAIFVQTGEVVREQGTYPGIVWIFPNYALLTYHKIAFSNFIRMAFLGGNGVPNFRLVKSTGDINVYEFHPFVVYKIEVYKNGTWSPIKKLEPGEYKARLYISAFGRDVKDATIKLRAYKNGKLIADETIATNVNIDHLNEKPVEVMLNVPNATKYEIVLIQKGPVGALVSAPEFNGKLSNPIYVVPEGKSGKLTLKAEFDKDYTVSLYLRATIIYLVRTQGTNNEDENAAFEPYMDIIKYVPVKEGISVKAGVNTITADVEMPQVFAQYIEQLKQKYGADKVIIRGKRIEPVFIADKEYVIYSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKR6</accession>
    <name>F0LKR6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00668"/>
    <dbReference type="EnsemblBacteria" id="ADT83645">
        <property type="protein sequence ID" value="ADT83645"/>
        <property type="gene ID" value="TERMP_00668"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00668"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.670"/>
    <dbReference type="eggNOG" id="arCOG04362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062767_1_0_2"/>
    <dbReference type="OMA" id="GRFYHEY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013561">
        <property type="entry name" value="FilR1_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016490">
        <property type="entry name" value="Tscrpt_reg_HTH_AF0396-typ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08350">
        <property type="entry name" value="DUF1724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006692">
        <property type="entry name" value="TF_HTH_AF0396_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1724" evidence="1">
        <location>
            <begin position="172"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="234" mass="27347" checksum="60639226CC050AE5" modified="2011-05-03" version="1">MRELQNELRSTPSSILHALKALESRNIVRQNESTREYELTNIGYLVYIQLKNVVDSLEAISKFENFWLTHDVKPVPEEFLKTIGNLKNSKLVVASPDELKSPHELYTDLIKRAKWVRAISSVVFREYSDAFLELAFKGADIEAILPEKTYEKFINMLEDEELGALKKLSNMRIYTLEWNPRVSFTVTDYVLAFGLLFPDGRYDMTMDLVSYDPKARKWALDLFHHYKQFAKRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKR8</accession>
    <name>F0LKR8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Motifcytosolic fatty-acid binding proteins signature</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00670"/>
    <dbReference type="EnsemblBacteria" id="ADT83647">
        <property type="protein sequence ID" value="ADT83647"/>
        <property type="gene ID" value="TERMP_00670"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00670"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.672"/>
    <dbReference type="eggNOG" id="arCOG00561">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032023_0_0_2"/>
    <dbReference type="OMA" id="MLDIHVA"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="564" mass="65156" checksum="C555CACC00A3F291" modified="2011-05-03" version="1">MDSFKFLRKSLKQKRKEKMGEEMKRREKLYFALLALIIVGTFYYTYKQASSEGLYDYIGDEVWYVSASRNVLHRLGIDVHYINETTGSEGVNIVFLTEPEVKGEVKVSFWRFTILRTYTAAEPPKVPDFVSKLGIKVEYIPFNFSQEYNVDLMKVKIWQIAQKYNYTKYTPYTNFPAVYYEIPKSNFSRFVKDVKKIEGVDVIPGFRYPDKEGIQNYLNTEHPFLAKDFIMLGMLIQDKPVFWRLPGLIAHVIINLLVFFAALKITRSYLAAFIALVFSAFDPLLYATSLAAMLDIYVALFTAIFMYVMVIGDYPLSGISIGLAAAAKLNGAFPYPVLVIKALKDRMSLKRYLLILFVLPGIAFLIPEIPIIMAIGFQRWIEEFIASFSWHLSFKGEHPANSPFWQWFISLKPFPFHYNPDVFAATDPILMLSMIVFIFAIPYAAKKRGKILIPFGIFWSTIGFYALQWVLGGKTQFSFYATPLVPAGAVTLGVMAYELIKWEYFEESLKFYWGWILKIVDPIVRLIQKEFIQKTTKAKTEEKEPQEFTSENQEDSSAFFESEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKV8</accession>
    <name>F0LKV8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF357 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466985.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00710"/>
    <dbReference type="EnsemblBacteria" id="ADT83687">
        <property type="protein sequence ID" value="ADT83687"/>
        <property type="gene ID" value="TERMP_00710"/>
    </dbReference>
    <dbReference type="GeneID" id="26136113"/>
    <dbReference type="KEGG" id="tba:TERMP_00710"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.712"/>
    <dbReference type="eggNOG" id="arCOG01224">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180506_0_0_2"/>
    <dbReference type="OMA" id="GHLFTVE"/>
    <dbReference type="OrthoDB" id="126162at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036809">
        <property type="entry name" value="AF1782-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023140">
        <property type="entry name" value="DUF357"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04010">
        <property type="entry name" value="DUF357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158372">
        <property type="entry name" value="SSF158372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF357" evidence="1">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="95" mass="10985" checksum="7243CF7FD783DC49" modified="2011-05-03" version="1">MEREISEEKLKKYFEITEQALEKLEIAVHEKSLLYSVAKDFLTMAKSYYSDAKYYYEKGDYVTAFAALNYAHGFIDAGVRLGVFKGEDNRLFAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKW5</accession>
    <name>F0LKW5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multidrug resistance protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00717"/>
    <dbReference type="EnsemblBacteria" id="ADT83694">
        <property type="protein sequence ID" value="ADT83694"/>
        <property type="gene ID" value="TERMP_00717"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00717"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.719"/>
    <dbReference type="eggNOG" id="arCOG00132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046685_9_1_2"/>
    <dbReference type="OMA" id="VELFWGF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="378" mass="39736" checksum="EB3FAD484F90386D" modified="2011-05-03" version="1">MASSVLGPYLSLWLKGIGLGFSEIGLTQSVSEIAQLITDFPTGGVADRHGRVKTYAAGSSLFGIGLLIIGLTHTISAVLVGATLSGFGMALVSGTLVPWLYDALNDRKSVQQTLGKLKAISGPVRFAGGVIGGCLASVAPNLPVLTAGVLSIASAIIALFLLPDNCGNRKAKYMELLRRGLREIRKNRALHLLLASSFFLSFTARAFFTFWMLLLVQRGLPREYLGVLFALLLLSTSAGGLIAQKLEPTSKTAAMLTVLLGTEIAMLGIIENLAISIALLFALEVTLSARFPVMAVLRNSFIPKEVRSTVTSAMSTVGSGFTAISNVMVGAFAEKLSLGKAYFIAGSLGMLAALPLLGLTFLSVPDERGNMPEKVDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKZ9</accession>
    <name>F0LKZ9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468202.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01931"/>
    <dbReference type="EnsemblBacteria" id="ADT84906">
        <property type="protein sequence ID" value="ADT84906"/>
        <property type="gene ID" value="TERMP_01931"/>
    </dbReference>
    <dbReference type="GeneID" id="10042247"/>
    <dbReference type="KEGG" id="tba:TERMP_01931"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1930"/>
    <dbReference type="eggNOG" id="arCOG06879">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688136_0_0_2"/>
    <dbReference type="OMA" id="RAFRFGY"/>
    <dbReference type="OrthoDB" id="45588at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="407" mass="47341" checksum="CCAC1E6359577A48" modified="2011-05-03" version="1">MKTKIAEYLKALLKNTEKYLVIENEIAYIKDPVFGIVRNRVSAEYLKSIIRLYGESERDIIKKLVRFLLLRQNLNGSWNEIHPNYNQESALVTSFVGEALLLALPYLEGELKKRTENALRKARDYVLLSEIGQGYFLKSKLYTADYLNVDATCGAFLAQYYKVFGDKEALEGAKRAARRVCTFQEKDGAFPYTVNRGNEKYPLNVPCIHYQGVTLYYLSKVQEVIREEWLKECMLKGTQWLLNVQRNDGKFDWSKSGLMFAYYLTGAYAFGIASFVYTSQWDEKYLENATKLLPILGENTPNIVLRWEKGKWRDFPRDVVVSFKSAWLGNYPVKRKLFRLGYAVYRQIARRRFSEDVREDMVFKFVTKLFGIKASTVEPSKNFPDMFMTSEVLDCLSYALTFLKGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL08</accession>
    <name>F0LL08_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01940"/>
    <dbReference type="EnsemblBacteria" id="ADT84915">
        <property type="protein sequence ID" value="ADT84915"/>
        <property type="gene ID" value="TERMP_01940"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01940"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1939"/>
    <dbReference type="eggNOG" id="arCOG02717">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149108_3_0_2"/>
    <dbReference type="OMA" id="VIMIGPL"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002849">
        <property type="entry name" value="DUF131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01998">
        <property type="entry name" value="DUF131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="117" mass="12671" checksum="34F79B565663C457" modified="2011-05-03" version="1">MSSRSTITSIIELSGFALITFRLSFKNLQKYNLMMAMKGELLIIAGIAMIFIGFLLVFIGTLMTAAGGEAEVEGGGVIMIGPIPIVFGTQRGATLAMILAIILMLLWIFMALLNRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL43</accession>
    <name>F0LL43_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LrgA-associated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01976</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468246.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01976"/>
    <dbReference type="EnsemblBacteria" id="ADT84950">
        <property type="protein sequence ID" value="ADT84950"/>
        <property type="gene ID" value="TERMP_01976"/>
    </dbReference>
    <dbReference type="GeneID" id="26137519"/>
    <dbReference type="KEGG" id="tba:TERMP_01976"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1974"/>
    <dbReference type="eggNOG" id="arCOG05247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082099_0_1_2"/>
    <dbReference type="OMA" id="AQFVHFM"/>
    <dbReference type="OrthoDB" id="67305at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005261">
        <property type="entry name" value="CHP00659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PTHR30249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04172">
        <property type="entry name" value="LrgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00659">
        <property type="entry name" value="TIGR00659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="224" mass="23956" checksum="80C288F2D98BB59C" modified="2011-05-03" version="1">MNSFGIFLTLALFYLFSKLYQKKRSFYLNPVLLSILVIAVILKVFGISYQTYMESARILSFLLGPAVVSLAIPLYKQREVIKTYLKEIALGIPFGGLIAILSAFYVAKFLGAEEIVLLSIAPKSITTAIAIGVSEKIGGIPALTAVLVILTGIMGNAVGVEVLNLIRVKDRVARGLAMGVSSHGLGTARIILDDELAGAVSGLAMALNGVFTSLVLPYLIHVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL50</accession>
    <name>F0LL50_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468253.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01983"/>
    <dbReference type="EnsemblBacteria" id="ADT84957">
        <property type="protein sequence ID" value="ADT84957"/>
        <property type="gene ID" value="TERMP_01983"/>
    </dbReference>
    <dbReference type="GeneID" id="10042298"/>
    <dbReference type="KEGG" id="tba:TERMP_01983"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1980"/>
    <dbReference type="eggNOG" id="arCOG01766">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1324065_0_0_2"/>
    <dbReference type="OMA" id="KYALYGT"/>
    <dbReference type="OrthoDB" id="73081at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007366">
        <property type="entry name" value="DUF432"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04254">
        <property type="entry name" value="DUF432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019202">
        <property type="entry name" value="UCP019202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="212" mass="24288" checksum="4E31A5E601EA96BA" modified="2011-05-03" version="1">MFGEYDLKTRFIRVFDKKIHLTEETEDIVVYRRDEVKRIIKKSGKLKILPSPAIGYGVKLLMIRFDEPIAIPPKDTISGYAEAPVEVDVKLGKLTIDHFILGKEKYALYGTVDVGVITRYHKSPFYLKEPESVGIAKIVISNPSKEWKIVDRVVFPIKDSVMFFNAEKAYYPLLIVTLKTDTPEVNNTGKPPEENLIPTKEALSLPNFLMRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL77</accession>
    <name>F0LL77_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartate--tRNA(Asp) ligase</fullName>
            <ecNumber evidence="6">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">D-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aspS</name>
        <name evidence="8" type="ordered locus">TERMP_00751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467026.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00751"/>
    <dbReference type="EnsemblBacteria" id="ADT83728">
        <property type="protein sequence ID" value="ADT83728"/>
        <property type="gene ID" value="TERMP_00751"/>
    </dbReference>
    <dbReference type="GeneID" id="10041069"/>
    <dbReference type="KEGG" id="tba:TERMP_00751"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.753"/>
    <dbReference type="eggNOG" id="arCOG00406">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_2"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="24288at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
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    </dbReference>
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            <begin position="137"/>
            <end position="438"/>
        </location>
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            <begin position="192"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29991"/>
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            <begin position="214"/>
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        </location>
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            <begin position="409"/>
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        </location>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="438" mass="51093" checksum="7D5B47243ABCBD3F" modified="2011-05-03" version="1">MYRTHYSSQITEELNGQRVKVAGWVYEIKDLGGIKFLWIRDREGIVQVTAPKKKVSEEIFKLIPKLNSEDVVAVEGMVNFTPKAKLGFEIIPEKLEVLSKAETPLPLDPTGKVKAELDTRLDNRFIDLRKPEVMAIFKIRSNVFKAVREFFYNEGFIEIHTPKIIATATEGGTELFPMKYFEKDAFLAQSPQLYKQIMMASGLDRVFEIAPIFRAEEHNTTRHLNEAWSIDAEIAFIEDEDEVMQVLERLVAYTINYVREHNEKELKILNFELEEPKLPFRRITYTEALEILKDLGKNIPWGEDIDTEGEKLLGQYIKENYDEDLYFIYQYPSEAKPFYIMKYDDNPKISRAFDLEYRGVEITSGGQREHRYEILKQQIAEKGLNVESFEFYLKAFRYGMPPHGGFGLGAERLIKQMLNLGNIREVILFPRDRKRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
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                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
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    </dbReference>
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            <begin position="1"/>
            <end position="146"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
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    <sequence length="147" mass="16939" checksum="56582456F27FDA23" modified="2011-05-03" version="1">MEYLEIPLLDENGQEVKLRDFLGRWVVLYVYPRDNTPGCTIEAKEFTELLPEFEKLGVLVIGVSKDSVESHRRFKEKHNLKVKLLSDPEAKLIRSLGAWGRKMRGEGVLRSTFIINPEGEIVWEKKRVKAKGHAVKVLEVVKELVKK</sequence>
</entry>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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            <authorList>
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                <person name="Marteinsson V.T."/>
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            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <dbReference type="EMBL" id="ADT83758.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="101" mass="11556" checksum="D7E1671F4D0C63C8" modified="2011-05-03" version="1">MEAVKMFHFVEYGEFPIEEIPVEEVEEDALNVLRSTKVEKFQTSRGIVQKLSDNYGHYVGKIVGDYSIEELSIGSAYQTAFGIKVTLDYNDKIVGWLYLPE</sequence>
</entry>
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    <accession>F0LLB2</accession>
    <name>F0LLB2_THEBM</name>
    <protein>
        <submittedName>
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    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT83763">
        <property type="protein sequence ID" value="ADT83763"/>
        <property type="gene ID" value="TERMP_00786"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00786"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.788"/>
    <dbReference type="HOGENOM" id="CLU_3283043_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="40" mass="4512" checksum="B9623F33519C286C" modified="2011-05-03" version="1">MELLKKLEILLSSLIIEKKENATPVHVTAQKEECTKKDCG</sequence>
</entry>
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    <accession>F0LLB6</accession>
    <name>F0LLB6_THEBM</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00790</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="eggNOG" id="arCOG02979">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_942000_0_0_2"/>
    <dbReference type="OMA" id="EGGLPHY"/>
    <dbReference type="OrthoDB" id="63783at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="269" mass="30947" checksum="97441C84F591CE83" modified="2011-05-03" version="1">MKIAGVEGLDFKIPKEAWFSFFNTPYPGHKVGTAIDIYFLKKALFPFEEGKILEIKKFRTPRYIPVREDYLMIFQVDGFCLKVLHVKPSIKVGDKVYLGDEIGELVVSGFFRPWSDRHAHFELRDCKDRYRARGGFLMHPKILKLVPTIKGNKFEVVEKTEHYYWLKPLKKGKKNLTPLSFGGLPIEGGLPHYHYGAIFGKRRKVEILEAKFSVSQELPNGVGIFNADFQIFANQQKVKGIGVYCNQEKIKLIGGEFEIGDVVEIRFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLG0</accession>
    <name>F0LLG0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">30S ribosomal protein S24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps24e</name>
        <name evidence="7" type="ordered locus">TERMP_02015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468285.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02015"/>
    <dbReference type="EnsemblBacteria" id="ADT84989">
        <property type="protein sequence ID" value="ADT84989"/>
        <property type="gene ID" value="TERMP_02015"/>
    </dbReference>
    <dbReference type="GeneID" id="26137623"/>
    <dbReference type="KEGG" id="tba:TERMP_02015"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2012"/>
    <dbReference type="eggNOG" id="arCOG04182">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107248_3_2_2"/>
    <dbReference type="OMA" id="QYIRSYF"/>
    <dbReference type="OrthoDB" id="124805at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_S24e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_S24e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="PTHR10496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="99" mass="11647" checksum="27942B46746B9D6B" modified="2011-05-03" version="1">MEIRVTEIKENKLLGRKEIYFEIIHEGEPTPSRKDVKGKLVAMLDLNPETTVIQYIRSYFGSRVSKGYAKAYESKERMFYIEPEYILIRDGLIEKKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLH3</accession>
    <name>F0LLH3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2341 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02028"/>
    <dbReference type="EnsemblBacteria" id="ADT85002">
        <property type="protein sequence ID" value="ADT85002"/>
        <property type="gene ID" value="TERMP_02028"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02028"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2025"/>
    <dbReference type="eggNOG" id="arCOG03512">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008804_0_0_2"/>
    <dbReference type="OMA" id="YRVWGIS"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018765">
        <property type="entry name" value="DUF2341"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10102">
        <property type="entry name" value="DUF2341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2341" evidence="1">
        <location>
            <begin position="385"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="821" mass="93091" checksum="7B632CDE43FD3DE3" modified="2011-05-03" version="1">MKRRGFFLNSVVLLLLIPLLLLLATYEDVSSQVIQAQSVRTQAERTYRVASFLELDFQKALEISGKRAIITIIDYVSVTGDFISPTYMVNNTIRDLILEGTSPSLIGYDPNRVMRGQSLRRWLLNISADLRDQGFNISPSIDEILNSMEITVAPLDSFRVVIKARIPNITIRDVSGRIVYTGAIPSNGGYIYSIVDVQNLEDPIFSAMTGGRYYRSIRACPYSFPELLDKPIKVLEGNGSSTVDHFVEEFSRTVDPDRIYFGDYYPGTGAAAYVLLNNPEQNVTEPIVFNTTLNGRRTSPLEVFNEGDMGVLVFGNVSGAGGTGTATSWCSLLEYRLNVTIQNRINQELKNFQVPITIDSTTLPDPALTTFFRTADSDGDNIPIIEFYDENCNPMNFWVEKWDTNTKQAVIWVNVTIPANSQITIAIYFDSNGVETLGDPDKVFDFYDDFEGSSLDTTKWTTNTNQYSLENGLIKMWGNWNNQYYINTLKSFAPNVIIEGVWRLGGYTYWRGRRIFSYDTDLTIGLVPSETSTWLDDSAIYAWYDGYDYNLNPWNYKTLRIYGSYIPNLQQIQSTDWQNFEIIYTNTQIQFWDSYTNTWLIGSVYPPLSSFHLQIAADTDSDTRYGYIDWIRVRKYAPTPPTVMISQNIETKPSSTTTATTTSSARAYDIQPFIDCIMDQRYFGIYNAPSFFERLEGSTINHAAYEALAHQLQDELGVKYGSQYYPIGLVSFMIPDPTYDQKLFDLFNTLGLSIEEGQTSFDYYFLQYYFKGGAKVTGYRMWGVSQGVTSQGDLSSVPFFIDNQTAVAIFGVQGAQDLLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLH9</accession>
    <name>F0LLH9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ordered locus">TERMP_02034</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468304.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02034"/>
    <dbReference type="EnsemblBacteria" id="ADT85008">
        <property type="protein sequence ID" value="ADT85008"/>
        <property type="gene ID" value="TERMP_02034"/>
    </dbReference>
    <dbReference type="GeneID" id="10042349"/>
    <dbReference type="KEGG" id="tba:TERMP_02034"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2031"/>
    <dbReference type="eggNOG" id="arCOG04421">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061495_2_0_2"/>
    <dbReference type="OMA" id="EFCYKND"/>
    <dbReference type="OrthoDB" id="47738at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01415">
        <property type="entry name" value="SAICAR_synt_PurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033934">
        <property type="entry name" value="SAICAR_synt_PurC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="3"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT85008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="229" mass="26428" checksum="615B48139BC7A92F" modified="2011-05-03" version="1">MEVYEGKAKKMIPLDDGKYLMEFKDDATAFDGKKKAQFKGKGWLNAQISAKIFKLLEEHGIKTHFIGIAGDNKLIVEKLEMYPIEVVVRNIVAGSLKRKLPLKEGTELKEPIVELYYKSDELGDPMINYYHAKILGVSEEEIKEMEKIALKVNEVLREYFKEKGILLVDFKLEFGKNAKGEIVLADEISPDTCRFWDAETKKSLDKDVFRFDKGDLISAYEEIYRRIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLK2</accession>
    <name>F0LLK2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468327.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02057"/>
    <dbReference type="EnsemblBacteria" id="ADT85031">
        <property type="protein sequence ID" value="ADT85031"/>
        <property type="gene ID" value="TERMP_02057"/>
    </dbReference>
    <dbReference type="GeneID" id="26137671"/>
    <dbReference type="KEGG" id="tba:TERMP_02057"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2054"/>
    <dbReference type="eggNOG" id="arCOG02836">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194986_0_0_2"/>
    <dbReference type="OMA" id="RIKYTTV"/>
    <dbReference type="OrthoDB" id="130741at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="76" mass="8937" checksum="47A8C0E7A0EE1F27" modified="2011-05-03" version="1">MGEDERKYTTVSIPKPLYEKIKKRIEGTGFTSVSDYVTYVLREVLASLEEEEKEEVFSEEEEEKVKERLRALGYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLL1</accession>
    <name>F0LLL1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-glycerate 2-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467086.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00811"/>
    <dbReference type="EnsemblBacteria" id="ADT83788">
        <property type="protein sequence ID" value="ADT83788"/>
        <property type="gene ID" value="TERMP_00811"/>
    </dbReference>
    <dbReference type="GeneID" id="10041129"/>
    <dbReference type="KEGG" id="tba:TERMP_00811"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.813"/>
    <dbReference type="eggNOG" id="arCOG04170">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032279_1_1_2"/>
    <dbReference type="OMA" id="GKAAWRM"/>
    <dbReference type="OrthoDB" id="53827at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="PTHR12227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF4147" evidence="2">
        <location>
            <begin position="21"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="1">
        <location>
            <begin position="334"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="449" mass="48106" checksum="ED2CFA294C17F31E" modified="2011-05-03" version="1">MNINKDELLSYGDVKAKEIALTLMEEAIKSSDPYEAVKRALKMKDDKLIVMGKEFPIKGKIYVLAFGKAACSMAKAVEEILRDKLEEGIAVTKYGYALPLKKIEVIEAGHPIPDENSMKGALAGVELAKKVDKDDILLVLISGGGSALFCLPEDGISLEDKIKTNELLLKSGAKIYEINTVRKHISKVKGGKLAKLVKGTLISLILSDVVGDPLEAIASGPTVKDPTTFEDAYRILKVYGIWEEIPEGVKRHIEKGLKGEVEETLKENLPNVHNFIIGSVSKACESARGKAEELGLKAYILTTTLEGEAKDVALALGSIIEEIYNKNRPFEKPVVLIAGGETTVTILGKAGMGGPNQEIALSISRKISGLRGTAVLAMDTDGTDGPTDAAGGLVDSYTLDVLKKGGTDVDEYLATHSTYDALKKAKALLITGPTRTNVNSIFIAVIGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLN4</accession>
    <name>F0LLN4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00834"/>
    <dbReference type="EnsemblBacteria" id="ADT83811">
        <property type="protein sequence ID" value="ADT83811"/>
        <property type="gene ID" value="TERMP_00834"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00834"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.837"/>
    <dbReference type="eggNOG" id="arCOG01975">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2597923_0_0_2"/>
    <dbReference type="OMA" id="PVIGIFY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="79" mass="8686" checksum="5B1386838C3C226D" modified="2011-05-03" version="1">MLGVTGVPVIGIFYDNRLVAIVEGEIPEPSKNVPIIVETAIKEKGVLFITDKTYLIPLNQTETIKKLENIFMNGEPSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLR8</accession>
    <name>F0LLR8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylglucosamine 2-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467143.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00868"/>
    <dbReference type="EnsemblBacteria" id="ADT83845">
        <property type="protein sequence ID" value="ADT83845"/>
        <property type="gene ID" value="TERMP_00868"/>
    </dbReference>
    <dbReference type="GeneID" id="10041186"/>
    <dbReference type="KEGG" id="tba:TERMP_00868"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.871"/>
    <dbReference type="eggNOG" id="arCOG01392">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041674_0_1_2"/>
    <dbReference type="OMA" id="RYNTERP"/>
    <dbReference type="OrthoDB" id="18594at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="377" mass="42740" checksum="8974CC1DFDB939CA" modified="2011-05-03" version="1">MKPAFVFGTRPEIIKLAPVIREFEKRGIKPLLIHTGQHYDYEMSRIFLEELELNSIDYHLEVGSGTQAEQTGIAMIKIEKVLMKEKPDVTLVQGDTNTVLAGALASVKLKIPVAHVEAGLRSFDRTMPEEINRILADHASEVLFAPTEEAKKNLENEGIREGVYVVGNTIVDAVLQNSEIAERKSDVLDRFNLTPKEYILITAHRAENTDSKENLKKLVEILEALPIKAVYPMHPRTRNRLKEFGLWERVKKIENLIITQPLGYLDFLKLQKNAKIVMTDSGGVQEESIILNVPCLTLRYNTERPETVKAGGNILVGLEKDRALYYVNKLLNNKEFYEKMASAENPFGDGKAGERIVKILLELYERGELKVRSSRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLS6</accession>
    <name>F0LLS6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Peptide chain release factor subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Translation termination factor aRF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prf1</name>
        <name evidence="11" type="ordered locus">TERMP_00876</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467151.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00876"/>
    <dbReference type="EnsemblBacteria" id="ADT83853">
        <property type="protein sequence ID" value="ADT83853"/>
        <property type="gene ID" value="TERMP_00876"/>
    </dbReference>
    <dbReference type="GeneID" id="10041194"/>
    <dbReference type="KEGG" id="tba:TERMP_00876"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.879"/>
    <dbReference type="eggNOG" id="arCOG01742">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035759_3_0_2"/>
    <dbReference type="OMA" id="GQEMEVV"/>
    <dbReference type="OrthoDB" id="32191at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00424">
        <property type="entry name" value="Rel_fact_arch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020918">
        <property type="entry name" value="Peptide_chain-rel_aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PTHR10113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="SSF55481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03676">
        <property type="entry name" value="aRF1/eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="415" mass="47363" checksum="5A4E262CAA70D943" modified="2011-05-03" version="1">MSHTSAEMYELKKKVEELKKFRGRATELVSLYIPAGYDLNKVMQQLREEYGTAQNIKSKSTRKNVLGALERAMQHLKLYKQTPPTGLALFVGNVSEQEGVSDIRVFAVIPPEPLKVRLYRCDQTFVTEPLEEMLRVKDAYGLITVEKNEATIGILRGKRIEVVDELTSNVPGKTRAGGQSARRYERIREQETHEFMKRIGEHANKAFLPLLEKGELKGIIVGGPGPTKEEFIEGDYLHHELRKKIIGVVDISYHGEYGLRELVEKASDILSEHEAIKEKKLIQDFFRHLVKDTGMITYGEKEVRRALELGAVDILLISEGYDKVRVKAKCNNCGWEELKTMNEQEFEVYRRKLKTCPKCGSQNISFEKWDVAEELIKMAEGIGARVEIISLDTEEGQQFYKAFGGLGAFLRYKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLV6</accession>
    <name>F0LLV6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468351.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02081"/>
    <dbReference type="EnsemblBacteria" id="ADT85055">
        <property type="protein sequence ID" value="ADT85055"/>
        <property type="gene ID" value="TERMP_02081"/>
    </dbReference>
    <dbReference type="GeneID" id="10042396"/>
    <dbReference type="KEGG" id="tba:TERMP_02081"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2078"/>
    <dbReference type="eggNOG" id="arCOG11056">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2875265_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="63" mass="7547" checksum="72AB7D38E4E1DCD6" modified="2011-05-03" version="1">METKYKKIEFEFELPDDVNIEEIRESLKRIILRYLKEEGLSEKELEKVKISIELVEGNEESES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLX3</accession>
    <name>F0LLX3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468368.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02098"/>
    <dbReference type="EnsemblBacteria" id="ADT85072">
        <property type="protein sequence ID" value="ADT85072"/>
        <property type="gene ID" value="TERMP_02098"/>
    </dbReference>
    <dbReference type="GeneID" id="10042413"/>
    <dbReference type="KEGG" id="tba:TERMP_02098"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2095"/>
    <dbReference type="eggNOG" id="arCOG01378">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_686773_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="393" mass="45168" checksum="E23B2647EF5239E1" modified="2011-05-03" version="1">MKILGIFIDALNPGFINETDTPFLYRLSNRGENIVSLESVLGFSTTIGATIFTGTYPDRHGIWIEYYYNPNYSPYSKIPLIKLSKPIDYIPIQIIRSGINFLLSKYVYPYYAKKLGYSELAPYNIPYKIITYFDVVTFKHYTEPKAFPVPSLVDVLIENGVSFYYSTHISEATLKNALSSDVSIFYFSKADLVGHIFGVGSKQHRNTLREIDRKVEHLVNTYRRKFGNNFEVLVFSDHGMANVNKKISTISWVKDKELGKKYLIAIESTMMRFWYFDERYKEKIREKLNSLGYGHLLSTKEKKQLRIHFSDNKYGEDIFLVDQGYVLYPSFKSWSIPKAMHGYHPALKEQQAVLISPTISGITEASVVDIMPTILKLLDLEIPKTVEGQPLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLX5</accession>
    <name>F0LLX5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468370.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02100"/>
    <dbReference type="EnsemblBacteria" id="ADT85074">
        <property type="protein sequence ID" value="ADT85074"/>
        <property type="gene ID" value="TERMP_02100"/>
    </dbReference>
    <dbReference type="GeneID" id="10042415"/>
    <dbReference type="KEGG" id="tba:TERMP_02100"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2097"/>
    <dbReference type="eggNOG" id="arCOG00894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_2_2"/>
    <dbReference type="OMA" id="TEYSMSK"/>
    <dbReference type="OrthoDB" id="17570at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="296" mass="32280" checksum="653243B08DE5912C" modified="2011-05-03" version="1">MSNDGSRVLIVIPAYNEELTIGSVVALAKKYGDVLVVDDGSKDRTSEIAREVGAVVLKHKTNRGKGQALKTGFEHALANDYDAVVCLDADGQHNPEEIPLLLKPIIEGEADLVIGSRYLNNAHKNIPFYRRLGLWVLNKTTVLASGVKITDSQSGFRALSRKALKSLELNADGYHVESEMIHELAEKGLKIVEVPINVRYDVPKKHKKNPVSHGVGVLAKVVGLIGYKRPLLLFSILSLISFAVAGVFAYWALKPYWSGGDVFLTQAIAAGIFTLIGIQLFIAGLTLNVLARMVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM71</accession>
    <name>F0LM71_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="9">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lysS</name>
        <name evidence="11" type="ordered locus">TERMP_00942</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467216.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00942"/>
    <dbReference type="EnsemblBacteria" id="ADT83918">
        <property type="protein sequence ID" value="ADT83918"/>
        <property type="gene ID" value="TERMP_00942"/>
    </dbReference>
    <dbReference type="GeneID" id="10041259"/>
    <dbReference type="KEGG" id="tba:TERMP_00942"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.945"/>
    <dbReference type="eggNOG" id="arCOG00485">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025562_1_0_2"/>
    <dbReference type="OMA" id="DWPMRWA"/>
    <dbReference type="OrthoDB" id="9880at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:tRNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00177">
        <property type="entry name" value="Lys_tRNA_synth_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002904">
        <property type="entry name" value="Lys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042078">
        <property type="entry name" value="Lys-tRNA-ligase_SC_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37940">
        <property type="entry name" value="PTHR37940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01921">
        <property type="entry name" value="tRNA-synt_1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00467">
        <property type="entry name" value="lysS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anticodon_2" evidence="10">
        <location>
            <begin position="445"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="30"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="280"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="526" mass="61498" checksum="ABB29ACD099E81AD" modified="2011-05-03" version="1">MVHWADYMAEKIIRERGDKEEYVVESGITPSGYVHIGNFRELFTAYIVGHALKDKGKKVRHIHMWDDYDRFRKVPKNVPGEWKEYLTMPVSEVPDPWGCHNSYAEHFMELFESEVEKLGIEVDFLRASRLYKTGEYAKDIRKALENREKIVAILNKFRDMAKQPHLEESWQPVQIYCPKCRKEADFIQWDGGWKVEYKCPHCGSEGKTDIREGNVKLRWRVDWPMRWAHFGVDFEPAGKDHLAAGSSFDTGREIIKTVYGKEPPLTLMYEFVGIKGQKGKMSGSKGNVILLSDLYEVLEPGVIRFLYARHRPNKEIKIDLGLGLLNLYDEFDKVERIYFGLENAKNKEEEIELKRTYELSMPKIPERLVAQAPFRFLVVLVQMPHLDEGKIIEILKKQGHIPQDLAEEDTERIKLRIMLAKNWVSKYAPDTVKFSLLQEPPRIEISEEIKEALNEVANWLESREEFSVDELNNIIFDAAKKRNIPSKQWFKILYQLFIGKDRGPRLASFLASLDKDFVTRRLRLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM76</accession>
    <name>F0LM76_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467221.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00947"/>
    <dbReference type="EnsemblBacteria" id="ADT83923">
        <property type="protein sequence ID" value="ADT83923"/>
        <property type="gene ID" value="TERMP_00947"/>
    </dbReference>
    <dbReference type="GeneID" id="10041264"/>
    <dbReference type="KEGG" id="tba:TERMP_00947"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.950"/>
    <dbReference type="eggNOG" id="arCOG00662">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054041_0_0_2"/>
    <dbReference type="OMA" id="NRPFYNE"/>
    <dbReference type="OrthoDB" id="48312at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="21"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="318" mass="36546" checksum="B7F9AEB78648C4A7" modified="2011-05-03" version="1">MLIRVSYGTAIAMGLIKAKMLARPTTAYLMIYHNGRCINNCAFCPQARESRADLKKLSRVTWPVFDLKTVLEKLKNGKFARICLQTVDYEGLEEDVLTLLGAFYSLNLPISVSITPVDRRYLQKFRELGVDYIGVGLDVASERLYNEIKESLYSWDEMWRFTKDVIEIFGEKKAFVHLIIGLGETDKEALEAIQKAYDIGAEVSLFAFTPIKGTKLENLKPPGLNRYRKIQIGHYLIKNEIKRVEEFKFDDKGNVLSFGISKEDLMKVLQEIAVMTHGCPGCNRPYYNERPSNEPYNFPVKPKEEYLIKLIEKIFSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM77</accession>
    <name>F0LM77_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467222.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00948"/>
    <dbReference type="EnsemblBacteria" id="ADT83924">
        <property type="protein sequence ID" value="ADT83924"/>
        <property type="gene ID" value="TERMP_00948"/>
    </dbReference>
    <dbReference type="GeneID" id="10041265"/>
    <dbReference type="KEGG" id="tba:TERMP_00948"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.951"/>
    <dbReference type="eggNOG" id="arCOG08603">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1674076_0_0_2"/>
    <dbReference type="OMA" id="YFEACFR"/>
    <dbReference type="OrthoDB" id="84647at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="175" mass="20789" checksum="8027FD0A4398DF9E" modified="2011-05-03" version="1">MEKKPRFLKEFEMWERRRKIAELFREALEAENKGEFETAKKKLDKVLELSKDYFPEIYFEACFKLAEVFFEEDNYRGSIKCALRALYNAPNRDLYLVGIERIRDMLFILKERGNLEVFKENMESMCRYLESNEELYAFVRGLIAIAEGEKDITKYLESISTPELKKALGVLIKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMA8</accession>
    <name>F0LMA8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468427.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02157"/>
    <dbReference type="EnsemblBacteria" id="ADT85131">
        <property type="protein sequence ID" value="ADT85131"/>
        <property type="gene ID" value="TERMP_02157"/>
    </dbReference>
    <dbReference type="GeneID" id="26137751"/>
    <dbReference type="KEGG" id="tba:TERMP_02157"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2153"/>
    <dbReference type="eggNOG" id="arCOG05776">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1754808_0_0_2"/>
    <dbReference type="OMA" id="YNFSFFE"/>
    <dbReference type="OrthoDB" id="88506at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="147" mass="17033" checksum="463D57E900DFD243" modified="2011-05-03" version="1">MINLYAIVQRDLAKDLIFEIDDEIVTLSIKGVMIARTDSKSYNFSFVEITETEFVLALQMKGYIIYLGLESDEEIDEDAYPELVRALIQQLIPVLNNLIQEAEKSGYKGKADLLMDDNMSPDMKEFFYEMLIRHKKNLPHYEQVDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMB1</accession>
    <name>F0LMB1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycogen branching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_02160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468430.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02160"/>
    <dbReference type="EnsemblBacteria" id="ADT85134">
        <property type="protein sequence ID" value="ADT85134"/>
        <property type="gene ID" value="TERMP_02160"/>
    </dbReference>
    <dbReference type="GeneID" id="10042475"/>
    <dbReference type="KEGG" id="tba:TERMP_02160"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2156"/>
    <dbReference type="eggNOG" id="arCOG03281">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06233">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008192_1_0_2"/>
    <dbReference type="OMA" id="CAYYEGL"/>
    <dbReference type="OrthoDB" id="4556at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037090">
        <property type="entry name" value="57_glycoside_trans_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015293">
        <property type="entry name" value="BE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040042">
        <property type="entry name" value="Branching_enz_MT3115-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41695">
        <property type="entry name" value="PTHR41695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09210">
        <property type="entry name" value="DUF1957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="4">
        <location>
            <begin position="7"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1957" evidence="5">
        <location>
            <begin position="432"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT85134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="666" mass="78246" checksum="714542FE65CF665F" modified="2011-05-03" version="1">MAKGYFTFVLHTHIPYVRKHGKWPFGEEWIFEAIAESYIPLLMEFERLKKKGVKFQLVIGITPILAEQLADDYIKAEFEKYMERKLNAMREDLKKFENDEKLRKAVEYMLNYFEEVFEYWKKINGDIIGKFKQFQDGGYIEIITSAATHGYLPLLGRDEAIEGQLVNGILTYEKHFGRKPNGIWLPECAYRPEGFWQSPSSGEILWRKGLEKFLEKYNLKFFFVESHLIDEGPASFGYGKILPAKAPKSTLRPYFIKGTNIAVFARNRETGLQVWSADIGYPGDFWYREFHKKAEKSGGQYWRVTGKHIDLGDKEPYVPEKALERTEEHAKHFVSLVRGLLENYERETGEKGIVVAPYDTELFGHWWFEGVKWLGRVLELMSEEGIETTAISRFLESYRGERYEIELPEGSWGMYGTHYTWWNPEVEWMWEHIHKAEDRMVALVSKYLHEHEFGDRVLEQLGRELLLIESSDWPFLITTGQAKEYGKRRLLEHANVFHRLANALEEYFKSGEFREVEFLEEIEKKDNPFHPINIEVYVSEEPPSVPEYVEPPEIPKEKESSEEKTKVANEVVYSYTVIQRAYAMEKIKRKRIPKELPKLKRRKSKKKRNIQSELLKIKGIGSKTLKKLEKAGIRTLNDLKSADLEDLARRTKISVKRLKKFVSQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMC6</accession>
    <name>F0LMC6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-phosphooligosaccharide-protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Oligosaccharyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">TERMP_02175</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.21" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468445.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02175"/>
    <dbReference type="EnsemblBacteria" id="ADT85149">
        <property type="protein sequence ID" value="ADT85149"/>
        <property type="gene ID" value="TERMP_02175"/>
    </dbReference>
    <dbReference type="GeneID" id="10042490"/>
    <dbReference type="KEGG" id="tba:TERMP_02175"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2170"/>
    <dbReference type="eggNOG" id="arCOG02044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_346701_0_0_2"/>
    <dbReference type="OMA" id="FRFRDPY"/>
    <dbReference type="OrthoDB" id="2439at2157"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="PTHR13872"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PMT_2" evidence="17">
        <location>
            <begin position="67"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ADT85149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="813" mass="94563" checksum="5FB26AAF0C82F79F" modified="2011-05-03" version="1">MKKEKIYLILLLITSFILRLIPHRTLLLAVYDEYLHRDITLRIVNEGIGVISKDIGSLLGLKAYSYPPLFHIVGALVYRLFSTEYTFFILPAVYGTISVGLFYLLSKEIFRDNKKAILATTFLAFAPNFVYRTSLYIPENLGLVLFITGMILLVKFLKSWNYKYIIGLLVLLPIYMLTHRGWVFFVAVAVIMLFVYLIPWIKKNLHYFALAVLIALILYFIPPIHRFIASLLLRMPKEEVTALGYLKWIGVVQLIFGILATKKYIKSDPIRQGIALWAWTFMIAGAIAFRFRDPYASLPLSIMAAEFFYDDFLPSLNTWLNTVIKDTSGKGSELFKRIVLSKKTRAVIIAVLIIIPIVQGAYSSYKYIIPPTVKDREAFEWIRENTPPDAVFLTWWDVGYLLIGNTHRKDIVMWKKVYQGFFEKAPNPREAIQAYNDVVTMFGTTQRERTYKLMEKYNVTYVYSDRRMRSLGLIKYGLMEYIAYDTHFKTLFVNGNSEIYKFIPNPPLKPYDLNPLSYTGKYSAVVNFLEKFWTGFNYADFDDGYKADFFLNARIAQLYAYLYQKTGNEKFKERYQWLLKWLAYRQLDNGGFPEGIPPNDFTLYTAFTMEPLKDLPFEGKDKALIYLRNRVKGDYIMTTPKDKKGDLFAEAQMLPILYELRVLNETTTDNLVEKILKEQRKDGSWKKSLGGTIVTAFGLARYYQLSKDERVLPAIKKAAEWISEQQEENGRFKGEVGYGYSRATYANVLFIYHVAGMKDKEEQMLRIIEETYDLQKEPRPLQATLDILRALEYTYGLERALDILENILELHPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMC9</accession>
    <name>F0LMC9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyl-L,L-diaminopimelate deacetylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468448.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02178"/>
    <dbReference type="EnsemblBacteria" id="ADT85152">
        <property type="protein sequence ID" value="ADT85152"/>
        <property type="gene ID" value="TERMP_02178"/>
    </dbReference>
    <dbReference type="GeneID" id="10042493"/>
    <dbReference type="KEGG" id="tba:TERMP_02178"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2173"/>
    <dbReference type="eggNOG" id="arCOG01108">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_1_1_2"/>
    <dbReference type="OMA" id="RAHACGH"/>
    <dbReference type="OrthoDB" id="32735at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="177"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="385" mass="42704" checksum="17326113EDB8CC3E" modified="2011-05-03" version="1">MNPVEEALKIKDQIITWRRDFHMYPELKYEEERTSKIVEEHLREWGYKIKRVGTGIIADIGEGDKRIALRADMDALPVQEENDVSYKSRVPGKMHACGHDAHTAMLLGAAKIMAEYEDKLQNGVRLIFQPAEEGGNGALKMIEAGALEGVDAIFGIHVWMDLPSGVFGIREGPLLAGAGTFSIKIRGKGGHGAAPHETVDPIPLAAHAILAFQTIVSRNLNPIETGVVSVCAVQGGTAFNVIPEEVEMKGTHRFFSEEVRKLIEKRMDEILRGLTSAHGATYELDIKELVPPTINHPRMAEFVRRVALKYGMSVGEVAKSMGAEDFAYYLQKVPGMFIPLGIRNEKKGIVYPHHHPRFDVDEDVLYLGSALEVALAFEFLNLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMD8</accession>
    <name>F0LMD8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02187"/>
    <dbReference type="EnsemblBacteria" id="ADT85161">
        <property type="protein sequence ID" value="ADT85161"/>
        <property type="gene ID" value="TERMP_02187"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02187"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2182"/>
    <dbReference type="eggNOG" id="arCOG00131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051127_0_0_2"/>
    <dbReference type="OMA" id="FNEISGW"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="373" mass="41842" checksum="788FEC7119884798" modified="2011-05-03" version="1">MPLYLLQLGGNAQMVGIMNSLASLSSMIGSLFWGKLSDRTLRRKIFILFGFFSVSIFLTVLSFANSPAEFIILNAVYSFFLASTLSVPIVLVLRSVRKHSWDYGIGKFNEISGWAWVFGLGLGFVLSQYLTIRQLLLLFAILNIPSLIWGAKTIREIPIYVNRKSIRIFGNYVVEKIRYVPTFMLHINLRKPKFGKFYFASFLFWISVGMYFSQFPVLLAENGFERRYIYLAAILNSSVSAFMYLKVGLMLENRDKLKVLKEGIALRLIGIATILIGTFMLPYLLPLAFLSYFLAGYSWSFISISSTSIVGKLAGEREKGTAMGTFNLINSLGYIIGSFLSGFLVYAGGFTANFGASSLFALLSLLSLRKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMH9</accession>
    <name>F0LMH9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RBG1-like GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467256.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00982"/>
    <dbReference type="EnsemblBacteria" id="ADT83958">
        <property type="protein sequence ID" value="ADT83958"/>
        <property type="gene ID" value="TERMP_00982"/>
    </dbReference>
    <dbReference type="GeneID" id="26136431"/>
    <dbReference type="KEGG" id="tba:TERMP_00982"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.985"/>
    <dbReference type="eggNOG" id="arCOG00358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_1_2"/>
    <dbReference type="OMA" id="SAKHPGQ"/>
    <dbReference type="OrthoDB" id="21317at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="PTHR43127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="82"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="312"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="387" mass="43193" checksum="FFB8A69BAF10F1B5" modified="2011-05-03" version="1">MPTNVTAEYLAAEEEYRNAKTIAEKIKALEKMYATVPKHKGTEKLRLQIKRRLAELRKELEKQQAQRKGGGYSFSVKKEGAAQIVLAGLPNVGKSSLLRRLTGVDTDVADYPFTTVEPIPGMMKHNDVQIQLVEVPGLVEGASLGKGMGTQLLAVIRNADAIAIVIDLSQDPIRQMEIILKEFERAGIKINKRKPRIEIKKMPYGGIVINGQENIKGDIEEVMKMLREEKIHSAEITVKEPVTLEEFADALDESLVWRRAIIIANKGDAPGSRENYEKLVREYGNRFKIVPVSAKKGINIDVVKDALYELAGIIRVFTKSPGEEPAYPPIALRKGATVLDVAKRIHKDFAKKFKYARVWGKSVKFPGQRVGADHVLEDGDIVEIHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LML3</accession>
    <name>F0LML3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitro_FeMo-Co domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01016"/>
    <dbReference type="EnsemblBacteria" id="ADT83992">
        <property type="protein sequence ID" value="ADT83992"/>
        <property type="gene ID" value="TERMP_01016"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01016"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1019"/>
    <dbReference type="eggNOG" id="arCOG02734">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104194_0_1_2"/>
    <dbReference type="OMA" id="RLGYCPW"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00851">
        <property type="entry name" value="MTH1175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033913">
        <property type="entry name" value="MTH1175_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="1">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="196" mass="21117" checksum="9F9F919B269655B2" modified="2011-05-03" version="1">MHKIENWEVVSMVSMKIAVPSSANGGLEDTIAPVFARAPVFTIIEVENDEIKNVKTIQNPAVSAPSGAGPMAVQMLINEGVDAVIVPQLGPNALGAIQAAGIKVYTFPPGIPIREAVESVIKGALQTVQPPYPVPSALTYGPAYPIPAYGFGYGWGRGRGWSRGGWRGRGWGARLGYCPWTGMPSRRALRWLYGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMQ6</accession>
    <name>F0LMQ6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467333.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01059"/>
    <dbReference type="EnsemblBacteria" id="ADT84035">
        <property type="protein sequence ID" value="ADT84035"/>
        <property type="gene ID" value="TERMP_01059"/>
    </dbReference>
    <dbReference type="GeneID" id="26136510"/>
    <dbReference type="KEGG" id="tba:TERMP_01059"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1062"/>
    <dbReference type="eggNOG" id="arCOG01710">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128233_0_0_2"/>
    <dbReference type="OMA" id="VYTGLHQ"/>
    <dbReference type="OrthoDB" id="89832at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="143" mass="15570" checksum="D73F264BC276864B" modified="2011-05-03" version="1">MVERSKVRVLIAKPGLDGHDRGAKVIARALRDAGFEVIYTGIRQTPEQIVESVIQEDVDVLGISILSGAHMVLIPKILRLLEEKGLKPNEDILVIAGGIIPPDDAQELEKMGVAKVFGPGSPINEIVNFIDENVPKLKKFRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMT4</accession>
    <name>F0LMT4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467361.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01087"/>
    <dbReference type="EnsemblBacteria" id="ADT84063">
        <property type="protein sequence ID" value="ADT84063"/>
        <property type="gene ID" value="TERMP_01087"/>
    </dbReference>
    <dbReference type="GeneID" id="10041404"/>
    <dbReference type="KEGG" id="tba:TERMP_01087"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1090"/>
    <dbReference type="eggNOG" id="arCOG06986">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1163851_0_0_2"/>
    <dbReference type="OrthoDB" id="77672at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="238" mass="27082" checksum="0E1CA97A6E956BA4" modified="2011-05-03" version="1">MLKLLKGFSSKIETEENLIILPKEEKAEFGTFLCSSTIIMGKHMRGTYHEGLVFSTSRRFEKEGKITVKELLLEPKECRVEVDVSGVGALKLPGFRLENGILILYILPKYIFEFSHENLTLATQEDYAQITFFPLEYGFGGEVSLSLNKAKEVRVLLRGNKAEEFLFWDHEDGSFAYNFIDESLVIISHEKFITPKEFARSLGRVSIISGHGEFEIVGEMVLSLKKEVRESIKLAVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMW8</accession>
    <name>F0LMW8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467395.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01121"/>
    <dbReference type="EnsemblBacteria" id="ADT84097">
        <property type="protein sequence ID" value="ADT84097"/>
        <property type="gene ID" value="TERMP_01121"/>
    </dbReference>
    <dbReference type="GeneID" id="10041438"/>
    <dbReference type="KEGG" id="tba:TERMP_01121"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1124"/>
    <dbReference type="HOGENOM" id="CLU_1014184_0_0_2"/>
    <dbReference type="OrthoDB" id="136637at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="274" mass="30832" checksum="B722C5AE8198F564" modified="2011-05-03" version="1">MKQKIVWFIFGILLGSMFLVYADSGFRNNSCKCSTNIEELHASGTLNYTIKGPYNLTPREVMLSLPLEGAKILNKKIQGAKHIATFPVKGAYYSIFQKSSNPLTDSFYVIWDKNGIKEIDKLKFKILEEKTETKASGKETFYYIKAQVSNVEALSTVYVITAEYTYTWSIGDAVWSKTVAKGTFWVDYGNKILSVNDLSYEYHPWGVIKCSFSSHTSGVGTVSAGVYADASYMFWDLLSPVAAHWDAHSRVFVDAWTNINGYGWGNKWIGGPWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN00</accession>
    <name>F0LN00_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carbon monoxide dehydrogenase</fullName>
            <ecNumber evidence="10">1.2.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TERMP_01153</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:21040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[Ni-Fe-S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60400"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Ni-containing carbon monoxide dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.4" evidence="10"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01153"/>
    <dbReference type="EnsemblBacteria" id="ADT84129">
        <property type="protein sequence ID" value="ADT84129"/>
        <property type="gene ID" value="TERMP_01153"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01153"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1156"/>
    <dbReference type="eggNOG" id="arCOG02429">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030631_0_0_2"/>
    <dbReference type="OMA" id="MCCTGNE"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018492">
        <property type="term" value="F:carbon-monoxide dehydrogenase (acceptor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043885">
        <property type="term" value="F:carbon-monoxide dehydrogenase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01915">
        <property type="entry name" value="CODH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016101">
        <property type="entry name" value="CO_DH_a-bundle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010047">
        <property type="entry name" value="CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004137">
        <property type="entry name" value="HCP/CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109">
        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005023">
        <property type="entry name" value="CODH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01702">
        <property type="entry name" value="CO_DH_cata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
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        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="77"/>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005023-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT84129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="633" mass="68199" checksum="9DB62E29BF16D180" modified="2011-05-03" version="1">MAEYIKFKVPAKQVSETKGVGNLIEKAEEEGVKTAWHRFLEQQPQCGFGLLGICCRNCNMGPCRIDPFGAGPTKGVCGADADTIVARNILRMIAAGAAAHSDHARDIVHVFKGAATGEFKGYRLTDVEKLKGLAQILGIDIEGKSESEIASEVAHILELEFGKPDDEPLKLLMATAPKKRIKVWERLGVMPRAIDREICECMHRTHMGVDADPASLLLHGVRTSLADGWSGSMMATYLSDILFGTPKPIKTTANLGVLKEDYVNIIVHGHNPILSMKIAEVAQSEEMQKLAKKYGAKGVNVAGMCCTGNEVLVRLGIPPAGNFLMQELAIITGAVEAMVVDYQCLMPSLVDVAGCYHTKIITTEPKAHIPGAVHIEFKPEKADEIAKEIVKIAIENFQNRPKERVFIPKHKSEVVAGFSVEAILEALGGTLEPLINALREGTIKGIVGVVGCNNPKVKHNHSHVTLTKELIKRDILVVGTGCWGIAAAMHGLLTPEAAKMAGEGLRAVCETLGIPPCLHMGSCVDCSRILIVLGALAEALGVDIPDLPVAGSAPEWMSEKAVSIGTYFVASGVFTHLGVVPPVLGSQKVTRLLTDEIEDLLGGKFYVEPDPVKAAETIYNVIIEKRKKLKWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN37</accession>
    <name>F0LN37_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ferric iron ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467464.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01190"/>
    <dbReference type="EnsemblBacteria" id="ADT84166">
        <property type="protein sequence ID" value="ADT84166"/>
        <property type="gene ID" value="TERMP_01190"/>
    </dbReference>
    <dbReference type="GeneID" id="10041507"/>
    <dbReference type="KEGG" id="tba:TERMP_01190"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1193"/>
    <dbReference type="eggNOG" id="arCOG00163">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_1_0_2"/>
    <dbReference type="OMA" id="QAFWRVA"/>
    <dbReference type="OrthoDB" id="32131at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="99"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="396"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="613" mass="67960" checksum="FDE4B052FC47A5EA" modified="2011-05-03" version="1">MRVSKWSEKLFGTPLFEPLVSFSYLFPLLYIVVFLIIPVLAMLAIAFSHEGHFSLYWFKSILTSSYYVQFPPQGDFAIKTVTATGETVYLIRGIDFGVVINSLVVAALVTLLASLMGTIFAFIMARYEFKGKNFFRIALFIPLLVTPFVNAYVIKKMFLDTGLINYIFYELLHILPFRIKIDGLAGVVLAQAMTYYPIVYLNAYASFINIDPTLEEQAENLGSRGFHLFRTVTFPLALPGIAAGATLVFIFSLEDLAAPIVFQGDPLAKKLMSYQIFSKFLYGLGERSPEIAALSIIMLTLAVLAFLGIRKYVSLRQYAMLSKGGRWKPRVSKPKPWQAAIIYVVLLPLLLLTIFPQIGVVLLAFSKQWSVTVMPQGFTTEYVKQMLFNPDVRRYIINSLMYSGAAVVLIVLLSVTSSYATSRFKGILTPVLESLVIIPIAVPGIVVAMGYFYFFSQVFPNTPLDPTNIFSFNPAFVLILAYSIRRLPFSARSVYAGLQQVHVSLEEASMNLGASRWKTVTGILLPLISLNVFGGAMLSFVYSMSETSVGITLGSLNMQYAPITAFMKDIMMSAAGSAQLAAALGVLLITVQILSIVLVNIITKQRYAFIGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN57</accession>
    <name>F0LN57_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02223"/>
    <dbReference type="EnsemblBacteria" id="ADT85196">
        <property type="protein sequence ID" value="ADT85196"/>
        <property type="gene ID" value="TERMP_02223"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02223"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2217"/>
    <dbReference type="HOGENOM" id="CLU_2893446_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="62" mass="7139" checksum="CA87F94B5A4288D4" modified="2011-05-03" version="1">MEDRFEELARAVLGKRVVRVVTGPDGFDLEFDDGTIIELYDVGGYVITSRKEVEKYEKLNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN66</accession>
    <name>F0LN66_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02232"/>
    <dbReference type="REBASE" id="29892">
        <property type="entry name" value="TbaMPMcrBP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT85205">
        <property type="protein sequence ID" value="ADT85205"/>
        <property type="gene ID" value="TERMP_02232"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02232"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2226"/>
    <dbReference type="eggNOG" id="arCOG00441">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07794">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011498_5_0_2"/>
    <dbReference type="OrthoDB" id="33821at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="958" mass="111518" checksum="AACA2F1622AAD1AA" modified="2011-05-03" version="1">MSRRIDEILDVLKEIKDMYSPEQDLEKLRKEATERVAKRHGVEINTVSDKYTRQLGLNVAGFDELLKEWIINNNPQPLMQRLLKYAVDNRDKKRIHEFFGDSNSEKQIETKTIGIVANIAWAHNRWKGFDEEGFKKRDKYGFEYVKQTGLAHEWWNFYENFSPEYYYGHVESRGKLGKFSEGLVIFISRNIDDGKFYLVGFYGKGEYSREGFRTGKALTEILPDEAKEYLNEAIKKGDISEKHAEYIAKVLSGEVNEVVSKLRGKKTLSTVFLPEAYVKFSPEEIGLKKFGQNKIVYIGENEIIKPESVYNLLLKAKQQHEELLNNPELPDEKRQEAEDIIKKIEWVLEEYFEGEFMGKDDSDSKNIKNLKQYFHSKGYHFPDHVIAQFYTALKTKGFVILSGLSGTGKTKIALEFAELLEDRLAGDKIPQLMVASGPNTKAEEEIKAIEKTIEEIGYVIYAWRPAGKAKDIDLPFILWVYDSDEKDTQYYRKVPYGLFIVDRILKEEKELPESWKKGMKWVKRVYDETVEDYIKEHDIFLKAIKVIECDRSVSQFWDVEKERPARSSDMSGGGFIKVKAPKDCMPKISNHIFLSVRPDWRDSKPLLGYYNPLDGKYYKTPLLEFILRAIKDYEQNREKAMPYFIILDEMNLAHVEYYFADFLSVLESGRDDSGFTRESIKLHDVDKVVEEQGIPKELKLPPNLYIIGTVNIDETTYMFSPKVLDRAFTIEFHDVDLEGYPPEEAKLSQEELENLRKRVLDDLRRSGKFLTVYKKGKDGLAKSDIEEALKELKNAGNGKYWQILQQLNKTLEPYDLHFGYRVVDEIALFFENAKESWKARIIEFENNNDENKVNNEIFDLALLMKILPKFHGNRKKLEKPLLLVLKLAKKGMLDEKDADKDVDELFKEVFETENIQNKSDVVVKVLANSTSNYTLQHTAKKVLRMLRQLYEIGFASFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN82</accession>
    <name>F0LN82_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NPCBM_assoc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
            <plasmid evidence="3 4">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747443.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02248"/>
    <dbReference type="EnsemblBacteria" id="ADT85221">
        <property type="protein sequence ID" value="ADT85221"/>
        <property type="gene ID" value="TERMP_02248"/>
    </dbReference>
    <dbReference type="GeneID" id="10549072"/>
    <dbReference type="KEGG" id="tba:TERMP_02248"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2242"/>
    <dbReference type="eggNOG" id="arCOG02087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024113_0_0_2"/>
    <dbReference type="OMA" id="TSERAYS"/>
    <dbReference type="OrthoDB" id="15690at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM_assoc" evidence="2">
        <location>
            <begin position="535"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="644" mass="74090" checksum="E4A01C2FE1847BEA" modified="2011-05-03" version="1">MKRGILIFLIFLSALPSLQALQGEPIFNGHLTTYDAIGVGNFTIQLQLSLSGEPYLMVTNKTQIVWFGKAIFGKQIEFGNFTLIIGKWANERLHVLIYGPDTKVQKVQRAEKFRVRYQPLVVEATPRTTLKLPIEIENPTMDNLTLTFDLVDVPNTWKAHFETSERAYSLKQLLLGPEKNIRLYLIVDIPANARTDKVRFRINSFVGEIKIEFPDKEHKENTTITIPYSQLRVSCDERAEFPIIVENYGEETFAIFRVLEKPQNWNVDFYDSENQKTRVLFLKPNEKKVVYLVAEKPYTGPNEGKIKVLINGNRYQFNVSFLGECRTQHISVKIRVFNEDLVPIKYPIVKFGNLTKIGDSEGRVEFELNPGTYTMTLAAKGYRNKTINLSLSLAENRELDVILEKEPSKVELSFETLDVELNEEYTTVKFILKNLGYEEREIMFDLSGPENIRWWVLKSPTSEKALSILKLGPNEISVLYLKLKAKDMHSGTYNLTFRVLTTENITEKVLRLHVLENPKIKIILDSYYYETQDKITIPVKVRNAGNTKLENLSLVAEVPEGWSYEVSQSNFALEPGETQEIEIKIKTDRREGEYSVQVCVLNEVKETCDFVIIRVTKPDSLIYAFSWIISVIGVILIGNLRKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGU5</accession>
    <name>F0LGU5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oligopeptide transport ATP-binding protein OppF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00006"/>
    <dbReference type="EnsemblBacteria" id="ADT82984">
        <property type="protein sequence ID" value="ADT82984"/>
        <property type="gene ID" value="TERMP_00006"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00006"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.6"/>
    <dbReference type="eggNOG" id="arCOG00184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="FEINERK"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="oligo_HPY" evidence="4">
        <location>
            <begin position="55"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT82984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="146" mass="16023" checksum="B03188CB264AA7F1" modified="2011-05-03" version="1">MIDVSLRIGILDLLLKLKEEVGTSYLFITHDFGAARYFSAKGGGSIAVMYLGKIVEVAAAEEVIQNPLHPYTKALISSVPVADPELSRKRKPLKLKSLDIPSPLNPPSGCKFHTRCPYSKDICSKVEPELKEVSPGHYVACHLYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGZ7</accession>
    <name>F0LGZ7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467503.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01229"/>
    <dbReference type="EnsemblBacteria" id="ADT84205">
        <property type="protein sequence ID" value="ADT84205"/>
        <property type="gene ID" value="TERMP_01229"/>
    </dbReference>
    <dbReference type="GeneID" id="10041546"/>
    <dbReference type="KEGG" id="tba:TERMP_01229"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1230"/>
    <dbReference type="eggNOG" id="arCOG01019">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140136_0_0_2"/>
    <dbReference type="OMA" id="LFKLAFK"/>
    <dbReference type="OrthoDB" id="90556at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018665">
        <property type="entry name" value="DUF2122_RecB-nuclease-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09895">
        <property type="entry name" value="DUF2122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="143" mass="16114" checksum="11EDCB9A1F2DF7BD" modified="2011-05-03" version="1">MIIVVYHNINATRKLEEFAKIAFGFDVDLLVISKPTGTAAQMGVPEIHKEAFKRGKNVLIVGDLPDAIEVVQPDKIYTITKFGKPTNWEELREKLKEKKVMFIFGGTEPGLGKKEIEMGTPINIKWEIGELGELAILLHELKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH04</accession>
    <name>F0LH04_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01236"/>
    <dbReference type="EnsemblBacteria" id="ADT84212">
        <property type="protein sequence ID" value="ADT84212"/>
        <property type="gene ID" value="TERMP_01236"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01236"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1238"/>
    <dbReference type="eggNOG" id="arCOG00139">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2010205_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="123" mass="14101" checksum="F0DE8A771B2D386E" modified="2011-05-03" version="1">MRWSEVPRDAKAYMLYHTIIAPQLIVWYLLPLYMMYSGYSVLEVGAFFTAVNIVSIPLTYLIGRFFNEYPLKTGLILIDALDGIAYILYGFAKGSIAPLMLFLGYTIEEISALFYPFTKLMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH06</accession>
    <name>F0LH06_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467512.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01238"/>
    <dbReference type="EnsemblBacteria" id="ADT84214">
        <property type="protein sequence ID" value="ADT84214"/>
        <property type="gene ID" value="TERMP_01238"/>
    </dbReference>
    <dbReference type="GeneID" id="26136714"/>
    <dbReference type="KEGG" id="tba:TERMP_01238"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1240"/>
    <dbReference type="eggNOG" id="arCOG01679">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_9_1_2"/>
    <dbReference type="OMA" id="YRAVPFE"/>
    <dbReference type="OrthoDB" id="119169at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="97" mass="10957" checksum="E1AEF35ADC55E777" modified="2011-05-03" version="1">MNAEKLAKMLDGLGHPLRLKIVALLARENRVMYLNEIANSLGISRALAKVHLKKLEKAGIVKSKIILDEEKGKALRFYELVPFEIHISPEILKEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH14</accession>
    <name>F0LH14_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84222">
        <property type="protein sequence ID" value="ADT84222"/>
        <property type="gene ID" value="TERMP_01246"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01246"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1248"/>
    <dbReference type="eggNOG" id="arCOG06877">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2629902_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="77" mass="9477" checksum="C6C445F711C5CCC0" modified="2011-05-03" version="1">MIDWIKVEIMGDIQKKVYDEWEPPVDINRYKRFVQIEGMKIPVLDLEYEYQAYLKLGRIEKARMLKKFFRKKIRASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH58</accession>
    <name>F0LH58_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466318.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00042"/>
    <dbReference type="EnsemblBacteria" id="ADT83020">
        <property type="protein sequence ID" value="ADT83020"/>
        <property type="gene ID" value="TERMP_00042"/>
    </dbReference>
    <dbReference type="GeneID" id="10040361"/>
    <dbReference type="KEGG" id="tba:TERMP_00042"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.43"/>
    <dbReference type="eggNOG" id="arCOG00243">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032858_3_0_2"/>
    <dbReference type="OMA" id="PCEAIVD"/>
    <dbReference type="OrthoDB" id="71470at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Sacchrp_dh_C" evidence="2">
        <location>
            <begin position="117"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="354" mass="40372" checksum="3E1EC6223DFB96D6" modified="2011-05-03" version="1">MKVLVLGAGNVGRAIAYDLSRDFEVWVGDKNKEHLDKVRDFANTIKIDASDFDRLVDIMKKFEIIVGALPGKLGFTTLKAAIKAQRDLVDISFMPEDPMELRDDAENAQITAIVDAGFAPGLSNILMGRIYQEIDELKEGIIRVGGLPKKAKPPLYYKITWSPYDLIEEYTRKARIIKNGQIAEVDPLEKIEKIKIKGFEFEEFVSDGLRTLLENIRAEHLEERTLRWPGHLEKIKVLRELGFFKPENIEFTLKVIAPLMQYESDDFSIMEVYGRGTSNGKTKEIHYFLYDEAKEGFTSMARVTGFTAAVITRLLAEGSCVYGVIPPEILGMRSDIFTRIIDELKERDIIIERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH61</accession>
    <name>F0LH61_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466321.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00045"/>
    <dbReference type="EnsemblBacteria" id="ADT83023">
        <property type="protein sequence ID" value="ADT83023"/>
        <property type="gene ID" value="TERMP_00045"/>
    </dbReference>
    <dbReference type="GeneID" id="25394623"/>
    <dbReference type="KEGG" id="tba:TERMP_00045"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.46"/>
    <dbReference type="eggNOG" id="arCOG03792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102063_0_0_2"/>
    <dbReference type="OMA" id="FINRDIA"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005489">
        <property type="entry name" value="DUF257"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03192">
        <property type="entry name" value="DUF257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="225" mass="25891" checksum="D4F242BF6BBF3178" modified="2011-05-03" version="1">MTDGRALIEYLGSIKFGESVLVEYSPEAPIPIIFRETIEFLLKKYNVLILDIFDTLHMIKEPLKIMGWDAEKLDKIDVVKAGGIINTGNIVKRIDISKDPAVYTLEFAEFMREYYATHRPTVLIALGIDKLIRLYTNEVTSFEIHIAGVMKKFLGERSRLSLYFANMALVPKETLYEWEEIVTRVFEITLKGKMKFVIKVKKSPNIEDHEKEFVISADELPLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH64</accession>
    <name>F0LH64_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="3">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_00048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466324.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00048"/>
    <dbReference type="EnsemblBacteria" id="ADT83026">
        <property type="protein sequence ID" value="ADT83026"/>
        <property type="gene ID" value="TERMP_00048"/>
    </dbReference>
    <dbReference type="GeneID" id="10040367"/>
    <dbReference type="KEGG" id="tba:TERMP_00048"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.49"/>
    <dbReference type="eggNOG" id="arCOG00912">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_2_2"/>
    <dbReference type="OMA" id="DGNNVCN"/>
    <dbReference type="OrthoDB" id="43727at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="154"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="270"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="315" mass="35148" checksum="D995F72AF85956F3" modified="2011-05-03" version="1">MVVSLAGRDILCLQDFTREEIETILETAKMMKIWNKIGKPHRVLEGKTLAMIFQKPSTRTRISFEVGMYQLGGYALYLNAQDLQLRRGETIADTARVLSRYVDGIMARVYAHKDVEDLAKYASVPVINGLSDFSHPCQALADYMTIWEKKGRIQGIKVVYVGDGNNVAHSLMIAGTKLGADVVVATPEGYEPNEKVIKWAEKNAAESGGSFELLHDPVNAVKDADVIYTDVWASMGQEAEAEMRRKIFKPFQVNKELVKHAKPDYIFMHCLPAHRGEEVTDDVIDSPNSVVWDQAENRLHAQKAALALVMGGIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHA6</accession>
    <name>F0LHA6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466366.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00090"/>
    <dbReference type="EnsemblBacteria" id="ADT83068">
        <property type="protein sequence ID" value="ADT83068"/>
        <property type="gene ID" value="TERMP_00090"/>
    </dbReference>
    <dbReference type="GeneID" id="26135406"/>
    <dbReference type="KEGG" id="tba:TERMP_00090"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.91"/>
    <dbReference type="eggNOG" id="arCOG04069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017233_1_0_2"/>
    <dbReference type="OMA" id="FPIHKDL"/>
    <dbReference type="OrthoDB" id="58391at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="PTHR12150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="258" mass="29197" checksum="5AD72D632C356A8C" modified="2011-05-03" version="1">MTLHIFIPDSLLEETADPKIRTYKVGQIARAAAIFGVEHIWIYKAGGKDGKFIKLILEYAETPQYLRKTLFPIRKELKYVGVIPPLRTPHHKLKGRPKLGEIREGVIIKKGKRLYADIGLDELALVEGSGEGRMTFKIVSVNPLKVVPAKPAEYWGYRVHLTNKPLAKTLKKARLDLAIATSRKGEDVRKVKLPPLEGDIGFVFGSPRKGVMEILRDFNEDYPFDLILNTIPNQKTKTVRTEEAVLATLAVFNFIRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHB0</accession>
    <name>F0LHB0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl2</name>
        <name evidence="7" type="ordered locus">TERMP_00094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466370.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00094"/>
    <dbReference type="EnsemblBacteria" id="ADT83072">
        <property type="protein sequence ID" value="ADT83072"/>
        <property type="gene ID" value="TERMP_00094"/>
    </dbReference>
    <dbReference type="GeneID" id="26135410"/>
    <dbReference type="KEGG" id="tba:TERMP_00094"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.95"/>
    <dbReference type="eggNOG" id="arCOG04067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_0_1_2"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="OrthoDB" id="74812at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_A">
        <property type="entry name" value="Ribosomal_L2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_L2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="91"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="239" mass="25963" checksum="3C317A4BDBC1980D" modified="2011-05-03" version="1">MGKSLIQQRRGKGSPTFRAPSHRYRGAVRYIPLNLTKEKTIVGKVVEILHDPGRTAPVARVKFENGLEKLIIAPEGLLVGDEIAIGPNAPIKIGNTLPLAMIPEGTYIYDIEAVPGDGGKFVRAGGSYALVVSREKDKVIVQLPSGELKAFNPMCRATIGVVAGGGRLEKPLVKAGKAYYVMKARNRFWPKPRGVKMNAVNHPHGGKEHHIGRPSTVSRRAPPGRKVGHIAARRTGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHC3</accession>
    <name>F0LHC3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps8</name>
        <name evidence="6" type="ordered locus">TERMP_00107</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466383.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00107"/>
    <dbReference type="EnsemblBacteria" id="ADT83085">
        <property type="protein sequence ID" value="ADT83085"/>
        <property type="gene ID" value="TERMP_00107"/>
    </dbReference>
    <dbReference type="GeneID" id="26135423"/>
    <dbReference type="KEGG" id="tba:TERMP_00107"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.108"/>
    <dbReference type="eggNOG" id="arCOG04091">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_1_1_2"/>
    <dbReference type="OMA" id="LPAKNFG"/>
    <dbReference type="OrthoDB" id="91154at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_A">
        <property type="entry name" value="Ribosomal_S8_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="130" mass="14693" checksum="D8E5521317046270" modified="2011-05-03" version="1">MTLLDPLANALSHITNSEKVGKKEVYIKPASKLIGEVLRVMQENGYIGEFEFIDDGRAGIYRVQLIGKINKAGAIKPRFPVKARDYEYWEKRFLPAFEFGILIVSTSQGVMTHKEARDRGIGGRLIAYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHF3</accession>
    <name>F0LHF3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467578.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01305"/>
    <dbReference type="EnsemblBacteria" id="ADT84280">
        <property type="protein sequence ID" value="ADT84280"/>
        <property type="gene ID" value="TERMP_01305"/>
    </dbReference>
    <dbReference type="GeneID" id="26136784"/>
    <dbReference type="KEGG" id="tba:TERMP_01305"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1306"/>
    <dbReference type="eggNOG" id="arCOG01907">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040551_4_1_2"/>
    <dbReference type="OMA" id="ICQKDAF"/>
    <dbReference type="OrthoDB" id="90481at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00266">
        <property type="entry name" value="TIGR00266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="222" mass="24278" checksum="A3274E2FAF42794F" modified="2011-05-03" version="1">MRYEIKHRPSFSLVEVELERGEAVQAEAGAMVFMSPSIKIETKAKGGIFGALKRSLLAGESFFINIFKAERDGGKVGFAPPYPGDIEAFEIDGTLYAQSGAFLASSADIKIDTKWGGAKTFFAREGLFLLKMSGRGVVFLSSYGAIQKVELNNEHFIIDTGHLVAFSEGLDFRVKRVGGLKSTFLSGEGLVAEFYGTGTLYIQTRSLDSFLSWIIPHLPTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHL5</accession>
    <name>F0LHL5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466397.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00121"/>
    <dbReference type="EnsemblBacteria" id="ADT83099">
        <property type="protein sequence ID" value="ADT83099"/>
        <property type="gene ID" value="TERMP_00121"/>
    </dbReference>
    <dbReference type="GeneID" id="10040440"/>
    <dbReference type="KEGG" id="tba:TERMP_00121"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.122"/>
    <dbReference type="eggNOG" id="arCOG01263">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_2"/>
    <dbReference type="OMA" id="MGTDNIP"/>
    <dbReference type="OrthoDB" id="38707at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="234" mass="26156" checksum="0DEB0D467588F24C" modified="2011-05-03" version="1">MKNALVTGASGGIGKLIVKKLIEEGYFVIGVGRNEKALRELSTLENFDYIIMDLSEKEAAKRIRKALEQRSIGRLDLLINNAGFAIAKPLLEQDEDELERLFRVNAIAPIALTKELLDMIPKGGKVVFVISGVAFINSVDLPAYGASKAALHYLAMNLEKELKNRGISAIRIYPKQVATPFWKRVPKGAIPAEKVADAIIEAIHKNKSEVFVPFYIRMAKYFPGWPAFDYKFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHQ5</accession>
    <name>F0LHQ5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exosome complex component Rrp4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rrp4</name>
        <name evidence="5" type="ordered locus">TERMP_00162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466437.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00162"/>
    <dbReference type="EnsemblBacteria" id="ADT83139">
        <property type="protein sequence ID" value="ADT83139"/>
        <property type="gene ID" value="TERMP_00162"/>
    </dbReference>
    <dbReference type="GeneID" id="26135491"/>
    <dbReference type="KEGG" id="tba:TERMP_00162"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.163"/>
    <dbReference type="eggNOG" id="arCOG00678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071769_0_0_2"/>
    <dbReference type="OMA" id="GPYIPEV"/>
    <dbReference type="OrthoDB" id="93052at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00623">
        <property type="entry name" value="Exosome_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023474">
        <property type="entry name" value="Rrp4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PTHR21321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="65"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="255" mass="28371" checksum="2B0C051A537FDCC2" modified="2011-05-03" version="1">MRRVFVQNRELVVPGTLLAQGPFKNGRGTFKEGNRIYSTVVGLVDIRNDFIRVIPLEGPYIPEVGDNVIGKIVDVKFSSWTVDIGAPYQATLRIQDAVEEKIDLLKTDLRKIFDIGDIIYAKVKAFNEVNQIDLTTKGMPFNGGPLKGGQIVKITPSKVPRLIGKGGSMINLIKKMTQTRIIVGQNGWVWVSGRKEELERVAIEAILKVDRESHTQGLTDRVKELLLTRLKELKEQGIIGEIPQIEEGEGNDGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHR7</accession>
    <name>F0LHR7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466449.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00174"/>
    <dbReference type="EnsemblBacteria" id="ADT83151">
        <property type="protein sequence ID" value="ADT83151"/>
        <property type="gene ID" value="TERMP_00174"/>
    </dbReference>
    <dbReference type="GeneID" id="10040492"/>
    <dbReference type="KEGG" id="tba:TERMP_00174"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.175"/>
    <dbReference type="eggNOG" id="arCOG05853">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2152743_0_0_2"/>
    <dbReference type="OMA" id="HCGEEFY"/>
    <dbReference type="OrthoDB" id="102884at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="108" mass="12830" checksum="CDEEDF4FC7E4D71A" modified="2011-05-03" version="1">MARCPICGEALKWEELIEQMLTLENFSELLTDKGAFISAFEEFIFMCPHCKEEFYGRHLEMKEAEKVFELLNDFKGGIDYENKKVKLKLTNLLALDMMLEEWDKRVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHS8</accession>
    <name>F0LHS8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAP-like transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466460.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00185"/>
    <dbReference type="EnsemblBacteria" id="ADT83162">
        <property type="protein sequence ID" value="ADT83162"/>
        <property type="gene ID" value="TERMP_00185"/>
    </dbReference>
    <dbReference type="GeneID" id="10040503"/>
    <dbReference type="KEGG" id="tba:TERMP_00185"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.186"/>
    <dbReference type="eggNOG" id="arCOG01906">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007041_3_1_2"/>
    <dbReference type="OMA" id="QWITTEG"/>
    <dbReference type="OrthoDB" id="3452at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011853">
        <property type="entry name" value="TRAP_DctM-Dct_fused"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02123">
        <property type="entry name" value="TRAP_fused"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="731"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="2">
        <location>
            <begin position="142"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="2">
        <location>
            <begin position="461"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="763" mass="83939" checksum="5E6248BED2BF0095" modified="2011-05-03" version="1">MGENLEKIEKKIALEKTRTLPPKLENVVKAAAILIGIFEILFIFNFTFTVYSLFDRLGIRIEILKLDFQDQQVMAFVLGMIFVIAFLRYPIIKKDKYLKKVQLIDYILILLGLAAALYKFWRWPTYMVYYDVNQTDVIFGFLAIILVLEATRRAIGWILPTIVTVFLLYGIKDAGFNWTRIAQYLYLDQGIFGIPFYVMTIYVFAFVFFGAFLLKIGVSDYITEFMISIFGPRPGGPAKAAVISSGMMGTVSGSSVANVLTTGTFTIPLMKKAGYPPEIAGAVEPVASTGGQLMPPVMGAAAFIMAQFLGVPYNKLIIAAVLPALIYYSGVYLFIDLETKRLGLKGMPREHFKPIRYFLRKLYILLPILVITVALVWGIAPHIAAVSSLGIAIWVAWVSKDEIPGHEPLYVATVLITTLLMFTGRQHAKPVGIILLIIGLALIIMAITTDKVEFNEKFYISMLFIFLVALGKFLYMRKEEILLMSGVFGIIFSLIVGYKSKTEGGKAMYSATYESMISAGKTSTTVMLAAASAGLIQGVLTMTGLVTSLGYRLVDLAGGNLLLLLMMAMIFSLILGMGVPTTANYVITSLVAAPAVFNAVANNPIYSASVPGYATPIALLAAHFFVFYFGILADLTPPVALAAYAGSALAGGDFWKTATNSVKYALAGYIGPYIYFTHPEMFLITVQQWTPEVALRVLYYFIATILIMYLLSIAITGYYKKPIRKELRVIFGALGLVGATLHPIPIALVVLSIMGVILYARKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHU0</accession>
    <name>F0LHU0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467638.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01365"/>
    <dbReference type="EnsemblBacteria" id="ADT84340">
        <property type="protein sequence ID" value="ADT84340"/>
        <property type="gene ID" value="TERMP_01365"/>
    </dbReference>
    <dbReference type="GeneID" id="10041681"/>
    <dbReference type="KEGG" id="tba:TERMP_01365"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1365"/>
    <dbReference type="eggNOG" id="arCOG00585">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_2_2"/>
    <dbReference type="OMA" id="TRWDELD"/>
    <dbReference type="OrthoDB" id="93194at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="241" mass="27120" checksum="E1C132411249758C" modified="2011-05-03" version="1">MIDPRIKAIEARLEKVKRIIPVVSGKGGVGKSLISTTLALVLAEKGHKVGLLDLDFHGASDHVILGFEPKEFPEEDRGIVPPEIQGIKFMSIVFYSEDKPTPLRGHEISDALIELLAITRWEDLDFLIIDMPPGMGDQFLDVLRFLKRGEFLVVATPSKLAVNVVKKLLELLKEQNLKIIGIIENMKLNDEKDIQKLAEEFEVPYLVSIPLYRDLDTKIGNVEELLKSEFAEKIREAAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHU7</accession>
    <name>F0LHU7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467645.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01372"/>
    <dbReference type="EnsemblBacteria" id="ADT84347">
        <property type="protein sequence ID" value="ADT84347"/>
        <property type="gene ID" value="TERMP_01372"/>
    </dbReference>
    <dbReference type="GeneID" id="10041688"/>
    <dbReference type="KEGG" id="tba:TERMP_01372"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1372"/>
    <dbReference type="eggNOG" id="arCOG02559">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_525448_0_0_2"/>
    <dbReference type="OMA" id="YSVWPTS"/>
    <dbReference type="OrthoDB" id="89663at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027552">
        <property type="entry name" value="CGP_CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04288">
        <property type="entry name" value="CGP_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="518" mass="56381" checksum="DE1FB1C37A3C95FC" modified="2011-05-03" version="1">MKRIIVLFVALVLLPLSLAQEINYLTWGGSAYDIGVAFIPYNDSVFMIGSSDSFGSNRVGFVVKMTGDKFEFQKIIESSERLWVKKAVLWGENLYLVGQVGSTAFENSDAFIAKLDTDGDLEYFKTFGRSFNDEANDITFDNKYLYVVGYTKPTGKTKEGFVAKLTPGGDIVWFVQFGTGNTEAKAVTVSLDAVYVAGTDNDDVFVIKLSKEGELEWAKIWTTDEREDVGDIIFDGLLYVSGSTGESLAFGDGFLLKVSPDGSLINAMNFGLGYQDKIISVIPNNTELILVGNTGNFETRNKDTFIAKFTRDGKLLWFGKFIGAGSDLITSALMQDSVIYVAGYTESSSWEFVVPNVSEVTKKTLYGTLKISWSNYAPKVTKVALASQPHSVKVMQVEGILNSPHAGDAWFFTFGTKPKKEIQSLNTTTTATTIMTTTTTTPVPTKTTTTSSSATTTVTVTKTETTTATTTTITPSSTPITSSSPITTTSEKGGICGPASFLMLFVGTLLMKRRWENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHX9</accession>
    <name>F0LHX9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01404"/>
    <dbReference type="EnsemblBacteria" id="ADT84379">
        <property type="protein sequence ID" value="ADT84379"/>
        <property type="gene ID" value="TERMP_01404"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01404"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1404"/>
    <dbReference type="eggNOG" id="arCOG07698">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1709231_0_0_2"/>
    <dbReference type="OrthoDB" id="86576at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="174" mass="19781" checksum="9CC828037AC33324" modified="2011-05-03" version="1">MTQSTITTEVAEMVAPTPPPIKGDWKEYRKVFDPKLINKAIDVVKTALSLFTAGVPLIRRGPAGETHVDVPVMYMGVAIDRIHYDPYLKAPSPKGRPVRAWNVEIDPQEVRQTIEVVLKEAYVIEAAEFREPEDAWAIPVAWNRLIIMHVKVSYDGRELIPDYGLTEEVRRYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI34</accession>
    <name>F0LI34_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_00211</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466486.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00211"/>
    <dbReference type="EnsemblBacteria" id="ADT83188">
        <property type="protein sequence ID" value="ADT83188"/>
        <property type="gene ID" value="TERMP_00211"/>
    </dbReference>
    <dbReference type="GeneID" id="10040529"/>
    <dbReference type="KEGG" id="tba:TERMP_00211"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.211"/>
    <dbReference type="eggNOG" id="arCOG01421">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015112_0_0_2"/>
    <dbReference type="OMA" id="LYRHGYF"/>
    <dbReference type="OrthoDB" id="19755at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024517">
        <property type="entry name" value="Glycogen_phosphorylase_DUF3417"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11897">
        <property type="entry name" value="DUF3417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3417" evidence="10">
        <location>
            <begin position="11"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="833" mass="97454" checksum="05F6F68DEC7A5F06" modified="2011-05-03" version="1">MVVESTIKEKLPENIRGLAKLAYNYWWSWDHKATKMWMYIDEEHWREYKNPVKLLLDVDKERLKELARDEFFLDLYELVMSNFERYMSEKNTWFSINYPKWDKPIVYLCMEYGIGKSLPIYSGGLGILAGDHIKTASDLGLPLIAVGLLYKHGYFKQEIDENGRQIEEFPSYDPKEMPIKQILKENGEPLLISVPIEDREVYARVFEVNVGRIKLYLLDTDVEQNEEDDRRICDYLYNAELDKRIKQEILLGIGGMRLLKALKIEPGVIHLNEGHPAFANFERIVWYMEEGLSFEEALEVVRGTSVFTTHTPVPAGHDVFPVWFVEEKLGKFFEGLPKEKFLALGKVEEKDPNFNMSLLAIKTSNFINGVSKLHAEVTKKMWLNLWKGVPIDEIPIEGITNGIHTPTWVHEKLARLYDRYMGKVWREHVNLEGIWYAIERIPDKELWEAHLKAKRELIELIKRKIRERNARLGIEEPVPEIDENALIIGFARRFATYKRATLILSDLERLRRIMNNPEMPVYLIFAGKAHPRDEAGKEFLKKVYEVSQMPEFKGKILIIENYDMGSARLMVAGVDVWLNNPRRPLEASGTSGMKAGLNGVLNLSIYDGWWVEGYNGRNGWVIGEETTEPETEEDDIRDAQSLYDILENEVIPLYYENKEAWISMMKESIKSIAPRFSTHRMVKEYMTKFYTKAMEHGIWLVRDNFRWAREIAAWKKKVLENWGNVSIEKIITEDAKAMEVVINLGNLSPEDVKVELYYGVKVRDYIIEKPHIVELKRPESLGNGKYRYRYEGNALRNIINPCWHYAVRVYPYHSKLPYRFLMGGIIKWRGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI57</accession>
    <name>F0LI57_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_00234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466509.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00234"/>
    <dbReference type="EnsemblBacteria" id="ADT83211">
        <property type="protein sequence ID" value="ADT83211"/>
        <property type="gene ID" value="TERMP_00234"/>
    </dbReference>
    <dbReference type="GeneID" id="10040552"/>
    <dbReference type="KEGG" id="tba:TERMP_00234"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.234"/>
    <dbReference type="eggNOG" id="arCOG02985">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081250_1_0_2"/>
    <dbReference type="OMA" id="DEPYDGI"/>
    <dbReference type="OrthoDB" id="59863at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023596">
        <property type="entry name" value="Peptidase_PrsW_arch/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016933">
        <property type="entry name" value="PrsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="240" mass="26756" checksum="E52597FE2BCDBFE1" modified="2011-05-03" version="1">MDVLSTIIFFAYAPALALLWYFYHEDKFEPEPKRYVIGTFILGGTLSVIVAFIIESILTPGKVNFGYTIFPATAFYLALTAGIVEEPAKALAIRWPYKAGQMDGIMDGVVYGVAAGLGFAATENLLYGLGYGVGTTITRAFLTPIAHATWSAIVGVGYGLKAEGKIHSVTNYFALVILLHFIWDYYAFLAIAVPSYYILVIMLLFLNLALIRYFIMLGQKEDLEKQWWYWFVGGRRYGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI67</accession>
    <name>F0LI67_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L30e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl30e</name>
        <name evidence="7" type="ordered locus">TERMP_00244</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466519.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00244"/>
    <dbReference type="EnsemblBacteria" id="ADT83221">
        <property type="protein sequence ID" value="ADT83221"/>
        <property type="gene ID" value="TERMP_00244"/>
    </dbReference>
    <dbReference type="GeneID" id="26135582"/>
    <dbReference type="KEGG" id="tba:TERMP_00244"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.244"/>
    <dbReference type="eggNOG" id="arCOG01752">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130502_1_0_2"/>
    <dbReference type="OMA" id="RPHKIMA"/>
    <dbReference type="OrthoDB" id="117214at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_L30e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="L30/L30e/YlxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_L30e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_L30e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000948">
        <property type="entry name" value="Ribosomal_L7Ae_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="PTHR11449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449:SF1">
        <property type="entry name" value="PTHR11449:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00884">
        <property type="entry name" value="RIBOSOMALHS6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="6">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="101" mass="10696" checksum="85E438C81552190C" modified="2011-05-03" version="1">MDVAFELRKALETGKVVIGSNKTVKLAKIGGAKLIIVAKNAPKEVKDDIYYYAKLSNIPVYEYEGTSVDLGTVLGKPFVVASLAIVDPGESNILALAGGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI74</accession>
    <name>F0LI74_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Uridine phosphorylase</fullName>
            <ecNumber evidence="5 9">2.4.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_00251</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>phosphate + uridine = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.3" evidence="5 9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00251"/>
    <dbReference type="EnsemblBacteria" id="ADT83228">
        <property type="protein sequence ID" value="ADT83228"/>
        <property type="gene ID" value="TERMP_00251"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00251"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.251"/>
    <dbReference type="eggNOG" id="arCOG01324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_0_0_2"/>
    <dbReference type="OMA" id="MSDVFHL"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010058">
        <property type="entry name" value="Uridine_phosphorylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01718">
        <property type="entry name" value="Uridine-psphlse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="10">
        <location>
            <begin position="28"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="276" mass="30155" checksum="2762B223DC2F736B" modified="2011-05-03" version="1">MKFVSADRPQTEEGYQYHIACKPGDVARYVLLPGDPERVPKISALWDEAKEIAFHREYRTHTGKYKGIPISVTSTGIGGPSTAIAIEELAAIGADTFIRVGSTGAIQPGIEIGDLIIAKAAVRLEGTSKQYVRIEYPASADYEVTLALIEAAETLGVRYHVGITASTDSFYVGQARPGLNGYFPSFAKHLIDDLRQAKVTNFEMEAATLFTLANIYGLRAGCVCAVFANRVTNEFGKAGEKEAALVASEAVKILAEWDEEKEKKGKKYWFPSLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI79</accession>
    <name>F0LI79_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NiaP-like niacin transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466531.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00256"/>
    <dbReference type="EnsemblBacteria" id="ADT83233">
        <property type="protein sequence ID" value="ADT83233"/>
        <property type="gene ID" value="TERMP_00256"/>
    </dbReference>
    <dbReference type="GeneID" id="10040574"/>
    <dbReference type="KEGG" id="tba:TERMP_00256"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.256"/>
    <dbReference type="eggNOG" id="arCOG02682">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_6_2"/>
    <dbReference type="OMA" id="MSWWLVP"/>
    <dbReference type="OrthoDB" id="38526at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MFS" evidence="1">
        <location>
            <begin position="14"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="427" mass="46492" checksum="E13F2E454CE77CF2" modified="2011-05-03" version="1">MEVIENSRFGKFHYRLLAVLGTIWAFIAINTLSVAFIIPLLKKEPAFQGSLTKLGAMGSAALWGMLLGAWFFGILADYIGRKKSLSLAVATFGIASVVSSFVQSLDQLIVLRFIVGLGLGGSLPVASSYFAEFMPKKIRGAMISILESFWAIGTIIIGIVALIVKADWRGILLFGGAIILALPFLATLPESPRFLLLNGKIREAEEIIRRIFGVSVKLEMPKKEHRKITIAELWRKHAKTTFMLTVAWFSIAFAYYGFFIWLPKFLASTLNITVFKSFQYFIITALAQLPGYWSAAYFIEKVGRKKTLSGYLFVSGLAGLLFYKFASSGNAPMILLSAVLFSFFNLGAWGAIYAYTPELYPTSVRGTGTGWAGAMARIGGGLAPIVAGRVMEISTVGMAVLIIAIISIIGALDIAVLGKETKGKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI88</accession>
    <name>F0LI88_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467716.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01443"/>
    <dbReference type="EnsemblBacteria" id="ADT84418">
        <property type="protein sequence ID" value="ADT84418"/>
        <property type="gene ID" value="TERMP_01443"/>
    </dbReference>
    <dbReference type="GeneID" id="10041759"/>
    <dbReference type="KEGG" id="tba:TERMP_01443"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1443"/>
    <dbReference type="eggNOG" id="arCOG00519">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105338_0_0_2"/>
    <dbReference type="OMA" id="CRGWDTN"/>
    <dbReference type="OrthoDB" id="95849at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="151" mass="17611" checksum="E5D66C67B8E620C0" modified="2011-05-03" version="1">MRTLIIYVSIHHKNTEKIAKVIGDVLNARLVKPWAVKPEEILDYDLVGFGSGIYWWRHHWALLKLVDDLPKMEGKKAFIFSTAGMNIPWYNHRALRKKLKEKGFQIVGEFSCRGWDTNGWLAKIGGINRGHPNEKDLERARRFAEKLKENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIC9</accession>
    <name>F0LIC9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane bound hydrogenase MbhA-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01484</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467757.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01484"/>
    <dbReference type="EnsemblBacteria" id="ADT84459">
        <property type="protein sequence ID" value="ADT84459"/>
        <property type="gene ID" value="TERMP_01484"/>
    </dbReference>
    <dbReference type="GeneID" id="10041800"/>
    <dbReference type="KEGG" id="tba:TERMP_01484"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1484"/>
    <dbReference type="eggNOG" id="arCOG03099">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086615_2_2_2"/>
    <dbReference type="OMA" id="HWINVPP"/>
    <dbReference type="OrthoDB" id="78706at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34584">
        <property type="entry name" value="PTHR34584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019239">
        <property type="entry name" value="MrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="167" mass="18902" checksum="8EA2E7AF124E9E2C" modified="2011-05-03" version="1">MAFVTSFLWSLIVYLLLTAGSGNIIAWSREELIAGFIIAAVIGYLTRNIMDEKLEYFFNPRRWVLFIVYAIGPFFFAMAKANLDVAYRVITGKIRPGIVKISPGLTRDESRTLLANSITLTPGTFTLEIDEEGNLYVHWINVPPGKEKPTPEELCGYLPKWARRIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIG5</accession>
    <name>F0LIG5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenine phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466537.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00262"/>
    <dbReference type="EnsemblBacteria" id="ADT83239">
        <property type="protein sequence ID" value="ADT83239"/>
        <property type="gene ID" value="TERMP_00262"/>
    </dbReference>
    <dbReference type="GeneID" id="10040580"/>
    <dbReference type="KEGG" id="tba:TERMP_00262"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.262"/>
    <dbReference type="eggNOG" id="arCOG00031">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086256_1_0_2"/>
    <dbReference type="OMA" id="YEYTYLR"/>
    <dbReference type="OrthoDB" id="97021at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="237" mass="26830" checksum="123FD86CAF0CD964" modified="2011-05-03" version="1">MSQIKAVKEKLRVIRILKLLKKRYTYEELSKITGLPITVLNRYVRGKVLPSTDRAKELLEMLSPYINIEEEVKRRIQFDEHGLFDNMKILSDTNLMSLIAEEVASRYISKDISKVLTAATDGIPLAVHIANELNVDVVYAKKKKEVGVEKFYEVNYVPSASGSVMTLYLPQWALKRGEKVLIVDDVIRSGETQKALLEMCKQAGAVPVGMFFLISVGNVIDVLKNEYKIPVESLVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F0LII4</accession>
    <name>F0LII4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
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    <dbReference type="EnsemblBacteria" id="ADT83258">
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    <dbReference type="KEGG" id="tba:TERMP_00281"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="357" mass="40115" checksum="743B833C51E5BCD0" modified="2011-05-03" version="1">MARVLLKNVTKKFGNVVAVNNLNLEIRDGEFMVLLGPSGCGKSTTLRMIAGLETPTEGEIWIGDQLVNDIDPTKRNVAMVFQSYALYPHMTVFGNIEFPLRMAGVPKQERIKKVKEVAEFLGIADLLNRKPSELSGGQQQRVALARALVREPQVFLLDEPLSNLDAKIRTQMRFELKKLLSYELGITTVYVTHDQVEAMTMADRIAVMNKGILQQVGTPDEIFYKPKNTFVATFVGSPPMNLIEGSIVEKDGKILFETEHFSLQLPSDVPKAEEAILGFRPQHVEVSLAPKEGYVKGNLLGVEKLGVENYGHIGYGRLEIVVRLPEEIRVMRGEIYWKPQGNRIYIFDPKTRRAIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIK5</accession>
    <name>F0LIK5_THEBM</name>
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        <submittedName>
            <fullName evidence="2">Hypothetical damage-inducible dinF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466577.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00302"/>
    <dbReference type="EnsemblBacteria" id="ADT83279">
        <property type="protein sequence ID" value="ADT83279"/>
        <property type="gene ID" value="TERMP_00302"/>
    </dbReference>
    <dbReference type="GeneID" id="10040620"/>
    <dbReference type="KEGG" id="tba:TERMP_00302"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.302"/>
    <dbReference type="eggNOG" id="arCOG01731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_2"/>
    <dbReference type="OMA" id="MDGIWLA"/>
    <dbReference type="OrthoDB" id="52466at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="454" mass="50182" checksum="70B3CAB5C0B29388" modified="2011-05-03" version="1">MDGELRKRLWELAWPAILANISQTLVNLVDMIMVGQLGALAIASVGLGAQLSWFMMPIMFAISTGVLALVARFVGAKEYDMANLTLEQGIYLAFLVGIPVMAFGFLFGDDALRIMGASEDVIKLGYDYIRMYFLFYPINFMGFAAFSALRGAGDTKTPMKLSILMNVLNVVLNYLLIFGKFGFPRLEVKGAALASGLSIATAFVVGMFLFLSDRLVLKLKLSFRFDISLVKRILRIGIPATIERIIFSVYNFIYISIVTRFGTVALAAHQVGLRVESIAYMPAFGFNVATSALVGQSLGEGNPEKAEKVVYESLKMVTAFMSVMAVILIAFPKYLVMPFITKSDPNYWQVIHLAAIYLMIVGISEIPLGWLFVLSGALRGAGDTKSPMYITAVSKLLFRILPAYLLGFGFAIGSFRFEGLGVIAAWIAMSLETFATAGFFWWVFRRGKWKYIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIL3</accession>
    <name>F0LIL3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative antitoxin TERMP_00310</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Possibly the antitoxin component of a toxin-antitoxin (TA) module.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0330 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466585.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00310"/>
    <dbReference type="EnsemblBacteria" id="ADT83287">
        <property type="protein sequence ID" value="ADT83287"/>
        <property type="gene ID" value="TERMP_00310"/>
    </dbReference>
    <dbReference type="GeneID" id="26135651"/>
    <dbReference type="KEGG" id="tba:TERMP_00310"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.310"/>
    <dbReference type="eggNOG" id="arCOG02681">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170073_3_0_2"/>
    <dbReference type="OMA" id="IMIRDEV"/>
    <dbReference type="OrthoDB" id="124152at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00794">
        <property type="entry name" value="UPF0330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003847">
        <property type="entry name" value="Put_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02697">
        <property type="entry name" value="VAPB_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="73" mass="8496" checksum="5F326CBBD1F5FDC3" modified="2011-05-03" version="1">MGKTITISDDVYWELVRIKGKKSFSEVIRELIKKEGNLNILLIGFGTRSKEEAEKLEKELKEAQKWMQSLIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIP6</accession>
    <name>F0LIP6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467796.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01523"/>
    <dbReference type="EnsemblBacteria" id="ADT84498">
        <property type="protein sequence ID" value="ADT84498"/>
        <property type="gene ID" value="TERMP_01523"/>
    </dbReference>
    <dbReference type="GeneID" id="10041839"/>
    <dbReference type="KEGG" id="tba:TERMP_01523"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1523"/>
    <dbReference type="eggNOG" id="arCOG01292">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_3_2"/>
    <dbReference type="OMA" id="DCVGTAH"/>
    <dbReference type="OrthoDB" id="83293at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006004">
        <property type="entry name" value="Glut_synth_NADPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01316">
        <property type="entry name" value="gltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="2">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="158"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="480" mass="53002" checksum="7F5A75B920C54F15" modified="2011-05-03" version="1">MTKRKLIKNRVPTPERPAYERIKSFEEVNLGYNFDLALMEAERCLQCPENYAPCIKGCPVNINIPGFLAKLKEHRDNPYLAVKEALRVIWACNSLPAITGRVCPQEDQCEGVCVMGKVGDPINIGKLERFVADYARLHGIDDELLMEIIPKIEKKEQKVAVVGAGPAGLTCAAELAKMGYKVTIFEALHYPGGVLIYGIPEFRLPKQIVKKELKKLELLGVEIKTDHIVGRTVTIPELIEEYDAVFISTGAGTPKLPEVPGINLNGIYSANEFLTRVNLMKAYKFPKYDTPIKVGKKTIVIGAGNTAMDAARTALRLGSDVTIAYRRGREDMTARIEEIHHAEEEGVKFMFFVSPLEFIGDEHGNVKAVKFMKMKVLDEKESNGKRKIIPTGETITVEADTVIIAIGQVPNKIIWKTTPGLEITEKGTIVVDENLMTSIPGVFAGGDAIRGEATVILAMGDGRKAAKAIHEYLQRKSENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIR3</accession>
    <name>F0LIR3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467813.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84515">
        <property type="protein sequence ID" value="ADT84515"/>
        <property type="gene ID" value="TERMP_01540"/>
    </dbReference>
    <dbReference type="GeneID" id="26137052"/>
    <dbReference type="KEGG" id="tba:TERMP_01540"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1540"/>
    <dbReference type="eggNOG" id="arCOG03806">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158400_0_0_2"/>
    <dbReference type="OMA" id="MLKMKVY"/>
    <dbReference type="OrthoDB" id="123221at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014418">
        <property type="entry name" value="UCP004604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036216">
        <property type="entry name" value="UCP004604_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08967">
        <property type="entry name" value="DUF1884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004604">
        <property type="entry name" value="UCP004604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111057">
        <property type="entry name" value="SSF111057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="93" mass="10777" checksum="E922B8412D9CC462" modified="2011-05-03" version="1">MKEEIYELVKTTINELREEGLNPDIMLAGPEFLKHASEVLKECHLAVYEIKELNSDAVIADSQYLGQLKRASRRISIGLLFKEKDMWEEIQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIR8</accession>
    <name>F0LIR8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01545"/>
    <dbReference type="EnsemblBacteria" id="ADT84520">
        <property type="protein sequence ID" value="ADT84520"/>
        <property type="gene ID" value="TERMP_01545"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01545"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1545"/>
    <dbReference type="eggNOG" id="arCOG00014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_10_1_2"/>
    <dbReference type="OMA" id="TFCGYFA"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="39"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="329" mass="36072" checksum="57093544BDD50DF4" modified="2011-05-03" version="1">MHPVERLNCSLILTENGENLKAFQCATYEIKPTGGMAMFDVVAIGNLNYDIIMLVDRFPEFHEKIPAKNAHFGLGGAAGNTATWLANMGLRVGFIGAVGKDEIGEAHINFFKKIGIDTKGIKIVDVPSGVAVAIIKGEDKRIVKYLGANKYRELDYEYLSKTKHIHLSSNPEKLIIDTVNFAYEHGITVSLDIGEAKIPEEIEEKITYLLMNEDEFKRKFGNLDKISEVKAKNVIVTLNGGGALVRDEKGNIFEVKGLSAEVVDSTGAGDSFDAGLIYGVLKGWSLRDAAKLGMLLAYLTVQKVGARSAVIPLEEIKKRAEELNLNLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIZ4</accession>
    <name>F0LIZ4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466638.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="SMR" id="F0LIZ4"/>
    <dbReference type="STRING" id="391623.TERMP_00363"/>
    <dbReference type="EnsemblBacteria" id="ADT83340">
        <property type="protein sequence ID" value="ADT83340"/>
        <property type="gene ID" value="TERMP_00363"/>
    </dbReference>
    <dbReference type="GeneID" id="10040681"/>
    <dbReference type="KEGG" id="tba:TERMP_00363"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.363"/>
    <dbReference type="eggNOG" id="arCOG00826">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1514688_0_0_2"/>
    <dbReference type="OMA" id="VMDYKEF"/>
    <dbReference type="OrthoDB" id="78707at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="176" mass="20794" checksum="DCD46966292208BE" modified="2011-05-03" version="1">MEIVKVQNPVELKDKLLEFVFRVYRGTNGAYPALEWVEKKPSQDDFKGFKKVYEPFLEFRLEKEFDELYILKEGEKIVGTVALVYNLKGKDVWWVPEDIKSEETGLIEFFMVDPEYRGKGYGSKLLEFAVERLKELGKDVYIITFPHLEAYSYYLRKGFVKVMDYKEFVVLKLPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIZ6</accession>
    <name>F0LIZ6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA topoisomerase VI, subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466640.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00365"/>
    <dbReference type="EnsemblBacteria" id="ADT83342">
        <property type="protein sequence ID" value="ADT83342"/>
        <property type="gene ID" value="TERMP_00365"/>
    </dbReference>
    <dbReference type="GeneID" id="10040683"/>
    <dbReference type="KEGG" id="tba:TERMP_00365"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.365"/>
    <dbReference type="eggNOG" id="arCOG02452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118411_0_0_2"/>
    <dbReference type="OMA" id="TIAMFEN"/>
    <dbReference type="OrthoDB" id="94915at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="200" mass="22791" checksum="694CA5ED5BAF81BC" modified="2011-05-03" version="1">MKFGIPKLDELLGEIPEGSVVLIETLGNLGEEIVVEALKENSDKSIAFVTKRLKEEFEKIPELKNMKYIVFGEDFAPQELFKITYKLRQILSGYLVGLFFLQPLLVFHPQETVYKFFSEVSSITHDNKLVLIAILDKRLVDERTLAMFENVSTHVIEIAEELEKFRVIRGIRVKKSPKGSSGFYELIIKDGKITIGEPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ41</accession>
    <name>F0LJ41_THEBM</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466685.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00410"/>
    <dbReference type="EnsemblBacteria" id="ADT83387">
        <property type="protein sequence ID" value="ADT83387"/>
        <property type="gene ID" value="TERMP_00410"/>
    </dbReference>
    <dbReference type="GeneID" id="26135750"/>
    <dbReference type="KEGG" id="tba:TERMP_00410"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.410"/>
    <dbReference type="eggNOG" id="arCOG00874">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011771_2_1_2"/>
    <dbReference type="OMA" id="ECHRTSA"/>
    <dbReference type="OrthoDB" id="14047at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="103"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="303"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="454" mass="52182" checksum="BB2BF002A85D4E33" modified="2011-05-03" version="1">MVTLRIPDKSAKVIIEKAEPKVYFMIYEALSYKRDFGKWEKPESLYDPYEKSFPVGLIPRVKRLLNSKGYRVRIIDERKVEGINLNSEWNEKYKLRRYQQKAVRKAIKAKMGVLALPVGSGKTVVGLRIVHELDLSALIVVHTKELLYQWKEKVEEVLGVEAGIVGDNKWNEKPVTVAMIQTLLSRGADKLELPYAIVIFDECHRTSAAEKFYQLGMSLPQVYRFGLSATPWRRIRGEEIKIEGAIGPIIYEVKADELIREGFLAKPKFEIIQYKSKMPALAERYKELYEEMIMENEERNKAIVEKAIELAKEGHRVLIDVRRIDHGEILVKMLKERGVNAEFLSSQSPNRWEIFEKFKKGEIQVLVSTLLKEGVDIPEISAIILAGGGKSDIMTIQTIGRALRPKDGREAVIVDVQDDDPLLFTHFIEREKALKHYYGKFYDNGISTKVKQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ57</accession>
    <name>F0LJ57_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467877.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01604"/>
    <dbReference type="EnsemblBacteria" id="ADT84579">
        <property type="protein sequence ID" value="ADT84579"/>
        <property type="gene ID" value="TERMP_01604"/>
    </dbReference>
    <dbReference type="GeneID" id="10041920"/>
    <dbReference type="KEGG" id="tba:TERMP_01604"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1604"/>
    <dbReference type="eggNOG" id="arCOG04469">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028170_0_0_2"/>
    <dbReference type="OMA" id="HIALRKM"/>
    <dbReference type="OrthoDB" id="17086at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002823">
        <property type="entry name" value="DUF112_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01970">
        <property type="entry name" value="TctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="451" mass="48054" checksum="8AC368704A0C49E8" modified="2011-05-03" version="1">MDVGVLLVQATFLTILSVLMYIIIGMIPGTDETATIAPITLALLAAGFDPLLVLAWFMGTIVAFKAADAVPTALAAIPGGVMAVPQVPDALVARKYGYSEIILRKGITASVIGTVVAIVIALPLSFYLTPLGDLLKTQMGPLNWPGWVYIIVAGIIVLAVMSKAKILALLAIFPFAMLVQGIRAVYGKPVFISIFLAITIGPILYELLTLISPNNHHLKRDSYARIKLVKTGKITLNPLHHLDRLEVTLSSIFAGISSILSAFMSPVGLTILFGDLIKEAEKDELKGSLRAYAVRDAIKNATYIGGTLIPLIAIGVPTGPMSAGPAAPFFAKLDAFNGLSPRDILLQRYSTPTIMLVIAYVTLLAALLTYVILIKYSKPLTRFVFKKIPAEALYSTFLAIVLVLSYMEAGIAGIFGSILVGLISATFARNGVSIGVLFMVLVAAPYLVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ88</accession>
    <name>F0LJ88_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467908.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01635"/>
    <dbReference type="EnsemblBacteria" id="ADT84610">
        <property type="protein sequence ID" value="ADT84610"/>
        <property type="gene ID" value="TERMP_01635"/>
    </dbReference>
    <dbReference type="GeneID" id="26137167"/>
    <dbReference type="KEGG" id="tba:TERMP_01635"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1635"/>
    <dbReference type="eggNOG" id="arCOG00001">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_2_2"/>
    <dbReference type="OMA" id="IQIHILH"/>
    <dbReference type="OrthoDB" id="118418at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="102" mass="11724" checksum="C2C36DE1F1E22FA3" modified="2011-05-03" version="1">MIRRILLGFMGLHILHHASKEPITGVFMIEELKKHGYEVSPGTIYPLLHKMEVSGLLKSRWEVRDGRRIRLYEITPKGLEVLEEGKKKVKELCNEILGDCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJB1</accession>
    <name>F0LJB1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Maltose/maltodextrin transport ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467931.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01658"/>
    <dbReference type="EnsemblBacteria" id="ADT84633">
        <property type="protein sequence ID" value="ADT84633"/>
        <property type="gene ID" value="TERMP_01658"/>
    </dbReference>
    <dbReference type="GeneID" id="10041974"/>
    <dbReference type="KEGG" id="tba:TERMP_01658"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1657"/>
    <dbReference type="eggNOG" id="arCOG00177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OMA" id="PRNMYDK"/>
    <dbReference type="OrthoDB" id="88924at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="375" mass="42221" checksum="9134C73736EB8657" modified="2011-05-03" version="1">MAEVKLINVWKKFGEVTAVQDMSLHVKDGEFMILLGPSGCGKTTTLRMIAGLEEPTKGQIYVGDKLVADPEKGVFVPPKDRDIAMVFQSYALYPHMTVYDNIAFPLKLRKVPKQEIDRRVREVAEMLGLTELLKRKPRELSGGQRQRVALGRAIVRQPQVFLMDEPLSNLDAKLRVRMRAELKKLQKQLGVTTIYVTHDQVEAMTMGDRIAVINAGILQQVGTPDEVYNKPANVFVGGFIGSPAMNFLDASVVEDERGVWVDFGEFKLKLLEDQAEVLRELGYIGKEVIFGIRPEDLYDAMFAQVKIPGENMIRAMVDIVENLGSERIVHLRVGNLTFVGAFHAESMVKEGQEIDVVFDMKKVHIFDKKTEKAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJF7</accession>
    <name>F0LJF7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466721.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00446"/>
    <dbReference type="EnsemblBacteria" id="ADT83423">
        <property type="protein sequence ID" value="ADT83423"/>
        <property type="gene ID" value="TERMP_00446"/>
    </dbReference>
    <dbReference type="GeneID" id="10040764"/>
    <dbReference type="KEGG" id="tba:TERMP_00446"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.446"/>
    <dbReference type="eggNOG" id="arCOG03639">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086262_0_0_2"/>
    <dbReference type="OMA" id="FMHNGDL"/>
    <dbReference type="OrthoDB" id="97733at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="265" mass="30870" checksum="550581E645262BE7" modified="2011-05-03" version="1">MCRILFAVGDGKRVRPLLEALLKSSEHDPYKLARKKGSQHRDGWGYLLLKDGYIEHYRSESAIFEDRKKVKEAMEKLDGFVIFMAHTRAASQGEKNLFNVQPFGFSTRRGFIFWTLHNGDLNKKQLIEMGELNPEELKGASDSYVMGAYLCRFLEGIEKEHLLRRFIEIKTATRSLMNTATLLMNNKKEIRAFITAYMTDVYASDTLNYYYGRLLYFEGADVFATVSSTFEHYSYIPFEEVENGTAFYVKIYPKTERFEIEEVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJH6</accession>
    <name>F0LJH6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466740.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00465"/>
    <dbReference type="EnsemblBacteria" id="ADT83442">
        <property type="protein sequence ID" value="ADT83442"/>
        <property type="gene ID" value="TERMP_00465"/>
    </dbReference>
    <dbReference type="GeneID" id="26136020"/>
    <dbReference type="KEGG" id="tba:TERMP_00465"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.465"/>
    <dbReference type="eggNOG" id="arCOG03817">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155678_0_0_2"/>
    <dbReference type="OMA" id="FHIEDEM"/>
    <dbReference type="OrthoDB" id="98464at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="137" mass="16201" checksum="9866889F56BEDF1F" modified="2011-05-03" version="1">MKIVVKPEVGWRKVTFHIEDEMFNQIKEICMRHGFRVEEGIKIILLGEFLDYDPGEDVEALRKEVKELEERLYELEGKWSPLKFSSYGIALDNRNLAIQLSGMIAENKRLREMLGKEEKEYGDIEKLIHYYLSFEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJN7</accession>
    <name>F0LJN7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="10" type="ordered locus">TERMP_01704</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the protein translocation apparatus. Forms a complex with SecF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467977.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01704"/>
    <dbReference type="EnsemblBacteria" id="ADT84679">
        <property type="protein sequence ID" value="ADT84679"/>
        <property type="gene ID" value="TERMP_01704"/>
    </dbReference>
    <dbReference type="GeneID" id="10042020"/>
    <dbReference type="KEGG" id="tba:TERMP_01704"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1703"/>
    <dbReference type="eggNOG" id="arCOG03055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007894_5_1_2"/>
    <dbReference type="OMA" id="SAHLQMM"/>
    <dbReference type="OrthoDB" id="14000at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_A">
        <property type="entry name" value="SecD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024912">
        <property type="entry name" value="SecD_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT84679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="507" mass="55922" checksum="16642DC1042C5F3E" modified="2011-05-03" version="1">MNWKKLFLNWRILLLTIFILGSIASLLTYGLTFGLDISGGTAITVKLEKPVDQSTMEQVKISLEKRLNQLGVKDIKVEPWGNQYLIVKVAGVTEEEARSVKETIERQGVFYAEFEGVIFATGKDIVQVFSIQIEPKGTYYEWSVPFRISKQAAEKFAELAKDKAGYPVDMFLDPPVNSLFVVSQDGYNLMTTDFKAEAPNAMPLTERIKKAFNIDTIAYTNQSAEEIAKLAKNKELVVLVGVDKNLKDQLEARGIKVRYFEPQQGESLKNVITRALGLYGPYSLGSGLAQGVPQTNVRITGTAPNQYLAQQEAQVIAVVLSSGSLPVKVYVEGSQYISPELGENFKRQVLIAGIAALIVVGLIIWLHYRKLKIAIPVTFTSLSEVIIILGIAALIKWNLDLPSIAGIIAAIGTGVDQQIVITDELLGRRGREKIVKRSSILKRMGRAFFVILASATTTVVAMSFLFKFFVGGLRGFAFTTILGVMIGILITRPAYAEIAKFLIGEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJQ0</accession>
    <name>F0LJQ0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-alanine glycine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467990.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01717"/>
    <dbReference type="EnsemblBacteria" id="ADT84692">
        <property type="protein sequence ID" value="ADT84692"/>
        <property type="gene ID" value="TERMP_01717"/>
    </dbReference>
    <dbReference type="GeneID" id="26137081"/>
    <dbReference type="KEGG" id="tba:TERMP_01717"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1716"/>
    <dbReference type="eggNOG" id="arCOG05006">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024867_1_2_2"/>
    <dbReference type="OMA" id="PMMALFY"/>
    <dbReference type="OrthoDB" id="29565at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00873">
        <property type="entry name" value="NA_ALANINE_SYMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="515" mass="55574" checksum="192E5271351BF0DB" modified="2011-05-03" version="1">MGAIMEFINWLDGMVWGPPIMILLLGTGLFLTIVLRGIQFRRLGWSIRYTLFEGRKKQGEGDITPFQALMATIAGTVGIGNIAGVATAIHLGGPGALFWMWMTALVGMATRYSEGLLGVAFRSKLPDGTMIGGSFNALERGFAEVKVSKTGRTIATIFMLIFAAFIGYEATKLSGGLMILAVIIAILFAILALYLQKESSLPTLGKVLAILFALFAAISAFGIGNMTQSNSLALGMEVAFNVPHWVTGIIFAILTFIVTIGGIKRIGEFTEALVPFMAIVYFIFAIGVWIKFAGQLPSAISLILKDAFTGSAVAGGAVGTTIRWGVARGLFSNEAGLGTASMAHAAARTDNPSRQAHVAMLGPFIDTIIICSLTGISIVATGAWQTGKTSTALTQEAFARAFGHIGEIMVVIGVILFAYSTVLAWNFYGRQNIMYLAKWIEGDPEKFARLYPRLHLIYNILFVIFIYIGATTVLESVWTFSDMMNGLMAIPNLVGLLVLYSVIKKYTDEFIKENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJV6</accession>
    <name>F0LJV6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466791.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00516"/>
    <dbReference type="EnsemblBacteria" id="ADT83493">
        <property type="protein sequence ID" value="ADT83493"/>
        <property type="gene ID" value="TERMP_00516"/>
    </dbReference>
    <dbReference type="GeneID" id="10040834"/>
    <dbReference type="KEGG" id="tba:TERMP_00516"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.516"/>
    <dbReference type="eggNOG" id="arCOG05736">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180516_0_0_2"/>
    <dbReference type="OMA" id="GKPHIKS"/>
    <dbReference type="OrthoDB" id="109822at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="108" mass="12496" checksum="C4162EFE8362CAE5" modified="2011-05-03" version="1">MDKKKTIEAIKNHSNYSREIYEMHEESINNAIDNYEQLKEDYLNDHSRARIVRIVINDDNDLPLAIEFHKKDDSFKGFSIAIGKPYIKSDNNGENRRGDGESYDEGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJY1</accession>
    <name>F0LJY1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate synthase (NADPH), small chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466816.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00541"/>
    <dbReference type="EnsemblBacteria" id="ADT83518">
        <property type="protein sequence ID" value="ADT83518"/>
        <property type="gene ID" value="TERMP_00541"/>
    </dbReference>
    <dbReference type="GeneID" id="10040859"/>
    <dbReference type="KEGG" id="tba:TERMP_00541"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.542"/>
    <dbReference type="eggNOG" id="arCOG01292">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_3_2"/>
    <dbReference type="OMA" id="DRANMPG"/>
    <dbReference type="OrthoDB" id="83293at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="351" mass="38733" checksum="E66E85B8B8DEC74E" modified="2011-05-03" version="1">MKGMRFAFLCREKPEPTGKKVAIIGAGPAGLSAAGYLVCHGHEVHIYDKLPEPGGLMLFGIPEFRIPIYRVRKGYEELENVFEVKFFPKTKVAFGNGEEEGDKFVENVINFNELVEKYDAVLIATGTWESWMPNIEGVELEGVYPALDYLFKIKSAKLGHMSWDEVPPIEGKRVMVVGAGHTAVDAAMESLLLGAEKVYMSYRRTIREAPAGAYEINLLKQRGVKWLELTVPVRIVGEYGKVIAVELQKCKLGEPDESGRRRPIPIEGSNFQIDVDYVVFAVGQRPTPPFAGDVGIAVDKKGRIVVDSRHMTSREGVFAAGDVVIGPSKVGRAVLDGLLAAESMHMWLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJZ3</accession>
    <name>F0LJZ3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ordered locus">TERMP_00553</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466828.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00553"/>
    <dbReference type="EnsemblBacteria" id="ADT83530">
        <property type="protein sequence ID" value="ADT83530"/>
        <property type="gene ID" value="TERMP_00553"/>
    </dbReference>
    <dbReference type="GeneID" id="10040871"/>
    <dbReference type="KEGG" id="tba:TERMP_00553"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.554"/>
    <dbReference type="eggNOG" id="arCOG04338">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057426_2_0_2"/>
    <dbReference type="OMA" id="CACCGIP"/>
    <dbReference type="OrthoDB" id="108934at2157"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00317">
        <property type="entry name" value="cobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ADT83530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="231" mass="25688" checksum="2D615BC50273F935" modified="2011-05-03" version="1">MKNLISFMTRIPLKGDFEKARQGIWAFPLLAVITSALSTIILYFNVPLKNILAVLLLYFTVGLLHLDGLADFADGIMAKGDRERKIKAMKDLNTGIAGIFAVVMILFVQVYSLSYTPFYALFLAELNSKYAMVLALSTKKPLGEGLGAYFMEAVSRKQLLLATMIYTLLLVPFFLYEWRTVISVLGFLIGAYIIKLSLDNFGGLNGDCIGAVAEITRGGTLLILAFIWWYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK15</accession>
    <name>F0LK15_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS</fullName>
            <shortName evidence="1">tRNA(Ile2)-agm2C synthetase</shortName>
            <ecNumber evidence="1">6.3.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile2) agmatidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tiaS</name>
        <name evidence="4" type="ordered locus">TERMP_00575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:43608"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10626"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83545"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TiaS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.22" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466850.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00575"/>
    <dbReference type="EnsemblBacteria" id="ADT83552">
        <property type="protein sequence ID" value="ADT83552"/>
        <property type="gene ID" value="TERMP_00575"/>
    </dbReference>
    <dbReference type="GeneID" id="10040893"/>
    <dbReference type="KEGG" id="tba:TERMP_00575"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.576"/>
    <dbReference type="eggNOG" id="arCOG01115">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_675459_0_0_2"/>
    <dbReference type="OMA" id="GMCTTYL"/>
    <dbReference type="OrthoDB" id="58019at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01892">
        <property type="entry name" value="tRNA_Ile2_agm2C_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013696">
        <property type="entry name" value="DUF1743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024913">
        <property type="entry name" value="tRNA_Ile2__agm2C_synt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08489">
        <property type="entry name" value="DUF1743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUF1743" evidence="3">
        <location>
            <begin position="140"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="2">
        <location>
            <begin position="272"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="422" mass="48359" checksum="5F2A7ED7E9F81A7E" modified="2011-05-03" version="1">MMLHIGLDDTDSPNGMCTTYLGALLYREISRLAEPLDLPKLIRLNPNVPYKTRGNGAVAMSFEADEEDVPKIKNLVLEFVEELADLTHENTNPGVVFLEGEIPEELTEFTYRAIWEHISIEEAEKVAKDVDAEIYKFKLGRGIVGALAAIGHPLKEFTYELLAYRKRRLWGTPRKVNRESVFEMDRQFYPFTYDNVDPYKGSVLITPHGKDPVLVGIRGIDKNKVLLAFESITIEEPLEFYQIFKTNQSTDEHLRFKKIADLKQFDNAVIKAKVVKSYWEKGRHVFFEVDDGTGRLRVAAFEPTKGFRRYVRMLIEGDEIIAAGGVKEFEGVLTLNLEKFYPVKLAKKIEYRKPKCPKCGGTMKSKGDYLKCKKCGYKMPKVLIPVEVPRKLQKKIYEVPPDARRHLSRPLVLPLGEEKILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK16</accession>
    <name>F0LK16_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoenolpyruvate carboxylase</fullName>
            <shortName evidence="1">PEPC</shortName>
            <shortName evidence="1">PEPCase</shortName>
            <ecNumber evidence="1">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ppcA</name>
        <name evidence="2" type="ordered locus">TERMP_01753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PEPCase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468025.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01753"/>
    <dbReference type="EnsemblBacteria" id="ADT84728">
        <property type="protein sequence ID" value="ADT84728"/>
        <property type="gene ID" value="TERMP_01753"/>
    </dbReference>
    <dbReference type="GeneID" id="10042069"/>
    <dbReference type="KEGG" id="tba:TERMP_01753"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1752"/>
    <dbReference type="eggNOG" id="arCOG04435">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517433_0_0_2"/>
    <dbReference type="OMA" id="QSAFRYD"/>
    <dbReference type="OrthoDB" id="23334at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01904">
        <property type="entry name" value="PEPcase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007566">
        <property type="entry name" value="PEP_COase_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14010">
        <property type="entry name" value="PEPcase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006677">
        <property type="entry name" value="UCP006677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02751">
        <property type="entry name" value="PEPCase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="476" mass="55184" checksum="6F1B7A38A3A4F235" modified="2011-05-03" version="1">MIPKTMSTQHPDNVYIPFFAREPQLGGEDEIIEAFYAFSVLGIEEQMWDFEGKEVDEFVVKKLLERYPHFFRKHKLGEDFRLTPRVPNPSVEKAEAKLLLETLESISRSADYSKIFYGKEIAPIFEVILPMTTSANEINRVYDLYKRYIVGKQYKRVYDVKLYEWIGKFFPEEINVIPLFETKDAILNSAEILREYLHGKDFEYQRVFLARSDPAMNYGLISAVVYDKYALFKLQELEEEESVSIYPIIGVGSAPFRGHLVPENVENVLEEYRGAQTFTIQSSFKYDNPPREVIKAVEKIKSSKRKEAEPINGQILLILRKYEIEYSKQIKALAKLVREVAKFVPSRRKRKLHIGLFGYARDVNGFALPRAIKFTASLYSLGVPPEVLGLNALSEKDVEVISNVYNGIYKDLSLAFRYFNPKSAEKFKFLRDILKMSQLFEFERNEEHCEITNKILDGEINEELIIKAASIRGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK20</accession>
    <name>F0LK20_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ECF transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468029.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01757"/>
    <dbReference type="EnsemblBacteria" id="ADT84732">
        <property type="protein sequence ID" value="ADT84732"/>
        <property type="gene ID" value="TERMP_01757"/>
    </dbReference>
    <dbReference type="GeneID" id="10042073"/>
    <dbReference type="KEGG" id="tba:TERMP_01757"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1756"/>
    <dbReference type="eggNOG" id="arCOG00202">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="HEFTWDF"/>
    <dbReference type="OrthoDB" id="92866at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="264" mass="29670" checksum="E671D5FF5FEAF4A9" modified="2011-05-03" version="1">MIEVKNLWHIYEGKRIALKNVSLSFGNEIVALVGPNGSGKTTLAKHFNGLLKPTKGEVFIDGINTKNASVAELSRIVGYVFQNPENMFFEENVFKEVAFGPKNLGLSGEALEERVKWALRIVNLSGYEDRSPYSLSGGEKQRLAIACILAMKPKYVILDEPTTGLDEKSSKSVKEVIKKLRKEGHGIMLITHDMELVLELAERVVLLYDGIKVFDGSVDEFFQLDLRNYEMEIPELLRISKSLGISFVRNVDEFVNFLLERVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK57</accession>
    <name>F0LK57_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the carbamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468065.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01794"/>
    <dbReference type="EnsemblBacteria" id="ADT84769">
        <property type="protein sequence ID" value="ADT84769"/>
        <property type="gene ID" value="TERMP_01794"/>
    </dbReference>
    <dbReference type="GeneID" id="10042110"/>
    <dbReference type="KEGG" id="tba:TERMP_01794"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1793"/>
    <dbReference type="eggNOG" id="arCOG00863">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076278_0_0_2"/>
    <dbReference type="OMA" id="QPMDVAG"/>
    <dbReference type="OrthoDB" id="77437at2157"/>
    <dbReference type="BRENDA" id="2.7.2.2">
        <property type="organism ID" value="12861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00746">
        <property type="entry name" value="arcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="316" mass="34678" checksum="957ACC0F31F401D6" modified="2011-05-03" version="1">MRKRVVIALGGNAILQRGQKGTYDEQMENVKKTAKQIVDIILNNDYEVVITHGNGPQVGALLLHMDAGQQLYGIPAQPMDVAGAMTQGQIGYMIQQAITNELKRRGIYKPVATIVTQVLVDKNDPAFQNPSKPVGPFYDEETAKRLAKEKEWVVVEDAGRGWRRVVPSPDPKDIIEKDIIRDLVEKGFIVIASGGGGIPVIEENGQLKGVEAVIDKDLAGEKLAEVVNADIFMILTDVNGAAINYGKPNERWLHKVAVDELRKYYEEGHFKKGSMGPKVLAAIRFVEWGGERAVIAALDKAVDALEGRTGTQVIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK75</accession>
    <name>F0LK75_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MoaD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468083.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01812"/>
    <dbReference type="EnsemblBacteria" id="ADT84787">
        <property type="protein sequence ID" value="ADT84787"/>
        <property type="gene ID" value="TERMP_01812"/>
    </dbReference>
    <dbReference type="GeneID" id="26137328"/>
    <dbReference type="KEGG" id="tba:TERMP_01812"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1811"/>
    <dbReference type="eggNOG" id="arCOG00536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_1_2_2"/>
    <dbReference type="OMA" id="YFARYRS"/>
    <dbReference type="OrthoDB" id="119587at2157"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010038">
        <property type="entry name" value="MoaD_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="PTHR33359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01687">
        <property type="entry name" value="moaD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="87" mass="9786" checksum="FC4B91F772580BBD" modified="2011-05-03" version="1">MKVKVKYFARFRELAGVSEEIVELPDGAKVKDLIKIIKERHPKFKDEVFEQSEDADVNVSRNGSYVNFDEELKDGDVVALFPPASGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK86</accession>
    <name>F0LK86_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01823"/>
    <dbReference type="EnsemblBacteria" id="ADT84798">
        <property type="protein sequence ID" value="ADT84798"/>
        <property type="gene ID" value="TERMP_01823"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01823"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1822"/>
    <dbReference type="HOGENOM" id="CLU_3302929_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="39" mass="4882" checksum="EC955BB1B94C81E1" modified="2011-05-03" version="1">MDPEKFYEFLNWHMHSYDENTGRIFKKNHNLHINEFLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKB8</accession>
    <name>F0LKB8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="9">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rtcB</name>
        <name evidence="10" type="ordered locus">TERMP_00599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 9">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466874.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00599"/>
    <dbReference type="EnsemblBacteria" id="ADT83576">
        <property type="protein sequence ID" value="ADT83576"/>
        <property type="gene ID" value="TERMP_00599"/>
    </dbReference>
    <dbReference type="GeneID" id="10040917"/>
    <dbReference type="KEGG" id="tba:TERMP_00599"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.600"/>
    <dbReference type="eggNOG" id="arCOG04246">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022279_0_1_2"/>
    <dbReference type="OMA" id="QTRGVEC"/>
    <dbReference type="OrthoDB" id="22545at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="6">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="327"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="376"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="402"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="479" mass="53166" checksum="32D06C9B8A491168" modified="2011-05-03" version="1">MVPLKRIDQIRWEIPKFDKRMRVPGRVYADDVLIQKMRQDRTLEQAANVAMLPGIYKYSIVMPDGHQGYGFPIGGVAAFDAKEGVISPGGVGYDINCGVRLIRTNLTEKDVRPKIKQLIDTLFKNVPSGLGSKGRVRLQWTQLDDVLAEGAKWAVDNGYGWREDLERLEEGGGMEGANPSYVSDTAKRRGAPQLGSLGSGNHFLEVQVVDKVFDPEVAEVYGLFEGQVVVMVHTGSRGLGHQVASDYLRIMEKANRKYRIPWPDRELVSVPFQSEEGQRYFSAMKAAANFAWANRQMITHWVRESFEEVFRQKAEDLGMHIVYDVAHNIAKLEEHEVDGRKVKVVVHRKGATRAFPPGHEAVPRIYRDVGQPVLIPGSMGTASYVLAGTEGAMKEAFGSTCHGAGRVLSRKAATRQYRGDRLRNELMQRGIYIRAASLRVVAEEAPGAYKNVDNVVNVVAKAGIAKLVARMRPIGVAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKC5</accession>
    <name>F0LKC5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Elongation factor 2</fullName>
            <shortName evidence="7">EF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fusA</name>
        <name evidence="9" type="ordered locus">TERMP_00606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466881.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00606"/>
    <dbReference type="EnsemblBacteria" id="ADT83583">
        <property type="protein sequence ID" value="ADT83583"/>
        <property type="gene ID" value="TERMP_00606"/>
    </dbReference>
    <dbReference type="GeneID" id="10040924"/>
    <dbReference type="KEGG" id="tba:TERMP_00606"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.608"/>
    <dbReference type="eggNOG" id="arCOG01559">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_1_2"/>
    <dbReference type="OMA" id="GVMTQTE"/>
    <dbReference type="OrthoDB" id="1642at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_A">
        <property type="entry name" value="EF_G_EF_2_A"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004543">
        <property type="entry name" value="Transl_elong_EFG/EF2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00490">
        <property type="entry name" value="aEF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Diphthamide" evidence="7">
        <location>
            <position position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="732" mass="82124" checksum="09BCB5F884D31DF5" modified="2011-05-03" version="1">MGRREEMIAKIKELMTQPERIRNMGIAAHIDHGKTTLSDNLLAGAGMISEELAGKQLVLDFDEQEQARGITINAANVSMVHEYEGKEYLINLIDTPGHVDFGGDVTRAMRAIDGAIIVVDAVEGVMPQTETVLRQALREYVKPVLFINKVDRLIRELKLTPQQMQERFVKIITDVNRLIKRYAPEEFKKQWLVNVNDGSVAFGSAYYNWALSVPFMKKTGVSFKEIIDLTNAGDLKTLRKKAPLHVVVLDMVVRHLPNPLEAQKYRIPHLWRGDINSDVGQAMLKCDPKGKMVMVVTKIIIDKHAGEVSTGRVWSGTVKTGQEVYLISAKRKARIQQVGIYMGPERVNMEAVPAGNIVAVTGLRDAMAGETVAQEPIEPFEALHYTSEPVVTVAIEAKNIKDLPRLIEALRQLAKEDPTLQVKIDQETGQHLLSGMGELHLEVKLYKLKEDWGIDVDVSEPIVVYRESITKVSPIVEGKSPNKHNRFYVVVEPMPDNIYQAIRDGEIPEGRPKDRKAVAKKLAELGMDYDIARGIVDVYRGNIFLDNTKGIQYLNEVMDLLIDGFHQAMDEGPLAKEPVMKVIVRLVDAQIHEDNVHRGPAQIYPAIRTAIHCAMMKAGPVLYEPYQKVIINVPYEYMGPVSREISQRRGQLLDMRQEGEVMTIIAKAPVAEMFGFAGAIRSATSGRALWSTEHAGFERVPQELAIQIIRQIRQRKGLDPNPPTEKDICPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKE0</accession>
    <name>F0LKE0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vitamin B12 ABC transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_00621</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466896.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00621"/>
    <dbReference type="EnsemblBacteria" id="ADT83598">
        <property type="protein sequence ID" value="ADT83598"/>
        <property type="gene ID" value="TERMP_00621"/>
    </dbReference>
    <dbReference type="GeneID" id="10040939"/>
    <dbReference type="KEGG" id="tba:TERMP_00621"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.623"/>
    <dbReference type="eggNOG" id="arCOG01007">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_1_2"/>
    <dbReference type="OMA" id="MQGVFGN"/>
    <dbReference type="OrthoDB" id="36067at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="332" mass="36050" checksum="BF990436EF55AB48" modified="2011-05-03" version="1">MKKFMTLVLSSVILIFTGIAFGSVNLPFSKILSTFTLENLKLAVYDPKKLGTTETIILQIRMPRVLLAYLVGLSLASAGTASQALFKNPLADPYILGISGGAAVGAALAALYFPTHMGIFALVGALISVGIVYNISKIDDHIPVDTLLLAGIAFGFFAHAVTSYLLYVGRERIHMAIFWLMGTFNGATWDDVKLVLFSSIVGFSFLMLRWKELNLLLFGEESIALGLDLNFYRKIIIFVISMLTAFAVATSGIIGFVGLISPHAMRLMFGPNHKNLLPAAALFGGSLMVFADLLARIVLKPAEIPVGIITALFGAPFFIYLLMKRKRGELYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKF4</accession>
    <name>F0LKF4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylornithine deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466910.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00635"/>
    <dbReference type="MEROPS" id="M20.A24"/>
    <dbReference type="EnsemblBacteria" id="ADT83612">
        <property type="protein sequence ID" value="ADT83612"/>
        <property type="gene ID" value="TERMP_00635"/>
    </dbReference>
    <dbReference type="GeneID" id="26136035"/>
    <dbReference type="KEGG" id="tba:TERMP_00635"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.637"/>
    <dbReference type="eggNOG" id="arCOG01107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_4_2"/>
    <dbReference type="OMA" id="SWTDAIN"/>
    <dbReference type="OrthoDB" id="14646at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="152"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="350" mass="39589" checksum="0A3287EBFE0975DF" modified="2011-05-03" version="1">MKAERAKEILINLLRIPSPSGKEDRLALHIMEFLHKLGYDVHIESDGEIINLIVNPDAELFYEVHMDTIDIRVQPFIRGNIVYGTGASDVKGGLASILLMLESLKKEDKDLNVGIVFVSDEEKGGRGSALFMERYRPKMAIVLEPTDLEVHIAHAGNIEAYFEVDGKEAHGACPESGENAIELTYKMLEELKALEPFKQKGKYFDPHVGLQELVCENPYYLIPALCKGRLEARLLPEQEVEDILDLFDPILEEYTLRYEYTEIWDGYELDESEEIVQIAKRAMDLTGLDEFGGMRSWTDAINFMYNGTKTIVFGPGNLDISHTKNEHIDVRDVVKASEFLTAVNDIFGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKM0</accession>
    <name>F0LKM0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468150.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01879"/>
    <dbReference type="EnsemblBacteria" id="ADT84854">
        <property type="protein sequence ID" value="ADT84854"/>
        <property type="gene ID" value="TERMP_01879"/>
    </dbReference>
    <dbReference type="GeneID" id="10042195"/>
    <dbReference type="KEGG" id="tba:TERMP_01879"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1878"/>
    <dbReference type="eggNOG" id="arCOG00347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075000_1_0_2"/>
    <dbReference type="OMA" id="MPVRIYE"/>
    <dbReference type="OrthoDB" id="115684at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004425">
        <property type="entry name" value="CHP00061"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00161">
        <property type="entry name" value="TIGR00161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="240" mass="26892" checksum="438AC8FCEFCD98E1" modified="2011-05-03" version="1">MEKPVRLVLPKIENPIFIEGYPGIGLVGHIAANFLAKELNMEMIGYIESPFIPPMSLILEGKPNPPLRFYGKDNLIIAVADIYVPPTLVNEIAKEIISYLKETNAQKLISIGGMGIGFFKEQMEVWGVGANEDLNKELEGLGVKILQYGSIMGMSGKLLWEASKEKINGYVLLGETFGDRPDPRAAANVIEVIKKLTPIEISTEPLIKEAEMIEEQLRKMHEQMEMARKKAEKQYESIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKM9</accession>
    <name>F0LKM9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="7">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpS</name>
        <name evidence="10" type="ordered locus">TERMP_01888</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468159.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01888"/>
    <dbReference type="EnsemblBacteria" id="ADT84863">
        <property type="protein sequence ID" value="ADT84863"/>
        <property type="gene ID" value="TERMP_01888"/>
    </dbReference>
    <dbReference type="GeneID" id="10042204"/>
    <dbReference type="KEGG" id="tba:TERMP_01888"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1887"/>
    <dbReference type="eggNOG" id="arCOG01887">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032621_0_1_2"/>
    <dbReference type="OMA" id="SIYHRFM"/>
    <dbReference type="OrthoDB" id="33997at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_A">
        <property type="entry name" value="Trp_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020653">
        <property type="entry name" value="Tryptophan-tRNA-ligase_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="81"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT84863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="384" mass="44788" checksum="B97C6DBD19A827BD" modified="2011-05-03" version="1">MAEFKVTPWDVEGMVDYDKLIKEFGTQPLTDELLEKTAVLTKSELPLYFRRRFFFSHRDYDLVLKDYEEGRGFFLYTGRGPSGPMHIGHIIPFFATKWLQEKFGVNLYVQITDDEKFLFKPNLSFEDTKRWAYENILDIIAVGFDPDKTFIFQDSEFTKIYEMAIPIAKKVTYSMAKAVFGFTEQSKIGMIFYPAIQAAPTFFEKRRCLIPAAIDQDPYWRIQRDFAESLGYYKTAALHSKFVPPLTGLEGKMSASKPETAVYLTDDPEEAGKKIWKFALTGGQPTVKEQREKGGNPEKCVVFKWLEIFFEPDDKALLERYHACKSGALLCGECKRYLIKKVQEFLKEHQKRREKAKDEIEKFKYTGELAREQWDKAIPEPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKN4</accession>
    <name>F0LKN4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type tungstate transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468164.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01893"/>
    <dbReference type="EnsemblBacteria" id="ADT84868">
        <property type="protein sequence ID" value="ADT84868"/>
        <property type="gene ID" value="TERMP_01893"/>
    </dbReference>
    <dbReference type="GeneID" id="10042209"/>
    <dbReference type="KEGG" id="tba:TERMP_01893"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1892"/>
    <dbReference type="eggNOG" id="arCOG00166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_14_2_2"/>
    <dbReference type="OMA" id="EVGVAMM"/>
    <dbReference type="OrthoDB" id="109660at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="26"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="235" mass="25343" checksum="845903B5E5B1061B" modified="2011-05-03" version="1">MAWDYIIQGFSEAVKLIDDPYVIEIALRSIKVSGIATLMAVAWSLPISVLLGLKDFPGKWLVKTLINGLMGVPTVIWGLVLYLMFVPLGPLGSLGLLYTEMGISVGQALLITPIIMSIVVNSLESIEGEVRELALTLGADEMRASFQVVRESVGGIVLAIIAAFNRAIAELGIALMIGGNIYVRGGVYNTRVLTTAIQMYTVRAEINMAIALGIILMGIVLAVNLLSNLVRKWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKP4</accession>
    <name>F0LKP4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468174.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84878">
        <property type="protein sequence ID" value="ADT84878"/>
        <property type="gene ID" value="TERMP_01903"/>
    </dbReference>
    <dbReference type="GeneID" id="26137439"/>
    <dbReference type="KEGG" id="tba:TERMP_01903"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1902"/>
    <dbReference type="eggNOG" id="arCOG10117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2340339_0_0_2"/>
    <dbReference type="OMA" id="NTRTIQG"/>
    <dbReference type="OrthoDB" id="108190at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="98" mass="11475" checksum="7EC30A91A2A4541A" modified="2011-05-03" version="1">MGYFAEMLKREFEELNVEEVYTTKLGNRDIEILEVSVYGTKFLAMFQSEEKKHGLYLWSLIITSANNTRTIQGMDKLDTLKMRIKENVRAIMEGMEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKP8</accession>
    <name>F0LKP8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methanol dehydrogenase regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468178.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01907"/>
    <dbReference type="EnsemblBacteria" id="ADT84882">
        <property type="protein sequence ID" value="ADT84882"/>
        <property type="gene ID" value="TERMP_01907"/>
    </dbReference>
    <dbReference type="GeneID" id="10042223"/>
    <dbReference type="KEGG" id="tba:TERMP_01907"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1906"/>
    <dbReference type="eggNOG" id="arCOG00434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_2"/>
    <dbReference type="OMA" id="FMARVSI"/>
    <dbReference type="OrthoDB" id="49734at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="40"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="237"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="317" mass="36096" checksum="9427B9F9AA9A3FB0" modified="2011-05-03" version="1">MKIEEVHEKGKLILNEVGKAIVGKEEVLKLILTTILADGHILIEDLPGLAKTLMAKSFATALGVKFRRVQFTPDLLPSDILGVSVFNQKTLEFEFRKGPIFTNILLADEINRAPPKTQSALLEAMQERQVTIEGKTYYLDRPFVVIATQNPIEQEGTYPLPEAQLDRFLVRLRVGYPTKQEEIEILRRRIERKKEEVDINPIVTPEEVVEMQKAVEDVYVSDAVLEYITDIVKATRENKREIDIGASPRGSLALLKLSRAYAALEGRDYVIPDDVKKVAVPALSHRLILKRELWYTRVSQESVMQRILEKIPVPKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKR9</accession>
    <name>F0LKR9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease HII</fullName>
            <shortName evidence="10">RNase HII</shortName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rnhB</name>
        <name evidence="13" type="ordered locus">TERMP_00671</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10 11">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 10 11">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00671"/>
    <dbReference type="EnsemblBacteria" id="ADT83648">
        <property type="protein sequence ID" value="ADT83648"/>
        <property type="gene ID" value="TERMP_00671"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00671"/>
    <dbReference type="eggNOG" id="arCOG04121">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_0_4_2"/>
    <dbReference type="OMA" id="REECRFF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_A">
        <property type="entry name" value="RNase_HII_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020787">
        <property type="entry name" value="RNase_HII_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00729">
        <property type="entry name" value="TIGR00729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="12">
        <location>
            <begin position="8"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT83648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="227" mass="25952" checksum="6E23E13AC28A37C0" modified="2011-05-03" version="1">MSRMKLGGIDEAGRGPVIGPLVIAAVVIDEKNLSKLEALGVRDSKKLTPRRREKLFNEIIELLDDYAIIELSPEQIDEREGTMNEFEIENFVRVLNSLKVKPDVLYIDAADIKEKRFGEIIGKGLNFSPKIIAEHKADAKYLPVSAASILAKVTRDKAIEKLKKQYGEIGSGYPSDPRTRKFLEEYYKEHGEFPPIVRKSWKTLRKIEEKLKAQTQRKQKNLLDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKS1</accession>
    <name>F0LKS1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ZnuC-like Zinc ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466948.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00673"/>
    <dbReference type="EnsemblBacteria" id="ADT83650">
        <property type="protein sequence ID" value="ADT83650"/>
        <property type="gene ID" value="TERMP_00673"/>
    </dbReference>
    <dbReference type="GeneID" id="10040991"/>
    <dbReference type="KEGG" id="tba:TERMP_00673"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.674"/>
    <dbReference type="eggNOG" id="arCOG00201">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_2"/>
    <dbReference type="OMA" id="SVWDVVM"/>
    <dbReference type="OrthoDB" id="87509at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="262" mass="29116" checksum="CACBD22A8E711778" modified="2011-05-03" version="1">MEAVISENVSIYYGNYEAVKGLTFKLHEGETLLLMGPNGAGKTTLLRTLAGFHKEYTGKLSIFGKPPHESKDLISYVPQSHYLNERVPLTVLEVVAMGQIYKKSFVHFKIPKEILKSAEEALSFVGLESIKDKLFKELSGGQKQRVLLARALISNPKLLLLDEPLSALDPSARAEVAGILNKIKKERGITMIITTHDVNPLTEIGDKVMLLNRELIAFGTPPEVLRDEIISRVYGSLSKAVRVGDKLYCIIGDVHIHRGERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKS6</accession>
    <name>F0LKS6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00678"/>
    <dbReference type="EnsemblBacteria" id="ADT83655">
        <property type="protein sequence ID" value="ADT83655"/>
        <property type="gene ID" value="TERMP_00678"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00678"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.679"/>
    <dbReference type="eggNOG" id="arCOG05114">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142246_0_0_2"/>
    <dbReference type="OMA" id="PYIGIGN"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="150" mass="16518" checksum="0F3C5A2D3C515CE9" modified="2011-05-03" version="1">MTIEVPNYGKIEARAVVFDLNGTLGVEGRVSEEVKRLLERLSEKYIVVVLSADTFGTLEEEFKGLNVKIERVRDGNDKLEKAMKYEPYIGVGNGNNDVRMLENAELAFCVVGEEGATVDALLASDIVVKDVKDAIAMLLNEKKLIATLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKX6</accession>
    <name>F0LKX6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Deblocking aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_00728</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467003.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00728"/>
    <dbReference type="MEROPS" id="M42.003"/>
    <dbReference type="EnsemblBacteria" id="ADT83705">
        <property type="protein sequence ID" value="ADT83705"/>
        <property type="gene ID" value="TERMP_00728"/>
    </dbReference>
    <dbReference type="GeneID" id="10041046"/>
    <dbReference type="KEGG" id="tba:TERMP_00728"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.730"/>
    <dbReference type="eggNOG" id="arCOG01519">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_0_1_2"/>
    <dbReference type="OMA" id="FMAHMDE"/>
    <dbReference type="OrthoDB" id="27966at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="333" mass="36837" checksum="21CF142E467A8D2C" modified="2011-05-03" version="1">MEHLTKELKEITQIPGISGYEEKVREKLIEWIEPFADYKVDRIGNLIVELGEGKEKAVFMAHIDEIGLLITGITNNGKLKFRKIGGIDDRLLIGRHVDVITENGKLDGIIGVTPVHLNLERKFDTIPWHALEIDIGAESKEEALSLGVKPLDYAVFKKHFAVLNKRYVATRSLDDRFGAVALFEAIKDLVDHDLNGKFIFAFTVQEEIGLKGAKFLAEHYSPEFAFAIDSFACCSFLTGDVKLGSGAVVRAVDNSAVYTRKLAKRVVGIAEKNGIPLQIGVTGGGTDASVFQHKSEVLALSVPIKYLHSEVEMLHLDDLDALIKLIEAIVFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKZ2</accession>
    <name>F0LKZ2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468195.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84899">
        <property type="protein sequence ID" value="ADT84899"/>
        <property type="gene ID" value="TERMP_01924"/>
    </dbReference>
    <dbReference type="GeneID" id="10042240"/>
    <dbReference type="KEGG" id="tba:TERMP_01924"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1923"/>
    <dbReference type="eggNOG" id="arCOG03808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096716_0_0_2"/>
    <dbReference type="OMA" id="YSQYVIE"/>
    <dbReference type="OrthoDB" id="55528at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="244" mass="28350" checksum="A530F040726691DA" modified="2011-05-03" version="1">MELLKTGIEKLDEAIGGGLLEDSVMLIIYDTYSMGWALGVKILQNRIDRGDFGVIINSVLPLSSLSMEFKIANFDIYETSRTGNLGIIDIFASFNKIQYTEPFVYYTDMDTSTFLPKFIALYRRMLSEMIKDRRPVGLAVTMDGLAFLLGEEQYIRILQKNAAIKETARIKESRKRPLNVFLVNRDRVSRRFISWLALYSQYIIEFYSLEEGNEEKMVVRKSPLPEFEPRTYKFRLKKGEVMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL19</accession>
    <name>F0LL19_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA (Uracil54-C5-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468222.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01951"/>
    <dbReference type="EnsemblBacteria" id="ADT84926">
        <property type="protein sequence ID" value="ADT84926"/>
        <property type="gene ID" value="TERMP_01951"/>
    </dbReference>
    <dbReference type="GeneID" id="10042267"/>
    <dbReference type="KEGG" id="tba:TERMP_01951"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1950"/>
    <dbReference type="eggNOG" id="arCOG00122">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_8_1_2"/>
    <dbReference type="OMA" id="FYAGDMK"/>
    <dbReference type="OrthoDB" id="25398at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="6">
        <location>
            <begin position="272"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="417" mass="47757" checksum="56A62605EB53DF11" modified="2011-05-03" version="1">MRGEIKKLSEEGFGIIKAGKKKVYVPFAAVGDVVEIKKWHREKKKLVAHEYEIIMPSPIRTEPKCPYFGKCGGCVLQHLPYSEQIKFKAEKLENLLGYAVDVIPSPKIYGHRNRIDVVISTEGIGFRRRGTWWDVVDIEKCIVFGEKSGRALKSLREFIEDFKLQPWNLRKSEGFMRYIVMREGKFTGELMINLVTYEGSLPDEVQEYFSFADSIYWSVNSSKSDVSYGEPRKFWNREFIKERLDDVVYLIHPNSFFQTNSYQAVNLVKKVAEFAEGKKVLDLYSGVGTFGIYLAKKGFEVEGIEINPFAVEMARKNAEINNVDAKFYVGEDKSVGNLGKYDTIVVDPPRAGLHPKLIRKMLKDAPEIIVYVSCNPKTLAKNLEELKSIYKVEEIIGLDMFPHTPHVEVVTKLKLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL26</accession>
    <name>F0LL26_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type II methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468229.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01959"/>
    <dbReference type="REBASE" id="29889">
        <property type="entry name" value="M.TbaMPORF1959P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84933">
        <property type="protein sequence ID" value="ADT84933"/>
        <property type="gene ID" value="TERMP_01959"/>
    </dbReference>
    <dbReference type="GeneID" id="10042274"/>
    <dbReference type="KEGG" id="tba:TERMP_01959"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1957"/>
    <dbReference type="eggNOG" id="arCOG00115">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_5_1_2"/>
    <dbReference type="OMA" id="WRKANPM"/>
    <dbReference type="OrthoDB" id="63009at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="312" mass="36755" checksum="A19989C44569D9C7" modified="2011-05-03" version="1">MIIDEIILGDCLEWIPKLKGVHLSFLDPPFNQGKEYRFFNDNLSEEEYWGWMKEVVREIYKVTEKGGAIYFMQREKNTEWVLRILRETGWTLQNLIIWKKMASAVPQRYRFNKAYQIIAFATKGKKPRVFNKLRVDYPLAPWHKYPRENGIYLTDVWDDIRELTSGYFAGDEPLRDESGKRIHLQQSPVALLLRIILSSTMPGDLVLDPFAGTGTTLVVAKQLKRHYVGIEIDPHYVEVIKKRLSKLRKADDISRYREYYRFTENLEKIWPMPEKPLKIPKQKTLLDVELSKHSKHILKDGRATGIEENQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL56</accession>
    <name>F0LL56_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase_S24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01989</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01989"/>
    <dbReference type="MEROPS" id="S26.A11"/>
    <dbReference type="EnsemblBacteria" id="ADT84963">
        <property type="protein sequence ID" value="ADT84963"/>
        <property type="gene ID" value="TERMP_01989"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01989"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1986"/>
    <dbReference type="eggNOG" id="arCOG01740">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037192_0_0_2"/>
    <dbReference type="OMA" id="WTVHRVY"/>
    <dbReference type="OrthoDB" id="84567at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027245">
        <property type="entry name" value="Sec11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="PTHR10806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="PTHR10806:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="5">
        <location>
            <begin position="35"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="353" mass="39820" checksum="9AF8177DFC5E67D4" modified="2011-05-03" version="1">MRLLELLFTFVVGVILISSVIGIVLDRPVLISYAYSDSMSPTIEKGDLFFINPFSKGDVGDIIVFRMKDEWTVHRVYAKDEEGYITKGEQQCRNRPAGENPKISKESVIGTVVTLGRTPIKIPRAGNYIQDLSKKGSNLYIAVALLVIGAILMTTGGERKRRKKRRRYIKVKFKTVYAITASLVLVTLLISMMLSWGTLAFSYSSTLAGGQQKGWYMPGSTFEENLTIKNRAIYPFLYFVEAKGNRIEITSENSFKIPGRSEKAITIRVNVPEETRVYGEKIEIYAYLPILPERVIAELYSKSPYLPFVAYIVEASIFLILLYFAIGAGSEDIIRYRVHRSGIFDKLKESVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL79</accession>
    <name>F0LL79_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467028.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00753"/>
    <dbReference type="EnsemblBacteria" id="ADT83730">
        <property type="protein sequence ID" value="ADT83730"/>
        <property type="gene ID" value="TERMP_00753"/>
    </dbReference>
    <dbReference type="GeneID" id="10041071"/>
    <dbReference type="KEGG" id="tba:TERMP_00753"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.755"/>
    <dbReference type="eggNOG" id="arCOG01860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_3_1_2"/>
    <dbReference type="OMA" id="GHDWFHI"/>
    <dbReference type="OrthoDB" id="62777at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="34"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="204" mass="23332" checksum="FB31796AD51AD304" modified="2011-05-03" version="1">MRIEDFIKDEKSLTIIKKAEEFAKNFFEREGTHGFSHTERVLALCMHIGKKEGADLEVLALAALLHDIARPLESKGKIEDHAKEGAKIARRFLKGLGYEKTDQVAHAIEAHRFSKPPEPQTLEAKILSDADKLDAIGAIGIARVFMYSGEHGRSIEYSLKHFEEKILKLKDLMYTKTAKEMALERHKYVEEFIDRIRKEIEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL90</accession>
    <name>F0LL90_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83741">
        <property type="protein sequence ID" value="ADT83741"/>
        <property type="gene ID" value="TERMP_00764"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00764"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.766"/>
    <dbReference type="eggNOG" id="arCOG05818">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1998844_0_0_2"/>
    <dbReference type="OMA" id="AFGIMKF"/>
    <dbReference type="OrthoDB" id="111509at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="124" mass="14469" checksum="E61136A67D3BA9D3" modified="2011-05-03" version="1">MIIERIKLKAELTEEQYERAIKLVEKLKSTFANVLVKKFKTQEKISFIDVDLGVRLNFDVIIGNRGKPFIAVEMGGNKSKYAFQIMKFFLDELGVEYSFDFDGKEVYDTLKRRIKAKSLLDYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL94</accession>
    <name>F0LL94_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase (ADP-forming) beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467043.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00768"/>
    <dbReference type="EnsemblBacteria" id="ADT83745">
        <property type="protein sequence ID" value="ADT83745"/>
        <property type="gene ID" value="TERMP_00768"/>
    </dbReference>
    <dbReference type="GeneID" id="10041086"/>
    <dbReference type="KEGG" id="tba:TERMP_00768"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.770"/>
    <dbReference type="eggNOG" id="arCOG01338">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063044_1_1_2"/>
    <dbReference type="OMA" id="FGPAIMF"/>
    <dbReference type="OrthoDB" id="65977at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="232" mass="25853" checksum="D7BE3E25EAE5F379" modified="2011-05-03" version="1">MDRVSKAREIIEKAKAEGRPLVEPEAKEILKLYGIPTPDFKVARNEEEAVKFAREIGYPVVMKIVSPQIIHKSDAGGVKINIKNDDEAREAFRTIMENAKRYKPDADLWGVIIYKMLPLGKEVIVGMIRDPQFGPAVMFGLGGIFVEILKDVSFRVAPITKEEALEMIKEIKAYPILAGARGEKPVNIEALADIIVKVGELALELPEVKELDINPIFAYEDEAVAVDARMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLB8</accession>
    <name>F0LLB8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00792"/>
    <dbReference type="EnsemblBacteria" id="ADT83769">
        <property type="protein sequence ID" value="ADT83769"/>
        <property type="gene ID" value="TERMP_00792"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00792"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.794"/>
    <dbReference type="eggNOG" id="arCOG05742">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2165360_0_0_2"/>
    <dbReference type="OMA" id="HYSMPPG"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="106" mass="12207" checksum="5BF5946E8298E4EA" modified="2011-05-03" version="1">MNIFKSKKKKNGVLEQKITEDAYEDLKALLMRAKPEVEEDRIVLKLPRGDVILTKDSLRIIAESREDAEKILRNLHHYSMPPGLWPAYGLSYSIKRDSAVLRKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLH6</accession>
    <name>F0LLH6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">GMP synthase [glutamine-hydrolyzing] subunit B</fullName>
            <ecNumber evidence="5 12">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">GMP synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">guaAB</name>
        <name evidence="15" type="ordered locus">TERMP_02031</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="5 12"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468301.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02031"/>
    <dbReference type="EnsemblBacteria" id="ADT85005">
        <property type="protein sequence ID" value="ADT85005"/>
        <property type="gene ID" value="TERMP_02031"/>
    </dbReference>
    <dbReference type="GeneID" id="10042346"/>
    <dbReference type="KEGG" id="tba:TERMP_02031"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2028"/>
    <dbReference type="eggNOG" id="arCOG00085">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_0_2"/>
    <dbReference type="OMA" id="EGGIKSH"/>
    <dbReference type="OrthoDB" id="31932at2157"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00345">
        <property type="entry name" value="GMP_synthase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
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    <dbReference type="InterPro" id="IPR026598">
        <property type="entry name" value="GMP_synthase_B"/>
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    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
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        <property type="entry name" value="NAD/GMP_synthase"/>
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    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
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    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="27"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADT85005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="307" mass="34484" checksum="41A3CBE0AE0E5BB0" modified="2011-05-03" version="1">MWESFIEEKVKEIREKVGDGKAIIALSGGVDSSTAAILAHKAIGDKLYAVFVNTGFLRKGEPEFVIKTFRDEFGLNLIYVDAQERFFNALKGIVDPEQKRKIIGKVFIDVFEEVAKEIDAEFLIQGTIAPDWIESKGKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVREVAKELGLPEKIYNRMPFPGPGLAVRVLGEVTPEKVAIVREANAIVEEEVEKAKLRPWQAFAVLLNVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRMAFRITSEIPQVGRVLYDITNKPPATIEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLM1</accession>
    <name>F0LLM1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="10" type="ordered locus">TERMP_00821</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00821"/>
    <dbReference type="EnsemblBacteria" id="ADT83798">
        <property type="protein sequence ID" value="ADT83798"/>
        <property type="gene ID" value="TERMP_00821"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00821"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.823"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="RMWQRRM"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="123"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="217"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="306" mass="34518" checksum="EB4AA79E0D101B66" modified="2011-05-03" version="1">MISAEDFKKCPVCGSVRLIYDPERGEIVCTACGYVVAQNIIDSGPEWRAFDADQRVKRGRVGAPMTMMIHDKGLSSTIDWKNKDIHGHDISGTMRAKMYRLRKWQRRIRVSDAAERNLAFALSELDRMASQLGLPRNIKEMAAALYRKAVMERLIRGRSIEGVTAACLYAACRMAKVPRTLDEIEEVARVDKKEIGRSYRFIARELHLRLTPTSPIDYVSRFADQLGLSERTKNRAVKILQKAIKLGLTSGRGPMGVAAAALYIASVLEGEKKTQREVAEVAHVTEVTVRNRYKELVERLNIRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLN8</accession>
    <name>F0LLN8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaredoxin/thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467113.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00838"/>
    <dbReference type="EnsemblBacteria" id="ADT83815">
        <property type="protein sequence ID" value="ADT83815"/>
        <property type="gene ID" value="TERMP_00838"/>
    </dbReference>
    <dbReference type="GeneID" id="26136287"/>
    <dbReference type="KEGG" id="tba:TERMP_00838"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.841"/>
    <dbReference type="eggNOG" id="arCOG01218">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_20_2_2"/>
    <dbReference type="OMA" id="CDDIEVK"/>
    <dbReference type="OrthoDB" id="110723at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="33"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="116" mass="13153" checksum="81119BF57DAB483F" modified="2011-05-03" version="1">MDELEMIRRKKMLELMKRMGMVEVKPKGPRVVIEVITSPTCPYCPIALQMAKEIARRHPGVIVKELSVATPEGRKKAMEHNILGTPTILINNKVEFIGVPPFVEFERKVKEKLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLU2</accession>
    <name>F0LLU2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468337.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02067"/>
    <dbReference type="EnsemblBacteria" id="ADT85041">
        <property type="protein sequence ID" value="ADT85041"/>
        <property type="gene ID" value="TERMP_02067"/>
    </dbReference>
    <dbReference type="GeneID" id="10042382"/>
    <dbReference type="KEGG" id="tba:TERMP_02067"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2064"/>
    <dbReference type="eggNOG" id="arCOG00717">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115769_0_2_2"/>
    <dbReference type="OMA" id="EATWIET"/>
    <dbReference type="OrthoDB" id="101018at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021799">
        <property type="entry name" value="DUF3368"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11848">
        <property type="entry name" value="DUF3368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="162" mass="17806" checksum="02D9D2D086142A5D" modified="2011-05-03" version="1">MIVVSDSGPLIALAKIGKLNVLMELFGQITIPRAVWIEVVERGKGKPGSDEVKNANWIKVIEVEDKLSVEILRKEIEIGEAEAIVLAKELNANLIILDEKIPRIIAKSLGLTVVGSLAILFIAKKRGIIGEDLDLLINELRTKGVRFSDKVIEELRRMCGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM05</accession>
    <name>F0LM05_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468400.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02130"/>
    <dbReference type="EnsemblBacteria" id="ADT85104">
        <property type="protein sequence ID" value="ADT85104"/>
        <property type="gene ID" value="TERMP_02130"/>
    </dbReference>
    <dbReference type="GeneID" id="10042445"/>
    <dbReference type="KEGG" id="tba:TERMP_02130"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2127"/>
    <dbReference type="eggNOG" id="arCOG05861">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1369570_0_0_2"/>
    <dbReference type="OMA" id="GNECQTD"/>
    <dbReference type="OrthoDB" id="95100at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022121">
        <property type="entry name" value="Peptidase_M73_camelysin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12389">
        <property type="entry name" value="Peptidase_M73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="199" mass="21832" checksum="C65FA8DD8211BD74" modified="2011-05-03" version="1">MKKLLLIVLVAGILIGAAGIQVGNALFSDKSISKGNEISTGEFDIGISKDGSRFYDDLKLFEFSNLKPGDYREFSFYIKNRGDVGVSRILLSLNVEDLEDGKLTDAESLVDNTTDTGELSKNIIIAKLSVTKDSQTYSLDDYVGKTLKEISGKQILLPRDLLKPGENIKVTVGFKLKDDAGNECQTDIARITLNIYAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM13</accession>
    <name>F0LM13_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCA-adding enzyme</fullName>
            <ecNumber evidence="8">2.7.7.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCA tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA CCA-pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA adenylyl-/cytidylyl- transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA-NT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cca</name>
        <name evidence="11" type="ordered locus">TERMP_02138</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">A single active site specifically recognizes both ATP and CTP and is responsible for their addition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02138"/>
    <dbReference type="EnsemblBacteria" id="ADT85112">
        <property type="protein sequence ID" value="ADT85112"/>
        <property type="gene ID" value="TERMP_02138"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02138"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2135"/>
    <dbReference type="eggNOG" id="arCOG04249">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044679_1_0_2"/>
    <dbReference type="OMA" id="DVDLVPC"/>
    <dbReference type="OrthoDB" id="82755at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01264">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008229">
        <property type="entry name" value="CCA-adding_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042090">
        <property type="entry name" value="CCA_tRNA_nucleotrans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006116">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015329">
        <property type="entry name" value="tRNA_NucTransf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39643">
        <property type="entry name" value="PTHR39643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09249">
        <property type="entry name" value="tRNA_NucTransf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005335">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="SSF55003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03671">
        <property type="entry name" value="cca_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0692">RNA repair</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="9">
        <location>
            <begin position="42"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTransf2" evidence="10">
        <location>
            <begin position="153"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT85112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="452" mass="53044" checksum="285A4F79AB29F862" modified="2011-05-03" version="1">MKELLNQVLKEIKPSEEERELVESIKREVEGISKEIIAVFDYDVEPYFVGSLAKDTYLSGDHDIDLFLAFPLEVPLSELREKGLELAKAIGEKLGKYEIAYAEHPYVRAFYRGFKVDLVPCYSVRNWRDVRTAVDRSILHTEWVLKHLNGRNDEVRLLKKFFKGINVYGSEIYVKGFSGYLTELLIIKYGSFLDVLENHEFMLRQKIIDLEGWLKKEPEVAMKTVKREADADVPLIIIDPVDPRRNVASALSWEKFGIFYFKAKQFLEKPSREFFFPRQKQKRDYKKLLRKKETKLVTLLFEKPDLIDDLLLPQLEKSAKGFMKALELRGFKVFEAHWGYKNKAFIMLEVDRTEKPRIGIKPGPEFFTERGLRFYSKNQKVWIRGKRLYSEKVVEESIVDAIRELLEKNQVSLGKQIKEHITQADILINFVPPELSDEAYLFLSREKWNLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM16</accession>
    <name>F0LM16_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KaiC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468411.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02141"/>
    <dbReference type="EnsemblBacteria" id="ADT85115">
        <property type="protein sequence ID" value="ADT85115"/>
        <property type="gene ID" value="TERMP_02141"/>
    </dbReference>
    <dbReference type="GeneID" id="10042456"/>
    <dbReference type="KEGG" id="tba:TERMP_02141"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2138"/>
    <dbReference type="eggNOG" id="arCOG01171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_2_2_2"/>
    <dbReference type="OMA" id="TTFCSQF"/>
    <dbReference type="OrthoDB" id="76011at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="238" mass="27219" checksum="C093E63E8A1207E2" modified="2011-05-03" version="1">MHTSHITRISTGVKGLDELIEGGLIPGRVYLITGPPGSGKTTLAFHFLLEGARHGEKGLYVSLIQKPEDVVKDIAKYDPSIFAYIKTWKIILYDLGPVLWRETEKVPTWSSVLFRIKELSETEKIDRLVIDPVTAIEFSVSNPARKKAELARFIRAIEDLGITAYLIGEMTDMDRYTEEHYLTSGVIMMHYFMHKNRMIRAIQILKMRGTKHDMDMKKVIFSDNGIIVFNKSPFEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM20</accession>
    <name>F0LM20_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00890"/>
    <dbReference type="EnsemblBacteria" id="ADT83867">
        <property type="protein sequence ID" value="ADT83867"/>
        <property type="gene ID" value="TERMP_00890"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00890"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.892"/>
    <dbReference type="eggNOG" id="arCOG05829">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126381_0_0_2"/>
    <dbReference type="OMA" id="MFGVSRD"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="188" mass="21460" checksum="54137462E932BB55" modified="2011-05-03" version="1">MVLKIFQAESANIEECLNHIKTTSKEEFLKTPGKIEKSKISLNFGAFMNVIIALDIDESQPAEKGLITAYASARNKRDALKKLQDALNKQIKSTMEIVDFEIGTYTTPVTRRTYAVGIIVYNIPLHEVEFSKLSIKERRKILAKALELFNYNPKVLNISEVARTFGVSRDSIYYDIEQILKERRLRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM95</accession>
    <name>F0LM95_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468414.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02144"/>
    <dbReference type="EnsemblBacteria" id="ADT85118">
        <property type="protein sequence ID" value="ADT85118"/>
        <property type="gene ID" value="TERMP_02144"/>
    </dbReference>
    <dbReference type="GeneID" id="26137740"/>
    <dbReference type="KEGG" id="tba:TERMP_02144"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2141"/>
    <dbReference type="eggNOG" id="arCOG07107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2191168_0_0_2"/>
    <dbReference type="OMA" id="LSIGGEC"/>
    <dbReference type="OrthoDB" id="104278at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="109" mass="12823" checksum="053F65217C93AD5A" modified="2011-05-03" version="1">MWREQLEKRGYLENDEILIELTIGGECGEYLPSLALYDKATDTWYYFDNDIPPGMTQEEALRNAVEFFERIVIGLEKPKLKISPIREAPKEVYEKFEKFLQGLRNEGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMC4</accession>
    <name>F0LMC4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multi antimicrobial extrusion protein (Na(+)/drug antiporter)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02173"/>
    <dbReference type="EnsemblBacteria" id="ADT85147">
        <property type="protein sequence ID" value="ADT85147"/>
        <property type="gene ID" value="TERMP_02173"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02173"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2168"/>
    <dbReference type="eggNOG" id="arCOG01731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_2"/>
    <dbReference type="OMA" id="TGNQKVG"/>
    <dbReference type="OrthoDB" id="52466at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="466" mass="51489" checksum="C4E49D9AB043E833" modified="2011-05-03" version="1">MTPKIHEMRQEIVEGNIEKTLFRLAWPLIVNNIIQVLYNITDTFWLGRLGREALSAPGVAWPLIGTLMSLGMGFATAGFAFVGQYIGAEEYKKAERAAGAVYSLMFIFASIVAVVGYLIVPYALRFMKVTENVYPHSLSYTRIIFIGIPFAFSFMAFSFLMRATGDTKTPVKISFFTVGLNIILDPILIFGLFGFPKLGVAGAALATIISNTTGSIIGMYLLLAGKVGIHLTKEDLKPDLRFYARIFKVGLPSSIGSSANSFGFVILTRIIFGFGDITYAAYTITTRLVNFLTSISRGISMAMGTMIAQNIGAEKYERAKKIAERTMMVNFTIASIAILLIGIFRVQVFRVFLNDPAVIAESAIVLKYFLISVPFFNGIFMVVDNVFRSSGHTKKSMVLGILRLWGLRIPLSYILGYHIFMSSKGVFLGMGLSNFIASGVGLLWFLKGSWMKRIIEEDIRRSGSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMC5</accession>
    <name>F0LMC5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoenolpyruvate synthase</fullName>
            <shortName evidence="7">PEP synthase</shortName>
            <ecNumber evidence="7">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_02174</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 7">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468444.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02174"/>
    <dbReference type="EnsemblBacteria" id="ADT85148">
        <property type="protein sequence ID" value="ADT85148"/>
        <property type="gene ID" value="TERMP_02174"/>
    </dbReference>
    <dbReference type="GeneID" id="10042489"/>
    <dbReference type="KEGG" id="tba:TERMP_02174"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2169"/>
    <dbReference type="eggNOG" id="arCOG01111">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007308_6_2_2"/>
    <dbReference type="OMA" id="RRFVQMY"/>
    <dbReference type="OrthoDB" id="3139at2157"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01418">
        <property type="entry name" value="PEP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="9">
        <location>
            <begin position="18"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="8">
        <location>
            <begin position="380"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="10">
        <location>
            <begin position="472"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT85148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="788" mass="87385" checksum="487935E1872331AB" modified="2011-05-03" version="1">MAYKFIKWFEELSKEDVALVGGKGANLGEMTRAGIPVPPGFCVTAEAYKYFVENVKVEDGRTLQEWIMDVISKTNVDDSKQLQENTAKIREKIISLPMPEEIAEEIKQAYKELSQRFGKDEVYVAVRSSATAEDLPDASFAGQQETYLDVIGAEDVIKHVQKCWASLWTARATFYREKQGFDHMKVYLSAVVQKMVNSEKSGVMFTANPVTNNRNEIMINASWGLGEAVVSGSVTPDEYIVEKGTWKIKEKFIAKKEVMVVRNPETGKGTVYVKVADYLGPEWVEKQVLTDEQIIEVAKIGAKIEEHYGWPQDIEWAYDKDDGKLYIVQSRPITTLKEEVTGEEVEEAEEAEVILKGLGASPGIGAGRVVVIFDASEIDKVKEGDILVTTMTNPDMVPAMKRAAAIVTDEGGRTSHAAIVSRELGIPCVVGTKEATKKLKTGDYVTVDGTRGVVYKGIVKSLVKKEKEEKAEGKVVVAGAPLVTGTMVKVNVSMPEVAERAAATGADGVGLLRAEHMILTIGQHPIKFIKEGKFDELVERLADGIRTVAAAFYPRPVWYRTLDAPTNEFKEMPGGEDEPDERNPMLGWRGIRRSLDQPELLKAEFTAIKKVVEEGYNNVGVMLPLVSHPYQIREAKRIAREVGLEPHKDVAFGVMIEVPAAALIIEDLIKEGIDFVSFGTNDLTQYTLALDRDNERVAKLYDETHPAVLKLIKHVIKVCKKYGVETSICGQAGSDPKMARILVRLGIDSISANPDAVELIRKVVAQEERKIMLEAARKQIFKDEEDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMD9</accession>
    <name>F0LMD9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02188"/>
    <dbReference type="EnsemblBacteria" id="ADT85162">
        <property type="protein sequence ID" value="ADT85162"/>
        <property type="gene ID" value="TERMP_02188"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02188"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2183"/>
    <dbReference type="HOGENOM" id="CLU_3178774_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="46" mass="5587" checksum="51E890231928F14E" modified="2011-05-03" version="1">MHALWRLFFDSFQTTTRLVKSRFWFIKVAEKKRALMNTNIHFLAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMI1</accession>
    <name>F0LMI1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intracellular protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467258.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00984"/>
    <dbReference type="MEROPS" id="C56.001"/>
    <dbReference type="EnsemblBacteria" id="ADT83960">
        <property type="protein sequence ID" value="ADT83960"/>
        <property type="gene ID" value="TERMP_00984"/>
    </dbReference>
    <dbReference type="GeneID" id="26136433"/>
    <dbReference type="KEGG" id="tba:TERMP_00984"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.987"/>
    <dbReference type="eggNOG" id="arCOG00769">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_4_2"/>
    <dbReference type="OMA" id="YAWMREF"/>
    <dbReference type="OrthoDB" id="98884at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="166" mass="18605" checksum="C29AAB6ECD71792F" modified="2011-05-03" version="1">MKVLFLSADDFEDIELIYPLHRIREEGHEVIIASNKKDYITGKHGYRVKVDLTFDEVDPDEFDALVLPGGKAPERVRINEKAVAIARKMFSDGKPVATICHGPQILISAGVLKGRKGTCVITIKDDLINAGAEFIDKEVVVDGNWVSSRHPGDLYAWMREFVKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMJ3</accession>
    <name>F0LMJ3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4157 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00996"/>
    <dbReference type="EnsemblBacteria" id="ADT83972">
        <property type="protein sequence ID" value="ADT83972"/>
        <property type="gene ID" value="TERMP_00996"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00996"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.999"/>
    <dbReference type="eggNOG" id="arCOG02980">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060689_0_0_2"/>
    <dbReference type="OMA" id="MFPELYL"/>
    <dbReference type="OrthoDB" id="11006at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025295">
        <property type="entry name" value="DUF4157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13699">
        <property type="entry name" value="DUF4157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4157" evidence="1">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="372" mass="42677" checksum="670711BC45048DD3" modified="2011-05-03" version="1">MRKKSGLITLTLIIILIASFYQIRVGSIDERAKQVLQKVQEIESEVQEIRNLSFKESPKIIVITRQEALKKWGPSEENIYELRMWEAIYKMTFLVPPSYNLTKEKKEQTASWIAATIGNKVYIIEENFLESGETAYRVVAHELTHVLQKQNFNAPYSGPTLDSTLAIRALVEGDADLVADLYCKRHYIPIEKITALYLEDPVWSLNAFPYVFGDKFVQYLYEKGGWGLVNSAYSKLPVTTQQVMNPEMYLSYTLPENVSLSVRNGGVLHEDTMGEFYVYLLLLVNNYEEKEAKEIADGWRGDKLILAQNSTSLILAWKTAWRDESSAEKFYAALKTIGDNYIKAHPEFGLSFTIKQEGRYVMFTAVRRLKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LML0</accession>
    <name>F0LML0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01013"/>
    <dbReference type="EnsemblBacteria" id="ADT83989">
        <property type="protein sequence ID" value="ADT83989"/>
        <property type="gene ID" value="TERMP_01013"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01013"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1016"/>
    <dbReference type="eggNOG" id="arCOG02008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100105_0_0_2"/>
    <dbReference type="OMA" id="PHYYVSW"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="169" mass="18992" checksum="8815B539F8D9A40B" modified="2011-05-03" version="1">MAVFIHRSWWSLTDNAISDLGKVNLPYNWVMNVSLVVAAILGIYYALGLFKEAKHPTMKLGIWIFILGLMFLAGIGIFPEGTSPHYYVSWGFFITASFGMLVAGIGLYLGREKQLGIITAIIFVLSWILGLWAMKVFRGVAVSEFIGIFGIIAWHYMVLAKILRKEKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LML5</accession>
    <name>F0LML5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467292.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83994">
        <property type="protein sequence ID" value="ADT83994"/>
        <property type="gene ID" value="TERMP_01018"/>
    </dbReference>
    <dbReference type="GeneID" id="26136468"/>
    <dbReference type="KEGG" id="tba:TERMP_01018"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1021"/>
    <dbReference type="eggNOG" id="arCOG07136">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2597929_0_0_2"/>
    <dbReference type="OMA" id="RDIHFFP"/>
    <dbReference type="OrthoDB" id="131002at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="79" mass="9152" checksum="4F3CE2392D28D03C" modified="2011-05-03" version="1">MKIVELDIRLPYDKRGKVLSRLCDRVRGKIKDIHFFPPTASGISEIRMEVETENVQKLLQDLKRIIKEGKISFKVLAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMM8</accession>
    <name>F0LMM8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467305.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01031"/>
    <dbReference type="EnsemblBacteria" id="ADT84007">
        <property type="protein sequence ID" value="ADT84007"/>
        <property type="gene ID" value="TERMP_01031"/>
    </dbReference>
    <dbReference type="GeneID" id="10041348"/>
    <dbReference type="KEGG" id="tba:TERMP_01031"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1034"/>
    <dbReference type="eggNOG" id="arCOG05805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166568_0_0_2"/>
    <dbReference type="OMA" id="RDKEFMM"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="108" mass="13015" checksum="583F26C128A9072E" modified="2011-05-03" version="1">MEIILPKEKFKELKKLDETGIIKLIEENLEKAEETLKAERESFLNEKKAKLEEKLKEIEEQLEALEMFYEKALKDKEFMREMSEKLRKENAALRKELEEKKRALENKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMN7</accession>
    <name>F0LMN7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Putative toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ordered locus">TERMP_01040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467314.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01040"/>
    <dbReference type="EnsemblBacteria" id="ADT84016">
        <property type="protein sequence ID" value="ADT84016"/>
        <property type="gene ID" value="TERMP_01040"/>
    </dbReference>
    <dbReference type="GeneID" id="10041357"/>
    <dbReference type="KEGG" id="tba:TERMP_01040"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1043"/>
    <dbReference type="eggNOG" id="arCOG02225">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_3_2_2"/>
    <dbReference type="OMA" id="ISWADEP"/>
    <dbReference type="OrthoDB" id="104470at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="125" mass="14029" checksum="B2D8F3D475B3101A" modified="2011-05-03" version="1">MHLVDTDIIIDILRGVKGSKEFLLDLSKEGLFLSVISMAEIFSGKETRDPVKHEKILRFLSHFEVVPLTQEIAILGGAIRRDYQIGLADALIAATAIHNGLTIVTYNTKHFEKVEGLKILKPDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMS0</accession>
    <name>F0LMS0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467347.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01073"/>
    <dbReference type="EnsemblBacteria" id="ADT84049">
        <property type="protein sequence ID" value="ADT84049"/>
        <property type="gene ID" value="TERMP_01073"/>
    </dbReference>
    <dbReference type="GeneID" id="10041390"/>
    <dbReference type="KEGG" id="tba:TERMP_01073"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1076"/>
    <dbReference type="eggNOG" id="arCOG04066">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1217517_0_0_2"/>
    <dbReference type="OMA" id="MATPWHL"/>
    <dbReference type="OrthoDB" id="109188at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009185">
        <property type="entry name" value="Nucleotidl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005928">
        <property type="entry name" value="Nucleotidltrnsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="235" mass="27430" checksum="3CA986D6C513DBD6" modified="2011-05-03" version="1">MPREKVVRVWDEREIVYSPKRWRYLWEKREKALQIMERLAQFDPHVYGSVARGDVRKDSDIDIVIPYKVPSYLIELALEGISIQARRIVMATPWHLIKGHIEIDEETTVTFFLTNPTDKELEFYKWGGMVDIWGVKTKQRVPGVNKKLILIIPTEKGHIEREVVGRESEVAKIIGVSVELVKERVHILTRRDAIGRTGVYLNEEVPDWMSFEEALKMIADRDPNIRRKVRESGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMS6</accession>
    <name>F0LMS6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84055">
        <property type="protein sequence ID" value="ADT84055"/>
        <property type="gene ID" value="TERMP_01079"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01079"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1082"/>
    <dbReference type="eggNOG" id="arCOG01204">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2646107_0_0_2"/>
    <dbReference type="OrthoDB" id="63356at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="76" mass="8623" checksum="B00DA25E4E684D87" modified="2011-05-03" version="1">MSIKPNWQSALNKFLKDWKDKDFVEAALLTGNHAVGVQTKYSDVDVYIVLSDKVDWRKRGIVIDGVLIEYLANPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMU2</accession>
    <name>F0LMU2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps19e</name>
        <name evidence="5" type="ordered locus">TERMP_01095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in maturation of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467369.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01095"/>
    <dbReference type="EnsemblBacteria" id="ADT84071">
        <property type="protein sequence ID" value="ADT84071"/>
        <property type="gene ID" value="TERMP_01095"/>
    </dbReference>
    <dbReference type="GeneID" id="26136550"/>
    <dbReference type="KEGG" id="tba:TERMP_01095"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1098"/>
    <dbReference type="eggNOG" id="arCOG01344">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108559_1_0_2"/>
    <dbReference type="OMA" id="YIDGPVG"/>
    <dbReference type="OrthoDB" id="92409at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01474">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_S19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027548">
        <property type="entry name" value="Ribosomal_S19e_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_S19e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="PTHR11710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="150" mass="17337" checksum="7326B42F62282535" modified="2011-05-03" version="1">MATVYDVPGDLLVERVAQKLKEIPEIKPPEWAPFVKTGRHKERLPEQEDWWYYRVASVFRKIYIDGPVGIERLRTWYGGRKNRGHAPEKFYKGSGSIIRKALQQLEAAGFIEKVPGKGRIVTPKGRSFLDKAATELKKELEEVIPELKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN19</accession>
    <name>F0LN19_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467446.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01172"/>
    <dbReference type="EnsemblBacteria" id="ADT84148">
        <property type="protein sequence ID" value="ADT84148"/>
        <property type="gene ID" value="TERMP_01172"/>
    </dbReference>
    <dbReference type="GeneID" id="25394635"/>
    <dbReference type="KEGG" id="tba:TERMP_01172"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1175"/>
    <dbReference type="eggNOG" id="arCOG02559">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_304770_0_0_2"/>
    <dbReference type="OMA" id="SDFWVLR"/>
    <dbReference type="OrthoDB" id="6784at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027552">
        <property type="entry name" value="CGP_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013431">
        <property type="entry name" value="Delta_60_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17164">
        <property type="entry name" value="DUF5122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04288">
        <property type="entry name" value="CGP_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02608">
        <property type="entry name" value="delta_60_rpt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="933" mass="101858" checksum="3DB25295ED70FF19" modified="2011-05-03" version="1">MTISNKLLAFLLIFLFLTFVPYTKGSNDYWIMKYTYKENPDLLLEFGKGALRSARYENGDIVMVETIPMSKTRFDFAVSLVSQDGEVKWTKLYGSKKDDEILAVAILKNGDILLAGWSGYPRDGLVVCLDPNGNIKWSKLIGGKESDEIRAVDVAPDGSIILVGETYSETSTQSLWVIKLKPDGKLKWHRVFQLYEKDHYQSVTGLSVKVSSGGSILVGGVSKQRTAFLAKLTENGSVRWAREYTISESGEGIYGIEVLEDGTILTAGEYYTTTANLFLMKLNGEGQVLWKKGYGSKYGKNERNTEFYNIVLTTDGDILIAGRSEQLDISAGHGVLIHADKNGNLKSWWSMKQFVSVRAIYVDGKDIIAYGSGWKKTSVLAVFPLEGSFECFEESDVEVTSKPLTVKTSKINLKGKAVQFAYKNAGINVTGKIELIGEELCRSKGDMEETQTSTTPREVSTPTEENYWVKSLIGIGDDEITDTAITAEGDIIAVGTTTSFGENGDVLVMRLSSKGEILWQKVYGGKGDDSAHAVAVTNNGEIIVVGQTNSFGAGDYDVWILGLDKNGNVRWQSTYGGEYGEGGLDVDLFTNGDILVVGYTGGFGAGNFDAWVLRLDPVGNIRWQRVYGGSGEDIAWGVKAVNGGTEIVVVGYTKSFNAKGEDGWIMYLDGNGNIKWQKMIGSDKDDEFLAVSEDADGNIVVAGMLTGKDDYEKGWVVKLNKRGKVLWQGAYGGEEYGDAFFDIDTAGDRITVVGGTQNFGTEETGSWVLHLDSSGNIINEFVCEEGDSMLWSVATDESSTVAVGYSTVEGKDIFIMKLPKDGNLECTICRSSEAIVRTPAIIIRDSKAVSENTKGIMKESRGTVDVSDFKEKVNCPAEEIKETKHREISSSESPSEVTPIQSPEEESTKGICGPGVFAVLAILGKIIRKRKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN25</accession>
    <name>F0LN25_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease III</fullName>
            <ecNumber evidence="10">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nth</name>
        <name evidence="12" type="ordered locus">TERMP_01178</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="10"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467452.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01178"/>
    <dbReference type="EnsemblBacteria" id="ADT84154">
        <property type="protein sequence ID" value="ADT84154"/>
        <property type="gene ID" value="TERMP_01178"/>
    </dbReference>
    <dbReference type="GeneID" id="10041495"/>
    <dbReference type="KEGG" id="tba:TERMP_01178"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1181"/>
    <dbReference type="eggNOG" id="arCOG00459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_4_2"/>
    <dbReference type="OMA" id="QIIWYGR"/>
    <dbReference type="OrthoDB" id="124734at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="11">
        <location>
            <begin position="53"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT84154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="236" mass="27186" checksum="FE87E2799017EEA2" modified="2011-05-03" version="1">MEKVKSSDSFTFNESWEEKKERALKIVKKLIEMYPRDRILHGDPFFTLIRCIISQRNRDEVTDRVSELLFNRYPTVHALANAKIEDVQKLLRENGVGLWKNKGKWIVECSRIILEKYGGKVPDMLEELVKLPGIGRKCANIVLAYGFGKQAIPVDTHVNRISKRLGLAPPKAPPEKVEEYLKELIPKELWIYVNHAMVDHGKAICRPISPRCDECPLKTLCPYAKGFISDEEIRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN72</accession>
    <name>F0LN72_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
            <plasmid evidence="2 3">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02238"/>
    <dbReference type="EnsemblBacteria" id="ADT85211">
        <property type="protein sequence ID" value="ADT85211"/>
        <property type="gene ID" value="TERMP_02238"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02238"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2232"/>
    <dbReference type="eggNOG" id="arCOG00093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07614">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059273_0_1_2"/>
    <dbReference type="OMA" id="YWVFAHN"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="300" mass="34564" checksum="154E05F0DCB3A112" modified="2011-05-03" version="1">MRKGKLNPHGWGVGWYLTALHGKRAASLVKQPIPAYKSRIALTLPKLNIKSQVIISHVRFATSEINYLNTHPFIRRIKSIGQYDEWIFAHNGVLDGVEELPRRFKPLGTTDSEAAFCYIMENLEGIRTIRELFTKLYQLLSELSDYGTLNVLISNGRYLFAYSYYPGKGMWLLKRHPPHKGRARLLDEDFEVSIGDVKAEDEYAYLVATKRLTDENWEKIEKKKLYIFRDGALLLKVGNRIEPMLDSEAIEVLRAVLNRENVELNETVKRLVDLKLLKITESGAVINDYREAIVKLIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN92</accession>
    <name>F0LN92_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747453.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02258"/>
    <dbReference type="EnsemblBacteria" id="ADT85231">
        <property type="protein sequence ID" value="ADT85231"/>
        <property type="gene ID" value="TERMP_02258"/>
    </dbReference>
    <dbReference type="GeneID" id="10549082"/>
    <dbReference type="KEGG" id="tba:TERMP_02258"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2252"/>
    <dbReference type="eggNOG" id="arCOG03839">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058982_1_0_2"/>
    <dbReference type="OMA" id="HEDGGIN"/>
    <dbReference type="OrthoDB" id="115092at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="275" mass="32884" checksum="6366327C74C48AE1" modified="2011-05-03" version="1">MVIDEIKRKSFELGLPISTIEKDYVIGWILYGVWRSGLWKDLAFKGGTCLKKAYFSDYRFSEDLDYTLTGKVSEDKLKERLERMLEFANAGPVEFLGLEFELRYGVRNFEGELLGFEVKIPFRLVRRTGTPSKIKMDITLEKYEKIVLPLQEKELLHEYSDADKFSLVRLKSYSLEEIFTEKVRSLFQRTRPRDLYDVWKLKDIIELETAFSILPEKFRLKNVQFELEIFKERRIYYERAWERSLAHQINPLPEFDKVWNDVLKFLEELKESVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F0LNA1</accession>
    <name>F0LNA1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747462.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02267"/>
    <dbReference type="EnsemblBacteria" id="ADT85240">
        <property type="protein sequence ID" value="ADT85240"/>
        <property type="gene ID" value="TERMP_02267"/>
    </dbReference>
    <dbReference type="GeneID" id="10549091"/>
    <dbReference type="KEGG" id="tba:TERMP_02267"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2261"/>
    <dbReference type="HOGENOM" id="CLU_2010207_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="123" mass="15054" checksum="471A8C2D7D60E14D" modified="2011-05-03" version="1">MKINVYKDFEDLEPHHGRKVTKRTLLKVLEKGLYEKIVIDMVLTDDYMWDSVLDFQRGREILNVKKLIEEIKRGWARPYCLALYYPEKHAIEVSWYRHQYYTIYLKPEVRVIEKIKSKRKKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGV5</accession>
    <name>F0LGV5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatinine amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00016"/>
    <dbReference type="EnsemblBacteria" id="ADT82994">
        <property type="protein sequence ID" value="ADT82994"/>
        <property type="gene ID" value="TERMP_00016"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00016"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.15"/>
    <dbReference type="eggNOG" id="arCOG04536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_2_1_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT82994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="364" mass="41545" checksum="57DE10BA74056A2D" modified="2011-05-03" version="1">MSREIPKDLVFEDTPVGRLEKYIWTASEEEIDRILEEFGIPSPPELAKPGVYIQTTPGYRVFEEVRQCDVVLIPIGSTEFHGNHLPSGTDTLYVTQISEAVRRYMKKKGKPVAITWPINYGSHPWHHYGMPGTVIIEEDHLKDYIIDVMLGLWNLGYRKQILINNHGHFWVLESAIQEFMKKYQLPGIYIALDWHRAAGKFFRTKERGGEFETDFVHADEAETSIALLLFPREMVDMDKAVDTTPRAYLPDGHFDKAVDGLLRPMRWSSAEGHIPIEIVNTPEGVVGKATLADAKKAKRAIAFILKYLELLIDQILEKFPPGEVPPVEEVTFRTREEMEDYLKLPGDEGWKPVYGLVKRLGGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGW1</accession>
    <name>F0LGW1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00022"/>
    <dbReference type="EnsemblBacteria" id="ADT83000">
        <property type="protein sequence ID" value="ADT83000"/>
        <property type="gene ID" value="TERMP_00022"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00022"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.21"/>
    <dbReference type="eggNOG" id="arCOG01459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_2"/>
    <dbReference type="OMA" id="ETWYAMS"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="21"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="359" mass="39364" checksum="F69CD66193C5F611" modified="2011-05-03" version="1">MKAAVFKGEGKLVIEDVPKPDLSKDLIIPKKYKPNEFVKVRKEELVLLRVLAAGICGTDLHILSVPPGHTATPGAILGHEFVGEVVDIGSEVDNVNVGDLVAVDPNIKCGKCWFCRNGYPNMCPEMTTLGIYGNGGFAEYAVVPAKQVYVLPRNMDIDKAVLFEPLTTAVHNWEKVNLKPGENILIFGAGPIGAFFIKLAQISGANEIIVSEPSSLRREIARKLGATKVVDPINEDVVEIVHSVTKYGVDVAIDASGVPVVIEQAVRALRPGGRLSLFGQQNIHAFADKVSFTLMNQKELHIFGSYAAAKSFDQTIEILKKRETDDLKNIITHRLKLEDIHKGLELMRKKEALKIVIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGW5</accession>
    <name>F0LGW5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_00026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00026"/>
    <dbReference type="EnsemblBacteria" id="ADT83004">
        <property type="protein sequence ID" value="ADT83004"/>
        <property type="gene ID" value="TERMP_00026"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00026"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.25"/>
    <dbReference type="eggNOG" id="arCOG00767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_2"/>
    <dbReference type="OMA" id="PHNPEPL"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03087">
        <property type="entry name" value="PGM_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="7">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="8">
        <location>
            <begin position="166"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="9">
        <location>
            <begin position="271"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="6">
        <location>
            <begin position="394"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="466" mass="51118" checksum="803D23CF88095C94" modified="2011-05-03" version="1">MSKTKKVMKMGKLFGTFGVRGIANEKITPEFALKIGMAFGTLLKREQPDKELWVVVGRDTRVSGEMLKNALISGLLSVGVNVIDVDIAPTPAIQFACRYFGVDGGAVITASHNPPEYNGIKLLEPNGLGLKKEREAVVEELFFKEEFDMAKWHEIGSLEKRDIIRPYINAIKSKVDVEAIKRRKPFVVVDTSNGAGSLVLPYLLRELGCKVVSVNAHPDGHFPARNPEPNEENLQGFMKIVKSLGADFGVAQDGDADRSVFIDENGNFIQGDKTFALIVKAMLQEHGGGLVVTTIATSHIIDELAKQYGGKVLKTKVGDLIVSRALLEHNGLVGGEENGGVIFPDHVLGRDGAMTVAKIVEIFARSGKKFSELINELPKFYQVKTKRHIEGDRHVIVEKVAKIAEQKGFKIDTTDGTKILFDDGWVLVRASGTEPIIRIFAEARSEEKAKEYLDLGLGLLDEALNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGX0</accession>
    <name>F0LGX0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01202"/>
    <dbReference type="EnsemblBacteria" id="ADT84178">
        <property type="protein sequence ID" value="ADT84178"/>
        <property type="gene ID" value="TERMP_01202"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01202"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1205"/>
    <dbReference type="eggNOG" id="arCOG03422">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3039244_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010863">
        <property type="entry name" value="DUF1495"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07381">
        <property type="entry name" value="DUF1495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="54" mass="6405" checksum="F4B451F8E28EEC45" modified="2011-05-03" version="1">MGLGNRYNGHSSLVSLGLVEIIEENGFKYYRLSEYGKRVVEMLKSYQSYYRKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGX2</accession>
    <name>F0LGX2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Archaeal flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the archaeal flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467478.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01204"/>
    <dbReference type="EnsemblBacteria" id="ADT84180">
        <property type="protein sequence ID" value="ADT84180"/>
        <property type="gene ID" value="TERMP_01204"/>
    </dbReference>
    <dbReference type="GeneID" id="10041521"/>
    <dbReference type="KEGG" id="tba:TERMP_01204"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1207"/>
    <dbReference type="eggNOG" id="arCOG01829">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051124_0_1_2"/>
    <dbReference type="OMA" id="IVEIQDA"/>
    <dbReference type="OrthoDB" id="94462at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097589">
        <property type="term" value="C:archaeal-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35903">
        <property type="entry name" value="PTHR35903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Arch_flagellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0974">Archaeal flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="218" mass="22851" checksum="189D475A6A2EA09D" modified="2011-05-03" version="1">MGYLIKKRRGAVGIGTLIVFIAMVLVAAVAAAVLINTSGYLQQRAEATGRQTTQEVSTGIKIDAVTGYAPSANNMTLMTIQVSLNAGSTPIDLNQTKIYLDNGQKQVVLSYGNAKAAISGDMFDTTSAAWDSTKVDGTHFGILIVQDADNSLNGNIPTLTTGDIALLTVNLTAVFGGVEPRTPITIRVVPEFGAPGFTKVITPTAYGLSTTDKIVDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGY8</accession>
    <name>F0LGY8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467494.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01220"/>
    <dbReference type="EnsemblBacteria" id="ADT84196">
        <property type="protein sequence ID" value="ADT84196"/>
        <property type="gene ID" value="TERMP_01220"/>
    </dbReference>
    <dbReference type="GeneID" id="26136700"/>
    <dbReference type="KEGG" id="tba:TERMP_01220"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1221"/>
    <dbReference type="eggNOG" id="arCOG04026">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_205638_2_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007166">
        <property type="entry name" value="Class3_signal_pept_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04021">
        <property type="entry name" value="Class_IIIsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="61" mass="6845" checksum="23DF2F3E161F3521" modified="2011-05-03" version="1">MRRAQGALEYLFMMAIALMVIIIIYRVHPQSTSGNAEQLGETISNVTSNLTNQVKNEYSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGZ0</accession>
    <name>F0LGZ0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467496.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01222"/>
    <dbReference type="EnsemblBacteria" id="ADT84198">
        <property type="protein sequence ID" value="ADT84198"/>
        <property type="gene ID" value="TERMP_01222"/>
    </dbReference>
    <dbReference type="GeneID" id="10041539"/>
    <dbReference type="KEGG" id="tba:TERMP_01222"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1223"/>
    <dbReference type="eggNOG" id="arCOG00398">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117042_0_0_2"/>
    <dbReference type="OMA" id="ADFPYEG"/>
    <dbReference type="OrthoDB" id="112460at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="190" mass="21820" checksum="0557547747B73A49" modified="2011-05-03" version="1">MKNLKFDGRYKDMLLSGRKRATIRLGKKINLKPGDEVLIHSGGYVLGKGIIKRVETKKVSELTDEDARLDGFKNKEELIKALKEHYKHLTPETPATIIEFEITKLMDKPILSADFPYEGNNPIEIAEKALKYLDNLSFEEIALLNLFLKEGSLRKAAYKLGGLNKRYKIREVLRKAYEELKKKGLMEPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH37</accession>
    <name>F0LH37_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molybdopterin-guanine dinucleotide biosynthesis protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467543.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01269"/>
    <dbReference type="EnsemblBacteria" id="ADT84245">
        <property type="protein sequence ID" value="ADT84245"/>
        <property type="gene ID" value="TERMP_01269"/>
    </dbReference>
    <dbReference type="GeneID" id="10041586"/>
    <dbReference type="KEGG" id="tba:TERMP_01269"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1272"/>
    <dbReference type="eggNOG" id="arCOG00532">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068199_0_0_2"/>
    <dbReference type="OMA" id="HCGYNCK"/>
    <dbReference type="OrthoDB" id="62565at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004435">
        <property type="entry name" value="MobB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03205">
        <property type="entry name" value="MobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00176">
        <property type="entry name" value="mobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S" evidence="5">
        <location>
            <begin position="149"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="242" mass="27044" checksum="A403E70BFE961B8F" modified="2011-05-03" version="1">MKAVAFVGYKKSGKTASLQRVAKVLKERGYKIGIAKSMHADLDKEGSDTWKFRQIADYVLVKAQDTDALLFKADDINAFFSVMPEVDFLLLEGFKSIKHVPKIICARDESDVKELNDGLAIAVSGIIANEKMGNIDGLPIINAFEEPEKLADLIEKKAFMLPNIDCHMCGFTCYEMAKFIVKGEKTLNDCKVISSKPKVVVKIDGKTLPMKDWVQEMVEKTIRGLLSSMKGYRDGKIEIKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH66</accession>
    <name>F0LH66_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83028">
        <property type="protein sequence ID" value="ADT83028"/>
        <property type="gene ID" value="TERMP_00050"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00050"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.51"/>
    <dbReference type="eggNOG" id="arCOG03792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102063_2_0_2"/>
    <dbReference type="OMA" id="RREYQMI"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005489">
        <property type="entry name" value="DUF257"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03192">
        <property type="entry name" value="DUF257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="176" mass="19779" checksum="9576515E72D13C31" modified="2011-05-03" version="1">MRVLVDDFLDTLYIYKVHLELSGTDTSKFEDLQVIKIGGVKSVGKIVGKISSRGGVILRREYQMIYENAIDDGSLVINPVLGIEKLLILGSSRLEVLETLAEISSRLGDKRRIAVYFVDKSVLKTGEFNPLPIMEFLSTTVVNVEKRGRVYTFEVLKSINPELDGKTYSYDLDVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH92</accession>
    <name>F0LH92_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00076</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466352.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00076"/>
    <dbReference type="EnsemblBacteria" id="ADT83054">
        <property type="protein sequence ID" value="ADT83054"/>
        <property type="gene ID" value="TERMP_00076"/>
    </dbReference>
    <dbReference type="GeneID" id="10040395"/>
    <dbReference type="KEGG" id="tba:TERMP_00076"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.76"/>
    <dbReference type="eggNOG" id="arCOG01141">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_4_0_2"/>
    <dbReference type="OMA" id="IHCGDFV"/>
    <dbReference type="OrthoDB" id="78782at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020935">
        <property type="entry name" value="PdiEstase_YfcE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01269">
        <property type="entry name" value="UPF0025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="170" mass="18774" checksum="E5494D153C4B0456" modified="2011-05-03" version="1">MLIGIMSDTHDNLSAIAKAVELFNREGVDLVIHAGDYVAPFVRRELLKLRAPLKGVFGNNDGEKKGLNKALGISEDILEVKADGMKIIVLHGTNEKVVDAFAKSQLYDVIIRGHTHRYEIRETGRSILVNPGEVCGYVTGIKSVAFLDTKKREVKIINLDTEEPLGFMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHB4</accession>
    <name>F0LHB4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl29</name>
        <name evidence="6" type="ordered locus">TERMP_00098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466374.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00098"/>
    <dbReference type="EnsemblBacteria" id="ADT83076">
        <property type="protein sequence ID" value="ADT83076"/>
        <property type="gene ID" value="TERMP_00098"/>
    </dbReference>
    <dbReference type="GeneID" id="26135414"/>
    <dbReference type="KEGG" id="tba:TERMP_00098"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.99"/>
    <dbReference type="eggNOG" id="arCOG00785">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_2_2_2"/>
    <dbReference type="OMA" id="TIMREEE"/>
    <dbReference type="OrthoDB" id="125807at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="66" mass="8006" checksum="303DD1DCF83B236B" modified="2011-05-03" version="1">MKPSEIREMSLEEIEQKIRELRLELAKERGMLTMGTSLENPMVIRNLRRDIARLLTIKREKLRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHC2</accession>
    <name>F0LHC2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps14</name>
        <name evidence="4" type="ordered locus">TERMP_00106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds 16S rRNA, required for the assembly of 30S particles.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466382.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00106"/>
    <dbReference type="EnsemblBacteria" id="ADT83084">
        <property type="protein sequence ID" value="ADT83084"/>
        <property type="gene ID" value="TERMP_00106"/>
    </dbReference>
    <dbReference type="GeneID" id="10040425"/>
    <dbReference type="KEGG" id="tba:TERMP_00106"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.107"/>
    <dbReference type="eggNOG" id="arCOG00782">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177289_2_2_2"/>
    <dbReference type="OMA" id="HCFREIA"/>
    <dbReference type="OrthoDB" id="122051at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_A">
        <property type="entry name" value="Ribosomal_S14_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="40S_S29/30S_S14z"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023676">
        <property type="entry name" value="Ribosomal_S14_type-Z_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="PTHR12010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="56" mass="6714" checksum="A644D5FF177D1B86" modified="2011-05-03" version="1">MAKADYNRRKPRRFGKGARRCIRCGQYGPIIRIHGLMLCRHCFREMAPKLGFRKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHF1</accession>
    <name>F0LHF1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">rRNA biogenesis Nop5/Nop56-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467576.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01303"/>
    <dbReference type="EnsemblBacteria" id="ADT84278">
        <property type="protein sequence ID" value="ADT84278"/>
        <property type="gene ID" value="TERMP_01303"/>
    </dbReference>
    <dbReference type="GeneID" id="10041619"/>
    <dbReference type="KEGG" id="tba:TERMP_01303"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1304"/>
    <dbReference type="eggNOG" id="arCOG01923">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_1_0_2"/>
    <dbReference type="OMA" id="REWYSLH"/>
    <dbReference type="OrthoDB" id="89321at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D RNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="PTHR10894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="SSF89124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nop" evidence="3">
        <location>
            <begin position="252"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="413" mass="47738" checksum="F7AF5A181DCA6486" modified="2011-05-03" version="1">MKAYISENVQGIYAFDESGNLIAKREYREKPEIALDRLLSGEITDDLIAFLEELKEKGYEEFIFEHPDLSRKAKELGFNADAEFPNLAGEILRKRPEEFLGKEWFERYYSVGVALTRLRIQEQSGARDKMVIQAIEALDDIDKVINLLVSRLREWYSLHFPELDEILPKHPQYVAFVKNIGHRENVTKENLEKLGFSEGKIERILKAKEKTMGAWMDEKDIKIIQDFAKEIDDLYKLREEIEDYIDRAMDDVAPNLKGLVGAKLAARLISLAGGLKELAMMPSSTIQVLGAEKALFRHLRTGAKPPKHGVIYQYPAINKSPWWQRGKIARALAGKLAIAARVDYFSGEYIAEELKKELEARIKEIKEKYPNPPKRKEKPKKKKKEKFKKGKKFKGKEKGKKFKGKKEKGKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHG9</accession>
    <name>F0LHG9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthine synthase</fullName>
            <ecNumber evidence="6">2.1.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dphB</name>
        <name evidence="9" type="ordered locus">TERMP_01321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36415"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="2.1.1.98"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.98" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467594.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01321"/>
    <dbReference type="EnsemblBacteria" id="ADT84296">
        <property type="protein sequence ID" value="ADT84296"/>
        <property type="gene ID" value="TERMP_01321"/>
    </dbReference>
    <dbReference type="GeneID" id="10042561"/>
    <dbReference type="KEGG" id="tba:TERMP_01321"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1322"/>
    <dbReference type="eggNOG" id="arCOG04161">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066040_0_0_2"/>
    <dbReference type="OMA" id="TAGDPMV"/>
    <dbReference type="OrthoDB" id="102360at2157"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004164">
        <property type="term" value="F:diphthine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="PTHR10882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6 7">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="266" mass="30248" checksum="0F044159B67D496F" modified="2011-05-03" version="1">MAIYFIGLGLYDEKDITLKGLEIARKCDLIFAEFYTSLLAGAKIEKIEKLIGKPIRVLNREEVELHFERIVLSEAKNRDVAFLTAGDPMVATTHADLRIRAKQMGIESYVIHAPSIYSAVSITGLQIYKFGKSATVAYPEKNWFPTSHYEVIKENKERGLHTLLFLDIKADQGRYMTANEAMDILLQVEEMKRQNVFTPETFVVVLARAGSLNPTLKAGYVEDMIKEDFGKQPHIMVVPGRLHIVEKEYLVAFADAPEEILRRRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHI9</accession>
    <name>F0LHI9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TrmB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467614.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84316">
        <property type="protein sequence ID" value="ADT84316"/>
        <property type="gene ID" value="TERMP_01341"/>
    </dbReference>
    <dbReference type="GeneID" id="26136825"/>
    <dbReference type="KEGG" id="tba:TERMP_01341"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1341"/>
    <dbReference type="eggNOG" id="arCOG02243">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173773_0_0_2"/>
    <dbReference type="OMA" id="NRGWLGY"/>
    <dbReference type="OrthoDB" id="107069at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="107" mass="12558" checksum="EE91CF7D5F009657" modified="2011-05-03" version="1">MEEMLKAFTNTLEKFKLTRSEIRIYSLLLKEQLTPRQIAKKLGLSERIVREKLQHLLELGLVERELISRGWIGYLYKAKAPNEALDSLLSKMEELIKSLKKEANRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHJ4</accession>
    <name>F0LHJ4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Na_H_Exchanger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01346"/>
    <dbReference type="EnsemblBacteria" id="ADT84321">
        <property type="protein sequence ID" value="ADT84321"/>
        <property type="gene ID" value="TERMP_01346"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01346"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1346"/>
    <dbReference type="eggNOG" id="arCOG01953">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_2"/>
    <dbReference type="OMA" id="APIFFAW"/>
    <dbReference type="OrthoDB" id="79669at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="9"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="378" mass="42178" checksum="D81569C53DE11934" modified="2011-05-03" version="1">MDVIGYVFIIIAVARILAEIFERLGYPGFLGEISAGLLLGVLLKNLPREEMALLAELGIFFLMIYAGLELTPEEIHLGGRKSLPMYVATYVVMLFLTLPFTNYRFSTDNLIVASILAVASAPIVIRFTRFFGHDFLHVALSYAVISEVGSLVILYLLINFELHHLSYMELFFEFVKDIVFLGTVLGLNYFIGIQHKVWIIRALRRLKSDEAVFGIVMILATSLALISEQIGLHFSIGAFLVGLILHSDLVGTKQYERLYTIISGVTYGIFAPIFFAWRGINFETEFSLEVVYFFVVIYLVRVLLTTVLVWEHDLKTSLARGAGIASFGVLGLLVGEIGYTYGVLSQHMYALASLASIMGIFVSATIGRIISHINNNEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHK9</accession>
    <name>F0LHK9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Protein translocase subunit SecY</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein transport protein SEC61 subunit alpha homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">secY</name>
        <name evidence="15" type="ordered locus">TERMP_00115</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466391.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00115"/>
    <dbReference type="EnsemblBacteria" id="ADT83093">
        <property type="protein sequence ID" value="ADT83093"/>
        <property type="gene ID" value="TERMP_00115"/>
    </dbReference>
    <dbReference type="GeneID" id="10040434"/>
    <dbReference type="KEGG" id="tba:TERMP_00115"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.116"/>
    <dbReference type="eggNOG" id="arCOG04169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031763_3_0_2"/>
    <dbReference type="OMA" id="KWGIGSG"/>
    <dbReference type="OrthoDB" id="13531at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Plug_translocon" evidence="14">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADT83093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="462" mass="51795" checksum="7CA28C2531B64AED" modified="2011-05-03" version="1">MGVRDVVYALERWFPEIERPKRHVPLKEKFAWTGIVLLLYFILSEIPLFGMPPTVQDYFQTLRVVLAGRSGSILTLGIGPIVTAGIIMQLLVGSEIIKLDLSDHEDRRFYQALQRVFAVFMCFFEAAIYVFAGAFGNPATSIKILLMLQLAMGGILLIIMDELVSKWGIGSGISLFIAAGVSQTIITRAFNPLTTTQVIDPLTGKPAIIGAIPAFIQHLINGDLTGGFYRGNLPDMSNVLATFVVFLIVVYLESMRVEIPLSYGRVTVRGRYPIRFMYVSNIPIILTFALYANIQLWARLLQRLGHPILGQFDPETGAAISGFVRYTIPPRDIFHVTADPVRALIYAIMTIFFSLMFGFLWVELTGLDAKSIARQLQRAGLQIPGFRRDPRILERVLQRYIPYVTFWGSFTLAVVAILADFLGALGTGTGILLTVGILYRFYEEIAREQVSEMFPMLRRFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHL6</accession>
    <name>F0LHL6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HicB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466398.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00122"/>
    <dbReference type="EnsemblBacteria" id="ADT83100">
        <property type="protein sequence ID" value="ADT83100"/>
        <property type="gene ID" value="TERMP_00122"/>
    </dbReference>
    <dbReference type="GeneID" id="26135438"/>
    <dbReference type="KEGG" id="tba:TERMP_00122"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.123"/>
    <dbReference type="eggNOG" id="arCOG02411">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114047_10_2_2"/>
    <dbReference type="OMA" id="YIAECPE"/>
    <dbReference type="OrthoDB" id="119160at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031807">
        <property type="entry name" value="HicB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15919">
        <property type="entry name" value="HicB_lk_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HicB-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="74" mass="8436" checksum="A227BFBF76F9761E" modified="2011-05-03" version="1">MLTLHAVIWEEEGVYVVKEVFTGVTTQGETIEEALENLKEAVELYLEEFPELKEELRKIKLIGDFNVQIAKALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHM6</accession>
    <name>F0LHM6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl13</name>
        <name evidence="5" type="ordered locus">TERMP_00133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466408.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00133"/>
    <dbReference type="EnsemblBacteria" id="ADT83110">
        <property type="protein sequence ID" value="ADT83110"/>
        <property type="gene ID" value="TERMP_00133"/>
    </dbReference>
    <dbReference type="GeneID" id="10040451"/>
    <dbReference type="KEGG" id="tba:TERMP_00133"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.134"/>
    <dbReference type="eggNOG" id="arCOG04242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076922_1_0_2"/>
    <dbReference type="OMA" id="GMLPWKT"/>
    <dbReference type="OrthoDB" id="87367at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_L13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="PTHR11545:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="142" mass="16429" checksum="8142E387E2AEEB9B" modified="2011-05-03" version="1">MRIINAEGLILGRLASKVAKMLLEGEEVIIVNAEKAIITGNREDIFAKYKQRTELRTRTNPRRGPFYPKRSDEIVRRTIRGMLPWKTDRGRKAFKRLKVYAGVPKEFEGREFETIMEAHMSRLKTPKYVTVGEVAKYLGGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHQ2</accession>
    <name>F0LHQ2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P protein component 2</fullName>
            <shortName evidence="5">RNase P component 2</shortName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pop5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnp2</name>
        <name evidence="6" type="ordered locus">TERMP_00159</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466434.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00159"/>
    <dbReference type="EnsemblBacteria" id="ADT83136">
        <property type="protein sequence ID" value="ADT83136"/>
        <property type="gene ID" value="TERMP_00159"/>
    </dbReference>
    <dbReference type="GeneID" id="10040477"/>
    <dbReference type="KEGG" id="tba:TERMP_00159"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.160"/>
    <dbReference type="eggNOG" id="arCOG01365">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137733_1_0_2"/>
    <dbReference type="OMA" id="NPWLIDY"/>
    <dbReference type="OrthoDB" id="89278at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00755">
        <property type="entry name" value="RNase_P_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016434">
        <property type="entry name" value="Rnp2_archaea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004952">
        <property type="entry name" value="RNase_P_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="SSF160350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="119" mass="13924" checksum="E79F09F7D9DF78BD" modified="2011-05-03" version="1">MKERPKTLPPTLRDKHRYIAFQVIGERNFKKDEIKKAIWDAALRVLGELGTSRAKPWFIKFNERTQTGILRCDRKHVEEVRFALAMLTEINGSKAIIRTLGVSGTIKRLRLKFLKEFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHX3</accession>
    <name>F0LHX3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF302 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01398"/>
    <dbReference type="EnsemblBacteria" id="ADT84373">
        <property type="protein sequence ID" value="ADT84373"/>
        <property type="gene ID" value="TERMP_01398"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01398"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1398"/>
    <dbReference type="eggNOG" id="arCOG02761">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126998_1_1_2"/>
    <dbReference type="OMA" id="LPCKIVV"/>
    <dbReference type="OrthoDB" id="98045at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="SSF103247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="2">
        <location>
            <begin position="99"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="186" mass="20175" checksum="2848D4CFAF897B18" modified="2011-05-03" version="1">MKGEMNEMENGGVGGHGKMGGMKGMKGKGKMKGGCKGHGKGMKGMGKGRHGMHGMEEPKKGYAYVREVETGFDETVARVKEELKKEGFGVLSEVRVDRLFKEKLDLDMEPYVILGACNPKFSSQLIGIDINSGTFLPCNLVVYVKDGKTYVSLLLPTKAMSITGNDELLEVAAKVEEILKGVVDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHX8</accession>
    <name>F0LHX8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CitMHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01403"/>
    <dbReference type="EnsemblBacteria" id="ADT84378">
        <property type="protein sequence ID" value="ADT84378"/>
        <property type="gene ID" value="TERMP_01403"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01403"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1403"/>
    <dbReference type="eggNOG" id="arCOG00238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063025_1_0_2"/>
    <dbReference type="OMA" id="ICSMFVT"/>
    <dbReference type="OrthoDB" id="49249at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="7">
        <location>
            <begin position="6"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="348" mass="38197" checksum="9E1BE0FF6F6D9AC2" modified="2011-05-03" version="1">MLLLYVLLSIVDISLLGRTLKLIDYESLSAIVSLLMVSRGLELSGVFTRIAPYIIRLSDGDEKRFLFIMIVIVSFSSSLIMNDTAMFVFIPLIMTMSKIAEIDVKKAVSLTAIAANVGSALTPIGNPQNIIIWRFYRVSVHEFILAMFPYVFLWVFVLLLFVFIGGGKEQFQVFTMPDVKLNKTLMFSSATLLFVDVVLIQLGHALWALPLTLAILTVVERRILLSIDIALIITFAFIFIDFKELSMLMHAFNILPTLKSSIGVVLLSAGLSQLISNVPATVVLISAGKPEWLPLALGVNLGGTGIVIGSLANLIALRISGIGIRDFHKYSIPYFLIALGSSILVVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI07</accession>
    <name>F0LI07_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VanZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467705.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01432"/>
    <dbReference type="EnsemblBacteria" id="ADT84407">
        <property type="protein sequence ID" value="ADT84407"/>
        <property type="gene ID" value="TERMP_01432"/>
    </dbReference>
    <dbReference type="GeneID" id="10041748"/>
    <dbReference type="KEGG" id="tba:TERMP_01432"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1432"/>
    <dbReference type="eggNOG" id="arCOG10114">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2313935_0_0_2"/>
    <dbReference type="OMA" id="YLLWRWW"/>
    <dbReference type="OrthoDB" id="116305at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="108" mass="12236" checksum="23A4D3943D4AC58F" modified="2011-05-03" version="1">MRGKILFAYLIFLFYVNLMPRVPTVPISGGDKIAHFLEFLILGILGYNKAFLLVLPIVLEYLQLFVPGRCFSYYDMIANLIGFGVGVTVGWWYESGKKGALPFHKGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI11</accession>
    <name>F0LI11_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine 2,3-aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83165">
        <property type="protein sequence ID" value="ADT83165"/>
        <property type="gene ID" value="TERMP_00188"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00188"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.189"/>
    <dbReference type="eggNOG" id="arCOG03246">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_440512_0_0_2"/>
    <dbReference type="OMA" id="CQRMYDF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00238">
        <property type="entry name" value="TIGR00238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="647" mass="76369" checksum="EAE01BB72631377D" modified="2011-05-03" version="1">MPKYGHGVIGMEKQMESAVSTFNIEESPWGLKQGINHEDFLKIFDPLPEIKEILLTSENVEEARDKLRRFAEDLLWKYKNGDIDVDAMDRWLAIEAINVFLNIISEYGEKAAGFSTLEYLWKATKGDKRVLSIITEGFVEEFKHLFKAMAGVTGYSKGWLGPKLEAAGVKFVDFSKIKGRKAALMRSEYLDKVWEYIKSYLKKYPSGLDKHIIEKRKRQREKLMEYWGITEDEWFDYRWQFSHVLKREKGLETLRELNELGIVKVPEEDLKQVEIAVKYGIPWGITPYYLHLWDFENPYKEDRHVRRQVMPPTWYVSNMLQHREDREYYFDFMGEHDTSPLDLITRRYVTIAILKAYDTCPQICVYCQRNWEVLEPFMAGSFPGWDKIEAAIEWFGEHESMLDVLITGGDPLALSDKIIDKIMSRLSEFDHVVNIRWGSRIFVTVPMRITNSLAEILGSYIEPGKRNVSISTHFETAYEVTPEVAEATYKIRRQGIYIYNQLVYQRNVSRRFENVALRIALRKVGIDPYYTFYPKGKIEQKDYLVPIARVVQERKEEARLLPGQFRPDEPVFNVPRMGKNHLRAWQDRELVGIRPDGSRIYLMHPWEKGISETKLYTYPDVPIKEYLEYLESIGEDPNDYWTIWYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI42</accession>
    <name>F0LI42_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466494.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00219"/>
    <dbReference type="EnsemblBacteria" id="ADT83196">
        <property type="protein sequence ID" value="ADT83196"/>
        <property type="gene ID" value="TERMP_00219"/>
    </dbReference>
    <dbReference type="GeneID" id="26135548"/>
    <dbReference type="KEGG" id="tba:TERMP_00219"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.219"/>
    <dbReference type="eggNOG" id="arCOG00136">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050484_0_0_2"/>
    <dbReference type="OMA" id="RYYGFFE"/>
    <dbReference type="OrthoDB" id="22281at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="244"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="434" mass="47510" checksum="2003D780D63100D6" modified="2011-05-03" version="1">MERKKFSWGIVLGLALLGFSRSVGWALNKGLSFPLLSSYTQSAFVKGTILALEGIIGLLIPPLLGYYSDTLKSKHGRRRPFIMIGGFLAGIAALMIYTAYALGIPLAGFALTLAFFYFSMHLYTAQFRALMPDTIESGERGKASGVITLLEWAGNLFLFGLAGFLIAKAVAETGEAEGIKALAQTPYLKIPFIITAVFLIGAALFVYFIVKEPKAPEIEEDESLIGYLKSIVENRDFLKFYAAQTLWWMSFEFIAIFLYGILAFILHGAATEENVKAVTSLGLYLMALFNITVLLGALPGGIIYDKLGRRLSIILGGIIFALPQLWGWFISTQTEIVIALGLAGIGWGILMAASYPVIGDLLTHYEREAFTGRYYGFFEATRSLPVLLAGTIGGAIVDLAGENYRILFPIGALLVLLAMPMIWRMKNLEPGEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI76</accession>
    <name>F0LI76_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466528.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00253"/>
    <dbReference type="EnsemblBacteria" id="ADT83230">
        <property type="protein sequence ID" value="ADT83230"/>
        <property type="gene ID" value="TERMP_00253"/>
    </dbReference>
    <dbReference type="GeneID" id="10040571"/>
    <dbReference type="KEGG" id="tba:TERMP_00253"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.253"/>
    <dbReference type="eggNOG" id="arCOG05844">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051622_0_0_2"/>
    <dbReference type="OMA" id="KWGSWLL"/>
    <dbReference type="OrthoDB" id="67565at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="432" mass="49420" checksum="34F7784016A22191" modified="2011-05-03" version="1">MTKVDVAGEVLKLTSMIRDPYFRAISYARIGYQLFLLRDNRYKKAFTKAVETVKMIEDPIVMIKTLIEIGKYLRKAKIAAAVKVFHQAFEMTKAIPNPVHDELIESIVNTLIELKMHDEALMYTSEIKDKIRKNEMLLRLLISYINTGKVRKAYSILEIIDEEPWYSIAAVELLKTHLKREEFGSAMKILQSLRSKYWINEAMKEIAIHLKNYGAPRATFEKFVDAALTMADELSFDALRNLLVGFGSSGEIDSVIKIIKKMPPAERIKTLKEISAKIIEDEELLRILMIKIGREEFIPVAKFLLTKLLEKPDKKYIKVVETIGARTGNEAILVKVVTFLAKVGEYNKALHFAHRVTDSHLRSLAFGSIAVNLLKEGDIDRAIDTALEVKDPKWGSWLLGELLVKILELAKSKEVEDDLEKRANEQKTLWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIA1</accession>
    <name>F0LIA1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01456"/>
    <dbReference type="EnsemblBacteria" id="ADT84431">
        <property type="protein sequence ID" value="ADT84431"/>
        <property type="gene ID" value="TERMP_01456"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01456"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1456"/>
    <dbReference type="eggNOG" id="arCOG03792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102063_1_0_2"/>
    <dbReference type="OMA" id="NPVLGIH"/>
    <dbReference type="OrthoDB" id="88087at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005489">
        <property type="entry name" value="DUF257"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03192">
        <property type="entry name" value="DUF257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="223" mass="25725" checksum="893DF308F941AE32" modified="2011-05-03" version="1">MAEHGFEFIFSKMRAGETVLIEYASVSSPEILLYVMERYCRQNDIPMIIDDIADTLPEFLTRLELIGLLIKGFGSIPVIKIGGHRESGEIVGRIDIEKYSLDFQYYNPVYEKVRPSKMAYNPVLGIHKLLLINSIKEYGGGVRLLRNISRYVGNKTRIAFYFINKSLVQSKFPEFLYLFEEIATSVMQWERSGSTYKLKVIKSANDDILEKIATIEFEDIKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LID1</accession>
    <name>F0LID1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane bound hydrogenase MbhM-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01486</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467759.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01486"/>
    <dbReference type="EnsemblBacteria" id="ADT84461">
        <property type="protein sequence ID" value="ADT84461"/>
        <property type="gene ID" value="TERMP_01486"/>
    </dbReference>
    <dbReference type="GeneID" id="10041802"/>
    <dbReference type="KEGG" id="tba:TERMP_01486"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1486"/>
    <dbReference type="eggNOG" id="arCOG01545">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_2_2"/>
    <dbReference type="OMA" id="MYVGMGI"/>
    <dbReference type="OrthoDB" id="88886at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="329" mass="36456" checksum="16B6F498A18027DB" modified="2011-05-03" version="1">MNLLYATLGLIALYIYVSFASLLWEGIDRKLVARMQRRVGPPLLQPFYDFLKLMSKESIIPKHANKFYELAPVLALAVSIALLAYTPMGFAPLFATKGDVIVFIYLLTLIGFIRVLGAISSGSPYAQIGAQREMIILVSREVPMMLALFTILWRLNNIGVEKPFSLATFYQRNIWELGTPLALIGTFILLVVFLAWLASEIEVGFFDIPEAETEVAEGPMAEYSGRHLALFELSNAIKMFVSASLVVAIFFPWGISAYVGLNGIPALVVDVLFHTIKVFAVLFVSMSIFRAITGRLRITQAVQVFWLRLFPAAIIGSLILAIDLLGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIF6</accession>
    <name>F0LIF6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-dependent DNA helicase Hel308</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hel308</name>
        <name evidence="6" type="ordered locus">TERMP_01511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. Hel308 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01511"/>
    <dbReference type="EnsemblBacteria" id="ADT84486">
        <property type="protein sequence ID" value="ADT84486"/>
        <property type="gene ID" value="TERMP_01511"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01511"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1511"/>
    <dbReference type="eggNOG" id="arCOG00553">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006553_3_0_2"/>
    <dbReference type="OMA" id="MFLNANI"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00442">
        <property type="entry name" value="Helicase_Hel308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022965">
        <property type="entry name" value="Helicase_Hel308"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="54"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="247"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="730"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="755" mass="86030" checksum="741C4378DAC87115" modified="2011-05-03" version="1">MLSTKPKAYKRFSPIGYAMQVDELSKFGVDERIIRKIKERGISEFYPPQAEALRSGVLNGENLLLAIPTASGKTLVAEIVMLHKLFTGGGKAVYLVPLKALAEEKYREFKTWEDLGVRVAVTTGDYDSSEEWLGKYDIIIATSEKFDSLLRHKSRWIRDVTLIVADEIHLLGSYDRGATLEMILSHMLGKAQILGLSATVGNAEELAEWLNAKLVVSDWRPVKLRKGVFAHGQLIWEDGKVDKFPPQWDSLVIDAVKKGKQALVFVNTRRSAEKEAGMLGKKVRRLLTKPEARRLKELAESLESNPTNDKLKEVLVNGAAFHHAGLGRAERTLIEDAFREGLIKVLTATPTLAMGVNLPSFRVIIRDTKRYSTFGWSDIPVLEIQQMIGRAGRPKYDKEGEAIIVAKTEKPEELMEKYIFGKPEKLFSMLSNDAAFRSQVLALITNFGVESFRELIGFLEKTFYYHQRKDLEILEGKAKSIVYFLLENEFIDIDLNDSFIALPFGIRTSQLYLDPLTAKKFKDALPQIEENPNPLGIFQLLASTPDMGTLSIKRKEQESYLDYAYEMEDYLYRSIPYWEDYEFQKFLSEVKTAKLLLDWINEVSEAKLIEAYGIDTGDLYRIIELADWLMYSLIELAKVLNAGGETIKYLRRLHLRLKHGVREELLELVELPMIGRRRARALYNAGFKNVNDIVKAKPSELLAVEGIGVKVLERIYRHFGVELPLLKNIKDPDKPEDKPKEKPKPKKGTLDYFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LII5</accession>
    <name>F0LII5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-(G10-N2) methyltransferase, tRNA-(G10-N2) dimethyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466557.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00282"/>
    <dbReference type="EnsemblBacteria" id="ADT83259">
        <property type="protein sequence ID" value="ADT83259"/>
        <property type="gene ID" value="TERMP_00282"/>
    </dbReference>
    <dbReference type="GeneID" id="10040600"/>
    <dbReference type="KEGG" id="tba:TERMP_00282"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.282"/>
    <dbReference type="eggNOG" id="arCOG00047">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057819_1_0_2"/>
    <dbReference type="OMA" id="FFHPGVM"/>
    <dbReference type="OrthoDB" id="47556at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004809">
        <property type="term" value="F:tRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005885">
        <property type="entry name" value="TrmG10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01177">
        <property type="entry name" value="TIGR01177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="44"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="333" mass="38162" checksum="3EADD480BAF53576" modified="2011-05-03" version="1">MLYVEILGNLPSLAKSEVKALIELADRRFKIAEEDYLLLAIRGNERAFPFLDRLGMAHEYGILLFSAENVEELYAKAESIDWSEYIAGTFKVDRETMRNCAHDVENLEKKLGAIIYRQGFRVNLSNPNTLVRVYCGKKLWVGIRVRFFKAKTFDERKADKRPFYKPIALPPRIARAMVNLARAKMEILDPFMGTGGILIEAGLMGLKVYGVDLRRDMVEGARINLEYFGVKCYVLKRGDATKLREIFPDKTFEAVATDPPYGSSATLAGRKREELYEKALESIYEVLDGYLSIAFPADFNAEKIAEKIGFEVLEKHYQRVHSSLDRYFYVMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIJ2</accession>
    <name>F0LIJ2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466564.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00289"/>
    <dbReference type="EnsemblBacteria" id="ADT83266">
        <property type="protein sequence ID" value="ADT83266"/>
        <property type="gene ID" value="TERMP_00289"/>
    </dbReference>
    <dbReference type="GeneID" id="10040607"/>
    <dbReference type="KEGG" id="tba:TERMP_00289"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.289"/>
    <dbReference type="eggNOG" id="arCOG04044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057069_2_2_2"/>
    <dbReference type="OMA" id="FVKVNYP"/>
    <dbReference type="OrthoDB" id="36379at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="281" mass="31151" checksum="4CCE17D0C88CB08C" modified="2011-05-03" version="1">MEAFQNIGIRRRLRRFFRRDGRALIFAMDHGFEHGPEDFTEVWEHVNPRVILKKVIRAGVDGVMLLPGIARVSGDVLNPNVGLMVKLTSKTNLRPKEDQFLQSPLGFVEDAIKLGADAVAATVYWGSPYEDIMMKQFAEVASIAHDFGLPVVQFSYPRGPYINEKYGKKEDYRVVMYGARAAAEMGADMIKTYWTGSKETFAKVVDAAAGVPVLLSGGAKAKNPLEFLKVVYEVIEAGGAGAVVGRNIFQRENPEPMIKAILRVIHRNEEPEEAAKAEGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIL1</accession>
    <name>F0LIL1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">YpdF-like aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00308</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00308"/>
    <dbReference type="MEROPS" id="M24.008"/>
    <dbReference type="EnsemblBacteria" id="ADT83285">
        <property type="protein sequence ID" value="ADT83285"/>
        <property type="gene ID" value="TERMP_00308"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00308"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.308"/>
    <dbReference type="eggNOG" id="arCOG01000">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_2_2"/>
    <dbReference type="OMA" id="YCSDRTR"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="5">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="149"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="365" mass="41036" checksum="5BDF97B7479F266F" modified="2011-05-03" version="1">MERVLFSLSYSALVVIMKMERIKKLQKFINENSIDAALISKRENLFYFSGASPLAGGYLVVTPDEAIIYVPELEYEATKEETELPVEKFKRLPELYEKLKPYSILGIEGSTSFSFMNALKEKAEIKEFRNVDDVIKDLRIVKTKEEIEIIKSACELADMAVMAAIEEISEGKREREIAAKVEYVMKMNGAEKPAFDTIIASGHRAALPHGVASDKRIERGDLVVIDLGALYRHYNSDITRTIVVGKPNEKQKEIYEVVLEAQKTAVEKAKPGMTAKELDSIARNIIAEYGYGDYFIHSLGHGVGLEIHEPPRISQYDESVLKEGMVVTIEPGIYIPKLGGVRIEDTVVITKDGAERLTKMERELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIN3</accession>
    <name>F0LIN3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC_transp_aux domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466605.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00330"/>
    <dbReference type="EnsemblBacteria" id="ADT83307">
        <property type="protein sequence ID" value="ADT83307"/>
        <property type="gene ID" value="TERMP_00330"/>
    </dbReference>
    <dbReference type="GeneID" id="10040648"/>
    <dbReference type="KEGG" id="tba:TERMP_00330"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.330"/>
    <dbReference type="eggNOG" id="arCOG01312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03256">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03400">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020782_0_0_2"/>
    <dbReference type="OMA" id="AYQSMRV"/>
    <dbReference type="OrthoDB" id="20898at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019196">
        <property type="entry name" value="ABC_transp_unknown"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09822">
        <property type="entry name" value="ABC_transp_aux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC_transp_aux" evidence="2">
        <location>
            <begin position="308"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="687" mass="77158" checksum="137C3C74DD29D5D1" modified="2011-05-03" version="1">MKRWSLFLIIVMIFSIVPVSTIGFVNAATYVPIPEIQGYSSSSPYTGQTVITTGVVTAVASKGFFMQNGTGPWTGIYVYTGSAPSVQVGDLVEVRGYVKEYYGLTEISVNPKYGDYVKVLGTAPVPEPVTLPSGNVSQEKWESVLVKVVGVTVVDPDLGYGEWLVDDGSGPVRIDDLIYRYTPEYGQKFDYIIGPVYYSYGNFKIEPRGPEDLKEYIPEIKIAELNVDRSLVKGVPAPISVLIKNDGIFSENVTLLIYANDEILLNTSLILDPGMNYSTTTTWTPSSTGDAVIRAEIVGYDEKYVPVTVYENPQTVAFTIVTYYHYRYEKYWTILSPLYEQFDALMTELQKYNVDLGPLQDEIEKIESNMQQINEEYSKYESLKIYTRNGYYLPLMPHIRKAALLSRETISMINDVLPLLNSTLEQIKAMIQQQQNATGGNETTVQNVTVTVPKLVKVLIDSGHNQYYNDEKMSSLINKIEEELGWKVEINRGTLTSEKLQGYNILIITNPRTDITDEEAQAIKEFVKNGGGLLILGDWYKYVNTKSLNKVVEEFGIRFNKDELMDNDRNTGRPYFPLVGEFNFEHPATKFLNETSELYYNGDTLDVSGDVVWLIRGYDSSYAVDQTGKVTKEKGSKPIVAAAVEVGEGRIVAYGSSKAISDDYYGRYITTNWPFIKGVLLWLAGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIN8</accession>
    <name>F0LIN8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466610.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00335"/>
    <dbReference type="EnsemblBacteria" id="ADT83312">
        <property type="protein sequence ID" value="ADT83312"/>
        <property type="gene ID" value="TERMP_00335"/>
    </dbReference>
    <dbReference type="GeneID" id="10040653"/>
    <dbReference type="KEGG" id="tba:TERMP_00335"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.335"/>
    <dbReference type="eggNOG" id="arCOG05759">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151178_1_0_2"/>
    <dbReference type="OMA" id="PEYCRDW"/>
    <dbReference type="OrthoDB" id="119434at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016621">
        <property type="entry name" value="UCP014543"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12646">
        <property type="entry name" value="DUF3783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014543">
        <property type="entry name" value="UCP014543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="131" mass="15617" checksum="EACABCB599FF8536" modified="2011-05-03" version="1">MIFLIGFDKNEVKKIREMLSELKVYEIPQYCRDWSVQSIVEKAEELEGSCDWHLKKFILMHDLKNPQIREVLARIKSLNLGKIIFATTTPTSLTWKLEDLLEELIREDEYFQELKRKEAQQKRLYLDIGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIR9</accession>
    <name>F0LIR9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type multidrug transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01546</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467819.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01546"/>
    <dbReference type="EnsemblBacteria" id="ADT84521">
        <property type="protein sequence ID" value="ADT84521"/>
        <property type="gene ID" value="TERMP_01546"/>
    </dbReference>
    <dbReference type="GeneID" id="10041862"/>
    <dbReference type="KEGG" id="tba:TERMP_01546"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1546"/>
    <dbReference type="eggNOG" id="arCOG01465">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089201_0_0_2"/>
    <dbReference type="OMA" id="MRRITFF"/>
    <dbReference type="OrthoDB" id="60393at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="17"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="273" mass="30452" checksum="97773162F7917593" modified="2011-05-03" version="1">MAVTEELRALYGVAVKSWRIFLSYKLWMISDIMLGFFFVGQALLIGIGLTGQRNSPALQRMTGYSDYLTFAVLGFMVLGFGLTFMSGFVWSVVDELYAGTLEYSFAAPMRRITFFLGNVLVRIFLSFIYMAVYIPLFVIVFDVHINSAGFFKGIPVLLLGTVGMIGLGMTAAGIVLYLRDPGPFINILEMLVFALSGAMYPIKILPKPLQLLAKAMPYAPTSEAVRKVVAFGYSNSINEIGYLLFISTIYALFGYFVYKWSEKQARIVGLKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIV1</accession>
    <name>F0LIV1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467851.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01578"/>
    <dbReference type="EnsemblBacteria" id="ADT84553">
        <property type="protein sequence ID" value="ADT84553"/>
        <property type="gene ID" value="TERMP_01578"/>
    </dbReference>
    <dbReference type="GeneID" id="10041894"/>
    <dbReference type="KEGG" id="tba:TERMP_01578"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1578"/>
    <dbReference type="eggNOG" id="arCOG06468">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_504930_0_0_2"/>
    <dbReference type="OMA" id="HIMFPRD"/>
    <dbReference type="OrthoDB" id="17530at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="539" mass="57828" checksum="80511BB94470E3A1" modified="2011-05-03" version="1">MNTKIIGSGVLAALLVLSIVGYVGAFGGGGEGKLEYKVYSKEQIMSGAYKVYGNPKLGFWVAKVVLHNSGNGAIKNIKISYSIDNYAPEVERSYPILVPNGTIVDLYFPILSSEVTKLTASTPSNLRIRITYEVNGETKEESITKSLSILGVNDFVFSSLSPEESTGSFYDTFSNAPLLAAWVTPSDPVVREFADMGNKLAGGAGASLSDDEAIKSLSGMWALAVINGFSYKTEGEGYWTGKFAEHIMFPRDVIRDKSGTCIDLALWFSSLAMSQGLKAYIVLMPGHAFPLIQLPSGAIIPVEATAINSGVSFQEAIQAGINTWQKAMSGPYIVVNIAEEHSKGIVPPELPQLPADILSKWGITLQPTGGTQEGTTGGMTGGTGGGGTGETGGETGGNNGNQRWNTYLGQYFSFDYPADWDNPEDYGGYVYLLSPDGEFEFMVIYSQGASVQDMVYAFENSLAEAGATIKDRQETQASIAGQTVYTVLYTIDTGYGDYSAVARYFTANGMGFAVVYDFPVGRNEYNQLGEYIVSTFKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIV2</accession>
    <name>F0LIV2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarate hydratase class I aerobic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01579"/>
    <dbReference type="EnsemblBacteria" id="ADT84554">
        <property type="protein sequence ID" value="ADT84554"/>
        <property type="gene ID" value="TERMP_01579"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01579"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1579"/>
    <dbReference type="eggNOG" id="arCOG04406">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098588_0_0_2"/>
    <dbReference type="OMA" id="IYHCGPL"/>
    <dbReference type="OrthoDB" id="88282at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase_C" evidence="3">
        <location>
            <begin position="3"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="174" mass="19141" checksum="A74861F2684D9F21" modified="2011-05-03" version="1">MDLKVPLGEKDVLKLKTGDIVYLSGIIYTARDLAHRRIVDLAKRGELPFSLEGATIYHCGPIVRKNKGEFEIVSAGPTTSTRMNRYLNEVLSLGVRGIIGKGGMIPEPFKKHSAVYFAFTGGAGSLAAKSIKKVRDVFWLDELGIPEAVWVLEVERFPLLVAIDAHGNSIYKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIZ0</accession>
    <name>F0LIZ0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466634.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00359"/>
    <dbReference type="EnsemblBacteria" id="ADT83336">
        <property type="protein sequence ID" value="ADT83336"/>
        <property type="gene ID" value="TERMP_00359"/>
    </dbReference>
    <dbReference type="GeneID" id="10040677"/>
    <dbReference type="KEGG" id="tba:TERMP_00359"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.359"/>
    <dbReference type="eggNOG" id="arCOG05908">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141525_1_0_2"/>
    <dbReference type="OMA" id="MPEFANP"/>
    <dbReference type="OrthoDB" id="111254at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="100" mass="11699" checksum="BB892C94281F1683" modified="2011-05-03" version="1">MLAEKPYLLGREKPLSKREIAQALRWAIEAELDAISFYEQLAELIEDERIKHIFYDVANEEKEHVGEFLAALLEVDEELVKYMKEGFEEVEEETGIKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ37</accession>
    <name>F0LJ37_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="10">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="10">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pheT</name>
        <name evidence="12" type="ordered locus">TERMP_00406</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="10"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466681.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00406"/>
    <dbReference type="EnsemblBacteria" id="ADT83383">
        <property type="protein sequence ID" value="ADT83383"/>
        <property type="gene ID" value="TERMP_00406"/>
    </dbReference>
    <dbReference type="GeneID" id="10040724"/>
    <dbReference type="KEGG" id="tba:TERMP_00406"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.406"/>
    <dbReference type="eggNOG" id="arCOG00412">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020279_3_0_2"/>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="OrthoDB" id="55024at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00284">
        <property type="entry name" value="Phe_tRNA_synth_beta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022918">
        <property type="entry name" value="Phe_tRNA_ligase_beta2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="11">
        <location>
            <begin position="279"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT83383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="559" mass="64465" checksum="AE8366B045F68F67" modified="2011-05-03" version="1">MPKFDVAKEDLERLIGKSFTVEEWEDLFLYAKCELDDIWEENGKIYFKADAKDTNRPDLWSAEGIARQIKWALGMKKGLPEYEVEKSDIVVYVDEKLKDIRPYGVYAVVENIRLDEEALKQLIQLQEKIALTFGRKRREVAIGTFDFDKLKPPFYYKAVEPDKIKFIPLNCEEEMTADEILEKHEKGQEYGHLIKGKPYYPLLIDSEGNVLSMPPVINSETHGKVTEKTRNIFIDITGWNLNKIMLALNVLVTALAERGGKIKSVKVVYKDFEIETPDLTPKEFEVELSYIKKLAGIELSDEQIKELLERMFYEVDLKDGKAKLKYPAFRDDIMHARDVLEDVLIAYGYNNIEPEEPKLAVQGKGNDFIEFENAIRELMIGFGLQEVMTFNLTNKEAQFTKMNIPEEEIVEIENPVSLRWSALRKWLLPSLMEFLSLNTHEEYPQKIFEVGKATLIDETRETKTVSESKLAVVIAHPRVTFTEVKEILDSIMHHLGFEYELEETEHGSFIPGRVGKIVVEGKEVGIIGEIHPQVLENWGIEMPVAAFEIFLRPLYKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ58</accession>
    <name>F0LJ58_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(R)-2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467878.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01605"/>
    <dbReference type="EnsemblBacteria" id="ADT84580">
        <property type="protein sequence ID" value="ADT84580"/>
        <property type="gene ID" value="TERMP_01605"/>
    </dbReference>
    <dbReference type="GeneID" id="10041921"/>
    <dbReference type="KEGG" id="tba:TERMP_01605"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1605"/>
    <dbReference type="eggNOG" id="arCOG04874">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040452_2_0_2"/>
    <dbReference type="OMA" id="TNTEPAM"/>
    <dbReference type="OrthoDB" id="32318at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="PTHR11091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="SSF89733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="364" mass="40094" checksum="E3E78D33AE083104" modified="2011-05-03" version="1">MFEKGYIDENYVRVSRDELFSFVVKVLMKLGVPKEDAEIVADNLIMADLRGIESHGVQRLKRYVDGILSGGINLKPNIRIVREGASYALIDGDEGLGQVVGYKAMKLAIEKAKKSGIGVVVVRNSNHYGIAGYYALMAAVEGMIGISMTNSRPLVAPTGGVERFLGTNPIALAAPTKDKPFLLDMATSVVPIGKLEVYRRKGKPIPEGWAIDSEGNITTDVEKVFNGGALLPLGGFGELFGGHKGYGLSVMVDILAGILSGGTWSRHVKNTSERHSEVDHFFMAINIEAFVPLEEFKEKMSRMIEELKSSKRHKDFERIWIHGEKGFLTMQTRLKIGIPIYKKVLEELNQIAEMVGVEKLKVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ82</accession>
    <name>F0LJ82_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01629"/>
    <dbReference type="EnsemblBacteria" id="ADT84604">
        <property type="protein sequence ID" value="ADT84604"/>
        <property type="gene ID" value="TERMP_01629"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01629"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1629"/>
    <dbReference type="HOGENOM" id="CLU_2784307_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="68" mass="8020" checksum="98F9EF2925B6511B" modified="2011-05-03" version="1">MRIKPELKTYRVWTLREPKSLRAFLWKENQGLRVIATLNITAKIIGKRNPDMAPISKRFSDFTFIPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJE2</accession>
    <name>F0LJE2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466706.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00431"/>
    <dbReference type="EnsemblBacteria" id="ADT83408">
        <property type="protein sequence ID" value="ADT83408"/>
        <property type="gene ID" value="TERMP_00431"/>
    </dbReference>
    <dbReference type="GeneID" id="10040749"/>
    <dbReference type="KEGG" id="tba:TERMP_00431"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.431"/>
    <dbReference type="eggNOG" id="arCOG04692">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082635_0_0_2"/>
    <dbReference type="OMA" id="FNTFYLG"/>
    <dbReference type="OrthoDB" id="46460at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="242" mass="27945" checksum="2557A9A638E5C283" modified="2011-05-03" version="1">MTELKWLIFDVDGVLIDVSESYDLATKLTVEYFLKKLDKSIEIELDLIRTLRRKGAFGDDFKVSEALIIGVLTGDLRSFVQNFPAGEGISWVRKQFGVVIDPKTIERIFNTFYLGEHYKERAFDFEGLWKKEKPIVKKELLEKANERFKLGIITGRSALELELAEKIVGFHFKNAVTRELYVKPDPKALWHLTKGEKGIYIGDTINDELLVKNYKKAYGKDFNFLMVGRDIKDVNELLQSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJF5</accession>
    <name>F0LJF5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative abhydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466719.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="SMR" id="F0LJF5"/>
    <dbReference type="STRING" id="391623.TERMP_00444"/>
    <dbReference type="ESTHER" id="9eury-b5itw3">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83421">
        <property type="protein sequence ID" value="ADT83421"/>
        <property type="gene ID" value="TERMP_00444"/>
    </dbReference>
    <dbReference type="GeneID" id="10040762"/>
    <dbReference type="KEGG" id="tba:TERMP_00444"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.444"/>
    <dbReference type="eggNOG" id="arCOG01648">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_3_2"/>
    <dbReference type="OMA" id="AHKKLWF"/>
    <dbReference type="OrthoDB" id="35407at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="25"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="269" mass="30427" checksum="062ACDD15A86A20A" modified="2011-05-03" version="1">MPFIKVDGIKIHFYDSGKAVEENLPALLFLHGSPGQISNWKHILPCFEGSYRVVAVDLRGYGKSDKPLNVALEDYIRDIDAIRSELGLENIVLIGHSFGAMIAIEYAARRHVNGVVLIGPVAYLKTDAIDKIIMHLPPAIWKPILFKSNLLTRRMYRKMFFSPSTPDEVFLEFMKDNKDYIESLPPQSFRYLIHLAGYNAKPSAERVKVPTLIIVGEDDVVTPPEHAKLIHKWVENSKLVIIPKAGHLVLYEKPGEICRLIKEFIKGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJF9</accession>
    <name>F0LJF9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HSDR_N_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466723.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00448"/>
    <dbReference type="EnsemblBacteria" id="ADT83425">
        <property type="protein sequence ID" value="ADT83425"/>
        <property type="gene ID" value="TERMP_00448"/>
    </dbReference>
    <dbReference type="GeneID" id="10040766"/>
    <dbReference type="KEGG" id="tba:TERMP_00448"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.448"/>
    <dbReference type="eggNOG" id="arCOG05724">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076815_0_0_2"/>
    <dbReference type="OMA" id="WNNPEEV"/>
    <dbReference type="OrthoDB" id="82306at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029464">
        <property type="entry name" value="HSDR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13588">
        <property type="entry name" value="HSDR_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSDR_N_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="289" mass="33630" checksum="5B8B3527A01D3C1D" modified="2011-05-03" version="1">MDKIERAILDVLKKVNEHRKLYERNEEAVKQHLIGEVFQALGWEWNNPKEVRPEERTDEGRADYALITGNRVVAFVEAKNLSINVLKKEKPLRQLGRYCFNNGVKYGILTNGVAWVVIKAFEEGSRLEDRIILSVDIENEPIERTTLKLSLLSKSRIEKLERFATLLRALEFSFDELKREGISERKLIEFLTASKKRLLTLEKLRGDELPRALYIYDNGWKIVPLVERSIKGILLSLLLYLSEKSEGEEKAQIKKAYAYLKEMPIDTQKILRLLHEIEKEKGIRIGIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJK6</accession>
    <name>F0LJK6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00495"/>
    <dbReference type="EnsemblBacteria" id="ADT83472">
        <property type="protein sequence ID" value="ADT83472"/>
        <property type="gene ID" value="TERMP_00495"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00495"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.495"/>
    <dbReference type="HOGENOM" id="CLU_3194688_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="45" mass="5348" checksum="190B3EB26DFD436F" modified="2011-05-03" version="1">MPIAMKKKNPHAKYIHSMLKEEALDLTVYLWSDENSMRRSKNITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJL9</accession>
    <name>F0LJL9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467959.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01686"/>
    <dbReference type="EnsemblBacteria" id="ADT84661">
        <property type="protein sequence ID" value="ADT84661"/>
        <property type="gene ID" value="TERMP_01686"/>
    </dbReference>
    <dbReference type="GeneID" id="10042002"/>
    <dbReference type="KEGG" id="tba:TERMP_01686"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1685"/>
    <dbReference type="eggNOG" id="arCOG00751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_2"/>
    <dbReference type="OMA" id="TFVVIQF"/>
    <dbReference type="OrthoDB" id="61149at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="124"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="353" mass="39303" checksum="95B0B94B277659D3" modified="2011-05-03" version="1">MGYGRYLAIRLLNALLVLALVTLLVSVLFTKVAEEDLKSSIQEQINMKLRANPELMKQLSADPERFQQWYQNEYNRLIRAYGLDKPFWVRVLERTKDTLTLNFGNTKTPIFGETNVKKIIAAAIPRTVLLFTTAQIIVILIGLLLGVKAAQVAGSALDRAVSIIAMLTSSIPMWWFGMIAILIFSFKLGWFPSGGMTSTPPKEGFAYYTDILYHMVLPVGTIVFVLFGGWAWTTRNIMIGTMQEDFIMAARAKGVPERKVIYGHALRASAPPIITMTIFSLLGSLGGAIITEGVFNWPGMGRLYWTALQQNETRLLMGVTFVTVALYLISMILADLAYGYLDPRVKVGASQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJR5</accession>
    <name>F0LJR5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1648 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468005.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01732"/>
    <dbReference type="EnsemblBacteria" id="ADT84707">
        <property type="protein sequence ID" value="ADT84707"/>
        <property type="gene ID" value="TERMP_01732"/>
    </dbReference>
    <dbReference type="GeneID" id="10042048"/>
    <dbReference type="KEGG" id="tba:TERMP_01732"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1731"/>
    <dbReference type="eggNOG" id="arCOG04484">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06110">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090556_0_0_2"/>
    <dbReference type="OMA" id="GEPDNFA"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012867">
        <property type="entry name" value="DUF1648"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026272">
        <property type="entry name" value="SdpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025962">
        <property type="entry name" value="SdpI/YhfL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37810:SF5">
        <property type="entry name" value="PTHR37810:SF5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07853">
        <property type="entry name" value="DUF1648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13630">
        <property type="entry name" value="SdpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1648" evidence="2">
        <location>
            <begin position="137"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="271" mass="30163" checksum="BAF0B08FDB407764" modified="2011-05-03" version="1">MAGIEVFNMMFEIFIAFLMFVSGLLTYIFRNKPNTAIGFRFGYTFSSKEAWVKVNTFGGKAFMAFGVLLFVLSLKVRNILIFFIVMIAGVLLITTYGYKMAREIVEKESLREPAFGEPKPVEGINVKPYLAIQIGALAFSIIFLVLSWDRLPEIVAIHFNIAGEPDNFAQKTLGVFLFPLAASLLPIALTYMAKDPMMLRTAPKMSKKGLKILAEMMTIIAIMLAWANVYLILYNAYNFHSNALLSATLLGGIGLLLIETFRLLLAAGTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJT3</accession>
    <name>F0LJT3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01750"/>
    <dbReference type="EnsemblBacteria" id="ADT84725">
        <property type="protein sequence ID" value="ADT84725"/>
        <property type="gene ID" value="TERMP_01750"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01750"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1749"/>
    <dbReference type="HOGENOM" id="CLU_803203_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="345" mass="39556" checksum="54B824B0C8B3DB91" modified="2011-05-03" version="1">MRLLKLIFVGLLMTLLPLVQGEISGNITIENKPHIGATLIFRITLFPDIDGRVLVSAVYFDGMDITSEVLSGKGSLGFLTEKEIIFEHSGDYDSTFLYLRLKRTLAEKLYGRTFSGISDYRFLLSDKNHTIKVIFSNGYALQKTFYVPPETQRDIPTYFGVSFVGLFFLFEIFRHKPSEVRAHVYFILLGTLLFFLLLLDRIIVVQNYFDFADNLLNILSVYIFLHLIYLFVWFQRGVKSGYSGIFVIPMIPILGVAYHFFGAAAFVVFGIMLLIVWDREVSDGISPKTALLLNVLYTIMGLIFANYFGAKPFSARLFFAIASIYTVLIFKYREYVYASVRRDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJU7</accession>
    <name>F0LJU7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">thiE</name>
        <name evidence="12" type="ordered locus">TERMP_00507</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8 9">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8 9">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8 10">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
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        <property type="protein sequence ID" value="ADT83484.1"/>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
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        <property type="protein sequence ID" value="ADT83484"/>
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    <dbReference type="KEGG" id="tba:TERMP_00507"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.507"/>
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        <property type="reaction ID" value="UER00141"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:magnesium ion binding"/>
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        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
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    </dbReference>
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        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="11">
        <location>
            <begin position="9"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADT83484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="209" mass="22830" checksum="939440A88FF3933D" modified="2011-05-03" version="1">MNLKKRLRLYVITDRRLRDEIETTKAALEGGATAIQMRIKNAPTGEMVRVGKELRKITKEYGALFFVDDRLDVALAVDADGVQLGPEDMPVYIARELAPNLIIGASVYSLEEALKAEREKADYLGAGSVFPTKTKKDARVLGLEGLKKVVESVKIPVVAIGGINHENVRKVLEIGVDGIAVISAIVGAEDVKKAAEEMRRIIDEYLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJV3</accession>
    <name>F0LJV3_THEBM</name>
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        <submittedName>
            <fullName evidence="7">Ribose ABC transport system RbsC-like permease protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ordered locus">TERMP_00513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
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        <lineage>
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            <taxon>Thermococcales</taxon>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="32"/>
            <end position="54"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="155"/>
        </location>
    </feature>
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        <location>
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            <end position="209"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="301" mass="32124" checksum="E198B26DACB86AB0" modified="2011-05-03" version="1">MIDMVVSILLGSLTAMVPIVLTSTGAVVSERAGVVNIGYEGILLMAALFGAMFAETSGNAWIGLLGGAFIGMLLGMLHGAITVYLKGDHIIPGIGVNILALGVVAFGIPAIWGTAGQHQVPTNFRIQPLINTQYGSLSPMIPITFAIVFITHWVLFNTPLGLRIRAVGENPEAADALGVNVERYRFLATVYGATLAGLGGAYLSVDWLGVVTKEISSGRGFIALANMVFSGWNPVRALIGGFIFGFFDNLSVWVRTNPAISQIIPWQFVATLPYIVTIIIVAGIIGKVRPPKWDGRPYKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJW1</accession>
    <name>F0LJW1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">TERMP_00521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83498.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00521"/>
    <dbReference type="EnsemblBacteria" id="ADT83498">
        <property type="protein sequence ID" value="ADT83498"/>
        <property type="gene ID" value="TERMP_00521"/>
    </dbReference>
    <dbReference type="GeneID" id="10040839"/>
    <dbReference type="KEGG" id="tba:TERMP_00521"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.521"/>
    <dbReference type="HOGENOM" id="CLU_031185_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011470">
        <property type="entry name" value="DUF1576"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07613">
        <property type="entry name" value="DUF1576"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="410" mass="43941" checksum="13F2AB8508304FA1" modified="2011-05-03" version="1">MNRLSLRFYILLTLPLLMIVAAFLLDTPENMIKGLKAIVLHSDVLLVDYLAVGGIGATLINSALLTLANVYLLYRLKIEPTGPIIAAVLTIAGFAFMGKNIINVWPIYVGGYLYTRYKGTSFKSVILIMMFATTLAPLVTELLISPSLGKFGFIAGFLGGVIVGFIMPPLSAHMLRVHDGYNLYNIGFTGGLLGGVLMAVKRGLGIEPEKQFILSSEYDLELKILLSAFFLFLLFLGVYLNGRSLRGYRRIMKLNGRIVTDFVQLEGFEVSLINMGIMGLMGLAVVALAKSPVNGPVVAGLLTLVGFSAFGKHPLNSLPVILGIFLGEILIFKNIHPTVLAITALFGTTLAPIAGSFGALAGIAAGMLHMFVVLNVGYLHGGINLYNNGFSGGIVATILVPILRAFGKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK02</accession>
    <name>F0LK02_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00562"/>
    <dbReference type="EnsemblBacteria" id="ADT83539">
        <property type="protein sequence ID" value="ADT83539"/>
        <property type="gene ID" value="TERMP_00562"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00562"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.563"/>
    <dbReference type="eggNOG" id="arCOG00272">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082650_1_0_2"/>
    <dbReference type="OMA" id="WAILWAY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="124"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="261" mass="28803" checksum="EFA30B0978A2EF4E" modified="2011-05-03" version="1">MRNKSAITVNIVRLYIIAVVYAVFFMVNGNWREVLNLTPLQLMVAFVSAQFGFVIGDYFFFNAMKIMGVSRTVPITSSYPLWAILWAYLFLGRNIRPQIIFGAFLIVLAIIIVRQGEIEEHLDMKGFVFALLAPLSWSFAIITMEWLSAQISPFTLAGLRMMFAALGISVFLKRYEGEIKEITRRELTALAGAAFLGLFIGQYSFVKAVSLVGSPIAAPVSSINPIISATLAILILREPPNSKILTGLVMAVIGVILISTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK03</accession>
    <name>F0LK03_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466838.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00563"/>
    <dbReference type="EnsemblBacteria" id="ADT83540">
        <property type="protein sequence ID" value="ADT83540"/>
        <property type="gene ID" value="TERMP_00563"/>
    </dbReference>
    <dbReference type="GeneID" id="10040881"/>
    <dbReference type="KEGG" id="tba:TERMP_00563"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.564"/>
    <dbReference type="eggNOG" id="arCOG05737">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035109_0_0_2"/>
    <dbReference type="OMA" id="PRVTFKW"/>
    <dbReference type="OrthoDB" id="21372at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="599" mass="68114" checksum="77E44BF988788CFD" modified="2011-05-03" version="1">MQLPKMQPFKENIVSTSKDDFVSLIREALADANGTFIKIFTKDSNEKYYFTVLTDNSKILAAYGKFLIANRDVIGKEALDALRLLLSNPMVVDVYTLDEITLKLSIADNIEIYSATPKIGIEEFLGVPKQSEFSEVLEKEKLLEQVLEKVKREERIKPAPQIEKVKEVKKAKVPEIIEKPREEKPLKVPKEVPKPASQKVAKKEELKVKIEIIGSEAFKPALEEAFKEYSKVLLNEIKKMNDTVLNDVEIRGEIGTGVVYLTIQLNANVGDEKSIEIAKRKILFFANRHIPVIGRVSGLKPIIRTVKVNVIAGEKVDTMEEKERGEVELWRLKKPPTVQVTPKISLTIDPEFRTYFSAYSKALLRDIEDAGIRVEKMEVEVEGRKEHEINIKLHASAANMSRIQIESFVTALAKKHAREIGKALKKYVWVHRVEVESIMPQQPSSVMESQVSTKAAEILKKKSEIEKEVEKLLKEAGIEELSFLTEDKKKDVEQTLLKSRIEPAMETLKSRVQNDLKLLPRVTFKWLKMNWNFTGSNVEVIFEVSFAKEEVGGLFGTFSGISDDKIKEDAIKTIKKAMEDVSREYGINIVPKRINVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK65</accession>
    <name>F0LK65_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ordered locus">TERMP_01802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468073.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01802"/>
    <dbReference type="EnsemblBacteria" id="ADT84777">
        <property type="protein sequence ID" value="ADT84777"/>
        <property type="gene ID" value="TERMP_01802"/>
    </dbReference>
    <dbReference type="GeneID" id="10042118"/>
    <dbReference type="KEGG" id="tba:TERMP_01802"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1801"/>
    <dbReference type="eggNOG" id="arCOG01348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_3_2"/>
    <dbReference type="OMA" id="VNLGHVG"/>
    <dbReference type="OrthoDB" id="104144at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="178"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="278" mass="31162" checksum="660474758E8C1CC1" modified="2011-05-03" version="1">MKFGVVARRDKEAALKLAYRVYDFLKVSGFDVFVDEETYQHFPHFSVEDVVKLEDMDVDFIIAIGGDGTILRIEHRTKKDIPILGINMGTLGFLTEVEPNEAFFAINKLIEGDYHIDERIKLRTYLNGENTVPDALNEVAILTGVPGKIVHLKYYVDEGLADEVRSDGLIISTPTGSTGYAMSAGGPFLDPRIDGVVIAPLAPIALSSRPMVVPATSKIDVRILTLTRNVILAIDGQFYTYLTPDIEITIKKSPRKTKFIRFSEEIYPKYTLKIKKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK69</accession>
    <name>F0LK69_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468077.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01806"/>
    <dbReference type="EnsemblBacteria" id="ADT84781">
        <property type="protein sequence ID" value="ADT84781"/>
        <property type="gene ID" value="TERMP_01806"/>
    </dbReference>
    <dbReference type="GeneID" id="10042122"/>
    <dbReference type="KEGG" id="tba:TERMP_01806"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1805"/>
    <dbReference type="eggNOG" id="arCOG03787">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059309_1_0_2"/>
    <dbReference type="OMA" id="QWGYVDE"/>
    <dbReference type="OrthoDB" id="50807at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009269">
        <property type="term" value="P:response to desiccation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004864">
        <property type="entry name" value="LEA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013990">
        <property type="entry name" value="WHy-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03168">
        <property type="entry name" value="LEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00769">
        <property type="entry name" value="WHy"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="WHy" evidence="2">
        <location>
            <begin position="29"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="WHy" evidence="2">
        <location>
            <begin position="162"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="297" mass="33268" checksum="66FE5BDEEF30E7D6" modified="2011-05-03" version="1">MRIVKIIAVLFLIFILWLGYLGYAALNLKPKITAEWGYVDDKTTELWLHIDLGKKLPIALRVDNVTIEWAGVKIGKVENMKLGFMQDKVDGVLILDNYKAVEALKNHIRGGEKSYVKIALGVSIFGILVFKKEFTQQVKTDILSQFNIKTESTGDLIKTPAVEGISSRWGPVGDKYITVYSDVKLYNPNSFPIPVSGVEFNVNIDNYPVATGTLVENTVLPANGYGVVKVKTLLDTSVLPKVWAEHIKRGEESDVSVIIYLKANVLNKEFRIKVADIEKKIKTNIIEQINSMLELKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK94</accession>
    <name>F0LK94_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468102.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84806">
        <property type="protein sequence ID" value="ADT84806"/>
        <property type="gene ID" value="TERMP_01831"/>
    </dbReference>
    <dbReference type="GeneID" id="26137346"/>
    <dbReference type="KEGG" id="tba:TERMP_01831"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1830"/>
    <dbReference type="eggNOG" id="arCOG05774">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2613817_0_0_2"/>
    <dbReference type="OMA" id="EEVHGII"/>
    <dbReference type="OrthoDB" id="116345at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="77" mass="8672" checksum="E2B35EE9B9BC1A28" modified="2011-05-03" version="1">MSAIMIGQDKFKISEDEVAKRELKVIKVSDDVIQVQEEIHGIIALVGATSTVNIKKEELKNLIKVVKEEFGWTDICE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKD5</accession>
    <name>F0LKD5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyruvate/ketoisovalerate oxidoreductases common subunit gamma</fullName>
            <ecNumber evidence="5">1.2.7.1</ecNumber>
            <ecNumber evidence="4">1.2.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_00616</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:11712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="EC" id="1.2.7.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:12765"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="1.2.7.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterotetramer of one alpha, one beta, one delta and one gamma chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.1" evidence="5"/>
    <dbReference type="EC" id="1.2.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466891.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00616"/>
    <dbReference type="EnsemblBacteria" id="ADT83593">
        <property type="protein sequence ID" value="ADT83593"/>
        <property type="gene ID" value="TERMP_00616"/>
    </dbReference>
    <dbReference type="GeneID" id="10040934"/>
    <dbReference type="KEGG" id="tba:TERMP_00616"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.618"/>
    <dbReference type="eggNOG" id="arCOG01602">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_0_0_2"/>
    <dbReference type="OMA" id="EVSWMPS"/>
    <dbReference type="OrthoDB" id="76505at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043807">
        <property type="term" value="F:3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011894">
        <property type="entry name" value="PorC_KorC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02175">
        <property type="entry name" value="PorC_KorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="8">
        <location>
            <begin position="11"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="188" mass="20579" checksum="DD3BBD96DD57F64F" modified="2011-05-03" version="1">MRKEVLISGFGGQGVILASVILGRAAAVYEGLYAVQTQSYGPESRGGASKAEVVISDEPIDYPKTLRPDYAVFLSQEAYQKYLTHLKENAILIIEKDLIPHRNEEVEKKLKLKVYALPLTKIAEETTGLSLTMNILALGLFVALTEIVSREAIEKAVLDAVPKGTEQINLKALHKGFELGEKALKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKF2</accession>
    <name>F0LKF2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466908.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00633"/>
    <dbReference type="EnsemblBacteria" id="ADT83610">
        <property type="protein sequence ID" value="ADT83610"/>
        <property type="gene ID" value="TERMP_00633"/>
    </dbReference>
    <dbReference type="GeneID" id="10040951"/>
    <dbReference type="KEGG" id="tba:TERMP_00633"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.635"/>
    <dbReference type="eggNOG" id="arCOG10341">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2406502_0_0_2"/>
    <dbReference type="OrthoDB" id="142306at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="92" mass="10646" checksum="1FFAAD781FD69503" modified="2011-05-03" version="1">MSLLPLAGMFIFGGKKKEEEDIYAKLARKYGLTRDQVRKIGFLIVRGTRNIPKLLKRVDPEQDEKRIHKVLEAVKHVDDTGEPYIYKEHGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKG3</accession>
    <name>F0LKG3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466919.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00644"/>
    <dbReference type="EnsemblBacteria" id="ADT83621">
        <property type="protein sequence ID" value="ADT83621"/>
        <property type="gene ID" value="TERMP_00644"/>
    </dbReference>
    <dbReference type="GeneID" id="10040962"/>
    <dbReference type="KEGG" id="tba:TERMP_00644"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.646"/>
    <dbReference type="eggNOG" id="arCOG04337">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074390_5_0_2"/>
    <dbReference type="OMA" id="DIVIYPS"/>
    <dbReference type="OrthoDB" id="101563at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd05126">
        <property type="entry name" value="Mth938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034096">
        <property type="entry name" value="AAMDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="SSF64076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="117" mass="13430" checksum="EC0197D29AD9D8CF" modified="2011-05-03" version="1">MIDSVRFGEIVVQGKEYPYDIVIYPSGKIERRKKELSKKKHGTSHKFDPDELKDYLREDFDILIVGTGIYGALRLLPEAKELVKGKEIVEKPTPEAIKLFNELRKGKKVLGVFHITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKI2</accession>
    <name>F0LKI2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468112.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01841"/>
    <dbReference type="EnsemblBacteria" id="ADT84816">
        <property type="protein sequence ID" value="ADT84816"/>
        <property type="gene ID" value="TERMP_01841"/>
    </dbReference>
    <dbReference type="GeneID" id="10042157"/>
    <dbReference type="KEGG" id="tba:TERMP_01841"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1840"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_3_2"/>
    <dbReference type="OMA" id="QVHAVNI"/>
    <dbReference type="OrthoDB" id="39139at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="163"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="342" mass="38962" checksum="29589A727E513EE0" modified="2011-05-03" version="1">MPDRKLRVGVVGCGNIFNLAHKNALKNLETVKPVAFMDIRIKKAKEAAKEFNAKYFTSLDEFLDFDLDVVEILTPTYTHADIAIKALKAGKHVIVEKPIALRSEEAEKMIKVAEKEGLWLLVGHTRRFDKRWMQIKEIIKKRNILPMQIRKAEVQRLPFPETAWYWKPHKGGGVAIDLGVHVTDFLRWFFESEAVKVLGIGKAIRKEAKVNNTYDHFVMMIQFEGGKTGIAEVSWAYSYPARYGVFYHHLDILGKNGRIRFTPMDTPVVGVVKSHFEMPRFSPMLSTFPDAFERELRHFFNVILGKEEPVITAKDALIALQIAETAIKSAQKGEPIELGVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKN5</accession>
    <name>F0LKN5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type tungstate transport system periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468165.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01894"/>
    <dbReference type="EnsemblBacteria" id="ADT84869">
        <property type="protein sequence ID" value="ADT84869"/>
        <property type="gene ID" value="TERMP_01894"/>
    </dbReference>
    <dbReference type="GeneID" id="10042210"/>
    <dbReference type="KEGG" id="tba:TERMP_01894"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1893"/>
    <dbReference type="eggNOG" id="arCOG00229">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061511_0_0_2"/>
    <dbReference type="OMA" id="LADRGTW"/>
    <dbReference type="OrthoDB" id="49385at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="31"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="342" mass="37986" checksum="01CC35D2009E031D" modified="2011-05-03" version="1">MNKRLKLGFLLALILVSFSYGCIGNSNEVATAKPKVLTISTTTSLYDTGILENVVAPIFKEKYNIELRFIPKGTGGAILDAKSGASDAILVHALPKEQAFMEEGYGVNRKVFAYNFFVIVGPKDDPAGIRGLSVSEALKKIVEYGRAHPDKIVWVSRDDGSGTNTKEIALWKNAGFDFNELKNESWFGTTGAGMGNTLLYTSERKAYTISDIGTYLKYQKEGKINLDVLVDKGEELINVYAIIIINPKKIPGKDFKDAMLLAEWLTSDEGQKAIAEYGKDEFGRPLFYPAVPVLKGEQGDVFRWILKYGFMKDGDKYTECPEKFRYNATYDFFEFPASVVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKP3</accession>
    <name>F0LKP3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468173.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84877">
        <property type="protein sequence ID" value="ADT84877"/>
        <property type="gene ID" value="TERMP_01902"/>
    </dbReference>
    <dbReference type="GeneID" id="26137438"/>
    <dbReference type="KEGG" id="tba:TERMP_01902"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1901"/>
    <dbReference type="eggNOG" id="arCOG00981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098197_2_0_2"/>
    <dbReference type="OMA" id="FGQTEDH"/>
    <dbReference type="OrthoDB" id="91048at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="159" mass="17631" checksum="25617E5202A16825" modified="2011-05-03" version="1">MKVEKGDFVVFNYVGRFEDGEVFDTSYEDIAKEAGIYVEDRKYQPIGANVGVGELIPGLDEALIGMEVGEKKTITIPPELGYGMPKEELIINVPRSDFENAGIEPVKDMYVMTDSGIARIAEVGEENVTLDFNHPLAGKTLIFEVEIIDIQKAEEKQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKQ5</accession>
    <name>F0LKQ5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466932.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00657"/>
    <dbReference type="EnsemblBacteria" id="ADT83634">
        <property type="protein sequence ID" value="ADT83634"/>
        <property type="gene ID" value="TERMP_00657"/>
    </dbReference>
    <dbReference type="GeneID" id="26136057"/>
    <dbReference type="KEGG" id="tba:TERMP_00657"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.659"/>
    <dbReference type="eggNOG" id="arCOG01218">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082677_0_0_2"/>
    <dbReference type="OMA" id="RMAHKFA"/>
    <dbReference type="OrthoDB" id="67467at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011903">
        <property type="entry name" value="Glutaredoxin-like_bact/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02187">
        <property type="entry name" value="GlrX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="96"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="224" mass="25533" checksum="41A8C648C035B112" modified="2011-05-03" version="1">MGLISDGDKKVIREEFFSKLTNPVKLIVFIGKDHCQYCEQLKQLVQEISELSDLVSFEVHDFDTEKELAQRYRVDRAPVTVITQDGKDFGVRYFGLPAGHEFGAFLEDIVDVSNGTTDLMKETKETLKEIDRDVRILVFVTPTCPYCPMAVRMAHKFALENALAGKNKILGDMVEAIEYPEWADQYRVMAVPKIVIQVDGVDKVEFEGAYPEKMFLEKLLEALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKT5</accession>
    <name>F0LKT5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holliday junction resolvase Hjc</fullName>
            <shortName evidence="10">Hjc</shortName>
            <ecNumber evidence="10">3.1.21.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hjc</name>
        <name evidence="11" type="ordered locus">TERMP_00687</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Holliday junction resolvase Hjc family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="10"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466962.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00687"/>
    <dbReference type="EnsemblBacteria" id="ADT83664">
        <property type="protein sequence ID" value="ADT83664"/>
        <property type="gene ID" value="TERMP_00687"/>
    </dbReference>
    <dbReference type="GeneID" id="26136089"/>
    <dbReference type="KEGG" id="tba:TERMP_00687"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.688"/>
    <dbReference type="eggNOG" id="arCOG00919">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139546_2_0_2"/>
    <dbReference type="OMA" id="WYFFHPG"/>
    <dbReference type="OrthoDB" id="97278at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00523">
        <property type="entry name" value="archeal_HJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01490">
        <property type="entry name" value="HJ_Resolv_Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002732">
        <property type="entry name" value="Hjc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014428">
        <property type="entry name" value="Hjc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39651">
        <property type="entry name" value="PTHR39651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01870">
        <property type="entry name" value="Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004985">
        <property type="entry name" value="Hlld_jn_rslvs_ar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="134" mass="15322" checksum="0D05B4647C11E0A7" modified="2011-05-03" version="1">MRYRKGASAERELIKMLEKEGFAVIRSAGSKKVDIVAGNGKLYFCIEVKSTKGEKLYVNAEDVDKLMNFAEKFGGKAIIAVKFISNGWYFFYPNQLTKSGKNYKISLRDARYKGLRFDEIVGKQMSLDEVIKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKU1</accession>
    <name>F0LKU1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00693"/>
    <dbReference type="EnsemblBacteria" id="ADT83670">
        <property type="protein sequence ID" value="ADT83670"/>
        <property type="gene ID" value="TERMP_00693"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00693"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.694"/>
    <dbReference type="eggNOG" id="arCOG00202">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="QVHKYYG"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="280" mass="31236" checksum="62B1FAEC0C96695A" modified="2011-05-03" version="1">MLIRVEDLSFRYSRAKEYSIKNINLKIRKGEFVGILGPSGSGKSTLCLTFNGIIPHSIRGELRGDVYVKGYNTKETSVAKLSTIVGLVLQNPDSQLFNMTVEEEVAFGLENLGLDPEEIKRRIKWALRIAGLEGLENEFPPNLSGGQKQRLAIASVLAMKPEVLVLDEPTSQLDPLGREQVLSLITLLNKEQGITIVLVEHNTEYILSFADRVVVLDKGEIVLEGKPKNVFEEVELLQNLGIRLPASVRISHKLKKKGLLERSALSERELINKLKSIMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKW1</accession>
    <name>F0LKW1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83690">
        <property type="protein sequence ID" value="ADT83690"/>
        <property type="gene ID" value="TERMP_00713"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00713"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.715"/>
    <dbReference type="HOGENOM" id="CLU_3264013_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="41" mass="4625" checksum="963CCC9204E87481" modified="2011-05-03" version="1">MKSLIRSFGISVDRVAVYVDVFGDDIVFCMEVAKVWEVGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKX1</accession>
    <name>F0LKX1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoesterase</fullName>
            <ecNumber evidence="1">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466998.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00723"/>
    <dbReference type="EnsemblBacteria" id="ADT83700">
        <property type="protein sequence ID" value="ADT83700"/>
        <property type="gene ID" value="TERMP_00723"/>
    </dbReference>
    <dbReference type="GeneID" id="10041041"/>
    <dbReference type="KEGG" id="tba:TERMP_00723"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.725"/>
    <dbReference type="eggNOG" id="arCOG01145">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_5_0_2"/>
    <dbReference type="OMA" id="AVPGNCD"/>
    <dbReference type="OrthoDB" id="49505at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07392">
        <property type="entry name" value="MPP_PAE1087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041733">
        <property type="entry name" value="PAE1087_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="214" mass="24198" checksum="961F5BC88B903127" modified="2011-05-03" version="1">MRIIAITDIHGNENKVKWLVEKIKDEKFDVLLIAGDITHFKGRNSAEKSLKYLLELKKPVYAVMGNCDGRDVLDLLEELGINLHDKRIEINGIGIVGFGGSNITPFSTIWEFHDDEIWESLNKNYRDGDILLMHVPPYKTKVDKTFTGLHVGSKALRKFIEEKQPPLVICGHIHEARGVDEIGKTLIVNPGPLFRGHYAVIDINEGKKVSITLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL29</accession>
    <name>F0LL29_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_01962</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01962"/>
    <dbReference type="EnsemblBacteria" id="ADT84936">
        <property type="protein sequence ID" value="ADT84936"/>
        <property type="gene ID" value="TERMP_01962"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01962"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1960"/>
    <dbReference type="eggNOG" id="arCOG00905">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044815_1_3_2"/>
    <dbReference type="OMA" id="RPWLIAE"/>
    <dbReference type="OrthoDB" id="90493at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="31"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT84936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="194" mass="22263" checksum="A524294B10BCDB2E" modified="2011-05-03" version="1">MAKDELMKKLEERIRNCKKCPLSALRTNAVPGSGSYDAKVMFVGEAPGYWEDQKGLPFVGRAGKVLDELLSEIGLKREDVYITNIVKCRPPNNRDPNEDEIKACSPYLDRQIDIIRPKIIVPLGRHSMSYILRKFGFEAEPISRIHGKTFEARTLFGKVIIMPMYHPAVALYRPQLKEELRKDFKKLKNVLMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL69</accession>
    <name>F0LL69_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TldD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467018.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00743"/>
    <dbReference type="EnsemblBacteria" id="ADT83720">
        <property type="protein sequence ID" value="ADT83720"/>
        <property type="gene ID" value="TERMP_00743"/>
    </dbReference>
    <dbReference type="GeneID" id="10041061"/>
    <dbReference type="KEGG" id="tba:TERMP_00743"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.745"/>
    <dbReference type="eggNOG" id="arCOG00321">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_2_2"/>
    <dbReference type="OMA" id="MLYADYV"/>
    <dbReference type="OrthoDB" id="22382at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="114"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="230"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="456" mass="50980" checksum="F040E8BE59E6D025" modified="2011-05-03" version="1">MQDVLEKALEWAMNNLKAEYIELRYENLKKTNLELKDGTFVTFTNKVQRGVAIRVLADGAWGFSSTNRLENLEKAIEEAYKLAKAGAKAKREKIQLAEIKPVEDVVKSKMKIKPVEVNIDDKIGHLRELEKLLKEDKAVKSTMIRYEDASGEKILLTNEGANIRWDVNYLVQYIWATGKEGDKLAASRDSIGQVDYGWEIFETRETNEVVAQRVLKKLHAQLNGVAPKRGEFPIVAGPIIVGIIAHEALGHLAEADLTINSPFKDLMGKQIAPEFVTMSERIVDGGFGNDKYDDEGVPVRDIHIIENGILKELMVNREYAHKWGIEPNGHARAQDYTFPPIIRMRNTVFEPGDWSFEEMIEDIKFGYYVVDFRGGQAQLNSAFQVGVQEGYMIENGEITKPIRDTSISGIAIEALKKITAVGKDFGIETGFCGKGQTAFVSSGGPHMRFDGGIIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL98</accession>
    <name>F0LL98_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00772"/>
    <dbReference type="EnsemblBacteria" id="ADT83749">
        <property type="protein sequence ID" value="ADT83749"/>
        <property type="gene ID" value="TERMP_00772"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00772"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.774"/>
    <dbReference type="eggNOG" id="arCOG01403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_1_2"/>
    <dbReference type="OMA" id="FICERFN"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="110"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="330" mass="37440" checksum="EBF5736320BE299D" modified="2011-05-03" version="1">MNELYKKEHFDITHGHSIYSPIAVGVSNLSSGIRGVPSIITNHSFLGNSILNPTYILLLQTSLRKIDGFIAVSNAVKKDLENILRGSLRNRPIYVVPNGIDTNFWRPVEDKEEWKSKMGLDGGIVITTTSRLTKRKRVNVIPKLAKEIIEKYRIEDIKFVIIGDGPEKRRIKELIKAYHIQDKVLMVGKQPREKVREYLWASDIYLSPAIYEAFGIAALEALSCGVPVVANNHGGISEIVRHGVTGLISEDDMELLENVLYLLNNIELVEKMGKNARKIVKEEFTWEKIAKEIVEIYKKTIETFEERPFILYALHQMLKGGIKNAGVFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLD0</accession>
    <name>F0LLD0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467079.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00804"/>
    <dbReference type="EnsemblBacteria" id="ADT83781">
        <property type="protein sequence ID" value="ADT83781"/>
        <property type="gene ID" value="TERMP_00804"/>
    </dbReference>
    <dbReference type="GeneID" id="10041122"/>
    <dbReference type="KEGG" id="tba:TERMP_00804"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.806"/>
    <dbReference type="eggNOG" id="arCOG05844">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051622_0_0_2"/>
    <dbReference type="OMA" id="MADIAHH"/>
    <dbReference type="OrthoDB" id="52269at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="421" mass="48333" checksum="7AC6805627FFE3A3" modified="2011-05-03" version="1">MLIKEALASVDVIQSPYIRAVTYARIGATLALAKNPLYEQAFKKAFDAAEEIDNPIEILKALLAIAFYLGKAKMKSSKKMFRQLAEDIMILPKKTRDKLFRDLISYMLQLGEIDEAFYYSEYISNEKLKNEILVNILKEYLSTLVGEKIRIIYRIRKIELILDHINKEPYRSYAIAEIIKSYLKIGEYDRAILMIKELKSKYWLKQTVKEVLFYLKHKDLDKKYADRLLTVAIEISDNLGIDINEDLAVIFAINGDIAHSVEALSHVSDKEQKLIEIMKALMERRPGTVIPYLQTLDPKDSEIASKAVLNYLIDNPSPKYSSIARYISEKIESEEVIVKAVQYYLKIGQVVEAARMTSKLKSRKLRSLALGDIAHYLLKNNKIGDALDLVMHVEDPKLSSVLISEILVKVIEDELKKEHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLD7</accession>
    <name>F0LLD7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01992"/>
    <dbReference type="EnsemblBacteria" id="ADT84966">
        <property type="protein sequence ID" value="ADT84966"/>
        <property type="gene ID" value="TERMP_01992"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01992"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1989"/>
    <dbReference type="eggNOG" id="arCOG02697">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116585_0_0_2"/>
    <dbReference type="OMA" id="YNFDEVF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009482">
        <property type="entry name" value="DUF1102"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06510">
        <property type="entry name" value="DUF1102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="203" mass="21933" checksum="CE1BCB576E8A307A" modified="2011-05-03" version="1">MEMKEVKKLALGIFGLLVAFGLVLGAGANFSDYNASRSVHWAIVTDDTELIDLTPLQPYAYINEGGVLVVDFSANNPMWPGEGYGMGISPSSEYNFDEVFEVSNDLWENMTIIVRITSSDTHVEFYGHEGGVYAVDGGAEATASDSARDDVCFALGPGERKKIGIDLSANGDSPGDVWDETMTIKAYRLGTEPAELQGICEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLD9</accession>
    <name>F0LLD9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84968">
        <property type="protein sequence ID" value="ADT84968"/>
        <property type="gene ID" value="TERMP_01994"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01994"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1991"/>
    <dbReference type="eggNOG" id="arCOG12959">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3057324_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="53" mass="6046" checksum="0ABFD479387179FE" modified="2011-05-03" version="1">MMFWAFSSGGITTAVISVIIFAIGISLMAVPKIWSFADRMRQTYIIEDWSEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLI0</accession>
    <name>F0LLI0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="2 6">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purM</name>
        <name evidence="9" type="ordered locus">TERMP_02035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468305.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02035"/>
    <dbReference type="EnsemblBacteria" id="ADT85009">
        <property type="protein sequence ID" value="ADT85009"/>
        <property type="gene ID" value="TERMP_02035"/>
    </dbReference>
    <dbReference type="GeneID" id="10042350"/>
    <dbReference type="KEGG" id="tba:TERMP_02035"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2032"/>
    <dbReference type="eggNOG" id="arCOG00639">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047116_0_0_2"/>
    <dbReference type="OMA" id="EPLFMTD"/>
    <dbReference type="OrthoDB" id="62508at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="7">
        <location>
            <begin position="57"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="8">
        <location>
            <begin position="171"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT85009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="334" mass="36879" checksum="17C249F774CE3AF2" modified="2011-05-03" version="1">MLTYAQAGVDERKAQKALRSIISLARKTFRFRRGKIGEPVEDIGHYAALMDFGDFYLAMTTDGVGTKILVAEAVGKFDTIGIDMVAMNVNDLICVGAEPIALVDYLAVRDPNDKIFREIAKGLYEGAKQSGIAIVGGETAVMPDLINGFDLAGTAIGIVGKEKVITGNKIKPGDVVIGIESSGIHSNGLTLARKLLIPKYGLEYEFEGKTLWEHLLEPTRIYVKPILELLEKVEVKGLAHITGGGLLNLKRLTKYGFSLEMPPIRGIFKLIYENGVPLEEMFKVFNMGIGFVVIVSQGEKEETLQILNNYYLSYEIGKVIKKPKIKIENYKIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLJ4</accession>
    <name>F0LLJ4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02049"/>
    <dbReference type="EnsemblBacteria" id="ADT85023">
        <property type="protein sequence ID" value="ADT85023"/>
        <property type="gene ID" value="TERMP_02049"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02049"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2046"/>
    <dbReference type="eggNOG" id="arCOG03043">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_817899_0_0_2"/>
    <dbReference type="OMA" id="YEHFGMP"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="335" mass="39267" checksum="8B97203553C73DE4" modified="2011-05-03" version="1">MKEFEKALKRKDCEAVLEHLDDYLEEIEKEDELRELLKKLEDLALECEGELAYELAHEIAHIYAHLDEIEKGIEVYKKIAEKHKGDEEKYSEALYYLADAYEHFGMPDKAIDVYEKLLELERKRGDKKEEALTLAHMAVNYEELGDLDKAIELMEKARTLFEELGDEKNYLISLIDLAHFYYEKGEDKKAEELIKEVLKTPRDTDIEINARLIEAEVYAGREDYKGAFKSLSLALAKAEENEELFEFAFDTLTEFVKDLFNEKLYREVYENIDVLVNAFEEDKELKNFFTAIRELAKMKEGRENKFEEVYSKISNESLSEILEDLKSPTFLNIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLK7</accession>
    <name>F0LLK7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02062"/>
    <dbReference type="EnsemblBacteria" id="ADT85036">
        <property type="protein sequence ID" value="ADT85036"/>
        <property type="gene ID" value="TERMP_02062"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02062"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2059"/>
    <dbReference type="eggNOG" id="arCOG01040">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046932_2_3_2"/>
    <dbReference type="OMA" id="GVTIWFT"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="142" mass="16098" checksum="5A158E3732E70415" modified="2011-05-03" version="1">MEGFTIWLTGPSGAGKTVLAHALKKKLKEMGYKVEILDGDVIRKTLYPNLGFSKEAREMHNRIVIYMAKLLSRNGVIAIVSLISPYRAVREYARKEIGRFIEVYVYAPLEVRIQRDPKGLYKKAMRGEIKGLTGYDGVYDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLQ1</accession>
    <name>F0LLQ1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467126.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00851"/>
    <dbReference type="EnsemblBacteria" id="ADT83828">
        <property type="protein sequence ID" value="ADT83828"/>
        <property type="gene ID" value="TERMP_00851"/>
    </dbReference>
    <dbReference type="GeneID" id="10041169"/>
    <dbReference type="KEGG" id="tba:TERMP_00851"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.854"/>
    <dbReference type="eggNOG" id="arCOG03792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102063_2_0_2"/>
    <dbReference type="OMA" id="RESPVAN"/>
    <dbReference type="OrthoDB" id="101818at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005489">
        <property type="entry name" value="DUF257"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03192">
        <property type="entry name" value="DUF257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="212" mass="24133" checksum="F2094036EBAA6584" modified="2011-05-03" version="1">MKIMLGRIWDSLKFGETVLLEHSATTPTALGLCHLIKWAKGKEYDVLIDDILDSLYLYKMHMKLSGCGDEILDNVRVIKTGGRLEVGKVIERLSIKEPVIQEQEYRRVFGPLLEETKVVNPVVGFEKLLLLTNSKREIITTLNNILSFVGDERRIAFYFINVDVLESITPRVLPLLEEIATTVVRITKDGRSFRFAVVKSINNEIDGMEIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLS9</accession>
    <name>F0LLS9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MazG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="YPGVCPY"/>
    <dbReference type="OrthoDB" id="122764at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="96" mass="11292" checksum="BDE37390CEEF0399" modified="2011-05-03" version="1">MNIREFQQMIRDIYFHRDSQRGLERTFLWFVEEVGELSEALRKGKKEDIEEEFADVFAWLVSLANLAGVDLEKAALKKYPNKCPYCGKNPCECKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLU4</accession>
    <name>F0LLU4_THEBM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">TERMP_02069</name>
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        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
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        <lineage>
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            <taxon>Euryarchaeota</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
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        <text evidence="1">Belongs to the UPF0175 family.</text>
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    <dbReference type="EnsemblBacteria" id="ADT85043">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="44" mass="5010" checksum="FABCB2E511690EDC" modified="2011-05-03" version="1">MGKAAELLGITREELIEEFHKRGIPIRKLSKEDVIADVEALNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLV8</accession>
    <name>F0LLV8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02083"/>
    <dbReference type="EnsemblBacteria" id="ADT85057">
        <property type="protein sequence ID" value="ADT85057"/>
        <property type="gene ID" value="TERMP_02083"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02083"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2080"/>
    <dbReference type="eggNOG" id="arCOG02219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3163304_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="47" mass="5449" checksum="0EC4D72441EDA1A8" modified="2011-05-03" version="1">MKRNGELIEDADLLIAATAIAKGYTLWTRNIKHFERLEKFGLRLFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLX8</accession>
    <name>F0LLX8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02103"/>
    <dbReference type="EnsemblBacteria" id="ADT85077">
        <property type="protein sequence ID" value="ADT85077"/>
        <property type="gene ID" value="TERMP_02103"/>
    </dbReference>
    <dbReference type="GeneID" id="10042418"/>
    <dbReference type="KEGG" id="tba:TERMP_02103"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2100"/>
    <dbReference type="eggNOG" id="arCOG08623">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190409_0_0_2"/>
    <dbReference type="OrthoDB" id="125126at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="61" mass="7027" checksum="39F4697100C2DEB1" modified="2011-05-03" version="1">MGEVVITFRIPKEVEVKIKEEIERLKARANVDEALKKARGSLKTAKSWEELEAELYDELVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM06</accession>
    <name>F0LM06_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical NagD phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468401.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02131"/>
    <dbReference type="EnsemblBacteria" id="ADT85105">
        <property type="protein sequence ID" value="ADT85105"/>
        <property type="gene ID" value="TERMP_02131"/>
    </dbReference>
    <dbReference type="GeneID" id="10042446"/>
    <dbReference type="KEGG" id="tba:TERMP_02131"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2128"/>
    <dbReference type="eggNOG" id="arCOG04221">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_043473_1_2_2"/>
    <dbReference type="OMA" id="PPMHRET"/>
    <dbReference type="OrthoDB" id="50266at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
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        <property type="entry name" value="HAD_sf"/>
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    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="265" mass="29575" checksum="74176D889CCD7DFD" modified="2011-05-03" version="1">MLGIIFDMDGVIYRGNTPIEGAKEVIDYLKSRNVPFVFLTNNSTKNAKMYREKLLNLGIDVEEDWIITSGYATARYLQKHFRKGKVFVIGGKGLVEEIKNIGWEIMSVGEAKERWREIEYVVVGLDTKLTYEKLKYGTLAIRNGAKFIGTNPDTTYPGEEGILPGAGSILAALKASTDVEPLIIGKPNEPVFEVVKEKLTADEIWVVGDRLDTDIAFAKRIGAKAIMVLTGVNTLKDIEKSKIKPDLVLPSIKELLEYLKVHIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM57</accession>
    <name>F0LM57_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
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            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467202.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00928"/>
    <dbReference type="EnsemblBacteria" id="ADT83904">
        <property type="protein sequence ID" value="ADT83904"/>
        <property type="gene ID" value="TERMP_00928"/>
    </dbReference>
    <dbReference type="GeneID" id="10041245"/>
    <dbReference type="KEGG" id="tba:TERMP_00928"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.929"/>
    <dbReference type="eggNOG" id="arCOG00033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022610_0_1_2"/>
    <dbReference type="OMA" id="FNPRMKG"/>
    <dbReference type="OrthoDB" id="55502at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040601">
        <property type="entry name" value="Trm5_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18093">
        <property type="entry name" value="Trm5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="3">
        <location>
            <begin position="90"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="336" mass="39190" checksum="3595E0AB8D398022" modified="2011-05-03" version="1">MPAVRVQKHEAEKVKNLLKKLGLYDGKRRPKREENFVLLPVISSPKLMELGFEVIDVELPFRPERQIYKNLESVLAEKLTKEELAYLRRYDIIGDIAVVQIPKELEHRQRDIIEALLIVHPFVKVIAKRGVHEGKFRVRKYEIIWGEKRLTTVHKENGVKIKVDLSRVFFNPRMKGERYRLAQLVQDGERILLMFAGALPYALVIARFKNVEITAIELNEDAVKLGLENIELNKDKLRGKIEVIHGDVFEVVPKLGTFERVISPTPKGIDALSLALSKAEKWVHYYDFVHEDRFNEFKKRIEKECQKLGKQCEVRIKKIADYKPHVYKVCADVMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM63</accession>
    <name>F0LM63_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467208.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00934"/>
    <dbReference type="EnsemblBacteria" id="ADT83910">
        <property type="protein sequence ID" value="ADT83910"/>
        <property type="gene ID" value="TERMP_00934"/>
    </dbReference>
    <dbReference type="GeneID" id="10041251"/>
    <dbReference type="KEGG" id="tba:TERMP_00934"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.935"/>
    <dbReference type="eggNOG" id="arCOG00497">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_4_0_2"/>
    <dbReference type="OMA" id="IGPKTVY"/>
    <dbReference type="OrthoDB" id="76909at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="7"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="211" mass="24001" checksum="4A54C1B2F0AEA8EF" modified="2011-05-03" version="1">MKIVWYGHACFLIETRGVRILIDPYPDVDDDKIGEVDYILVTHEHSDHYGKTPLLARLRKAKVIGPKTVYLMAISDGITDVQAIEEGEELQLKNEIKIKGTYAEHPSSQYPLGYLIFGDKRVWHTGDTYYTPLFNKLRGMVDILLVPISGRSTASEREAADIIEAVRPRIVIPMHYGVYGSGSVEKLQQELRKRRVWVLVKPLNIGEAFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM70</accession>
    <name>F0LM70_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PhoI-like type II restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467215.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00941"/>
    <dbReference type="EnsemblBacteria" id="ADT83917">
        <property type="protein sequence ID" value="ADT83917"/>
        <property type="gene ID" value="TERMP_00941"/>
    </dbReference>
    <dbReference type="GeneID" id="10041258"/>
    <dbReference type="KEGG" id="tba:TERMP_00941"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.944"/>
    <dbReference type="eggNOG" id="arCOG07157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_961785_0_0_2"/>
    <dbReference type="OMA" id="WYIVVHA"/>
    <dbReference type="OrthoDB" id="51968at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="297" mass="33819" checksum="15DFC22399A14DBF" modified="2011-05-03" version="1">MGWNELGSYELESFQVFFPASLEIQEELLKAGFKVPYDKEKGFATPIPVVAAFKTGRKLRKDKLLKGRKIKENGNFAEIGPERALLKLLINEKGFLKLEFEVKNYHLEDLGFVKVPPRIWSTWASFSLPIDAFGDITEKLGGFANERPKGMYFASKSNGKEIEVYSYRGRKAKNLGIPVFGYNLSLESFELVKEYLNEKTEQNRVNKEVLPYLKLGLKKRTETKAGLKVGIVWREGKAGRITLKLSTTYPKIKIIGLYGELEGKSRGELSNEKDHFIIVHSNDFYWALLNAKSAFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM93</accession>
    <name>F0LM93_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">TERMP_00964</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467238.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00964"/>
    <dbReference type="EnsemblBacteria" id="ADT83940">
        <property type="protein sequence ID" value="ADT83940"/>
        <property type="gene ID" value="TERMP_00964"/>
    </dbReference>
    <dbReference type="GeneID" id="10041281"/>
    <dbReference type="KEGG" id="tba:TERMP_00964"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.967"/>
    <dbReference type="eggNOG" id="arCOG00422">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029960_1_1_2"/>
    <dbReference type="OMA" id="HAIYYPP"/>
    <dbReference type="OrthoDB" id="30068at2157"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="14">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="15">
        <location>
            <begin position="176"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="12">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADT83940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="328" mass="38865" checksum="24EB87E61B202DE0" modified="2011-05-03" version="1">MRELRYNPLTGQWIMVSAVRKKRPWRPKNFCPFCPGGEETGFGWEVLLLPNKFPMLDFKAEKPQNEDFYKKARAIGQCSVIVETPEHNLKDLDELSLEQMVKVVELWKNVTMELKDNPHVAYLAIFRNKGEEIGVSLTHPHGQLYALPFIPLKARLKIENSRKHYRRFGECLFCRILREEMQSERAIYENGSFMLFMPFFANWPFEIHIYPKKHVQWLTQLNSEEIEDLADILRVATATLNALFERQMPYVMNVYQAPFKGHYDFYHLHIEFYPMLRDRNKLKYAAGIELGTWEFTYDGVQEENAQKLREACKKILERVEAKGRCFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMB6</accession>
    <name>F0LMB6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT85139">
        <property type="protein sequence ID" value="ADT85139"/>
        <property type="gene ID" value="TERMP_02165"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02165"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2160"/>
    <dbReference type="HOGENOM" id="CLU_3094309_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="51" mass="6080" checksum="2F65C0F37003E9C1" modified="2011-05-03" version="1">MAIHFWAITYINLSPKKLGKLLFLNERLYMEISARIRKFPKLFGLEKPTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMH1</accession>
    <name>F0LMH1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polyferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467248.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00974"/>
    <dbReference type="EnsemblBacteria" id="ADT83950">
        <property type="protein sequence ID" value="ADT83950"/>
        <property type="gene ID" value="TERMP_00974"/>
    </dbReference>
    <dbReference type="GeneID" id="10041291"/>
    <dbReference type="KEGG" id="tba:TERMP_00974"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.977"/>
    <dbReference type="eggNOG" id="arCOG05744">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1582974_0_0_2"/>
    <dbReference type="OMA" id="SLCVQIC"/>
    <dbReference type="OrthoDB" id="78493at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="168" mass="18754" checksum="D009C890F918171D" modified="2011-05-03" version="1">MSEIPHYLREGFITLEELKKAIELPSEERLRKRPVAIPECPQEIPCTPCKEICPTNAVLMENPNATPIVDYEKCIGCSLCVQICPGLAFFMIHYVGDKARVTMPHELLPVPKVGEEVILLNRVGEEVGRGKVITVVPRGKSKGDTPIITVEMPIELAWDVRAVKVVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMI5</accession>
    <name>F0LMI5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467262.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00988"/>
    <dbReference type="EnsemblBacteria" id="ADT83964">
        <property type="protein sequence ID" value="ADT83964"/>
        <property type="gene ID" value="TERMP_00988"/>
    </dbReference>
    <dbReference type="GeneID" id="10041305"/>
    <dbReference type="KEGG" id="tba:TERMP_00988"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.991"/>
    <dbReference type="eggNOG" id="arCOG03807">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2366334_0_0_2"/>
    <dbReference type="OMA" id="KMDGFEP"/>
    <dbReference type="OrthoDB" id="111483at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014418">
        <property type="entry name" value="UCP004604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036216">
        <property type="entry name" value="UCP004604_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08967">
        <property type="entry name" value="DUF1884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004604">
        <property type="entry name" value="UCP004604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111057">
        <property type="entry name" value="SSF111057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="94" mass="10551" checksum="8222BB39AF642C37" modified="2011-05-03" version="1">MRGDLIRILSAVEEKANELKMDGFEPDIVLFGKEAYEFLKAQVDEEFGEDERITEVSGLKVRVLEELGRDAVVIDSKMLGIGLGGARRIRIIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LML1</accession>
    <name>F0LML1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitro_FeMo-Co domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467288.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01014"/>
    <dbReference type="EnsemblBacteria" id="ADT83990">
        <property type="protein sequence ID" value="ADT83990"/>
        <property type="gene ID" value="TERMP_01014"/>
    </dbReference>
    <dbReference type="GeneID" id="10041331"/>
    <dbReference type="KEGG" id="tba:TERMP_01014"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1017"/>
    <dbReference type="eggNOG" id="arCOG02734">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104194_0_1_2"/>
    <dbReference type="OMA" id="QFCIDQG"/>
    <dbReference type="OrthoDB" id="118295at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00851">
        <property type="entry name" value="MTH1175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033913">
        <property type="entry name" value="MTH1175_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="2">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="144" mass="14972" checksum="8E6EAC7714AB64D8" modified="2011-05-03" version="1">MRIVVATIKGGLNDFVSQAFGRAPTFTIVDVNEEGNIINVQAVQNPAYSAPRAAGIQAAQFCINEGADVVIAGQFGPNSSQVLQAAGIKFVSAPPTMTVEQAVQAYLRGELTQPILGAEGSGIGPRRGMGRGRGKGMGRGVDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LML7</accession>
    <name>F0LML7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Geranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="9">GGGP synthase</shortName>
            <shortName evidence="9">GGGPS</shortName>
            <ecNumber evidence="9">2.5.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(S)-3-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoglycerol geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TERMP_01020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23404"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GGGP/HepGP synthase family. Group II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.41" evidence="9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467294.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01020"/>
    <dbReference type="EnsemblBacteria" id="ADT83996">
        <property type="protein sequence ID" value="ADT83996"/>
        <property type="gene ID" value="TERMP_01020"/>
    </dbReference>
    <dbReference type="GeneID" id="26136470"/>
    <dbReference type="KEGG" id="tba:TERMP_01020"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1023"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PcrB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GGGP/HepGP_synthase_sf"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01884">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GGGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01768">
        <property type="entry name" value="GGGP-family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="9">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="9">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="9">
        <location>
            <begin position="228"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="253" mass="27278" checksum="67EA926C6A3992B7" modified="2011-05-03" version="1">MKLRFGRVESYIHEKLEKEKLHFVLLDPDDVSPEEASKIAQMCEEVGVDAVMVGGSTGAEGEVLDEVVKAIKESSSLPVILFPGSHGGITKYADAIFFMSLLNSRNPFFITGAQALGAFTVKRYRIEPIPMAYLIIEPGETVGWVGDAKPIPRHKPKIAAAYALAGQYLGMRLVYLEAGSGAPEHVPNDMIRAVKSVIDVPLIVGGGIRTYEDAREVAQSGADIIVTGTAIEKAGSLEEARKRLESLIKGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMY6</accession>
    <name>F0LMY6_THEBM</name>
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        <submittedName>
            <fullName evidence="8">Na(+) H(+) antiporter subunit A Na(+) H(+) antiporter subunit B</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ordered locus">TERMP_01139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="ADT84115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
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    <dbReference type="EnsemblBacteria" id="ADT84115">
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        <property type="gene ID" value="TERMP_01139"/>
    </dbReference>
    <dbReference type="GeneID" id="10041456"/>
    <dbReference type="KEGG" id="tba:TERMP_01139"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1142"/>
    <dbReference type="eggNOG" id="arCOG01537">
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    </dbReference>
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    <dbReference type="OrthoDB" id="28394at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:ATP synthesis coupled electron transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
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        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
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            <end position="100"/>
        </location>
    </feature>
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        <location>
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            <end position="130"/>
        </location>
    </feature>
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            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="351"/>
        </location>
    </feature>
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        <location>
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            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="74"/>
            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="132"/>
            <end position="437"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="520" mass="55974" checksum="A82035D278474290" modified="2011-05-03" version="1">MNVAGLTPIIPIVFAFALPLFSILIKGNRKIVQTYALIGTGLTLISSFKLFQLAYSSSTPLVYTFGKWIAPIGIVYEVDRLSALIALVTAGLMFLIAIYSYRYLEHEEGLEWYYTLYLGLEAGLLGVLLTGDAFNLFVMIEVTSIAAYALVMFYRDRGDSVTAGLKYALIGAVGTTMYFLALGVFYGAFGTVNFADLSAKVHSLSFPVTGSPVGNIILASGVALALATWAFLIKAAIVPNHFWLPEAHPAAPSPISAVLSGLVVNVGVYALIRFLYTVYGGSLAPELAHIIGTLSTIVIVLGAVSALFGALMMNIQRDVKRLIAYSTIMHMGYLFMAVGLGTSLGLQAALFHLVNHAIAKALLFLAAGVFIHAVGSRNIEDLAGLGRRMPIATFSLAIATLSLVGIPPLNVFFSKLLLFNAFLDRSLVLALVLVLSSATALIAYMRVFYVVWLRKPKENLEIKEPTSMSLVCLLLALVVIVIGLMAPIITDKLITPAATQTMDYNSYVNAILNLASRVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN12</accession>
    <name>F0LN12_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiamine biosynthesis ThiI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01165"/>
    <dbReference type="EnsemblBacteria" id="ADT84141">
        <property type="protein sequence ID" value="ADT84141"/>
        <property type="gene ID" value="TERMP_01165"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01165"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1168"/>
    <dbReference type="eggNOG" id="arCOG00038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037952_0_0_2"/>
    <dbReference type="OMA" id="AIHLMAS"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiI" evidence="3">
        <location>
            <begin position="3"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="198" mass="22602" checksum="69ED173DB23B2936" modified="2011-05-03" version="1">MVKAVALLSSGIDSPVAIYLMLKKGLEVIPIHFKQDEGKYKKVQKIWKQLKELYPERLKELVVVDVYEYQAPVFEKIMEMKKHKWICVFCKFTMYRKATEIARENGALAIITGDSLGQVASQTLDNLFIISLATDLPILRPLIGLDKEEVIKIAKKIGTFDISIEPEEGCPFVPKHPIIRGSLGEFRRIYKEIFQASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN33</accession>
    <name>F0LN33_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467460.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01186"/>
    <dbReference type="EnsemblBacteria" id="ADT84162">
        <property type="protein sequence ID" value="ADT84162"/>
        <property type="gene ID" value="TERMP_01186"/>
    </dbReference>
    <dbReference type="GeneID" id="26136648"/>
    <dbReference type="KEGG" id="tba:TERMP_01186"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1189"/>
    <dbReference type="eggNOG" id="arCOG05819">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1324067_0_0_2"/>
    <dbReference type="OMA" id="MKFKGKA"/>
    <dbReference type="OrthoDB" id="89904at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="204" mass="23544" checksum="98CB54164349E33C" modified="2011-05-03" version="1">MKFKGKAFGDMVRIEFEILRLSELKIDDLRDFDVDNLKIELRSTSSGLKIIGIWEGEIEKAGEGIKKALEESYKLKERILRKMKAKVDSIRATMKRLGFKEEIVGYGSMIRFTKKVGNYEIVVLTSSKDDIVRVEVYGNDKKIIGPEVESLFEDVDIEELEVYDLEEDGREERLVINLELPRGEEKPEAKIIEAIRLIENLLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN49</accession>
    <name>F0LN49_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
            <plasmid evidence="2 3">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747410.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02215"/>
    <dbReference type="EnsemblBacteria" id="ADT85188">
        <property type="protein sequence ID" value="ADT85188"/>
        <property type="gene ID" value="TERMP_02215"/>
    </dbReference>
    <dbReference type="GeneID" id="10549039"/>
    <dbReference type="KEGG" id="tba:TERMP_02215"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2209"/>
    <dbReference type="eggNOG" id="arCOG03167">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044680_0_0_2"/>
    <dbReference type="OMA" id="KTTMLAQ"/>
    <dbReference type="OrthoDB" id="21850at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="55"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="460" mass="51939" checksum="F7D93F24606C53EB" modified="2011-05-03" version="1">MDEKLVESIVRRTIDTAEARLRKYAFTPAGEKRPERKPLAKLSEEIESFLRTRENKLLVLYGLRGVGKTTMLAQTYFKLLPQISRERLVYVPLDKLRSLGISLSDFIQAYERLLGERVEEFSQPTFLFIDEAHYDENFGITVKDLHDSANNLMIVVTGSSSLPLKLDPDLTRRAKKLRVPPLTFTEYLLLKKGIRIPEELSIALKHALLNCDFSGIEEKLEGVLLKFTEKDVEDYLIQGSLPIYLTSTSPLEDAYEIVRKIVEVDLVREGLSETTREKALGLLLLLASGESLAYDDLSSTLGLAKGTIEKLIEKLEDLEVIFPVRAYGSLGKVARKTPKYKFLAPMLRSAVLYEFGLFERDSKTLGMLLEDAVALYLHLLAKEKKLGLHYDAQKGGADFILKGHSIGIVIEVGWGKKDLRQVIKTMKKTGLTCGVVIYNGPLKKKGDVWFVPRELFLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN59</accession>
    <name>F0LN59_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Programmed cell death antitoxin YdcD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
            <plasmid evidence="2 3">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747420.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT85198">
        <property type="protein sequence ID" value="ADT85198"/>
        <property type="gene ID" value="TERMP_02225"/>
    </dbReference>
    <dbReference type="GeneID" id="10549049"/>
    <dbReference type="KEGG" id="tba:TERMP_02225"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2219"/>
    <dbReference type="eggNOG" id="arCOG01011">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2140283_0_0_2"/>
    <dbReference type="OMA" id="GQIMMEK"/>
    <dbReference type="OrthoDB" id="116798at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016748">
        <property type="entry name" value="Tscrpt_reg_CopG_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019108">
        <property type="entry name" value="Txn_reg_CopG_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="107" mass="12499" checksum="A06A82FB69EB4824" modified="2011-05-03" version="1">MAQVIESPVSVRLPKYIIKKIDELVKEGEFKSRSDFIKYAVTLTLGQIMMEKAREKAKTITPEEAKARSRQALQKLFTEEIEDEWSEIKDILEDADRKWKELKGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN65</accession>
    <name>F0LN65_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747426.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02231"/>
    <dbReference type="EnsemblBacteria" id="ADT85204">
        <property type="protein sequence ID" value="ADT85204"/>
        <property type="gene ID" value="TERMP_02231"/>
    </dbReference>
    <dbReference type="GeneID" id="10549055"/>
    <dbReference type="KEGG" id="tba:TERMP_02231"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2225"/>
    <dbReference type="HOGENOM" id="CLU_902005_0_0_2"/>
    <dbReference type="OrthoDB" id="133176at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="308" mass="36211" checksum="5A8EB28B44B21D31" modified="2011-05-03" version="1">MVKLIPILYGNKRYPYGIKPKIKEIPAHFDSKTKIPCNFDYSLHTEYSYYPRKFTSPACKGLIGIKRADKRGVPKLWFDEDWVGDFIVFIFRLVGEKRPPKIIEIHPPFNDYCKNLSHFVDLYEKFEREILNKYPDVQIFIENRYGTQYHGGNFILSTTYDLKKLTKLIETRELKLRIALDIPQLFSAHNMEIGRFSKKRISQIFKELYPIRGYIMSIHLWGKCLGKNKRPTSHVGTLDSYFGGLKCKELSKGNPQEQVRELKVHFLRELHDLLNDGLVRYFVPEVNSNSIHLHSIVKDLISFGFEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN69</accession>
    <name>F0LN69_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT85208">
        <property type="protein sequence ID" value="ADT85208"/>
        <property type="gene ID" value="TERMP_02235"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02235"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2229"/>
    <dbReference type="eggNOG" id="arCOG14122">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3113230_0_0_2"/>
    <dbReference type="OMA" id="MIMEPIK"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="52" mass="6002" checksum="6602FE72A3FDE176" modified="2011-05-03" version="1">MIMEPIKIIAGFLLWVVLLLFLLALGRSFWKALVELLADVCEEVEKRRKDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN80</accession>
    <name>F0LN80_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747441.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02246"/>
    <dbReference type="EnsemblBacteria" id="ADT85219">
        <property type="protein sequence ID" value="ADT85219"/>
        <property type="gene ID" value="TERMP_02246"/>
    </dbReference>
    <dbReference type="GeneID" id="10549070"/>
    <dbReference type="KEGG" id="tba:TERMP_02246"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2240"/>
    <dbReference type="HOGENOM" id="CLU_2447816_0_0_2"/>
    <dbReference type="OrthoDB" id="120603at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="89" mass="10482" checksum="6DA7A16DF248FC7B" modified="2011-05-03" version="1">MVVVRVLKPSEIKASYSNWAEILDETGWWFNNGEIVVVKQENKLEELKTILHEVFEFYLEKYFGLSHEVAHQLALNLEEFAEKSLKKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN94</accession>
    <name>F0LN94_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747455.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02260"/>
    <dbReference type="EnsemblBacteria" id="ADT85233">
        <property type="protein sequence ID" value="ADT85233"/>
        <property type="gene ID" value="TERMP_02260"/>
    </dbReference>
    <dbReference type="GeneID" id="10549084"/>
    <dbReference type="KEGG" id="tba:TERMP_02260"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2254"/>
    <dbReference type="HOGENOM" id="CLU_2103629_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="115" mass="14101" checksum="A2FBAA233B8B1048" modified="2011-05-03" version="1">MFVKSWFASYERLQISLRTKYGLMRLKKEGKLYHKPSIVHYYAAWLYDKDFSELTKEELESARKQLVKIVKKYWDNPAVKKTKIGELLRQNELREMYIRFPKAPDSYFTWRRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGU9</accession>
    <name>F0LGU9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466286.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT82988">
        <property type="protein sequence ID" value="ADT82988"/>
        <property type="gene ID" value="TERMP_00010"/>
    </dbReference>
    <dbReference type="GeneID" id="10040329"/>
    <dbReference type="KEGG" id="tba:TERMP_00010"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.9"/>
    <dbReference type="eggNOG" id="arCOG04084">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_741068_0_0_2"/>
    <dbReference type="OrthoDB" id="26182at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT82988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="373" mass="43654" checksum="963CFAB89713BD88" modified="2011-05-03" version="1">MDPKLVEMHRKLFSNKLQKRLILDEREGVVFNPGIYRSEDGKYYLYARTSTHHVNYTSWIRLYESEDGINFRKTKEFFLYPPYTIEEYIYGFEDDRCSKINEWWVHTHSTLLANDTESPSRKNYSDYIGVSLGKKADEAYFVGIVDISDDKNSALVGDKPWLIHRPVTWSKPPCIWYGDFGEGFKQAQALYPKAKENKLPYERLVRITPPKNNRILLAPLDEWEVYKIGLGAQPIYIGNSRYLFTVHVRSIPYQYWVTVGILKVKDEPKIEKLLPIPLCIPDTPWEIIGDVPKVCFICGVTLADGKVEGWYGAADTRIMKFEIDLDYILSVIEEYGITEEKINENIEKYVKENRDKLINNELIDQEWLHTILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGV9</accession>
    <name>F0LGV9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxygluconate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT82998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00020"/>
    <dbReference type="EnsemblBacteria" id="ADT82998">
        <property type="protein sequence ID" value="ADT82998"/>
        <property type="gene ID" value="TERMP_00020"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00020"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.19"/>
    <dbReference type="eggNOG" id="arCOG00014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_0_1_2"/>
    <dbReference type="OMA" id="MAMFYAN"/>
    <dbReference type="OrthoDB" id="36944at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT82998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="319" mass="36124" checksum="B0E5D866D21B702D" modified="2011-05-03" version="1">MPSAVSFGETMIRFSTKNFERIEQAREFEVSIGGAESNFAIAFARLGGRSAWISKLTNNPLGRLIVNRIREHGVDVSNVIWTKEYRVGLYFIEFGRKPRGIEVLYDRKNSAFANIQPHEVNWDVLAEYDVFHTTGITVSLSESCRKSVKMGITKAKEFGTKVSFDVNYRAKLWSPEEAFKALDAILKEVDILIVTKEDAKSVLLAEGSYEDIARELYQRYGPEVLVLTLGSEGAMAIKDGRIYRVKPYPIEVVDRIGAGDAFDAGFIYRYLEKQDVKEALEWGIAMAALAHTIPGDPVYIVRDEVKRLIKGREYCEIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGW2</accession>
    <name>F0LGW2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00023"/>
    <dbReference type="EnsemblBacteria" id="ADT83001">
        <property type="protein sequence ID" value="ADT83001"/>
        <property type="gene ID" value="TERMP_00023"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00023"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.22"/>
    <dbReference type="eggNOG" id="arCOG00499">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044538_3_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07736">
        <property type="entry name" value="PhnP-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035682">
        <property type="entry name" value="PhnP_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="48"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="259" mass="28941" checksum="0EFFFB978C8BB574" modified="2011-05-03" version="1">MTRDGQEELGVILYFIGTAASEGIPNPLCKCSTCQEARKFAFAQRKPPTLAVILKKGGIILFDVGSDIGEHLPGVSIRTVFLTHWHNDHTYGLYKLRWVAKKLSLYAPREGADATILNEPRNLEIQFIKAGDTIKLPPLKITALKLNHFPETLGYLLESKKKKVAILYDTKGLPEETYELLKKKKPKVALVDATYPPGVEMPTHNNVDEAAVLGLSVAEKVYLTHIAHHNLPFTKLLEYVIEKYGEKVNVAYDGMVVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGW8</accession>
    <name>F0LGW8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="tba:TERMP_01200"/>
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    </dbReference>
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        <property type="entry name" value="Asn-tRNA-ligase"/>
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        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
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    </dbReference>
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        <property type="entry name" value="TRNASYNTHASP"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="6">
        <location>
            <begin position="131"/>
            <end position="422"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="430" mass="50003" checksum="61843C96B0CB44E1" modified="2011-05-03" version="1">MIEKIYCAQVKPEMEGKRVRLAGWVYRKREIKDKVFIVLRDSSGIIQTVFKEEISKEAYETAKKTGIESSVIIEGTVKQDKRAPGGVEIQADKIEVIQNVEFFPITKDASPEFLLDVRHLHLRSPKVAAIMKVKATMIQAAREWLLQDGWYEVFPPILVTGAVEGGATLFKLKYFDKTAYLSQSAQLYLEAAIFGLEKVWSLTPSFRAEKSRTRRHLTEFWHLELEAAWMDLWDIMKVEEELVSYMVQRTLELRRKEIEMYRKDFTTLKNTEPPFPRISYDEAIDILQSKGVNIEWGEDMGADEERVLTEEFDRPFFVYGYPKHIKAFYMKEDPSDPRKVLAADMLAPEGYGEIIGGSEREDDYDKLVQRILEEGMDPKDYEWYLDLRKYGSVPHSGFGLGVERVVAWILNLDHVRWATLFPRTPTRLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH01</accession>
    <name>F0LH01_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC2_membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT84209">
        <property type="protein sequence ID" value="ADT84209"/>
        <property type="gene ID" value="TERMP_01233"/>
    </dbReference>
    <dbReference type="GeneID" id="10041550"/>
    <dbReference type="KEGG" id="tba:TERMP_01233"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1234"/>
    <dbReference type="eggNOG" id="arCOG01465">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1105252_0_0_2"/>
    <dbReference type="OrthoDB" id="58769at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ABC_2_trans"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="13"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="251" mass="28755" checksum="26F466420D11EE4F" modified="2011-05-03" version="1">MRILAIARKEAKIQLRYRIVWLNFALTPFFIISPWILTAKSFSVEFGEAVLIGSLMWYWLNQYFFGVQEAFEEEREEGTLVSIALSPISLLEFLIGKGLWMLVECVYITVVTMLIFWMLGISQALSLKMLLLYVVSGLYMFAFSILWGALILWFRRIGGINFIVQEVLGLTSGITADVSAYPKFIRFAAYAVPLTYTIKIGRMIFKGASLDYIVKDLGILTAVTIIYFIIGALMLKKAEQKLRIYGEWEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH09</accession>
    <name>F0LH09_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01241"/>
    <dbReference type="EnsemblBacteria" id="ADT84217">
        <property type="protein sequence ID" value="ADT84217"/>
        <property type="gene ID" value="TERMP_01241"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01241"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1243"/>
    <dbReference type="eggNOG" id="arCOG00135">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014185_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="274" mass="29636" checksum="3EB5B6E190F7F6BD" modified="2011-05-03" version="1">MTLEESELQKLNAKVQTVGEVTSLLAFPVVGYLAYLFGVKLMLLDAVFLLIGALLLAPYINVVVRRREIAENENKSTQPTISPKVVFAGIVLILLFNFAIAPARIFVFNALKSLTRKEVIYGLLRSTGTLGSLAGVVGITLFAHKRKIGISKPLIVGMLFESFAVLLLGLPSLVSLFSGILLLNFGGGILNVSFDSLFQRIIPLKKLGTYRGIFDALATLIIPLSQLTFALLIEHGVDISMLAAGMFGLGVLSTAGFFILMCGIKKRGFTKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH20</accession>
    <name>F0LH20_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467526.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01252"/>
    <dbReference type="EnsemblBacteria" id="ADT84228">
        <property type="protein sequence ID" value="ADT84228"/>
        <property type="gene ID" value="TERMP_01252"/>
    </dbReference>
    <dbReference type="GeneID" id="10041569"/>
    <dbReference type="KEGG" id="tba:TERMP_01252"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1254"/>
    <dbReference type="eggNOG" id="arCOG03792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102063_2_0_2"/>
    <dbReference type="OMA" id="INTEMEG"/>
    <dbReference type="OrthoDB" id="107983at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005489">
        <property type="entry name" value="DUF257"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03192">
        <property type="entry name" value="DUF257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="224" mass="25266" checksum="8E94EA91AE85421C" modified="2011-05-03" version="1">MDNGVENLIRLWESLAPGESILAEYDSLVLPYKGFHYLISWAEKRGHSIMIIDVLDTLYLYKTQLKLAGVDTGIIDKASVVKIGGRLKVGNVLKRLPANDIPKLLKDFEGFYSEYLRKVQNHSGIVIVLGLSKLLLLAESKFEGLMVIDLLIKYTGTSGRIAFYFVNVDVLENSSRYLIPLLEELATTVIRVERARKEEDIEPYVYVTVAKAINAELEGFKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH44</accession>
    <name>F0LH44_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-formyltetrahydrofolate cyclo-ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467550.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01277"/>
    <dbReference type="EnsemblBacteria" id="ADT84252">
        <property type="protein sequence ID" value="ADT84252"/>
        <property type="gene ID" value="TERMP_01277"/>
    </dbReference>
    <dbReference type="GeneID" id="10042560"/>
    <dbReference type="KEGG" id="tba:TERMP_01277"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1279"/>
    <dbReference type="eggNOG" id="arCOG00474">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031500_2_0_2"/>
    <dbReference type="OMA" id="KTVYMAV"/>
    <dbReference type="OrthoDB" id="88805at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017">
        <property type="entry name" value="PTHR13017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="248" mass="28052" checksum="791AD48E2C6D7F74" modified="2011-05-03" version="1">MDIDGIRAEIREKIWRLLEETGEAMPPKPIRGRIPNFRGAEIAAKRLSSLEEWKKAEVIKINPDSPQRPVRVQALKEGKLLIMPTPRIKRGFLLINPSLIPKSYYSFASTIRGAFKFGKLLPTLRDIEKEIPKIDLVVEGSVAVDRNCNRLGKGEGYGDIEWGILSLLGKVDKNTPIATTVSELQIVDNIPKKPHDLPLNIIVTPKRVIRCNRCDKPFGIIPESLKKEKINEIPLLDELIRLGYVKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH51</accession>
    <name>F0LH51_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00035"/>
    <dbReference type="EnsemblBacteria" id="ADT83013">
        <property type="protein sequence ID" value="ADT83013"/>
        <property type="gene ID" value="TERMP_00035"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00035"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.34"/>
    <dbReference type="eggNOG" id="arCOG05766">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115258_0_0_2"/>
    <dbReference type="OMA" id="ADMISHF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="177" mass="20255" checksum="91F964ED455159A2" modified="2011-05-03" version="1">MRTDHIYRSGVALIGLFIPDVFQRKLNPPEKLMPFLSPLYNDRIIAILAVFIAVHVSLVNVPFTTIDLFHKEWRDADMISHFLGGLTVWIIVAGILNELSRKNSIDQKKLVIYSFLILLGISIGWEIAEKLSESEISFIHETLSNKFRDILMNTLGALSGLYLVKTRRYPFELPNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH71</accession>
    <name>F0LH71_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466331.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00055"/>
    <dbReference type="EnsemblBacteria" id="ADT83033">
        <property type="protein sequence ID" value="ADT83033"/>
        <property type="gene ID" value="TERMP_00055"/>
    </dbReference>
    <dbReference type="GeneID" id="10040374"/>
    <dbReference type="KEGG" id="tba:TERMP_00055"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.55"/>
    <dbReference type="eggNOG" id="arCOG05728">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_715000_0_0_2"/>
    <dbReference type="OMA" id="AFYTRDI"/>
    <dbReference type="OrthoDB" id="62172at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="387" mass="41459" checksum="18AFDAAD05CF6128" modified="2011-05-03" version="1">MKKQGLGIALLIASAFTGTLAFRLAVPAVAFYTRDILKASMVNISVISASFILARSLSALFSGLLLEKRKGLVYLGALAMTGNALAVNLYPFTSSWIHVVGIKLMNGFLNGIAWPIAQFVIAVSSPKEIRSRVTALYFIFGNFAGLLGNYTYALTQEFGLKGQMYLASLFFFLTALCMLLSYWLLYEKIVPKREKDTKEGEAPVDAKKILILSALISFLAAFTSGEITYVYVAETLNLDRGTATTLIGLIGFIATLLAYIPSKFADLGNERKVLITVSILAGVSPILAAIKNPITVFLGILMAIFAAQTFRPISRSLLASAKRASATIGGINAVRNISTTAGQLVFGLAYSLGEVAILGIVLKAALLIFAPVSLLLFGIAVMLNGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHA3</accession>
    <name>F0LHA3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn finger containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466363.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00087"/>
    <dbReference type="EnsemblBacteria" id="ADT83065">
        <property type="protein sequence ID" value="ADT83065"/>
        <property type="gene ID" value="TERMP_00087"/>
    </dbReference>
    <dbReference type="GeneID" id="10040406"/>
    <dbReference type="KEGG" id="tba:TERMP_00087"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.87"/>
    <dbReference type="eggNOG" id="arCOG04265">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107446_0_0_2"/>
    <dbReference type="OMA" id="HSAIIGD"/>
    <dbReference type="OrthoDB" id="109705at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004470">
        <property type="entry name" value="Znf_ZPR1-type_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="PTHR10876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="zf-ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00340">
        <property type="entry name" value="zpr1_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zpr1" evidence="5">
        <location>
            <begin position="14"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="209" mass="23712" checksum="B92D2E6CD9DA9114" modified="2011-05-03" version="1">MNEKTANIQEIRLGNCPICGGKDTLKAIQYIHDIPYFGKVMESTIICEKCGYRSADVMILEEKEPKLYTVKVEDEKDLFTRVVRSKSGTIELEELGIKIEPGPASQGFVSNVEGVLERVKETLLMARNFKEQENDKEAVNRIDELLEYIEDVKEGRRSLTVKIMDPFGNSALIGEKVKSRLLTKEEIKKLSTGPYVVIEPEELEKENAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHB3</accession>
    <name>F0LHB3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps3</name>
        <name evidence="9" type="ordered locus">TERMP_00097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds the lower part of the 30S subunit head.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466373.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00097"/>
    <dbReference type="EnsemblBacteria" id="ADT83075">
        <property type="protein sequence ID" value="ADT83075"/>
        <property type="gene ID" value="TERMP_00097"/>
    </dbReference>
    <dbReference type="GeneID" id="26135413"/>
    <dbReference type="KEGG" id="tba:TERMP_00097"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.98"/>
    <dbReference type="eggNOG" id="arCOG04097">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_1_1_2"/>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="OrthoDB" id="60366at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_A">
        <property type="entry name" value="Ribosomal_S3_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027488">
        <property type="entry name" value="Ribosomal_S3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_S3_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="8">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="207" mass="23203" checksum="BA80EF412AD56BA0" modified="2011-05-03" version="1">MAIERYFIREAVKEMLIDEYLEKELRRAGYGGLDIKKTPLGTKVIIFAANPGYVIGRGGRRIRELTRILERQFGLENPQIEVEEIKNPYLNAKVQAVRLAQALERGVHFRRAAYAAIRAIMRNGARGVEIRLSGKLTGERAKSIRFYQGYLAKVGNPAETLVSKGYAQALLKLGVIGVKVAIMPPEARLPDEIEIIEKPLEEEVSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHB9</accession>
    <name>F0LHB9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl24</name>
        <name evidence="4" type="ordered locus">TERMP_00103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Located at the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="2">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466379.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00103"/>
    <dbReference type="EnsemblBacteria" id="ADT83081">
        <property type="protein sequence ID" value="ADT83081"/>
        <property type="gene ID" value="TERMP_00103"/>
    </dbReference>
    <dbReference type="GeneID" id="26135419"/>
    <dbReference type="KEGG" id="tba:TERMP_00103"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.104"/>
    <dbReference type="eggNOG" id="arCOG04094">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093240_2_1_2"/>
    <dbReference type="OMA" id="VRIMRGD"/>
    <dbReference type="OrthoDB" id="107015at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_L24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_L26/L24P_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="PTHR11143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="3">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="120" mass="14231" checksum="33DF2FB539728AC2" modified="2011-05-03" version="1">MRLKSKQPRKQRKFLYNAPLHLRHKIMSATLSPELREKYGVRNLPIRTGDKVRIMRGDYKGIEGKVVEVDLKRYRIYVEGVTLKKVNGTEVFYPIHPSNVMIVELNLDDERRKKIIERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHD1</accession>
    <name>F0LHD1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467556.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01283"/>
    <dbReference type="EnsemblBacteria" id="ADT84258">
        <property type="protein sequence ID" value="ADT84258"/>
        <property type="gene ID" value="TERMP_01283"/>
    </dbReference>
    <dbReference type="GeneID" id="10041599"/>
    <dbReference type="KEGG" id="tba:TERMP_01283"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1285"/>
    <dbReference type="eggNOG" id="arCOG02197">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1830686_0_0_2"/>
    <dbReference type="OMA" id="GENFIVA"/>
    <dbReference type="OrthoDB" id="109859at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="SSF143870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="140" mass="15570" checksum="BBA905E82FD1784C" modified="2011-05-03" version="1">MKVVKLGKHEIAISRIVLGDVSWIFEELGDNMQIASVECWEQLVFATILALKSFERGTNKAKTVKGEILLRLAGTLQIGEAIKKVGAKKGENFIVAFGQNARKTLEDFLKKNSLKEIPLVDCDVEKVKRLFEQAAIVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHG3</accession>
    <name>F0LHG3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Indolepyruvate oxidoreductase subunit IorA</fullName>
            <shortName evidence="13">IOR</shortName>
            <ecNumber evidence="3 13">1.2.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Indolepyruvate ferredoxin oxidoreductase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">TERMP_01315</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:12645"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57271"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="EC" id="1.2.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 13">Heterodimer of the IorA and IorB subunits.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.8" evidence="3 13"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467588.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01315"/>
    <dbReference type="EnsemblBacteria" id="ADT84290">
        <property type="protein sequence ID" value="ADT84290"/>
        <property type="gene ID" value="TERMP_01315"/>
    </dbReference>
    <dbReference type="GeneID" id="10041631"/>
    <dbReference type="KEGG" id="tba:TERMP_01315"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1316"/>
    <dbReference type="eggNOG" id="arCOG01609">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017727_0_0_2"/>
    <dbReference type="OMA" id="IGDSTFM"/>
    <dbReference type="OrthoDB" id="20764at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043805">
        <property type="term" value="F:indolepyruvate ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017721">
        <property type="entry name" value="IorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="PTHR43710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006439">
        <property type="entry name" value="Indolepyruvate_ferr_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03336">
        <property type="entry name" value="IOR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="15">
        <location>
            <begin position="583"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="15">
        <location>
            <begin position="614"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR006439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR006439-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADT84290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="645" mass="70609" checksum="4732EF44248B2E63" modified="2011-05-03" version="1">MAKVTDIVLWDKPGEKVLLLGNHAIARGALEANIAVFAAYPGTPSSELTDTMAAVAEKAGVYMEYSTNEKVAFETALSAAWSGLRAMTAMKHVGLNVAADTFLSAVGMGVEGGFVIMVADDPSMWSSQNEQDTRVYAKFANVPVLEPSSPHEAKEMTKYAFELSEKFKHMVILRTTTRISHARGDVILGELPEEIKQAKRKFGDFKKDPSRFVDVPSNARKFHPQILEKIEKIREELAKCPFNWIEGKEDAKVGIIAPGLAYSYVKEALAWLGVDEVKILKLGTPFPVPYKLLEKFFNGLERVLIVEELEPVVEEQVKVWAFDNGIRIPIHGKDYVPRVYEMTTRRAVTAIAKFLGLETPIDFESVDGKYKKVSAIVPPRPPSLCPACPHRNTFYAIRKAAGSKAIFPSDIGCYTLGVLPPLKTVDTTVAMGASIGVAHGLDVALNGVPGEKDTKEKKKVIVATIGDSTFFHTGLPALANAIYNRSNVVIVVVDNLVTAMTGDQPNPGTGDTPHGPGKRILIEEVARAMGADFVEVVDPYDIKATYEVMKKAIETEGVSVVVARRVCALHHIGQLRRRGEKWLIYTVNEDKCTGCKICINAYGCPAIYWDAEKKKAQVNPLMCWGCGGCAQVCPFGAFEVMKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHK3</accession>
    <name>F0LHK3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467628.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01355"/>
    <dbReference type="EnsemblBacteria" id="ADT84330">
        <property type="protein sequence ID" value="ADT84330"/>
        <property type="gene ID" value="TERMP_01355"/>
    </dbReference>
    <dbReference type="GeneID" id="10041671"/>
    <dbReference type="KEGG" id="tba:TERMP_01355"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1355"/>
    <dbReference type="eggNOG" id="arCOG03099">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086615_2_2_2"/>
    <dbReference type="OMA" id="TYLYVHW"/>
    <dbReference type="OrthoDB" id="78706at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34584">
        <property type="entry name" value="PTHR34584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019239">
        <property type="entry name" value="MrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="201" mass="23512" checksum="313DC66D2B30F471" modified="2011-05-03" version="1">MSRIPFYLKERLEEVQRRIVYESYEAQKLPVWERIVLTWILLFSFWIVITANTSLDNLIIGAIATLIIASFMRDMLMEDVRHRGHLIEKIVYFLLLYAPQYLIIMAFRLIESNIKVAKNVILMDINPGIIKIKTDLHSDTGITILANSITLTPGTLTLDVSERLGETYLYVHWIDVETLNREKAGEKIKGDIEEWLKKIFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHL9</accession>
    <name>F0LHL9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83103">
        <property type="protein sequence ID" value="ADT83103"/>
        <property type="gene ID" value="TERMP_00125"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00125"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.126"/>
    <dbReference type="HOGENOM" id="CLU_3283042_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="40" mass="4739" checksum="67AE0E88C719405A" modified="2011-05-03" version="1">MLMDKTNNAISIFKSQPSLPILFRYTKRKRKYNEPINIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHQ0</accession>
    <name>F0LHQ0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="9">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">trpB</name>
        <name evidence="11" type="ordered locus">TERMP_00157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466432.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00157"/>
    <dbReference type="EnsemblBacteria" id="ADT83134">
        <property type="protein sequence ID" value="ADT83134"/>
        <property type="gene ID" value="TERMP_00157"/>
    </dbReference>
    <dbReference type="GeneID" id="10040475"/>
    <dbReference type="KEGG" id="tba:TERMP_00157"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.158"/>
    <dbReference type="eggNOG" id="arCOG01432">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042858_1_0_2"/>
    <dbReference type="OMA" id="MLHQTII"/>
    <dbReference type="OrthoDB" id="24741at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006316">
        <property type="entry name" value="Trp_synth_b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF6">
        <property type="entry name" value="PTHR48077:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500824">
        <property type="entry name" value="TrpB_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01415">
        <property type="entry name" value="trpB_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="10">
        <location>
            <begin position="78"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="446" mass="49563" checksum="C1853BB5FCB94DD6" modified="2011-05-03" version="1">MEKVKAVLKPEEMPKKWYNILPDLPEPLAPPLDQETDKPINPEKLKRIFAEELVKQEMSSKRFIEIPEEILEVYIKIGRPTPLFRATHLEKALKTPARIYFKYEGATITGSHKINTALAQAYYAKNQGIERLVTETGAGQWGTALSLAGALFGLKIRVYMARASYQQKPYRKILMQTYGAEIYPSPSDRTSIGRKFLAQDPNHPGGLGIAISEAIEDVLNDENARYSLGSVLNHVLMHQTIIGEEARLQMELLDEEPTTIVGCVGGGSNFAGLAYPFVRDVLKGKAGYEFYAIEPRAAPSMTRGVYTYDYGDSGRLTPKIKMHTLGHTYYVPPIHAGGLRYHGLAPTLSILINHGIVKPKAYHQTEIFEAAVLFARTEGIVPAPESAHAVKGVIDLALKAKENGEKKVILFNLSGHGLLDLKGYEDFLEGRLNDYEPKEFPILEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHT8</accession>
    <name>F0LHT8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01363"/>
    <dbReference type="EnsemblBacteria" id="ADT84338">
        <property type="protein sequence ID" value="ADT84338"/>
        <property type="gene ID" value="TERMP_01363"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01363"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1363"/>
    <dbReference type="eggNOG" id="arCOG04355">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052472_0_0_2"/>
    <dbReference type="OMA" id="PVQSMFI"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="252" mass="28567" checksum="4CB9486FBEBEBDB7" modified="2011-05-03" version="1">METIAIALLVLSADYLLILKNLTLAKAFWLIGMSLTIFFAFLIPYLMFIQERIDIKNVTPAWFIPPVGLIVIPLSGGALINTFSGIWREVTMFINYFAWGAGFFLYLALSAIVMHRFIAHEPLPCGIAPAIWINLGPIGAGTSTLYMLVKNSEFITMKEPFLAFGLIFWGFDVWWFVMAIILTLHYIRKLDLPYSLAWWAFIFPLGAYVSATHNVALAFKINIIDSFGFALYWLLFALWLITGIKTLKNTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHY2</accession>
    <name>F0LHY2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467680.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01407"/>
    <dbReference type="EnsemblBacteria" id="ADT84382">
        <property type="protein sequence ID" value="ADT84382"/>
        <property type="gene ID" value="TERMP_01407"/>
    </dbReference>
    <dbReference type="GeneID" id="10041723"/>
    <dbReference type="KEGG" id="tba:TERMP_01407"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1407"/>
    <dbReference type="eggNOG" id="arCOG02764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_10_4_2"/>
    <dbReference type="OMA" id="KINNMSC"/>
    <dbReference type="OrthoDB" id="123956at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="68" mass="7516" checksum="15B30350DA56C9A6" modified="2011-05-03" version="1">MAKVILKIKNMSCGHCAMTIKRALEKIGAKADVSLEEKMAVVEYDESRLKIEDLINAVAKFGYEAEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHY3</accession>
    <name>F0LHY3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF302 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467681.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01408"/>
    <dbReference type="EnsemblBacteria" id="ADT84383">
        <property type="protein sequence ID" value="ADT84383"/>
        <property type="gene ID" value="TERMP_01408"/>
    </dbReference>
    <dbReference type="GeneID" id="10041724"/>
    <dbReference type="KEGG" id="tba:TERMP_01408"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1408"/>
    <dbReference type="eggNOG" id="arCOG02761">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1998857_0_0_2"/>
    <dbReference type="OMA" id="LPSVAWK"/>
    <dbReference type="OrthoDB" id="98045at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="SSF103247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="1">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="125" mass="14433" checksum="B0EF07A598FC83D2" modified="2011-05-03" version="1">MKFYYVRRFERDLDGLWEELKRKIEEEGFLIVGERIPVSIVEREDGIIADYHVLFICDREVVAELVRLDPNIGALMPCTAFGYVREDGVYIGIGLPSVAWKIAGEKVVELMKPMEEKLKKIIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHZ9</accession>
    <name>F0LHZ9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467697.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01424"/>
    <dbReference type="EnsemblBacteria" id="ADT84399">
        <property type="protein sequence ID" value="ADT84399"/>
        <property type="gene ID" value="TERMP_01424"/>
    </dbReference>
    <dbReference type="GeneID" id="26136920"/>
    <dbReference type="KEGG" id="tba:TERMP_01424"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1424"/>
    <dbReference type="eggNOG" id="arCOG00288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_3_2"/>
    <dbReference type="OMA" id="HPYAKML"/>
    <dbReference type="OrthoDB" id="121018at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="179" mass="20709" checksum="C06F81105C531E0C" modified="2011-05-03" version="1">MELFEVLRRRRSIRRFQEKAVPREIIEKLLEAAFLSPSSYNKRPWHFIVVDDRELLKKLSKAKLGASGLATASVAIVVTADESRSDVWIEDASIAAEHIQLAAVALGLGSFWIQIRNRMHDEEKTAEEYVRDLLNIPKNYRVLCIIGIGYPAEKKRPHGKDIFEWEKVSYNRFGEHFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI04</accession>
    <name>F0LI04_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467702.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01429"/>
    <dbReference type="EnsemblBacteria" id="ADT84404">
        <property type="protein sequence ID" value="ADT84404"/>
        <property type="gene ID" value="TERMP_01429"/>
    </dbReference>
    <dbReference type="GeneID" id="10041745"/>
    <dbReference type="KEGG" id="tba:TERMP_01429"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1429"/>
    <dbReference type="eggNOG" id="arCOG00280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031945_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008900">
        <property type="entry name" value="Zot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05707">
        <property type="entry name" value="Zot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="184"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="600" mass="68391" checksum="CC72C37DABED41B4" modified="2011-05-03" version="1">MNESIKEKIESGISRSADWIGVVISPSTNLTLNVELLETAYEKGIVGNPCVIPFSQDGLPTYALGQITSIQLRNPHIERHPIQKIISVRGEANPLTTKHDTRQIEIGISAVYSVQEDKVIPTRMASVPPTGTRVYLLSQEILDALMEPHKDELFYVGKIYNTNIYLPMIFKHFGKSDDGRGLGEAYHIGVFGKTGSGKSYMARMLIIAYARHPEMSIVVLDPQGEFSKEIKENGILRKILQQKLNRKVEVWPITNISLSDPGTFKKILMVSGFLHKMGIKSPENQEIAADLIVSYLQNPKNYEKKKKEKITYHLSRTSLIPTSIETAHHRGVFMKVIEFIQLEDTLKRIYASEDRRRRIVTAIETRFEELYEDWKRITLLFAKDVESKLPLQQLIQKIAYEKVILFIDLSEQGAEEIFWNDKIQRLVLNDIINALKQVGNEKFKQGEQLNTLVVIDEAHRFAPRERQEEEELEALRINFVDAVRTTRKYGLGWMFISQTIASLHPELINQMRVYFFGYGLSWGSELRTLKEIVGGGMNNNYLALYQSFKDPQSSAVLGEREYPFMVFGPVSPLSVSGAPLFITALKYDSEFLVANNLSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI82</accession>
    <name>F0LI82_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C5-epim_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467710.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01437"/>
    <dbReference type="EnsemblBacteria" id="ADT84412">
        <property type="protein sequence ID" value="ADT84412"/>
        <property type="gene ID" value="TERMP_01437"/>
    </dbReference>
    <dbReference type="GeneID" id="10041753"/>
    <dbReference type="KEGG" id="tba:TERMP_01437"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1437"/>
    <dbReference type="eggNOG" id="arCOG07790">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040765_0_0_2"/>
    <dbReference type="OMA" id="HYNFRGL"/>
    <dbReference type="OrthoDB" id="21365at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047464">
        <property type="term" value="F:heparosan-N-sulfate-glucuronate 5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010598">
        <property type="entry name" value="C5-epim_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039721">
        <property type="entry name" value="C5-epimerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13174">
        <property type="entry name" value="PTHR13174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06662">
        <property type="entry name" value="C5-epim_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C5-epim_C" evidence="1">
        <location>
            <begin position="192"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="367" mass="42670" checksum="3B0D97E0BFF26CB6" modified="2011-05-03" version="1">MREKALILVFMLLTSSLFAIYENAENRISAQTEDPELIALLQENENVVLGNFISFLSAVNPLYLISSFEASYPLLVFSKIKLTPERNKILKATLRANNEFYSHYLSPLKSFYAVSFTSSAPYNSVFLANSSFKSALPYVHYNFRGLVLYPVTALHWADVYFQMGKEENAMEILRELQSYLVTKNYQGLEYAVFENYFHFENSSIPWISGYAQGLGAGLYARAYNITKNESYLRTAQLLMNSFRIPYSKGGFIVNSTYGLWILEYAYNSNELVLNGHIIALQGVYYYWEITNDTYAKWVFDEGIKAVEKALPDFDENGWSLYSNIHGRAMKNYHELHIQLLEWLYEKTKNEKFKEYAEKWRKSLQNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LII7</accession>
    <name>F0LII7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466559.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00284"/>
    <dbReference type="EnsemblBacteria" id="ADT83261">
        <property type="protein sequence ID" value="ADT83261"/>
        <property type="gene ID" value="TERMP_00284"/>
    </dbReference>
    <dbReference type="GeneID" id="26135627"/>
    <dbReference type="KEGG" id="tba:TERMP_00284"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.284"/>
    <dbReference type="eggNOG" id="arCOG01856">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2353358_0_0_2"/>
    <dbReference type="OMA" id="RYYPIEE"/>
    <dbReference type="OrthoDB" id="117979at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="97" mass="11289" checksum="7F57004B22006814" modified="2011-05-03" version="1">MEIDRIYESLKTVKEPISGENIVKLGIVTKIVRDNGKIVIYLDLARRTPQSPFEMAITWTVHAKIVKEIVKVLEDKIPEFEIIDSMTLQRYYPLEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIJ7</accession>
    <name>F0LIJ7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466569.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00294"/>
    <dbReference type="EnsemblBacteria" id="ADT83271">
        <property type="protein sequence ID" value="ADT83271"/>
        <property type="gene ID" value="TERMP_00294"/>
    </dbReference>
    <dbReference type="GeneID" id="10040612"/>
    <dbReference type="KEGG" id="tba:TERMP_00294"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.294"/>
    <dbReference type="eggNOG" id="arCOG00722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154570_5_2_2"/>
    <dbReference type="OMA" id="CVEDFMK"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="76" mass="8888" checksum="B1CECB7B2D88A2F1" modified="2011-05-03" version="1">MSEVILHLPAWIDEREARIALAVELYREGKITLKQAAEIANLCVEDFMKELSKRKVSILNWNEKELEEEIENADNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIM6</accession>
    <name>F0LIM6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00323"/>
    <dbReference type="EnsemblBacteria" id="ADT83300">
        <property type="protein sequence ID" value="ADT83300"/>
        <property type="gene ID" value="TERMP_00323"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00323"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.323"/>
    <dbReference type="eggNOG" id="arCOG04026">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1811545_0_0_2"/>
    <dbReference type="OMA" id="NYWANYW"/>
    <dbReference type="OrthoDB" id="94930at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007166">
        <property type="entry name" value="Class3_signal_pept_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04021">
        <property type="entry name" value="Class_IIIsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="144" mass="16559" checksum="D8AA3F21A09FEA3F" modified="2011-05-03" version="1">MWIKKGQGSLEYLFIVALVIIIVAIGVMYLKGAAKEVPYYNEITLDPGLFNNITADYGDIKVEAYLINNGDGTYKVEYKVWAIKVPIRKAQLALICMNKPPNVAGYKVITHEGLLTPVNYWANYWTPIPEEYFPCEIRFYIWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIN1</accession>
    <name>F0LIN1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466603.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00328"/>
    <dbReference type="EnsemblBacteria" id="ADT83305">
        <property type="protein sequence ID" value="ADT83305"/>
        <property type="gene ID" value="TERMP_00328"/>
    </dbReference>
    <dbReference type="GeneID" id="10040646"/>
    <dbReference type="KEGG" id="tba:TERMP_00328"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.328"/>
    <dbReference type="eggNOG" id="arCOG02006">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055360_2_2_2"/>
    <dbReference type="OMA" id="CNTAHFF"/>
    <dbReference type="OrthoDB" id="67642at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF7">
        <property type="entry name" value="PTHR21198:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="230" mass="25546" checksum="FCBBDB8E3C011FD7" modified="2011-05-03" version="1">MGKEKIIGILGGMGPMATVELFKRIVLKTPAKRDQDHPRIIIYNNPKIPDRTAYILGKGENPLPELIDSAKKLESWGADFIIMPCNTAHFFADEIQRAINIPLINMIEETAEYVKQLGIKRVGLLATTGTVVSGIYQRALEKKGIKVIIPNKEEQENVMRGIYEGIKANKFEFGRELLLEIAKKLEKESEGIIAGCTEVSVALKPEDLEVPLIDPMDVIAEKAVKLALNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIQ2</accession>
    <name>F0LIQ2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic divalent cation tolerance cutA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01529"/>
    <dbReference type="EnsemblBacteria" id="ADT84504">
        <property type="protein sequence ID" value="ADT84504"/>
        <property type="gene ID" value="TERMP_01529"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01529"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1529"/>
    <dbReference type="eggNOG" id="arCOG04231">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098807_3_1_2"/>
    <dbReference type="OMA" id="VYTTFPD"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="104" mass="12467" checksum="6ADD6A042E53E7E7" modified="2011-05-03" version="1">MSEMILVYTTFPDWESAERIVKELLEKKLVACVNLREHKAFYWWEGKIEEDTEVGAILKTKVELWEELKKELKEKHPYTVPAIIRIDVDTVNKEYLKWLLEVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIT3</accession>
    <name>F0LIT3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyruvate/ketoisovalerate oxidoreductases common subunit gamma</fullName>
            <ecNumber evidence="5">1.2.7.1</ecNumber>
            <ecNumber evidence="4">1.2.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_01560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:11712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="EC" id="1.2.7.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:12765"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="1.2.7.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterotetramer of one alpha, one beta, one delta and one gamma chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.1" evidence="5"/>
    <dbReference type="EC" id="1.2.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01560"/>
    <dbReference type="EnsemblBacteria" id="ADT84535">
        <property type="protein sequence ID" value="ADT84535"/>
        <property type="gene ID" value="TERMP_01560"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01560"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1560"/>
    <dbReference type="eggNOG" id="arCOG01603">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_2_0_2"/>
    <dbReference type="OMA" id="YEIASEW"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043807">
        <property type="term" value="F:3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011894">
        <property type="entry name" value="PorC_KorC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02175">
        <property type="entry name" value="PorC_KorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="8">
        <location>
            <begin position="11"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="186" mass="19940" checksum="49E113BD5FFDF926" modified="2011-05-03" version="1">MMIEVRFHGRGGQGAVTAANILAEAAFIEGKYVQAFPFFGVERRGAPVTAFTRIDEKPIRIKTQIYEPDIVVVLDPSLLETVDVTAGLKDGGIVIVNTEKSKDEVLAKLKKKPAKLALVDATTIALEVLGLPITNTSILGAVAKATGIVKIESVETAIKETFSGELGEKNARAAREAFEKTAVYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIV6</accession>
    <name>F0LIV6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01583</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467856.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01583"/>
    <dbReference type="EnsemblBacteria" id="ADT84558">
        <property type="protein sequence ID" value="ADT84558"/>
        <property type="gene ID" value="TERMP_01583"/>
    </dbReference>
    <dbReference type="GeneID" id="26137217"/>
    <dbReference type="KEGG" id="tba:TERMP_01583"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1583"/>
    <dbReference type="eggNOG" id="arCOG02312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_2"/>
    <dbReference type="OMA" id="IQKYPAT"/>
    <dbReference type="OrthoDB" id="45576at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MacB_PCD" evidence="7">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="6">
        <location>
            <begin position="306"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="407" mass="45301" checksum="BEF06CC4BDC0AFCF" modified="2011-05-03" version="1">MWSELIKIAIRNLTRRKLRTLFTMLGIIIAVGSVTALVSITQGSRMAIEQELESTSNVLMIMPGVSVSIIRAATSTMSEDIVRKIEKIDHVEAVNPALIKFTTIKYDDWILELTIMGVDPKKAQKFFALRGLHLERGVFLRKNDRYKAILGYLLAHGKFATFDGKPLNWDITPGQRIIIYDDQGNPYEFKVVGNLEESGQSFLAGFLDMMVVVPLDTLQEMFHEEGKISIVDVWVDDVAFIDEVKKEIEKEIPGVTVITARQSVQMVLIIQKMMHNLLIGIGSIALFVGALGVMNTLLTSVMERTREIGTYRAIGAKKSFILKMIFIEGIILTSIGGILGFFFGIGAAKMVVFIFRQRGQLLPDPVVDMNVVAIAFVITLLIGIISSLYPAKKASDLSPVEALRYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIX4</accession>
    <name>F0LIX4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466618.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00343"/>
    <dbReference type="EnsemblBacteria" id="ADT83320">
        <property type="protein sequence ID" value="ADT83320"/>
        <property type="gene ID" value="TERMP_00343"/>
    </dbReference>
    <dbReference type="GeneID" id="10040661"/>
    <dbReference type="KEGG" id="tba:TERMP_00343"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.343"/>
    <dbReference type="eggNOG" id="arCOG00551">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1438179_0_0_2"/>
    <dbReference type="OMA" id="EYGPFKA"/>
    <dbReference type="OrthoDB" id="86105at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="190" mass="21943" checksum="26013B19C3C75F71" modified="2011-05-03" version="1">MDIVKLRELLERELSSNDLSPLDEEFYREFDSLVRALKLRAESSKERGETVEERLYLAELNIAEHLMKEIIKIRLHKIVDLAFEGRPQSLVSEEKKIFAILMAFINREPLPLSEDVEFKETLEEKSGIEVPVGKRAIWEAYLIKVDIPRVLDEKLREYGPFKAGDLVTLPKSIGKILVERDAAKLIDINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIY2</accession>
    <name>F0LIY2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00351"/>
    <dbReference type="EnsemblBacteria" id="ADT83328">
        <property type="protein sequence ID" value="ADT83328"/>
        <property type="gene ID" value="TERMP_00351"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00351"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.351"/>
    <dbReference type="eggNOG" id="arCOG01105">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1500353_0_0_2"/>
    <dbReference type="OMA" id="TQERSHY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="16"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="180" mass="20779" checksum="234E1F25731379BE" modified="2011-05-03" version="1">MEEEIVKKLEKLSEREILGYAIASEEDAIQFYLKLSEGRGELIAEFFKDLAKAEQAHKTLLLNLHENLFGSREYTVPEDVPFAESTVNIVTLGNLVEALKTALMNEKTAERVYTLLAKKLPEHRILFDFLAAQERAHYRAIEAHEEYLEGLMRGKPEYVEAPPHVIFNQVEIYYKPRTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ07</accession>
    <name>F0LJ07_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">aIF2-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 9">eIF-2-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">eif2a</name>
        <name evidence="11" type="ordered locus">TERMP_00376</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterotrimer composed of an alpha, a beta and a gamma chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466651.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00376"/>
    <dbReference type="EnsemblBacteria" id="ADT83353">
        <property type="protein sequence ID" value="ADT83353"/>
        <property type="gene ID" value="TERMP_00376"/>
    </dbReference>
    <dbReference type="GeneID" id="26135719"/>
    <dbReference type="KEGG" id="tba:TERMP_00376"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.376"/>
    <dbReference type="eggNOG" id="arCOG04107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033458_0_2_2"/>
    <dbReference type="OMA" id="DVNEHQR"/>
    <dbReference type="OrthoDB" id="84684at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00231">
        <property type="entry name" value="eIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022964">
        <property type="entry name" value="TIF2_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="PTHR10602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="SSF110993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="SSF116742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT83353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="275" mass="31824" checksum="A02AE58D2EDF709A" modified="2011-05-03" version="1">MPRRAREFPEEGEFVIATVKSIHPYGAFLTLDEYPGKEGFMHISEVASTWVKNIRDYLKEGQKVVAKVIRVDPRKGHIDLSLKRVTQQQRKAKIQEFKRAQKAENLLKMAAEKIGKDFETAWREVWVPLEEEYGEVYAAFEDAAQNGIEVLKDLVPEEWLPVLEEIIKSYVEIPTVTIDAEFEITVPKPNGIEIIKEALIRARDRANKEKDIEVKFTYQGAPRYRIDITAPDYYKAEEVLEDIAEEILRVIKKAGGEATLIRKEKRIKKIKRRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ08</accession>
    <name>F0LJ08_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ribosome biogenesis protein Nop10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nop10</name>
        <name evidence="8" type="ordered locus">TERMP_00377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466652.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00377"/>
    <dbReference type="EnsemblBacteria" id="ADT83354">
        <property type="protein sequence ID" value="ADT83354"/>
        <property type="gene ID" value="TERMP_00377"/>
    </dbReference>
    <dbReference type="GeneID" id="26135720"/>
    <dbReference type="KEGG" id="tba:TERMP_00377"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.377"/>
    <dbReference type="eggNOG" id="arCOG00906">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196480_1_0_2"/>
    <dbReference type="OMA" id="FRIRKCP"/>
    <dbReference type="OrthoDB" id="130364at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00803">
        <property type="entry name" value="Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023532">
        <property type="entry name" value="Nop10_arc-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="PTHR13305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="SSF144210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="60" mass="7097" checksum="33FD6E31FD0F02AB" modified="2011-05-03" version="1">MRFRIRKCPKCGRYTLKETCPACGEKTKVAHPPRFSPEDPYGEYRRKLKRELLGIGRRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ14</accession>
    <name>F0LJ14_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_00383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466658.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00383"/>
    <dbReference type="EnsemblBacteria" id="ADT83360">
        <property type="protein sequence ID" value="ADT83360"/>
        <property type="gene ID" value="TERMP_00383"/>
    </dbReference>
    <dbReference type="GeneID" id="10040701"/>
    <dbReference type="KEGG" id="tba:TERMP_00383"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.383"/>
    <dbReference type="eggNOG" id="arCOG02108">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152343_0_0_2"/>
    <dbReference type="OMA" id="MDIVAML"/>
    <dbReference type="OrthoDB" id="113565at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="132" mass="15665" checksum="2A0C7D811C63314B" modified="2011-05-03" version="1">MRRQRYLEKLEKFEEEYEFIKRHEMKDEVTQRALLYSLQLCVDIAMDVVAMLTKDLGITVEDDYTNIERLLEKGVISKNEAELLKRFNGLRNAIVHKYDRLNLTVVKEGLHKIDELYKVVVKLIEKYEALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ22</accession>
    <name>F0LJ22_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ordered locus">TERMP_00391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466666.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00391"/>
    <dbReference type="EnsemblBacteria" id="ADT83368">
        <property type="protein sequence ID" value="ADT83368"/>
        <property type="gene ID" value="TERMP_00391"/>
    </dbReference>
    <dbReference type="GeneID" id="10040709"/>
    <dbReference type="KEGG" id="tba:TERMP_00391"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.391"/>
    <dbReference type="eggNOG" id="arCOG04131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_0_2_2"/>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="OrthoDB" id="99734at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="31"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="280" mass="32566" checksum="634EFC9428683A16" modified="2011-05-03" version="1">MLKSRLFSLLSKYNLRINSDLGQNFLIVDDIIKREVERAEIKANETVLEIGPGLGFLTDELSKYAKKVYAVEKDSRLVEILQKEYSWKNVEIIRGDALKVEFPEFDKIVSNLPYQISSPITFKFLRYDFKKAVLIYQLEFAQRMTAKPGDKNYSRLSVMVQAKADVELVERIGRGAFYPKPKVDSAVIILNPKPKEEQIELDDSLVKALFQHRRKKASKALKDSYHMLELTKEKFKEIRRIFDKIPHAEKRVFQLSIWEIKDIEEFLRKEGILGCSITGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ26</accession>
    <name>F0LJ26_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase Pus10</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine 54/55 synthase</fullName>
            <shortName evidence="4">Psi54/55 synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pus10</name>
        <name evidence="7" type="ordered locus">TERMP_00395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(54) in tRNA = pseudouridine(54) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:57876"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14141"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466670.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00395"/>
    <dbReference type="EnsemblBacteria" id="ADT83372">
        <property type="protein sequence ID" value="ADT83372"/>
        <property type="gene ID" value="TERMP_00395"/>
    </dbReference>
    <dbReference type="GeneID" id="10040713"/>
    <dbReference type="KEGG" id="tba:TERMP_00395"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.395"/>
    <dbReference type="eggNOG" id="arCOG01015">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028780_2_0_2"/>
    <dbReference type="OMA" id="DGGLYIK"/>
    <dbReference type="OrthoDB" id="61936at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01893">
        <property type="entry name" value="Pus10_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005912">
        <property type="entry name" value="Pus10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="PTHR21568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01213">
        <property type="entry name" value="pseudo_Pus10arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="THUMP" evidence="6">
        <location>
            <begin position="45"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="389" mass="45162" checksum="433070740183A7DD" modified="2011-05-03" version="1">MILEKSEKILEKHSLCNNCLGRLFGRLGKSTNYIRGKSIRLVLNMKREAEGLPTFGEPEKCELCGNIFKKTEYLARLCYDKAQKLGLEFESFLVGSRFPKEILEKEKQLWEEFGLEFAEPINRELNREVGKFLEVLLQKPVNKEDPDVVFIIDPYNERTELQIKPLYIYGRYRKLVRGIPQTPLKGFKESVASIICRPFSKATKGKCIFHGAGREDVDVRMLGNGRPFVVEIKKPIKRKIDLEKIAQEINQSKKVEVLDLKFITREEMEKILTSNHKKEYEALVYVEEGITEEDVKRVVEKLQNCTIYQRTPRRVLRRRADIVRVRKVYDVKAEIVDKKHLKLRLITDGGLYIKELISGDNGRTTPSVSEILGKKAWCEKLDVLNILDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ61</accession>
    <name>F0LJ61_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xanthine/uracil/thiamine/ascorbate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467881.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01608"/>
    <dbReference type="EnsemblBacteria" id="ADT84583">
        <property type="protein sequence ID" value="ADT84583"/>
        <property type="gene ID" value="TERMP_01608"/>
    </dbReference>
    <dbReference type="GeneID" id="26137195"/>
    <dbReference type="KEGG" id="tba:TERMP_01608"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1608"/>
    <dbReference type="eggNOG" id="arCOG02807">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024508_0_1_2"/>
    <dbReference type="OMA" id="RKGSYFF"/>
    <dbReference type="OrthoDB" id="29114at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="454" mass="48221" checksum="97F1A971B5EA399C" modified="2011-05-03" version="1">MDAVREVEIGVKRNKNWFEEYFDFAYHNTDLRTEILAGITTFMTMAYILFVNPAILSDAIGKDAIPSLVTATALSAGLATILMGLYAKKPFALAPGMGLNAYFTYGVVKGMGYSWQVALAAVFVEGLIFIALTLTKVRSAIIHAIPLSQKYAIGAGIGLFLTIIGMQEAGFVVDSPATLITFGAQNVAKPEFWLAIFGLFFAAILISRGIKGALLISILTTTVIGIVLGITPAPDRLFAMPTLSHTFLQMDLRGLLSVGAIGVVFAFFMVDFFDTLGTITGLSAKAGFLTKEGKVPDAEKVLLTDAIGTTVGAVLGTSTVTTYIESAAGIEEGGRTGMTALVTGALFLVIGLFISPIATVIPAYATAPALIIVGYYMLSAIRGVDFSDPTEAIPAFLVLVTIPFTYSIADGIGMGFISYAVVKTLSGRYKEVHPLLYILAGIFVLYFLYLGGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ64</accession>
    <name>F0LJ64_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-fuculose phosphate aldolase</fullName>
            <ecNumber evidence="4">4.1.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-fuculose-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fuculose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:12933"/>
            <dbReference type="ChEBI" id="CHEBI:18041"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57846"/>
            <dbReference type="EC" id="4.1.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.17" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467884.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01611"/>
    <dbReference type="EnsemblBacteria" id="ADT84586">
        <property type="protein sequence ID" value="ADT84586"/>
        <property type="gene ID" value="TERMP_01611"/>
    </dbReference>
    <dbReference type="GeneID" id="10041927"/>
    <dbReference type="KEGG" id="tba:TERMP_01611"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1611"/>
    <dbReference type="eggNOG" id="arCOG04226">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_3_2_2"/>
    <dbReference type="OMA" id="ICRYGRS"/>
    <dbReference type="OrthoDB" id="101802at2157"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008738">
        <property type="term" value="F:L-fuculose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="7">
        <location>
            <begin position="7"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="187" mass="21058" checksum="28D1B6B55DB07574" modified="2011-05-03" version="1">MSQLIKSILVKYSRLAHERGLTAAFGGNLSILFNGKIFIKATGAVMDTMTEQQVAVIDLNGKQISAVKPSSEWRLHLFIYREREDIRAIAHLHPPYSIVASIILKGELPIITPEAEIYLKKIPIAEFKPAGSEELAKEVTKYIKNHDAVLMERHGIVTVGKSLREAFYKAELVEESAKLWYLIEGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJC3</accession>
    <name>F0LJC3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KaiC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01670"/>
    <dbReference type="EnsemblBacteria" id="ADT84645">
        <property type="protein sequence ID" value="ADT84645"/>
        <property type="gene ID" value="TERMP_01670"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01670"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1669"/>
    <dbReference type="eggNOG" id="arCOG01173">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_2_0_2"/>
    <dbReference type="OMA" id="SMTPIFF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="254" mass="29293" checksum="33A0A1829DE0056C" modified="2011-05-03" version="1">MVQNIFEMYEDIEKRVERVPTGIIDDLIMGGIPKGSVVLLIGDPKSGKTTFISQFVHTQLTGGYSTIGILVDIPKYEFVSNALDFGWDFMPYLEENFFILDAYSQRLRGTPKFSFDEAVVTDIRDTTQLIDAIKDVTLKILSEKNPPMITGIISSLTPIFFETDKKQIYKFLEDLKELAHRNKQVWLVEMNSGIEEPHVEMMVKAIVDGIIEMRLIEENMTLRRYLRVYGMRRTKHVLSWVPYEITETGIQLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJC6</accession>
    <name>F0LJC6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase small subunit PriS</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">priS</name>
        <name evidence="13" type="ordered locus">TERMP_01673</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="12">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467946.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01673"/>
    <dbReference type="EnsemblBacteria" id="ADT84648">
        <property type="protein sequence ID" value="ADT84648"/>
        <property type="gene ID" value="TERMP_01673"/>
    </dbReference>
    <dbReference type="GeneID" id="10041989"/>
    <dbReference type="KEGG" id="tba:TERMP_01673"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1672"/>
    <dbReference type="eggNOG" id="arCOG04110">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056123_1_0_2"/>
    <dbReference type="OMA" id="GFDHTGE"/>
    <dbReference type="OrthoDB" id="95578at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00700">
        <property type="entry name" value="DNA_primase_sml_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023639">
        <property type="entry name" value="DNA_primase_ssu_PriS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="PTHR10536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 10 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 10 11" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT84648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="345" mass="40260" checksum="DF32BA276181CA44" modified="2011-05-03" version="1">MNELFREVTKRERQLYYEKEWNAKKLPPFIVNTLENREFGFDHTGDGPSDRKNVFHDIRDLEDYVKATAPYAIFSSVALYEEPKEMSGWLGAELVFDIDAKDLPLRRCNHESGTVCPICLEDAKELAKDTLIVLKEDFGFEDIHIVYSGRGYHIRVLDEWALELDSKAREKILAYTSSAEEVTFDDIQSKRIMLSSGYFRVFRLRFGYFIMRVRYNHLKNIGLNKKQISLILSNKEKINQGFVKEARLTAFPQGIGYKTLLRLFALSTTFSKAYFDGRVTVDVKRILRVPSSLHSKVGLITTYIGSKEKELEKFNPFRDAVPKFRKEEVRQAYEEWLENNELKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJF4</accession>
    <name>F0LJF4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-ribofuranosylaminobenzene 5'-phosphate synthase</fullName>
            <shortName evidence="1">Beta-RFA-P synthase</shortName>
            <ecNumber evidence="1">2.4.2.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48556"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:82767"/>
            <dbReference type="EC" id="2.4.2.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-RFA-P synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.54" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466718.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00443"/>
    <dbReference type="EnsemblBacteria" id="ADT83420">
        <property type="protein sequence ID" value="ADT83420"/>
        <property type="gene ID" value="TERMP_00443"/>
    </dbReference>
    <dbReference type="GeneID" id="10040761"/>
    <dbReference type="KEGG" id="tba:TERMP_00443"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.443"/>
    <dbReference type="eggNOG" id="arCOG01026">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061764_0_0_2"/>
    <dbReference type="OMA" id="RLNGAWY"/>
    <dbReference type="OrthoDB" id="47243at2157"/>
    <dbReference type="UniPathway" id="UPA00065"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004422">
        <property type="entry name" value="RFAP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF6">
        <property type="entry name" value="PTHR20861:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004884">
        <property type="entry name" value="Sugar_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00144">
        <property type="entry name" value="beta_RFAP_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="2">
        <location>
            <begin position="76"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="3">
        <location>
            <begin position="203"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="323" mass="36460" checksum="FF2742E12523A389" modified="2011-05-03" version="1">MIIKTPRRLHLGLIDPSGSLGRRFGSLGVALEEGYEIKLMPHEKLEIRAEREDKETIKFIIGRMNKHFSTGFNYLVEVRKAIPRHIGLGSTTQLSLAVGVGIAKLNNINAELEELAEIFGRGKNSGAGIYTFKYGGFVIDGGVKEGIPPLIFREEFPKNWAFLLVIPQVKRGFNEEEEKPIMASIRGKSEIAKEISHRILLGLLPSLKERDIKTFGKHLSEIQRLVGKHFEDYQGGEFREDVKLIMEFLRENTYGYGQSSWGPTVYGLIQKNEYSMLKAKLHDFLKDYGLKAEIELGIPRNKGAEIVMENAYLLRLINSVAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJM3</accession>
    <name>F0LJM3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467963.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01690"/>
    <dbReference type="EnsemblBacteria" id="ADT84665">
        <property type="protein sequence ID" value="ADT84665"/>
        <property type="gene ID" value="TERMP_01690"/>
    </dbReference>
    <dbReference type="GeneID" id="10042006"/>
    <dbReference type="KEGG" id="tba:TERMP_01690"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1689"/>
    <dbReference type="eggNOG" id="arCOG00955">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061501_0_0_2"/>
    <dbReference type="OMA" id="CIFCYSN"/>
    <dbReference type="OrthoDB" id="27859at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="51"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="380" mass="43726" checksum="546A0B98089B674F" modified="2011-05-03" version="1">MKYTWEEFARKMGIEVERLENKEARELKKFVDELIVPTHCQFCQGLDLSIDNPVHHPSYELTPACNHDCIFCYSNVAVKLGKAPKPGYYGWENPKAITISQYGEPLLSPRIVEVNKMLREKFPDARLDLQTNGSLLTEELWQKLDFDLVMISLDAASREKHRMITNADTFDKVVNALKIVGSDKSVRSIVRTIFMPGINDEDIPKIAELAASLGIDEMMLQPLTIHKLNEKRLRKAGLDFERAESVRELLRIAMKAKKYIDVRIRGCLLVQLKKMDALTLYNVYKVSRDVAPLVKRERKELGEVEETCDGGVRINIGENVNIEKIEMSLKKRRIKYLKTKNLIKFTKEDVEITVFKNGKILIRGTNDKEEIKRIISEFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJR6</accession>
    <name>F0LJR6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aliphatic amidase amiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468006.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01733"/>
    <dbReference type="EnsemblBacteria" id="ADT84708">
        <property type="protein sequence ID" value="ADT84708"/>
        <property type="gene ID" value="TERMP_01733"/>
    </dbReference>
    <dbReference type="GeneID" id="10042049"/>
    <dbReference type="KEGG" id="tba:TERMP_01733"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1732"/>
    <dbReference type="eggNOG" id="arCOG00062">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_1_2"/>
    <dbReference type="OMA" id="GNTYRES"/>
    <dbReference type="OrthoDB" id="66517at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="264" mass="30230" checksum="1BBFD05F72A30074" modified="2011-05-03" version="1">MRVGFIQMEPKLLDLNANLSKAEKLLKDAAKQEAQLVVLPELFDTGYNFESREEVYSIAQQIPDGETTQFLVEQAREHEMFIIAGTAEKDEKGRLYNSAVLVGPIGWGYIGKYRKIHLFYREKLFFEPGNLGFHVFNIGVAKVGIMICFDWFFPEAMRTLALKGADIVAHPANLVMPYAPRAMPIRSLENRVFSITANRIGEERGLRFIGMSQINSPKAEILLRASEDKEEVGVVEINIEEARNKKINEYNDIFKDRQPKYYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJT7</accession>
    <name>F0LJT7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466772.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00497"/>
    <dbReference type="EnsemblBacteria" id="ADT83474">
        <property type="protein sequence ID" value="ADT83474"/>
        <property type="gene ID" value="TERMP_00497"/>
    </dbReference>
    <dbReference type="GeneID" id="10040815"/>
    <dbReference type="KEGG" id="tba:TERMP_00497"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.497"/>
    <dbReference type="eggNOG" id="arCOG03198">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_661601_0_0_2"/>
    <dbReference type="OMA" id="NNHYTVD"/>
    <dbReference type="OrthoDB" id="27582at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007503">
        <property type="entry name" value="DUF530"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014496">
        <property type="entry name" value="UCP018863"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04409">
        <property type="entry name" value="DUF530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018863">
        <property type="entry name" value="UCP018863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="416" mass="48331" checksum="360F3E80FA463BA6" modified="2011-05-03" version="1">MTTTEELVAQVNKILDDIGIDMMGLFENLDIPVLVFYLNRNLEILREFEEELSRRVGETVPSVRGIDKKEKDPHIRWLYKKKHNRILALERLRSAIVAHKMALALISANYSFYLGNREIDPKTIRKHEEIKKIKAVKKPVALGRIDVLPHLAYSGDVLRLLGQESVEVREAFKLIKSKLREKGVVRKKSFRIEVEYWDKGRLRKTRLDIPTDADIESELRKRFGKRFRWRVLSYVKTKGVLINNHYTVDNLALAYAAFDPEKGPELLGLDLFRYYFLTSEKERESLGLYPDIKLCIDCHYSVFDLPFMKEKGFRTGFGSMMIIQKCEIEKMLSGKRSEISNIPNYLLGGAILYGVSPFDEKKVAELLELDLDRLVEAIRKLVLSGLHKSLFTNLEKFEKFMPKSDKAKRFLELLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJT8</accession>
    <name>F0LJT8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Type 2 DNA topoisomerase 6 subunit A</fullName>
            <ecNumber evidence="7">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DNA topoisomerase VI subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">top6A</name>
        <name evidence="9" type="ordered locus">TERMP_00498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466773.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00498"/>
    <dbReference type="EnsemblBacteria" id="ADT83475">
        <property type="protein sequence ID" value="ADT83475"/>
        <property type="gene ID" value="TERMP_00498"/>
    </dbReference>
    <dbReference type="GeneID" id="10040816"/>
    <dbReference type="KEGG" id="tba:TERMP_00498"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.498"/>
    <dbReference type="eggNOG" id="arCOG04143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037229_1_0_2"/>
    <dbReference type="OMA" id="NWGEARF"/>
    <dbReference type="OrthoDB" id="22842at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00132">
        <property type="entry name" value="Top6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004085">
        <property type="entry name" value="TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="PTHR10848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01552">
        <property type="entry name" value="TPISMRASE6A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="SSF56726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TP6A_N" evidence="8">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="381" mass="44007" checksum="1333AD198774E774" modified="2011-05-03" version="1">MLKREMPKERFAYDPQKVLRKLEELGKEILEEVKQGKNPYLDIPTRGLNNVYFDEVKRVIRMGNKLSRRYFLNVAHARKFMQTLLIAAYVKRLVSEGKHASLREAYYANKHTIPGTKENTFEDQSESDPVIEDLERMLGVLREEMHLTADRRGYVYGDITIRDGEDEFNTSKLGMGGWAVPGTVEHIQFVDINVDYALVVETAAMADRLIEEKFPKKERALIIATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPEAKFVGMTMDDIKKYGLENVTEKLKGIPPNKKGGPTGDYKRIIEEMNYPWFQTKEWQRQLKLALQWGVRIEQQALANKSLEFVAKKYLPEKIANEELLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJV8</accession>
    <name>F0LJV8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="MEROPS" id="M20.A25"/>
    <dbReference type="EnsemblBacteria" id="ADT83495">
        <property type="protein sequence ID" value="ADT83495"/>
        <property type="gene ID" value="TERMP_00518"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00518"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.518"/>
    <dbReference type="eggNOG" id="arCOG01107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_626456_0_0_2"/>
    <dbReference type="OMA" id="LFMAHFD"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="438" mass="48536" checksum="7C3D0A6DB226BF20" modified="2011-05-03" version="1">MMELLSQLIEFETVNDPAKGKKPNKECPKFIKDALASWGIESEIIEEDGYYTVYGEIGEGTPKVMFMAHFDVVPVNVEEWKTDPFKLTVIGNKAYGRGSADDKGNVAGVMLALKELSTKRLSGKVLFAFTGDEEIGGKLAMHIAEKLKEENKIPQYLINADGAGMSPIIRRRKGFGAVIEIPQQKITIRGRVIKKSFTISTPVLQTRHAAYFMPGVDAHPMIALSHFLRNNDVFAVKLGGKFLKSNVLPSRVELTYVEPDESGEEIEVDLGLTELLKSIVPLVRAPISAERYSDFGVSITPNLYSFENGVHRLRLDIRAMSYSSGQIEKVLKEILEFNIPNAKLTVRHNEKAGYLFTSPDSKLVRVMMKILESFGEKAKPVEGAGASDSRYFTPYGVEAIDFGPRGGNVHGPNEYADVSSLELLPKIYAEVAMNLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJW6</accession>
    <name>F0LJW6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466801.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00526"/>
    <dbReference type="EnsemblBacteria" id="ADT83503">
        <property type="protein sequence ID" value="ADT83503"/>
        <property type="gene ID" value="TERMP_00526"/>
    </dbReference>
    <dbReference type="GeneID" id="10040844"/>
    <dbReference type="KEGG" id="tba:TERMP_00526"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.526"/>
    <dbReference type="eggNOG" id="arCOG03825">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1227712_0_0_2"/>
    <dbReference type="OMA" id="IEGWEND"/>
    <dbReference type="OrthoDB" id="82296at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="103"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="225" mass="24250" checksum="2F065E7D65F42519" modified="2011-05-03" version="1">MIEIIEREYEVTEGLRLVISNVSGHIKIKGYDGDTIKMRAEKKWGLFASEPKIKVKKKGNVLKIEAKHKKTFGISLGGSSVNFDILVPKTVEVKKIGSVNSRISISNVKGVIKIGNVNGSIELENVEISKVGNVNGPIKVVLKAVRNDVKISTVNGSIKFLLPKKADAMISASTTNGRILTEGFDNVATSLVGKFGPKSFSAQLGSGKYSVKVSTVNGNIELRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJY9</accession>
    <name>F0LJY9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elp3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00549"/>
    <dbReference type="EnsemblBacteria" id="ADT83526">
        <property type="protein sequence ID" value="ADT83526"/>
        <property type="gene ID" value="TERMP_00549"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00549"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.550"/>
    <dbReference type="eggNOG" id="arCOG01290">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736976_0_0_2"/>
    <dbReference type="OMA" id="FATCKEG"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Elp3" evidence="6">
        <location>
            <begin position="7"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="375" mass="43230" checksum="6CB68EAE10EC3904" modified="2011-05-03" version="1">MSGLCHSIIRGEVFTTCSLGCVYCYARWYRKDGIPKPIFDVFRLIKALGKLVEENIPVTPVRFSALSDPFQPPAKITLKALKLAYKLKVPVIVNTKLYPSEKHLKVLEDLASEGLLVLQVSITAEKDSKEVRILEPLASPIEERLKLVKKASEVGIPSVVRIQPLIPGLSDRDVENLLDEIAWAGAKMVIIEFLRVERENFEFYKRFFSKHSEVYSREWESYLPRTPSEEAPLIQVPLEYRLKTAELFAKESKRRGLAFATCKEGIFNLHEPKTMDCCGMGFLGVEWTRKPTLWDLYLKAYEKGKARAEDLWERCEREGLLCGERLKLYPSWLSKSFKAHEKRLKSILRKPELVEKLVPVLKYREGHYVINELIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJZ9</accession>
    <name>F0LJZ9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466834.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83536">
        <property type="protein sequence ID" value="ADT83536"/>
        <property type="gene ID" value="TERMP_00559"/>
    </dbReference>
    <dbReference type="GeneID" id="26135899"/>
    <dbReference type="KEGG" id="tba:TERMP_00559"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.560"/>
    <dbReference type="eggNOG" id="arCOG08353">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177474_0_0_2"/>
    <dbReference type="OMA" id="MYKRELK"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="97" mass="11003" checksum="3A492447E86C4713" modified="2011-05-03" version="1">MDPIEKMLDEAAKNPKMRRKLKVKALLSLVLFFVFLLALFTAIGMLWATKNGAFLGMTKAQIFALRTKVALIMNILIIAHIIVNRKVFVKELKILFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK21</accession>
    <name>F0LK21_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ECF transporter transmembrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01758"/>
    <dbReference type="EnsemblBacteria" id="ADT84733">
        <property type="protein sequence ID" value="ADT84733"/>
        <property type="gene ID" value="TERMP_01758"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01758"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1757"/>
    <dbReference type="eggNOG" id="arCOG02250">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_2_3_2"/>
    <dbReference type="OMA" id="NNIMIGR"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="251" mass="28622" checksum="D1CD9EC89F838AD7" modified="2011-05-03" version="1">MYTLYIERDSFLHRLDPRVKIISSLLGILAMILFNSPYLLFALFMLLSLSLRFLGKISFKEQIKVLKPLTPLIVITIAIWPFILDPKTFGLFIGLGYALRLASMAMITFGLLMTTTQRELILGFIKLKMPYEIGLTLTIALRYIPTLFGLAQTIIDAQRSRGLELEKGSFFSRIRKTVPILIPLIIASIKTAHELSIALESRAFGASRKRTFLHTIQMEKKDYVALIFVFLLFGLALYARYQLGIGYVKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK23</accession>
    <name>F0LK23_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468032.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01760"/>
    <dbReference type="EnsemblBacteria" id="ADT84735">
        <property type="protein sequence ID" value="ADT84735"/>
        <property type="gene ID" value="TERMP_01760"/>
    </dbReference>
    <dbReference type="GeneID" id="26137273"/>
    <dbReference type="KEGG" id="tba:TERMP_01760"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1759"/>
    <dbReference type="eggNOG" id="arCOG03769">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2010211_0_0_2"/>
    <dbReference type="OMA" id="VWLYALR"/>
    <dbReference type="OrthoDB" id="129715at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="124" mass="12904" checksum="5A5BE678866ACB00" modified="2011-05-03" version="1">MAPVGPMAVFGALGAMAVVMFLVIIAVDSVFLWLGAKFAKIEDASFGKAFIATLGGLIVSAILGSIVPVIGGLLGLIAFLWIVKTVFNTDWGKAVIAWLFAIVIAIILMVIIMIVVGLSVMAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK78</accession>
    <name>F0LK78_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfur carrier protein adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468086.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01815"/>
    <dbReference type="EnsemblBacteria" id="ADT84790">
        <property type="protein sequence ID" value="ADT84790"/>
        <property type="gene ID" value="TERMP_01815"/>
    </dbReference>
    <dbReference type="GeneID" id="10042131"/>
    <dbReference type="KEGG" id="tba:TERMP_01815"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1814"/>
    <dbReference type="eggNOG" id="arCOG01676">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_10_4_2"/>
    <dbReference type="OMA" id="SAKWKLE"/>
    <dbReference type="OrthoDB" id="86909at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="10"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="232" mass="25742" checksum="7734E0097CE7C5D4" modified="2011-05-03" version="1">MLTERELERYDRQIRIFGVEGQEKLKKAKVAVVGVGGLGSPVAYYLAAAGVGTLLLIDEQIPELSNLNRQILHWEEDIDKNPKPPSAKWKLERFNSDIKVETFVGKLTKENIEEILADVDVIVDCLDNFETRYLLDEFAHKRGIPLVHGAVEGMFGQVTTIIPGKTKCLREIFPKPPKKKEKFPILGATAGVIGTIQAAEVIKLITGYGEPLANKLLIVDLAHGSFEVLNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKB9</accession>
    <name>F0LKB9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein archease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00600"/>
    <dbReference type="EnsemblBacteria" id="ADT83577">
        <property type="protein sequence ID" value="ADT83577"/>
        <property type="gene ID" value="TERMP_00600"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00600"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.601"/>
    <dbReference type="eggNOG" id="arCOG04055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111362_3_0_2"/>
    <dbReference type="OMA" id="WLSELLY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01222">
        <property type="entry name" value="Archease_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022952">
        <property type="entry name" value="Archease_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="PTHR12682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="6">
        <location>
            <begin position="6"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="144" mass="16841" checksum="028D77CE8CF8C626" modified="2011-05-03" version="1">MKMRKWEHYEHTADIGIRGYGRTLEEAFENVAIALFDVMVDVEKVEPKEVREIEVSGEDLYALLYNFLEELLILHDTEGLVFSDFEVKIEKTKEGYRLKAKAYGESLDYGKHEPKEEVKAITYHDMKIEQLEDGTWIVQLVPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKC6</accession>
    <name>F0LKC6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="4">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">surE</name>
        <name evidence="6" type="ordered locus">TERMP_00607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="4">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="4"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466882.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00607"/>
    <dbReference type="EnsemblBacteria" id="ADT83584">
        <property type="protein sequence ID" value="ADT83584"/>
        <property type="gene ID" value="TERMP_00607"/>
    </dbReference>
    <dbReference type="GeneID" id="10040925"/>
    <dbReference type="KEGG" id="tba:TERMP_00607"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.609"/>
    <dbReference type="eggNOG" id="arCOG02303">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_1_3_2"/>
    <dbReference type="OMA" id="DCVHIAL"/>
    <dbReference type="OrthoDB" id="110625at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="5">
        <location>
            <begin position="4"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="261" mass="28550" checksum="DB4F1513138F4EA7" modified="2011-05-03" version="1">MPKILITNDDGIYSRGIRAAIEALRGLGDVYVVAPMFQRSASGRAMTLHRPLRAKRVTINGVKAAYALDGMPVDCVIFALARFGSFDLAISGINLGENMSTEITISGTASAAIEAATHGIPSIAISLEVNREKYKFGAGEEIDFTMAKLFLKKIAKAVLEKGLPKGVDMLNVNIPYDADESTPIEITRLARRMYQPSVEERIDPKGTPYYWIVGTQCPRDVLEPGTDMYAVKVERKVSVTPINIDMTADVDLKYLRGHLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKE2</accession>
    <name>F0LKE2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside-triphosphatase TERMP_00623</fullName>
            <shortName evidence="3">NTPase</shortName>
            <ecNumber evidence="3">3.6.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Nucleoside triphosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the THEP1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.15" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00623"/>
    <dbReference type="EnsemblBacteria" id="ADT83600">
        <property type="protein sequence ID" value="ADT83600"/>
        <property type="gene ID" value="TERMP_00623"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00623"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.625"/>
    <dbReference type="eggNOG" id="arCOG01034">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103145_1_1_2"/>
    <dbReference type="OMA" id="GAMEFKC"/>
    <dbReference type="OrthoDB" id="90019at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00796">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004948">
        <property type="entry name" value="Nuc-triphosphatase_THEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146">
        <property type="entry name" value="PTHR43146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03266">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="98"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="171" mass="19433" checksum="6611BF7358F7F9BB" modified="2011-05-03" version="1">MKIFVTGVPGVGKTTLVLKIAEDLRKSGFRIGGMVTQEVREQGKRVGFKIRALDTNEEGTLAWVGEGYPRVGKYFVNVEDLDKIGVSAIRRAIRNADVIIIDEIGAMEFKSKEFAKVIEEALRSEKPLLATLHRRWVHRFKNKGKLYVLTEENREKIREEISHELLKALSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKG0</accession>
    <name>F0LKG0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466916.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00641"/>
    <dbReference type="EnsemblBacteria" id="ADT83618">
        <property type="protein sequence ID" value="ADT83618"/>
        <property type="gene ID" value="TERMP_00641"/>
    </dbReference>
    <dbReference type="GeneID" id="10040959"/>
    <dbReference type="KEGG" id="tba:TERMP_00641"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.643"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="PVMFMDE"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="253" mass="28020" checksum="DDE48B3AFE005868" modified="2011-05-03" version="1">MIEVENLTKKFGDKIAVDGISFHVHDGEIYGLLGPNGSGKSTTMKILAGILKPTTGKVLVEGINVAKNPIEVKKIVGYVPETPILYESLTPSELFNFVGSIRGIPKDKLEERVNYFVKAFGIEEYLEQFIGTLSFGTQQKVSLITALLHDPKVLILDEAMNGLDPKSARILRELLLEFKNEGKSIVFSTHILSLAEVICDRIGVIYQGKIIAEGTIEELKEKAHEESLEDVFLKLTESKDEIVHIVQALKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKI7</accession>
    <name>F0LKI7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468117.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84821">
        <property type="protein sequence ID" value="ADT84821"/>
        <property type="gene ID" value="TERMP_01846"/>
    </dbReference>
    <dbReference type="GeneID" id="10042162"/>
    <dbReference type="KEGG" id="tba:TERMP_01846"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1845"/>
    <dbReference type="eggNOG" id="arCOG13985">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1922897_0_0_2"/>
    <dbReference type="OMA" id="VEVAYWA"/>
    <dbReference type="OrthoDB" id="135840at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="131" mass="15008" checksum="F3E27B26AFBA79BA" modified="2011-05-03" version="1">MEKLLAYVELKTQESKKKALDLIKKAGSSRGHEKRRFEVEVAYWAGKLSAYAEVRGMILRNVEAREELKQLIEKAAETALIKEKLAVLHAISKHSNHTTDIKSFERGVEELKFELFKALNLLDDVTIIEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKI8</accession>
    <name>F0LKI8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01847"/>
    <dbReference type="EnsemblBacteria" id="ADT84822">
        <property type="protein sequence ID" value="ADT84822"/>
        <property type="gene ID" value="TERMP_01847"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01847"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1846"/>
    <dbReference type="HOGENOM" id="CLU_3131032_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="49" mass="5827" checksum="7D3E78818C2B89F2" modified="2011-05-03" version="1">MEQFVTSKFGDNARILTTIVFLKNMKFYSCVKRRHERAVFWIVCGIKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKL9</accession>
    <name>F0LKL9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468149.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01878"/>
    <dbReference type="EnsemblBacteria" id="ADT84853">
        <property type="protein sequence ID" value="ADT84853"/>
        <property type="gene ID" value="TERMP_01878"/>
    </dbReference>
    <dbReference type="GeneID" id="26137396"/>
    <dbReference type="KEGG" id="tba:TERMP_01878"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1877"/>
    <dbReference type="eggNOG" id="arCOG04420">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144580_2_0_2"/>
    <dbReference type="OMA" id="IPWEESD"/>
    <dbReference type="OrthoDB" id="103620at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007417">
        <property type="entry name" value="DUF473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04322">
        <property type="entry name" value="DUF473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="126" mass="14778" checksum="729902506A8F6EE8" modified="2011-05-03" version="1">MEVLILAGITRRTLDQLLRNPYRTLEIRSASNVFVLEHLKEGDRVFLTYETLQDITKGTEGIIAQILRMEKMEQRILWEESDEREQMVCRVQLRLVGLGKVIEIRREGDLIKARVREMLPHEMAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKM7</accession>
    <name>F0LKM7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468157.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01886"/>
    <dbReference type="EnsemblBacteria" id="ADT84861">
        <property type="protein sequence ID" value="ADT84861"/>
        <property type="gene ID" value="TERMP_01886"/>
    </dbReference>
    <dbReference type="GeneID" id="10042202"/>
    <dbReference type="KEGG" id="tba:TERMP_01886"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1885"/>
    <dbReference type="eggNOG" id="arCOG01687">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121767_0_0_2"/>
    <dbReference type="OMA" id="TIYHHIE"/>
    <dbReference type="OrthoDB" id="76478at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="192" mass="22783" checksum="F13B15D416B1E79B" modified="2011-05-03" version="1">MSKKVKVITDPKVIKLMLEDTRRKILQLLRNREMTISQLSEILGKTPQTVYHHIEKLKEAGLVEVKRTEMKGNLVEKYYGRTADAFYINLYLGDEELRYFARSRLKTKLDIFKALGYEFDEEELLNTMDRILEKEHEYKMKISKEIEEKEELLKDFSNEDIIHAIEWLSMAEIGRDEEALKLLKKLGEILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKQ9</accession>
    <name>F0LKQ9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin converting factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466936.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00661"/>
    <dbReference type="EnsemblBacteria" id="ADT83638">
        <property type="protein sequence ID" value="ADT83638"/>
        <property type="gene ID" value="TERMP_00661"/>
    </dbReference>
    <dbReference type="GeneID" id="10040979"/>
    <dbReference type="KEGG" id="tba:TERMP_00661"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.663"/>
    <dbReference type="eggNOG" id="arCOG00536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_1_2_2"/>
    <dbReference type="OMA" id="MKVKFYA"/>
    <dbReference type="OrthoDB" id="123013at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010038">
        <property type="entry name" value="MoaD_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01687">
        <property type="entry name" value="moaD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="87" mass="9773" checksum="143C1334777831C8" modified="2011-05-03" version="1">MKVKFYATLRDLTGKKEIEIKGVKTVKELLDTLDKMFPGIKKELIDEDGDVNGMILVNGHNIVHLKLWDTELKEEDVVHIFPPAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKR4</accession>
    <name>F0LKR4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="5">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glmS</name>
        <name evidence="8" type="ordered locus">TERMP_00666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466941.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00666"/>
    <dbReference type="EnsemblBacteria" id="ADT83643">
        <property type="protein sequence ID" value="ADT83643"/>
        <property type="gene ID" value="TERMP_00666"/>
    </dbReference>
    <dbReference type="GeneID" id="10040984"/>
    <dbReference type="KEGG" id="tba:TERMP_00666"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.668"/>
    <dbReference type="eggNOG" id="arCOG00057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_2"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="7487at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="280"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="453"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="5">
        <location>
            <position position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="602" mass="67055" checksum="512B2AE1623BB819" modified="2011-05-03" version="1">MCGIIGYIGERKACNVLVDGLKRLEYRGYDSVGIVTEEDGKLYIRKGAGKIDELKEKLGLLEMPGKRGIGHTRWATHGIPNDINAHPHTDCTGKIAVVHNGIIENYIELKDELLRKGHKFKSDTDTEIIAHLIEDALKDFNNFEDALRYALLRLKGSFALGIIYTHDREHLYFVRNESPLVLGIGHGEMFAASDIPAFLPYTNKAVFLDDGEYAVVTKDSFVVKDLKTGQVKEKKVHEINWTLEMAEKQGYEHFMLKEIHEQPKAVKEAIYGNLGMIDKIAREIANYEKIYIVAMGTSYHAALVGKYIFQRLVKKVPVVEDASEFRYEFEDLIDRDTLVIAITQSGETADTLAAIKLAKKKGAKVLSIVNVVGSMATRLSDLVLYTHAGPEIGVAATKTYTTQLTVISMLAIALAKYLNTADREYLQKIEAELYDMPKYIEAALGYENKIKNLAERLKEKRDFFYIGRGISLATALEGALKLKEISYIHAEGLSAGELKHGPLALIEEDVPVVAIAPSGKTLEKMISNIQEAKARGALIISLGDSEELRKVSDILIKMPKVDEVLSPIVYIVPLQLLAYHLSVLRGNDPDKPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKS2</accession>
    <name>F0LKS2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83651">
        <property type="protein sequence ID" value="ADT83651"/>
        <property type="gene ID" value="TERMP_00674"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00674"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.675"/>
    <dbReference type="HOGENOM" id="CLU_219928_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="38" mass="4395" checksum="7EAF86937B3A3B9B" modified="2011-05-03" version="1">MYTFGFRIFGTSLVCFPHGNLTILKLKANKVRFLDFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKW8</accession>
    <name>F0LKW8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum cofactor biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466995.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00720"/>
    <dbReference type="EnsemblBacteria" id="ADT83697">
        <property type="protein sequence ID" value="ADT83697"/>
        <property type="gene ID" value="TERMP_00720"/>
    </dbReference>
    <dbReference type="GeneID" id="26136128"/>
    <dbReference type="KEGG" id="tba:TERMP_00720"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.722"/>
    <dbReference type="eggNOG" id="arCOG00216">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_7_2_2"/>
    <dbReference type="OMA" id="MTGAMVP"/>
    <dbReference type="OrthoDB" id="51611at2157"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="186"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="396" mass="44090" checksum="3FBC4A8FC8AD51A9" modified="2011-05-03" version="1">MREFKKLMPYKEAFQLMINDINEIPDVEEVSLDEALGRILAEDVKSPIDSPPFDRSAVDGYAVRAEDTFQAREYAPVELEVVDEITAGMESKTEVTHGKAVKLMTGNKLPKGANGVIMQEQVKREGNKIYVLRPVAPGQNVAFRGEDIKKGQIILRKGQILRPQDLSLLKSVGIKRVKVRRKPRVGIIVTGDELIEELDERALESGKILESNSIMLKGLVKQYFGEPVFYGILPDDESIIREKLEKAKSECDLVLITGGSAFGDKDFAHRFVNLLFHGTTIKPGRPVGYGERVFVLSGYPVAVFAQFHLFVKYALAKLVGANFKPAKVKARLTAKVSSTLGRYEFVKVWYEDGKAKPIRKSGSGLISSLVESNGYITIPEDSEGYLEGEEVEVVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKX9</accession>
    <name>F0LKX9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metal-dependent carboxypeptidase</fullName>
            <ecNumber evidence="1">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M32 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468182.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01911"/>
    <dbReference type="MEROPS" id="M32.002"/>
    <dbReference type="EnsemblBacteria" id="ADT84886">
        <property type="protein sequence ID" value="ADT84886"/>
        <property type="gene ID" value="TERMP_01911"/>
    </dbReference>
    <dbReference type="GeneID" id="10042227"/>
    <dbReference type="KEGG" id="tba:TERMP_01911"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1910"/>
    <dbReference type="eggNOG" id="arCOG04247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032916_1_1_2"/>
    <dbReference type="OMA" id="EFGHALY"/>
    <dbReference type="OrthoDB" id="15879at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="PTHR34217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="499" mass="58895" checksum="F1DF742BCA91AFF2" modified="2011-05-03" version="1">MKEVFQNEVIKQILLKYRTIWAIGHAQSVLGWDMEVNMPKEGITERSVAQGELSVLNQKLILDEKFVELVEKAEGEELNDYERGVVRVLKRSIKIAKAFPPEFVREMSEVRSKATMVWEEAKQKNDFKLFEPYLDKIIELSRKAADYLGYDEYPYDALLDLYEEGLKTRDLDPIFEKLEKELKPILDKILEEWKFPKEHPLEKEKYDIEAMKKVNLEVLKLFGYPIGTRGRLDVSPHPFTTEFGIKDVRITTRYEGFDFKRTLLAVVHEFGHALYELQQDERFMFSPIAGGVSLGIHESQSRFWENIIGRSREFAELVYPILRDNLPFISNYTPEDIYYYFNTVRPDFIRVEADEVTYNMHILLRYKLEKLMINEGLRASEVAELWNEEMERLLGIRPKTYSEGVLQDIHWAHATIGYFPTYTLGTLLSAQIRTYITKDIPDFYEKVQRGEFEPIKEWLREKVHKYGSVYPPKELLERSFGEGVNPEYFIEYLKEKYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKZ5</accession>
    <name>F0LKZ5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468198.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01927"/>
    <dbReference type="EnsemblBacteria" id="ADT84902">
        <property type="protein sequence ID" value="ADT84902"/>
        <property type="gene ID" value="TERMP_01927"/>
    </dbReference>
    <dbReference type="GeneID" id="10042243"/>
    <dbReference type="KEGG" id="tba:TERMP_01927"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1926"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_10_0_2"/>
    <dbReference type="OMA" id="VPDMTRW"/>
    <dbReference type="OrthoDB" id="39139at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="133"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="313" mass="34733" checksum="886793DE90CB0E49" modified="2011-05-03" version="1">MLRVGVVGVGNMGRHHARVYSELAEEGKVEFIGVADANFKRAKEIAGQYKIRAFQDYRELMSKVDAVSIAVPTSLHKQIALDFIEKGINILVEKPIAESIESAQEIIKAAKANNVVLMVGHIERFNPAVLKLREILRDGALGEIVTLMAKRVGPFPPQIKDVGVIIDLAVHDIDVMSFLLGEQVKEVYAKAGSAKNPLELEDYAVMVLTFESATGIVETNWLTPHKVRKLSVVGTEGIAELDYINQELTLYNHEWIRKAKIQKREPLRNEIEHFVECIEKGVEPIVSGRDGLHALKVAIMALESAKEGKIIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL40</accession>
    <name>F0LL40_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fucose_iso_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468243.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01973"/>
    <dbReference type="EnsemblBacteria" id="ADT84947">
        <property type="protein sequence ID" value="ADT84947"/>
        <property type="gene ID" value="TERMP_01973"/>
    </dbReference>
    <dbReference type="GeneID" id="10042288"/>
    <dbReference type="KEGG" id="tba:TERMP_01973"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1971"/>
    <dbReference type="eggNOG" id="arCOG01772">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039041_0_0_2"/>
    <dbReference type="OMA" id="PYTLGME"/>
    <dbReference type="OrthoDB" id="14936at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015888">
        <property type="entry name" value="Fuc_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02952">
        <property type="entry name" value="Fucose_iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucose_iso_C" evidence="2">
        <location>
            <begin position="347"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="492" mass="55245" checksum="A9A8E609CB1D2D1E" modified="2011-05-03" version="1">MIAVATFTDPRPTALSEERERALMEKHRALIEALEEFEILDVNAKLKKYEAFEKGENFGIDSKEEVLEAARIVNSKDVSGITLGLWHWTESNLVTLLAKETNKPLLLYADDDPAWAGTTCITSVGSSLWESAVNYYALHHTRLKGDVGKVKAWVRAVEAVSKLSKKSLLLWGAPYTLGMEHLMDDLPRLKRFIGDFLMLDQYLIVRKADEMLSDEKLRIKVEEFYDWLTSKAKVKFDNVMLTQEALRRQIAIYLAAKDIWEQYKSEVAGVSIKCQPELSEIYGVTACLIPALFPFSLDAKGEKPIIPATCEGDIKGTISSILLFYLSGKPPLFGDIKYVDDELVLIANCGASSLYYAKLSENPEENLSATTIQGQCQGKSGGALTYRTPKTTLTIARLIRIDGEYYLLYFLAEGVEITEEIEKKLKWGKQWPHTAVKNPLDKERFIAVMGANHLSAVPGDYTTELRFIAKLWGIKAVNLADKEQVEGLLEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL91</accession>
    <name>F0LL91_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467040.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83742">
        <property type="protein sequence ID" value="ADT83742"/>
        <property type="gene ID" value="TERMP_00765"/>
    </dbReference>
    <dbReference type="GeneID" id="10041083"/>
    <dbReference type="KEGG" id="tba:TERMP_00765"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.767"/>
    <dbReference type="eggNOG" id="arCOG03430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1521949_0_0_2"/>
    <dbReference type="OMA" id="GTYPYYV"/>
    <dbReference type="OrthoDB" id="84444at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="184" mass="21450" checksum="75B5D5C127484ACF" modified="2011-05-03" version="1">MNNAKKKGEQYFKKGKVLWVLKYKNKLYGKILGTYPYYVEVDIKSGKNRCTCPIGKDCKHVFAVLEAFENGRYFETSSHLVELSPQAVVDEIIFENPEIGKSIVLKELIYYVNHDESGSEAARLFRKALALLKREFSEEFYESLLIQFGEFKKVFYDYELIEELERELEELKKFMSNNPAGSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLB7</accession>
    <name>F0LLB7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="3">2.5.1.114</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA wyosine derivatives biosynthesis protein Taw2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">taw2</name>
        <name evidence="5" type="ordered locus">TERMP_00791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.114" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467066.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00791"/>
    <dbReference type="EnsemblBacteria" id="ADT83768">
        <property type="protein sequence ID" value="ADT83768"/>
        <property type="gene ID" value="TERMP_00791"/>
    </dbReference>
    <dbReference type="GeneID" id="10041109"/>
    <dbReference type="KEGG" id="tba:TERMP_00791"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.793"/>
    <dbReference type="eggNOG" id="arCOG00033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022610_0_2_2"/>
    <dbReference type="OMA" id="IHYHETV"/>
    <dbReference type="OrthoDB" id="55502at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102522">
        <property type="term" value="F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01922">
        <property type="entry name" value="TYW2_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030867">
        <property type="entry name" value="TYW2_archaea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="4">
        <location>
            <begin position="33"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="281" mass="32680" checksum="0DC3EB46F750AF67" modified="2011-05-03" version="1">MKKRKTQLIKPRIREILSKRLPKGLVDLLPKHWVQIGDVLILPLREELLPYKYEIAKVYAEVLGVKTVLRKGRILGEFREPHYEIIYGKDTVTVHKENGIFYKLDVARVMFSPANVKERVRMASIAKSNELVVDMFAGIGHLSLPIAKHCNAKVIAIEKNPYTFKFLVENIELNKVQDRMTAYNIDNRNFPGENIADRILMGYVIKTHEFIPKALEIAKDEAVIHYHNTVPEKLMPKEPFETFQRTAKEYGYEAELLESRIIKRYAPGVWHVVLDVKVYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLE7</accession>
    <name>F0LLE7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_02002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02002"/>
    <dbReference type="EnsemblBacteria" id="ADT84976">
        <property type="protein sequence ID" value="ADT84976"/>
        <property type="gene ID" value="TERMP_02002"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02002"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1999"/>
    <dbReference type="eggNOG" id="arCOG00683">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_16_1_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="145"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="263" mass="29613" checksum="D789FB18589ED8EB" modified="2011-05-03" version="1">MSFTVEEKLSKKGWIKVPREPKGSLTAGIDLGINNLMAVYVENGKSFLVNGRPLKSIAFYWQKKIANYQSKINKSGCKKSRKLRRMHEKAKLQAKHYINTAVRQTVEKLYHLGVKRIIIGYPKEIARNSNKGKKQNFILSHVWRFNTVIQRLKEVAEEYGIKVVLVDEAFTSQLCPLCGKPHDGARFVRGLFKCPTEGLVFNADLVGAFNILKKVVKTITPSLEGLKAFKVRGNGEKTLPEGLKTQFVLGLNETPQTSPSIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLH5</accession>
    <name>F0LLH5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GMP synthase [glutamine-hydrolyzing] subunit A</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">guaAA</name>
        <name evidence="5" type="ordered locus">TERMP_02030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468300.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02030"/>
    <dbReference type="MEROPS" id="C26.A31"/>
    <dbReference type="EnsemblBacteria" id="ADT85004">
        <property type="protein sequence ID" value="ADT85004"/>
        <property type="gene ID" value="TERMP_02030"/>
    </dbReference>
    <dbReference type="GeneID" id="26137638"/>
    <dbReference type="KEGG" id="tba:TERMP_02030"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2027"/>
    <dbReference type="eggNOG" id="arCOG00087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_4_2"/>
    <dbReference type="OMA" id="GPDMDRI"/>
    <dbReference type="OrthoDB" id="79931at2157"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01510">
        <property type="entry name" value="GMP_synthase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023686">
        <property type="entry name" value="GMP_synthase_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1 3" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT85004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="188" mass="21630" checksum="4ABD61E0C9897C2F" modified="2011-05-03" version="1">MIIIMDNHGQYVHRIWRTLRYLDVEAKIIPNTTPLEEIRAMKPKGIIFSGGPSLERTGNCEAILKNYEDFNVPILGICLGHQLIAKYFGGKVGRGEKAEYSLVEVEILEENDIFKGLPRRLKVWESHMDEVKELPKDFELLARSEFCEVEAMKHKKLPVYGVQFHPEVAHTEKGSEIYRNFAELCGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLI2</accession>
    <name>F0LLI2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formate-dependent phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="3">6.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-phosphoribosylglycinamide transformylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Formate-dependent GAR transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">GAR transformylase 2</fullName>
            <shortName evidence="3">GART 2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Non-folate glycinamide ribonucleotide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purT</name>
        <name evidence="6" type="ordered locus">TERMP_02037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24829"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.21" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468307.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02037"/>
    <dbReference type="EnsemblBacteria" id="ADT85011">
        <property type="protein sequence ID" value="ADT85011"/>
        <property type="gene ID" value="TERMP_02037"/>
    </dbReference>
    <dbReference type="GeneID" id="26137649"/>
    <dbReference type="KEGG" id="tba:TERMP_02037"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2034"/>
    <dbReference type="eggNOG" id="arCOG01598">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_1_3_2"/>
    <dbReference type="OMA" id="GMVTMIT"/>
    <dbReference type="OrthoDB" id="57699at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043815">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase 2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01643">
        <property type="entry name" value="PurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005862">
        <property type="entry name" value="PurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01142">
        <property type="entry name" value="purT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="123"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="3">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="3">
        <location>
            <begin position="382"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT85011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="429" mass="47986" checksum="A7541559491F5964" modified="2011-05-03" version="1">MAEIRDELGTPLTDSAVKILLLGSGELGKEIAIEAQRLGVEVIAVDRYPNAPAMQVAHKSYVGNMKDKDFLWSIVEREKPDAIIPEIEAINLDALFEFEKEGYFVVPNARATWIAMHRERTRETLAKEAKVPTSRYRYATTLDELYDACEKIGYPCHTKAIMSSSGKGSYFVKGPEDVPKAWEEAKKKARGSADKIIVEEHIDFEVEITELAVRHLDENGKVVTTFPKPVGHYQIKGDYHSSWQPAEISEKAERKVYEIAKKITDVLGGLGLFGVEMFVKGDKVWANEVSPRPHDTGMATLASHPTGFSEFGLHVRAVLGLPIPAVEENGIRKFPILTPAATHVILANQEGYAPKFRGLFKALRIPNTTVRLFGKPSAYKGRRLGVALAWDRDVQAAKRKAEQVAHMIELKTRSGEWQSQEFIKEKHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLJ1</accession>
    <name>F0LLJ1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT85020">
        <property type="protein sequence ID" value="ADT85020"/>
        <property type="gene ID" value="TERMP_02046"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02046"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2043"/>
    <dbReference type="eggNOG" id="arCOG11085">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2857300_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="64" mass="7332" checksum="17E8A260900F3520" modified="2011-05-03" version="1">MRGKLLSEAAKLNGASENARLEIERLLKELEGLYKEISMSEKVSEEQIEAVLSYREKLFKIVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLJ3</accession>
    <name>F0LLJ3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Elongation factor 1-beta</fullName>
            <shortName evidence="7">EF-1-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">aEF-1beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ef1b</name>
        <name evidence="9" type="ordered locus">TERMP_02048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468318.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02048"/>
    <dbReference type="EnsemblBacteria" id="ADT85022">
        <property type="protein sequence ID" value="ADT85022"/>
        <property type="gene ID" value="TERMP_02048"/>
    </dbReference>
    <dbReference type="GeneID" id="26137659"/>
    <dbReference type="KEGG" id="tba:TERMP_02048"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2045"/>
    <dbReference type="eggNOG" id="arCOG01988">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165896_0_0_2"/>
    <dbReference type="OMA" id="VMPNSPE"/>
    <dbReference type="OrthoDB" id="124073at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00043">
        <property type="entry name" value="EF1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004542">
        <property type="entry name" value="Transl_elong_EF1B_B_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39647">
        <property type="entry name" value="PTHR39647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006521">
        <property type="entry name" value="Transl_elong_EF1B_B_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="SSF54984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00489">
        <property type="entry name" value="aEF-1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF1_GNE" evidence="8">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT85022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="91" mass="10191" checksum="F70AE2D7E1A564C3" modified="2011-05-03" version="1">MSDFNIVGVIKVMPTSPEVDLDKLEENIKKAIPEKYGFVKIEREPIAFGLVALKVYVLAKDEEGYSLDEVADAFRKVEDVESAEVESVSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLJ5</accession>
    <name>F0LLJ5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_02050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms a Heterooligomeric complex of two stacked eight-membered rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468320.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02050"/>
    <dbReference type="EnsemblBacteria" id="ADT85024">
        <property type="protein sequence ID" value="ADT85024"/>
        <property type="gene ID" value="TERMP_02050"/>
    </dbReference>
    <dbReference type="GeneID" id="10042365"/>
    <dbReference type="KEGG" id="tba:TERMP_02050"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2047"/>
    <dbReference type="eggNOG" id="arCOG01257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="OrthoDB" id="11742at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT85024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="547" mass="59156" checksum="6D8E6151B07E82BD" modified="2011-05-03" version="1">MAQLAGQPILILPEGTQRYVGKDAQRLNILAARIVAETVRTTLGPKGMDKMLVDSLGDIVITNDGATILDEMDIQHPAAKMMVEVAKTQDKEAGDGTTTAVVIAGELLRKAEELLDQNIHPSIIVKGYTMAAEKAQEILDSIAKDVDVNDEETLLKAAITAITGKAAEEEREYLAKLAVEAVKQVAEKVGDKYHVDIDNIKLEKKEGGSVKDTKLIKGVVIDKERVHPGMPKRVEGAKIALINDAIEVKETETDAEIRITSPEQLQAFLEQEERMLKEMVDKIVATGANVVFCQKGIDDLAQHYLAKAGILAVRRVKKSDMEKLAKATGAKIVTNIRDLTPDDLGYAEVVEERKVAGENMIFVEGCKNPKAVTILIRGGTEHVVDEVERAMEDAIKVVKDIVEDGKIVAGGGASEIELSVKLDEYAKEVGGKEQLAIEAFAEALKVIPRTLAENAGLDPIETLVKVIAAHKEKGPTVGVDVFAGEPADMMERGVIEPVRVKKQAIKSASEAAIMILRIDDVIAAQKLEKEKEGEKGGGSEDFSSDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLL7</accession>
    <name>F0LLL7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Thymidine kinase</fullName>
            <ecNumber evidence="2 8">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tdk</name>
        <name evidence="10" type="ordered locus">TERMP_00817</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467092.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00817"/>
    <dbReference type="EnsemblBacteria" id="ADT83794">
        <property type="protein sequence ID" value="ADT83794"/>
        <property type="gene ID" value="TERMP_00817"/>
    </dbReference>
    <dbReference type="GeneID" id="10041135"/>
    <dbReference type="KEGG" id="tba:TERMP_00817"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.819"/>
    <dbReference type="eggNOG" id="arCOG04798">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064400_3_0_2"/>
    <dbReference type="OMA" id="ENTVNHK"/>
    <dbReference type="OrthoDB" id="88449at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020633">
        <property type="entry name" value="Thymidine_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00603">
        <property type="entry name" value="TK_CELLULAR_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="90"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="147"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        <location>
            <position position="150"/>
        </location>
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        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="192" mass="21478" checksum="3CC8CE30B0A9A922" modified="2011-05-03" version="1">MHPEGFLEVITGPMFAGKTTELIKRIERQIFAKRKAALFKPSIDNRYSESEVVAHNGLRYEAYVIPTTEEGVKMIYEITERERLEVIGVDEVQFFPFSIVETLNKLADEGVYVIAAGLNLDFKGDPFPVTKELLVRADNIVYLTAICTVCGAPATRSQRLINGKPAPRDSPVILVGGLESYEARCRKHHVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
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        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
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            <taxon>Euryarchaeota</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="180" mass="19901" checksum="119E5409A134CC12" modified="2011-05-03" version="1">MKELLVLFISAFVLISGCVGHGDDRMSLKVTSVFKNGEPIPSRYTCEGADISPPLRVEGLSDKAVSIAIIVDDPDAPIGTFVHWVAWNIPPVNEIPENIPKKGVVESPIHVVQGRNDFGRIGYNGPCPPRGHGIHHYHFKIYVLDTQLNLKPGATKRDLEKAMKGHIIQYGELIGIYERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="92"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="161" mass="18020" checksum="E24D8DDF8976BD3E" modified="2011-05-03" version="1">MEIKAVLDLRGLNPPEPAVRIVEALKDLKEGEGIEAIGDKPFKGILPKLEEASYRHELKKAGDAYILRIWNDGSAGEISGLDDVECAKEIEINENTNVGMLIERYPEALEVLIEYGFTPLKDETLRKTLAKTITLKEAKELGNLSDEKFGELLEKLKKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLR5</accession>
    <name>F0LLR5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Na(+) H(+) antiporter subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00865"/>
    <dbReference type="EnsemblBacteria" id="ADT83842">
        <property type="protein sequence ID" value="ADT83842"/>
        <property type="gene ID" value="TERMP_00865"/>
    </dbReference>
    <dbReference type="GeneID" id="26136314"/>
    <dbReference type="KEGG" id="tba:TERMP_00865"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.868"/>
    <dbReference type="eggNOG" id="arCOG03099">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086615_2_2_2"/>
    <dbReference type="OMA" id="PYFLWAM"/>
    <dbReference type="OrthoDB" id="78706at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34584">
        <property type="entry name" value="PTHR34584"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019239">
        <property type="entry name" value="MrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="168" mass="19052" checksum="B7B79EDC20434099" modified="2011-05-03" version="1">MEEASRISRYLYTVIVLFVIWLFLTSSLDPQELIIGALFSLIVAALTYEVFTEKGLANLHPKRIAYAVAYVPYFLWAMIMANLDVAYRVLHPKRPINPGIVECKTVLRNNVGKLTLANSITLTPGTITLDVKGDRYFIHWIDVKDATVEGASENITKPFEKFLKVIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLX6</accession>
    <name>F0LLX6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468371.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02101"/>
    <dbReference type="EnsemblBacteria" id="ADT85075">
        <property type="protein sequence ID" value="ADT85075"/>
        <property type="gene ID" value="TERMP_02101"/>
    </dbReference>
    <dbReference type="GeneID" id="25394645"/>
    <dbReference type="KEGG" id="tba:TERMP_02101"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2098"/>
    <dbReference type="eggNOG" id="arCOG07126">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444718_0_0_2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="188" mass="20892" checksum="F625E36EC8272BDE" modified="2011-05-03" version="1">MIWLIASLIAGIAFRAWAVILLVVAYLASRKSRDSALLIYFFYGILLVSEVHVGDFISYESLKALAIIVPSIAILREILSGTELKVKFTPLQLIGIFVLAAGLLYGYLLPWGTALLIAGEEGLSFRALRDVAAGVLVLFSMLWIVKAKYPYLYTPENQVAIAAGFIILLILKEIRNLKKVEFKLRMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLY2</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02107"/>
    <dbReference type="EnsemblBacteria" id="ADT85081">
        <property type="protein sequence ID" value="ADT85081"/>
        <property type="gene ID" value="TERMP_02107"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02107"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2104"/>
    <dbReference type="HOGENOM" id="CLU_3302930_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="39" mass="4451" checksum="A9ACA4D9B572A87C" modified="2011-05-03" version="1">MISIVEALTGNEEYKGKGRMRQYGMKSSSVIYIQHGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM10</accession>
    <name>F0LM10_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine-guanine phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">TERMP_02135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02135"/>
    <dbReference type="EnsemblBacteria" id="ADT85109">
        <property type="protein sequence ID" value="ADT85109"/>
        <property type="gene ID" value="TERMP_02135"/>
    </dbReference>
    <dbReference type="GeneID" id="10042450"/>
    <dbReference type="KEGG" id="tba:TERMP_02135"/>
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    <dbReference type="eggNOG" id="arCOG00040">
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    </dbReference>
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    <dbReference type="OMA" id="MPVMLAP"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="153" mass="17492" checksum="05D9F207597FDF9C" modified="2011-05-03" version="1">MDKVYLTWWQVDRAIFSLADKLREYKPDVIVGIARGGLIPAVRLSHILGDIELKVIDVKFYTDISEHAEMPKVVIPIHGDLKGKRVVIVDDVSDTGKTLEVVINEVKKLGAEEIKVACLAMKPWTSVVPDFYVFRTDKWIVFPWEEFPVVVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM12</accession>
    <name>F0LM12_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02137"/>
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    </dbReference>
    <dbReference type="GeneID" id="10042452"/>
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    <dbReference type="eggNOG" id="arCOG03167">
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    <dbReference type="OMA" id="IGSHNTV"/>
    <dbReference type="OrthoDB" id="21850at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF13173">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="40"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="429" mass="50286" checksum="840D9E52189A18FA" modified="2011-05-03" version="1">MEELIGFQNPWWRDKKAIYEDEKVKEALSKRNPIGYTFENRNKIIVGPRQVGKTTYLKLTILDLIERGTNPRSILYFSCDLLKDYRDIVEILKFFSRMQRGKKFVFLDEVTFVEGWERAIKFFLDSPLKKDTTLYITGSSSLGLKKESFPGRPIKVEEFLPLSFKKVVELLNPKIKRELEKITLETSPKILYENALELYPHMDELFEAFYFYLSSGGYPKSIFELLESGEISPDTYEMIYNATIFDVTKLGRSERIALSIILGILKRYGEKFSLNALSKEMEIGSHVTVREYLEIFEELFIGRNYFQTKPNLMTPLFKKERKFYFLDPLILETFSRKFGIEVEIAKKVEGIVGEHIKRNFDTYFFHNAKEVDFVTKDFGVEVKWQNKVKPSDFPRVGIKNKILLSKGKLDFIEERNLAIIPVPLFLVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMB4</accession>
    <name>F0LMB4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02163"/>
    <dbReference type="eggNOG" id="arCOG05782">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_219273_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="39" mass="4559" checksum="480119FB83C73535" modified="2011-05-03" version="1">MVKMKASALAFLIFAWGSIFFMMYWSITKLLKAEQQQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMD1</accession>
    <name>F0LMD1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative stomatin/prohibitin-family membrane protease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_02180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468450.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02180"/>
    <dbReference type="EnsemblBacteria" id="ADT85154">
        <property type="protein sequence ID" value="ADT85154"/>
        <property type="gene ID" value="TERMP_02180"/>
    </dbReference>
    <dbReference type="GeneID" id="10042495"/>
    <dbReference type="KEGG" id="tba:TERMP_02180"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2175"/>
    <dbReference type="eggNOG" id="arCOG01915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_2_2_2"/>
    <dbReference type="OMA" id="AMTQQMK"/>
    <dbReference type="OrthoDB" id="49614at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="20"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT85154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="313" mass="35497" checksum="A8001815D0016312" modified="2011-05-03" version="1">MPATFALVILGVFLLLMLVLSVKVIRPYQKGLVERLGKFNRILEPGIHFIIPFMERVRIIDMREHVIDVPPQEVICKDNVVVTVDAVVYYQVIDPVKAAYNVSDFLLAIIKLAQTNLRAIIGEMELDETLSGRDIINARLREELDKITDRWGVKITRVEIQRIDPPRDIQEAMAKQMTAEREKRAMILIAEGKKESAIKQAEGEKQARILRAEGIKQEQILIAEGQAEAIKKVLEALKLADEKYLTLQYIEKLPELAKYGNLIVPYDTEALIGLLRVLQKVSKTKLPEPKENPPEGSSKNSPAETENDKMRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LME4</accession>
    <name>F0LME4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion_trans_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_02193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02193"/>
    <dbReference type="EnsemblBacteria" id="ADT85167">
        <property type="protein sequence ID" value="ADT85167"/>
        <property type="gene ID" value="TERMP_02193"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02193"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2188"/>
    <dbReference type="eggNOG" id="arCOG03127">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044435_0_0_2"/>
    <dbReference type="OMA" id="DLTCKYG"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="PTHR11537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="8">
        <location>
            <begin position="402"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT85167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="483" mass="56185" checksum="FDD3694E0FFB40FF" modified="2011-05-03" version="1">MMCEYVYENGQKCRTKPLKGSNFCSLHIPYEEGELLYGEKIKEIKKKAFLKKIRRGITYFEGVYLYDVRISDLKIEQTIVFKNSKIKTLIVDSSEIGGLTIYGSSIERIIIVKTTLKTLMITRSNIFGFNALEVNFSGSIYLKNSEIRYIMMNSFHYTKGEEKPSEEEYGERSKAYGRVELTNLSGVRRIGINSRYPLLRQILEEHGIKVSDISRKHAKAEILAISGVQFDENPRFKRQVRILLRAFNGQLLMENLEIPGHVQVTQSKIKLPEFVHVRILNNIIFRKVRFYSDTTWNLTVLPNLVAELDVEGFMLLEDCQFNNPYIEEIFYRLARTSWERGGDKDKADEYYYKEMVAKRKQRMTAYRRGKRKIFLIESYVEWLLADLTCKYGTTWKRPIVIWIITVNIIFPILFYITKSVEGSGVPLKSFLDYVYFSIVTATTLGYGDLHPVGIGRVLASGEAIFGMFMWAVLLTVFARKYMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMF2</accession>
    <name>F0LMF2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468471.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02201"/>
    <dbReference type="EnsemblBacteria" id="ADT85175">
        <property type="protein sequence ID" value="ADT85175"/>
        <property type="gene ID" value="TERMP_02201"/>
    </dbReference>
    <dbReference type="GeneID" id="10042516"/>
    <dbReference type="KEGG" id="tba:TERMP_02201"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2196"/>
    <dbReference type="eggNOG" id="arCOG00360">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048086_2_1_2"/>
    <dbReference type="OMA" id="RMANIML"/>
    <dbReference type="OrthoDB" id="68115at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038880">
        <property type="entry name" value="MJ0871-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38139">
        <property type="entry name" value="PTHR38139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="314" mass="34237" checksum="D0B3FB805B5EEE1C" modified="2011-05-03" version="1">MELLITSAGIAFNFLKRSVPGLLIGIFIAELLIEKGAVEKVSFIGKPFVKLSNLPGECALTFATAFLNTRAANAMLVDFYREGKIGRRELYIASLMNAFPAMVRHWNSLIPVLLATLGKLGLLYFGILVFIGLIQTTVFAVAGKILIKNPREISNPQKQMRKKKPFKEVLRNALTKTKKTSLPILKTMVIVAYITALLIAVGFFNHLSDLVRSFAQSLPFSPEELSVALSAMAGSIAAYTLGANLLKAGLISEKALIRALLLGSIFANITFLRVLIPYYVGLYGPKDGTKLMLISMTTRSVIILCIIAVMGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMG3</accession>
    <name>F0LMG3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467240.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00966"/>
    <dbReference type="EnsemblBacteria" id="ADT83942">
        <property type="protein sequence ID" value="ADT83942"/>
        <property type="gene ID" value="TERMP_00966"/>
    </dbReference>
    <dbReference type="GeneID" id="10041283"/>
    <dbReference type="KEGG" id="tba:TERMP_00966"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.969"/>
    <dbReference type="eggNOG" id="arCOG05412">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_2"/>
    <dbReference type="OMA" id="DWVYVVP"/>
    <dbReference type="OrthoDB" id="23256at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="416" mass="49029" checksum="BC994C527E0455AD" modified="2011-05-03" version="1">MLKFPDHFIFGTATSSYQIEGDNIWSDWWYWAEKGRLPKAGKACNHWELYKEDIELMASLNYPAYRLSVEWARIFPEEGKLNESALERYQDIIDLLNKKGITPMLTVHHFTLPMWFALKGGFEKDENLKYWEEYVSVIAELKGVELVATFNEPMVYVVAGYLMGMWPPFKKNPPKAGKVAANLINAHAIAYEILHGRFKVGIVKNYQHFIPATNSKRDKEARDRVDYLFNWAFIDGIFHGSYESFMKKYKVNESDLDFIGINYYNIQKVKKSWNPLNPFIVEDASVSRKTDMGWSVYPKGIYEGIKAFSRYERPMYITENGIATLDDGWRIEFIIQHLQYVHKAIREDLDINGYFYWSLMDNYEWAEGFRPRFGLVEIDYETFERKPRKSAYVYGEIAKRKEISNELLEKYGLREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMH2</accession>
    <name>F0LMH2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sarcosine oxidase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="protein sequence ID" value="ADT83951"/>
        <property type="gene ID" value="TERMP_00975"/>
    </dbReference>
    <dbReference type="GeneID" id="10041292"/>
    <dbReference type="KEGG" id="tba:TERMP_00975"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.978"/>
    <dbReference type="eggNOG" id="arCOG01294">
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    <dbReference type="OrthoDB" id="48488at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.440">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
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        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
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        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pyr_redox_2"/>
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    </dbReference>
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        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="478" mass="52119" checksum="F13131BE3B4C99A4" modified="2011-05-03" version="1">MRLTEHPVLDFQKKRGRKITIYFEGQPVEAYEGETIVMALHAAGIRVLGYSVHKHRPRGLFCAIGKCSSCLMTVNGIPNVRTCITLVEEGMDIRMQWEKPTLPRDAKPPEWKEAEKVSGDIVIIGGGPAGLMAAVNAADAGAKVILLDENPMLGGQLVKQTHKFFGKREQFAGVRGIKIAEILEEEVRKRENIEIFLETSAIMLLQDGDEKLVVGVRKNKELIEFRGKAVIVATGAMEKMIPFEGNDLPGVYGAGAIQTLMNTYGVKPGDRVLIVGAGNVGLILAYQLIQAGVEVKAIVEAMPKIGGYFVHAAKVRRLGVPILTRHTILRAEGKEKVERAVVAQIDEKWRPIPGTEKVFDVDVIALAVGLRPSIELLHQVGCQIKYVPELGGHVVIRDSRMETTVKGIFVAGDSAGIEEATTAMLEGKIAGIAAALEIGIAPPEWLKEIEKAQKELDEFRAGPFGRKVLEGIKKVVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMJ6</accession>
    <name>F0LMJ6_THEBM</name>
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        <submittedName>
            <fullName evidence="5">Inosine-5'-monophosphate dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ordered locus">TERMP_00999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00999"/>
    <dbReference type="EnsemblBacteria" id="ADT83975">
        <property type="protein sequence ID" value="ADT83975"/>
        <property type="gene ID" value="TERMP_00999"/>
    </dbReference>
    <dbReference type="GeneID" id="26136448"/>
    <dbReference type="KEGG" id="tba:TERMP_00999"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1002"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01863">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_7_0_2"/>
    <dbReference type="OMA" id="YGICELC"/>
    <dbReference type="OrthoDB" id="83765at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044065">
        <property type="entry name" value="ACP_MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51901">
        <property type="entry name" value="ACP_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="ACP-type MB" evidence="4">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="179" mass="20104" checksum="9822A07F445FBA27" modified="2011-05-03" version="1">MMPKITVEQVLKRKAVVVKPEDTVDKVAKILAKNKVSSAVIVENDEIIGIVTDRDILDKIVAKGKNPKHIKVREIMTKNPVRIEYDYDIQDAIELMMDKGVRRILVTKLGKPIGFVTAADLLAALAMYNSEEQEVESVESETEVYGICEVCGQYGPLYRVYIGGQEKWVCESCKDSIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMP5</accession>
    <name>F0LMP5_THEBM</name>
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        <submittedName>
            <fullName evidence="2">HEPN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01048</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01048"/>
    <dbReference type="EnsemblBacteria" id="ADT84024">
        <property type="protein sequence ID" value="ADT84024"/>
        <property type="gene ID" value="TERMP_01048"/>
    </dbReference>
    <dbReference type="GeneID" id="26136500"/>
    <dbReference type="KEGG" id="tba:TERMP_01048"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1051"/>
    <dbReference type="eggNOG" id="arCOG01191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123170_0_1_2"/>
    <dbReference type="OMA" id="CYHCQQA"/>
    <dbReference type="OrthoDB" id="111480at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="126" mass="14956" checksum="86E73C3E79D08593" modified="2011-05-03" version="1">MKTDVKDWIRKADEDLKASEILLEQNLYALSCFHAQQAVEKYLKAFLLEHDREISKTHNIKFLLNQCCEIDKSFRELFKSGVHYLTEYAVEVRYPGIYEPDREEAKDALRLAKVVKEFVLRKLMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMQ3</accession>
    <name>F0LMQ3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01056"/>
    <dbReference type="EnsemblBacteria" id="ADT84032">
        <property type="protein sequence ID" value="ADT84032"/>
        <property type="gene ID" value="TERMP_01056"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01056"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1059"/>
    <dbReference type="eggNOG" id="arCOG03799">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1727324_0_0_2"/>
    <dbReference type="OMA" id="LEYLMIE"/>
    <dbReference type="OrthoDB" id="103362at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008553">
        <property type="entry name" value="DUF835"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05763">
        <property type="entry name" value="DUF835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF835" evidence="1">
        <location>
            <begin position="30"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="151" mass="17406" checksum="AADCBAE0813783C1" modified="2011-05-03" version="1">MFKMLKDMMSANVKFEGEELPFQVVHYSKMRNLLKKFSHKKKILITRTPPTVNDNATFYIWISKIDHPNAVSPTDLYVIEQKVWEIIKKESPIIVLDAFEYLMMEQGLEATLRFTGKLRDIALLNNSGFIVSISEGLDDKTVALLKRIVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMV6</accession>
    <name>F0LMV6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT84085">
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    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01109"/>
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    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="176" mass="20825" checksum="B0FAC286215846CE" modified="2011-05-03" version="1">MGSEMKKSGSFILMVLLLISVFSTYSWWKAEKEKKEVLAEFYWKFQTSSIELSYMGGTFEYLLRNNASYEVLLLYLDIYYFHVRNLYWTFGILAAYTNEQKFRKLNAALVDLSVALNHMRKPPGELQEDLKKNLETLKRFDDLFKELSKYNTPWEIPDELADEFFKLSEELMKNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN03</accession>
    <name>F0LN03_THEBM</name>
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        <recommendedName>
            <fullName evidence="1">V4R domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ordered locus">TERMP_01156</name>
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    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01156"/>
    <dbReference type="EnsemblBacteria" id="ADT84132">
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    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01156"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="121"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="183" mass="21455" checksum="0514F607A5E2E742" modified="2011-05-03" version="1">MEDISVLIEKWRKIYKEEVKSKRKHREEIRLTPENYFNVVRPFFVKISPEDREYVRTFRMVSYGMLEYSPSLRTLILRGAGYNLARRLIETGEIRSIDDLPKVFLNQKIGLLDIVDESFSKMKVNIYECISCYRAPPIGRTLCDFEAGLIQGVMEELVGKNVTREIYCWGLGNSFCGFEVIFE</sequence>
</entry>
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        </submittedName>
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        <lineage>
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            <taxon>Euryarchaeota</taxon>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
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        </source>
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02216"/>
    <dbReference type="EnsemblBacteria" id="ADT85189">
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    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02216"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2210"/>
    <dbReference type="HOGENOM" id="CLU_3113262_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="50" mass="5880" checksum="73AC9333E053C35E" modified="2011-05-03" version="1">MIYLHPLRMEVSVLKRILSERNIITIMGNRTTGDSSQLAYIQYHFGDIKR</sequence>
</entry>
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    <accession>F0LN56</accession>
    <name>F0LN56_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Thermococcus</taxon>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
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                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
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        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT85195">
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    </dbReference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3075545_0_0_2"/>
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        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
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        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
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        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="ADT85195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="52" mass="5883" checksum="629D90C245131692" modified="2011-05-03" version="1">MSQGETKEEALRNIKEAIGLYLEVLEKDFEKITLHLIGGGNFALRGKFKKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN97</accession>
    <name>F0LN97_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
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    </organism>
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        <name>pTBMP1</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
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                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
            <plasmid evidence="2 3">pTBMP1</plasmid>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ADT85236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="tba:TERMP_02263"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2056168_0_0_2"/>
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        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CopG"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="119" mass="13805" checksum="384B704D6A1B9F00" modified="2011-05-03" version="1">MPSIFKKLSISLPPELVELLDVLVEKGLYATRSEIIREALYLLLWDLVDSVEIYEKVAKEASEKGVPLDEYIDELIEKAESSDVVELIRLSGLSLDEIRILKKKIKKIQRKLERNLYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGX7</accession>
    <name>F0LGX7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagella protein FlaH-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">TERMP_01209</name>
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    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
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                <person name="Vannier P."/>
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                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01209"/>
    <dbReference type="EnsemblBacteria" id="ADT84185">
        <property type="protein sequence ID" value="ADT84185"/>
        <property type="gene ID" value="TERMP_01209"/>
    </dbReference>
    <dbReference type="GeneID" id="10041526"/>
    <dbReference type="KEGG" id="tba:TERMP_01209"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1211"/>
    <dbReference type="eggNOG" id="arCOG04148">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094838_0_0_2"/>
    <dbReference type="OMA" id="IVKYNNA"/>
    <dbReference type="OrthoDB" id="60868at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="24"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="231" mass="26048" checksum="2D929B49FF27EC01" modified="2011-05-03" version="1">MGTLLKIQIPNDELHRRLGGGIPSGSIMLIEGDRGTGKSIFSQRLLYGFLRNNHTASYISSQYTTPEFINQMESLGYSIITDLIRRRLIFVSVYPLLVGVSKREKFLTRFLSESRIWDRDVVIIDSISSLLPTTLDEDELRRLADHIKKLSSLGKVIMLTVNPNDIDGDILRILEEISTILVRLQVKVFGGDLKNSATIVKYNNAMGIFQKIIPFRVEPRVGFIVEIAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGX9</accession>
    <name>F0LGX9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flagella protein FlaJ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467485.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01211"/>
    <dbReference type="EnsemblBacteria" id="ADT84187">
        <property type="protein sequence ID" value="ADT84187"/>
        <property type="gene ID" value="TERMP_01211"/>
    </dbReference>
    <dbReference type="GeneID" id="10041528"/>
    <dbReference type="KEGG" id="tba:TERMP_01211"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1213"/>
    <dbReference type="eggNOG" id="arCOG01809">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_479528_0_0_2"/>
    <dbReference type="OMA" id="DRLWHTG"/>
    <dbReference type="OrthoDB" id="8691at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="88"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="337"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="569" mass="63765" checksum="B8C2B2CEF0C6FEBF" modified="2011-05-03" version="1">MGRKKAGIFTQSDLTIRSYLKAVLGPSIAISVVLFIIISIAPRFVGIPHMVSIALYAIPLLPLIYAVSYPYAKASSKKVKINSKIPYFATYFAVLSTSDVSRSDLIWNLSTEQILEPIATDMKKVYYLIAKLHRGMPEALRFLAKRTPSKVFSDFLERLAYSLDSGVELKDYLLQEQKTVMDDYETFYENALYDLDVFKEIYSSLIISVVFMVTFVIIGPIITGQDIVSLSIFMFVLILATEIGVLVVIKHKMPEDKIWSETAMIPIRKSKIIKAAIISIIGMIIMAILYIFVIKPRFDVPLLMSIAVVLTPLAYVGKVIGNEEESIIIKDENFPAFIRSLSSSLAASGASLHLVLKYLSSHDFGTLTHDIRNLYRRVAMRINDSRAWDYFVSDTGSWLISIFSEIFKKSIKLGAEPDYVGMVISRNFERLVRLRRKRQQNVASFKGVIYGITGAFAFSVAAAFQVAVYMNYLFSNIQVSGEFLQSIIFVPSSSGLRLTSYILVAILLLHAFLSSFSIKLADGGHLGISIYHFVILTWIAALSMYIGELAMKKMMTFAGILWPLLGVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LGY6</accession>
    <name>F0LGY6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467492.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01218"/>
    <dbReference type="EnsemblBacteria" id="ADT84194">
        <property type="protein sequence ID" value="ADT84194"/>
        <property type="gene ID" value="TERMP_01218"/>
    </dbReference>
    <dbReference type="GeneID" id="10041535"/>
    <dbReference type="KEGG" id="tba:TERMP_01218"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1220"/>
    <dbReference type="eggNOG" id="arCOG02300">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_691908_0_0_2"/>
    <dbReference type="OMA" id="WKDIIPS"/>
    <dbReference type="OrthoDB" id="62175at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009639">
        <property type="entry name" value="Pept_A24A_C_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06819">
        <property type="entry name" value="Arc_PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="2">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Arc_PepC" evidence="3">
        <location>
            <begin position="231"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="375" mass="42217" checksum="9021EBB6B21A40B8" modified="2011-05-03" version="1">MQFLLIALGVIMGVLTSYTDIKTGFIDDKHIFPFVALGIVYYVYSGLKVGDLFYASSGLIGLGAGFLIGYLMYLLGGWASGDVIILAGYSALFPYASEYAKIKAPYAVYYPLHALTLFFNSIIGVFPFLFIYALASLIVKKKIDRLKAVFTENVVLTVELTLWITVSLGFFVVLQYYLGVALHPLVRWIGTLVLVGILGKYKKVGNTIGVASLAIFTYITGSVFLRSFVKLLVIFYIFKVFFSLTKVLREEILIERKPIEELKEWDILGEWIYEKNGEILRDRESFTDKFKKALVAGNLSLLKLSYENVIASPTAEGLTKEQIEKLKKLVEEGRLENEFIVRKAMPFAPALFLGFLISVFYGDLFWLLLQKMSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH41</accession>
    <name>F0LH41_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase ISC1173</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467547.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01273"/>
    <dbReference type="EnsemblBacteria" id="ADT84249">
        <property type="protein sequence ID" value="ADT84249"/>
        <property type="gene ID" value="TERMP_01273"/>
    </dbReference>
    <dbReference type="GeneID" id="10041590"/>
    <dbReference type="KEGG" id="tba:TERMP_01273"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1276"/>
    <dbReference type="eggNOG" id="arCOG10271">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1709229_0_0_2"/>
    <dbReference type="OMA" id="EMTEQTI"/>
    <dbReference type="OrthoDB" id="89262at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="153" mass="17501" checksum="06C4C7F8B1691513" modified="2011-05-03" version="1">MKKMFLVFLAIVLMMYFYPLSILPLLILAREWGEFREEWMKSALFIGASIPLYGAKIFLGISGWAKILGISTLSVSPFIRWAVYLLFTTLQTLAIYYIYCVSKSIGKYGRTGGLAMLIAVPLHLLSLKLYFILTWIGLILFLLSLKKKNEVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH45</accession>
    <name>F0LH45_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466305.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00029"/>
    <dbReference type="EnsemblBacteria" id="ADT83007">
        <property type="protein sequence ID" value="ADT83007"/>
        <property type="gene ID" value="TERMP_00029"/>
    </dbReference>
    <dbReference type="GeneID" id="10040348"/>
    <dbReference type="KEGG" id="tba:TERMP_00029"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.28"/>
    <dbReference type="eggNOG" id="arCOG05811">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1682792_0_0_2"/>
    <dbReference type="OMA" id="FWTEING"/>
    <dbReference type="OrthoDB" id="82948at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="156" mass="17394" checksum="C2813717B04D8395" modified="2011-05-03" version="1">MKVEGFVASLKNAETIAQLFEILEKKGAPVIELDGENFLLVVEGDFEGVKFWTEINGKKANMALGDAMLNSASFPFKCKKPYTGGNAIFVKMSDIESEEFLVAYKSEGLGLYFKVKEGKAEKISPADYERLIPEMPEFKVKSFSEEQMDMMGAFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH57</accession>
    <name>F0LH57_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA small subunit methyltransferase Nep1</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">16S rRNA (pseudouridine-N1-)-methyltransferase Nep1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nep1</name>
        <name evidence="6" type="ordered locus">TERMP_00041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:46696"/>
            <dbReference type="Rhea" id="RHEA-COMP:11633"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466317.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00041"/>
    <dbReference type="EnsemblBacteria" id="ADT83019">
        <property type="protein sequence ID" value="ADT83019"/>
        <property type="gene ID" value="TERMP_00041"/>
    </dbReference>
    <dbReference type="GeneID" id="10040360"/>
    <dbReference type="KEGG" id="tba:TERMP_00041"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.42"/>
    <dbReference type="eggNOG" id="arCOG04122">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055846_1_3_2"/>
    <dbReference type="OMA" id="VYVHTRN"/>
    <dbReference type="OrthoDB" id="72065at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00554">
        <property type="entry name" value="NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023503">
        <property type="entry name" value="Ribosome_NEP1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="PTHR12636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="196"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes Arg-xx" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="219" mass="25281" checksum="66CA4039AD0C5495" modified="2011-05-03" version="1">MLHLIIADSEVEPVPKNILEHPAVVNYAKRRGKKPEEVILDSTYHHAALKKLEDGNRRGRPDIVHFCLINALESILNKEGMLRVYVHTRNDKVIYIKPETRIPRNYNRFVGLMESLFKNKVVPPDLELLKLEEKTLNQLLEEIKPDAVFIMHEQGEFMKPKDFGQLLKQFKEPAVIVGGFPHGDFKSKVDGVKISLYKEPLMAWTIVNEVIVNYENAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH67</accession>
    <name>F0LH67_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466327.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00051"/>
    <dbReference type="EnsemblBacteria" id="ADT83029">
        <property type="protein sequence ID" value="ADT83029"/>
        <property type="gene ID" value="TERMP_00051"/>
    </dbReference>
    <dbReference type="GeneID" id="10040370"/>
    <dbReference type="KEGG" id="tba:TERMP_00051"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.52"/>
    <dbReference type="eggNOG" id="arCOG00419">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_1_2_2"/>
    <dbReference type="OMA" id="YNPGHVM"/>
    <dbReference type="OrthoDB" id="93754at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="3">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2">
        <location>
            <begin position="117"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="172" mass="20062" checksum="449784595FE5D013" modified="2011-05-03" version="1">MKIIWAPWRIRYIRSPKHNGCIFCDFPKENRDEERLILYRGKYAFIIMNNYPYNPGHVMIAPYRHVGKWEDLTDDELLEIMKLSQLMIKALKRAMNPDGFNMGVNLGRVAGAGIDDHVHLHIVPRWNGDTNFMPVLADVKVIPQAMEESYKELKRALEEVLSEEHHSTTSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH91</accession>
    <name>F0LH91_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466351.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00075"/>
    <dbReference type="EnsemblBacteria" id="ADT83053">
        <property type="protein sequence ID" value="ADT83053"/>
        <property type="gene ID" value="TERMP_00075"/>
    </dbReference>
    <dbReference type="GeneID" id="10040394"/>
    <dbReference type="KEGG" id="tba:TERMP_00075"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.75"/>
    <dbReference type="eggNOG" id="arCOG05771">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059142_0_0_2"/>
    <dbReference type="OMA" id="KFPIRIN"/>
    <dbReference type="OrthoDB" id="73524at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="395" mass="46099" checksum="6279EDAF08C78331" modified="2011-05-03" version="1">MDELSAPRERYDSVIFVGMTRDGTIEFIKVYGEDKEKALEVLNSFFNEKNLHPADFILVDEGFEDVRDKKIISTRTEDELSAYLARLGLKLLSNGVLYLEGKDRIYQITTVSKELLEKIKGQKEDQGEFEVAETEPHVDVESITDDVPEEFLSSLMLLELREDAIIINEAGLELDKILKKCIKGKVKIPRYLEIYENIIQVFDEEIHEKLASHAEWVLVKTPVICWDYYVDSTEEFEFRKVEDRVYSAPLFLKAYRGYLMLSDPPIELVRKLKRIKRRGYVKFPIGVRYYKIPVDFTLLIETKDASKYEGLEFPVRIKFPSFDEEMLKKLFLKEFGVEIPLSVLRQLPKEYRTMKALKDLKRLVEKLKLRNPEKETSELLKAALVIMIGEGHEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHE6</accession>
    <name>F0LHE6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyhypusine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01298"/>
    <dbReference type="EnsemblBacteria" id="ADT84273">
        <property type="protein sequence ID" value="ADT84273"/>
        <property type="gene ID" value="TERMP_01298"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01298"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1300"/>
    <dbReference type="eggNOG" id="arCOG04142">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039781_1_0_2"/>
    <dbReference type="OMA" id="FWSYFCQ"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="323" mass="36975" checksum="A454A657EBEC4FD6" modified="2011-05-03" version="1">MEINLDEQRVVKDITLRHGMSVNEITKQLFESGGFVAKKFAIAVDILERMIKDKDTFKFLSFPACIMATGTRGIIVDLIKNKLFDAVVTTCGTLDHDLARLWKPYYHGSFLMNDRELHKQGINRLGNVLVPNDSYWIVEEKLQGIFQDIYDSGKRRLATYELVWEIGKRLENEEGKENSFTYWAYKNKIPVFIPGITDGAVGYQLWLFMQDKEDFIVDVFKDETKLDEIMASLASNNKKSGALMIGGGISKHHTIWWNQFWKEGLDYAVYITTAVEWDGSLSGARMREAVSWGKVKEDARYVTVEGDATVLLPFMIASLLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHI3</accession>
    <name>F0LHI3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467608.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01335"/>
    <dbReference type="EnsemblBacteria" id="ADT84310">
        <property type="protein sequence ID" value="ADT84310"/>
        <property type="gene ID" value="TERMP_01335"/>
    </dbReference>
    <dbReference type="GeneID" id="10041651"/>
    <dbReference type="KEGG" id="tba:TERMP_01335"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1335"/>
    <dbReference type="eggNOG" id="arCOG05734">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1032976_0_0_2"/>
    <dbReference type="OMA" id="GNRIWFY"/>
    <dbReference type="OrthoDB" id="84652at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="269" mass="31530" checksum="3F82218FAB4145AD" modified="2011-05-03" version="1">MRFEVLSKNDMIELSKELSKAGIMNKTKEELGWEIQHFIMIKGRYSELVVKSEGFDVIDEKLGEIQQSFEMLMQKWQVGEEKEIGELFDEVDINRLVVLSALIEGGYIVGEEKLKLMKKPKLDDLVIELRFPIDEVEEFLDELEEKMNAKLITEFTFVKRYYVEVLEVEKELIQEALEIAEKYATEESLVDAMFVGVAKSALAEIILEMVKRKNRKNELIEALLEREPIPIEGRREKINIYFDEEALEDLLKELQSLGYIKVKGNRIWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHI7</accession>
    <name>F0LHI7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01339"/>
    <dbReference type="EnsemblBacteria" id="ADT84314">
        <property type="protein sequence ID" value="ADT84314"/>
        <property type="gene ID" value="TERMP_01339"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01339"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1339"/>
    <dbReference type="eggNOG" id="arCOG00903">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081190_0_0_2"/>
    <dbReference type="OMA" id="GYIAHTI"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="208" mass="22683" checksum="081144B349134047" modified="2011-05-03" version="1">MAKVKLVGGDYFKALSSLVIGLSTEFLVVLSFALIFVGFTKVGIFGLILILVALIYEKGIYQVLDSLLKFWESVGIKGLILTLRSYLERIHMGWSEAKENRVVLLISFLLSAVIIFLQVFGIITVGKAFNLEISVKQALYGFLMSILFASVSGIPAGFGANEFGLVLGIGASTKATITAFIYKFLFQYMYSIIGAVVFYGALGEGDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHJ7</accession>
    <name>F0LHJ7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multisubunit sodium/hydrogen antiporter MnhC-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467622.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01349"/>
    <dbReference type="EnsemblBacteria" id="ADT84324">
        <property type="protein sequence ID" value="ADT84324"/>
        <property type="gene ID" value="TERMP_01349"/>
    </dbReference>
    <dbReference type="GeneID" id="10041665"/>
    <dbReference type="KEGG" id="tba:TERMP_01349"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1349"/>
    <dbReference type="eggNOG" id="arCOG03072">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082058_2_3_2"/>
    <dbReference type="OMA" id="GIYMVIA"/>
    <dbReference type="OrthoDB" id="108209at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="97" mass="10332" checksum="1B073E91A6376F53" modified="2011-05-03" version="1">MINAEIAGILIMLIGLYGLMTKKDLIKQVLSVNVASTGLVLFFVGTGYVEGGEVPIMPQQTVVDPLPATLMLTTLVVDVAITSLALAIILRMRGDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHK5</accession>
    <name>F0LHK5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl18</name>
        <name evidence="6" type="ordered locus">TERMP_00111</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466387.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00111"/>
    <dbReference type="EnsemblBacteria" id="ADT83089">
        <property type="protein sequence ID" value="ADT83089"/>
        <property type="gene ID" value="TERMP_00111"/>
    </dbReference>
    <dbReference type="GeneID" id="10040430"/>
    <dbReference type="KEGG" id="tba:TERMP_00111"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.112"/>
    <dbReference type="eggNOG" id="arCOG04088">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056222_2_0_2"/>
    <dbReference type="OMA" id="MAHGPRY"/>
    <dbReference type="OrthoDB" id="108717at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_L18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_L5_euk/L18_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="PTHR23410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="201" mass="23163" checksum="3F63A522D7AF4B19" modified="2011-05-03" version="1">MAHGPRYRVPFRRRREGKTNYHKRLKLLKSGKPRLVVRKTLNHHIAQIIVYDPKGDRTLVSAHTRELMRDFGWKGHGGNTPSAYLLGLLIGYKALQKGISEAILDIGLHPPTRGSSIFAVLKGAVDAGLNVPHSEEIYPEDYRIRGEHIAEYAKMLKEEDEERYRRQFGGYLLKGLEPEKLPEHFDEVKARIIEKFEEARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHK8</accession>
    <name>F0LHK8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl15</name>
        <name evidence="8" type="ordered locus">TERMP_00114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466390.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00114"/>
    <dbReference type="EnsemblBacteria" id="ADT83092">
        <property type="protein sequence ID" value="ADT83092"/>
        <property type="gene ID" value="TERMP_00114"/>
    </dbReference>
    <dbReference type="GeneID" id="26135430"/>
    <dbReference type="KEGG" id="tba:TERMP_00114"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.115"/>
    <dbReference type="eggNOG" id="arCOG00779">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109163_0_0_2"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="OrthoDB" id="121171at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_prot_L15/27a_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="7">
        <location>
            <begin position="29"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="147" mass="16519" checksum="4C596C77260089F9" modified="2011-05-03" version="1">MIRRRKKVRKLRGSHTHGWGCKKKHRGGGHKGGRGMAGTGKRKKTKWTWVIKYMPDHLGKRGFSRPKAVQREIVAVNLKFIDEHLDELMQMGVAYEENGKIIVDTTQFADKVLGTGKLTKPLVIKAYAFSPKAQEKIREAGGEAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHN6</accession>
    <name>F0LHN6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Mevalonate kinase</fullName>
            <shortName evidence="12">MK</shortName>
            <shortName evidence="12">MVK</shortName>
            <ecNumber evidence="2 12">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mvk</name>
        <name evidence="15" type="ordered locus">TERMP_00143</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11 12">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="2 12"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466418.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00143"/>
    <dbReference type="EnsemblBacteria" id="ADT83120">
        <property type="protein sequence ID" value="ADT83120"/>
        <property type="gene ID" value="TERMP_00143"/>
    </dbReference>
    <dbReference type="GeneID" id="10040461"/>
    <dbReference type="KEGG" id="tba:TERMP_00143"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.144"/>
    <dbReference type="eggNOG" id="arCOG01028">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_0_0_2"/>
    <dbReference type="OMA" id="NTVCTYG"/>
    <dbReference type="OrthoDB" id="90882at2157"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00217">
        <property type="entry name" value="Mevalonate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022937">
        <property type="entry name" value="Mevalonate_kinase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="PTHR43290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="13">
        <location>
            <begin position="102"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="14">
        <location>
            <begin position="244"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ADT83120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="333" mass="35194" checksum="7B8B88465747F0FD" modified="2011-05-03" version="1">MRVLASAPAKIILFGEHSVVYGKPAIAAAIDLRTYVWAEFNKNGRIRIEAKDIKIPGLTVSFSESEIYFETDYGKAAEVLSYVREAINLVLEEAGKQKGVTVSITSQIPVGAGLGSSAAVAVATIGAVSKLLGLELTKEEVAKLGHKTELLVQGASSGIDPTVSAIGGFLYYEKGTFEELPAIELPIVVGYTGSSGSTKELVAKVRRSFEEMPDIITPILNSMGKVVEKAKEVILADYDKEIKFQLLGQLMNINHGLLDALGVSTKSLSDLVYASREAGALGAKITGAGGGGCMYALAPGKQSEVATAIKIAGGMPMITKISREGLRIEEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHP3</accession>
    <name>F0LHP3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83127">
        <property type="protein sequence ID" value="ADT83127"/>
        <property type="gene ID" value="TERMP_00150"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00150"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.151"/>
    <dbReference type="eggNOG" id="arCOG01191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_812863_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="45"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="341" mass="40633" checksum="9D63025C392DABE0" modified="2011-05-03" version="1">MIFNITLLNLRISVVTLSENIFNQDVEYLNMEQTMSKDNLKYCWEEYYYIGLQELNSSKCLFEHDFYPQALFHLQQSVEKLVKTVFFMTIWGLYSSNFSLFKKALEDCNILRKSQIGKLTLENFCIELPRMFGHNPTKKYLEFLVCVATKYYEQGPQVVSDNKKEKVDNMIKDLREFLGKPGKVIRGFTPTLVLEKVAEIEHIKMDPDEMRSYLDEHIDSISSENDRIPSETFKYFYKEFLPLFIGWFNAFLDIFEIVWLGILFEADNVHSWTRYPTESMTPLELTEEKMKEFKFLELLDTVGRLYTLPEQILQMKTSFEEKKPLFKKFFKQLVQTQEKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHV4</accession>
    <name>F0LHV4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01379"/>
    <dbReference type="EnsemblBacteria" id="ADT84354">
        <property type="protein sequence ID" value="ADT84354"/>
        <property type="gene ID" value="TERMP_01379"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01379"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1379"/>
    <dbReference type="eggNOG" id="arCOG11923">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2613811_0_0_2"/>
    <dbReference type="OrthoDB" id="122538at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="78" mass="8085" checksum="A665B5705DCAC6AC" modified="2011-05-03" version="1">MAKGSTDIPINTKSSAAVVLGENLPESRELTSRYEGSTQDSDRNAITPPTAKAAGGDVAFSSIRLLFSLNGLETGSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI15</accession>
    <name>F0LI15_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor Spt5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spt5</name>
        <name evidence="6" type="ordered locus">TERMP_00192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Spt5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466467.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00192"/>
    <dbReference type="EnsemblBacteria" id="ADT83169">
        <property type="protein sequence ID" value="ADT83169"/>
        <property type="gene ID" value="TERMP_00192"/>
    </dbReference>
    <dbReference type="GeneID" id="26135522"/>
    <dbReference type="KEGG" id="tba:TERMP_00192"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.193"/>
    <dbReference type="eggNOG" id="arCOG01920">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113589_0_0_2"/>
    <dbReference type="OMA" id="FSEIEHF"/>
    <dbReference type="OrthoDB" id="91936at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00950">
        <property type="entry name" value="Spt5_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011590">
        <property type="entry name" value="Spt5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="PTHR11125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00405">
        <property type="entry name" value="KOW_elon_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NGN" evidence="4">
        <location>
            <begin position="3"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="152" mass="16683" checksum="9760887CCFBD7804" modified="2011-05-03" version="1">MSDSKIFAVRVTVGQEETTARLVYSKAKTYNLPIYAILTPSKVKGYIFIEAPSKSAVDEAIRGIRHARGTLPGEVAFSEIEHFLEEKPAVSGFEPGDIVELIAGPFKGEKAKVIRVDEAKDEIVVELIGAIVPIPVTVRGEYVRLISKRSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI17</accession>
    <name>F0LI17_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl1</name>
        <name evidence="8" type="ordered locus">TERMP_00194</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds directly to 23S rRNA. Probably involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466469.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00194"/>
    <dbReference type="EnsemblBacteria" id="ADT83171">
        <property type="protein sequence ID" value="ADT83171"/>
        <property type="gene ID" value="TERMP_00194"/>
    </dbReference>
    <dbReference type="GeneID" id="26135524"/>
    <dbReference type="KEGG" id="tba:TERMP_00194"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.195"/>
    <dbReference type="eggNOG" id="arCOG04289">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_4_0_2"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="OrthoDB" id="70269at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_A">
        <property type="entry name" value="Ribosomal_L1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023669">
        <property type="entry name" value="Ribosomal_L1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="217" mass="24091" checksum="7470A79C5A80E812" modified="2011-05-03" version="1">MAFDRQKIVEAVKEAKARAKPRNFTQTVEVAVNLKDIDLRKPENRFKLEVVLPHGRGKDVKIAVIADGAVAEAAKKLGLDVISGEQLEEIAKSPREARKLAKKYDFFIAAAPLMPKIGRYLGRYLGPRNKMPVVVPPTLTNLEPIVNKLKKTVRIQLKNNPVVHAPVGTETMEDEKIAENIETVLNAIIGKLERGENQVKSVYVKTTMGPAVKVEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI46</accession>
    <name>F0LI46_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00223"/>
    <dbReference type="EnsemblBacteria" id="ADT83200">
        <property type="protein sequence ID" value="ADT83200"/>
        <property type="gene ID" value="TERMP_00223"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00223"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.223"/>
    <dbReference type="eggNOG" id="arCOG00722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3210929_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="44" mass="5036" checksum="8E09B8065D2C5B9C" modified="2011-05-03" version="1">MSLGKAAKLADITKREFLKELAKRGIPRHYTEKELKEDLEFACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIA5</accession>
    <name>F0LIA5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467733.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01460"/>
    <dbReference type="EnsemblBacteria" id="ADT84435">
        <property type="protein sequence ID" value="ADT84435"/>
        <property type="gene ID" value="TERMP_01460"/>
    </dbReference>
    <dbReference type="GeneID" id="26136950"/>
    <dbReference type="KEGG" id="tba:TERMP_01460"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1460"/>
    <dbReference type="eggNOG" id="arCOG02611">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109676_0_1_2"/>
    <dbReference type="OMA" id="STVSWHL"/>
    <dbReference type="OrthoDB" id="115607at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="58"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="172" mass="20316" checksum="BB1F6971CDDA5741" modified="2011-05-03" version="1">MTHREEILQYIYKNPGITFRRLAEELGIGIGNLQYHLYQLEKENKIVSKKLGGKRYIFPKEFEKEYEPLLIAISNETQRKILLLLAEREMNQREIAERLKLTQATINYHMNVLNKLGLIDRRKQGRNVVYSLKCDIEVIVRVISEYRPKLWDKLADKLIDLMLTLKGGELND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIA7</accession>
    <name>F0LIA7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467735.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01462"/>
    <dbReference type="EnsemblBacteria" id="ADT84437">
        <property type="protein sequence ID" value="ADT84437"/>
        <property type="gene ID" value="TERMP_01462"/>
    </dbReference>
    <dbReference type="GeneID" id="26136952"/>
    <dbReference type="KEGG" id="tba:TERMP_01462"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1462"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_1_2"/>
    <dbReference type="OMA" id="KWSQKAA"/>
    <dbReference type="OrthoDB" id="99962at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="149" mass="16596" checksum="E38BE35918C40916" modified="2011-05-03" version="1">MRILVLIDGSKWSQKAALHAIAIAKKKNAKVILFSVLDRREAKAIAFNLSMRSDKIGEIKKFEEQIWKEMKKSVKEIMEGLLELCHEENVNCSMKIVEGIAKDEILKEANSGAYSLVVMGAYGKSGKTRIGSLLEELAGIIKPPLLIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LID0</accession>
    <name>F0LID0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-hydrogenase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT84460">
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        <property type="gene ID" value="TERMP_01485"/>
    </dbReference>
    <dbReference type="GeneID" id="26136973"/>
    <dbReference type="KEGG" id="tba:TERMP_01485"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1485"/>
    <dbReference type="eggNOG" id="arCOG01543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01609">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_4_6_2"/>
    <dbReference type="OMA" id="VLCGHCE"/>
    <dbReference type="OrthoDB" id="93710at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="190" mass="21224" checksum="03A8351ABB132133" modified="2011-05-03" version="1">MKIPPTLSTVLSNLFKKPATNMFPKTEPVPTPEGFRGKLVYDVDKCIGCKLCVTVCPAGVIEFVPEIKKVTFWLGRCVFCAQCVDVCPVNALEMSKEFLLATYDKYDDNLRWLKNEEIEEMIEAQKSKKVKKYRIIPDKCKGCTLCARNCPQNAITGAPGKVHKIDPNKCVGCGICASVCRFGAIEEYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIF7</accession>
    <name>F0LIF7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">TERMP_01512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
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            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01512"/>
    <dbReference type="EnsemblBacteria" id="ADT84487">
        <property type="protein sequence ID" value="ADT84487"/>
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    </dbReference>
    <dbReference type="GeneID" id="10041828"/>
    <dbReference type="KEGG" id="tba:TERMP_01512"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1512"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1451468_0_0_2"/>
    <dbReference type="OMA" id="HSRHISE"/>
    <dbReference type="OrthoDB" id="83821at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="189" mass="22208" checksum="90887373E1C6C784" modified="2011-05-03" version="1">MKVEVPYLVFEVNGEEYMIDAHFSKKLERIERISALIRPVDRTLSETAEEPLPILLQKNEIEGFLKNLFVEVYESSGEKLNKRLRHMRKWNILRLIGIPTGFSRHVEKDEHLAKENREAMLSLAILRKILGVKTPTELDKIKIVPKEYLYYRIELKNREIFNEKGEKDGIYTQLLEIDGGFRHALLSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIG7</accession>
    <name>F0LIG7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00264"/>
    <dbReference type="EnsemblBacteria" id="ADT83241">
        <property type="protein sequence ID" value="ADT83241"/>
        <property type="gene ID" value="TERMP_00264"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00264"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.264"/>
    <dbReference type="eggNOG" id="arCOG08611">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2191166_0_0_2"/>
    <dbReference type="OMA" id="DRFMIYN"/>
    <dbReference type="OrthoDB" id="106331at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="109" mass="12604" checksum="DC7C8197DEE0A02E" modified="2011-05-03" version="1">MGGFLVYNAEGRSLVIDANIGERFSFYCPKEECETEIVIEGVIRHATFDEFVRVRDHIIEQNKEFKVLRDVLPKEPVIFEGTVNGKKVKLPVEKLDEAAKRFINKYLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LII6</accession>
    <name>F0LII6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00283"/>
    <dbReference type="EnsemblBacteria" id="ADT83260">
        <property type="protein sequence ID" value="ADT83260"/>
        <property type="gene ID" value="TERMP_00283"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00283"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.283"/>
    <dbReference type="eggNOG" id="arCOG04222">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1269992_0_0_2"/>
    <dbReference type="OMA" id="LQFYKGR"/>
    <dbReference type="OrthoDB" id="78483at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="220" mass="26303" checksum="73CCC56AA627A3A8" modified="2011-05-03" version="1">MDIKVSPEFLLVLMVLAGVASIQFFKGRKLNLMLMQHYLRAFEDTIKPKDKEYVWLGGYIGFRAYYKVSEGNIDKFEYTLTLLPRQSIFYMPISKLISRHDKLYIVVRPYSQIKREAHLIQKRYYRIKPKIEDEELLQKDVIESGRKEYEALFEKRRDVELLREFLQGFSKPENVKHVSLTPKTNVFYILMKPEPETIQDDIRHIVRFVNEKLKESPFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIJ8</accession>
    <name>F0LIJ8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466570.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00295"/>
    <dbReference type="EnsemblBacteria" id="ADT83272">
        <property type="protein sequence ID" value="ADT83272"/>
        <property type="gene ID" value="TERMP_00295"/>
    </dbReference>
    <dbReference type="GeneID" id="10040613"/>
    <dbReference type="KEGG" id="tba:TERMP_00295"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.295"/>
    <dbReference type="eggNOG" id="arCOG00717">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115769_1_0_2"/>
    <dbReference type="OMA" id="CAVHEEL"/>
    <dbReference type="OrthoDB" id="101018at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021799">
        <property type="entry name" value="DUF3368"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11848">
        <property type="entry name" value="DUF3368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="154" mass="17723" checksum="B8E26B8474CBF2E4" modified="2011-05-03" version="1">MPIISDTSPLILLKKTGGIYLLEELFNEVVIPLQVQKELYVREEHYFSRIKFLKVQNPKKELFKILLLTLDEGEAGAIALAIEHGLPLLIDDLKGRKTAKQLGLKYIGTLGILKIAKNRKIISEVRPFIEKLLRSGYYISPKLVEKFLREMEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIQ5</accession>
    <name>F0LIQ5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="8">DHOD</shortName>
            <shortName evidence="8">DHODase</shortName>
            <shortName evidence="8">DHOdehase</shortName>
            <ecNumber evidence="8">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pyrD</name>
        <name evidence="10" type="ordered locus">TERMP_01532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="8">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467805.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01532"/>
    <dbReference type="EnsemblBacteria" id="ADT84507">
        <property type="protein sequence ID" value="ADT84507"/>
        <property type="gene ID" value="TERMP_01532"/>
    </dbReference>
    <dbReference type="GeneID" id="10041848"/>
    <dbReference type="KEGG" id="tba:TERMP_01532"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1532"/>
    <dbReference type="eggNOG" id="arCOG00603">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042042_0_1_2"/>
    <dbReference type="OMA" id="SCPHAKG"/>
    <dbReference type="OrthoDB" id="31316at2157"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="9">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT84507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="299" mass="32307" checksum="4EF8E88BF2B4288D" modified="2011-05-03" version="1">MLSIEVAKLKLENPLILASGVADMTPDLLRRAHKEGAGAVVTKSIGIEPRKGYNNPTIVELPYGLINAMGLPNPGWEAFYKEFKNEKFDFPVIVSIFGKDEREFAFLAEKLSEVADAFELNLSCPHAKGYGMEIGQNPEMVYKVVKAVKDTTDKPVIAKLTPNIDDITKIGLAAERAEADAVSAINTVKAVAIDIYARRPILSNKVGGYSGPGIKPIALRAVYDLAKVLDIDIIGVGGITTWQDAVEFLMAGAKALQIGTAVSLRGFKVFKEINEGIGRFLNEEGFNSIEEIVGIALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIU6</accession>
    <name>F0LIU6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fumarate hydratase class I aerobic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_01573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467846.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01573"/>
    <dbReference type="EnsemblBacteria" id="ADT84548">
        <property type="protein sequence ID" value="ADT84548"/>
        <property type="gene ID" value="TERMP_01573"/>
    </dbReference>
    <dbReference type="GeneID" id="10041889"/>
    <dbReference type="KEGG" id="tba:TERMP_01573"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1573"/>
    <dbReference type="eggNOG" id="arCOG04407">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041245_0_0_2"/>
    <dbReference type="OMA" id="IETYPTH"/>
    <dbReference type="OrthoDB" id="59419at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT84548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="287" mass="31594" checksum="09420FE17574883C" modified="2011-05-03" version="1">MEEKLTEAVIEAIRLAATNLPEDVINAIKGAYEREESRIAKFNLENILKSIEIGKNERIPICQDTGTITFFVEAGIKNPYLSEIGEILLEATRRATQEIPLRPNAVDVLTNKNSGDNTGRFVPIIHWELVEGNRIRIAVLPKGGGSENCSALAMLNPIEGFEGVKRFIVKRVRECGGKPCPPVILGVGIGGSADLALKLAKKSLLRPLGMRHENERIAQLEEEILDKVNSLGIGPMGMGGRTTALDVKIEYAHRHPASLPVGLIIQCWAHRKAFIEVDEKGKVKIWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIW5</accession>
    <name>F0LIW5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467865.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01592"/>
    <dbReference type="EnsemblBacteria" id="ADT84567">
        <property type="protein sequence ID" value="ADT84567"/>
        <property type="gene ID" value="TERMP_01592"/>
    </dbReference>
    <dbReference type="GeneID" id="10041908"/>
    <dbReference type="KEGG" id="tba:TERMP_01592"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1592"/>
    <dbReference type="eggNOG" id="arCOG13980">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131910_0_0_2"/>
    <dbReference type="OMA" id="LNMRIIN"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="173" mass="20030" checksum="17C1AFD3F2D60C89" modified="2011-05-03" version="1">MSDFDFNELIKLLFLLPIIIIFLGLILKTTSILEEGACQPYIQQIQQKEAQIKALNKQIEVLNEKLANLSAEYERLRTENITKADIEEIKQQINITQLQINYLDQQLQIVNENFIHAYNVYYKTYVFSIALNIALAGYITLDLISATLFNTSIQVLIAKKIKVILKRLHKTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIZ1</accession>
    <name>F0LIZ1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA protection during starvation protein</fullName>
            <ecNumber evidence="1">1.16.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 Fe(2+) + 2 H(+) + H2O2 = 2 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:48712"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EC" id="1.16.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466635.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00360"/>
    <dbReference type="EnsemblBacteria" id="ADT83337">
        <property type="protein sequence ID" value="ADT83337"/>
        <property type="gene ID" value="TERMP_00360"/>
    </dbReference>
    <dbReference type="GeneID" id="40474863"/>
    <dbReference type="KEGG" id="tba:TERMP_00360"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.360"/>
    <dbReference type="eggNOG" id="arCOG01093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104506_4_0_2"/>
    <dbReference type="OMA" id="TFYYYTI"/>
    <dbReference type="OrthoDB" id="61631at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01052">
        <property type="entry name" value="DPSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014490">
        <property type="entry name" value="Dps-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033921">
        <property type="entry name" value="DPSL_diiron-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018063">
        <property type="entry name" value="Ferrtn_UCP018063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018063-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="183" mass="21171" checksum="C54F5568CE076169" modified="2011-05-03" version="1">MSEHNRRLVEKAGIDVEKLLDMLLKAAAAEFTTYYYYTVLRNHAAGMEGETIKEIIEDARLEDRNHFEALVPRIYELGGELPRDIVDFSKMAWCRDAYLPEEPTVENILKVLLEAERCAVGVYTEICKYTFGKDPRTYDLALAILHEEIEHEAWFEELLTGKPSGHFRRTKPGESPFVSKFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ71</accession>
    <name>F0LJ71_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01618"/>
    <dbReference type="EnsemblBacteria" id="ADT84593">
        <property type="protein sequence ID" value="ADT84593"/>
        <property type="gene ID" value="TERMP_01618"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01618"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1618"/>
    <dbReference type="eggNOG" id="arCOG04151">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048986_0_1_2"/>
    <dbReference type="OMA" id="FPIITSK"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007254">
        <property type="entry name" value="DUF373"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38815">
        <property type="entry name" value="PTHR38815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04123">
        <property type="entry name" value="DUF373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="374" mass="41045" checksum="B02B2706E9531AEF" modified="2011-05-03" version="1">MAIDRDDDFGVKAGVKGPVIGRDACIDAALKLSLADPEDSDANVVYAAVKLHDELKESGEFEDVKVALITGHHDVGVKSDLELSKQLDEVLKVFPADGIIPVTDGAEDEQIFPIITSKVPIISSRRVVVKQSESIETTYYIIYRYLKEILSEPEVAKVVFGLTGLVMLLYGVAKLISVKYPQSVQIVSATVTGTILFIIGTYLFSKGFRIHVSLRETITKGFIEFISVIAGMLVMVAGAINAYLNLEYIAMEKLGGLPGTQLIAVLLYLNILKTPFVVGLGVMVLGKVLQSYLRKDPHIWYYITGLLLLPALWITIDLTTLYAMSTVSPYLLQFFKKIVMAIGDVVVGTLIGIYLREKVKGWEKIEIGKSPEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJA3</accession>
    <name>F0LJA3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467923.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01650"/>
    <dbReference type="EnsemblBacteria" id="ADT84625">
        <property type="protein sequence ID" value="ADT84625"/>
        <property type="gene ID" value="TERMP_01650"/>
    </dbReference>
    <dbReference type="GeneID" id="10041966"/>
    <dbReference type="KEGG" id="tba:TERMP_01650"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1649"/>
    <dbReference type="eggNOG" id="arCOG00419">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_5_0_2"/>
    <dbReference type="OMA" id="YNIGVNC"/>
    <dbReference type="OrthoDB" id="93754at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2">
        <location>
            <begin position="92"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="149" mass="17125" checksum="6478FB3956DE68E8" modified="2011-05-03" version="1">MKCPFCNASPEVLLYEDDLIRILIDSYPANRGHLLVTPKRHVEKWEELSFEEKIALLRGVELAIEKLKQTLNPDGFNVGINLGKAAGQTVPHLHIHVIPRYEGDTNFPRGGVRKAVLDVEDENLKLKERWIKNRMSKEETEKLRQAFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJD7</accession>
    <name>F0LJD7_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="10" type="ordered locus">TERMP_00426</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466701.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00426"/>
    <dbReference type="EnsemblBacteria" id="ADT83403">
        <property type="protein sequence ID" value="ADT83403"/>
        <property type="gene ID" value="TERMP_00426"/>
    </dbReference>
    <dbReference type="GeneID" id="10040744"/>
    <dbReference type="KEGG" id="tba:TERMP_00426"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.426"/>
    <dbReference type="eggNOG" id="arCOG04133">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_0_0_2"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="OrthoDB" id="50229at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="293"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT83403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="360" mass="39684" checksum="85B28C6E3B099ED7" modified="2011-05-03" version="1">MMGRMLRFSLFGESHGRVVGVLIEGVPPGIKVNLEKMKAELERRKGIRRFSTKRRENDEPVILSGVFNGFTTGFPIAVIIENKDVDSSYYEEIKNTPRPGHSDYTAKIKYFGFNDYRGGGFFSGRLTAGIVIAGYFAKEILAKAGIEVKAYIKSIGNIKAKDLSVEEIFISKNSFCPDEEAFQKMLEEMERARKEGDSVGGVVEVVAINVPPGIGGPYDEDLEGDLAKAFFAIPAVKGVEFGLGFKLAELRGSEANDPFVVKDGKIMTETNNCGGILGGISNGMPIVARIAFKPTPSIYKPQRTVDLEKMEETEIKLRGRFDSCIVPKALPVIEAMMALILADHLLRWLSWKGLMSLGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJE0</accession>
    <name>F0LJE0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prephenate/arogenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466704.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00429"/>
    <dbReference type="EnsemblBacteria" id="ADT83406">
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    </dbReference>
    <dbReference type="GeneID" id="10040747"/>
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    <dbReference type="eggNOG" id="arCOG00245">
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    </dbReference>
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    <dbReference type="OMA" id="IVAVPFW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDH_ADH"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="261" mass="30102" checksum="914DEF9A1B0607A2" modified="2011-05-03" version="1">MRIGVIGYGKMGKLFAREFSTKHEVGIYSRHAKGIEFKLFGSIDELFKWADVIIVAKSLEEIPQVLETLAKLSEKSQGKAIFDISTFKRDVIEIYKRFPESVNVCSVHPMFGAGAENFEGRRFIVIPVEGREGDITPVINLFKEFKAEVFIADAKTHDEMMKLVIGIPYFIGISFLSFLSEFEGVENFGGTSFEYLATYAKAVLNDSPEFIKEVLEFSKDKLREFLRFAEKGEFDIEMLRKKFEHEIEERYKRFYKVLSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJG1</accession>
    <name>F0LJG1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00450"/>
    <dbReference type="EnsemblBacteria" id="ADT83427">
        <property type="protein sequence ID" value="ADT83427"/>
        <property type="gene ID" value="TERMP_00450"/>
    </dbReference>
    <dbReference type="GeneID" id="10040768"/>
    <dbReference type="KEGG" id="tba:TERMP_00450"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.450"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_1_2"/>
    <dbReference type="OMA" id="APIKVYM"/>
    <dbReference type="OrthoDB" id="83765at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="11"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="75"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="135" mass="15414" checksum="92A47341AFD62DC1" modified="2011-05-03" version="1">MERNAPIKVYMTRKLIGVNPDDTIQEACRIMVKFDIGSLVVIENDRVVGFFTKSDIIRRVIVPGLPYTTPVKEIMTRELITTDANTPVREVLKTMAYHRIKHILIEEEGKIVGIFTLSDLLEATRRKLETSISVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJG4</accession>
    <name>F0LJG4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_00453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466728.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00453"/>
    <dbReference type="TCDB" id="2.A.42.1.7">
        <property type="family name" value="the hydroxy/aromatic amino acid permease (haaap) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83430">
        <property type="protein sequence ID" value="ADT83430"/>
        <property type="gene ID" value="TERMP_00453"/>
    </dbReference>
    <dbReference type="GeneID" id="10040771"/>
    <dbReference type="KEGG" id="tba:TERMP_00453"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.453"/>
    <dbReference type="eggNOG" id="arCOG10063">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650091_0_0_2"/>
    <dbReference type="OMA" id="FAYVSHM"/>
    <dbReference type="OrthoDB" id="46986at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018227">
        <property type="entry name" value="Amino_acid_transport_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03222">
        <property type="entry name" value="Trp_Tyr_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="367" mass="39070" checksum="C0FE930C377029EA" modified="2011-05-03" version="1">MKKLSLAEASAILIGTQIGAGVLGLPYALKDTGLLGIIIVIATGLLTLLTALFVLDLAAHSDGTLSKIAEAYLGKIGGYLMFLSISVLSYGALIAYIAGSGDILSSLFGINEKTGALIFWFVMSLIVFLGLKASGEAELLLNFLLLGALTLAIALVMPKADVSNLTKIDYSAITKGIGVAVFAYVSHMVVPEMLKGLGDVKKTTKAVLIGYLVPMVFYAFFVLAFVGTFGSKTPELATSALEQLYGRLGSVLGLILPLAAISTSYIGIGLAQMDNMKEIFGIKRSHAWLLTVIPPLLVYFAGLNSFVNALWMAGTFGGLLYAGILPTVMYIKAKKIHRKLHLPIPHSFVYLSGLVFFLVFIYSILSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJH1</accession>
    <name>F0LJH1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formate dehydrogenase H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466735.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00460"/>
    <dbReference type="EnsemblBacteria" id="ADT83437">
        <property type="protein sequence ID" value="ADT83437"/>
        <property type="gene ID" value="TERMP_00460"/>
    </dbReference>
    <dbReference type="GeneID" id="10040778"/>
    <dbReference type="KEGG" id="tba:TERMP_00460"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.460"/>
    <dbReference type="eggNOG" id="arCOG01492">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_4_0_2"/>
    <dbReference type="OMA" id="DGPPCCY"/>
    <dbReference type="OrthoDB" id="1029at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015942">
        <property type="term" value="P:formate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02753">
        <property type="entry name" value="MopB_Formate-Dh-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041924">
        <property type="entry name" value="Formate_Dh-H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006478">
        <property type="entry name" value="Formate_DH_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01591">
        <property type="entry name" value="Fdh-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="660" mass="74284" checksum="1300E3E8E4ED1611" modified="2011-05-03" version="1">MKSVICPYCGFGCRLRVNPETLTVIPDKTSPVNRGRICPKGLRATEFAVHRDRLKKPLKAVGRKFIPISWSQAIGEISHKLLEIRELYGPDAVAFIASSKCSNEENYLLQKIARLFGTNNIDNCARLCHESSVHALKATLGMGVQTNPYEDLEKFNAILIWGYNPAETHPVVMHYISEAKRRNAKVIVVDVRETMSSEWADYFLKIIPGTDIVLANAIMHVIIRDELYDEEFVENMTKGFNEIRMAVRKYTPEYAERITGIRSEIIEEVAKAFALAGSGAVMWGMGITQHVSGVDNVLALIDLALLLGYVGEKGGLYPMRGQNNVQGAAYMGALSEYLPGYVELTDMEFRRRVTRIWNTDKIPTERGLYLTEFFDAIAKGEVLALYVMGENPAVSEANSRKVVEALKKLELLVVQDIFPTKTSRYAHYILPAAAFCEKEGSYMNSERRIQWSSKVCDPPGDAKPDWEILTLLGKALGLPSFDYKMVEEITAEYFKLFPELEDREIEELKTPEGVIIPKKRLHTWSFATPDGKAHFKAVEYILPWETPDDEYPFILVTMRTMNSYNTGEMSLRSPSLAKLMKAPMAEISKEDAKRLGIRDGELIIIETRRGRIRIKAKIGDIKSGVVAVPFHSKVNRITSDALNKAGTPELKFSACKVYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJK2</accession>
    <name>F0LJK2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466766.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83468">
        <property type="protein sequence ID" value="ADT83468"/>
        <property type="gene ID" value="TERMP_00491"/>
    </dbReference>
    <dbReference type="GeneID" id="10040809"/>
    <dbReference type="KEGG" id="tba:TERMP_00491"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.491"/>
    <dbReference type="eggNOG" id="arCOG03808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096716_0_0_2"/>
    <dbReference type="OMA" id="AWITSIS"/>
    <dbReference type="OrthoDB" id="82291at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="256" mass="28855" checksum="0A366C8C39044DAA" modified="2011-05-03" version="1">MNIEGEILIQEIFKKEIMPNSIVSVIYDTYSSAWLISFALLKNEVDKGGFGIISNYNLPLPNLFRAAEFVGLDLSAELERGNAAIIDVFGSKYGSRFNLKNVFYLNYVDPETINPKIDMIYENRIKPLLGDRKAFRVVYTLDGAALMLGEHMTLKLLNQTIAVKTKLMPNSVLVLPLNKDVVSQRFVAWITSISEYVIVASSKIGDEGLEERLHLVKSPLEEFAPSTYTMWTTKGKKAERLRVKKLTPEFGPLGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJK4</accession>
    <name>F0LJK4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase MptA</fullName>
            <ecNumber evidence="3">3.5.4.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GTP cyclohydrolase IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mptA</name>
        <name evidence="4" type="ordered locus">TERMP_00493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25860"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58854"/>
            <dbReference type="EC" id="3.5.4.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="3">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP cyclohydrolase IV family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.39" evidence="3"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466768.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00493"/>
    <dbReference type="EnsemblBacteria" id="ADT83470">
        <property type="protein sequence ID" value="ADT83470"/>
        <property type="gene ID" value="TERMP_00493"/>
    </dbReference>
    <dbReference type="GeneID" id="10040811"/>
    <dbReference type="KEGG" id="tba:TERMP_00493"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.493"/>
    <dbReference type="eggNOG" id="arCOG04301">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062816_1_0_2"/>
    <dbReference type="OMA" id="PCSQGMS"/>
    <dbReference type="OrthoDB" id="109805at2157"/>
    <dbReference type="UniPathway" id="UPA00065"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003933">
        <property type="term" value="F:GTP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01527_A">
        <property type="entry name" value="GTP_cyclohydrol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003801">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2/MptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022840">
        <property type="entry name" value="GTP_cyclohydrolase_MptA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36445">
        <property type="entry name" value="PTHR36445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02649">
        <property type="entry name" value="GCHY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="May be catalytically important" evidence="3">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="270" mass="30924" checksum="8A88EDBBFFBE3738" modified="2011-05-03" version="1">MGEIFETQEEVPEIKEKLHRVGITNLRTVAKINWKGKLYTFIPTFEITIDVPEEKKGIHMSRLVESITETMSEAVEEEVSRVHSSLEELELAIIKRLEKKHPHKRAEVWIKTHLIIGKETPASKKISLEAYDVEVGVIKDETKGKLEKVLKVTVIGNTACPHAMANNQGKTHIQRAIATLEIQTDFDEEIALEDMVEVVESSFSSPTYTLLKTVDENAVVQKMYQNPKFVEDVAREIIFKAKQRFKGRIHVRVVSLESIHKHDVIAETWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJL5</accession>
    <name>F0LJL5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01682"/>
    <dbReference type="EnsemblBacteria" id="ADT84657">
        <property type="protein sequence ID" value="ADT84657"/>
        <property type="gene ID" value="TERMP_01682"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01682"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1681"/>
    <dbReference type="eggNOG" id="arCOG05872">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3075544_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="52" mass="6111" checksum="43E9B9DD1D0F92E4" modified="2011-05-03" version="1">MSYSYRVYGVDYPYSLLSLLAFVFMIVGSALSVYGYIRFMEGAVEKTRKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJP3</accession>
    <name>F0LJP3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01710"/>
    <dbReference type="EnsemblBacteria" id="ADT84685">
        <property type="protein sequence ID" value="ADT84685"/>
        <property type="gene ID" value="TERMP_01710"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01710"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1709"/>
    <dbReference type="eggNOG" id="arCOG13983">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1478988_0_0_2"/>
    <dbReference type="OMA" id="SEFIHET"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="194" mass="21551" checksum="A3926EB237E5AE88" modified="2011-05-03" version="1">MRWKSTILLACFMIQAVVNLAFYGFVPIMFSTIVPSYAYRYIAWALPFLILAFFALGTISLYYLGIATNFKRAKKFGAVYFLFGLFGSLWALFHFMRTPVETPILFAILGAWALSSLVGLIIFLKGKEISVSPALSIMAIALLSASAFLSAFSAQWLVSDYYVHVKMEENVPKNATVIVAYPEQVPPPNITSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJR7</accession>
    <name>F0LJR7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468007.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01734"/>
    <dbReference type="EnsemblBacteria" id="ADT84709">
        <property type="protein sequence ID" value="ADT84709"/>
        <property type="gene ID" value="TERMP_01734"/>
    </dbReference>
    <dbReference type="GeneID" id="10042050"/>
    <dbReference type="KEGG" id="tba:TERMP_01734"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1733"/>
    <dbReference type="eggNOG" id="arCOG03269">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_439177_0_0_2"/>
    <dbReference type="OrthoDB" id="132308at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="622" mass="70575" checksum="E6F142F624AC9859" modified="2011-05-03" version="1">MKKVIVILMLLLCFSLPVSAQNESKIFVWLRIGESVTIGTYTIKVVDVDKDFAKALIQVYRYGLLYRMGTISVNEGLMVDNIQIYLEDSFKSEIYPAVLLEIDVPYFKVGESIVLKNKQIEVIKANESYAELDLGYANVTLSKERTYYKDKNFEIKLNPLDYLFREYIYKDQSGDIIYKGISDGKALLVIKNKTYELSKGEKIYVDDVTLLTLLEFDENRALVRLDLVNATYLTVKEMPYFEGFIAEHEKVRLSKLYELEVSNFIDENHVEVALYRAGNMVEKKVLSTDNPYLVYYPLAIKFKYGFAGIRNNLAYFVIFADEKALKREEEGIRIPILDIKVKLPEKVHLGENIPLNLTIRNIGDAPAENLEVIIFTDGMKSRTLTPSFLPNATIIDNSTITIEKENQSLIIEILYDYNGKAYRRIIKHKFEVLDPEITFSAKLNLPDNATLGVPFNATVTYTIYTNYPSSFVLTIEGNGITYLSSPIMTAESPSEGTFTVEIAPVKTGNLTLKLESLFPKKQILDTATIPVYQFKKVQIVEKVVEKYINCENTTQNITTPNQPAIQCPNETKIVYTPVEKVVEKEVLPIGKTSLIAIISLLLGIVLGSLLLGEKLKNILERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJR8</accession>
    <name>F0LJR8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LSU ribosomal protein L41e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="F0LJR8"/>
    <dbReference type="STRING" id="391623.TERMP_01735"/>
    <dbReference type="EnsemblBacteria" id="ADT84710">
        <property type="protein sequence ID" value="ADT84710"/>
        <property type="gene ID" value="TERMP_01735"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01735"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1734"/>
    <dbReference type="eggNOG" id="arCOG06624">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_219591_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="37" mass="5001" checksum="3F28958580287889" modified="2011-05-03" version="1">MKRRPRKWKKKGRMRWKWIKKRIRRLKRQRKKERGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJS9</accession>
    <name>F0LJS9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA(Met) cytidine acetyltransferase TmcA</fullName>
            <ecNumber evidence="9">2.3.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tmcA</name>
        <name evidence="11" type="ordered locus">TERMP_01746</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43788"/>
            <dbReference type="Rhea" id="RHEA-COMP:10693"/>
            <dbReference type="Rhea" id="RHEA-COMP:10694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TmcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.193" evidence="9"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468018.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01746"/>
    <dbReference type="EnsemblBacteria" id="ADT84721">
        <property type="protein sequence ID" value="ADT84721"/>
        <property type="gene ID" value="TERMP_01746"/>
    </dbReference>
    <dbReference type="GeneID" id="10042062"/>
    <dbReference type="KEGG" id="tba:TERMP_01746"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1745"/>
    <dbReference type="eggNOG" id="arCOG01951">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004652_1_0_2"/>
    <dbReference type="OMA" id="NEPDDLG"/>
    <dbReference type="OrthoDB" id="2707at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01886">
        <property type="entry name" value="tRNA_acetyltr_TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="Helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024914">
        <property type="entry name" value="tRNA_acetyltr_TmcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="PTHR10925"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="DUF1726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="Helicase_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="10">
        <location>
            <begin position="472"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="9">
        <location>
            <begin position="592"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="632"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="639"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT84721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="817" mass="94079" checksum="9EA29EA6E08FD11E" modified="2011-05-03" version="1">MTVKIRFDKEVREYAKGEKVKDSLLKLTETALAEALENFHRRMIVLQGESMNKAKLAGILGGASAKVLSSLIDELIARKLRDESEEKVEVLYATDALGEGTFGRARYEEFRKHFDILADENAELTRVTFKYTSDILGRTFDLLILDLSYDFSPNDLGRIIETVRGGGLIFVLTNPFEKWKNMWTGFHKNLVTPPYTIDDVKKRFNRRLIRKFEEHEGIYIVNAENQKLLKKPKKSKSQAKLPEREKIEIPEETKFPKELYELCLTNGQVEVLKNLEALIEDEGMVVLTADRGRGKSVSVGIGVVGLALSSKRRRFRAVITAPELENVQSLFRFAKKSLEILGYRVKVVTEKNLIKELYAKGIGLRYYPPTLGYKKNADVYVLDEAAGIHVPILHKYLEKPKVIYSSTIHGYEGAGRGFSVKFLKKAKEKREFREIHLSVPIRYSSRDPIEKWLFDVLLLDAEPAPLTKEDYEMIRKKEVYFEEPDLDDWFENDREDLKHFVGIYVLAHYRNRPSDVALLADAPHHEARVLRLKNGKIVCAIQIAKEGGIPKGVIEKMAKGYKPRGNIIPDMMVKHHYAKEFAKLKGYRVVRIATHPDAMDMGLGSKALELLIKEAEEKGYDWVGSGFGASEELIRFWIRNGFAVVHLSPSRNPVSGEYTAIVIKPISERAKEIVKQANAEFRIRLLDWLGDTHRDLEPEIARWLFESPFGEAVDYPVHLTKTQIKRLEMFVSKVLTYDTVVDAVKPIVKLYFLDGWMRPYLDERQVLLLIYRVLQAHTWEETAKFIDRTPLFTMIEVRDIIRGLWYYYKHIIKGFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJU5</accession>
    <name>F0LJU5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CytX-like hydroxymethylpyrimidine transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466780.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00505"/>
    <dbReference type="EnsemblBacteria" id="ADT83482">
        <property type="protein sequence ID" value="ADT83482"/>
        <property type="gene ID" value="TERMP_00505"/>
    </dbReference>
    <dbReference type="GeneID" id="10040823"/>
    <dbReference type="KEGG" id="tba:TERMP_00505"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.505"/>
    <dbReference type="eggNOG" id="arCOG03447">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048240_1_1_2"/>
    <dbReference type="OMA" id="NTIYNFA"/>
    <dbReference type="OrthoDB" id="23625at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012732">
        <property type="entry name" value="Thia_CytX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02358">
        <property type="entry name" value="thia_cytX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="425" mass="46081" checksum="33EA9FC864C51DAF" modified="2011-05-03" version="1">MDGGYDIRPTSERTFTFLTLFAIWFGAGISIAEFWAGALLTPALPLLTAIAVIIIGHLIGNAVMGLIAIEGEETGVPTMVLSRGALGIKGSVLPSILNYLQLIGWTAIMLIVGANAMNAVSKHFGFESYALWVVLLGLLVTAWTYIGPKNWDKLEKAAAALLLVLSIWLTYVTLKQFSLNEILSKPGTGEMGTMLALDLVIAMPLSWAPLIADYSRFAKDKSSAFWGTYIGYFISSSLFYFVGALTNMAIGESDPIGIIAAYGIGIPAMLIIVFSTVTTTFLDVYSAAITYKNISPRADARKQVLLVGALGTLLALVFPVDQYESFLLLIGGAFVSLTAIMITDYFLVKKGYNAEELLDENGKFAGYNRKALIIWALGFVFYMLLAVEGLFGVHIPVLSDVGFKLGSSIPTFVLVSVLYYLSERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJW0</accession>
    <name>F0LJW0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT83497">
        <property type="protein sequence ID" value="ADT83497"/>
        <property type="gene ID" value="TERMP_00520"/>
    </dbReference>
    <dbReference type="GeneID" id="10040838"/>
    <dbReference type="KEGG" id="tba:TERMP_00520"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.520"/>
    <dbReference type="HOGENOM" id="CLU_165264_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="115" mass="13410" checksum="91467C897C8A2058" modified="2011-05-03" version="1">MDEEPKKIAKIVDELVTFCLRHGAKKLSIHIEDEGDAFRIHLHVDRINRDDPLVKELTKLLSLPKHDEISEYYWTLVGEVEEDTELSVIGMMTDRAEIKFKNNSVSLTLYRKKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJW3</accession>
    <name>F0LJW3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT83500">
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    </dbReference>
    <dbReference type="GeneID" id="10040841"/>
    <dbReference type="KEGG" id="tba:TERMP_00523"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.523"/>
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    </dbReference>
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    <dbReference type="OMA" id="NFGECIA"/>
    <dbReference type="OrthoDB" id="102836at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="348" mass="39353" checksum="F337EBC72BC2FD8B" modified="2011-05-03" version="1">MRKIFLPLLLLILPLVTPAPTISVAFCSSGFRIIVAPTTSGVIYVGAGLYDLKPQNFGECIAMFDPPTQYARFYLVNSSDAYYLGGYYEYGTENRTLNEVLSTVERNVVPVLGNHSGDYVIFSFKNGTYKIPVKELMFYLWSDSLLDHLVAFPSGMGIVIVPAVEIDAIESNFTIMRKPGKQVDKTLIVFNVTYHVFIGYLIMINGTAIRWETQKVDRMNLTWDELSEMFNKPLYAFYFDGKTLKSYPLIKVKLSWIGNAFHLSPKYEFINLAPSYEHMTTQKEIKTKTLSPNLISETFSTSIHSTNLTSSPLTNHTVQNSKSEIPKLTSLLLILLVVISVSLFLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJX6</accession>
    <name>F0LJX6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfhydrogenase II subunit a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00536"/>
    <dbReference type="EnsemblBacteria" id="ADT83513">
        <property type="protein sequence ID" value="ADT83513"/>
        <property type="gene ID" value="TERMP_00536"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00536"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.537"/>
    <dbReference type="eggNOG" id="arCOG01549">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044556_0_0_2"/>
    <dbReference type="OMA" id="QNNLAMN"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00508">
        <property type="entry name" value="NI_HGENASE_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="426" mass="48621" checksum="CBB1FD5F23E86C97" modified="2011-05-03" version="1">MYIPITVDHIARVEGKGGIEIVMGDEGVKEVKLNIIEGPRFFEAITIGKKLDEALAVYPRICSFCSAAHKLTALEAAEKAIGFTPREEIQKLRELLYIGDMIESHALHLYLLVLPDYLGYPDPLSMIDRYKREVEYAMKLKNIGSKIMDVLGSRAIHQENAILGGFGKLPSRAQFEELRRELKEILPLAEYTVELFAKLEQFSEVDDEENVHMAIKPRGGIYGIYGDYVKVSDGFEFPVEDYKKWIVERVVEHSFAKHSFYKGKPFMVGAISRIVNNADLLYGRAKALYEKYRDLFRYDNCFANNLAQALELVYFTEKAVDIIDETLARWPIRERDAVEIKDGFGVSITEAPRGLLVYALEVKNGRVSYADIITPTAMNLAIMERHVRMMAEKHYQDDPDRLKFLSEMVVRAFDPCISCSVHIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJZ6</accession>
    <name>F0LJZ6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_00556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00556"/>
    <dbReference type="EnsemblBacteria" id="ADT83533">
        <property type="protein sequence ID" value="ADT83533"/>
        <property type="gene ID" value="TERMP_00556"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00556"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.557"/>
    <dbReference type="eggNOG" id="arCOG00954">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1375532_0_0_2"/>
    <dbReference type="OMA" id="NFIRYAH"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT83533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="188" mass="21522" checksum="B4F42ECB8827F664" modified="2011-05-03" version="1">MSIEEVVRILKENGVKLAFFGGGEPTIDRELKPLIKQLKKEGISVWLITNGELLDKELVELVKGVTFSIKAFDDELHKRITGVSNYKVLENFKRFAKSGKIVAETVYVKGIVECDEILKIAKFIASLNPKIRFRIDPLVQNPIYEEVDECIRKVRRILPNTYRIRGTGKGEPPNLLYPEVSKIWEKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK01</accession>
    <name>F0LK01_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine-5'-monophosphate dehydrogenase-like protein I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466836.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00561"/>
    <dbReference type="EnsemblBacteria" id="ADT83538">
        <property type="protein sequence ID" value="ADT83538"/>
        <property type="gene ID" value="TERMP_00561"/>
    </dbReference>
    <dbReference type="GeneID" id="26135897"/>
    <dbReference type="KEGG" id="tba:TERMP_00561"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.562"/>
    <dbReference type="eggNOG" id="arCOG00608">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116133_0_0_2"/>
    <dbReference type="OMA" id="HYKAVMI"/>
    <dbReference type="OrthoDB" id="102704at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017158">
        <property type="entry name" value="Tscrpt-reg_CBS-contain_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037253">
        <property type="entry name" value="HTH_CBS_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="74"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="186" mass="21229" checksum="AFC96BFF6AD1592E" modified="2011-05-03" version="1">MVILPRPIDPREIRRIRKELGITQEELAKRAGVTQAYIAKLESGKVDPRLSTFNRILEALLQCKKAQLKAKDVMSSPIIAVKPYDQVDKIIKLMNEHNISQVPVIAGNKVVGSVTEKTLVRKSLEYEDIYERKAMEVMEEPFPIVNEEEDIEVVKYLLEEHPAVIVQNKEGKPVGIITRSDLFRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK28</accession>
    <name>F0LK28_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FeMo cofactor biosynthesis protein NifB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nitrogenase cofactor maturase NifB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Radical SAM assemblase NifB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">TERMP_01765</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; Fe-Mo cofactor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. NifB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01765"/>
    <dbReference type="EnsemblBacteria" id="ADT84740">
        <property type="protein sequence ID" value="ADT84740"/>
        <property type="gene ID" value="TERMP_01765"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01765"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1764"/>
    <dbReference type="eggNOG" id="arCOG00945">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_3_1_2"/>
    <dbReference type="OMA" id="PTEACNF"/>
    <dbReference type="UniPathway" id="UPA00782"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005980">
        <property type="entry name" value="Nase_CF_NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43787:SF3">
        <property type="entry name" value="PTHR43787:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01384">
        <property type="entry name" value="thioether_bond_formation_requi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="130"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADT84740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="516" mass="59825" checksum="438C72076472BEEB" modified="2011-05-03" version="1">MKVIVCVIKHPSPLYFLMDNTPHILPHIVGVRRKEDMMGKENISQYKPSFYNLIIPLNEEGEFVLFNTLRNIVARIDRETKEGLETGSLERLDNETITRMRETGVIIPKNLDELDYLKYLRILHLGNMLANSRVGLTLVMTYSCNLACPYCYEGDRKTKGGLLTPKKIDKILTFAKNHEQNDKKPIVSISFYGGEPLLNWKGCKYTLKRLKEMKDEGEIRDYSTSFVTNGILINEETIDAINTYNVYSMQITLDGPRDIHDKRRIKINGEGTFDEIIENIKLLKNEVTNEKFRLGLRINVDKTNYKRIPELLDFLKKEGLNDIPISYGIVRSNIPYCSDCSNTHVFLGRDLPEYLPFLWKEAYRRGFKITTRPNLKFVYCVYDNPNGYVVDPELKVYPCWEMVGAEKYIIGKIKEEGSFEPEPFYYTVKTRNPIEFEECKNCKLLPICMGGCAAESTRRNGHPNGPGCDITKYVWKEGLKFYLMRKYPNLFTNKELTEILGTVPMEENSNMLKFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK44</accession>
    <name>F0LK44_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468052.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01781"/>
    <dbReference type="EnsemblBacteria" id="ADT84756">
        <property type="protein sequence ID" value="ADT84756"/>
        <property type="gene ID" value="TERMP_01781"/>
    </dbReference>
    <dbReference type="GeneID" id="10042097"/>
    <dbReference type="KEGG" id="tba:TERMP_01781"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1780"/>
    <dbReference type="eggNOG" id="arCOG00730">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140143_0_0_2"/>
    <dbReference type="OMA" id="TDDKGMH"/>
    <dbReference type="OrthoDB" id="115996at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="159" mass="17741" checksum="19DBAB525AFDC2ED" modified="2011-05-03" version="1">MGVILDSSVILKALLSPSRNLPEKVYNRERQTHEKCKYLMRLIEERNIEVHVPTVAKVEVAGVIKRVTGDADKALLAAITISENYNLHYDVELIEKALEISLSTGASGFDSYFIALANLLNLPLFTDDKGMHIKAMGMGIKSYLIRELTIDDIKGFFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK47</accession>
    <name>F0LK47_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468055.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01784"/>
    <dbReference type="EnsemblBacteria" id="ADT84759">
        <property type="protein sequence ID" value="ADT84759"/>
        <property type="gene ID" value="TERMP_01784"/>
    </dbReference>
    <dbReference type="GeneID" id="10042100"/>
    <dbReference type="KEGG" id="tba:TERMP_01784"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1783"/>
    <dbReference type="eggNOG" id="arCOG03827">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065737_0_0_2"/>
    <dbReference type="OMA" id="LEVALWM"/>
    <dbReference type="OrthoDB" id="43316at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="359" mass="40232" checksum="3EAE757F28A6F12E" modified="2011-05-03" version="1">MTTIEDILLLVKGGLYEDALLKVDELEDNLDKVHAVSLIALDIYEKFSDINLALDIMEDAEYITKKIKDPFKKSIALSNVASAYLIIGNRKKGVKLFEKALDEALHIENSGERAIALGKISYHMGISGLIDSALETFEVAFDTVIRSKIDYTQKTDYSIKLGEILEETGDSLNSTGALPFYERAYDLFDKLHVNFKAAILEKKILLAKTLKVCGKPEIRSALLEGRYGHAVAEVKNLLKGEKIAIGLLEIALWMKKLDVFEYKKIVREILEQIDAFSYSQEGVAYIATLLTELGSIKEALVFANKIEDVEKKSEALKAIALELAREKELKDAYKIIEIIPDNEIKKKALEEIVEIEATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK63</accession>
    <name>F0LK63_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="7">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">t(6)A37 threonylcarbamoyladenosine biosynthesis protein Kae1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA threonylcarbamoyladenosine biosynthesis protein Kae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">kae1</name>
        <name evidence="9" type="ordered locus">TERMP_01800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="7">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468071.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01800"/>
    <dbReference type="EnsemblBacteria" id="ADT84775">
        <property type="protein sequence ID" value="ADT84775"/>
        <property type="gene ID" value="TERMP_01800"/>
    </dbReference>
    <dbReference type="GeneID" id="10042116"/>
    <dbReference type="KEGG" id="tba:TERMP_01800"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1799"/>
    <dbReference type="eggNOG" id="arCOG01183">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_2_2_2"/>
    <dbReference type="OMA" id="MRIMCEE"/>
    <dbReference type="OrthoDB" id="34679at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022449">
        <property type="entry name" value="Kae1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="PTHR11735:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="8">
        <location>
            <begin position="22"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="127"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT84775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="324" mass="35290" checksum="35F97390CBC762E1" modified="2011-05-03" version="1">MIALGIEGTAHTLGIGIVTEDKVLANVFHTLTTEKGGIHPKEAAEHHAKLMKPLLKKALQKAGISIEDVDVIAFSQGPGLGPCLRVVATAARALAIKYGKPIVGVNHCIAHVEITKMFGVKDPVGLYVSGGNTQVLALEGGRYRVFGETLDIGIGNALDTFAREIGLGFPGGPKIEKLAQKGERYIELPYAVKGMDLSFSGLLTEAVRKFKSGKYRIEDIAYSFQETAFAALVEVTERAVAHTEKEEVVLVGGVAANNRLREMLKIMTEDRGIKFFVPPYDLCRDNGAMIAYTGLLMYKAGVRFKIEDTIVNQKFRTDEVEVIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK64</accession>
    <name>F0LK64_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468072.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01801"/>
    <dbReference type="EnsemblBacteria" id="ADT84776">
        <property type="protein sequence ID" value="ADT84776"/>
        <property type="gene ID" value="TERMP_01801"/>
    </dbReference>
    <dbReference type="GeneID" id="10042117"/>
    <dbReference type="KEGG" id="tba:TERMP_01801"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1800"/>
    <dbReference type="eggNOG" id="arCOG03796">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067022_2_0_2"/>
    <dbReference type="OrthoDB" id="78292at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008553">
        <property type="entry name" value="DUF835"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05763">
        <property type="entry name" value="DUF835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DUF835" evidence="2">
        <location>
            <begin position="124"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="249" mass="28192" checksum="1E9259C3A3BB129A" modified="2011-05-03" version="1">MVGAIVLFYRVFLFLMILFLTIFISIRIRRYPKNLRKLMLLAAIFSGIGAFGRLIDVLVLFVSIPFAYEIHLITHVVSIGGVIWVFISLMLNLERYYIPLTSISHAEEKRKPGASYIVLSSNTLQDVVEFLQNIDGPVLLFTRYPNLYGNENIKKIWITTADSKGVSPTALHVLQDIAIRFASENNGATIVVDCLEYLVLYNGFKSVFKFLVTLKDHLMTRGATLIIFADPTALEESQVALLKREFNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK90</accession>
    <name>F0LK90_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468098.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01827"/>
    <dbReference type="EnsemblBacteria" id="ADT84802">
        <property type="protein sequence ID" value="ADT84802"/>
        <property type="gene ID" value="TERMP_01827"/>
    </dbReference>
    <dbReference type="GeneID" id="10042143"/>
    <dbReference type="KEGG" id="tba:TERMP_01827"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1826"/>
    <dbReference type="eggNOG" id="arCOG04298">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138382_0_0_2"/>
    <dbReference type="OMA" id="FGIAFCE"/>
    <dbReference type="OrthoDB" id="94911at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007153">
        <property type="entry name" value="Adenosine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036902">
        <property type="entry name" value="Ta1353-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36155">
        <property type="entry name" value="PTHR36155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04008">
        <property type="entry name" value="Adenosine_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103165">
        <property type="entry name" value="SSF103165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="162" mass="17691" checksum="7D9034AA86B73CBF" modified="2011-05-03" version="1">MVKIEVVDIEKPEGVECIIGQGNFSIFTVDDLARALLTTVPGIKFGIAMNEAKPQLTRYTGNDRQLEELAAKNAVKIGAGHVFVILMKNAFPINVLNTVKNHPAVAMVYGASENPMQVIVAETELGRAVLGIVDGKAANKIETEEQKKERRELVEKIGYTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK97</accession>
    <name>F0LK97_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyguanosinetriphosphate triphosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00578"/>
    <dbReference type="EnsemblBacteria" id="ADT83555">
        <property type="protein sequence ID" value="ADT83555"/>
        <property type="gene ID" value="TERMP_00578"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00578"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.579"/>
    <dbReference type="eggNOG" id="arCOG04430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026821_3_1_2"/>
    <dbReference type="OMA" id="RRQTPRW"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="52"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="416" mass="47738" checksum="E330C6E7FD72FEFD" modified="2011-05-03" version="1">MDGKIIHDPIHGSMKIKGVILDLVKTPEFQRLRSIRQLGLAYLVYPGANHSRFEHSLGAYNIARRLAQEIELDKDEKTLLEMGALLHDIGHGPFSHTFEQIYKHYVKEYDHMHLGQNIILGKIDIIDGEIESREFIPEIIESYGYSPKEVADLILGKYEKRYLGQMLHGDVDVDQIDYLMRDAHYTGVAHGIIDIERLLKVLKIHEGQLVVDEKGIEAVEGMMVARALMYSRVYFHHTVKIAEGMLTRALEFALEEGHLWDFWKMTDCRVFVELEDLEGYPGEIARRIKYRDIYKAAVLASADELSAEEKKELLSAYRNVKRRQEIERNLADAVGAKEGEVILEFSIADLMLSEPRLKATEINVLLHTGELQPLTKVTPLANALKRRQTPRWAVLIASPAKYVNKVREIWKKVIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKA4</accession>
    <name>F0LKA4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-binding protein MutS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mutS2</name>
        <name evidence="6" type="ordered locus">TERMP_00585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Has ATPase and non-specific DNA-binding activities.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466860.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00585"/>
    <dbReference type="EnsemblBacteria" id="ADT83562">
        <property type="protein sequence ID" value="ADT83562"/>
        <property type="gene ID" value="TERMP_00585"/>
    </dbReference>
    <dbReference type="GeneID" id="10040903"/>
    <dbReference type="KEGG" id="tba:TERMP_00585"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.586"/>
    <dbReference type="eggNOG" id="arCOG02895">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026764_0_0_2"/>
    <dbReference type="OMA" id="HYHAKTQ"/>
    <dbReference type="OrthoDB" id="9037at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00971">
        <property type="entry name" value="MutS2_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012401">
        <property type="entry name" value="DNA-bd_MutS2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029254">
        <property type="entry name" value="MutS_C_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="5">
        <location>
            <begin position="377"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="384"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="565" mass="65011" checksum="C37DBAA172F9C100" modified="2011-05-03" version="1">MRLNSEARAIYKSIREEIKKRIQLKESLAYLDKFEPTNDKKEILRRQTYFKENFPRIVPELKGILAKIEPIRFKKDFLHDRLLVVDESELEKAQALGVCEVSTEPLEGYDLTLSTVGIGIDVELSISEIAPELYIMPLWENRETLKALSQIANLLGEKSVAESILKKLGELEEIMKRRELIENLDELIAEEERRLNKKIAEKLERFSLTLTGKELLEFLKELREGDYGAIFKHFSEIESEILEEINEAEKRLSERLNFTVELFSRENLYPIEVLPESIEALHQELERELKIELYLKSREILDEIKHLIPKLREEINKAYELEFLRAVKEFTEGFTFPELIEGGITFINGRHLFIKNPQPVSYVVGKAPIEFNGVNGERVVILTGANSGGKTSLLELTSQIVILTHMGFPVNAEKAWVEVLDELFFFKRKRSIYGAGAFETALKSFVRALTSDGRKLILIDEFEAITEPGAAVKIIAELLKIAYEKGFYVIIVSHLGEDLKKELPFARVDGIEAQGLDENLNLIVDRQPKFGVLGKSTPELIVEKLYRAKRGKEKKIFERVWRAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKC7</accession>
    <name>F0LKC7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466883.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00608"/>
    <dbReference type="EnsemblBacteria" id="ADT83585">
        <property type="protein sequence ID" value="ADT83585"/>
        <property type="gene ID" value="TERMP_00608"/>
    </dbReference>
    <dbReference type="GeneID" id="10040926"/>
    <dbReference type="KEGG" id="tba:TERMP_00608"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.610"/>
    <dbReference type="eggNOG" id="arCOG01644">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105758_1_1_2"/>
    <dbReference type="OMA" id="LEIVAFF"/>
    <dbReference type="OrthoDB" id="124888at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010397">
        <property type="entry name" value="DUF996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06195">
        <property type="entry name" value="DUF996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019678">
        <property type="entry name" value="UCP019678"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="194" mass="20872" checksum="92EE7DA50C33C9F3" modified="2011-05-03" version="1">MTLSQAKMYGGIGAILALVGGVVPRLGSALSIVGIVLILLAVKEISNETGDEAIFKNYLISFILQIGAFLALIIAIIAVLGTSIIAMGGPRAFEHEMQNFGAIMAIIGSILVGFVIFWIMFSLGSYYLKKSYELIAEHTDVDLFKTTGLLYFIGALTAIILIGLLIIFVARILEIVAYFSLPEELPSKQNSVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKF0</accession>
    <name>F0LKF0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466906.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00631"/>
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        <property type="gene ID" value="TERMP_00631"/>
    </dbReference>
    <dbReference type="GeneID" id="10040949"/>
    <dbReference type="KEGG" id="tba:TERMP_00631"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.633"/>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_14"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="34"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="362" mass="41062" checksum="CE3CA0F3A4806B29" modified="2011-05-03" version="1">MFSTRPVRKEEELFGRKHREAVGRIYNAIQDGDFVAVLGPRRVGKTSVINVFLNKYGSEFYYLYYDLAFGMGREAISYLELTPVRTNIPTKVLDYSASLNFGILRMDIRPRGIVEFQNAFIGLLRFLNRTGKQTVIVFDEAQVLPRFTPLNMLGILQTISDSFENVTVILSGSMPGLLERVINPSGERPFFARYVERVNITRWSTEEGLEYLKLGLPSVELEELKEAVIELSGVPGFLAYYGKLRTRGLFHSEALEETVKYAIRLWTLDLQNFLRIYRSPGYIVALQRVAKGPSTGVTTEEIIAEVKATTGLSGVRIKNMLRNLVDAGLLVKPRRGLYVIPERPLRKAVLSFKGNFSNPRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKG1</accession>
    <name>F0LKG1_THEBM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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    <dbReference type="EnsemblBacteria" id="ADT83619">
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    </dbReference>
    <dbReference type="GeneID" id="10040960"/>
    <dbReference type="KEGG" id="tba:TERMP_00642"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018646">
        <property type="entry name" value="12TM_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09847">
        <property type="entry name" value="12TM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018875">
        <property type="entry name" value="UCP018875_ABC_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="493" mass="55511" checksum="394EC1C2C2D7A203" modified="2011-05-03" version="1">MFEVVKILYRELHYQILKRNPQIANDEKKFKKHLKNAVSIKRNVAIQSIAFIFFGIMMAIGLFFSDDKTYIVAMLSSLALIPFIFSLYVTTVQSSYVVSLGLFEPMKSLPIRIGALYLSELLGIDQIPALAMILPSIAVVSMRYPLNGILALLWVFVGMLAGHTIGLIIYSTFGLRISYRKSRSGSLKNLLKILAIFAFMGLFYGVSYMQGYIQEHSEKVAAVIGRYSIAYPFTISSIFDPKKSVVMLLLYVAVFIPLYQLALKRVWSGILEPKLESEKTKTSKFRASLGGKVLNLTLKDLKIIFRKTAMITGFLMPIYVLLPQILMTIQSGNLSIMRATYFLFILGVFTIPGADAVLKVEGKVLDFLKSLPLTKREYALSKALSMSVIPMLLSGLILILAVYYDPKALILFPYIFLLPLNASFLTMAYFFRYEEVELGIPEFNIGHMIVLMILVGMLFGVITLPLFLLTYPLEYFISFGIGLVSLGILYRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKJ3</accession>
    <name>F0LKJ3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">TERMP_01852</name>
    </gene>
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        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
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            <taxon>Euryarchaeota</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ADT84827">
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        <property type="gene ID" value="TERMP_01852"/>
    </dbReference>
    <dbReference type="GeneID" id="10042168"/>
    <dbReference type="KEGG" id="tba:TERMP_01852"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1851"/>
    <dbReference type="eggNOG" id="arCOG10067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1088288_0_0_2"/>
    <dbReference type="OMA" id="KFDIYTN"/>
    <dbReference type="OrthoDB" id="51655at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="280" mass="33267" checksum="7411C70CC9BDDF4D" modified="2011-05-03" version="1">MKRLELSDDIFLEVYDLRSYNNDAIRESISAMFKIADELRGKVVLVGGWSVYYWVDNVLDYNGVPSIDIDFLAKAESFEEIREVMKNLGFQSAGFRFAKPLKRLIVREEVKVDFLFDEKPSQLSFDTPFASSIFRNRYYSRVNFEVRDFNKNLIAGGEIDVAFPEAVLALKFDIYTNLGDYPDDKRDKHWKDIIDVYSLVMGFYKKRNAWREKDFYLRKDILRELYKAKSYKPTSIYEVLKESQYKEDIRVMLADYVGFRVFEEKLFERKLRELETIIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKN8</accession>
    <name>F0LKN8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_01897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468168.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01897"/>
    <dbReference type="EnsemblBacteria" id="ADT84872">
        <property type="protein sequence ID" value="ADT84872"/>
        <property type="gene ID" value="TERMP_01897"/>
    </dbReference>
    <dbReference type="GeneID" id="10042213"/>
    <dbReference type="KEGG" id="tba:TERMP_01897"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1896"/>
    <dbReference type="eggNOG" id="arCOG03421">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_541456_0_0_2"/>
    <dbReference type="OMA" id="TNLMALP"/>
    <dbReference type="OrthoDB" id="38792at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007509">
        <property type="entry name" value="DUF515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04415">
        <property type="entry name" value="DUF515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="471" mass="53187" checksum="3FE14383921BCEF6" modified="2011-05-03" version="1">MSEDIEAKIRRLRELGKATAEQEARPPKPAVTRPPRRVSKIGSLRERERKRRIIIGAAIVIIILLAISFAAYTYYQNRTLRELEKAKQQKIAEVNRYFTGELANDTAKFELIKQIQAAKSIEELNKIDVKKVYEERLAELQRRKEEEAKKKALEELNKAKAQQISAIEQAFEPLLAQPLPEDLKNKAIKKLNQLKQEVENAQSKEQVLAVDPTPYLMDLWKEYYYYLIDSIPTQKVILKKGEEKRIYTKIEAKYVISKITDLGELLQYTIEKAEMVQIALVLTRDRINGAFLSPGDKIKIYAKNGTKGQYIKIADEGYVDLVLLPTTAGQISLSESQSEGSTVSTSSTTSYSESHSTSYTPGDTTITNAQNANNQYSTTQSSSDSSSAYYNYNVNLAEVLKAIAAGKIEAPEDVKEQLSQYGWKIIDLEKDSGMLVLDPTARFLVIIEVPAEFVTDILNHKDMIYIAKITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKP9</accession>
    <name>F0LKP9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468179.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01908"/>
    <dbReference type="EnsemblBacteria" id="ADT84883">
        <property type="protein sequence ID" value="ADT84883"/>
        <property type="gene ID" value="TERMP_01908"/>
    </dbReference>
    <dbReference type="GeneID" id="10042224"/>
    <dbReference type="KEGG" id="tba:TERMP_01908"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1907"/>
    <dbReference type="eggNOG" id="arCOG02742">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052321_2_0_2"/>
    <dbReference type="OMA" id="YRDMATV"/>
    <dbReference type="OrthoDB" id="95312at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="192"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="412" mass="47385" checksum="D5D5B1C3E332D386" modified="2011-05-03" version="1">MERKFQPTGKAEQLLLALWLSVMVAFFMLRWDMIYLTLPMLWLFFVAMTFFKPRLDVEIKRILPHDRILEGSEIEIRLKIKANERIPSLKIADDLPKGLELVEGKNEFLLSFTRGEEKEVSYKVKVKRGIHEFNFIKLSYQDPFGFFKIEKIIDLYDELIGVPIVEDVVTPYSTKGTKVTVGPLPSPRIGEGVEFHAIREYQPGDPLKIINWKATAKTGKIMSNEYESERKVDVILIVDATYKGESTFDHLIRAAASFMLDCLNSGTSFGLLLAEDVPLWIRVDYGKRHFFKCIDFLSMAKPDKNNMIAYQVEHLVRSRFPARAQILYFSPLITEEGREALKVLYRYGYKVVVISPDPYSALKPKSVEEALALKILQLKRKAHLRKLAAYGIIIDWDVNKSLKTAIAEVVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKZ1</accession>
    <name>F0LKZ1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-type ATP pyrophosphatase</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">TERMP_01923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01923"/>
    <dbReference type="EnsemblBacteria" id="ADT84898">
        <property type="protein sequence ID" value="ADT84898"/>
        <property type="gene ID" value="TERMP_01923"/>
    </dbReference>
    <dbReference type="GeneID" id="26137459"/>
    <dbReference type="KEGG" id="tba:TERMP_01923"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1922"/>
    <dbReference type="eggNOG" id="arCOG00042">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_1_1_2"/>
    <dbReference type="OMA" id="MNLDQKQ"/>
    <dbReference type="OrthoDB" id="57500at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00269">
        <property type="entry name" value="TIGR00269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="50"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="321" mass="37107" checksum="D8313C079284CEC5" modified="2011-05-03" version="1">MKCSKCGREAVYHARYEGKYYCHKHFNEMVEKKVKQTVRKYRMIKRGERIAVGVSGGKDSVVLLHLLAKLRKKFPFEIVAITIDEGIEGYRPPSVEIAKKNAELLGIEHHVYSFKEYIGFTLDETVQIMGSFEKGERVGACSYCGVWRRWLLNYAAQDVQADKLAIGLNLDDEAQVFLMNIMRGDIARLGRTGPYYEVIHEDLVPRIKPLREVPEKEIVLYAVLNNIEVDFSECPYAVEAFRAEIRDWLNEMEEKHPGTKYQILRSYDKLFPILAKHYAKRELNRCKICGQPTTGEICKACQFKLQVQKKAKELGLTFKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL01</accession>
    <name>F0LL01_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Choline-sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01933"/>
    <dbReference type="EnsemblBacteria" id="ADT84908">
        <property type="protein sequence ID" value="ADT84908"/>
        <property type="gene ID" value="TERMP_01933"/>
    </dbReference>
    <dbReference type="GeneID" id="10042249"/>
    <dbReference type="KEGG" id="tba:TERMP_01933"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1932"/>
    <dbReference type="eggNOG" id="arCOG02785">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_14_1_2"/>
    <dbReference type="OMA" id="IRTYHDG"/>
    <dbReference type="OrthoDB" id="25689at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
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        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="2">
        <location>
            <begin position="347"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="462" mass="54433" checksum="8CC4E170C81AD19E" modified="2011-05-03" version="1">MADNEIKKVLLITIDCFRGDHLHYNGYGRKITPTMDMLAKKGSNFFMAFSNGPHTHYSFPSILTSTYPLMFEGPKIGAGRITLAEVMKMLGFKTVGLNSNPFLSEYFGYGKGFDVFNDFLSGERAKKKSTMMVKLRRKFSDKSMLYKFLRFVDKYMAVKKRRTPYVPAEELRSRVIDYLKRYRDEKLFLWAHFMDAHYPYLPSRETMEELGFEDVNDFKKARLFTKMLNAPEKVTPEEVQILINLYDAQIYTVDQEIREIFEYLDENGLLEETLIVITADHGEEFGEHGDFTHRVDRDRPALYNVHIHVPLIFYSGNWEYDDVNKNVSLIDLAPTIVDLVASQKVKKFMGRSLVPLMSKEESDHRAFYSEHEYQESEIVGNIMKERRKAIAYIEYPYKLIYYEGDSSYQLYNFEEDPEERNNLINEPNYQKVALYMKEKIKEHLREIEMSKVRIKMKKLKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL15</accession>
    <name>F0LL15_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01947"/>
    <dbReference type="EnsemblBacteria" id="ADT84922">
        <property type="protein sequence ID" value="ADT84922"/>
        <property type="gene ID" value="TERMP_01947"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01947"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1946"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_10_0_2"/>
    <dbReference type="OMA" id="HNIRYIS"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="46"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="124"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="179" mass="20727" checksum="FBC30B9D27DCB767" modified="2011-05-03" version="1">MERAEKLKRKKMHIVVGKRKHLQMQRKEELSHNIRYISKVPVKLVMDTDFLKVHPEDPLTTLIENLKGEETSAVVVDEKNRLLGFITMKDLLHFFSPPRRYSIVGLGLLKRYTLNRASRVEDIMVTKPITIHIDDNLGHAIKLMIETGKHHLPVVDGEKHVHGILEVKDIIRLIRIVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL63</accession>
    <name>F0LL63_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TrmB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467012.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00737"/>
    <dbReference type="EnsemblBacteria" id="ADT83714">
        <property type="protein sequence ID" value="ADT83714"/>
        <property type="gene ID" value="TERMP_00737"/>
    </dbReference>
    <dbReference type="GeneID" id="10041055"/>
    <dbReference type="KEGG" id="tba:TERMP_00737"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.739"/>
    <dbReference type="eggNOG" id="arCOG00374">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079811_0_0_2"/>
    <dbReference type="OMA" id="KKKRENW"/>
    <dbReference type="OrthoDB" id="123314at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="TrmB" evidence="3">
        <location>
            <begin position="246"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="313" mass="34443" checksum="D70024CDA6AD7C0D" modified="2011-05-03" version="1">MRSKAAIVLAIALMILPFISGQYSVESLSLTVYSDGYVKVSEVIIPENYTVSFSISLLATNVEGLTVIDENGNPLPYKINGSILTVYFENAIPIKITYYTPDLTSKKGAIWSVHFSSTIPVKITFPDNAVIVDLTDIPLEINGNSILMPPGNQTVSYVLEYRPVGTEAPAAPTLGTTTKSFNSTVPSSPGSSSQSSSTSSEGSMNWTMVGILTLLALAAGGGFVYMRRGGGEKAIGISREDFERRLKEYELTKDEEKALLYLFDRGGKAKQAEVREMLGIPKTTAWRMFQRLEKQGLVRVYKKKRENWVELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL78</accession>
    <name>F0LL78_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NusA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467027.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00752"/>
    <dbReference type="EnsemblBacteria" id="ADT83729">
        <property type="protein sequence ID" value="ADT83729"/>
        <property type="gene ID" value="TERMP_00752"/>
    </dbReference>
    <dbReference type="GeneID" id="26136204"/>
    <dbReference type="KEGG" id="tba:TERMP_00752"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.754"/>
    <dbReference type="eggNOG" id="arCOG01761">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132460_0_0_2"/>
    <dbReference type="OMA" id="MKAPICE"/>
    <dbReference type="OrthoDB" id="82272at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="KH_5" evidence="6">
        <location>
            <begin position="57"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="170" mass="18899" checksum="BC881B43FF1BA5F1" modified="2011-05-03" version="1">MKAPICEVCLKTDDILCPADEKKLQEGVISELDVKIARLLYKLLGDADIEFKRAVEAGDLIVIMVGEGDVPLTIGKGGKNIKLLMRELGKRIRVIEGREIKGTDDVKKLATDLFYPASIFGVNIVYKPNGGQYYKVLVLQRDKNKLPEKPEVLENILTQITGKDSKIAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL82</accession>
    <name>F0LL82_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glyceraldehyde 3-phosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467031.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00756"/>
    <dbReference type="EnsemblBacteria" id="ADT83733">
        <property type="protein sequence ID" value="ADT83733"/>
        <property type="gene ID" value="TERMP_00756"/>
    </dbReference>
    <dbReference type="GeneID" id="10041074"/>
    <dbReference type="KEGG" id="tba:TERMP_00756"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.758"/>
    <dbReference type="eggNOG" id="arCOG02291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_3_2"/>
    <dbReference type="OMA" id="FPIATRV"/>
    <dbReference type="OrthoDB" id="93004at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011950">
        <property type="entry name" value="HAD-SF_hydro_IA_CTE7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02253">
        <property type="entry name" value="CTE7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="214" mass="25433" checksum="9C8BA6AA2AA0E651" modified="2011-05-03" version="1">MEAILFDVDETLLTEKPLMMLFLPQVYEEISRRLQIRKEEARAKFLEEILSRRNTYEWHDWNFFFRLFNLDLRYEELLIAYPHKIHVFPDVKPTLEWLKSEGYKLGVVTSGPTYQKLKLRIAKLDNYFDVIVTREDVNTIKPDPKIFIYALEKLKVEPKEAIMIGDSLQQDVYGAKNVGMIAVWINRNNEKGYNFADYEIRTLHELRKILGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL83</accession>
    <name>F0LL83_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467032.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00757"/>
    <dbReference type="EnsemblBacteria" id="ADT83734">
        <property type="protein sequence ID" value="ADT83734"/>
        <property type="gene ID" value="TERMP_00757"/>
    </dbReference>
    <dbReference type="GeneID" id="10041075"/>
    <dbReference type="KEGG" id="tba:TERMP_00757"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.759"/>
    <dbReference type="eggNOG" id="arCOG02203">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1068009_0_0_2"/>
    <dbReference type="OMA" id="GIWERGL"/>
    <dbReference type="OrthoDB" id="57927at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="260" mass="30263" checksum="9AF53ECE94ABA427" modified="2011-05-03" version="1">MISFTHIFVGIGNSGIRIVRNIDIPNAVKVPLDSSYYLFDKKRHSFVKQIKSFFGSLSDDTIIWIIFEDKPINIEIVRLINDALTKDVIRLAYVLSPYKELVHEERPEWAYSFETVFYDSLSEFLSTYTAIPLEDAFNAASKQIGLMFSKLYYYLENQMLVNIDYADLFNMIKGGNIGILRILRDVNFEWNWGIWDRGLISIMVGKNVPLKNAHEILEKFQHLLREKDIIWGVRMNKELDNEIEILALLIKRWSNGGNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LL84</accession>
    <name>F0LL84_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-hexulose-6-phosphate synthase</fullName>
            <ecNumber evidence="5">4.1.2.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_00758</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:25201"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58542"/>
            <dbReference type="EC" id="4.1.2.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; formaldehyde assimilation via RuMP pathway; D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HPS/KGPDC family. HPS subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SIS family. PHI subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.43" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00758"/>
    <dbReference type="EnsemblBacteria" id="ADT83735">
        <property type="protein sequence ID" value="ADT83735"/>
        <property type="gene ID" value="TERMP_00758"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00758"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.760"/>
    <dbReference type="eggNOG" id="arCOG00053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709423_0_0_2"/>
    <dbReference type="OMA" id="AMIGANK"/>
    <dbReference type="UniPathway" id="UPA00294">
        <property type="reaction ID" value="UER00434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043801">
        <property type="term" value="F:hexulose-6-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019647">
        <property type="term" value="P:formaldehyde assimilation via ribulose monophosphate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04726">
        <property type="entry name" value="KGPDC_HPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05005">
        <property type="entry name" value="SIS_PHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017553">
        <property type="entry name" value="3-hexulose-6-phosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041710">
        <property type="entry name" value="HPS/KGPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017552">
        <property type="entry name" value="PHI/rmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43443">
        <property type="entry name" value="PTHR43443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03128">
        <property type="entry name" value="RuMP_HxlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03127">
        <property type="entry name" value="RuMP_HxlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="8">
        <location>
            <begin position="270"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="435" mass="47980" checksum="1B39596D1EE84BCE" modified="2011-05-03" version="1">MSKILRVKVKKCAIDVKVEALRKYSEEFKMILQVALDLTDIEQAISIAEKAARGGAHWLEVGTPLIKKEGMRAVELMKRRFPDRKIVADLKTMDTGALEVEMAARHGADVVSILGVADNKTIRDALMVARKYGIKVMVDLIGVKDKVKRAKELEKMGVHYILVHTGIDEQAQGKSPLEDLEKVVKAVKIPVAVAGGLNLETIPKVIELGATIIIVGGAITKSENPEEVTRRIIDLFWDEYMQTIRKAMHDITEHIDHVADALRLEEVRGMVDAMIGANKIFIYGAGRSGLVGKAFAMRLMHLDFNVYVVGETITPAFEEGDLLIAISGSGETRTIVDAAEIAKKQGGKVVAITSYKNSTLGKLADVVVEIPGRAKTDVPTDYIARQMLTQYKWIAPMGTLFEDSTMVFLDGIIALLMATFQKTEKDMKRKHATLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLB4</accession>
    <name>F0LLB4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="5">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">TERMP_00788</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>W-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60537"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="5"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467063.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00788"/>
    <dbReference type="EnsemblBacteria" id="ADT83765">
        <property type="protein sequence ID" value="ADT83765"/>
        <property type="gene ID" value="TERMP_00788"/>
    </dbReference>
    <dbReference type="GeneID" id="10041106"/>
    <dbReference type="KEGG" id="tba:TERMP_00788"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.790"/>
    <dbReference type="eggNOG" id="arCOG00707">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_2"/>
    <dbReference type="OMA" id="AHHKDAW"/>
    <dbReference type="OrthoDB" id="9593at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0826">Tungsten</keyword>
    <feature type="domain" description="AFOR_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT83765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="620" mass="68698" checksum="FE51053984912768" modified="2011-05-03" version="1">MKGWWGRILRVDLTNNKVKVQEYSPEIAQLFIGGRGLAAKILWDEVKGVDPLSPENKLVIAAGPFNGLPTPSGGKLVVAAKSPLTGGYGDGNIGTMATVHLRKAGYDAIVIEGKAKKPVYLYVEDDNVSILSAEGLWGLDTFKTEEELKKIHGKNVGILSIGPGGENLVKYAVIMSQEGRAGGRPGIGAVMGSKKLKAVVIKGTKEIPVADKEELRKLSKEAYDEILSKPTYEFWHRQGTMAAVEWTNENSALPTYNFQDGSFKFARSIDGYTLEGMKVKQRGCPYCNMPCGNVVLDAEGLESELDYENVALLGSNLGIGQLNKVAVLNRLADMYGLDTISLGGSIAFVMEAVEKGLLKEGPTFGDYKGAKELVKEIAFRSSELGNFAAEGVMRMAQKVEGGENFAMHVKGLEVSGYNSYIYPAMALAFATSSIGAHHKEAWVIAWEIGTAPIEGEQAKKVEYKITYSPEKAAKVIELQRYRGGLFEMLSACRLPWIEVGLSIDYYPKLLKAITGVTYTWDDLFAAADRLYALIRAYWVREFNGNWSRRMDYPPKRWFIEGLKSGPYKGKHLEEDKYDKLLSEYYKMRGWDERGIPTKETLQKLKLDFVIPELEKVTELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLI5</accession>
    <name>F0LLI5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_02040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468310.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02040"/>
    <dbReference type="EnsemblBacteria" id="ADT85014">
        <property type="protein sequence ID" value="ADT85014"/>
        <property type="gene ID" value="TERMP_02040"/>
    </dbReference>
    <dbReference type="GeneID" id="10042355"/>
    <dbReference type="KEGG" id="tba:TERMP_02040"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2037"/>
    <dbReference type="eggNOG" id="arCOG04346">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065084_0_0_2"/>
    <dbReference type="OMA" id="PEYTVCG"/>
    <dbReference type="OrthoDB" id="21169at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006188">
        <property type="term" value="P:IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023656">
        <property type="entry name" value="IMP_biosynth_PurP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009720">
        <property type="entry name" value="IMP_biosynth_PurP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010672">
        <property type="entry name" value="IMP_biosynth_PurP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38147">
        <property type="entry name" value="PTHR38147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06849">
        <property type="entry name" value="DUF1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06973">
        <property type="entry name" value="DUF1297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004602">
        <property type="entry name" value="ATPgrasp_PurP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1246" evidence="3">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1297" evidence="4">
        <location>
            <begin position="188"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT85014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="379" mass="43927" checksum="A4DA650789504069" modified="2011-05-03" version="1">MIMREQILEVLERYDKENIRIGAIGSHSALDIADGAKEEGFKTLIVSQKGRHRTYAHYFKEKRTKDGLTKGFIDEVIILEKFAKIIEIQEELRRKNVIFVPNRSFVVYTGIDKVENEFLIPLFGSRNLLRSEERSEEKSYYWLLEKAGLPYPEKIENPKDINELVIVKLPHAKKRLERGFFTAASYKEFREKAERLIKLGIITKEDLAKARIEKYIIGPVFNFDFFYSPIDEEIELLGIDWRFETSLDGHVRLPAHQQLTLPEHQFEPEYTVCGHASSTLRESLLEKVFDMAEKYVEATQKYYPPGIIGPFTLQTALDKDLNFYIYDVAPRTGGGTNIHMAMGHPYGNALWRKSMSTGRRIALEIKRAVELDELEKVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLP8</accession>
    <name>F0LLP8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467123.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00848"/>
    <dbReference type="EnsemblBacteria" id="ADT83825">
        <property type="protein sequence ID" value="ADT83825"/>
        <property type="gene ID" value="TERMP_00848"/>
    </dbReference>
    <dbReference type="GeneID" id="10041166"/>
    <dbReference type="KEGG" id="tba:TERMP_00848"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.851"/>
    <dbReference type="eggNOG" id="arCOG01000">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_2_2"/>
    <dbReference type="OMA" id="ANMARTF"/>
    <dbReference type="OrthoDB" id="28553at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="149"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="365" mass="41749" checksum="8E8B327D5B2823BB" modified="2011-05-03" version="1">MREKAEIFKKRVEKFQRLLKENEIDGAVIRTLSTFIYFTGTKWLRPSLLIPAEGEPVVIVAKGEKELFMQKSWIENVKEFQKTEDLMAMVTMWIAKNGYSTIGMEFSIERDAYILFYELFKKLNPGVQIEDIRHLSMQLRMIKDDWELENIRKAGKIAVKGMEVAMEEIKPGKSELEIAAEIYRELMLNGSEDPKVYVSATPRAHAEPFRDVRVEKGRFVTVVIGADYNHYYANLTRSFFIGEPNERAKNAIEAMEEVHKIALEKTLPGVTFSRVERDIAAVYREKGLQEYYITGYTHGVGLLIEEDPITTIVVPHRAMKAREGMALAIVHAPLMVPEGAVKKEDTVILGKKVENVTPFEAPVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLQ3</accession>
    <name>F0LLQ3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase chain I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TERMP_00853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467128.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00853"/>
    <dbReference type="EnsemblBacteria" id="ADT83830">
        <property type="protein sequence ID" value="ADT83830"/>
        <property type="gene ID" value="TERMP_00853"/>
    </dbReference>
    <dbReference type="GeneID" id="26136302"/>
    <dbReference type="KEGG" id="tba:TERMP_00853"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.856"/>
    <dbReference type="eggNOG" id="arCOG01543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1318581_0_0_2"/>
    <dbReference type="OMA" id="RAIEMTW"/>
    <dbReference type="OrthoDB" id="108931at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT83830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="213" mass="24800" checksum="15D01A71504EE051" modified="2011-05-03" version="1">MEEIDFKVAPESKIKKKPSYIKPWLGLKYLFKKPVTIKIPYEKTQIAEKYRGFHSLDWKKCIGCNFCGQICPARAIEMTWIEVNGKAEKRPHPKIDYGRCTFCQFCVDVCPTGALGFVSNYMLTTEWREEELLLYDWVPIHPDKIKEINEKYPDYRFPVSKIEFNKETKEVTYYLRDGEVFKFRILGYGVRPPAAAKPKPAAPKTGEAKKEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLR2</accession>
    <name>F0LLR2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF4040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TERMP_00862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00862"/>
    <dbReference type="EnsemblBacteria" id="ADT83839">
        <property type="protein sequence ID" value="ADT83839"/>
        <property type="gene ID" value="TERMP_00862"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00862"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.865"/>
    <dbReference type="eggNOG" id="arCOG03076">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173139_2_0_2"/>
    <dbReference type="OMA" id="ILAVEWR"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="8">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="94" mass="10406" checksum="EB22C5C9F89ED3D9" modified="2011-05-03" version="1">MINCVQCIEYLIVILMIVSAIFAVEWRDLLAAVVGMAAVSLFASIAFFLLQAPDVAMVEAAIGAAMSAAVFIFAIKRTERYESEEEGTGWWVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLT9</accession>
    <name>F0LLT9_THEBM</name>
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        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
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        <name evidence="2" type="ordered locus">TERMP_02064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468334.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02064"/>
    <dbReference type="EnsemblBacteria" id="ADT85038">
        <property type="protein sequence ID" value="ADT85038"/>
        <property type="gene ID" value="TERMP_02064"/>
    </dbReference>
    <dbReference type="GeneID" id="10042379"/>
    <dbReference type="KEGG" id="tba:TERMP_02064"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2061"/>
    <dbReference type="eggNOG" id="arCOG09755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1286382_0_0_2"/>
    <dbReference type="OrthoDB" id="86168at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="204" mass="24046" checksum="6A62092D656DED9C" modified="2011-05-03" version="1">MLGTSIKKFNEIKRIAKEIANIYPHIFDVVLYGSTVRGKENPRDLDIIILYRDIKKQDREYYKIPFEFRKKLIELGYSREELDVKGIAIWELFDPNFFASLGILAEGYSLLHEKFLHELLNGEAYAMFLYKLPKDWTHNELNKFLHALKGRDGKSGVLGELGGLYLSRGVVLMPIWNTERFKRFLERWNVKYEYSLIIKTTTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLW4</accession>
    <name>F0LLW4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468359.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02089"/>
    <dbReference type="EnsemblBacteria" id="ADT85063">
        <property type="protein sequence ID" value="ADT85063"/>
        <property type="gene ID" value="TERMP_02089"/>
    </dbReference>
    <dbReference type="GeneID" id="10042404"/>
    <dbReference type="KEGG" id="tba:TERMP_02089"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2086"/>
    <dbReference type="eggNOG" id="arCOG01367">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_1_2_2"/>
    <dbReference type="OMA" id="AGETTWH"/>
    <dbReference type="OrthoDB" id="43377at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="1">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="283" mass="31933" checksum="3690E1B75ED5ABBD" modified="2011-05-03" version="1">MRVAVIGANGQLGTDLVEVFGEEAIPLTHKDLDVTDFGSLKILKELKPDVIINTAAYVRVDDAELYPEKAFQVNAIGALNVAKIANEIDAVNVYISTDYVFDGTKGKPYIEEDVPNPINVYGLSKYAGEIFTKNYSGRYYIIRVASLYGKAGASGKGGNFVEFMIQKAKKGENIRVVKDMFMSPTYTKDVARTLKKFLELKPEFGVYHMVNEGYCSWYEFTRAIFEILGWEVGVKPIKSSELKRLAKRPQLSALRNEKLEKLGLKMRHWREALGEYLKEKGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLW8</accession>
    <name>F0LLW8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT85067">
        <property type="protein sequence ID" value="ADT85067"/>
        <property type="gene ID" value="TERMP_02093"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02093"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2090"/>
    <dbReference type="HOGENOM" id="CLU_2930390_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="60" mass="7092" checksum="AAB2709AC1E170F5" modified="2011-05-03" version="1">MLTYYLGIWLYILFVKTKISPEKRNWGKIELYLKGLSYGKLGMLGISSMTVWKIVQKFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLZ0</accession>
    <name>F0LLZ0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02115"/>
    <dbReference type="EnsemblBacteria" id="ADT85089">
        <property type="protein sequence ID" value="ADT85089"/>
        <property type="gene ID" value="TERMP_02115"/>
    </dbReference>
    <dbReference type="GeneID" id="10042430"/>
    <dbReference type="KEGG" id="tba:TERMP_02115"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2112"/>
    <dbReference type="eggNOG" id="arCOG02487">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028321_0_0_2"/>
    <dbReference type="OMA" id="SDDTYVY"/>
    <dbReference type="OrthoDB" id="77279at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="646" mass="75100" checksum="B0318292579AB3D7" modified="2011-05-03" version="1">MKRVLVFVIVLLIASSGLGLALDRHIPYEIASENDKGIYIYLKSILLYSDIVLKNIIDENNDSVNYALKLETRLNMTREEVEFYKTMGIESKIEKYLPPFLKLGKGIKEIAEGQKIFLDNIEKVKTEKDYYSYMNATKGLNLIKEGISLSEEALDEIDVLEFLDENNVTVKLDTTQLRERLEEIKRMYLVYEKILRAYQVLSPEELQKLIKKEEKKTGKPVNTEEFIEKNRIIPIPERLTLHASKLNPFVYENVTFYGYAPGFNEVEIHIGNESFAVPVRNNYFSLKHVFKQVGSYRVFATGMRENKLETSNILLINVSKIPTNLIISSEKSAYVDQKLRIEGILLDYYRNPLGAQEIRASFDGEKLTLKTLKNGSFSFEISRKKEGKYLVNVTYLGNEIYAGSSASLSVYFMRHPVDIKIKTDKAKVKIGQELYIFGEVKGAKRPILISVYVDGKLYQQWLTKTVFGFKLRFNSTGTHEIYAYFSGDEYYAPAKSNLLKISVIKYSFREILIIALAFVSLLVLYVFVSSKKGQRKGISDEEFVELIKSLEELEVKEEGKKVKRLRDIYREVYYKLISYYNLKPTLTPRELLRKLRNESFSYDLERLTQLHERYFYGRKRLKRNEVIEYIKSAGRVIVSFIVREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLZ7</accession>
    <name>F0LLZ7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468392.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02122"/>
    <dbReference type="EnsemblBacteria" id="ADT85096">
        <property type="protein sequence ID" value="ADT85096"/>
        <property type="gene ID" value="TERMP_02122"/>
    </dbReference>
    <dbReference type="GeneID" id="10042437"/>
    <dbReference type="KEGG" id="tba:TERMP_02122"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2119"/>
    <dbReference type="eggNOG" id="arCOG01403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_2_2"/>
    <dbReference type="OMA" id="HEVWGDY"/>
    <dbReference type="OrthoDB" id="75045at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="188"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="374" mass="43329" checksum="8EB2B0A7BE2AE29F" modified="2011-05-03" version="1">MKITFIYDALYPEVKGGVEKRIYELGKRLAKKHEVHWYTFKWWGDKEIIERDGIIVHGIALPKNLYSGDRRSIREAIDFSFHLLLNRLEKSDIIDCQEFPYIPCYSTKFHSLLSKSELIITWHEYWGEYWREYIGHSAPFGKFLENNLLKITNNHIVVSKLTLANLSKLDSKNFSLIPNGIDLKRIQKVRSHDVKHDAIFVGRLIKHKNIGFLLRSIKFIRSDYPDFTLGIIGDGPERKKLEKLVKELGIYNNVEFLGFLDSHEAVIEHIKSSKVLTFPSLREGFGIVVLEANASGIPVVTVNAPMNASKELIIPGKNGYISELNEKSFAEKILLAYENSRKMKRTCINIARKYDWDVIAKRLEKYYEGVLSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM30</accession>
    <name>F0LM30_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00901</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467175.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00901"/>
    <dbReference type="EnsemblBacteria" id="ADT83877">
        <property type="protein sequence ID" value="ADT83877"/>
        <property type="gene ID" value="TERMP_00901"/>
    </dbReference>
    <dbReference type="GeneID" id="10041218"/>
    <dbReference type="KEGG" id="tba:TERMP_00901"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.902"/>
    <dbReference type="eggNOG" id="arCOG02245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036918_2_2_2"/>
    <dbReference type="OMA" id="AYGKRTF"/>
    <dbReference type="OrthoDB" id="118524at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="PTHR13353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="237" mass="25301" checksum="108A3477766DFD71" modified="2011-05-03" version="1">MTGISVIQFIMLVVFGFAAYVFKALDKMGSVSAVFLGMLILYFGGMYPFLALVVFVVMGVLSTRYRYSDKLKIGIAEGKKGIRSWRNVLGNGLAAGIFVMFEHAFQQDFLWAATFASIATANADTLASELGKILGKKPRIITNLKPATPGSNGAVSFQGELFAFIGALVIAFIAAEITQYKWQMLLATLLGGFIGCNIDSIVGATLENRGIVDNNGTNFIATVVGGIIGGIIFLSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM38</accession>
    <name>F0LM38_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467183.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00909"/>
    <dbReference type="EnsemblBacteria" id="ADT83885">
        <property type="protein sequence ID" value="ADT83885"/>
        <property type="gene ID" value="TERMP_00909"/>
    </dbReference>
    <dbReference type="GeneID" id="10041226"/>
    <dbReference type="GeneID" id="26136354"/>
    <dbReference type="KEGG" id="tba:TERMP_00909"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.910"/>
    <dbReference type="eggNOG" id="arCOG03415">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1056107_0_0_2"/>
    <dbReference type="OMA" id="WIVVKRL"/>
    <dbReference type="OrthoDB" id="48373at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022620">
        <property type="entry name" value="DUF2666"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10869">
        <property type="entry name" value="DUF2666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="264" mass="30293" checksum="50D9807B9E8FE4B6" modified="2011-05-03" version="1">MKIEEHVMFTAKHKNWKVGDKLLVMRDENIAHFLASISNTVNMKISEYLIDVIDVAAVMSLAEDLAEGELWEVVKVLKSPKTSRKIGKMVFESDKKLKKQLVDVAKALLVRETLSRMLSVYYPEDPIMELKIMLPYKEDHINFTAKHGSWIVVKRLIIDEKTELADVARLLASINETITSKLPIYAEIDLKGIDEWFAGVKKAKSDVEIKTLVDKYLHFPAHRYAPSEFEKHARIYALRKMLEKVGLSLDVPAKPLEKYLEKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM59</accession>
    <name>F0LM59_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable GTP 3',8-cyclase</fullName>
            <ecNumber evidence="11">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">moaA</name>
        <name evidence="13" type="ordered locus">TERMP_00930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="11"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467204.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00930"/>
    <dbReference type="EnsemblBacteria" id="ADT83906">
        <property type="protein sequence ID" value="ADT83906"/>
        <property type="gene ID" value="TERMP_00930"/>
    </dbReference>
    <dbReference type="GeneID" id="10041247"/>
    <dbReference type="KEGG" id="tba:TERMP_00930"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.931"/>
    <dbReference type="eggNOG" id="arCOG00930">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_0_1_2"/>
    <dbReference type="OMA" id="IEFMPIG"/>
    <dbReference type="OrthoDB" id="18533at2157"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_A">
        <property type="entry name" value="MoaA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013485">
        <property type="entry name" value="MoaA_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02668">
        <property type="entry name" value="moaA_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 11" id="KW-0408">Iron</keyword>
    <keyword evidence="7 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="6"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="256"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT83906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="307" mass="35955" checksum="C4AD16A9749C5998" modified="2011-05-03" version="1">MVLVDRFGRPVTNLRISVTEECNLSCFYCHREGQMKGKRQMTPQEIERIVKVASNLGIKKVKLTGGEPTIRSDIVEIVKRIRPYVVDLSMTTNGTVMHRLAEELRAAGLDRVNISLDTLDREKYKKITGFDVLPWVLKGIEKSVKLFKLVKLNMVVMRDLNHEEIWDMINYAAKIGAVLQLIEIEVPREMTESWFFKRYFYPLKPLEDEFSKKAVEIRERRMHRRKKYFIPTENGIAEVEVVRSMHNTVFCANCTRIRLTSDGYLKTCLLRRDDLVDILTPIRNGATDEELIEIFKQAIMLRRPYWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMC1</accession>
    <name>F0LMC1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_02170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468440.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02170"/>
    <dbReference type="EnsemblBacteria" id="ADT85144">
        <property type="protein sequence ID" value="ADT85144"/>
        <property type="gene ID" value="TERMP_02170"/>
    </dbReference>
    <dbReference type="GeneID" id="10042485"/>
    <dbReference type="KEGG" id="tba:TERMP_02170"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2165"/>
    <dbReference type="eggNOG" id="arCOG00001">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_2_0_2"/>
    <dbReference type="OMA" id="VFYASHV"/>
    <dbReference type="OrthoDB" id="16594at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="4">
        <location>
            <begin position="364"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT85144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="442" mass="49684" checksum="0C154CF27A6CA48B" modified="2011-05-03" version="1">MRCPRCGREYSSFIPPRCLCGELLEITYDYSNVDPGKWKSREKGVWRYKELLPEVDEIVTLKEGGTPLVKAKIGEELNLNVYIKDETRNPTGSFRDRLVTVGVSYGLPYSDNGFIVASDGNAAASLAAYAARANREAFVVVPRRVDKGKLIQMIAFGAKIIRYGDSVDECVDYAKELAKLNGLYDITPENNIIGLEGQKTVAFELWEEINPTHVVIPTGSGSNLYSIYKGFKELLEIGAIEELPKLIAVQTDKCNPIASEILGIKQKREFTKALGLYVKDPVNRERAVKAVKESGGTAVVVREDELDLGEKLLAKEGVFVEYASAVVVPALIKLSNEGYFEKDDRIVLIVTGSGLKSYYIDEREKFSIGGTKLKILKLLKEKPMYGYEIWENLEKPMKYQAVYQHIKELESLGLIEEACKKGRKIYYKLTEKGQRLLENFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMF0</accession>
    <name>F0LMF0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vitamin B12 ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TERMP_02199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468469.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02199"/>
    <dbReference type="EnsemblBacteria" id="ADT85173">
        <property type="protein sequence ID" value="ADT85173"/>
        <property type="gene ID" value="TERMP_02199"/>
    </dbReference>
    <dbReference type="GeneID" id="10042514"/>
    <dbReference type="KEGG" id="tba:TERMP_02199"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2194"/>
    <dbReference type="eggNOG" id="arCOG01007">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_2_2"/>
    <dbReference type="OMA" id="MMSSWKL"/>
    <dbReference type="OrthoDB" id="36067at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADT85173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="348" mass="37558" checksum="7B6951A8B07C5824" modified="2011-05-03" version="1">MKRLLFLFLLVSPIFAFFISLCIGAYHIPLSAIVDMVVLKTLQLISGILAKITFGRIDFAVQIPYPSVYQTILFKIRLPRVILAMIVGSALALSGAVLQAIFRNPLVNSYILGISAGAAFGAALAIGLSLSLGVTPLAFVFAILAVFLTTSLAKIGGRITPVSLVLAGVIVNAFFSALTSLLKFLMEHEKLASVVYWLMGSFADADWHSVKIAFPVIFLGCLLVYLMRWQLNVLSFGEEAKIVGVETEKLKFAFIIIISLITAVSVAFCGIIGWVGLMIPHIVRMAFGPDHKTLIPLTITVGASFMVLADTLARSVATYEIPIGILTTILGIPFFAYLLRKTGGGWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMH5</accession>
    <name>F0LMH5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467252.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00978"/>
    <dbReference type="EnsemblBacteria" id="ADT83954">
        <property type="protein sequence ID" value="ADT83954"/>
        <property type="gene ID" value="TERMP_00978"/>
    </dbReference>
    <dbReference type="GeneID" id="10041295"/>
    <dbReference type="KEGG" id="tba:TERMP_00978"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.981"/>
    <dbReference type="eggNOG" id="arCOG01299">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030705_2_0_2"/>
    <dbReference type="OrthoDB" id="15562at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042204">
        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="109"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="256"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="404" mass="45381" checksum="4EC1C0FB15D8A31B" modified="2011-05-03" version="1">MRPLDLYEKDSSKKVTIYFEGKSLEAYEGEPIHVALLANGIKWITLSGHGRKRGAFTFGPVLVTVNGVRNYDGRKTKVWDGMKIEMQSYMEPLPEHLGEMGKVERYYTDVVIVGSGAAGLGAALEMQDSLDVMIFEEKGRLGWGLLKRSVPLSNSKKPKEFRKELVERLRVKAFTRTPVLGVFRDGDYFIVVANKEKDLIEVTAKRVVVSTGGIAKFALFENNEMPGVFREDFVLELLNIWGVKPGNKITLYGSNSQNIAREFENHGLNYILIENPIVRAEGKNEVERVVDAKGNVYETDALIIAEGYRPDIHLAQQVGAEITYVEDLGGYLPLRNKRNEIVDGVYIAGNASWIKGSYENYLEGRLVGAYILEEFGFKSNVDQIKEEFLKKIGNKASLLEEVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LML2</accession>
    <name>F0LML2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467289.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01015"/>
    <dbReference type="EnsemblBacteria" id="ADT83991">
        <property type="protein sequence ID" value="ADT83991"/>
        <property type="gene ID" value="TERMP_01015"/>
    </dbReference>
    <dbReference type="GeneID" id="10041332"/>
    <dbReference type="KEGG" id="tba:TERMP_01015"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1018"/>
    <dbReference type="eggNOG" id="arCOG11082">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_197259_0_0_2"/>
    <dbReference type="OMA" id="MPRWISG"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="72" mass="8578" checksum="5AAB7C4A221F1A64" modified="2011-05-03" version="1">MPRWISGGYERGRRRSFWGFRRFSGFFGIVDLLFIVAILYVLIKLFLVAAPYVIALVVLLLLRDLLRPRMWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMM6</accession>
    <name>F0LMM6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467303.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01029"/>
    <dbReference type="EnsemblBacteria" id="ADT84005">
        <property type="protein sequence ID" value="ADT84005"/>
        <property type="gene ID" value="TERMP_01029"/>
    </dbReference>
    <dbReference type="GeneID" id="10041346"/>
    <dbReference type="KEGG" id="tba:TERMP_01029"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1032"/>
    <dbReference type="eggNOG" id="arCOG05804">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2313945_0_0_2"/>
    <dbReference type="OMA" id="EPYWDFL"/>
    <dbReference type="OrthoDB" id="122338at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="95" mass="11592" checksum="715D1A0928ED210F" modified="2011-05-03" version="1">MREEIKKFRVVRGYEKIKIAWKVIRGTAKYSNKEPFWEFLRKEFGIKDREIKEIMLFLEEVGELEIKRSQDGKRLYVSTLKDIKENPVKLDQWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMN8</accession>
    <name>F0LMN8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophanate hydrolase 2 subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467315.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01041"/>
    <dbReference type="EnsemblBacteria" id="ADT84017">
        <property type="protein sequence ID" value="ADT84017"/>
        <property type="gene ID" value="TERMP_01041"/>
    </dbReference>
    <dbReference type="GeneID" id="10041358"/>
    <dbReference type="KEGG" id="tba:TERMP_01041"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1044"/>
    <dbReference type="eggNOG" id="arCOG05809">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020207_1_0_2"/>
    <dbReference type="OMA" id="MPWMLAA"/>
    <dbReference type="OrthoDB" id="62224at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00370">
        <property type="entry name" value="TIGR00370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="225" mass="25114" checksum="63C618A019F221B3" modified="2011-05-03" version="1">MQFKPAGDSALVIIFGDRIDEGINKKVHAVASAIEKSSPDWLIEVVPTYTSIYVYYDPLKLSYQEALDAIKPFLSVEPKEEKPRIVEIPTAYGGEFGPDIEFVAQYNGLTIDDVIEIHSKPLYRVYMLGFTPGFAYLGGMDERIATPRLKKPRLKVPAGSVGIAGKQTGIYPIESPGGWRLIGRTPLRLFTPEKDPPTLLQPGDYVKFVPISEEEFWELHGGEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMS4</accession>
    <name>F0LMS4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467351.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01077"/>
    <dbReference type="EnsemblBacteria" id="ADT84053">
        <property type="protein sequence ID" value="ADT84053"/>
        <property type="gene ID" value="TERMP_01077"/>
    </dbReference>
    <dbReference type="GeneID" id="10041394"/>
    <dbReference type="KEGG" id="tba:TERMP_01077"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1080"/>
    <dbReference type="HOGENOM" id="CLU_1954774_0_0_2"/>
    <dbReference type="OrthoDB" id="135494at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="128" mass="14680" checksum="4DDE279EA7B1C9B1" modified="2011-05-03" version="1">MRKVDVRKLFVFSFFLMLTIGYSDIIVHKPSTFLELSFELIRGILLASAFFLAPLAILYYAQKKKLKVTIAVLFAVSIEFIWSILTKILGYGQYSRDFLIAGIVGILVIPFVYMEEKRGIIKNNTTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMS8</accession>
    <name>F0LMS8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467355.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01081"/>
    <dbReference type="ESTHER" id="thebm-f0lms8">
        <property type="family name" value="Monoglyceridelipase_lysophospholip"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84057">
        <property type="protein sequence ID" value="ADT84057"/>
        <property type="gene ID" value="TERMP_01081"/>
    </dbReference>
    <dbReference type="GeneID" id="10041398"/>
    <dbReference type="KEGG" id="tba:TERMP_01081"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1084"/>
    <dbReference type="eggNOG" id="arCOG01650">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026209_7_2_2"/>
    <dbReference type="OMA" id="FHGFSDH"/>
    <dbReference type="OrthoDB" id="69240at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="10"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="256" mass="28828" checksum="E9EE6766407616C8" modified="2011-05-03" version="1">MIYKAKFGTPERGWIVLVHGLGEHSGRYEKLINMLVDEGFAVYTFDWPGHGKSEGKRGHATVEQAMKIIDEIIEEIGEKPFLFGHSLGGLTVIRYAQTRPDRIKGIIASSPALEKSPKTPSFMVLLAKVLGSIVPTLTLSNGIDPNLLSRNKEAVRKYVEDKLVHDKISAALGKSIFENMEKAHEDAEKVKVPILILIGTEDVITPPEGARKLFENLTVEDKMLKEFKGAYHEIFEDPEWGDEFYMTIIEWLRIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMW5</accession>
    <name>F0LMW5_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L7Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ribosomal protein L8e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpl7ae</name>
        <name evidence="10" type="ordered locus">TERMP_01118</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit. Probably part of the RNase P complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01118"/>
    <dbReference type="EnsemblBacteria" id="ADT84094">
        <property type="protein sequence ID" value="ADT84094"/>
        <property type="gene ID" value="TERMP_01118"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01118"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1121"/>
    <dbReference type="eggNOG" id="arCOG01751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_4_0_2"/>
    <dbReference type="OMA" id="KPFYVRF"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00326">
        <property type="entry name" value="Ribosomal_L7Ae_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_L7Ae/L8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022481">
        <property type="entry name" value="Ribosomal_L7Ae_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_L7Ae_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000948">
        <property type="entry name" value="Ribosomal_L7Ae_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00884">
        <property type="entry name" value="RIBOSOMALHS6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03677">
        <property type="entry name" value="eL8_ribo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="9">
        <location>
            <begin position="29"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ADT84094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="133" mass="14602" checksum="C15BDC1895BEEA37" modified="2011-05-03" version="1">MNDEVLEGCEMAKPSYVKFEVPKELAEKALEAVEIARDTGRIRKGTNETTKAVERGQAKLVIIAEDVDPEEIVAHLPPLCEEKEIPYIYVPSKKELGAAAGIEVSAASVAIIEPGKARELVEEIAMKVRELMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMX2</accession>
    <name>F0LMX2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TrmA-like RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467399.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01125"/>
    <dbReference type="EnsemblBacteria" id="ADT84101">
        <property type="protein sequence ID" value="ADT84101"/>
        <property type="gene ID" value="TERMP_01125"/>
    </dbReference>
    <dbReference type="GeneID" id="10041442"/>
    <dbReference type="KEGG" id="tba:TERMP_01125"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1128"/>
    <dbReference type="eggNOG" id="arCOG00122">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_8_2_2"/>
    <dbReference type="OMA" id="YCGVGGF"/>
    <dbReference type="OrthoDB" id="33103at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
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        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="420" mass="47956" checksum="A0E574EE2FC0EFD0" modified="2011-05-03" version="1">MKAQGYIEEMSDEGLGVLKAEKPIYVPYTVAGDFVRVYTTRRRFGRYIAEKFEVVEFSQLRQSPRCMHFGKCGGCLWQHIRYKEQLKLKQENFRKITGIATDIKGSPKLFGFRNSSNFIVTTQGIGFKEYARPLSIVDVKECPVFSNKTWDYLKTLKEFMKEENLKAWDLKRKRGDVHYLSVREGKSTDEVMISLIAHIKPNEKLAEAFRDYFYFADSLYWSFKADKRDDPKGEPKLIAGKPYISERIGDVVYLIHPNSFFQANSYALPLLLKAAEGFTEGEKILDLYSGLGTFGIWLAKRGFKVEGVEANPFAVEMANKNAKLNGVDAVFRLGKAEETAIGDYDTAVVDPPRKGLKETAELLAKSNVENIIYVSCNPKAFKLDYENHLKKAYQIEDALLIDMFPHTPHVEAVVKLVRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN41</accession>
    <name>F0LN41_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467468.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84170">
        <property type="protein sequence ID" value="ADT84170"/>
        <property type="gene ID" value="TERMP_01194"/>
    </dbReference>
    <dbReference type="GeneID" id="10041511"/>
    <dbReference type="KEGG" id="tba:TERMP_01194"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1197"/>
    <dbReference type="eggNOG" id="arCOG03403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121823_6_0_2"/>
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    <dbReference type="OrthoDB" id="121913at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="124" mass="14312" checksum="B7AE2699E503BF01" modified="2011-05-03" version="1">MSPDPPKVIQQWEVVTMDFPFTDKTQKKTRPVLVISNTDFNRISNSLVVVQISTNLNSGLREYNVELTEEDINLYPRGYLKKKSIIKPYIVFSVAKGIVRARVGLLSSEKVEDVKRVIRKLYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN77</accession>
    <name>F0LN77_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
            <plasmid evidence="1 2">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747438.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02243"/>
    <dbReference type="EnsemblBacteria" id="ADT85216">
        <property type="protein sequence ID" value="ADT85216"/>
        <property type="gene ID" value="TERMP_02243"/>
    </dbReference>
    <dbReference type="GeneID" id="10549067"/>
    <dbReference type="KEGG" id="tba:TERMP_02243"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2237"/>
    <dbReference type="HOGENOM" id="CLU_2010206_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="123" mass="14685" checksum="11326A6A33542EBB" modified="2011-05-03" version="1">MEVIVAQDRLLGVEGFVTYSVVIEGKRVDGTVWYCYVDDSESNKFEWLKDDTFDGDIRRFGLEVIEKRMVEKDDGFECHVFFRIDKKFECVMSKEKFEEWLKKLFLEDGWVDVLIFDKKEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN84</accession>
    <name>F0LN84_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
            <plasmid evidence="2 3">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013747445.1">
        <property type="nucleotide sequence ID" value="NC_015471.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02250"/>
    <dbReference type="EnsemblBacteria" id="ADT85223">
        <property type="protein sequence ID" value="ADT85223"/>
        <property type="gene ID" value="TERMP_02250"/>
    </dbReference>
    <dbReference type="GeneID" id="10549074"/>
    <dbReference type="KEGG" id="tba:TERMP_02250"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2244"/>
    <dbReference type="eggNOG" id="arCOG03169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056180_0_0_2"/>
    <dbReference type="OrthoDB" id="141788at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="15"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="285" mass="33127" checksum="707938AC650109DA" modified="2011-05-03" version="1">MREELKQEILKELNKGNHILLRGQHGVGKTYLVNELLQENDRASQIWLYFPQPKPPKAILLEILKMVLEDGEANEKWKSYKRGSIPQLAQYIANELNRREFSMVIILDDFHTITTTSATAFRLLIEGTKKVKLLCVANDEYVDKLYKKPEMKRLVWELKTIEMEPFTEEEAKKFIEEESSRLGLSLSKQMKERILKNCNRNALCIKSQLEALKKGEELRENEHGAIQDKPINLFPILVILAFSLVAFKYISRGTGDKELYSFGSFISMMLYFAFKSLVVYPVRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN88</accession>
    <name>F0LN88_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase D/Transphosphatidylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>pTBMP1</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
            <plasmid evidence="3 4">pTBMP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002373">
        <property type="protein sequence ID" value="ADT85227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02254"/>
    <dbReference type="EnsemblBacteria" id="ADT85227">
        <property type="protein sequence ID" value="ADT85227"/>
        <property type="gene ID" value="TERMP_02254"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02254"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2248"/>
    <dbReference type="eggNOG" id="arCOG02039">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG05613">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1017885_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Plasmid pTBMP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="304" mass="35253" checksum="58E3F89F1C9DDCD5" modified="2011-05-03" version="1">MLKKSLVIVIPLLLLLLSSGCIDTKTISFTSSVSTPTVSPRETQQTITQTHNDNYSKELQYWKSKYLELERKYNLTKEAYDNLTKLNKELELKIRNLTVQLQIMNQSLQKSVNMTVKFFKEKTYYEKLYKSCSANLTKLNRSYLSCKSQLSQLQNQESTKTYLLIDQEYYHKALILINQANESIYLIMYVAKYDAGDSFDWANDLINALIKAKQRGVDVHVILDNYPNVNEATKEYLAKYGIDVRFDSPSKTTHAKILIIDGKVVLIGSHNWTESALYYNHEVSVLVYSEDFAKELISYFYSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH68</accession>
    <name>F0LH68_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83030">
        <property type="protein sequence ID" value="ADT83030"/>
        <property type="gene ID" value="TERMP_00052"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00052"/>
    <dbReference type="HOGENOM" id="CLU_3210927_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="44" mass="5279" checksum="D92DDA76CE5F8B5C" modified="2011-05-03" version="1">MIIKIPFLFIPTTSLCSKFRMRFLKDFWEKLFNLSALPLMEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH69</accession>
    <name>F0LH69_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="7">BPG-independent PGAM</shortName>
            <shortName evidence="7">Phosphoglyceromutase</shortName>
            <shortName evidence="7">aPGAM</shortName>
            <ecNumber evidence="7">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">apgM</name>
        <name evidence="9" type="ordered locus">TERMP_00053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="7"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466329.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00053"/>
    <dbReference type="EnsemblBacteria" id="ADT83031">
        <property type="protein sequence ID" value="ADT83031"/>
        <property type="gene ID" value="TERMP_00053"/>
    </dbReference>
    <dbReference type="GeneID" id="10040372"/>
    <dbReference type="KEGG" id="tba:TERMP_00053"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.53"/>
    <dbReference type="eggNOG" id="arCOG01696">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034906_2_0_2"/>
    <dbReference type="OMA" id="IAFRCNF"/>
    <dbReference type="OrthoDB" id="17268at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16011">
        <property type="entry name" value="iPGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01402_A">
        <property type="entry name" value="ApgM_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023665">
        <property type="entry name" value="ApgAM_prokaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042253">
        <property type="entry name" value="Pglycerate_mutase_ApgM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="PTHR31209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10143">
        <property type="entry name" value="PhosphMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006392">
        <property type="entry name" value="IPGAM_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00306">
        <property type="entry name" value="apgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="8">
        <location>
            <begin position="4"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ADT83031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="410" mass="44915" checksum="3D4F1FF82FECFD59" modified="2011-05-03" version="1">MKRKGILIIIDGLGDRPIKEFGGKTPLEYANTPNLDKLAKIGILGLQDPIKPGQPAGSDTAHLSIFGYNPYKTYRGRGFFEALGVGLDLDKDDLAFRVNFATIKNGIIVDRRAGRISTEEAHELAKAIQENVKLPVEFIFKGATGHRAVLVLKGMAKGYKVGENDPHEAGKPPHKFTYGDEESRKVAEILEEFVQKAHEVLENHPVNEKRRKEGKPVANYLLIRGAGTYPDIPMKFTEQWGVKAAAVLATALVKGVARAIGFDVFTPEGATGEYNTDEMAKAKAAVELLKDYDFVFVHFKPTDAAGHDNKPKLKAEMVEKADRMIGYIIENIDLEKTVIAVTGDHSTPCEVMNHSGDPVPLLIAGGGVRTDYAESFGERECMRGGIGRVKGHDIVPMMMDLMGRTEKFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LH85</accession>
    <name>F0LH85_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfhydrogenase II subunit d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466345.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00069"/>
    <dbReference type="EnsemblBacteria" id="ADT83047">
        <property type="protein sequence ID" value="ADT83047"/>
        <property type="gene ID" value="TERMP_00069"/>
    </dbReference>
    <dbReference type="GeneID" id="10040388"/>
    <dbReference type="KEGG" id="tba:TERMP_00069"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.69"/>
    <dbReference type="eggNOG" id="arCOG02472">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053270_0_0_2"/>
    <dbReference type="OMA" id="CKLNEYE"/>
    <dbReference type="OrthoDB" id="44934at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="245" mass="27429" checksum="8A9CA898E811652A" modified="2011-05-03" version="1">MLKLGVFELTDCGGCALNILFLYEKLFDLLEFYDIKEFHMASSFKEHDHLDVAIVTGTVSCQRDLEVLRHARNYSNYLIALGTCATHGSVQGAVEGKLRDKLEKVYGTRANTMKALDPKPVVEYVAVDFALPGCPYDKMEIYQLLLDLAKGVEPIKKDYPVCIECKLNEYECVLVKKGLPCLGPITVGGCNAICVKSKLGCIGCRGPLPKEANPAGEFEILKNLGYDEEYLRRKFKTFARGELRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LHN2</accession>
    <name>F0LHN2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEMO1 family protein TERMP_00139</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466414.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00139"/>
    <dbReference type="EnsemblBacteria" id="ADT83116">
        <property type="protein sequence ID" value="ADT83116"/>
        <property type="gene ID" value="TERMP_00139"/>
    </dbReference>
    <dbReference type="GeneID" id="10040457"/>
    <dbReference type="KEGG" id="tba:TERMP_00139"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.140"/>
    <dbReference type="eggNOG" id="arCOG01728">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038085_2_0_2"/>
    <dbReference type="OMA" id="EQEAQYG"/>
    <dbReference type="OrthoDB" id="82745at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PTHR11060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="292" mass="32327" checksum="D0D110E4B2D6B26A" modified="2011-05-03" version="1">MIRYPAVAGSFYPTGEELVIMLERFFSDLGELGSERKITAGVAPHAGYVFSGYTASRTYKAIYEDGLPETFVIIGPNHTGLGSPVAVYPEGEWITPLGGVEVDAELAKAIVKNSSIADLDELAHKYEHSIEVQLPFIQYIADKAGRKIKIVPITLGLQDEEVAEDLGKAIFEASQELGRDVVVIASTDMMHYGYMYGYIPFRARGEDLLGRIKEWDFRVIQRILEFDYKGMFDEIRKMDHTMCGPGGVAAGIVFSRLADANEAELLHYTTSFEVSRSTDAIVGYASVVMRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI21</accession>
    <name>F0LI21_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dCTP deaminase</fullName>
            <ecNumber evidence="2">3.5.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Deoxycytidine triphosphate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dcd</name>
        <name evidence="5" type="ordered locus">TERMP_00198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the deamination of dCTP to dUTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dCTP + H(+) + H2O = dUTP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="EC" id="3.5.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466473.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00198"/>
    <dbReference type="EnsemblBacteria" id="ADT83175">
        <property type="protein sequence ID" value="ADT83175"/>
        <property type="gene ID" value="TERMP_00198"/>
    </dbReference>
    <dbReference type="GeneID" id="10040516"/>
    <dbReference type="KEGG" id="tba:TERMP_00198"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.199"/>
    <dbReference type="eggNOG" id="arCOG04048">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087476_3_1_2"/>
    <dbReference type="OMA" id="RTSWIRK"/>
    <dbReference type="OrthoDB" id="91282at2157"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="79"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="157" mass="17765" checksum="C23FC1B6DCBE1644" modified="2011-05-03" version="1">MILPDHKIVKEILIEPFSEKSLQPAGYDLRVGSEAMVNGKFINVKEDGKVVIPPKGYALILTLERIKLPDDVMGEMRLRSSLAREGLIGSFAWVDPGWDGNLTLGIFNGSNEEIELEYGERFVQIIFHRLEEPTSKPYRGNYQGSQHLALSKRRNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI41</accession>
    <name>F0LI41_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466493.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00218"/>
    <dbReference type="ESTHER" id="9eury-b5ivx6">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.B04"/>
    <dbReference type="EnsemblBacteria" id="ADT83195">
        <property type="protein sequence ID" value="ADT83195"/>
        <property type="gene ID" value="TERMP_00218"/>
    </dbReference>
    <dbReference type="GeneID" id="10040536"/>
    <dbReference type="KEGG" id="tba:TERMP_00218"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.218"/>
    <dbReference type="eggNOG" id="arCOG01651">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_6_2_2"/>
    <dbReference type="OMA" id="EDCGYTN"/>
    <dbReference type="OrthoDB" id="69240at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="66"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="287" mass="33064" checksum="47A2A9392CD19F1E" modified="2011-05-03" version="1">MIIKILILFLILFFLFVVFVAYKMVKPPREIKGWTPKDLGYDYEEVTIQTKDGLNLHGWWIDQGNEKTVIPLHGYTSSKWNDLYIKPTMEILLNAGYNVLAFDFRAHGKSEGKYTTVGDKELIDLISAIDWLKENHPEKAKKIGLIGFSMGAMVTIRALAEDERVCCGVADSPPMHLDKTGARGLKYFAKLPEWLYIFVKPFTLIISGGKVVHPLEYADKVKKPLLLIAGKKDPLVKVEEIQEFYERNKKINPNVELWVTEAPHVRTILIAKDEYKKRILEFFERHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F0LI75</accession>
    <name>F0LI75_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable 6-oxopurine nucleoside phosphorylase</fullName>
            <ecNumber evidence="1">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Purine nucleoside phosphorylase</fullName>
            <shortName evidence="1">PNP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466527.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00252"/>
    <dbReference type="EnsemblBacteria" id="ADT83229">
        <property type="protein sequence ID" value="ADT83229"/>
        <property type="gene ID" value="TERMP_00252"/>
    </dbReference>
    <dbReference type="GeneID" id="26135595"/>
    <dbReference type="KEGG" id="tba:TERMP_00252"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.252"/>
    <dbReference type="eggNOG" id="arCOG01327">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_0_2_2"/>
    <dbReference type="OMA" id="MTQCPEA"/>
    <dbReference type="OrthoDB" id="63298at2157"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="3"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="50"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="212"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="267" mass="30015" checksum="E0833EF5E2CFC106" modified="2011-05-03" version="1">MVRIAIIGGSGVYDPKLLENIREEEINTPYGKIKVKIGTYKGEEIAFLARHGEKHSVPPHKINYRANIWGLYELGVERILATSAVGSLNKAMKPGDFVILDQLMDFTKNRVYTFYDGEDSPHDRKFVAHIDFTDPYCPEIRNALIRAAKELGFSYHPKGTYACMEGPRFETRAEIRALRILGADVVGMTQCPEAILARELEMCYSSVAIVTNFAAGISSQKLTHTEVVELMAKKSEEIKYLLMKAIEYIPKERRCMCKDALKGATGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIA8</accession>
    <name>F0LIA8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NhaD-like Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TERMP_01463</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467736.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01463"/>
    <dbReference type="EnsemblBacteria" id="ADT84438">
        <property type="protein sequence ID" value="ADT84438"/>
        <property type="gene ID" value="TERMP_01463"/>
    </dbReference>
    <dbReference type="GeneID" id="10041779"/>
    <dbReference type="KEGG" id="tba:TERMP_01463"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1463"/>
    <dbReference type="eggNOG" id="arCOG00238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011920_4_0_2"/>
    <dbReference type="OMA" id="IAMFIDV"/>
    <dbReference type="OrthoDB" id="49249at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="15"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADT84438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="425" mass="46217" checksum="CC340C427DDB7CB4" modified="2011-05-03" version="1">MNPETVAIAVFLLTYALVVSERIHRAVAAMLGASAVLFLKIVPWERVPKYLDLNTLFLLMGMMIIVNTARNSGLFEYVAIKTVKLARGSPIRVLLLFSVVTAIVSSVLDNVTTVLLLTPMLLYISRLMELNPVPFLLSEIFASNIGGTATLIGDPPNIMIGSAAKLSFNEFLSNMGPIAAVDLIVTVLIIYLAYNSALKVTPKKKVMIKQTLRGLDERAAIRDIRLFRKSVAIILFVVALFFFHDKLGIEPAVVALLGASLILLWTREDPEGIFEKIEWPALFFFGGLFIIVGALEETGTIAQVAEWVLNHVHTSGEALLAITWFSAFSSAIVDNIPLTAAMIPLIKHMGTSMDVYPLWWALSLGACLGGNGTAIGASANVVVIGIAEREGIRITFGDFLKAGMVIMITTVAIGVGILWVRYIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIF0</accession>
    <name>F0LIF0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467778.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01505"/>
    <dbReference type="EnsemblBacteria" id="ADT84480">
        <property type="protein sequence ID" value="ADT84480"/>
        <property type="gene ID" value="TERMP_01505"/>
    </dbReference>
    <dbReference type="GeneID" id="26137016"/>
    <dbReference type="KEGG" id="tba:TERMP_01505"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1505"/>
    <dbReference type="HOGENOM" id="CLU_2930389_0_0_2"/>
    <dbReference type="OrthoDB" id="132065at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="60" mass="6985" checksum="48B5FE589B59D8A7" modified="2011-05-03" version="1">MFRSKYRERAWWSMFVGLLFAFSGAYGKFKPMIIVGILFATFGVILLEYDRRVSHDSGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIF2</accession>
    <name>F0LIF2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467780.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01507"/>
    <dbReference type="EnsemblBacteria" id="ADT84482">
        <property type="protein sequence ID" value="ADT84482"/>
        <property type="gene ID" value="TERMP_01507"/>
    </dbReference>
    <dbReference type="GeneID" id="10041823"/>
    <dbReference type="KEGG" id="tba:TERMP_01507"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1507"/>
    <dbReference type="eggNOG" id="arCOG01462">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050524_0_0_2"/>
    <dbReference type="OMA" id="IMMLIIM"/>
    <dbReference type="OrthoDB" id="31143at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="429" mass="47244" checksum="6F445CF4F222A35F" modified="2011-05-03" version="1">MSDFFVMVIKELKDLMRNKQIIVGMIIVPLILFPALGKMISFGMSEAKEETKVILVNFDEGKYGNVLISALRAAPNVTVTLIDAQTVQEAIQKAQAEGYNVVVVIPKDFSKNIEANQKTYVEVYAVFKGISAGIKESVSEGRINAVLQVLNEELAKLKIKEAVKGNPEAILHPIDAKSYSVIQGRIVNVPPSIVSGIIYSQAFSIPLVLFIMISYVSQMAATTMAAEKENKTLETLLTLPVKRMTIITGKMVGTAIIALVASIAYMVGLKYYISSFTPENMTQIGITLKDLGLEMTPKGALLFGISLFLSIVFALSLAMLISVFAEDIRSASTMVSMIMMPLLFPIWILMFKDISTLPPAVKYFLYAIPFSHPVIASRAVLLKQYAIVYAGIAYLLFISGAMLYITAKFFSTEKVLTAKLKWGKRKRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIF9</accession>
    <name>F0LIF9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide transport ATP-binding DppD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TERMP_01514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467787.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01514"/>
    <dbReference type="EnsemblBacteria" id="ADT84489">
        <property type="protein sequence ID" value="ADT84489"/>
        <property type="gene ID" value="TERMP_01514"/>
    </dbReference>
    <dbReference type="GeneID" id="10041830"/>
    <dbReference type="KEGG" id="tba:TERMP_01514"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1514"/>
    <dbReference type="eggNOG" id="arCOG00181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="GSMPRID"/>
    <dbReference type="OrthoDB" id="43111at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT84489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="326" mass="36195" checksum="A139D75EF661D1CF" modified="2011-05-03" version="1">MPEPILQVRNLTVHFYTYAGIVKAIERVSFDVYRGETFALVGETGCGKSVTSRALTQLIESPGRIVEGEVLYHKEDGTVVDLLKLNEEQIREIRGNEIAYIFQDPHASLDPLYTVGYQIAEAMEVHGKVESIKEGIKKAVDILRSVLIPDPENRVKNYPHELSGGMKQRVVIGIGIANNPKILIADEPTTALDVTVQAQILDLINQLKEKYKATVILITHNLGVVAETADRVAVMYAGKIVEIGSVEQIFKNPLHPYTKGLLKAVPNPMTKIERLEAIPGTVPNLITPPSGCRFHPRCPFATEVCKRKVPELKEMEDGHFVACHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIG0</accession>
    <name>F0LIG0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dipeptide transport system permease DppC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467788.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01515"/>
    <dbReference type="EnsemblBacteria" id="ADT84490">
        <property type="protein sequence ID" value="ADT84490"/>
        <property type="gene ID" value="TERMP_01515"/>
    </dbReference>
    <dbReference type="GeneID" id="10041831"/>
    <dbReference type="KEGG" id="tba:TERMP_01515"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1515"/>
    <dbReference type="eggNOG" id="arCOG00748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_2_2"/>
    <dbReference type="OMA" id="YYRVVRN"/>
    <dbReference type="OrthoDB" id="63271at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="135"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="385" mass="43210" checksum="44C49297FABD75DB" modified="2011-05-03" version="1">MQEEYKKSILDKLADKIVYGLGSFISLFKKGWKEKNKSKMEEWRLMLYALNRSPPALIGLFLVILFILVGIFGPRLAHWRYNFFPMLYTKSYDKIVLAPPGSKFVLDYYNNTVITFPLGSDHYGRDLLSLILSGARTSFVISIIVISLGVPLGIILGLIAGYYGGKVDELIMRITDMFLAFPALILAIALSAVLPERIQNFISTHEAVQKFVLWLFALDVREAGNLGRLLAVILAMIIVWWPAYARITRGSTLTEKEKLYIEAARAIGLPARTIMFKHILPNIIGPILVYITLDFGGVILMEAGLSFLGLGATPPIADWGRIVYDGAQYFPKAWWLVFYPGLVVMLVALGWNLLGDGLRDILDPKTRRSIEFKVKKSKKEGEANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIG8</accession>
    <name>F0LIG8_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_00265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466540.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00265"/>
    <dbReference type="EnsemblBacteria" id="ADT83242">
        <property type="protein sequence ID" value="ADT83242"/>
        <property type="gene ID" value="TERMP_00265"/>
    </dbReference>
    <dbReference type="GeneID" id="26135606"/>
    <dbReference type="KEGG" id="tba:TERMP_00265"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.265"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OMA" id="HVSGDYD"/>
    <dbReference type="OrthoDB" id="97695at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT83242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="147" mass="16880" checksum="C13D88DF732AF50E" modified="2011-05-03" version="1">MIDELDRKILSLLQKDARLSYREIAKKLNVAVGTVYNRLKRLEEEGILKGFYPKLDYEKLGYELTAIIGVRAQGKRIIQIEKEIAKDDHVLCVYDVTGEYDIIVVAKFKGREDMNRFVKKVLAIDGVEKTNTHVAMDIVKEDLVLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIL0</accession>
    <name>F0LIL0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L35Ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl35ae</name>
        <name evidence="3" type="ordered locus">TERMP_00307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466582.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00307"/>
    <dbReference type="EnsemblBacteria" id="ADT83284">
        <property type="protein sequence ID" value="ADT83284"/>
        <property type="gene ID" value="TERMP_00307"/>
    </dbReference>
    <dbReference type="GeneID" id="26135648"/>
    <dbReference type="KEGG" id="tba:TERMP_00307"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.307"/>
    <dbReference type="eggNOG" id="arCOG04304">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100745_3_1_2"/>
    <dbReference type="OMA" id="SKENQHN"/>
    <dbReference type="OrthoDB" id="108945at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="L35A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_L35A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="PTHR10902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="85" mass="9468" checksum="2C18D89891E3D31A" modified="2011-05-03" version="1">MKGIVLSYMRSKENQHNHHMIIKPLGIESREEAAKLIGKKVIWKSPSGKIIAGKIVKPHGVRGEVKVRFEKGLPGQALGDYVQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIN0</accession>
    <name>F0LIN0_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">corA</name>
        <name evidence="7" type="ordered locus">TERMP_00327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466602.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00327"/>
    <dbReference type="EnsemblBacteria" id="ADT83304">
        <property type="protein sequence ID" value="ADT83304"/>
        <property type="gene ID" value="TERMP_00327"/>
    </dbReference>
    <dbReference type="GeneID" id="10040645"/>
    <dbReference type="KEGG" id="tba:TERMP_00327"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.327"/>
    <dbReference type="eggNOG" id="arCOG02265">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_0_0_2"/>
    <dbReference type="OMA" id="IQKYFRD"/>
    <dbReference type="OrthoDB" id="43588at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="322" mass="38250" checksum="25669673114A001D" modified="2011-05-03" version="1">MENPQITLFAYSKNKFTEKRLESLEEVFNYKDYPVVWVNIDGIAYLDELKNIFGFYDTSIRLILRSKSRPKVEIFGDYLFILIYQVYESSGGLKREKTAIFLKDNYVITLQEVKGDVFNSIRESIRKGEGLVREKKADYLIFLLLDAVINNYIPILDKINAKMEAIEDKILRNSDREMLRKIHTIRRRILFMRRAIFPLLEVFRELQLEGTRFFEEDTKPYLRELNAHVLEVLDLIESQREMANGLIDIYYSTISMRINEIMRVLTVISTIFIPLTFITGLYGMNFRYMPELGWRYGYPAVLLVMLMISLSMLYYFKRKGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIQ6</accession>
    <name>F0LIQ6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7-cyano-7-deazaguanine synthase</fullName>
            <ecNumber evidence="1">6.3.4.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Archaeosine biosynthesis protein QueC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queC</name>
        <name evidence="2" type="ordered locus">TERMP_01533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27982"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.20" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467806.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01533"/>
    <dbReference type="EnsemblBacteria" id="ADT84508">
        <property type="protein sequence ID" value="ADT84508"/>
        <property type="gene ID" value="TERMP_01533"/>
    </dbReference>
    <dbReference type="GeneID" id="10041849"/>
    <dbReference type="KEGG" id="tba:TERMP_01533"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1533"/>
    <dbReference type="eggNOG" id="arCOG00039">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081854_1_1_2"/>
    <dbReference type="OMA" id="CESCMRR"/>
    <dbReference type="OrthoDB" id="90765at2157"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01995">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01633">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00364">
        <property type="entry name" value="TIGR00364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="242" mass="26893" checksum="AD16325E345348A9" modified="2011-05-03" version="1">MRRAVVLFSGGLDSTACLYWAKKNYDEVIMLTINYGSNEERATNKVAEFFSKELNIPLKIIKLDFLEEFSKLRGTTLVGGETPRVTARDLENMERAQETAKSVWVPARNVVLISVAASLLDALGGGDIIVGFNAEEGATFPDNTPEFVEKMNEMLRYGALSEVKVVAPLINLDKKGIAKLLKELNAKYEYSNSCYMPKGFTEDGKPIHCGECESCVRRHRGLMEGVGEDKTVYAIRPKIEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIS1</accession>
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        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DrrA"/>
    </dbReference>
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        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ADT84523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="324" mass="37244" checksum="583C190AE52D37C3" modified="2011-05-03" version="1">MHAIEVSELRKKYPKKIPLPFRKVEWIEAVRGISFKVKKGELFGLLGPNGAGKTTTIKMLTTLLEPSGGTAKILGFDIRKDAREIRKRINLVAEGERTLYWRLSAYENLKYFARIYYVPKKEERERIGKLLKLVGLWERKDDLVMNYSRGMKQRLAIAKALINDPEVLFLDEPTLGLDVQSAVFVREFIRKLVDKQKKTVLLTTHYMAEAEELCDRIAIIDQGRIIALDTPEGLKKLVKGEDVVEIKVREFSVQKMEGFPWKLVVVKEDAERGITTLRGQIDEEDLPKVVELLVKRGVRILSVEQKEPTLEDVFIKLTGRALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIS2</accession>
    <name>F0LIS2_THEBM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|391623.17.peg.1549"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="107987at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="93" mass="11004" checksum="1194B4BFF21070EC" modified="2011-05-03" version="1">MEIIVEKFKPKITRPFKRKNEYWVKLIDESGEYIMKFKSPLEAEDAVYGLLDLQVYGGKVRLKLREGNVIEDIEILELYKPSAKELVDEYFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LIY6</accession>
    <name>F0LIY6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Superoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the desulfoferrodoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00355"/>
    <dbReference type="EnsemblBacteria" id="ADT83332">
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    </dbReference>
    <dbReference type="GeneID" id="26135699"/>
    <dbReference type="KEGG" id="tba:TERMP_00355"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.355"/>
    <dbReference type="eggNOG" id="arCOG02146">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118960_2_1_2"/>
    <dbReference type="OMA" id="HHIAWIE"/>
    <dbReference type="OrthoDB" id="106274at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00332">
        <property type="entry name" value="neela_ferrous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Desulfoferrodox" evidence="6">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="115" mass="13115" checksum="48B8D471981401CC" modified="2011-05-03" version="1">MLSKTIASGDWKGEKHVPVIEYKKDGDLLEIEVSVGKEIPHPNTPEHHIAWIELYFHPEGEKFPVMVGRVAFTNHGDPLTEPKAKFYIRTSKKGKLYALSYCNIHGLWENSVDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ13</accession>
    <name>F0LJ13_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polbeta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00382"/>
    <dbReference type="EnsemblBacteria" id="ADT83359">
        <property type="protein sequence ID" value="ADT83359"/>
        <property type="gene ID" value="TERMP_00382"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00382"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.382"/>
    <dbReference type="eggNOG" id="arCOG02107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154345_0_0_2"/>
    <dbReference type="OMA" id="SYAKNEY"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="137" mass="16267" checksum="48B0AB0A9F20D334" modified="2011-05-03" version="1">MDIITQLKKDFKEFKDFCLGIVLYGSYAKGSQTGRSDIDVCLIKPEKGIYERVLEKLGGKYDVKIFEELPLYIKIDIIKNHRIIYGDELEISEYFYHFRKLWKDMEHRIKENQFSSIREKVALRRRANEKAKILGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ19</accession>
    <name>F0LJ19_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-layer structural protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466663.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00388"/>
    <dbReference type="EnsemblBacteria" id="ADT83365">
        <property type="protein sequence ID" value="ADT83365"/>
        <property type="gene ID" value="TERMP_00388"/>
    </dbReference>
    <dbReference type="GeneID" id="10040706"/>
    <dbReference type="KEGG" id="tba:TERMP_00388"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.388"/>
    <dbReference type="eggNOG" id="arCOG03418">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_437217_0_0_2"/>
    <dbReference type="OMA" id="NHFESDD"/>
    <dbReference type="OrthoDB" id="37561at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022651">
        <property type="entry name" value="S_layer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006454">
        <property type="entry name" value="S_layer_MJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022650">
        <property type="entry name" value="S_layer_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05124">
        <property type="entry name" value="S_layer_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05123">
        <property type="entry name" value="S_layer_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01564">
        <property type="entry name" value="S_layer_MJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S_layer_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="S_layer_C" evidence="2">
        <location>
            <begin position="354"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="572" mass="62651" checksum="1541B887B974C33F" modified="2011-05-03" version="1">MKVRKIAALAVGAAMVGATMGFASAQANLPGKDFFVKDGQPNVKIVVGSQAAAMDVASAADIAVALGSLLYTEKEAEAAGVSVVVKKDLTPDYTYYIPVFSNYYEDTGTNPSATAWDQLTDNWWNGSAYNGSYTDWTSWTPKFVDEVENMDAINGDYQVDWDFTISNIELSDPEQNTIVYVPRSADLTIPAGDFTVLLNYTIANWTYSATEPDSIWGTLNPSTVYDEVHDDDNPGGYTFSGYIYDGVGAGDTFTVLGNTYYILDVLADGIKYGHDHGQVWFHVGDVKEFDGYKIKAVDISVSPSNKALFEITAPDGRSDLVIISTDEGDVDISTKSDKFNPGEVVLKLDDTFVGIDGNLIAQLEVRTNVVEVHTGDELVSGWVVNFTIENNKVKWLTLTNANDLSGSTLDILGKYKMYYEVDSHTLETDDTTYYAAKAYIVVKPSEPIIQTEELKVGDEVSDTGWVVDQIKGGTYTEVTVMHPTEPITYLDTEIDPENIDSNLILVGGPVANAVTKYLVDNGYSTVDWYNSAGDIEYIEDYNGFGILIVAGKDRYATREAAKQLMEYLANLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ23</accession>
    <name>F0LJ23_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466667.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00392"/>
    <dbReference type="EnsemblBacteria" id="ADT83369">
        <property type="protein sequence ID" value="ADT83369"/>
        <property type="gene ID" value="TERMP_00392"/>
    </dbReference>
    <dbReference type="GeneID" id="26135733"/>
    <dbReference type="KEGG" id="tba:TERMP_00392"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.392"/>
    <dbReference type="eggNOG" id="arCOG04130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076814_1_0_2"/>
    <dbReference type="OMA" id="IGKKLMW"/>
    <dbReference type="OrthoDB" id="112466at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007003">
        <property type="entry name" value="DUF655"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40734">
        <property type="entry name" value="PTHR40734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04919">
        <property type="entry name" value="DUF655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="207" mass="24988" checksum="4F70D1FBE18BFD93" modified="2011-05-03" version="1">MDYYRKHSYMQSIKKKRNTEYEEYAYVLDYLPTGYIDMEHFRMKRDNKPVAQVIGEKAFTLLEVVPKADLMLYERVFIGKGQRDKILMINRKLRYEDLTPTAKAELPYVVEEIVKNNEHRFIRFFNIAPPITNRLHSLELLPGIGKKHMWEIIEERQRQPFESFEDLRHRVKGLPDPVKMIAKRILDELQGKDRYRLFVGHNRLFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJ86</accession>
    <name>F0LJ86_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467906.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01633"/>
    <dbReference type="EnsemblBacteria" id="ADT84608">
        <property type="protein sequence ID" value="ADT84608"/>
        <property type="gene ID" value="TERMP_01633"/>
    </dbReference>
    <dbReference type="GeneID" id="26137169"/>
    <dbReference type="KEGG" id="tba:TERMP_01633"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1633"/>
    <dbReference type="eggNOG" id="arCOG05718">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2713052_0_0_2"/>
    <dbReference type="OMA" id="KWYVRRI"/>
    <dbReference type="OrthoDB" id="125842at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="72" mass="8810" checksum="C7526FE19ADB07B1" modified="2011-05-03" version="1">MFMAEFKLRYGSMKWYVRRIVEAETFEEAKELAERYVKAINRGEVKWELNDIYEVDKPLMITKEMVERLEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJD9</accession>
    <name>F0LJD9_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466703.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00428"/>
    <dbReference type="EnsemblBacteria" id="ADT83405">
        <property type="protein sequence ID" value="ADT83405"/>
        <property type="gene ID" value="TERMP_00428"/>
    </dbReference>
    <dbReference type="GeneID" id="10040746"/>
    <dbReference type="KEGG" id="tba:TERMP_00428"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.428"/>
    <dbReference type="eggNOG" id="arCOG04333">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_2"/>
    <dbReference type="OMA" id="NDECYSE"/>
    <dbReference type="OrthoDB" id="32104at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="18"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="345" mass="39377" checksum="47946313BEB5B08D" modified="2011-05-03" version="1">MFNVYEFFNKISSINPEIRLDAGQPDIKVDERIIEEAVNSLKRYETGYTKTPGLDELREKIAEVEGVEKENVIVGNGSKILIASQILRAKRIGIISPHWQAYESPAKMFGKELRIFKTSLEEGWEPKIERLNVDLLILNYPNNPTGKILPREKLKEILEIAEDENVKVLADEIYSDITFKPFTPARELYDNVVTVKGFSKLFSMTGFRVGYAIAQREDIKAMQKFLEVTTTCVPIFIQRAGVKALEIRDEIKKRVVRIYEERARLASRILKGTFEFYKPDGTFYLFVKTGVDGLSFAEKLLEKGVSVFPGIAFGDYRDFIRISLVSSRLEEGLKIIKEVKLCALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJP1</accession>
    <name>F0LJP1_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0273 protein TERMP_01708</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0273 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467981.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01708"/>
    <dbReference type="EnsemblBacteria" id="ADT84683">
        <property type="protein sequence ID" value="ADT84683"/>
        <property type="gene ID" value="TERMP_01708"/>
    </dbReference>
    <dbReference type="GeneID" id="26137091"/>
    <dbReference type="KEGG" id="tba:TERMP_01708"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1707"/>
    <dbReference type="eggNOG" id="arCOG01171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_2_0_2"/>
    <dbReference type="OMA" id="FSQQFLW"/>
    <dbReference type="OrthoDB" id="76011at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01076">
        <property type="entry name" value="UPF0273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022475">
        <property type="entry name" value="UPF0273_KaiC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03877">
        <property type="entry name" value="thermo_KaiC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="3"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="247" mass="27600" checksum="F00A3E75403E8D1E" modified="2011-05-03" version="1">MVKRVKTGIPGMDEILHGGIPERNVVLLSGGPGTGKTIFSQQFLWNGLQMGEPGIYVALEEHPVQVRQNMAQFGWDVKKYEEEGLFAMVDAFTAGIGRSKEYEKYIVHDLTDLREFIDVLRQAIRDIGAKRVVVDSVTTLYINKPAMARSIILQLKRVLAGTGCTSIFVSQISVGERGFGGPGVEHGVDGIIRLDLDEIDGELKRSLIVWKMRGTSHSMRRHPFDITDKGIIVYHDKILKRGRILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJT1</accession>
    <name>F0LJT1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468020.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01748"/>
    <dbReference type="EnsemblBacteria" id="ADT84723">
        <property type="protein sequence ID" value="ADT84723"/>
        <property type="gene ID" value="TERMP_01748"/>
    </dbReference>
    <dbReference type="GeneID" id="10042064"/>
    <dbReference type="KEGG" id="tba:TERMP_01748"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1747"/>
    <dbReference type="eggNOG" id="arCOG09530">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_671971_0_0_2"/>
    <dbReference type="OMA" id="GDANILW"/>
    <dbReference type="OrthoDB" id="131481at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="397" mass="45347" checksum="4F725AF1B85D28CE" modified="2011-05-03" version="1">MRNYKVAVITVFFIVMVFIPQVFALNVTCSPKVNVHEKVRCTVNGIGTAKIYLVAVDGIEIGHSRVWFFSETDDFIRESPSGVSLPIGIEFIPWSLLYRAVKNAFWTDSEYQWALYNRVNYFTFRFEFDNGTVEDVTIPIYIEGDAISEIKEILKAAIAFVSIISILVSIAYIWGRRKGEVPKNQDTSLPSRLSFIFLPFMLVEFYPAMAALFIYFSGSLSTLKGDANILWSIFVLLLWNFEVLSYRSAMLKARKKPITGIEWIPASIIRWSGLSFAVGLIGTVVLFAVSGKKSLNELFRRIAFPASLIWLIILTYTLSPNTILLLMLLVFSVWHVLLISGIESVIRAEEDVVLIENKHQRSPEVEELIQKFDRIIWEMKKDGFYERLSGGERNEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LJY4</accession>
    <name>F0LJY4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466819.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00544"/>
    <dbReference type="EnsemblBacteria" id="ADT83521">
        <property type="protein sequence ID" value="ADT83521"/>
        <property type="gene ID" value="TERMP_00544"/>
    </dbReference>
    <dbReference type="GeneID" id="26135918"/>
    <dbReference type="KEGG" id="tba:TERMP_00544"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.545"/>
    <dbReference type="eggNOG" id="arCOG01206">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_10_3_2"/>
    <dbReference type="OMA" id="TMNPFLK"/>
    <dbReference type="OrthoDB" id="108083at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="99" mass="11782" checksum="3BE1E9127302AF84" modified="2011-05-03" version="1">MKSLEEIEEILRRHKDELHKRFGVKKIAIFGSYARGEADELSDVDILVEFERPIGWEIVDLKEYLEEILGIRVDLITKNAALSRKRLWEQIRRDIVYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK13</accession>
    <name>F0LK13_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protease HtpX homolog</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">htpX</name>
        <name evidence="13" type="ordered locus">TERMP_00573</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466848.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00573"/>
    <dbReference type="EnsemblBacteria" id="ADT83550">
        <property type="protein sequence ID" value="ADT83550"/>
        <property type="gene ID" value="TERMP_00573"/>
    </dbReference>
    <dbReference type="GeneID" id="26135885"/>
    <dbReference type="KEGG" id="tba:TERMP_00573"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.574"/>
    <dbReference type="eggNOG" id="arCOG01331">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042266_3_0_2"/>
    <dbReference type="OMA" id="AVCCTEG"/>
    <dbReference type="OrthoDB" id="62484at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="12">
        <location>
            <begin position="68"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ADT83550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="292" mass="32540" checksum="D4931E9C49A33AEA" modified="2011-05-03" version="1">MGLGLWLRTGVLMAFLTGLLMALGYVLGSETGMIFAFIFALAMNFFSYWYSDKIVLTWYRARIVDEMEAPELHRIVEDLAREAGIPKPRVAIVPTDVPNAFATGRDPKHAVVAVTQGLLRILDRDELEGVLAHEISHIRNRDILIQTLAAVMAGAIIMIARWAGWMLWLGGFGGRDREGESGSILGAIVLIILAPIAAMMIQMAISRAREYLADESGAKISGKPWALARALEKIEYYVSRRPLRDGNPATAHMFIINPFRGVSLAELFSTHPPTQKRIERLRKIAEEMGMYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK25</accession>
    <name>F0LK25_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TERMP_01762</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468034.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01762"/>
    <dbReference type="EnsemblBacteria" id="ADT84737">
        <property type="protein sequence ID" value="ADT84737"/>
        <property type="gene ID" value="TERMP_01762"/>
    </dbReference>
    <dbReference type="GeneID" id="10042078"/>
    <dbReference type="KEGG" id="tba:TERMP_01762"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1761"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_2_0_2"/>
    <dbReference type="OMA" id="TIIMIHH"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="19"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="342" mass="39257" checksum="60026E827B20D294" modified="2011-05-03" version="1">MIESVNLTKFYPPPIKSLFDLKSLRDFLGKPREKIPALIDLSFKIKEGEIFGLLGPNGAGKTTFCKIANALVIPTRGNLYINGYDSVKEHDKVKGKIFTIFGGERDLFGLFQWRVSVEKNLKFIAELWGIPKVEAENRINYALELLNLKDKKNEWYQKLSAGMRQKVYLALPLIIQPEVLILDEPTVYLDVFTRREVWNAILELSKEFGTTIILTTHNLNEAEVLCNRVLIFNKKKIAEGKPKELIEKFQTLKIDRKLLVKIKGKIKIEDFNGIAEKINAYTQNGFTYLGIYIKRDYLKDILAILTNYDVVDIQNEPVTLEDVFTHICSFDSCVNSRAEEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK29</accession>
    <name>F0LK29_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01766"/>
    <dbReference type="EnsemblBacteria" id="ADT84741">
        <property type="protein sequence ID" value="ADT84741"/>
        <property type="gene ID" value="TERMP_01766"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01766"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1765"/>
    <dbReference type="eggNOG" id="arCOG02969">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032882_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M1" evidence="1">
        <location>
            <begin position="314"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="570" mass="66471" checksum="CDC0D9281C99304F" modified="2011-05-03" version="1">MKRKYLLGVLSVFIIFLLFFMRDDNNIQVTHVNILNLSISLVSDEELNNLANQSVIKGYSQVKIRIFENYTFNANKTIKVGNTGVVYVPVLYSPRIHFNDIFIENAELLNASILVSERGSILLLKLKIPKGTRAGIRFEYQGSIREQICARVGIIRTLFVKYESPDEIEMCPEMFLPEISNGFLETKIILELPQSWRTWTGIIVSNSGVLEPKAQLNGRLIFTSRGLFIPFLILGDFKMMRYNVNDVKVEIYFPKYLSLNVSSRYEDVVGDIIRTFSSWYMPYPYQNLTIIFSSNMMRMTGINKNSPILITANATPSLLAHEISHSWFGGYAEFGNIDESLATYSEMSYMIRFYNEHPEELENYARYNLTTIQKVLDFVEERVLKYNHDYPKPLSQVYRTWIPNSTIRNAIMYDKGAFVFRSLQFVLGNETFFKGLRELLRECHNKECNLTDVQNVFERVSGQNLDWFFKEWFYTAKVPDYDVRNLSLEEKGGKYLLTFEIIDKNNFTMPLEVEVKTPTKSFIKKVWINGTARVEFELDKKPTEIILDPNEWMVNENKKYNVDEIEITIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F0LK46</accession>
    <name>F0LK46_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468054.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01783"/>
    <dbReference type="EnsemblBacteria" id="ADT84758">
        <property type="protein sequence ID" value="ADT84758"/>
        <property type="gene ID" value="TERMP_01783"/>
    </dbReference>
    <dbReference type="GeneID" id="10042099"/>
    <dbReference type="KEGG" id="tba:TERMP_01783"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1782"/>
    <dbReference type="eggNOG" id="arCOG04083">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031404_2_1_2"/>
    <dbReference type="OMA" id="EEVQNSC"/>
    <dbReference type="OrthoDB" id="37383at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000180">
        <property type="entry name" value="Dipep_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00869">
        <property type="entry name" value="RENAL_DIPEPTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="311" mass="35368" checksum="C18AE2B7755781E6" modified="2011-05-03" version="1">MIFDAHSDLPTYVYDMRKEGKSRVLDREFERFFGGYIKARVMAVWTRQDKRAQALRYGLEVMNQLYKDVLESEKFAIVTNVEEMRSAIKNGRVALWLGLEGGEPIEDSLDLLEVFYELGLRVLTLTWSLRNAIGDGVFERTNGGLTNFGVEVLGKAEELGILVDLSHINERGFWDVLETTAFPVIASHSNAKALCDNKRNLTDEQIKAIAERDGVIGAVAIPSFVDKEKRTLDKYLDHIAYMADLAGYQHVGLGFDFVYYLKGWKGESVEGFEDESKIPALLEKLNERFSKKEVEAIAFKNFERVFERVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKC4</accession>
    <name>F0LKC4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT83582">
        <property type="protein sequence ID" value="ADT83582"/>
        <property type="gene ID" value="TERMP_00605"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_00605"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.606"/>
    <dbReference type="eggNOG" id="arCOG03811">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1792220_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="144" mass="16893" checksum="CCD5318122802B3B" modified="2011-05-03" version="1">MSLSVSVSPKALTSNEIFNITLRLKNVGAAPVRVIAPMRWISLSIEIYFENGTQIKYSGPRPSLLPPTDENLKVLQPGEEIVGIYEFSWGRRHEDGKIKDWYFPWKGRYRVVVTYNPNVRYSKITLPYWREKTLRAEDWFEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKG2</accession>
    <name>F0LKG2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466918.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00643"/>
    <dbReference type="EnsemblBacteria" id="ADT83620">
        <property type="protein sequence ID" value="ADT83620"/>
        <property type="gene ID" value="TERMP_00643"/>
    </dbReference>
    <dbReference type="GeneID" id="26136043"/>
    <dbReference type="KEGG" id="tba:TERMP_00643"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.645"/>
    <dbReference type="eggNOG" id="arCOG03169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061108_0_0_2"/>
    <dbReference type="OMA" id="REFEWRT"/>
    <dbReference type="OrthoDB" id="56889at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="358" mass="41515" checksum="C0472AD42B02BB02" modified="2011-05-03" version="1">MLFDPRPKMDRKELFDREEEIESLKKLADKPLVLLLGIRRIGKSSILRVALNELGNGIYIDARKLYFDSGGWITNDVLIRTFEKSLNSLKGEFKEKIIDALKYIRGVKLFGVDVRFKREVLLSEVLEALNDVGVVIGIDEAQYLRFYGSKGGKEFLALLAYSYDNLRNVHFILTGSEVGLLHDFIGIDNYESPLYGRVCEELTIVPFSRELSKEFLRQGFEEVSIQISEDDIEKAVEILDGIPGWLVDFGNEYIKIKSLEKALEGVMKRAEDFLKGELKELEKRSLRYVLILKAIARGYDRWELIKDYLERNSKRVPNSRLAELLRNLEKMSWITPELKDGRKKYKIIDPVVERVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKJ2</accession>
    <name>F0LKJ2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01851"/>
    <dbReference type="EnsemblBacteria" id="ADT84826">
        <property type="protein sequence ID" value="ADT84826"/>
        <property type="gene ID" value="TERMP_01851"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01851"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1850"/>
    <dbReference type="HOGENOM" id="CLU_2646109_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="76" mass="9021" checksum="1F58789FD628B003" modified="2011-05-03" version="1">MLGITSQMGYIVAYLVAIVSLYSLFLKMNYWSTGYLMGWIIGLYFLRGLFESWEWSIHMLIRILYLAKKLKRKIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKL3</accession>
    <name>F0LKL3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA polymerase II large subunit</fullName>
            <shortName evidence="13">Pol II</shortName>
            <ecNumber evidence="13">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Exodeoxyribonuclease large subunit</fullName>
            <ecNumber evidence="13">3.1.11.1</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">polC</name>
        <name evidence="16" type="ordered locus">TERMP_01872</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 13">Heterodimer of a large subunit and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the archaeal DNA polymerase II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="13"/>
    <dbReference type="EC" id="3.1.11.1" evidence="13"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468143.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01872"/>
    <dbReference type="EnsemblBacteria" id="ADT84847">
        <property type="protein sequence ID" value="ADT84847"/>
        <property type="gene ID" value="TERMP_01872"/>
    </dbReference>
    <dbReference type="GeneID" id="10042188"/>
    <dbReference type="KEGG" id="tba:TERMP_01872"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1871"/>
    <dbReference type="eggNOG" id="arCOG03145">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04447">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001154_0_0_2"/>
    <dbReference type="OMA" id="KRRNCDG"/>
    <dbReference type="OrthoDB" id="559at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008852">
        <property type="term" value="F:exodeoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000738">
        <property type="term" value="P:DNA catabolic process, exonucleolytic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00324">
        <property type="entry name" value="DNApol_II_L_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004475">
        <property type="entry name" value="PolC_DP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016033">
        <property type="entry name" value="PolC_DP2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42210">
        <property type="entry name" value="PTHR42210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03833">
        <property type="entry name" value="PolC_DP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00354">
        <property type="entry name" value="polC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="15">
        <location>
            <begin position="1172"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1711"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1711"/>
            <end position="1735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ADT84847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="1756" mass="200177" checksum="5A0A6D2D23E7A821" modified="2011-05-03" version="1">MSELYSEEMKAYFEMLQKEIDKAYEIAKKARAQGKDPVRDVEIPQATDMAGRVESLVGPKGVAERIRELAREYGKELAALKIVDEIIEGKFGKFDSKEKLAEQAVRTALAILTEGIVSAPIEGIAQVKIKKNPDGTEYLALYYAGPIRSSGGTAQALSVLVGDYVRKKLGLDKFKPTEKHIERMVEEVDLYHRAVTRLQYHPSADEVRLAMQNIPVEITGEATDDVEVSHRDVPGVETNQLRGGAILVLAEGVLQKAKKLVKYIDKMGIEGWGWLKEFVEAKEKGKTEEGTEEKAEKSKGEKAEVQTSVKVKKGFYYELYERFRANIAPNNKYTKEIIGGRPLFAEPSENGGFRLRYGRSRVSGFATWSINPAVMILVDEFLAVGTQMKTERPGKGCIVTPATTAEGPIVKLKDGSVIRVDDYYLALKIRDQVEEILYLGDAIIAFGDFVENNQTLLPANYVEEWWIQEFVKAVEDIYEVPLKPFAENDEEAVEEAADYLDLKPEFLAELLKDPLKIRPKVEEAIHLSKVLDIPLHPYYTLYWNTLKPEEVAELQSLLVNAEIEWDKYLGTKYAKKIVINLEVLGRKGKRYLELLGLPHRVEDKSVIIEYPWSAALLTPLANLEKKFEPKEFHTTIDIVNEVSEVKLRDRGISWIGARMGRPEKAKERKMKPPVHVLFPIGLAGGSSRDIYKAAQEGKLAEVEIAQFKCTNCSHIDIFPTCPVCGAEAKLLYRCPKCNYSSTEETICPKCGIEMRAYVKKTINPSHLVKQAMQNVRVNTLDKLKGVMGMTSAHKVPEPLEKGILRAKNDVYVFKDGTIRFDATDAPITHFKPREIGVSVEKLRELGYTHDFEGKPLVSEDQIVELKVQDVILSKEAGKYLVRVAKFIDDLLERFYGLPRFYNVEKMEDLIGHLVIGLAPHTSAGIIGRIIGFVDALVGYAHPYYHAAKRRNCFPGDTRILVQLNGMPQRITLRELYELFEEESYENMAYVRKKPKVDIKVYSFDEESGKVVLTDIEDVIKLPSTDHLIRFELELGRSFETTVDHPVLVYENGRFIKKRAFEVKEGDLILVPKIEFPEEDIDSIDLLEEFSKDEFKELRERIMVRGIAEWLMKIGAEVNPDYIRRNSIPLAVLLEVLKEKGLSIKDVPDCYIGFKPDHVKIRRFVPIGPLLRLIGYYLAEGYARESDSVYQISFSNGDEEVREDIKRALRKAFGDGFGIYERGEKITVGSRVIYLLFTRVLKIGKGAKDKRVPAFVFKLPKEKVRHLLQAYFEGDGTAIKSRPMIVVYSVNKPLLEDIDTLMIAKFNLYASWGVDKNANSRPGNIVQRYHEHRGRRVPVSTVYRLDYYGIQAKRFFEEIDFISERKNSVVNAWTNHKFQPYRRANEMGILVRVRRVEYVKPPEEWVYSLSVAKYHTVIVSDNITTSNCDGDEDAVMLLLDALLNFSRFYLPEKRGGKMDAPLVVTTRLDPREVDSEVHNMDIARYYPLEFYEATYELKSPKELVGVVERVEDRLGKPEMYEGLKFTHDTDDIALGPKLSKYKQLGDMEEKVRQQLALAEKIRAVNEHHVAETIINSHLIPDLRGNLRSFTRQEFRCVKCNTKYRRPPLSGKCPKCGGKIVLTVSKGAIEKYLPTAKLLVTNYDVLTYTRQRICLTEKDIKSLFANVFPETQRTLLALNTNDICDRMIAERTGKIVTKNGYLDEFHGNGRKVQKKVEAPKKVEKRELTKMQAHKPEKSEKHKPKKKKKVVSLDEFFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKP0</accession>
    <name>F0LKP0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretory protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01899"/>
    <dbReference type="EnsemblBacteria" id="ADT84874">
        <property type="protein sequence ID" value="ADT84874"/>
        <property type="gene ID" value="TERMP_01899"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_01899"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1898"/>
    <dbReference type="eggNOG" id="arCOG01819">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005379_2_2_2"/>
    <dbReference type="OMA" id="TGHDGCS"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="351"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="619" mass="69902" checksum="0C0FFEAC811EE645" modified="2011-05-03" version="1">MSWIEEILSKDAAPLENILGETDKKKEDKSRGAAFPFGSGGGLDSILSENSTKEEKTKSPFPFLKEEKSGVKLEDILGVPEKKPVEQTFPKEGRKETPLTLQDILGAPHKRGVIPPYVGEVKVLDAYGNVRILKVKGEPVPIYELRLPELSKDEEKLLKMVRDRAVVEIQIDPESIPDIEERRRIFLKAVKNMVREMAPTLSEGRIEILTELVVQNMIGYGRLDPLVRDDNLEEIMVIGTNKPVYVWHRRFNMCKTNIVFKDDREILNIIERIAREVGRRIDQQSPLLDARLPDGSRVNATIPPISLDGPTITIRKFKKDPLTIIDLIKYGTLNTEVAALLWIFVDGLGIKPANILVAGGTGSGKTTTLNSLAMFIPPSERVISIEDTAELQLPIEHWVRLETRPPNVEGKGEITMDDLVKNTLRMRPDRIIVGEVRGPEARTMFTAMNTGHDGCMGTIHSNSARETIVRLESPPMNVPRIMIPALDIIIMQIRYHSRKKGTIRRITEIAEVSGIEGESIQLNKLYKYDPAKDELVATGVPSRFMNILAQHTGLSLTELEIEKEKRKLVLEWMIERGIRGIEEVGHYIRQFYIDSEDLLKRIERESTSAELAKKVKSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKQ3</accession>
    <name>F0LKQ3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466930.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00655"/>
    <dbReference type="EnsemblBacteria" id="ADT83632">
        <property type="protein sequence ID" value="ADT83632"/>
        <property type="gene ID" value="TERMP_00655"/>
    </dbReference>
    <dbReference type="GeneID" id="26136055"/>
    <dbReference type="KEGG" id="tba:TERMP_00655"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.657"/>
    <dbReference type="eggNOG" id="arCOG04073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_5_6_2"/>
    <dbReference type="OMA" id="CISCRIC"/>
    <dbReference type="OrthoDB" id="123760at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="65" mass="7157" checksum="4F425D233B1B276E" modified="2011-05-03" version="1">MALPQVEILIDKEKCYLCGSCVAVCPKEAIIIENDEWKFFQEKCIGCKFCVLACPVGALSAKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKS3</accession>
    <name>F0LKS3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNase L inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_00675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466950.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00675"/>
    <dbReference type="EnsemblBacteria" id="ADT83652">
        <property type="protein sequence ID" value="ADT83652"/>
        <property type="gene ID" value="TERMP_00675"/>
    </dbReference>
    <dbReference type="GeneID" id="10040993"/>
    <dbReference type="KEGG" id="tba:TERMP_00675"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.676"/>
    <dbReference type="eggNOG" id="arCOG00187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017344_4_1_2"/>
    <dbReference type="OMA" id="ISYKPQY"/>
    <dbReference type="OrthoDB" id="13010at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="PTHR19248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="66"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="323"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="559"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="561"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="590" mass="66358" checksum="C8604C5208C08FDE" modified="2011-05-03" version="1">MRVAVIDYDKCNPDKCGHFLCERVCPVNRMGGEAIIIDEENYKPIIQEASCTGCGICVHKCPFNAITIVNLPEQLSEDCVHRYGVNGFVLYRLPVIKEGMVVGILGPNGIGKTTAVKILAGQLLPNLCGDNDSWDNVIKAFRGNELQNYFEKLKNKEIKPVVKPQYVDLIPKVVKGKVRDLLKRADERGLFDKVVKELELEGILDREIRQLSGGELQRVAIAAAVLRDAHFYFFDEPSSYLDIRQRLKAARLIRKLAAEGKSVLAVEHDLAVLDYLSDIIHVVYGKPGAYGIFSMPKGTRVGINIFLDGYLPDENVRFRPYEIRFTKLSERKSQTGEVLVEYPSLVKDYGSFRLEVEGGELYKGEVVGIVGPNGIGKTTFVKMLAGVEEPTEGKVEWELKVSYKPQYIKADYEGTVFELLSKIDASKLMSSFYKTELLNPLGIPELYDRSVNELSGGELQRVAVTACLLRDADLYLLDEPSAYLDVEQRLAVSRAIRHLMEKNEKTALVVEHDVLMIDYISDRLIVFEGEPGKFGKATKPMGMREGMNRFLASVGITFRRDPDTGRPRANKEGSVKDREQKERGEYYYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKX0</accession>
    <name>F0LKX0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013466997.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00722"/>
    <dbReference type="EnsemblBacteria" id="ADT83699">
        <property type="protein sequence ID" value="ADT83699"/>
        <property type="gene ID" value="TERMP_00722"/>
    </dbReference>
    <dbReference type="GeneID" id="10041040"/>
    <dbReference type="KEGG" id="tba:TERMP_00722"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.724"/>
    <dbReference type="eggNOG" id="arCOG07107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173775_0_0_2"/>
    <dbReference type="OMA" id="EWYRVDE"/>
    <dbReference type="OrthoDB" id="114220at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="120" mass="14148" checksum="2DD4925689C5B779" modified="2011-05-03" version="1">MEEWKERLKEEGYIEVGDFIIEVSVDSECPCKDDEVYPVIMIYDRKTESWYYVDEPFDPVNNFTEAWEEGIKVLEGYINGKEPRLKRTPKKFAPDDVIKRFAEALKTLENKTDSQSELNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F0LKZ4</accession>
    <name>F0LKZ4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TERMP_01926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468197.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01926"/>
    <dbReference type="EnsemblBacteria" id="ADT84901">
        <property type="protein sequence ID" value="ADT84901"/>
        <property type="gene ID" value="TERMP_01926"/>
    </dbReference>
    <dbReference type="GeneID" id="10042242"/>
    <dbReference type="KEGG" id="tba:TERMP_01926"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1925"/>
    <dbReference type="eggNOG" id="arCOG04064">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042134_1_0_2"/>
    <dbReference type="OMA" id="TIPLWYG"/>
    <dbReference type="OrthoDB" id="94875at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PTHR13325"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="185"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT84901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="375" mass="41526" checksum="67B10A7D8A7F8866" modified="2011-05-03" version="1">MNLWTVLIIILAFWGILYVLFGRKEEEEEGLAVDMFVIMWRTKKLLGFIDKIALKYRRFWKVYGTIGIIVGFGGMAFVFYMLIKSAFIAIKAKAQVAGVQLVIPGVTIPLWYGLIGLIVVMVVHELSHGVVARAEDLPLKSVGLVLFFVIPGAFVEPDEEELKKVPLVKRLRVYAAGSMANIVTALLALMLLNYALAPVLQPAGVEITQFDPKGPAINHLHEGDIIIGINGEQIKTIEDFLNFMNTTKPGQIIALEILRNGEKIIVKVPLGENPNNPEKGYLGVYPSQYVVSTIGYENIILPLAFALYWIYILNLGIGLMNLFPLIPLDGGRMLDETLKEYLPEKVAKPISFAFIGIGVLLLAINLIPAIRNLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLC1</accession>
    <name>F0LLC1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-dependent hydrolase-glyoxylase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467070.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00795"/>
    <dbReference type="EnsemblBacteria" id="ADT83772">
        <property type="protein sequence ID" value="ADT83772"/>
        <property type="gene ID" value="TERMP_00795"/>
    </dbReference>
    <dbReference type="GeneID" id="10041113"/>
    <dbReference type="KEGG" id="tba:TERMP_00795"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.797"/>
    <dbReference type="eggNOG" id="arCOG00498">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061754_0_0_2"/>
    <dbReference type="OMA" id="YAPWGEE"/>
    <dbReference type="OrthoDB" id="99711at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="15"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="290" mass="32601" checksum="199EDB4E00D69AE2" modified="2011-05-03" version="1">MGTKKLGENLYLYPGSPSTMIKIHEGKAVLVDVGHGSGRHKDLLREVRKLGSEVKALLATHGHADHISVATKIDKPLFIHRFEFSIAESPLNRELLTFGSKAPEGFLVFQFPHEVKVHAIFEWNDELFGLKTVKLSGHSPGMTGFVDEENCVVYSGDSFFGERIIQAVGVPYLVDVALFKDSIIQLHNYAIEGFLLIPSHGRPVKEEEAEKLLEFNLQRVEETEKKILELLKRPMSISELSYRLAKTFGAKITPQSLALNQVPIRAFIAELYNKGVIEAVIEKDLKWKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLC6</accession>
    <name>F0LLC6_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467075.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00800"/>
    <dbReference type="EnsemblBacteria" id="ADT83777">
        <property type="protein sequence ID" value="ADT83777"/>
        <property type="gene ID" value="TERMP_00800"/>
    </dbReference>
    <dbReference type="GeneID" id="10041118"/>
    <dbReference type="KEGG" id="tba:TERMP_00800"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.802"/>
    <dbReference type="eggNOG" id="arCOG04079">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134837_0_0_2"/>
    <dbReference type="OMA" id="KNVANFY"/>
    <dbReference type="OrthoDB" id="104082at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="194" mass="22732" checksum="433503516C2C2B40" modified="2011-05-03" version="1">MEFDEKEFEKEIKKKVLEAMEKAVDNEDKIKKLIEETIKDLTQQLKEAKSEEDLEIIEEKIEIMRDMLKTYEKSKGDEEDIQELKEVMGVLSESLPKIMDSIFGPIKELINEAYDPDKAEKFGKNVANFYKELVAAGMDPDKAFELTKEYMESMNFIKTLIAAFMKEKMGKIKNFEELKKFGKKKVTKDFEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLF2</accession>
    <name>F0LLF2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Preprotein translocase subunit SecG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Protein transport protein Sec61 subunit beta homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">secG</name>
        <name evidence="14" type="ordered locus">TERMP_02007</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468277.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02007"/>
    <dbReference type="EnsemblBacteria" id="ADT84981">
        <property type="protein sequence ID" value="ADT84981"/>
        <property type="gene ID" value="TERMP_02007"/>
    </dbReference>
    <dbReference type="GeneID" id="26137611"/>
    <dbReference type="KEGG" id="tba:TERMP_02007"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2004"/>
    <dbReference type="eggNOG" id="arCOG02957">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_208205_3_1_2"/>
    <dbReference type="OMA" id="MRFFDED"/>
    <dbReference type="OrthoDB" id="128075at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00751">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023531">
        <property type="entry name" value="Preprot_translocase_SecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ADT84981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="56" mass="6068" checksum="D9974AA25326A89A" modified="2011-05-03" version="1">MAKEKTTLPPTGAGLMRFFDEDTKAIKISPRGAIALVLIFIAIEILLHVFGTQLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLF8</accession>
    <name>F0LLF8_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Spt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spt4</name>
        <name evidence="4" type="ordered locus">TERMP_02013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of Spt4 and Spt5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal Spt4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468283.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02013"/>
    <dbReference type="EnsemblBacteria" id="ADT84987">
        <property type="protein sequence ID" value="ADT84987"/>
        <property type="gene ID" value="TERMP_02013"/>
    </dbReference>
    <dbReference type="GeneID" id="26137621"/>
    <dbReference type="KEGG" id="tba:TERMP_02013"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2010"/>
    <dbReference type="eggNOG" id="arCOG04077">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199467_0_0_2"/>
    <dbReference type="OMA" id="VCRECHR"/>
    <dbReference type="OrthoDB" id="119723at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00949">
        <property type="entry name" value="Spt4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007178">
        <property type="entry name" value="Spt4_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038589">
        <property type="entry name" value="Spt4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40704">
        <property type="entry name" value="PTHR40704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="SSF63393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Spt4" evidence="3">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADT84987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="61" mass="7081" checksum="BA8FFE9B6F8AF1EF" modified="2011-05-03" version="1">MKERACRHCHYITTEDRCPVCGSRDLSDEWFDLVIIMDVENSKIAQKLGVKVPGKYAIRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLM7</accession>
    <name>F0LLM7_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-(acyl-carrier protein) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467102.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00827"/>
    <dbReference type="EnsemblBacteria" id="ADT83804">
        <property type="protein sequence ID" value="ADT83804"/>
        <property type="gene ID" value="TERMP_00827"/>
    </dbReference>
    <dbReference type="GeneID" id="10041145"/>
    <dbReference type="KEGG" id="tba:TERMP_00827"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.829"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_2"/>
    <dbReference type="OMA" id="MFEVNVY"/>
    <dbReference type="OrthoDB" id="62124at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="240" mass="25892" checksum="A2D9063A5E0B6986" modified="2011-05-03" version="1">MKLAGKVALVTGASRGIGRAIAVALAQKGANVVINYVRNEEEAKRTEELCREYGVETLVIKADVSSREEVRKMVEAVIKKFGRIDILVNNAGILGNSINPLEITEEEWDKVISINLKGAFLVIQEVLRYMKKGKIVNITSIAGKDGGTVGAHYAASKGGLIALTFNLARHLAPNILVNAVAPGPVDTELIPPEIKEKLRKLSLTGEIAKPEDVAHAVIFLLENDHITGELIDVNGGRLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLN6</accession>
    <name>F0LLN6_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467111.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00836"/>
    <dbReference type="EnsemblBacteria" id="ADT83813">
        <property type="protein sequence ID" value="ADT83813"/>
        <property type="gene ID" value="TERMP_00836"/>
    </dbReference>
    <dbReference type="GeneID" id="26136285"/>
    <dbReference type="KEGG" id="tba:TERMP_00836"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.839"/>
    <dbReference type="eggNOG" id="arCOG05097">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1551886_0_0_2"/>
    <dbReference type="OMA" id="NAFHSMK"/>
    <dbReference type="OrthoDB" id="82284at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="103"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="174" mass="19590" checksum="A02FD7165D4FE02B" modified="2011-05-03" version="1">MSEVEKALQTFHSLKVKQVMPPLASMPIVTKDSPVVDVLKLLRTRHHVWVVNNRDDMKLEGVIRYINIVDVLLPPELQKARLGNISHLFKSILGGADRAEHVMERNVLTINEDASVLEALTKMKRYKVPLLAIIDENGKLVGEISLRILVNEFMRLMRIGGAQWSQSGSSSQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLP2</accession>
    <name>F0LLP2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467117.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00842"/>
    <dbReference type="EnsemblBacteria" id="ADT83819">
        <property type="protein sequence ID" value="ADT83819"/>
        <property type="gene ID" value="TERMP_00842"/>
    </dbReference>
    <dbReference type="GeneID" id="26136291"/>
    <dbReference type="KEGG" id="tba:TERMP_00842"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.845"/>
    <dbReference type="eggNOG" id="arCOG00017">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1954782_0_0_2"/>
    <dbReference type="OMA" id="GYVCSFH"/>
    <dbReference type="OrthoDB" id="125558at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="129" mass="15087" checksum="4C327B3709E718BA" modified="2011-05-03" version="1">MKINAFEVASKYVYPSLRRRLVEILYRDHKLTQTQVAELLHITQSAVSRYLRMNRGSFIDISNFQDIDNYLKELADKIIKEKLTEYQIHAELVEIALKMLGKGYLCPIHEKIDPELDPSKCRICIDLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F0LLX4</accession>
    <name>F0LLX4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_02099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013468369.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02099"/>
    <dbReference type="EnsemblBacteria" id="ADT85073">
        <property type="protein sequence ID" value="ADT85073"/>
        <property type="gene ID" value="TERMP_02099"/>
    </dbReference>
    <dbReference type="GeneID" id="10042414"/>
    <dbReference type="KEGG" id="tba:TERMP_02099"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2096"/>
    <dbReference type="eggNOG" id="arCOG01403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_1_2"/>
    <dbReference type="OMA" id="AIVFPSH"/>
    <dbReference type="OrthoDB" id="83551at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT85073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="382" mass="44146" checksum="717633148AAC7F94" modified="2011-05-03" version="1">MRILQFVPYFLPYPGGQERYVYNLSKYLVKMGHEVRVITSNFPKSKKFEEIDGITVERYNLITRPLRNPIVPKFLQVPKRFKEFDIVHIHNEHAFSSMVAAYAKKKEDFPLVLTNHGQLKFGNYIADTIEKTYMKTFGKKILELSDIIVVNSESDKEFLSTIAPKISNKTYILHNAIDPEVLTKLAKEADGNEWTMDADIKILYVGRLIRRKGVEWLIKAIKIIKNSTSKKIKCILVGEGEDRNYFEMLVREYNLSDSVVFAGRISDKKLAWLYENSDIFVLPSLSEGLPTTILEAMYFSLPVVATDIPGNRDHFKDVAILVPPKDEKALANSLLMLLENENLAKQLSKAGKKLVEEKYTWDRVAREYEKLYKNIIDQRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM32</accession>
    <name>F0LM32_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467177.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00903"/>
    <dbReference type="EnsemblBacteria" id="ADT83879">
        <property type="protein sequence ID" value="ADT83879"/>
        <property type="gene ID" value="TERMP_00903"/>
    </dbReference>
    <dbReference type="GeneID" id="26136348"/>
    <dbReference type="KEGG" id="tba:TERMP_00903"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.904"/>
    <dbReference type="eggNOG" id="arCOG01084">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142229_1_0_2"/>
    <dbReference type="OMA" id="MADVLWV"/>
    <dbReference type="OrthoDB" id="119163at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012359">
        <property type="entry name" value="MazG-related_YpjD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42692:SF1">
        <property type="entry name" value="PTHR42692:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029904">
        <property type="entry name" value="UCP029904_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="99" mass="11245" checksum="AA650727ED0DAE26" modified="2011-05-03" version="1">MNKLQREVDKLIRELGGYWAPFEMLAALVEELGELSDEMLKFENVKGNGKMENLKEEIGDVLFALLCIANYYGIDVENALLASISKYRNRDKLDGNDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM55</accession>
    <name>F0LM55_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Replication factor C large subunit</fullName>
            <shortName evidence="4">RFC large subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Clamp loader large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfcL</name>
        <name evidence="7" type="ordered locus">TERMP_00926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the activator 1 small subunits family. RfcL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467200.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00926"/>
    <dbReference type="EnsemblBacteria" id="ADT83902">
        <property type="protein sequence ID" value="ADT83902"/>
        <property type="gene ID" value="TERMP_00926"/>
    </dbReference>
    <dbReference type="GeneID" id="10041243"/>
    <dbReference type="KEGG" id="tba:TERMP_00926"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.927"/>
    <dbReference type="eggNOG" id="arCOG00470">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027255_1_1_2"/>
    <dbReference type="OMA" id="GGWTRYG"/>
    <dbReference type="OrthoDB" id="24257at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01508">
        <property type="entry name" value="RfcL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023935">
        <property type="entry name" value="Rep_factor-C_lsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="40"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADT83902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="503" mass="57779" checksum="E064083D0AE3CF90" modified="2011-05-03" version="1">MDIPWVEKYRPKRLREIVNQRQALEKVEAWIKQWVHGTPKKKALLLAGPPGSGKTTTVYALANEYKFEVIELNASDERTFEKIRRYLDAAYTMDIFGRRRKLIFLDEADNIEPSGAHEIAKLIDRARNPIIMAANKYWEVPAEIRNKAEVVEYKRLTQRDIMQALFRIIKAEGIFVPKEIVAEIAKRASGDLRAAINDLQTVVAGGIEDAREVLAYRDVEKTIFQALGLIFGSDNAKRAKMATWNLDMTPDELLLWVDENIPYIYYKPEDIAEAYNAISRADIYLGRAKRSGNYGLWKYAIDMMTAGVAVSGVKKKGFLKFYPPKTLRMLKDTKEERGIRDSIIKKIMKQMHMSKLEAIETMQIFKTIFENNLDVAAHIAVFLDLGDKEIEFLAGDKEKATKIKGKTLSIHRKLKKAGIEIKVEIEGEPSKEIEEEEIGEEPEEETAEAEGEEVSEEEKESKEIEKEIEEAEWEKEEKPKKEEKIDKAKKKGKQATLFDFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM62</accession>
    <name>F0LM62_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">DNA repair and recombination protein RadB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">radB</name>
        <name evidence="6" type="ordered locus">TERMP_00933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic RecA-like protein family. RadB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467207.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00933"/>
    <dbReference type="EnsemblBacteria" id="ADT83909">
        <property type="protein sequence ID" value="ADT83909"/>
        <property type="gene ID" value="TERMP_00933"/>
    </dbReference>
    <dbReference type="GeneID" id="10041250"/>
    <dbReference type="KEGG" id="tba:TERMP_00933"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.934"/>
    <dbReference type="eggNOG" id="arCOG00417">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_2_0_2"/>
    <dbReference type="OMA" id="GNTLEHW"/>
    <dbReference type="OrthoDB" id="93716at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00350">
        <property type="entry name" value="RadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011939">
        <property type="entry name" value="DNA_repair_and_recomb_RadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003336">
        <property type="entry name" value="RadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02237">
        <property type="entry name" value="recomb_radB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="5">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADT83909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="221" mass="25037" checksum="791703C6AC9746E4" modified="2011-05-03" version="1">MEKLTTGSKSLDELLGGGIERGVLTQIYGAFATGKTTLAMQIGMLNKGKVIYIDTEGGFSPERLKLMAEKRGIDPEETLQKFIIFEPHDFREQKRVISKLKTIVNNRFALIVVDSVTSHYRIEKDRQSLNVELGKQLQVLLWLARKYNIAAIVINQVYFDSNSGSLKPIAEHTLGYKCKDILRLEKLSKPGIRIAVLERHRFRPEGGIVYFKITDKGIEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LM65</accession>
    <name>F0LM65_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467210.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00936"/>
    <dbReference type="EnsemblBacteria" id="ADT83912">
        <property type="protein sequence ID" value="ADT83912"/>
        <property type="gene ID" value="TERMP_00936"/>
    </dbReference>
    <dbReference type="GeneID" id="10041253"/>
    <dbReference type="KEGG" id="tba:TERMP_00936"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.937"/>
    <dbReference type="eggNOG" id="arCOG02159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082100_0_0_2"/>
    <dbReference type="OMA" id="KSYIAVN"/>
    <dbReference type="OrthoDB" id="110032at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011672">
        <property type="entry name" value="DUF1614"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07758">
        <property type="entry name" value="DUF1614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="232" mass="24949" checksum="D479C7163F754B06" modified="2011-05-03" version="1">MKKFFFLPVSLPFLILLLLLIPILFLLFAGTITLAFQKLGLPLPVAYTLFWASLIGSFINIPIAETKTYAPILKVKEVSFFGIRYPVPYIDWGEQKMVIAINVGGALVPLSIVTYELLRFAIAGNMELIIRILVAILIATIFSNFFSKPVKGLGIAIPTFIPPLIAASLAFLLGGPNKPAIAYASGTMGVLIGADLLNWNRIKELGAPMVSIGGAGTFDGIFLAGIIAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMA3</accession>
    <name>F0LMA3_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_02152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT85126">
        <property type="protein sequence ID" value="ADT85126"/>
        <property type="gene ID" value="TERMP_02152"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02152"/>
    <dbReference type="HOGENOM" id="CLU_3283050_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT85126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="40" mass="4555" checksum="3602C9D6FDE1207E" modified="2011-05-03" version="1">MGIAPFLWNFTYKFFGKLSVDPKTNLINLHAKIFLVGTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMB0</accession>
    <name>F0LMB0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_02159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT85133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_02159"/>
    <dbReference type="EnsemblBacteria" id="ADT85133">
        <property type="protein sequence ID" value="ADT85133"/>
        <property type="gene ID" value="TERMP_02159"/>
    </dbReference>
    <dbReference type="KEGG" id="tba:TERMP_02159"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.2155"/>
    <dbReference type="eggNOG" id="arCOG02284">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_562170_0_0_2"/>
    <dbReference type="OMA" id="AVSIFWN"/>
    <dbReference type="OrthoDB" id="132760at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT85133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="485" mass="55473" checksum="4585AACE2E34B942" modified="2011-05-03" version="1">MRKKLLILCFFMLLFTHLAYSLAINNALIGNPTIFNITNASTQLLVVYFPSEDRFELLNLTSFPCKTNVCSNFTMIPIHCSSQGCLFYGCEGCNRPLPGRVYDHYGYLYPNGEFRELLSFRNDGAVSIFWNRDYYLVLHPFYCFSMWCNLEHFDSLLWLSTIKNGQAVVKKFGYLTGDFRNASLPLLAQKGYLYFVRNLKNGALGIFNQNFTKAVILIDAIPVLKVTSQFPLNNSQLIYDSERVYLLRNKTLYMVKPSKGDYHFPEDFRKVASFSDNLTLIGAYKGRLFLVSNNGTYIYDVENASLKMIVNSKAQMSEFHNGKALLFANSTLYDVSDNIVRVGKINLKTFNASEFHKLFYITLDCRKGHFEEGTNIFWSPKGWLIYNGYSLYFFNGTLRKVLDDASGIKWIGWDGEGFILAGNETVLEFDGQKIKNLTPKLREFLGATSPPSSSAQDSVSLILIVLLFTLMGAYLLRKRERKDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMG9</accession>
    <name>F0LMG9_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sarcosine oxidase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_00972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467246.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00972"/>
    <dbReference type="EnsemblBacteria" id="ADT83948">
        <property type="protein sequence ID" value="ADT83948"/>
        <property type="gene ID" value="TERMP_00972"/>
    </dbReference>
    <dbReference type="GeneID" id="10042553"/>
    <dbReference type="KEGG" id="tba:TERMP_00972"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.975"/>
    <dbReference type="eggNOG" id="arCOG00755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_4_1_2"/>
    <dbReference type="OMA" id="VPLDWEW"/>
    <dbReference type="OrthoDB" id="45129at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="7"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT83948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="389" mass="43405" checksum="577EDF02F9000A47" modified="2011-05-03" version="1">MKSRAEVVIIGGGVIGLSIAYHLGKLGVEDVVVLEKNYIGSGSTFRCASGIRAQFTDEANIKLQKYNIDRWRRLSDELEHDINFKQSGYLFLATSEEEVEVFKKNIKLQNKFGVPTRLISMDEAKEIVPPLNTEPFLAGAWNPEDGKASPFHVVYGFAKKAKEFGVEIYEYTPAVDILVEKSEIKGVKTEKGIIKTGIVINAANAWAPIINEMAGLKRDFIPIKPYKHQLVKTEPIAPGQIEPLTCPPAWNDSYVIQDGEDGGVICGTGLEKLTYLDDVQPTYDFMREVLKWATKIIPALKYVHVVRQWAGFYAKTPDSNPAIGRIQYVDEFYIAAGFSGHGFMMAPGVGEAIAELIVKGKSKVPLDWEWYDPHRFERGELRSAAFQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMH0</accession>
    <name>F0LMH0_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467247.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00973"/>
    <dbReference type="EnsemblBacteria" id="ADT83949">
        <property type="protein sequence ID" value="ADT83949"/>
        <property type="gene ID" value="TERMP_00973"/>
    </dbReference>
    <dbReference type="GeneID" id="10041290"/>
    <dbReference type="KEGG" id="tba:TERMP_00973"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.976"/>
    <dbReference type="eggNOG" id="arCOG05745">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172457_1_0_2"/>
    <dbReference type="OMA" id="CRCNDVT"/>
    <dbReference type="OrthoDB" id="115615at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer2_BFD" evidence="1">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="97" mass="10825" checksum="57459B5B9DE4803A" modified="2011-05-03" version="1">MRNKKNIIICRCNEVTQEEIEALIDQGVTDIEMIKRLLRIGMGPCQGRTCLPMVISILARKTGRRPNEIKLPATRIPVRPVPAGVLVGEMESDGNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMJ1</accession>
    <name>F0LMJ1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_00994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467268.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00994"/>
    <dbReference type="EnsemblBacteria" id="ADT83970">
        <property type="protein sequence ID" value="ADT83970"/>
        <property type="gene ID" value="TERMP_00994"/>
    </dbReference>
    <dbReference type="GeneID" id="10041311"/>
    <dbReference type="KEGG" id="tba:TERMP_00994"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.997"/>
    <dbReference type="HOGENOM" id="CLU_1109544_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT83970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="250" mass="28571" checksum="D44F8A82EDEA2263" modified="2011-05-03" version="1">MRKISSVLVIAMLLAVFSAGCMSEPNPKADLMELNSADSLTTGFSIKMFDPNSAGVYDMVDMWVSVESKNGKIVREAINFTVTMFTLKTHGYIYFENESTFRGYFAIDDPRNATLYTSEKEFMNKVGTFVTLTVPRDDQGWIINSDILKKLTFKKTGNNEYTAIMNVTNKEDLSKIMGTEITEEDMKKLESFQYKVEVVYRDGKLHTVRHYLIYKTPNVEKPLMYIITYSGVKKGFTKPGWVDEMMSSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMJ4</accession>
    <name>F0LMJ4_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA:acetoacetyl-CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_00997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT83973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467271.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_00997"/>
    <dbReference type="EnsemblBacteria" id="ADT83973">
        <property type="protein sequence ID" value="ADT83973"/>
        <property type="gene ID" value="TERMP_00997"/>
    </dbReference>
    <dbReference type="GeneID" id="10041314"/>
    <dbReference type="KEGG" id="tba:TERMP_00997"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1000"/>
    <dbReference type="eggNOG" id="arCOG01986">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026774_4_0_2"/>
    <dbReference type="OMA" id="GTDYNKR"/>
    <dbReference type="OrthoDB" id="10712at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT83973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="541" mass="59491" checksum="EBD642663B340969" modified="2011-05-03" version="1">MGRIVEINEAIDEIPDNSIIAVSGFNLLVAPEYLLLKLFEHYKETGHPKNIFLEVNPIPTAPNGVLDSIMKEIYNDPDQDFLSGILVTYPGWSPYLQKLIQENKIEGYTWPIGTASWFFREIARGFPGVITKVGIGTFLDGRQDAGYLNDLAKEKKRCKVQPIEINGDEYLLYTAPKPNVAFIRGTTSDEIGNITTEREGAFTDILNMAQAAKSLPNSGIVIAQVERIARFGSLHPQDVKVPAPLVDYVVIAPKEYHKQSANIQYDPRISGEIIPPAKPRVPEIPLNIRKVIARRILLEMVGIIKKLGRPILVNLGIGVPSEVAAIATEEGIQDYLFTTVESGPFGGVALGGPDFGASIGPFAIISMADQFANYEGGVIDAASLGFMQVDRHGNVNPSILPGRLPGPGGFPVISFGSPRIIFAGGFTAGKRDIRVENGQLKIIKDGSIIKFVNRVYKIVYNGKVGLERGQEVIYVTERAVFKLTKKGLVLEEVAPSVDVEKDILAKMEFEPKISPVIKEMEKRLFLAGKMRLEEEIKEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMN2</accession>
    <name>F0LMN2_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467309.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ADT84011">
        <property type="protein sequence ID" value="ADT84011"/>
        <property type="gene ID" value="TERMP_01035"/>
    </dbReference>
    <dbReference type="GeneID" id="10041352"/>
    <dbReference type="KEGG" id="tba:TERMP_01035"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1038"/>
    <dbReference type="eggNOG" id="arCOG05783">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1700352_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="154" mass="18424" checksum="790C26B9E041AE2A" modified="2011-05-03" version="1">MKITRIKPLYIPENQEKVKEVYYPVWIYVFSYVVKRRIFGDIKGNIIVLVDGINQKGYLADIFPEIEEIHVIDNKAKILEPQISDEKSEEIAKDRAEALLFRKYAYLKFTYQLTQKAFTYKLFWARKEENKYFLMDSITGEEIEVLPYEGHERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMV3</accession>
    <name>F0LMV3_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEGA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467380.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01106"/>
    <dbReference type="EnsemblBacteria" id="ADT84082">
        <property type="protein sequence ID" value="ADT84082"/>
        <property type="gene ID" value="TERMP_01106"/>
    </dbReference>
    <dbReference type="GeneID" id="10041423"/>
    <dbReference type="KEGG" id="tba:TERMP_01106"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1109"/>
    <dbReference type="eggNOG" id="arCOG03264">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_648338_0_0_2"/>
    <dbReference type="OrthoDB" id="46542at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="2">
        <location>
            <begin position="219"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADT84082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="423" mass="47291" checksum="9B525476FE51F38D" modified="2011-05-03" version="1">MKKRYALAFFLMIVIFANYASAVYVEMWSYDLNSGLRWPEREVSKIVLLGNYALPVACRLFEFDKVWVFNESGLVAEFQLQNPIRVRSQEECNSISFAYRNGTLSVLYGNETWANFTITLNVKNVNPPNLKVSYGGSGIVELPLGQPSGYVEITTEHGDTQRITLPYPVGAVALIKNGIFIGTKGYEYFNRAGTWGEMGPFYAYVGIVYFFKDVPGGYLSIKSNVKAKVFVDGKDKGWAPAVVPLPAGEHDVRVVSFGVPKEYRVEIEENKTTALNVTYQTGYLEVFLPVHAWVKVDGIVIGDSSQRIELPAGNHTVTIFCIGCPDEKYSGIKANFQVAVKAGKTTRLEIAKEMLGIGTPESKNTRKLSYITSIIQIESDNPTMTVTLTQTQPQENRMYSKLITLFAVVILVELGIYLLLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMW2</accession>
    <name>F0LMW2_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
            <shortName evidence="6">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serS</name>
        <name evidence="9" type="ordered locus">TERMP_01115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="6"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467389.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01115"/>
    <dbReference type="EnsemblBacteria" id="ADT84091">
        <property type="protein sequence ID" value="ADT84091"/>
        <property type="gene ID" value="TERMP_01115"/>
    </dbReference>
    <dbReference type="GeneID" id="10041432"/>
    <dbReference type="KEGG" id="tba:TERMP_01115"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1118"/>
    <dbReference type="eggNOG" id="arCOG00403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_2"/>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="OrthoDB" id="16385at2157"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
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    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="199"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="6">
        <location>
            <begin position="252"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="370"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="406"/>
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        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
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            <dbReference type="ARBA" id="ARBA00001032"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ADT84091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="455" mass="53218" checksum="CDF2BA3C2354A8A6" modified="2011-05-03" version="1">MLDIKLIRENPDIVKGDLIKRGELEKLKWIDEILELDKKWRENLRKINQLRRERNRIAVEIGKRKKAGESVDDLLTKSKEIVKQIEILEKENEEIRKKIDFYLWRLPNITHESVPIGKDDTENVPIKFWGKARVWKGHLESFLEQSQGKMEYEVLEWKPKLHVDLLEILRGADFERAAKVSGSRFYYLLNEIVILDLALIRFALDRLIEKGFTPVIPPYMVRRYVEEGVTTFDDFENVIYKVEGEDLYLIPTAEHPLAGMHANEIIDGKDLPLLYVGVSPCFRKEAGTAGKDTKGIFRVHQFHKVEQFVYSRPEESWEWHEKLLQNAEELFQELEIPYRVVNICTGDLGYVAAKKYDIEAWMPGQGKFREVVSCSNCTDWQARRLNIRFRDKTHEKPKFVHTLNSTAIATSRAIVAILENFQEEDGTVRIPKALWKYTGFKEIVPADKKEKCCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMX1</accession>
    <name>F0LMX1_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Archaeal ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TERMP_01124</name>
    </gene>
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        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
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            <taxon>Euryarchaeota</taxon>
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            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 11836 / MP</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
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        <property type="entry name" value="DUF234_ATPase_C"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
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            <begin position="5"/>
            <end position="200"/>
        </location>
    </feature>
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            <end position="402"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
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    </evidence>
    <sequence length="459" mass="54255" checksum="F1A54B1EEB9D2890" modified="2011-05-03" version="1">MYEQFVNRENELEALRKAYISKRKELIIVYGRRRVGKTALVQKSVKSLNHIYFFAEETLEEENLLMFRKLTAEVLGNPIIAKAELSWEELFELLDGSNVIVIIDEFPNLIKSNRAIISKFQKIWDSSKNLKLVLTGSSISIMESQVLGYKSPLYGRRTLSIKLEPLKFFHLREFFPEKSWEELVRIYGITDGIPAYIKEVQFRLSAGEKLEGVFQPNKPLFDEAEFLLRTELREPARYFAILKAIAFGKTKFGDIVSFTGLPSSTVSQYLSNLQTLHIVEEKHPVGEPERRRNARYYLSDLYFNFWFRFVYPNRSQLLEFGYIENFEEEYNQYLGFVFEKVVEQFLRELNRREKLPFKFTKIGKWWHKNEEIDLVALNEREKKALFVEVKWKDLKDREARGVLKDLERKAELVGLDGWTKAYGLVAKSLEGKEKLRSKGWLVWDLEDFERLIEKKDVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMX4</accession>
    <name>F0LMX4_THEBM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxylate reductase</fullName>
            <ecNumber evidence="1">1.1.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gyaR</name>
        <name evidence="5" type="ordered locus">TERMP_01127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 11836 / MP</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycolate + NAD(+) = glyoxylate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.26" evidence="1"/>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467401.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01127"/>
    <dbReference type="EnsemblBacteria" id="ADT84103">
        <property type="protein sequence ID" value="ADT84103"/>
        <property type="gene ID" value="TERMP_01127"/>
    </dbReference>
    <dbReference type="GeneID" id="10041444"/>
    <dbReference type="KEGG" id="tba:TERMP_01127"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1130"/>
    <dbReference type="eggNOG" id="arCOG01755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_2"/>
    <dbReference type="OMA" id="KMKPNCI"/>
    <dbReference type="OrthoDB" id="36410at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047964">
        <property type="term" value="F:glyoxylate reductase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00776">
        <property type="entry name" value="GyaR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023519">
        <property type="entry name" value="Glyoxylate_reductase_GyaR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="6"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="111"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="240"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="289"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ADT84103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="336" mass="38424" checksum="D4A6949891486097" modified="2011-05-03" version="1">MRKPKVFITRQIPETAINVIREYYEVEVWRDEKEPPREVLLEKVRDVDALVTLLSDKIDREILDNAPRLRIIAQYAVGYDNIDIEEATRRGIYVTNTPDVLTEATADFAWALLLATARQLVDADKFVRSGEWKRKGVAWHPLMYLGYDVYGKTIGIIGFGRIGQAIARRARGFNMKILYYSRTRKPEKEEELGAEFKPLNELLRESDFVVLAVPLTKETYYMINEKRLKLMKPMAILINIARGKVVDTKALIKALEEGWIAGAGLDVFEEEPYYNKELFKLKNVTLAPHIGSATYGARYAMAELVARNLIAFAKGEVPPTLVNREVLNVRKPGFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F0LMX5</accession>
    <name>F0LMX5_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TERMP_01128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467402.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01128"/>
    <dbReference type="EnsemblBacteria" id="ADT84104">
        <property type="protein sequence ID" value="ADT84104"/>
        <property type="gene ID" value="TERMP_01128"/>
    </dbReference>
    <dbReference type="GeneID" id="10041445"/>
    <dbReference type="KEGG" id="tba:TERMP_01128"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1131"/>
    <dbReference type="eggNOG" id="arCOG04291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1192595_0_0_2"/>
    <dbReference type="OMA" id="YVMFNNV"/>
    <dbReference type="OrthoDB" id="61105at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADT84104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="236" mass="28115" checksum="8828B593968D5A3B" modified="2011-05-03" version="1">MIFVGTCGFCEARKRYFQNFKTVEIQQTFYRILKEKTLKKWQSEAPEDFIFSIKAFQGITHPANSPTWKRSNVKPSRDVGFLKPTNEVFKYWEITLNEARILNASFILIQLPKSFKETEENFANAEGFFSKISRDIEIAVELRGWSEKGIKKFVREFDVIDVTDPLARKPLHKGNINYYRLHGAYENGRIIYKHKYTDEELEKIAERVKEWNKKESYIYFNNVYMCDDAKRFKRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-03" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F0LN31</accession>
    <name>F0LN31_THEBM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TERMP_01184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermococcus barophilus (strain DSM 11836 / MP)</name>
        <dbReference type="NCBI Taxonomy" id="391623"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Thermococci</taxon>
            <taxon>Thermococcales</taxon>
            <taxon>Thermococcaceae</taxon>
            <taxon>Thermococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="1481" last="1482">
            <title>Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.</title>
            <authorList>
                <person name="Vannier P."/>
                <person name="Marteinsson V.T."/>
                <person name="Fridjonsson O.H."/>
                <person name="Oger P."/>
                <person name="Jebbar M."/>
            </authorList>
            <dbReference type="PubMed" id="21217005"/>
            <dbReference type="DOI" id="10.1128/JB.01490-10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 11836 / MP</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002372">
        <property type="protein sequence ID" value="ADT84160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013467458.1">
        <property type="nucleotide sequence ID" value="NC_014804.1"/>
    </dbReference>
    <dbReference type="STRING" id="391623.TERMP_01184"/>
    <dbReference type="EnsemblBacteria" id="ADT84160">
        <property type="protein sequence ID" value="ADT84160"/>
        <property type="gene ID" value="TERMP_01184"/>
    </dbReference>
    <dbReference type="GeneID" id="10041501"/>
    <dbReference type="KEGG" id="tba:TERMP_01184"/>
    <dbReference type="PATRIC" id="fig|391623.17.peg.1187"/>
    <dbReference type="eggNOG" id="arCOG10611">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2115597_0_0_2"/>
    <dbReference type="OMA" id="IGAFFDW"/>
    <dbReference type="OrthoDB" id="109840at2157"/>
    <dbReference type="Proteomes" id="UP000007478">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADT84160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007478"/>
        </source>
    </evidence>
    <sequence length="102" mass="11701" checksum="FC277A28D41CE10A" modified="2011-05-03" version="1">MNRQKLTMLCVALAGLIFIPSVFFNKPSFALIGAFFDWLPLPTGWMKAEKEINRTFLKLHVAVTLIAYVVFVAWLIKRAATVGFTFLEIWWLAVIFGVLMNY</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>